An unsuspected, underdiagnosed
Endocrine
Immune mechanism causing disease in animals and humans.
PART I
I have studied and treated as many as 50,000
endocrine-immune cases in dogs, cats and horses.
What I have found is underdiagnosed or perhaps
unrecognized, or an unsuspected mechanism that
creates disease.
These cases vary from simple allergies to autoimmunity
and cancer.
It appears that a similar syndrome is found in humans called CVID (Common Variable
Immunodeficiency).
CVID appears to vary from allergies to autoimmunity
and cancer.
EI patients that I have treated all have
(a). Deficient or bound cortisol(b). Elevated total estrogen(c). Deficient or bound T3T4(d). Immunodeficient or
immunoderegulation of B & T cells
Is there a first domino that falls allowing for EI Syndrome or possible CVID Syndrome?
In animals, the 1st domino to fall is Cortisol.
What causes this Zona Fasciculata failure?
(a). Genetic damage(b). Acquired damage
This EI Syndrome can be diagnosed with blood tests in
puppies, kittens & foals as early as 4 to 6 weeks of age!
The parents of the offspring can be tested and identified as the
culprits before Breeding, enabling the prevention of
EI Syndrome in the offspring.
Acquired damage to the Zona Fasciculata may occur due
to toxicological sensitivity of this layer.
(+/- environmental toxins, vaccines, anesthesia, ingested
pharmaceuticals).
In animals, it is rare to see complete adrenal cortex
damage! Usually it is the cortisol level that is affected either
temporarily or permanently.
Quote Harvey on the toxicological sensitivity of the adrenals and particularly
the cortex as an unappreciated factor. According to British toxicology expert
Philip Harvey, in The Adrenals in Toxicity: Target Organ and Modulator of Toxicity, the adrenal gland is the most vulnerable organ in the endocrine system for toxins,
and within the adrenal gland “the majority of effects” have been observed
in the cortex. Such disturbances can “fundamentally affect the whole body
physiology and biochemistry”.
In personal communication, Harvey has told me that surveys of toxicity within the endocrine system indeed reveal that the
adrenal cortex is a very common target and factors predisposing this are at its large blood supply per unit mass, Lipophilicity and
it is also rich in cytochrome P450 enzymes.
Hans Selye’s work on stress, recognized in General Adaptation
Syndrome that chronic stress would cause adrenal exhaustion
and lead to an EI Syndrome. I also published these findings in animals in 1978. In this published
paper, I theorized that in the production from dopa to
norepinephrine, cortisol appeared to be used as a catalyst.
Selye prescribed cortisol to help people, which was successful for a while, but then moved into an
over adaptation phase which often recreated the original syndrome with the chronic
stress it caused.
In Dogs with chronic stress, thyroid supplementation with
cortisol for the EI Syndrome will be necessary for improvement.
Without thyroid supplementation, the syndrome would improve temporarily but
eventually return, due to cortisol replacement going from a
physiological dose level into a pharmacological dose level, leading to over adaptation.
What is occurring with a defective zona fasciculata?
What then does excess estrogen do?
(a). Acts like histamine – Therefore causing
inflammation(b).Binds T3T4(c). Binds cortisol (bound cortisol
disallows transferance from T4 – T3
(d).Deregulates B + T Cells
REMEMBER, THE ENDOCRINE SYSTEM REGULATES THE
IMMUNE SYSTEM IN ANIMALS. USUALLY THESE SYSTEMS DO
NOT ACT INDEPENDENTLY.
If you find similarities between an EI Syndrome on CVID
common variable syndrome, then your measuring stick is
identifying factual B cell antibody levels and correcting
them and the disease with proper hormone therapy.
Remember, each patient will and should be different.
I had to create my own clinical norms for IgG, IgM & IgA.
You will need to do this also.
The IgA level will determine if malabsorption is present and
whether oral hormone replacement will effectively
normalize the immune system.
T cell regulation usually accompanies B cell regulation.
Some of you here are familiar with the concept of low-dosage,
long term cortisone.Others may be appalled by any thought of long-term cortisone.
Among us here is William Jefferies, M.D., who has pioneered for decades the practice of
long-term, low-dosage cortisone replacement that is both safe and hugely effective for allergies, chronic fatigue, and rheumatoid
conditions. Other physicians have started to realize as well that cortisone, at low dosage, can be a major long term therapy modality.
At pharmacologic dosages, it is indeed immunosuppressive. However, at physiologic
low-dosage level, in the presence of a cortisol deficiency, which I believe is
extremely common among people because of a combination of genetic, toxicity, and
prolonged stress, this great healing medicine.
Dr’s Barnes and Hertoghe Identified the importance of thyroid therapy in humans.
With my EI syndrome in animals, in particular dogs, I have found
that proper thyroid supplementation will guarantee
keeping cortisol supplementation at a
physiological regulatory level and correct this EI Syndrome.
The next hour will discuss clinical testing and
supplementation of the EI Syndrome.
An unsuspected, underdiagnosed
Endocrine
Immune mechanism causing disease in animals and humans.
PART II
Phase 1 protocol – Blood
MALE:Blood CortisolTSHT3T4Total EstrogenTestosterone (total & free)IgA, IgM, IgG
FEMALE:Blood CortisolTSHT3T4Total EstrogenProgesteroneTestosterone (total & free)FerritinIgA, IgM, IgG
Phase 1 protocol – Urine
MALE:24 hour urine
collection1. Active Cortisol2. Free T33. Free T4
FEMALE:24 hour urine
collection1. Active Cortisol2. Free T33. Free T4
Phase 1 protocol – Basal Metabolic Temperature
MALE:Upon waking, place
thermometer in axilla for 10 minutes before getting up.
Normal temperature should be 97.8 – 98.2 degrees.
FEMALE:Upon waking, place
thermometer in axilla for 10 minutes before getting up.
Normal temperature should be 97.8 – 98.2 degrees.
Only accurate in a menstruating woman from 2nd to 4th day.
In my experience with dogs,I have found that a physiological
dose level of cortisol may become a pharmacological dose
level if used without thyroid supplementation.
If this fact is true, then what happens to any hormone
supplementation? In canines and humans, that must be a concern about a pharmacological build
up of a particular hormone causing various hormone cycles
resulting in damage to our patients.
If with CVID – common variable immunodeficiency syndrome,
how do you determine a normal immune measuring stick with
the different laboratory normals that are now available?
I analyzed reference ranges from 15 major human medical labs.
Many laboratories used the same lab kits for the immunoglobulin, yet there are wide discrepancies in what these laboratories regard
as normal.
These are the variable ranges for normal ranges according to
each to each laboratory:
IgG results from various human laboratories
IgM results from various human laboratories
IgA results from various
human laboratories
Based upon these results, you definitely need an international standardized reference range on an international basis that
you create!
By removing the high & low and possibly removing 10% of the lower and higher levels, your
immune measuring stick may be closer to being accurate.
IgG 700 - 1500mg/dl
IgM 50 - 200mg/dl
IgA 70 - 350mg/dl
Obviously, as you normalize your patients, these values will
be modified based on your clinical results.
This is merely an attempt to show you that depending on the
variability of the lab test results your patient may be normal or highly abnormal, which would
lead to improper therapy based upon inaccurate laboratory
results.
My EI Syndrome and possibly your CVID Syndrome relates from simple allergies to all
autoimmune disorders and all cancers in animals.
Finally, remember, in all animals with cancer, there is deficient or
bound cortisol, elevated total estrogen, deficient transfer defect or bound T3T4 and deregulated B & T cells.
Fortunately, you and I practice for our patient first, and our
profession second.