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BioMEMS
Enabling Killer Apps inHealthcare & Lifestyle
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Chronic diseasesstem in large partfrom lifestyle related
risk factors
BioMEMSEnabling Killer Appsin
Healthcare & Lifestyle
Chris Van Hoof, imec, Belgium
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LAST MONTH
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I LEARNED ABOUT MYHEALTH RISKS
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Chronic diseasesstem in large partfrom lifestyle related
risk factors
HEALTH=
Genetics
Bill Davenhall, geo-medicine guru, ESRI
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LANDSCAPE OF POC DX
Type Benchtop Portable Smartphone
Where? Clinical lab Clinical lab or Drsoffice
Home or Drs office
What? Expensive and dedicatedinstrument, low-costdisposable
Lower cost dedicatedinstrument, low-cost
disposable
No instrument. Morefunctions integrated into
disposable. Data processing
in smartphone or cloud.
Instrument cost $10-100k $5-20k $0
Disposable cost $10-200 $10-200 $0.50-10
Well-servicedSolutions exist
Nocompelling
solutions on
the market
yet
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disposablemicrofabricated
test
flexible:blood,saliva,
urine
smartphone
healthtracking
app +
webservices
iLabTECHNICAL CONCEPT
Wireless link
ONE PLATFORM - MANY MARKERS
DNA/RNA Mutations miRNA: marker for cancer and other diseases Pathogen DNA/RNA: infectious diseases (HepC,
HIV, et.)
Proteins Biomarkers for disease (cancer, Alzheimers,
infectious diseases, heart disease, etc.)
Small molecules and metabolites Metabolic information (e.g. cholesterol)
Microscopy Blood cell count (e.g. HIV CD4+) Blood disorders (e.g. sickle cell anemia)
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disposablemicrofabricated
test
flexible:blood,saliva,
urine
smartphone
healthtracking
app +
webservices
Detection chip
~1 cm
2-4 cm
Fluidics chip
PCB with
radio,
power,
control
Package
Exploded view
iLabTECHNICAL CONCEPT
Wireless link
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200MM BIOMEMS WAFER
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inlets outlet
MICRO-PILLAR ARRAY FILTER
Injection volume
200m
supply
c
hannel
distributor
micro-pillars
50m 5m
injection area distribution area separation area
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Chip-PCR
Conv.PCR
MICRO-REACTOR FOR DNA
AMPLIFICATION
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http://www.diginfo.tv/v/13-0022-r-en.phpPanasonic-imec result
HALF CREDIT CARD SIZE BIOMEMSachieving on-chip DNA amplification and detection from whole blood sample
SEPARATION OF 11 DNA STRANDS IN 2CM LONG CHANNELDNA fragments are 10, 15, 20, 25, 35, 50, 75, 100, 150, 200 and 300bp
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Chronic diseasesstem in large partfrom lifestyle related
risk factors
HEALTH=
Genetics+Lifestyle
+ Environment
Bill Davenhall, geo-medicine guru, ESRI
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Chronic diseasesstem in large partfrom lifestyle related
risk factors
3lifestyle-related RISK FACTORS
are responsiblefor all chronic diseases
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PREVENTIONTRACK RISK FACTORS & ADAPT LIFESTYLE
Raised blood pressure
Raised blood glucose
Overweight/obesity
Abnormal blood lipids
Unhealthy diet
Physical inactivity
Tobacco use
Behavioral / lifestylerisk factors
GENETICS
ENVIRONMENT
Intermediate risk factors
Heart disease | Stroke | Cancer |Chronic pulmonary diseases | Diabetes
MAIN CHRONIC DISEASES
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REDUCING DIABETES AND
HYPERTENSION PREVALENCEBY 5% WOULD SAVEAPPROXIMATELY
$9 BILLION ANNUALLY IN THENEAR TERM
PREVENTION WORKS !
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Reviewo
ver1Mp
eople
Source:Wo
odcocketal,Int
JofEpidemiolog
y,2010Reduction in global risk
mortality by increasingphysical activity
PREVENTION WORKS !
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Totalexpenditur
eonheal
th,
%
GDP
OECD dataad
1970 1980 1990 2000 2008
16
14
12
10
8
6
4
UNITED STATES
GERMANY
SWITZERLAND
UNITED KINGDOM
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Technology should
EMPOWERpeople towards
disease prevention
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QUALITY OF DATA
DESIRABLEFORMFACTOR
LOWCOST
LOWPOWER
REQUIRES RADICALINNOVATIONS
inSENSOR, CIRCUIT, SYSTEM, INTEGRATION
TECHNOLOGY, ALGORITHM & DATA ANALYTICS
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KILLER APPS
THAT
SAVE LIVES
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Chronic diseasesstem in large partfrom lifestyle related
risk factors
KILLER APP #1
STAY FIT
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18kcal/kg/day 4.3kcal/kg/day
THE ADVERSE EFFECT OF
EVOLUTION
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WITH DRAMATIC CONSEQUENCES
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NEEDS A BEHAVIOR CHANGE
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A MULTITUDE OF DEVICES
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IMEC CIRCUITS SYSTEMS &
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IMECs CIRCUITS, SYSTEMS &ALGORITHMS FOR ENERGY EXPENDITURE
90%Accuracy
Reliablein everyday situations
1 monthAutonomy
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GRAND CHALLENGE: ENERGY INTAKE
imec HYPERSPECTRAL SENSOR
imec PHYSIOLOGICAL SENSOR
CHANGING BEHAVIOR IS TOUGH
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CHANGING BEHAVIOR IS TOUGH
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Chronic diseasesstem in large partfrom lifestyle related
risk factors
KILLER APP #2
MANAGESTRESS
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Stressed person
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30-40%
25%
4/10
$42-300B
STRESS MANAGEMENT APPS
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STRESS MANAGEMENT APPS
STRESS BIOMARKERS
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Sympathetic
and
Parasympathetic
Autonomic
Nervous
System
Heart rate
Respiration rate
Salivation
Perspiration
Pupil dilation
STRESS BIOMARKERS
EMERGING t l
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EMERGING tools
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Parametersmeasured today
Skin conductance3D-accelerometerSkin temperatureSkin humidityAmbient
temperature
Ambient humidity
STRESS AT WORK STRESS PATIENTS
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STRESS AT WORK
80% accuracyin classifying stress from rest
STRESS PATIENTS
75% accuracyin classifying patients from controls
SALIVA STRESS SENSOR
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SALIVA STRESS SENSOR
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Chronic diseasesstem in large part
from lifestyle related
risk factors
KILLER APP #3
DISPOSABLEHEALTH PATCH
REDESIGN FOR
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ROLL-TO-ROLLMANUFACTURING
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TAKEAN IMEC WIRELESS SENSOR DESIGN
ADAPT IT FOR FOIL INTEGRATION
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ADAPT IT FOR FOIL INTEGRATION
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INTEGRATE PASSIVES AND ICS
LOW-COST
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LOW COST
SKIN TEMPERATUREPATCH
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Chronic diseasesstem in large part
from lifestyle related
risk factors
HEALTH
=
Genetics+ Lifestyle
+ Environment
Bill Davenhall, geo-medicine guru, ESRI
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Chronic diseasesstem in large part
from lifestyle related
risk factors
KILLER APP #4
KEEP YOUR
ENVIRONMENT IN
CHECK
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imec ENVIRONMENTAL NO2 SENSOR
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imec ENVIRONMENTAL NO2 SENSOR
CONTINUOUSMEASUREMENT
at ambient temperature
in varying humidity
EMERGING ppb NO2 MONITORING
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2
12 14 16 18 20 22-120
-100
-80
-60
-40
-20
0
Time (hours)
Relativeresponse(%)
Parking garage
Clean air in nature
EMERGING environmental MONITORING
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Chronic diseasesstem in large part
from lifestyle related
risk factors
Basic NOSE functionality: array of eNose sensors on single chip
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MEDICALQUALITY
DATA
IN
CONSUMERHANDS
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Technology
mustEMPOWERPEOPLE
towards disease prevention and towardsa healthier lifestyle
ENCOURAGE & MOTIVATE
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BioMEMSEnabling Killer Apps in
Healthcare & Lifestyle