Compilation of small ribosomal subunit RNA sequences
Erik Huysmans and Rupert De Wachter*
Departement Biochemie, Universiteit Antwerpen (UIA), Universiteitsplein 1, B-2610 Antwerpen,Belgium
INTRODUCTION
In the present compilation of small ribosomal subunit RNA sequences
(also named 16 S-like ribosomal RNA; further abbreviated srRNA) an attempt is
made to list all such sequences published up to and including 1985. The se-
quences are presented in the form of an alignment based on primary structure
homology and containing information on the presumed secondary structure. The
57 sequences included are listed in Table 1 and belong to 14 eukaryotes, 9 ar-
chaebacteria, 13 eubacteria, 4 plastids and 16 mitochondria. Only complete or
virtually complete sequences were included. Since papers on srRNA structure
are appearing at an increasingly rapid pace, some recent papers may have es-
caped our attention or reached us too late to meet the publication deadline,
for which we apologize to their authors.
CONVENTIONS AND SYMBOLS USED IN THE SEQUENCE ALIGNMENT
The 57 sequences appear in the alignment in the same order, and bearing
the same number, as in Table 1. In addition to its number, each sequence is
identified by the initials of the species name. The numbering at the top and
the bottom applies to alignment positions, not to the nucleotides of an indi-
vidual sequence. The sequences are divided in 5 blocks, comprising srRNAs
from eukaryotes, archaebacteria, eubacteria, plastids and mitochondria.
All the sequences are presented as RNA chains, i.e. using the symbols A,
C, G and U, although most of them have been analyzed on the DNA level. A set
of symbols for incompletely specified residues, listed in Table 2, has been
recommended by the IUB nomenclature comittee (63,64). These symbols are onlyused to denote sequence heterogeneity detected at certain positions of srRNAs
analyzed by RNA sequencing, in other words they denote heterogeneity due to
gene polymorphism. In contrast, nucleotides incompletely identified duringsequencing of a cloned gene are denoted by the symbol X.
*00)000.._00N0)401 C0-*00 N0140)0t.400N040)0000. NN N IO 0 0 01)4-444444440)0Ja)0)0)0)0D))O0)QQC :
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Footnotes to Table 1a) This number precedes and follows the sequence on each alignment page and is
also the reference number of the paper from which the sequence was taken.b) This column contains the following data, if specified by the authors.
- Strain name for laboratory animals, (cultivated) variety for plants, cul-ture collection and strain number in the case of microorganisms.
- Tissue from which the DNA used for clone construction, or the RNA usedfor sequencing, was extracted in the case of differentiated organisms.
- Ribosomal RNA operon to which belongs the cloned srRNA gene in the caseof bacteria.
c) The taxonomic position is described according to the following references(68) for metazoa and protozoa, (69) for Ascomycota, (70) for algae and phy-toflagellates, (71) for higher plants, (72) and (73) for archaebacteria,(74) for eubacteria. Taxon disignations corresponding to an establishedtaxonomic level are followed by the abbreviation Ph. (phylum), Sph. (sub-phylum), Cl. (classis), or 0. (ordo).
d) The chain length is not mentioned in case the location of the srRNA terminion the sequenced DNA is uncertain.
e) Two different sequences have been reported for rat srRNA, both are listed.f) The primary structure was derived by RNA sequencing.g) Partial data on modified nucleosides are mentioned in the paper reporting
this sequence or other papers cited therein.h) A sequence missing one nucleotide (A*05) was previously reported in (58),
where complete data on nucleoside modification can be found.i) This paper contains a sequence corrected with respect to the original re-
port (59).j) The termini were allocated by comparison with a sequence from a related
species.k) A slightly different structure was previously determined by RNA sequencing
(60) and a sequence missing one nucleotide (Ug,) of the rrnB srRNA (61)was corrected in (27). Complete data on nucleoside modification appear in(60) and (61).
1) Approximately 15 nucleotides adjacent to the 5'-terminus are missing be-cause they were not comprised in the cloned sequence.
m) A somewhat different sequence was reported previously (62) without locali-zation of the termini.
n) The location of the termini is uncertain.o) The location of the termini is not according to the original paper (53) but
according to (54).
Table 2. Symbols denotinf sequence heterogeneity
Symbol Nucleotides Dresent Symbol Nucleotides Dresent
R A and G H A, U, and CY U and C B G, U, and CW A and U V A, G, and CS G and C D A, G, and UM A and C N A, G, U, and CK G and U
These symbols are used only to denote positional heterogeneity found by RNAsequencing (see text).
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Posttransscriptional nucleoside modifications are not mentioned in the
alignment, mainly because there exist no conventional one-letter abbreviations
for all the modified residues encountered in srRNA. Moreover, data on modi-
fied residues exist only for a few sequences. References to papers containing
such data are mentioned in Table 1.
The alignment of sequences for optimal homology has been obtained without
the aid of a computer program. It is based on the existence of conserved se-
quence blocks, and on homology in secondary structure (see below). Certain
sections of several sitochondrial srRNA sequences are printed in more con-
densed format, without a space between the characters. These are sections
where it is especially difficult to discern homology with srRNAs from other
species. It has been attempted, however, to optimize homology between cor-
responding condensed-format sections in species that are adjacent in the
alignment. There are other areas where sequence alignment is rather arbitrary,
often corresponding to those loops in the secondary structure models (see be-
low) for which loop length is variable from one species to the other. In
general, sequence alignment is much more questionable in the variable areas
than in the conserved areas of the secondary structure models. The areas of
dubious homology may shrink in the future by the application of alignment
algorithms or/and availability of additional sequences for comparison. For
the moment being, their existence should be taken into account in applications
of the data for studies in molecular evolution.
SECONDARY STRUCTURE
The boxes superimposed on the sequence alignment enclose segments pre-
sumedly involved in base pairing. The boxes enclosing the complementary se-
quences forming helix 1 are numbered 1 and 1', and so on. Internal loops and
bulges are indicated by nested boxes. Bases that may belong to pairs other
than G.C, A-U or G*U (non-standard-, non-canonical or odd base pairs) are put
in parentheses. Two sets of helix numbers appear in the alignment. One set
Is listed under the uppermost block consisting of eukaryotic srRNA sequences,
and applies to these structures. A second set of numbers is listed between
the eubacterial and the plastidial srRNA sequence blocks and applies to all
prokaryotic structures.
In the case of prokaryotic srRNAs, the model proposed by Noller, Woese
and collaborators (65,66) is followed. Bacterial and chloroplast srRNAs fit
well into this model, but such variability is observed in the structure of
mitochondrial srRNAs, which show deletions as well as insertions of secondary
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structure areas with respect to the bacterial model. Insertions prevail in
plant mitochondrial srRNAs (56) which have chain lengths approaching 2000 nu-
cleotides, while deletions prevail in animal mitochondrial srRNAs (46,47)
which have chain lengths of less than 1000 nucleotides. Among the srRNAs of
fungal and protist mitochondria, both insertions and deletions account for
structural variability with respect to the bacterial secondary structure
model. Eukaryotic (cytoplasmic) srRNAs are fitted into a variant model (7)
related to those proposed for Xenopus laevis (6) and Dictyostelium discoideum
(67) srRNAs. This model was shown to be applicable to srRNAs from 6 eukaryotes
in a previous compilation (7) of srRNA sequences, and proved to remain appli-
cable to all of the 14 eukaryotic structures presently published.
The prokaryotic and the eukaryotic srRNA models applied to the sequence
alignment are illustrated in Fig. 1 and 2. The two models are for a large
part homologous, but there are two kinds of differences, both localized in
some of the areas of variable primary and secondary structure that are labeled
Vl to V8. The first kind of difference is found in areas V2 and V4, where
eukaryotic srRNAs possess extra helices with respect to prokaryotic srRNAs.
The second kind of differences resides in area V5, which shows variability of
a different type. Here, it is not the absence or presence of a helix that
makes the difference, but the topology in which the helices are folded, in
other words the order of occurrence of complementary sequences when the chain
is scanned from 5'- to 3'-end. It should be noted that eukaryotic srRNA se-
quences can also be fitted into a model having the prokaryotic topology in
area V5, although at the cost of forming a less stable structure. A recent
review on srRNA structure (66) lists such models for five eukaryotic srRNAs,
but base pairing in the helix corresponding to P18 (our numbering system) is
questionable. Conversely, certain prokaryotic srRNAs can be fitted into a
eukaryotic-type model, which again does not seem to fit them as nicely as the
prokaryotic model, but we have not investigated this possibility for all
presently known prokaryotic srRNAs. The possibility that area V5 may undergo
a structural switch, or may be a case of evolutionary divergence in secondary
structure, has been discussed (7).
The helix numbering system (7) adopted in the alignment and in Figures 1
and 2 attributes a separate number to each helical area, which may consist of
an uninterrupted helix, or a set of helix segments connected by bulges or in-
terior loops. Helices (or helical areas) bear a different number only when
separated by a multibranched loop (e.g. helices 7 and 8), or when separated bya single-stranded segment which does not form a loop (e.g. helices 23 and 39).
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Numbers are attributed in the order of occurrence of the 5'-proximal strand of
the helix in the sequence. Helices that are common to the prokaryotic and
eukaryotic models bear a single number from 1 to 40. In areas where the two
models differ in pairing scheme, helices are numbered in the format Pa or Pa-b
(prokaryotic srRNAs) and Ea or Ea-b (eukaryotic srRNAs) where a is the number
of the preceding common helix and b is a serial number. As an example, E9-1
and E9-2 are eukaryote-specific helices encountered after common helix 9 when
scanning sequences from the 5'-end. The common helices are not universal in
the sense that some are missing in certain mitochondrial srRNAs, but they are
present in all hitherto examined eukaryotic, archaebacterial, eubacterial and
plastidial srRNAs. Future refinements of the secondary structure models may
bring to light additional common helices and necessitate a revision of the
numbering system.
In sorting out the base pairing schemes superimposed on the sequence
alignment, we were often aided by the availability of secondary structure
models proposed in the paper reporting the srRNA sequence or in (66). How-
ever, we did not necessarily adopt such models entirely. There are two main
differences between the secondary structures proposed here and a set of 20
srRNA secondary structure models published by Gutell et al. (66). In area V5,
we assume a different topology in eukaryotes and prokaryotes whereas they
assume the same folding. Conversely, in area V3 we assume the presence of the
same topology in eukaryotes and prokaryotes while they assume a different one.
In the case of trypanosome mitochondrial srRNAs (52-54), it is especially dif-
ficult to propose a meaningful alignment and secondary structure model. Not
only are the sequences exceptionally short, but they are also very A*U rich
and hence very monotonous. Only a limited set of segments of these sequences
is aligned with other srRNA sequences according to the proposal of Sloof et
al. (52), the remainder being printed in condensed format.
AVAILABILITY AND ACCURACY OF THE DATA
The sequences presented here were entered in our database and checked to
the best of our ability for errors. They were not checked against a central
data base such as EMBL, one reason being that many of the sequences are pub-
lished very recently and there is some delay before they appear in central
data bases. We intend to carry out such checks in the future and to updatethe compilation regularly. Authors are invited to inform us about errors and
omissions of published sequences, and to send reprints of their newly pub-lished sequences.
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34
V7
13
40I I
10 nucleotides
V8
39
V2
Fig. 1. Secondary structure model applied to prokaryotic srRNAs.Helices, defined as described in the text, are numbered in the orderof occurrence from the 5'- to the 3'-terminus, symbolized respecti-vely by a dot and an arrowhead. Forty helices present in eukaryotic*as well as prokaryotic srRNAs (with the exception of certain mito-chondrial srRNAs) are hitherto distinguished. Additional helicesspecific for prokaryotic srRNAs bear a number preceded by P. A prob-able interaction between the sequence preceding helix 1 and a segmentof the multibranched loop separating helices 1 and 2 is not numbered.Bold lines are used for areas relatively conserved in primary andsecondary structure. Thin lines are used for variable areas, numberedVI to V8.
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32 30 33
20
34
V721
V4 27
25
E19-
36
16
15
11
10 nucleotides
V839
E9-2
Fig. 2. Secondary structure model applied to eukaryotic srRNAs.Conventions and numbering system are as in Fig. 1, except that heli-ces specific for eukaryotic srRNAs bear a number preceded by E.
The srRNA sequence compilation is available to interested scientists in
computer-readable form, either on magnetic tape or on floppy disks. An up-
dated version of a file containing 5 S rRNA sequences, in the format used in
previous publications (75) is also available. It is our hope that these com-
pilations will be an aid for studies on rRNA structure and molecular evolu-
tion.
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I3? 3? ~~~~~~~~~~~~~? 3? IA? I'~~~~~~~~~~~~~~?INS.------------------------U A C C US66UU 6A U C CUS6C C A 6U A 6 IA UA U6CU-US6U CU CA AA 6A U UA2H....------- ------U A CC U6G6U U 6A U CCUSCC ASUA 6 -(C)A UA U6CU -US6U C U CA AAG6A U UA3 R.n------------------------ JA CC U6SU U6A U C CU 6C C ASU A IA UAU6C U -U 6U C UC AAAS6A UU AANRn.------------------------ UA CC US66UU 6A U CC UG6C C A 6UA6-CA UA U 6C U -US6UC UCA A A 6AUU ASUe.c------------------------I A C CU 6 6UUS6AU C CUS6C C A6U A 6-(C)A UA U6CU -U6U CU C AAA 6A UU A6X.1.------------------------IJ A C CUS66U U A UC CUS6C CA 6U A6-(C)A UA U6C U -U U C UCA AAS6A UU A7 A.s.------------------------IJ)A C CU6 6U U 6A UC CU 6C C A U A 6(CA UAU 6C U - U6U C UC AAA 6A UU AN S.c -------------U A UC U6 6U U 6A U C CUSCC A 6UA 6U A U AU 6C U -U 6U U CA AA GA U UA9Ud.------------------------U AA C U6 6UU 6A UC CU 6C CA 6U A 6UJC A UAUS6C U -US6U C U CA AAS6A UU A0OOn.------------------------ A A UC U 6U UG6A U CC U 6C CA 6UAS6UICIA U AU 6C U -UG6UC UC AAA 6A CU A11 S.p -------------A A UC U6 6U U 6AU C CUSC CA6U A 6U CjA UAU 6C U -U6 UC U CA AA 6A C UA12T.t.------------------------ AA C C U66U US6AU CC U 6C CA 6UMUA-I)A UAUS6C U -U6UC U UA AA UA U UA131n.s------------------------UA CC U 6SU U 6A UC C U 6CC A GA6U[EA UA U 6C U -U 6UCUC AA A 6A U UA14 ZLa.------------------------IJ A CC US66U U6AU CC U 6CCA6U AS6UICA UA U6C U -UG6UC UCA AAS6 A UVUA15 6... ------------- UA C UU66U U 6AUCC U 6C C AS6UA 6UI.A UA U6C U -U UC UCA AA 6A UU A
23317NH.h.------------------------ AU UIC CS66UIUG6A U CC US6C C 6AS66C C AU- US6C U A UC 6S6ASU CCS6A UU UIBNH.v------------------------ AU UIC CS66UIU 6SAU C C US6C CS6 GA 66U C A U - US6 CU A U US6666SUC C 6 A U U U19Hi-----N-------- AU UIC CS66UIU6A U C C US6C C6S6AS66C U AU -US6C U AUC6666U CCS6A UU C
23S.s.------------------------AVUUC C 66UU 6AU CCU6C C6S6A C C C 6AC - CS6C U A U CS6S66S6U AS6 AU A
26P.t.------------------CSA A C UAU AS6AS6U U US6A U CCUSC U C AS6AU US6A A CS6CUS66CS66CAU6C U- -U U27 E.e, ---------- A AA U US6A ASAS6UU US6AU C AU66C UC AS6AU US6AA CS6C US66CS6SC AS66C C- -U A28 P.v.------------------- UAAU US6A AS6AS UUUSA UC AUS66C U C AS6AU US6A ACS6C US66CSG6C AS66C C- -U A
32N.s-------------,-- UAA A AU - 6 A SAS6U U US6AUCCU66C UC AS66AU0A AA CS6C US66C 66CA U 6CC - -U A33 It.? .---------UUACA ACS6A AS6AS6U UUS6A U CCU66C U CA66A U 6A A CS6CUAS6 CU AC AS66CUC - - UIA34 F.h----- . IJU A CA A US66AS6A6U UUS6AUC C US66C UC A6S6A US6A A CS6C UAS6C66CA66C C - - UIA35 D.d.------------------US6A A C US66A 6AS6U0US6A U UC U6S6C U CAS6AU US6A A CS6C US66CS66CS6US6C U- - UIA36 .x.-------------------C A A U US66AS6AS6UU US6A UC C US66C UC A 6AAC6A A CS6C US66CS6CS6U 6CC - - UIA37A.n..------N------A AAUAAU66A UU6SA uccUCCU6S;CUCASSA~US6A A CS6CU66C 6 6CS6US6C U - - IA
38 E.N---. . ----US6S6A A AUS6A C 6AGU IJA U C U C CA 6S6U1AAC 6SCUS CS66U A US6C U- - IA
402... ------ C UC AUS66A6SAS6U UICS6AIU C CUI6C U CIAS66A UI6IA A CS6C U66CS66C A US6CIU-- I A
42H.s.------------------------A AUA 6 6 U USU66UC C UA 6CC U UUC UA U U-(A)6 C UCUUA 6 UA -A 6A- - UIU43Nn.&------------------------- AAA 696U UU66SU C C U6B6CCUUAUA A UU - A(A)U UA6SA6B6UA -ASA A - - UIU461X.1.------------------------ UA AIAS6U UIU6G6U C C UA 6C C U - A AUU - CA --C(A)6U 6-AUA- -A A
A8NAn.-------------------AA AA UU U UG6A UU U6A US6A U6G6CUC 6 A UU[AA C6C U6UC C AASUAC U - - US6
50 P.P. UUA C 66A U 6U AA66AUUCC UU U U UAGA66A6UB6UGAUCUA 6C UU U AUIU A A CG6CUA AUCB66U 6CA - - UIU5iP.t. A CU US66A US6U A A 6A AUUCU U U UUUAA 6 6 U 6A A6A uU UUA A C96CUAA UC AAAU6 C A- -U U
55TZ.*-----------A AUUCUNSUC [1U AU C US6S6C UC A6A A 6 A A C6CUA 6A AU 6 C U - - UNA556L-----------.a U C A UAS6U CAAA A U CU6A6U U UG6A U CCU 6 6C UCAS6AAOJA ACSC U ABC(AU)ANUG6C U- -IUA57UO.s ------AU C A U A6UC NA A AGA6 6NSASU USU6AUC C U6I6C UC A 6A AG A ACS6C UA 6 C(U)A UA U 6CU - - IA
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A6 C C U 6 C AU 6 U C U AA6 U AC ----------6 C AC 6 - H.S. IA6 C C AU 6 C AU 6 U C U A A6 U AC - - - - - - - - - - 6 C AC 6 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - N.M. 2A6 C CA^U 6 C AU 6 U C U A A6 U A C - - - - - - - - - - 6 C AC 6 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R.nr. 3A6 C C AU 6 C AU 6 U C U A A6 U AC - - - - - - - - - - 6 C AC 6 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R.n. 4A6 C C AU 6 C AU 6 U C U A A6 U A C - - - - - - - - - - 6 C AC 6 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - n.c. 5A6 C C A U 6 C A C 6 U 6 U A A6 U A C - - - - - - - - - - 6 C AC 6 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V.I. 6A 6 C C A U 6 C A U 6 U C U A ABU A C - - - - - - - - - - A A 6 C C - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A.S. 7
6CCU6 C ^ U 6U-CU-
6 U U : A C A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S.c. 8A 6 C C A|U 6 C A U 6 U C U A A 6 U A U - - - - - - - - - A A U U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - D.d. 9A 6 C C AU 6 C A U 6 U C U A A 6 U A U - - - - - - - - - - A A 6 U 6 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - n.n. 10A 6 C C AIU 6 C A U 6 U C U A A 6 U A U - - - - - - - - - - A A A U 6 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S.P. 11A C C CA^ U 6 C A U 6 U 6 C C A 6 U U C- - - - - - - - - - A|- U A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T.t. 12A 6 C C A U 6 C A U G U 6 C A 6 UM^U - - - - - - - - - - 6 A A C U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - n.S. 13A 6 C CA^ U 6 C A U 6 U 6 C A A 6 UW^U - - - - - - - - - - 6 A A C U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Z. 0. 14A 6 C C A U 6 C A U 6 U 6 U A A 6 U(A)U - - - - - - - - - - 6 A A C U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 6.9. 1S
A CACA USCA A 6 UcS C6C- CC6C- A.t. 25A C A C A U C A A 6 U C 6 A A C 66UAAC - - - - A 6 6 - U C U U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -P.-t. 26A C A C A U 6 C A A 6 U C 6 A A C 6 6 U A A C A 6 6 A A 6 A - A 6 C U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E.c. 27A C AC A U 6 CA A6 UC 6 A6 C66 U AA C A6 6 A 6 A A - A 6 C U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - P.v. 29A U ACA U 6 C A A 6 U C 6 A 6 C 6 6 A C (-- 6 U)66- A 6 C U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - B.s. 29A C A C A U 6 C AA6 U C6AAC 66 C - -6 6 U U U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - N.c. 30A U A C A U 6CAA6 U C 6 A A C6- - - - - - - - 6 6 6 6 - U 6 C U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - .c. 31A U A C A U 6 CAAUC6A A C 6 - - - - - - - - - 6 6 6 - U 6 C U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - H.S. 32A C A C A U 6 C A A 6 U C 6 A 6 6 A6 UCC A 6 6 A A 6 A A A 6Ic U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A.f. 33
A C A C A U 6 C A A 6 U C 6 A A C 6 C 6 A A -_ - - - A 6 6 - 6E cu - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - n.d 35A C A C A U 6 C A A 6 U IC 6 A 6 c 6 C 6 A A u- - - - - A 6 - 66G C - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M.x. 36A C A C UAU 6 C A A 6 U C G A A C 61~- - - - - - - - - 6 6 C - UCU U - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A.n. 37
4 5
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Nucleic Acids Research
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Nucleic Acids Research
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32' 30' 33
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Nucleic Acids Research
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C C U(A)C C6 AG UUC GAG6 U A CC6 AAACCIAAUUU66 A|C C 6 C 66 A A 6UI---C U C C U(A)C C G6A|U U U 6 A 6 U 6AAC C 6 6 U 6 A AC A U U U166AC C 6 C 6 6 6 6 C U --
C U U 6 U(A)6 UGA A - C 6 A A U 6 6 U C U6 6 A U 66 A 6 C 6 A C A - - - - -
C U C C U(A)C Cl6 AGU U 6 A A U 6 6 UAC C 66 U6 A|A 6 U 6 AUU C 6 6 A|! C 6 C 6 6 C 6(A(C 6 6 6 6 6C U C C U(A)C C6 AU U 6 A A U 6 6 UIC C 6 6 U6 AA 6 U 61U U C 6 6 A C U C 6 6 CICG C - - - A ClC U C C UAAC C AU U 6 A A U 666 C C_6 6 UPA 6 U 6U U C 6 6 A U 6 C 6 6 C 6(A)C 6 u 61A 6
39
16 H.c. U U G C A C A|C A C C G C C C G U C A17 H.h. U U G CI AIC A C C G C C C G U C A18 H.v. U U 6 C|A|C A|C A C C G C C C G U C A19 H... U U GC|AG C A|C A C C G C C C G U C A20 H.h. U U G C|A|C A|C A C C G C C C G U C A21 M.v. U U 6 C[A C A C A C C G C C C G U C A22 M.f. U UG CGA|C A|C A C C G C C C G U C A23 S.s. U UG CCA|C A|C A C C G C C C G U C G24 T.t. U U 6 CAC A|CA C C G C C C G U C G
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6 A6 AAA6IAA
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C A C C 6 C C C 6 U C AC A C C 6 C C C 6 U C AC A C C 6 C C C 6 U C AC A C C 6 C C C 6 U C A|C A C C 6 C C C G U C A
Ic A C C 6 C C C 6 U C A|C A C C 6 C C C 6 U C AICACCGCCCGUCAC A C C 6 C C C 6 U C AC A C C 6 C C C 6 U C AC A C C 6 C C C 6 U C AC A C C 6 C C C 6 U C AC A C C 6 C C C 6 U C A
38 E.g. U U 6 UAC A|C A C C 6 C C C 6 U C A39 C.r. U U 6 U|A|C AIC A C C 6 C C C 6 U C A40 Z... U U 6 U AIC A C C 6 C C C 6 U C A41 M.t. U U 6 UAC A|C A C C 6 C C C 6 U C A
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39
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46 AJC 6 A C A C C C C 6 C A C C A A A LA A AA A U VA A CA A6 A A A U CA U A A C6 A
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45 Lt. A C 6 C A C A C A C C6 C C C 6 U C A C CC U C C U ClA*A A V A 6A U6 Al U C V - - - A A C C C U A U - - - - - - - - - - - - -
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Nucleic Acids Research
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25 A.t. A C UG6(6)6G6U6AGA 6UCG6UA AACAAGGOUAG6C CG6UAWGGG66AA C C UGC 66CAUGG AU C AC C UCCAUUUC A .26 P.t. GWAC UG(6)G6UGAGAOUCG6U A ACA GGUAWC CG6UAUCG6G6AAG6U 6C 6G6C U6 6A UC AC C UC CU UUC A -------27 ECc. 6A C U6(6)GGU6AGAAG6UCGOWAA CAWGGUA AAC CG6OWAGG6GG6A ACC UG6C 66 UGUG6AAUC AC C UC C HA---------2A P.v. 6 ACAU6(6)6G6UG6AA 6AUCG6U A A C AGGA66UA A C CGUAG6G6H6AAC C U6CGUGU6G6A UC AC C U C C UUA --A .---29 RIs. GHAOUUG(G)GGOGAA WGUCG6UAWACWAGAGOUAG6C CGOHUAOUCGG6AWAGGOG6CG6CAUG6A U C AC C UOC CUOUUCO.---30 H.c. A UAUG(G)GG U6GA GOUC OUWAAC HAGAGO6UWG6CCGUA U CGGH6AGAGOG6CG 6C U 6 UC AC C UC CAUUUC U---.
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Nucleic Acids Research
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Nucleic Acids Research
ACKNOWLEDGEMENTS
The present study was made possible by an F.K.F.O. assistantship granted
to E.H.. We thank Erna Dams, Raymond De Baere, Lydia Hendriks, Hilde Van den
Eynde and Peter Willekens for their cooperation in the correction of the srRNA
computer files.
*To whom correspondence should be addressed
REFERENCES1. Torczynski, R.M., Fuke, M., Bollon, A.P. (1985) DNA 4, 283-291.2. Raynal, F., Michot, B., Bachellerie, J.-P. (1984) FEBS Lett. 167, 263-268.3. Torczynski, R., Bollon, A.P., Fuke, M. (1983) Nucl. Acids Res. 11, 4879-
4890.4. Chan, Y.-L., Gutell, R., Noller, H.F., Wool, I.G. (1984) J. Biol. Chem.
259, 224-230 (1984).5. Connaughton, J.F., Rairkar, A., Lockard, R.E., Kumar, A. (1984). Nucl.
31. Iwami, M., Muto, A., Yamao, F., Osawa, S. (1984) Mol. Gen. Genet. 196,317-322.
32. Frydenberg, J., Christiansen,C. (1985) DNA 4, 127-137.33. Weisburg, W.G., Oyaizu, Y., Oyaizu, H., Woese, C.R. (1985) J. Bacteriol.
146, 230-236.34. Same reference as 33.35. Oyaizu, H., Woese, C.R. (1985) System. Appl. Microbiol. 6, 257-263.36. Same reference as 35.37. Tomioka, N., Sugiura, M. (1983) Mol. Gen. Genet. 191,46-50.38. Graf, L., Roux, E., Stutz, E., Kossel, H. (1982) Nucl. Acids Res. 10,
6369-6381.39. Dron, M., Rahire, M., Rochaix, J.-D. (1982) Nucl. Acids Res. 10, 7609-
7620.40. Schwartz, Z., Kossel, H. (1980) Nature 238, 739-742.41. Tohdoh, N., Sugiura, M. (1982) Gene 17, 213-218.42. Eperon, I.C., Anderson, S., Nierlich, D.P. (1980) Nature 286, 460-467.43. van Etten, R.A., Walberg, M.W., Clayton, D.A. (1980) Cell 22, 157-170.44. Kobayashi, M., Seki, T., Yaginumi, K., Koike, K. (1981) Gene 16, 297-307.45. Anderson, S., de Bruijn, M.H.L., Coulson, A.R., Eperon, I.C., Sanger, F.,
Acad. Sci. USA 75, 4801-4805.62. Sor, F., Fukuhara, H. (1980) C.R. Acad. Sci. Paris Ser. D 291, 933-936.63. Nomenclature committee of the International Union of Biochemistry
(1985) Eur. J. Biochem. 150, 1-5.64. Cornish-Bowden, A. (1985) Nucl. Acids Res. 13, 3021-3030.65. Woese, C.R., Gutell, R., Gupta, R., Noller, H.F. (1983) Microbiol. Rev.
73. Schnabel, R., Huet, J., Thomur, M., Zillig, W., Sentenac, A., Stetter,K.O. (1983) in Endocytobiology, vol. 2, pp. 895-912, E.A. Schenk, W.Schwemmler eds., De Gruyter, Berlin, New York.
