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Presentation Point of View
1. Rationality of Insulin Therapy for Type 2 DM
2. What is Analogue Insulin?
3. How & strategy of Insulin treatment ?4. Barrier of using insulin
5. Take Home Message
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Normal islet cell
Deposition of amyloid
in T2DM
Natural History of Type 2 DM
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Insulin
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OAD :Kegagalan sekunder sesudah beberapa tahun
ADOPT: Kahn SE et al. N Engl J Med2006;355:2427-43.
8.0
7.6
7.2
6.8
6.4
6.0
0
0 1 2 3 4 5
Time (Years)
HbA1c
(%
)
Rosiglitazone
Metformin
Glybenclamide
ADOPT study
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UKPDS 57:Adapted from Wright A et al. Diabetes Care 2002;25:330-6.
Early Addition of Insulin
Can Optimize Glycemic Control
50
25
0
p=0.011
ProportionofPatientswithHbA1c