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Complement Assigned Reading Content Outline Performance Ojectives
– Key terms– Key Concepts
Short Answer Questions
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Content Outline Complement Components Complement Activation Regulation of Complement Biological Consequences Complement Deficiences
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Biological Consequences Cell lysis Inflammation Opsonization Viral neutralization Solubilization of immune
complexes
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Key Terms alternative pathway anaphyltoxin
inactivator anaphylatoxins C1 C1q C1r C1s C1 inhibitor (C1-INH), C2 C2a C2b
C3 C3a C3b C3 convertase C3b/C4b receptor(CR1) C4 C4a 4b
C4 binding protein (C4-bp)
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C5 C5a C5b C5 convertase C6 C7 C8 C9 CD59 classical pathway amplification phase
activation phase membrane attack phase
complement complement system
Factor B Factor D Factor H Factor I
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Key Concepts Describe the nomenclature of
complement components Draw a concept map of the classical
complement cascade Draw a concept map of the alternate
pathway of complement activation Describe with specific examples the
regulation of complement activation
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Discuss why the amplification phase in critical to many immune reactions.
Specify the major sources of complement and comment on the genetic control of complemt proteins
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Complement is involved in antigen-antibody interactions, yet there is no agglutination or precipitation. What does happen?
What are the important functions of complement?
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Differentiate between the classical pathway and the alternate pathway of complement activation
Briefly discuss the three stages of the classical pathway of complement activation. What stage is the most important? Why?
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What is the difference between complement activation by antigen-IgM complexes and antigen-IgG complexes?
What is the biologic importance of C4a?
What complement components make up C3 convertase and what does it do?
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Macrophages have receptors for C3b. What is the biologic significance of this fact?
What is the last complement component to be split into two biologically active fragments? What are their functions?
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If the complement cascade is stopped before the membrane attack phase, has complement fulfilled its function in an immune response?– If Yes, Why?– If No? Speculate on the reason for
having the membrane attack phase?
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What components of the complement system are shared between the classical pathway and the alternative pathway?
Why is it important to tightly control complement activation?