“THERE IS NO COMING TO CONSCIOUSNESS WITHOUT PAIN.”
-CARL JUNG
PRINCIPLES OF PAIN MANAGEMENT & ANALGESIA
PRINCIPLES OF PAIN & ANALGESIA
WHAT IS PAIN? An unpleasant sensory or emotional experience associated with
actual or potential tissue damage Pain results when nerve cells in the skin or deep tissues, called
_______________, detect a noxious stimulus
2 types of sensory neurons that detect and transmit pain _________________(large, myelinated)
Transmit sharp, discrete pain signals that allow the patient to localize the source of pain.
transmits somatic pain _________________(small, nonmyelinated)
Transmit dull, aching, throbbing pain that cannot be easily localized
transmits somatic & visceral pain (visceral pain is only transmitted by C fibers)
PRINCIPLES OF PAIN & ANALGESIA
THE PAIN PATHWAY _________________: transformation of noxious thermal,
chemical, or mechanical stimuli into electrical signals called action potentials by A-delta & C fibers
_________________: these sensory impulses are then conducted to the spinal cord
_________________: in the spinal cord where the A-delta & C fibers terminate, the impulses can be altered by other neurons, which either amplify or suppress them.
_________________: the impulses are transmitted to the brain, where they are processed and recognized.
PRINCIPLES OF PAIN & ANALGESIA
WHAT IS PAIN? __________ arises from the skin, soft tissues,
muscles, bones, or jointsEasily localized through stabbing, throbbing,
or aching ___________arises from internal organs
not easily localized and is characterized by cramping or burning
____________term used to describe the pain that is felt in a body part other than where the actual pain stimulus is coming from
PRINCIPLES OF PAIN & ANALGESIA
WHAT IS PAIN? ______________ is increased sensitivity to a stimulus _______________arises from direct damage to peripheral
nerves or the spinal cord. May be shooting, sharp, or tingling
_____________or stump pain is sensation or pain arising from the missing body part
Pain can also be classified according to onset and duration ________ pain has an abrupt onset and a relatively short
duration of action. *Effectively treated with analgesic drugs
________ pain has a slow onset, and duration of several months to years. *May be unresponsive to drug therapy
PRINCIPLES OF PAIN & ANALGESIA
MONITORING SIGNS OF PAIN Consider how we as humans display pain vs. how our
animal patients display pain. Write some ways you can monitor for pain in animals.
PRINCIPLES OF PAIN & ANALGESIA
WHAT ABOUT OUR ANIMAL PATIENTS AND/OR OUR JOBS COULD MAKE MONITORING FOR PAIN DIFFICULT?
PRINCIPLES OF PAIN & ANALGESIA
MYTHS ABOUT PAIN IN ANIMALS Consider how some people without medical
backgrounds may view the animal’s response to pain
PRINCIPLES OF PAIN & ANALGESIA
CONSEQUENCES OF UNTREATED PAIN Consider the long term effects of untreated pain
PRINCIPLES OF PAIN & ANALGESIA
WHAT IS ANALGESIA? ___________ is the absence of the awareness of pain, achieved
through the use of drugs or other modes of therapy. It applies to the relief of pain without the loss of consciousness.
WHAT ARE THE GOALS FOR PAIN CONTROL? Control pain at every stage of treatment to administer analgesics before the patient has an awareness
of pain. This is known as ____________________. Decreases the analgesic requirements Decreases CNS sensitization
To prevent __________ an event caused by a buildup of chemical mediators that intensify the pain response
PRINCIPLES OF PAIN & ANALGESIA
METHODS OF PAIN CONTROL WITHOUT MEDS _______________ are endogenous compounds produced by
the pituitary gland and the hypothalamus that bind to opioid receptors during situations of trauma or stress. They resemble opiates in their ability to provide pain relief and a feeling of well-being. “natural pain reliever”
Nursing care:
Other therapies to control pain:
PRINCIPLES OF PAIN & ANALGESIA
METHODS OF PAIN CONTROL USING MEDS OPIOIDS NSAIDS OTHERS: alpha-2 agonists, ketamine, steroids LOCAL ANESTHETICS
OPIOIDS
MODE OF ACTION: Acts on 4 different receptors in the brain and spinal cord
_______ _______ _______ Sigma(only cause hallucination, euphoria/dysphoria) An opioid agent may act as an _______ (stimulating agent) or __________
(blocking agent) at each receptor Some opioid agents are considered _________________________in that they
block one type of receptor and stimulate another or _______________in that they only partially stimulate some opioid receptors
Binding to these receptors can result in a number of effects: ANALGESIA Respiratory depression Sedation Dysphoria And others,…
OPIOIDS
REVERSIBILITY One major advantage of opioids is their reversibility
with pure antagonists such as ______________, which is the most effective
Naloxone competitively binds to opioid receptors It is also possible to use a mixed agonist/antagonist such
as BUTORPHANOL or a partial agonist such as BUPRENORPHINE to reverse the effects of the pure agonists
CONTROLLED
OPIOIDS
MORPHINE: a FULL AGONIST (stimulates all 4 receptors) Great for moderate to severe pain Produces significant sedation cardiovascular & respiratory depression
SIDE EFFECT/CAUTIONS: Can cause excitement in cats (use lower doses) Often results in ______________ due to its effects on the CRTZ Give slowly IV otherwise severe __________________release can lead to
hypotension and pruritis
Other FULL AGONISTS include oxymorphone, hydromorphone, and fentanyl
OPIOIDS
FENTANYL: a FULL AGONIST (stimulates all 4 receptors) the injectable has a rapid onset of
action and short duration of action. Onset of action: 2 min; duration of effect: 20-30 min
commonly used as a _____________ skin patch Fentanyl is slowly absorbed through the
skin and may take 4-12 hrs in cats, and 12-24 hrs in dogs to reach therapeutic levels
See pg 230 in your book, Procedure 7-1 for instructions on placing a fentanyl patch.
OPIOIDS
BUPRENORPHINE: partial agonist of the mu receptor(aka bupi, buprenex) Delayed onset of action, (40 min IM) but longer
duration of action than other opioids – ___________
Best used for mild to moderate pain The injectable product is effectively given to cats
_____________________ (applied to the gingiva, under the tongue, in cheek pouch)
Can be used to reverse the effects of pure agonists, while maintaining some analgesic effect. Not as effective as naloxone
THIS DRUG IS PART OF THE VTI PROTOCOL FOR DOGS & CATS*
OPIOIDS
BUTORPHANOL: mixed agonist(kappa,sigma)/antagonist (mu)(aka torb, torbugesic) Best used for mild to moderate pain;
and is commonly used as a ________________
Can be used to reverse the effects of pure agonists. Not as effective as naloxone
Commonly combined with a sedative such as dexmedetomidine or acepromazine
MIXING AN OPIOID & SEDATIVE IS KNOWN AS _____________________
OPIOIDS
TRAMADOL: a non-opiate drug that has agonist activity at the mu receptor Oral tablets Useful post-operative pain med in dogs and cats Not currently controlled
NSAIDS
MECHANISM OF ACTION: Inhibits the synthesis of
prostaglandins by blocking the enzyme cyclooxygenase ( aka COX-1 & COX-2) ______ leads to the
production of beneficial prostaglandins
________ leads to the production of harmful prostaglandins that are present during tissue damage and inflammation.
NSAIDS
BENEFITS OF NSAIDS: No strict record keeping Little abuse potential Effective when given orally No sedative, cardiovascular, or respiratory effects Antipyretic effects
SIDE EFFECTS/CAUTIONS: GI upset/GI ulcers due to inhibition of __________
DO NOT USE CONCURRENTLY w/ ___________ ______ toxicity due to inhibition of PGE2 hepatic toxicity Inhibits platelet aggregation due to blockage of
______________
NSAIDS
RIMADYL (carprofen) Approved for use in DOGS ONLY! Oral(chewable tablets) and injectable forms available Less likely to cause side effects mentioned previously
due to its COX-2 selectivity Common uses:
Post-operative pain relief Pain relief from osteoarthritis and other musculoskeletal
injuries
PART OF THE CANINE POST-OP PAIN CONTROL PROTOCOL AT VTI
NSAIDS
METACAM (meloxicam) Approved for use in dogs and cats COX-2 selective Oral and injectable formulations available
PART OF FELINE POST-OP PAIN CONTROL PROTOCOL AT VTI
ALPHA-2 AGONISTS & KETAMINE
ALPHA-2 AGONISTS (ex: dexdomitor, xylazine) Short duration of action (~90 minutes) Also causes profound sedation, bradycardia Commonly combined with butorphanol Reversible (analgesic effects are reversed as well)
KETAMINE Works by antagonizing ____________receptors in the spinal
cord Blocking NMDA receptors prevents central sensitization &
windup Effective for _________analgesia, but limited visceral
analgesia Duration of action is short 30min
LOCAL ANESTHETICS
WHAT IS LOCAL ANESTHESIA/ANALGESIA? The use of a chemical agent on sensory neurons to
produce a disruption of nerve impulse transmission, leading to temporary loss of sensation
LOCAL ANESTHETICS
CHARACTERISTICS OF LOCAL ANESTHETICS Exert their effects on neurons in the peripheral
nervous system and spinal cord that control pain, heat, cold, & pressure
Relatively few effects of the cardiovascular and respiratory systems
Exert their effects in the area closest to the site of injection
Not normally transferred across the placenta Safe for c-sections
LOCAL ANESTHETICS
ROUTES OF ADMINISTRATION TOPICAL: must penetrate the epidermis to reach the
dermis where the peripheral nerves are located Sprayed on intact skin for superficial procedures such as
skin biopsies (ex: ethyl chloride) Creams can also be applied to desensitize skin for
superficial minor procedures (ex: lidocaine/prilocaine) Splash blocks refer to the use of sprays or anesthetic soaked
gauze sponges on open wounds or surgical sites Applied through a chest tube in patients having thoracic
surgery Should be done when patient is awake
Absorbed through the mucous membranes (larynx, eye, urethra)
Short duration of action and less pain relief when compared to other routes of administration of local anesthetics
LOCAL ANESTHETICS
ROUTES OF ADMINISTRATION: INFILTRATION(injection):
Local anesthetic can be injected subcutaneously, intradermally, or between muscle planes
Ideally the site of injection is clipped and cleaned Small needle (23-25 gauge) used to prevent tissue damage Test efficacy by pricking the site with a needle Do not inject into infected or inflamed tissues
Some local anesthetic drugs are combined with epinephrine Epinephrine causes vasoconstriction which decreases rate of
absorption and prolonging effect It also decreases the amount of drug entering the circulation,
decreasing chances of toxicity. CAUTION AROUND AN INCISION OR ON EXTREMITIES
AND WITH PATIENTS WITH CV ABNORMALITIES
LOCAL ANESTHETICS
ROUTES OF ADMINISTRATION _________ BLOCKS: Injection of a local anesthetic in the
proximity of a specific nerve to desensitize a specific anatomic location. Location of target nerve must be known and palpated if possible. Lameness exams in horses Cornual blocks for dehorning cattle Dental blocks in dogs and cats Infiltration of nerves during amputation of a limb Declawing cats
May take 15-20 minutes for absorption Nerve blocks include ________ blocks and ______ blocks
NERVE BLOCKS
Paravertebral block
Nerve blocks help pinpoint areas of pain
THESE ARE EXAMPLES OF LINEBLOCKS
LOCAL ANESTHETICS
ROUTES OF ADMINISTRATION NERVE BLOCKS
LINE BLOCKS: continuous line of local anesthetics placed SQ in an area served by numerous small nerves The needle is inserted along the line of infiltration and
the anesthetic is injected as the needle is withdrawn If placed encircling an anatomic part, it is called a
RING BLOCK
_________________: injecting local anesthetics directly into a joint usually after surgery of the joint, immediately after closure of the joint capsule
LOCAL ANESTHETICS
ROUTES OF ADMINISTRATION ____________: blockage of sensory and motor nerves in
the rear, abdomen, pelvis, tail, hind limbs, and perineum Anesthetist must be familiar with the anatomy of the
terminal spinal cord and lumbosacral vertebrae
Spinal cord
Pia materSubarachnoid space w/CSF
arachnoidDura mater
Epidural space
LOCAL ANESTHETICS
EPIDURALS
http://www.youtube.com/watch?v=zmwvMHZG_5g
SIDE EFFECTS OF LOCAL ANESTHETICS
Allergy Rash or hives in the area
Systemic toxicity Sedation, nausea, restlessness, hyperexcitability,
seizures, respiratory suppression, comaInfection (esp. w/epidurals)Cranial infiltration of an epidural may cause
serious toxicity, respiratory suppressiondeath