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Reference: Figtree et al. (2021). Mortality in STEMI patients without standard modifiable risk factors: a sex-disaggregated analysis of SWEDEHEART registry data. Lancet (Online First, March 09)
https://doi.org/10.1016/S0140-6736(21)00272-5
EMB/MED/SFF/CVS/21/03/EM/04 SMuRFs, standard modifiable cardiovascular risk factors
STEMI withoutSMuRFs
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STEMI commonly occurs in the absence of four common CV risk factors:
Hypertension
Hypercholesterolemia
Current Smoking
DiabetesSuch patients have worse
outcomes as compared to those who have at least
one SMuRF
Patients without SMuRFs lack modifiable targets for therapy
0
2
4
6
8
10
12
14
16
18
20
MEN WOMEN
9.3
17.6
6.1
11.1
N = 7064N = 34600
N = 18220
N = 2164
Patients without SMuRFs Patients with at least one SMuRF
All
caus
e m
ort
alit
y (%
of
pat
ient
s)
The increased mortality rates can be attenuated after use of guideline-indicated treatments