ANTIMICROBIAL AGENTS ANDCHEMOTHERAPY
VOLUME 25 * JUNE 1984 NUMBER 6
Leon H. Schmidt, Editor in Chief (1985)University ofAlabama in Birmingham
BirminghamHerbert L. Ennis, Editor (1987)
Roche Institute ofMolecular BiologyNutley, New Jersey
Robert L. Hamill, Editor (1985)Eli Lilly & Company, Inc.
Indianapolis, Indiana
George A. Jacoby, Jr., Editor (1985)Massachusetts General Hospital
BostonRobert C. Moellering, Jr., Editor (1987)New England Deaconess Hospital
Boston, Massachusetts
Peter G. Welling, Editor (1988)Warner-Lambert Co.Ann Arbor, Michigan
EDITORIAL BOARD
John A. Washington II, Editor (1986)Mayo Clinic
Rochester, Minnesota
Norris Allen (1986)Vincent T. Andriole (1984)John P. Anhalt (1984)Bascom F. Anthony (1985)George R. Aronoff (1986)Robert Austrian (1986)Richard H. Baltz (1984)Rashmi H. Barbhaiya (1986)Arthur L. Barry (1986)John D. Bartlett (1984)Michael Barza (1985)John E. Bennett (1984)Richard F. Bergstrom (1985)Gerald P. Bodey (1986)Lawrence E. Bryan (1985)Ward Bullock (1984)Tsun Chang (1986)Anthony Chow (1985)C. Glenn Cobbs (1986)Paul S. Cohen (1986)William A. Craig (1984)Naomi Datta (1984)Lawrence E. Day (1986)William E. Dismukes (1984)R. Gordon Douglas, Jr. (1986)John C. Drach (1984)Theodore Eickhoff (1985)Gertrude B. Elion (1984)Arthur English (1986)
Robert J. Fass (1985)Stuart Feldman (1985)Sydney Finegold (1985)Robert J. Fitzgerald (1986)Martin Forbes (1986)Dale N. Gerding (1985)David Gilbert (1984)Anthony J. Glazko (1984)Irving H. Goldberg (1985)Richard H. Gustafson (1984)Jack Gwaltney (1986)Scott M. Hammer (1986)W. Lee Hand (1986)H. Hunter Handsfield (1986)Maurice W. Harmon (1984)Joseph Hawkins, Jr. (1985)Michael Higgins (1986)Richard Hornick (1986)George Gee Jackson (1986)James H. Jorgensen (1984)William J. Jusko (1986)A. W. Karchmer (1985)Donald Kaye (1985)George S. Kobayashi (1985)Donald J. Krogstad (1986)Felix Leitner (1986)Stephen A. Lerner (1986)Matthew E. Levison (1984)
Stuart B. Levy (1986)Friedrich C. Luft (1984)Joan Lusk (1986)R. Luthy (1986)Francis L. Macrina (1985)Gerald L. Mandell (1986)Gary R. Matzke (1986)George H. McCracken (1984)Gerald Medoff (1986)Michael Miller (1984)Barbara Minshew (1985)Bernard Moss (1984)Thomas P. Moyer (1986)Barbara E. Murray (1984)John D. Nelson (1986)Harold C. Neu (1986)James T. Park (1985)James E. Pennington (1986)T. J. Perun (1986)Lance R. Peterson (1985)Burton M. Pogell (1984)Michael Rein (1986)W. H. G. Richards (1986)Richard Roberts (1985)Ian M. Rollo (1985)Richard Root (1986)John P. Rosazza (1986)Jon E. Rosenblatt (1985)
Merle Sande (1985)Christine C. Sanders (1984)W. Eugene Sanders (1984)W. Michael Scheld (1986)Jerome J. Schentag (1985)Raymond F. Schinazi (1986)Fritz D. Schoenknecht (1986)F. C. Sciavolino (1985)William M. Shannon (1986)Charles Shipman, Jr. (1985)Robert W. Sidwell (1984)P. Frederick Sparling (1984)Harold Standiford (1985)David A. Stevens (1986)R. Sutherland (1985)Vera L. Sutter (1984)Morton N. Swartz (1985)Richard B. Sykes (1985)Francis P. Tally (1984)Alexander Tomasz (1985)Ralph Tompsett (1985)Francis L. S. Tse (1986)Michael Waring (1984)Bernard Weisbium (1985)Richard M. Welch (1986)Richard Wise (1986)Lowell Young (1985)Pauline K. W. Yu (1985)
Helen R. Whiteley, Chairman, Publications BoardLinda M. Illig, Managing Editor, Journals
Walter G. Peter III, Director of PublicationsDeborah J. Shuman, Production Editor
Antimicrobial Agents and Chemotherapy (ISSN 0066-4804), an interdisciplinary publication of the American Society for Microbiology,1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects of antimicrobial, antiparasitic, andanticancer agents and chemotherapy. Instructions to authors are published in the January issue each year; reprints are available from theeditors and the Publications Department. Antimicrobial Agents and Chemotherapy is published monthly, and the twelve numbers are dividedinto two volumes per year. The nonmember subscription price is $157 per year; single copies are $21. The member subscription price is $31(foreign, $41 [surface rate]) per year; single copies are $7. Correspondence relating to subscriptions, reprints, defective copies, availability ofback issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM PublicationsDepartment, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680).Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication ofthe issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing becauseof failure to report an address change or for issues "missing from files" will not be allowed.Second-class postage paid at Washington, DC 20006, and at additional mailing offices.POSTMASTER: Send address changes to Antimicrobial Agents and Chemotherapy, ASM, 1913 I St.. NW, Washington, DC 20006.Made in the United States of America.Copyright © 1984, American Society for Microbiology. H*: 14ltS* ii e ;11wl* ( Fl4u.All Rights Reserved.The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may bemade for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the statedper-copy fee through the Copyright Clearance Center, Inc., 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, foradvertising or promotional purposes, for creating new collective works, or for resale.
Author Index
Ackerman, Bruce H., 785Actor, Paul, 694Apolloni, E., 760Arosio, E., 760
Baron, Ellen J., 781Barry, Arthur L., 710, 775Bayer, Arnold S., 725Bedows, Elliott, 719Benoni, G., 760Borowski, E., 772Bryan, L. E., 747
Campos, Jose, 706Catlin, B. Wesley, 676Chin, Nai-Xun, 687
Davidson, Bruce A., 719De Broe, Marc E., 783Devos, J., 764Dubreuil, L., 764Dunn, George L., 694
Eisenstadt, Rosalee, 725
Garcia-Tornel, Santiago, 706Giuliano, Ruben A., 783
Gotoh, Akira, 754Grappel, Sarah F., 694Grossman, Dena M., 690Guymon, L. F., 767
Hastie, Annette T., 673Higgins, Michael L., 673Hindler, Janet A., 781
Jakas, Dalia R., 694James, Philip R., 735Jenkin, H. M., 772Jones, Ronald N., 710, 775
King, John W., 770Knight, Paul R., 719Knight, Vernon, 729Kobasa, William D., 683Konno, Masatoshi, 754Kramer, Michael J., 729Kueppers, Friedrich, 673
Labthavikul, Pornpen, 687Lechi, A., 760Lentino, Joseph R., 778Levison, Matthew E., 683Lind, I., 767
Malewicz, B., 772Momsen, M., 772Morrison, Joan O., 725Myers, William F., 690
Neu, Harold C., 687Neut, C., 764
Parr, Thomas R., Jr., 747Parrillo, Patricia, 778Passarella, E., 760Penn, Robert L., 770Phillips, Lillian, 694Pitkin, Donald, 694Pollet, Dirk E., 783
Raimondi, M. G., 760Romond, C., 764Ross, Janette, 785Rotschafer, John C., 785
Sakuma, Takashi, 742Sanfeliu, Isabel, 706Scharpe, Simon L., 783Shafer, W. M., 767Sparling, P. F., 767
Stachowski, Michael, 778Strikas, Raymond, 778Sun, Chong-Son, 729
Tannenbaum, Charles S., 673Thornsberry, Clyde, 710Tofte, Robert W., 785
Ubukata, Kimiko, 754
Vaara, M., 701Velo, G. P., 760Verbist, Ludo, 783Verpooten, Gert A., 783Viljarten, P., 701Vosbeck, Klaus, 735
Weinbaum, George, 673Wilson, Samuel Z., 729Wisseman, Charles L., Jr., 690Wyde, Philip R., 729
Yamashita, Naoko, 754
Zimmermann, Willy, 735
AUTHOR INDEX
VOLUME 25
Ackerman, Bruce H., 785Ackers, Irene, 579Actor, P., 373Actor, Paul, 694Adejuyigbe, Olusanya, 497Adkinson, N. Franklin, Jr., 93Ahmed, S. Masud, 643Akhter, S. Q., 643Albritton, William L., 187, 296Alford, Robert H., 405Anderson, Burt, 296Andreana, Augusto, 182Andrews, J. M., 612Andritz, Mary H., 33Angehrn, Peter, 607Apolloni, E., 760Arbeter, A. M., 417Arceneaux, Jean E. L., 650Arcey, Sergio M., 16Arndt, Kenneth A., 553Aronoff, George R., 513Aronoff, Stephen C., 279Arosio, E., 760Asahi, Yoshinari, 131Ash, Ronald J., 443Assael, Baroukh M., 395Auerbach, Jeffrey I., 622Auger, Franqois, 662Austin, Thomas W., 455Ayers, L. W., 633Ayers, Leona W., 669Ayrton, John, 78Azegami, Masao, 146
Baba, Masanori, 515Baker-Zander, Sharon A., 390Ballard, James O., 153Baltch, Aldona L., 33, 488Bannatyne, Robert M., 537Barge, Janine, 168Barlam, Tamar, 529Barnes, Scott G., 153Baron, Ellen J., 781Baron, Jody L., 646Baron, Samuel, 646Barrueco, M., 458Barry, A. L., 633Barry, Arthur L., 392, 669, 71
775Bartus, Henry R., 622Barza, Michael, 655Baxter, Heather, 306Bayer, Arnold S., 725Beaulieu, Bernard B., Jr., 65Bedows, Elliott, 719Beggs, William H., 316Beight, Douglas W., 443Belsheim, Judy, 179Benoni, G., 760Berens, Randolph L., 292Berliner, Daniel, 7Berman, Steven J., 438Bianchi, P., 666Biddle, James, 296Bieth, Gilda, 289Blase, David K., 513Blevins, Roger D., 603Blok-Perkowska, Danuta, 134Blomqvist, Charlotte, 179Blumer, Jeffrey L., 579Bondi, Joseph V., 238
Bongaerts, Ger P. A., 234Borner, K., 105Borobio, M. Victoria, 342Borowski, E., 772Borsa, F., 638Bosso, John A., 630Boutwell, M. E., 650Bouzos, John, 534Bright, Gene M., 113Brion, Nils, 168Brook, Itzhak, 71Brown, Daniel R., 422Brown, Douglas, 286Brown, Timothy H., 405Brumfitt, W., 276Bryan, C. S., 37Bryan, L. E., 382, 747Buesing, Mary A., 283Butler, Thomas, 643Buu-Hoi, Annie, 289Byers, B. R., 650
Cabezudo, Ignacio, 4Cable, Douglas C., 258Campbell, Gwendolyn S., 205Campos, Jose, 706Campos, Joseph M., 327Carbon, Claude, 168, 618Cardinal, J. R., 10Carr, Douglas, 539Carter, Walker T., 162Casalino, M., 499Catlin, B. Wesley, 676Chan Lee, Huei, 146Chau, Nguyen Phong, 618Cheung, Rose, 537Chiemchanya, Surang, 273Chin, Nai-Xun, 319, 687Chopra, Ian, 446Chou, Sunwen, 25Cohn, Naomi K., 292Coleman, William G., Jr., 539Collins, Shirley H., 301Comanducci, A., 499Congeni, Blaise L., 40Conroy, Joseph V., 33Contrepois, Alain, 168, 618
10, Coolbaugh, James C., 71Coppenhaver, Dorian H., 646Correia, Ricardo A., 653Crooke, Stanley T., 622Crossley, Kent B., 532Crumpacker, Clyde S., 247, 553Culbert, Steve, 62
Daneshmend, Tawfique K., 1Davidson, Bruce A., 719Davies, Mary-Ellen M., 238Davis, Donald R., 20De Broe, Marc E., 783De Clercq, Erik, 566DeClercq, Erik, 515DeGirolami, P., 401Deneer, Harry G., 187Denoya, Claudio D., 659Devlin, Richard G., 358Devos, J., 764Dewsnup, Daniel H., 165Dilillo, Mariantonia, 182Diven, Warren, 473Dominguez-Gil, A., 458
Dotzlaf, Joe E., 216Dromer, Francoise, 168Dubois, Catherine, 168Dubreuil, L., 764Dunn, George L., 694Dworzack, David L., 494Dylewski, Joe S., 25
East, Donald S., 83Eby, George A., 20Echols, Roger M., 336Egbert, Peter R., 25Eisenstadt, Rosalee, 725Elion, Gertrude B., 507Eliopoulos, G. M., 331, 401Eliopoulos, George M., 398Elvers, A., 105Ene, Mokelu D., 1Eng, Robert H. K., 510English, A. R., 118English, Arthur R., 113, 226, 599Eppstein, Deborah A., 563
Fadl-Allah, Nora, 375Fainstein, V., 387Falkinham, Joseph O., III, 137Farber, Bruce F., 398Fasching, Claudine E., 58, 545,
596Fass, Robert J., 408Field, A. Kirk, 238, 247Fillastre, J. P., 638Finegold, Sydney M., 162Fischer, Philip R., 502Fite, Laurie D., 443Fliegelman, Robert M., 504Florioli, Alessandra, 395Flynn, Gary A., 443Foglesong, Mark A., 216Fontijne, P., 575Forbes, Betty A., 491Forthal, Donald N., 258Fortin, Louise, 83Fourtillan, Jean-Bernard, 618Frankel, Lawrence S., 62Fraser-Smith, Elizabeth B., 563Freydiere, A. M., 144Frongillo, R. F., 666Fuchs, Peter C., 392Funk, Mary L., 301Furman, Phillip A., 191, 507
Gangemi, J. D., 37Garcia-Tornel, Santiago, 706Gardella, A., 331, 401Gavan, Thomas L., 669Gaynon, Michael W., 25George, Karen L., 137George, W. Lance, 657Geratz, J. Dieter, 582Gerding, Dale N., 58, 545, 560Gerlach, E. H., 633, 669Gerv6s, M. Santiago, 458Giamarellou, Helen, 534Gill, Charles J., 327Gill, M. John, 476Gille, Y., 144Girard, A. E., 118Girard, Dennis, 599Giuliano, Ruben A., 783Givan, Katherine F., 455
Glasser, Lynne A., 510Glette, Johan, 354Gnarpe, H'akan, 179Godefroy, Isabelle, 168Godfrey, A. J., 382Goessens, Wil H. F., 575Goldman, Peter, 65Gombert, Myles E., 510Gooch, W. Manford, III, 502Goodman, Larry J., 504Gootz, Thomas D., 591Gordon, Y. Jerold, 522Goto, Sachiko, 98Gotoh, Akira, 754Goueffon, Y., 463Grappel, Sarah F., 694Greenman, Richard L., 16Griffin, Paul E., 33Gropen, Toby I., 522Grossman, Dena M., 690Gruft, Howard, 137Guay, David R., 306Guenthner, Sharon H., 4Guerrant, Richard L., 653Gutterman, Deborah A., 16Guymon, L. F., 767
Halcomb, William W., 20Hall, Dennis, 571Hall, Michael J., 607Haller, Ingo, 125Halstenson, C. E., 128Halstenson, Charles E., 433, 603Hamilton-Miller, J. M. T., 276Hammer, Mark C., 33Hansen, Alfred R., 301Hansen, Chad S., 301Hantz, O., 242Harcus, Jane L., 571Harding, Stuart M., 78, 344Harris, Betty, 162Harris, Cynthia, 560Harrison, Lester I., 301Hashizume, Terutaka, 148Haskell, Suzanne L., 599Hastie, Annette T., 673Hayden, Frederick G., 53Hector, Richard F., 596Heessen, Frans W. A., 123Herbst, John J., 630Hersh, Evan M., 366Hewlett, Erik L., 571Higgins, Michael L., 673Hindler, Janet A., 781Hirata, Takahiro, 148, 348Hoeprich, Paul D., 339Holmes, King K., 390Hooper, David C., 586Hopen, Gunnar, 354Hopfer, R. L., 387Hopfer, Roy L., 366Horaud, Thea, 289Hughes, Carolyn E., 560, 596Humbert, G., 638Hunaiti, Abdelrahim A., 173
Ikeda, Chieko, 221Inaba, Hitoshi, 88Inoue, Hiroshi, 146Inoue, Matsuhisa, 362
i
ANTIMICROB. AGENTS CHEMOTHER.
Isono, Midori, 131Ito, Masahiko, 515
Jackson, David B., 591Jacobs, Michael R., 527Jacoby, Irving, 626Jacyk, William R., 306Jakas, Dalia R., 694James, Philip R., 735Jenkin, H. M., 772Johnson, Elizabeth M., 1Johnson, Jonas, 473Johnson, Randall K., 622Johnson, Steven R., 296Johnston, Ralph W., 205Jones, R. N., 633Jones, Ronald N., 392, 669, 710,
775Jordan, A. B., 37Jorgensen, James H., 283Juliano, R. L., 387Juliano, Rudolph L., 366
Kabir, Iqbal, 643Kamimura, Toshiaki, 98Kanzaki, Masako, 385Kaplan, Raymond L., 504Katz, Ehud, 195Katz, W., 253Keane, W. F., 128Keane, William F., 433Kern, Earl R., 553Kesado, Tadataka, 131Kim, H., 45King, John W., 770Kingsbury, W. D., 373Kirkpatrick, James, 7Klein, Robert S., 292Klinger, Jeffrey D., 279Knaus, Edward E., 476Knight, Paul R., 719Knight, Vernon, 729Kobasa, William D., 683Koeppe, P., 105Kojo, Hitoshi, 98Kolattukudy, Pappachan E., 173Konno, Masatoshi, 754Konopi6iska, Danuta, 134Kosuzume, Hiroshi, 88Koyama, Masaru, 221Kramer, Michael J., 729Kramer, William G., 62Kreeft, John H., 83Kueppers, Friedrich, 673Kunz, Samuel, 311Kuroki, Tohru, 146Kuwahara, Shogo, 98
Kwan, S., 382
Labthavikul, Pornpen, 687Lacroix, Jean-Michel, 662Lambe, Catherine U., 191Lamothe, Francois, 662Larsson, A., 524Lastra, C. Fernandez, 458Lawee, David, 455Lechi, A., 760Lefler, Eli, 450Leguy, F., 638Leive, Loretta, 539Lentino, Joseph R., 778Leroy, A., 638Levi, Joe U., 358Levison, Matthew E., 683
Lewis, John C., 380Lewis, Michael R., 422Li, Edwin L. F., 455Lin, C., 45Lind, I., 767Lipsky, James J., 380Livelli, Thomas J., 247Livermore, David M., 268Lloyd, William J., 607Lode, H., 105Lolekha, Somsak, 273Lopez-Berestein, G., 387Lopez-Berestein, Gabriel, 366Lorian, Victor, 311Lowy, Franklin D., 375Luft, Friedrich C., 513Lukehart, Shelia A., 390Lundback, Annika, 179Lynch, J. E., 118Lyon, James, 473
Maclean, Ian W., 187Mader, Jon T., 139Mageau, Richard P., 205Maimone, F., 499Malewicz, B., 772Mandel, Neil, 109Manian, Albert A., 571Margalith, Eva., 195Marifno, E. L., 458Marino, John, 527Marks, Melvin I., 212Marlowe, Steve, 553Marr, J. Joseph, 292Marsh, Y. Vivienne, 563Martin, Albert R., 626Martinez, Octavio V., 358Maruyama, Tsutomu, 385Maskell, Jeffrey P., 268Matsen, John M., 630Matsui, Hidefumi, 221Matsumoto, Yoshimi, 98Matthews, Thomas R., 563Mattie, H., 263Matzke, G. R., 128Matzke, Gary R., 433, 603McAnally, Thomas P., 422McClatchey, Kenneth D., 491McCormick, Ellen M., 336McCracken, George H., Jr., 2
427, 556McFarland, James W., 226McGory, Robert W., 433McGuirt, Paul V., 507McHugh, Gail L., 586McKeough, M. B., 10McKerlie, M. Louese, 646McLafferty, Martha A., 65Meatherall, Robert C., 306Meddens, M. J. M., 263Mehta, Kapil, 366Mehta, R., 387Mehta, Reeta, 366Mehta, R. J., 373Merigan, Thomas C., 25Merry, Joanne M., 339Meshnick, Steven R., 286Metzger, Linda S., 216Michel, M. F., 575Miller, Heather, 411Miller, Richard L., 191Miller, Wayne H., 191Mills, K., 387Mine, Yasuhiro, 98
Mirabelli, Christopher K., 622Mitsuhashi, Susumu, 362Miyakawa, Isao, 146Mobley, Harry L. T., 157Mochizuki, Hidenori, 88Moellering, R. C., Jr., 331, 401Moellering, Robert C., Jr., 398Molendijk, Lucy, 234Momsen, M., 772Montay, G., 463Moody, Julia A., 545, 560Moretti, A., 666Morgan, S. L., 37Morgant, Catherine, 618Mori, Norimasa, 146Morrison, Joan O., 725Muder, Robert R., 473Muller, G., 281Muramatsu, Masatake, 385Murray, Barbara E., 398Murray, Patrick R., 368Muytjens, Harry L., 123Muzalewski, Feliks, 134Myers, Carolyn M., 579Myers, William F., 690
Nagel, Arthur A., 113Nakagawa, Keiichi, 221Nakatsuru, Naoki, 221Nelson, Donald J., 292Nelson, Erica, 522Nesburn, Anthony B., 522Neu, Harold C., 319, 529, 687Neut, C., 764Nguyen, Khoi B., 455Nicoletti, M., 9Nierste, David M., 513Niles, Ann C., 368Noguchi, Takashi, 221Northrop, Dexter B., 479Novick, William J., Jr., 380
Ober, Robert E., 301Odio, Carla, 427, 556Ogilvie, Richard I., 83Ohmae, Kenichi, 385Ohnishi, Haruo, 88Okafor, Josephine I., 413
9 Olsen, Kurt D., 29Ooka, T., 242Opal, Stephen, 7Otto, Michael J., 566Overall, James C., Jr., 553Overturf, Gary D., 258
Panosian, Claire B., 655Parker, Bruce C., 137Parr, Thomas R., Jr., 747Parrillo, Patricia, 778Passarella, E., 760Pasticci, M. B., 666Patel, Indravadan H., 438Pattison, Fred L. M., 455Pattyn, Stefaan R., 518Pauluzzi, S., 666Pearson, Richard D., 571Penn, Robert L., 770Penner, Brian, 306Pennington, James E., 49Perea, Evelio J., 342Perna, Pasquale, 182Perry, Helen C., 247Peters, Andre C. B., 522
Peterson, Lance R., 58, 545, 560,5%
Pfaller, Michael A., 368Phillips, Lillian, 694Pichoud, C., 242Pickering, Larry K., 62Pirie, Donald K., 226Pitkin, Donald, 694Piziak, Myron V., 7Plotkin, S. A., 417Pohlod, Donald J., 377Pollack, Simeon, 375Pollet, Dirk E., 783Porter, F. D., 157Portnoy, David, 455Potten, Michael R., 1Preblud, S. R., 417Preblud, Stephen R., 327Proctor, E. A., 417Provoost, Abraham P., 497Prusoff, William H., 566Pugsley, Mary P., 494Pushkarskaya, Nina L., 53
Radika, Kesavan, 479Rahaman, M. Mujibur, 643Raimondi, M. G., 760Rector, Tim M., 582Reed, Michael D., 579Retsema J. A., 118Retsema, James A., 113, 226Richardson, Malcolm D., 1Ripa, S., 666Rohlfing, Stephen R., 301Romanowski, Barbara, 455Romaru, Annette, 618Romond, C., 764Ronald, Allan R., 187Roquet, F., 463Rosano, Thomas G., 336Rosen, Barry P., 157Rosenberg, Martin, 622Ross, Janette, 785Rotschafer, John C., 785Rubin, Robert H., 626Ruggiero, Giuseppe, 182Rusconi, Franca, 395Ryder, Neil S., 483
Sabados, Joyce, 646Saino, Yushi, 362Sakata, Yasutaka, 29Sakuma, Takashi, 742Salem, Nanda G., 603Samuel, John, 476Sandberg, Sverre, 354Sanders, Christine C., 494Sanders, W. Eugene, Jr., 494Sanfeliu, Isabel, 706Saravolatz, Louis D., 377Sattler, Fred R., 153Sawada, Takuo, 385Sawai, Tetsuo, 148, 348Saxon, Barbara A., 630Schaberg, Dennis R., 491Scharpe, Simon L., 783Schelkly, W., 118Schentag, Jerome J., 201Schiff, Jill B., 49Schlepushkin, Anatoli N., 53Schnipper, Lowell E., 553Schultz, Robert W., 201Schuppan, Dietrich, 301Schuster, F. L., 109
ii AUTHORINDEX
AUTHOR INDEX iii
Schwab, Bernard, 205Sciavolino, Frank C., 113Scribner, Ronald K., 212Seidl, Gunther, 483Selden, Robert F., 4Seto, Kenji, 385Shafer, W. M., 767Shatzman, Allan R., 622Shaw, James E., 507Sherris, John C., 591Shields, David S., 653Shigeta, Shiro, 515Shikuma, Cecilia, 258Shipley, Patricia L., 653Shlaes, David M., 527Siegel, Scott A., 566Siemsen, A. W., 438Silver, Simon, 157Sirinavin, Sayomporn, 273Slaney, Leslie A., 187Smith, C. W., 37Smith, Gaylord, 286Smith, Margaret C. M., 446Smith, Raymond P., 33, 488Sobel, J. D., 281Solberg, Claus O., 354Solliday, JoAnne, 532Somerville, Peter J., 83Sommers, De Klerk, 344Sommers, H. M., 633Sommers, Herbert M., 669Southern, J. A., 253Sparling, P. F., 767Spencer, G. R., 638Spruance, S. L., 10Spruance, Spotswood L., 553St. Clair, Marty H., 191Stachowski, Michael, 778Starr, S. E., 417Steigbigel, Neal H., 375Stern, Robert C., 579
Stevens, David A., 450Storrs, Bruce, 502Strikas, Raymond, 778Stutman, Harris R., 212Sugerman, A. Arthur, 93Sugihara, J. G., 438Sun, Chong-Son, 729Sutphen, Nancy, 33Sutton, J. P., 37Swabb, Edward A., 93Swartz, Mark D., 586Swartz, Morton N., 586Szoka, Francis, 655
Tagari, Gioula, 534Takafuji, Ernest, 7Takahashi, Toshio, 385Tannenbaum, Charles S., 673Tao, Pei-Zhen, 524Taylor, Dean P., 622Telesetsky, Stephanie, 539Terakado, Nobuyuki, 385TeStrake, Diane, 413Thearle, Patricia, 473Thomas, Marion L., 29, 427,Thompson, J., 263Thompson, Robert L., 4Thornsberry, C., 633Thornsberry, Clyde, 392, 710Threlkeld, Norma, 556Ti, Teow-Yee, 83Tidwell, Richard R., 582Tiemens, Karen M., 653Tigaud, S., 144Tocci, Michael J., 247Tofte, Robert W., 532, 785Tolkoff-Rubin, Nina E., 626Tramont, Edmund, 7Trenholme, Gordon M., 504Trepo, C., 242Trevisan, Alejandro R., 659
Troke, Peter F., 483Trousdale, Melvin D., 522Tuazon, Carmelita U., 411Tung, Charlotte, 586Tyrrell, D. Lorne, 476
Ubukata, Kimiko, 754Ueno, Kazue, 131Utili, Riccardo, 182
Vaara, M., 701Valenta, J., 373Van Caekenberghe, Dirk L., 518Van Etta, Linda L., 58van Furth, R., 263Van Leeuwen, Willem B., 497van Raffe, M., 575Van Schalkwijk, Wim P., 497Van Wyk, Marieta, 344Vaxelaire, Juliane, 311Velo, G. P., 760Verbist, Ludo, 141, 783Verhaegen, Jan, 141Verpooten, Gert A., 783
556 Viljanen, P., 701Vincent, P., 144Visscher, David W., 513Visudhipan, Pongsakdi, 273Vitvitski, L., 242Vosbeck, Klaus, 735
Wagenvoort, Johan H. T., 497Walker, David H., 582Walker, Marion L., 502Walker, Naomi A., 513Walker, Richard I., 71Warnock, David W., 1Watanabe, Kunitomo, 131Weinbaum, George, 673Weinfeld, R. E., 438Weiss, Emilio, 71
Welage, Lynda S., 201Welch, David F., 212Wennersten, Christine, 398Wenzel, Richard P., 4Westmacott, Donald, 607Wexler, Hannah, 162Wiebe, Leonard I., 476Williams, J. David, 268Williams, Peter E. O., 78, 344Williamson, Peter J., 1Wilson, Katharine J., 139Wilson, Mary E., 626Wilson, Samuel Z., 729Wise, R., 612Wisseman, Charles L., Jr., 690Wolfson, John S., 586Wong, E. G. C., 438Woodbury, Charles, 7Woods, D. R., 253Wright, Charlotte A., 408Wright, Donald N., 165Wu, David H., 488Wyde, Philip R., 729Wyler, David J., 655
Yamaguchi, Akihito, 148, 348Yamashita, Naoko, 754Yamashita, Toyoko S., 579Yangco, Bienvenido G., 413Yano, Kuniichiro, 221Yeung, Tin-Chuen, 65Yoshinaga, Koji, 221Yu, Victor L., 473
Zaffaroni, Giuseppe, 395Zak, Oto, 311Zimmermann, Willy, 735Zissis, Nicholas P., 534Zorz6pulos, Jorge, 659Zuromskis, Peter, 626Zweig, Richard M., 16
VOL. 25, 1984
SUBJECT INDEX
VOLUME 25
AC-1370mechanism of action, 88phagocyte functions, 88
Acanthamoeba spp.phenothiazone compounds, 109
Acridine orangeK. pneumoniae R plasmid deletion, 659
Acyclic nucleosides9-(1,3-dihydroxy-2-propoxymethyl)
guanine, 563Acyclovir
antiviral-activity potentiationpolyene macrolides, 772
efficacy, 10herpes simplex virus, 10DNA fragment synthesis, 507patient-initiated treatment, 553
penetration, 10synergy with interferon, 515topical therapy, 10varicella-zoster virus, 515
Adenine arabinosidesynergy with interferon, 515varicella-zoster virus, 515
Aerobic bacteriaerythromycin, 529RU 28965, 529
Amikacincombinations
ceftazidime, 725ceftizoxime, 725ceftriaxone, 725cystic fibrosis, 279P. aeruginosa, 279P. cepacia, 279
Enterobacteriaceae, 725nephrotoxicity, 168neutropenic-site rabbit model, 545P. aeruginosa, 545tubular reabsorption, 168
Aminoglycosidescombinations
teichomycin, 411vancomycin, 411
enterococci, 411extraction from renal cortical tissue, 783modification by enzymes
S. aureus, 754S. epidermidis, 754
nephrotoxicity, 1682"-O-nucleotidyltransferase activity, 234P. aeruginosa, 488, 534rat tissueenzyme immunoassays, 497
resistance, 234staphylococci, 411synergy with 13-lactams, 534tubular reabsorption, 168
Amoxicillincombined with clavulanic acid, 276urinary tract infections, 276, 626
Amphotericin Bantifungal activity, 387Aspergillus spp., 560C. albicans infection, 366combinations
antifungal agents, 560rifampin, 560
leishmaniasis, 655liposome encapsulated, 366, 387, 655prophylaxis, 366
Ampicillincombinationsgentamicin, 408
comparative efficacypivmecillinam, 643
S. faecalis endocarditis, 408shigellosis, 643
Anaerobic bacteriaapalcillin, 162cefoxitin, 764cefpiramide, 162ciprofloxacin, 342clindamycin, 764erythromycin, 529metronidazole, 764RU 28965, 529
Animal viruseshalothane, 719replication, 719
Antifungal agentsAspergillus spp., 560combinations
amphotericin B, 560rifampin, 560
Antifungal azolesBay 1 9139, 339Bay n 7133, 339
Antineoplastic agentsscreening
E. coli genetically modified strain, 622Antiviral compounds
varicella-zoster virus susceptibility, 417Apalcillin
anaerobes, 162comparative activity, 162
carbenicillin, 669piperacillin, 669
pharmacokineticscompared with piperacillin, 105
1-,-D-Arabinofuranosyl-E-5-(2-bromovin-yl)uracil
varicella-zoster virus, 742Arsenate
E. coli R factors, 157Aspergillus spp.
amphotericin B, 560antifungal agents, 560rifampin, 560
Azlocillincomparative efficacy, 49neutropenic-site rabbit model, 545P. aeruginosa
drug combinations, 545pneumonia, 49
pharmacokineticscystic fibrosis, 630
Aztreonamactivity
alone, 212in combination, 212
biliary tract disease, 358combinations
amikacin, 279cystic fibrosis, 279gram-negative bacilli, 2833-lactams, 283
multiple resistance, 283P. aeruginosa, 279P. cepacia, 279
comparative efficacy, 49excretion, 358
immunology, 93P. aeruginosa pneumonia, 49pediatric patients, 212syphilis, 390
Bacillus megateriumcopper toxicity, 650siderophores, 650
Bacitracincoagulase-negative staphylococci, 502S. aureus nasal carriers, 422
Bacterial infectionscefmenoxime, 510
BacteriocinsB. fragilis, 253
Bacteroides fragilisbacteriocins, 253cephalosporins7a-methoxy, 1317p-methoxyiminoacetamido, 131
clavulanic acid, 662P-lactams, 662synergy with gentamicin
clindamycin, 71metronidazole, 71penicillin, 71
Bacteroides melaninogenicussynergy with gentamicin
clindamycin, 71metronidazole, 71penicillin, 71
Basidiobolus spp.susceptibility, 413
Bay 1 9139antifungal activity, 339
Bay n 7133antifungal activity, 339high-pressure liquid chromatography,
596Bay o 9867
see ciprofloxacinBenzylpenicillinprobenecid interaction, 676
Biliary tract diseaseaztreonam excretion, 358
Biophotometric methodsS. aureus intraphagocytic activity, 735
Bordetella pertussisdegraded strains, 537resistance, 537
Bromovinyl deoxyuridinesynergy with interferon, 515varicella-zoster virus, 515
(E)-5-(2-Bromovinyl)-2'-deoxyuridineherpes simplex virus polypeptide syn-
thesis, 566BW7S9UDNA polymerases
cellular a, 191herpes simplex virus induced, 191
triphosphate, 191
Campylobacter fetus subsp. jejunimetronidazole, 145niridazole, 145
Campylobacter spp.ciprofloxacin, 504
Candida albicansamphotericin B, 366
iv
SUBJECT INDEX v
clotrimazole, 450econazole, 450growth, 483ketoconazole, 281, 450miconazole, 450naftifine, 483neutropenic mice, 366sterol biosynthesis, 483susceptibilitygrowth phase, 316ketoconazole, 316miconazole, 316
tioconazole, 450vaginitis, 281
Candida spp.peptide transport, 373polyoxin, 373
Carbapenem derivativesSF2103A, 348
Carbenicillincomparative activity
apalcillin, 669piperacillin, 669
hemostasis, 153Cardiopulmonary bypass surgery
ceftriaxone levels, 37Cefamandole
cross-resistancemethicillin, 666
E. colikilling, 182phagocytosis, 182
Cefazolinurinary excretion
furosemide, 618piretanide, 618water loading, 618
Cefmenoximeserious bacterial infections, 510
Cefoperazonepenetration into surgical-wound drain-
age, 473Ceforanide
S. aureus endocarditis, 16Cefotaxime
kineticseffects of protein binding, 58
susceptibility, 377Cefotiam
comparative efficacycephalothin, 778
dihydrochlorideplacental transfer, 147
skin infections, 778soft tissue infections, 778
Cefoxitinanaerobic bacteria, 764comparative activity
clindamycin, 764metronidazole, 764
neutropenic-site rabbit model, 545P. aeruginosa, 545
Cefpiramideanaerobes, 162comparative activity, 162pharmacokineticshumans, 221
Cefsulodincystic fibrosis, 4P. aeruginosa mutants, 382pharmacokinetics
cystic fibrosis, 579single dose, 579
Ceftazidimecombinations
amikacin, 725clindamycin, 657gentamicin, 725
distribution in ascitic fluid, 760Enterobacteriaceae, 725H. influenzae, 29meningitis
efficacy, 29pharmacokinetics, 29
nephrotoxicity in rats, 513P. aeruginosa mutants, 382pharmacokinetics
decreased renal function, 785meningitis, 29normal subjects, 638renal insufficiency, 201uremic subjects, 638
Pseudomonas spp., 395urinary tract infections, 395
Ceftizoximecombinations
amikacin, 725gentamicin, 725, 770
Enterobacteriaceae, 725high-pressure liquid chromatography,
336meningitis, 258neutropenic-site rabbit model, 545P. aeruginosa, 545, 770uremic patients, 336
Ceftriaxoneamikacin, 725combinations
gentamicin, 725Enterobacteriaceae, 725H. influenzae, 29kinetic disposition
renal failure patients, 83levels in blood and tissuecardiopulmonary bypass surgery, 37
meningitisefficacy, 29, 40
pharmacokineticsmeningitis, 29renal impairment, 438
Cefuroxime1-acetoxyethyl ester, 78axetil
pharmacokinetics, 344meningitis, 273
CephalosporinasesP. maltophilia, 362
Cephalosporinsaminothiazolyl a-methoxyimino, 710B. fragilis, 131cross-resistance
cefamandole, 666methicillin, 666
expanded spectrumSK&F 88070, 694
HR810, 7107a-methoxy, 1317p-methoxyiminoacetamido, 131resistance
Citrobacter spp., 591Cephalothincomparative efficacy
cefotiam, 778Enterobacteriaceae resistance, 725skin infections, 778soft tissue infections, 778
CephemsFK 027, 98
ChancroidH. ducreyi, 187tetracycline resistance, 187
Chlamydia trachomatiscinoxacin, 123ciprofloxacin, 123nalidixic acid, 123norfloxacin, 123pipemidic acid, 123
Chloramphenicolantagonism of 3-lactams, 405comparative activity, 327detection, 205enzyme-linked immunoassay, 205K. pneumoniae, 405quantitation, 205Salmonella spp., 327
Chlorpromazinehydrochloride
pathogenic amoebae, 109L. donovani, 571
Cinoxacinantibacterial activity, 633cross-resistance
DJ6783, 775enoxacin, 775nalidixic acid, 775norfloxacin, 775oxolinic acid, 775
C. trachomatis, 123resistant-population selection, 775
Ciprofloxacinanaerobic bacteria, 342antibacterial activity, 633Campylobacter spp., 504comparative activity, 319, 331, 518C. trachomatis, 123enteric pathogens, 504inoculum effect, 342medium effect, 342pH effect, 342
Citrobacter spp.cephalosporin resistance, 591
Clavulanic acidcombined with amoxicillin
urinary tract infections, 276combined with ticarcillin, 392,-lactam activity, 662
Clindamycinanaerobic bacteria, 764combined with ceftazidime
antibacterial activity, 657comparative activity
cefoxitin, 764synergyBacteroides spp., 71gentamicin, 71
ClotrimazoleC. albicans, 450
Cloxacillinstaphylococcal endocarditis, 311
Common coldzinc gluconate, 20
Conidiobolus spp.susceptibility, 413
Contact-blocking virus inhibitorsize, 646stability, 646
CopperB. megaterium, 560toxicity
VOL. 25, 1984
ANTIMICROB. AGENTS CHEMOTHER.
siderophores, 560Coumermycin
antibacterial activity, 687Cystic fibrosis
amikacin, 279azlocillin pharmacokinetics, 630aztreonam, 279cefsulodin
pharmacokinetics, 579sodium, 4
P. aeruginosa, 279P. cepacia, 279piperacillin, 279ticarcillin, 279
Cytomegalovirusa-interferon, 252'-nor-2'-deoxyguanosine, 247retinitis, 25
Desferrioxamineurinary tract isolates, 375
cis-Diammineplatinum[II]-polyglutamicacid
T. congolense, 286Dibekacin
nephrotoxicity, 168tubular reabsorption, 168
9-(1,3-Dihydroxy-2-propoxymethyl)guanine
herpes simplex virus, 563,-interferon, 563
DJ6783cross-resistance
cinoxacin, 775enoxacin, 775nalidixic acid, 775norfloxacin, 775oxolinic acid, 775
resistant-population selection, 775DNA gyrase inhibitors
E. coli plasmid elimination, 586DNA polymerasesBW759U triphosphate, 191cellular a, 191hepatitis virus, 242herpes simplex virus induced, 191
Doxycyclinepolymorphonuclear leukocytes, 354
EconazoleC. albicans, 450
Endocarditisampicillin, 408ceforanide, 16cloxacillin, 311drug abusers, 16gentamicin, 408granulocytes, 263mezlocillin, 408S. aureus, 16S. faecalis, 408S. sanguis, 263staphylococcal, 311
Enoxacincross-resistance
cinoxacin, 775DJ6783, 775nalidixic acid, 775norfloxacin, 775oxolinic acid, 775
resistant-population selection, 775
Enteric pathogensciprofloxacin, 504
Enterobacter aerogenesendocarditis
gentamicin, 683mezlocillin, 683ticarcillin, 683
EnterobacteriaP-lactamases, 268
Enterobacteriaceaeamikacin, 725ceftazidime, 725ceftizoxime, 725ceftriaxone, 725cephalothin resistant, 725gentamicin, 725
Enterococciaminoglycosides, 411ribosomal resistance, 398rifampin, 411streptomycin, 398susceptibility, 532teichomycin, 411vancomycin, 411
Enzyme immunoassaysaminoglycosides
rat tissue, 497Enzyme-linked immunoassays
competitivechloramphenicol, 205
Enzymesaminoglycoside modification, 754S. aureus, 754S. epidermidis, 754
Erysipelasswine
E. rhusiopathiae resistance, 385Erysipelothrix rhusiopathiae
chronic swine erysipelas, 385resistance, 385
Erythromycinaerobic bacteria, 529anaerobic bacteria, 529comparative activity, 529methylmalonyl-coenzyme A source, 173synthesis from S. erythreus, 173
Escherichia colicefamandole, 182DNA gyrase inhibitors, 586DNA repair mutants, 65genetically modified strain
antineoplastic-agent screening, 622gentamicin, 182killing, 182meningitis
mezlocillin pharmacokinetics, 427metronidazole, 65novobiocin, 586outer membrane permeability, 539phagocytosis, 182plasmid elimination, 586pMG110, 586R factors
arsenate, 157homology, 157
tetracyclines, 539tetracycline transport, 446
ExopolysaccharidesP. aeruginosa
binding, 673
FK 027antibacterial properties, 98
Fludalaninepentizidone combinationcomparative activity, 612
Flumequinefluorometric assays, 301high-pressure liquid chromatography,
301microbiological assays, 301
Fluorinated piperazinyl-substituted quino-line derivatives
comparative activity, 518Fluorometric assays
flumequine, 301Furosemide
cefazolin excretion in urine, 618
Gentamicincoagulase-negative staphylococci, 502combinations
ampicillin, 408ceftazidime, 725ceftizoxime, 725, 770ceftriaxone, 725mezlocillin, 408
E. colikilling, 182phagocytosis, 182
elimination rate, 128clearance, 128
Enterobacteriaceae, 725hemodialysis, 128nephrotoxicity, 168P. aeruginosa, 770synergy
B. fragilis, 71B. melaninogenicus, 71clindamycin, 71metronidazole, 71penicillin, 71
tubular reabsorption, 168Gonorrhea
rosoxacin, 455Gram-negative bacteria
aztreonam, 283,B-lactams, 283multiple resistance, 283polymyxin B nonapeptide, 701
GranulocytesS. sanguis endocarditis, 263stimulationimipenem, 179MK 0791, 179
Haemophilus ducreyichancroid treatment, 1871-lactamase plasmid, 296resistance
plasmid mediated, 187tetracycline, 187
Haemophilus influenzaemultiply resistant
susceptibility, 706type b
ceftazidime, 29ceftriaxone, 29chloramphenicol resistant, 29imipenem, 293-lactams, 747mechanisms of resistance, 747meningitis, 29
Halothaneanimal virus replication, 719
vi SUBJECT INDEX
SUBJECT INDEX vii
Heavy-metal saltssusceptibilityM. avium, 137M. intracellulare, 137M. scrofulaceum, 137
Hemodialysisgentamicin
clearance, 128elimination rate, 128
tobramycinclearance, 128elimination rate, 128
Hemostasiscarbenicillin, 153mezlocillin, 153placebo, 153
Hepatitis virusDNA polymerases, 242human, 242woodchuck, 242
Herpes labialisacyclovir, 553patient-initiated treatment, 553
Herpes simplex virusacyclovirDNA fragment synthesis, 507efficacy, 10penetration, 10topical therapy, 10
(E)-5-(2-bromovinyl)-Z'-deoxyuridine,566
BW759U triphosphate, 1919-(1,3-dihydroxy-2-propoxymethyl)
guanine, 563DNA polymerase induction, 191p-interferon, 563(E)-5-(2-iodovinyl)-2'-deoxyuridine up-
take, 476lithium
cell cultures, 522latent-infection reactivation in rab-
bits, 5222'-nor-2'-deoxyguanosine, 238orofacial infections in mice, 238polypeptide synthesis, 566SK&F 21681, 195thymidine kinaseguanosine analogs, 524
High-pressure liquid chromatographyBay n 7133, 596ceftizoxime, 336flumequine, 301Sch 28191 levels, 45
HR810evaluation, 710
Hypoprothrombinemia1-methyl-5-thiotetrazole, 380moxalactam, 380
ImidazolesC. albicans, 450clotrimazole, 450econazole, 450ketocanazole, 450miconazole, 450tioconazole, 450
Imipenembioactivitymedium, 781temperature, 781time, 781
granulocyte function stimulation, 179
H. influenzae, 29imipenem resistance, 491meningitis
efficacy, 29pharmacokinetics, 29
methicillin resistanceS. aureus, 491
P. vulgaris P-lactamase, 149subinhibitory concentrations, 491
Influenza virusinhibition
interferon, 53ribavirin, 53rimantadine hydrochloride, 53
Inosine analogsLeishmania spp., 292Trypanosoma spp., 292
Interferonaerosolized, 729clearance, 729cytomegalovirus retinitis, 259-(1,3-dihydroxy-2-propoxymethyl)
guanine, 563herpes simplex virus, 563human leukocyte, 515influenza virus inhibition, 53pulmonary deposition, 729synergy
acyclovir, 515adenine arabinoside, 515bromovinyl deoxyuridine, 515phosphonoformic acid, 515
Intraphagocytic activitybiophotometric method, 735S. aureus, 735
(E)-5-(2-Iodovinyl)-2 '-deoxyuridineherpes simplex virus, 476uptake, 476
Kanamycinacetyltransferaseenzymatic modification, 479resistance, 479VmaxlKm ratio, 479
KetoconazoleC. albicansgrowth phase, 316inhibition, 450killing, 450susceptibility, 316vaginitis, 281
pharmacokineticsinfluence of food, 1
Klebsiella pneumoniaechloramphenicol, 405P-lactams, 405R plasmids
acridine orange, 659deletions, 659
3-Lactamasesenterobacteria, 268H. ducreyi, 296inactivation, 348mezlocillin-resistant S. aureus
cell bound, 125extracellular, 125
N. gonorrhoeae, 296P. aeruginosa mutants, 382PSE-2, 268P. vulgaris
imipenem, 149
SF2103A, 348,-Lactamsantagonism by chloramphenicol, 405B. fragilis
clavulanic acid, 662combinations
aztreonam, 283gram-negative bacilli, 283multiple resistance, 283
H. influenzae type bmechanism of resistance, 747
K. pneumoniae, 405P. aeruginosa, 488, 534synergy with aminoglycosides, 534temocillin combinations, 142
Lankacidin group antibioticsside chain modifications, 226
Leishmania donovanichlorpromazine, 571
Leishmaniasisamphotericin B, 655
Leishmania spp.inosine analogs, 292
Listeria monocytogenesmeningitis
mezlocillin pharmacokinetics, 427Lithium
herpes simplex viruscell cultures, 522latent-infection reactivation in rab-
bits, 522
Meningitisceftazidime, 29ceftizoxime, 258ceftriaxone, 29, 40cefuroxime, 273E. coli, 427imipenem, 29L. monocytogenes, 427mezlocillin pharmacokinetics, 427traditional therapy, 40
Methicillincross-resistance
cefamandole, 666cephalosporins, 666
resistanceimipenem, 491S. aureqs, 491
Methylmalonyl-coenzyme Aerythromycin synthesis, 173S. erythreus, 173
1-Methyl-5-thiotetrazolehypoprothrombinemia, 380
Metronidazoleanaerobic bacteria, 764C. fetus subsp. jejuni, 145comparative activity
cefoxitin, 764E. coli DNA repair mutants, 65pharmacokinetics
peritoneal dialysis patients, 306synergyBacteroides spp., 71gentamicin, 71
Mezlocillincombinations
gentamicin, 408, 683E. aerogenes endq~zarditis, 683E. coli, 427hemostasis, 153
VOL. 25, 1984
ANTIMICROB. AGENTS CHEMOTHER.
L. monocytogenes, 427pharmacokinetics
meningitis, 427newborn infants, 556pediatric oncology patients, 62
S. aureus resistance,-lactamase, 125
S. faecalis endocarditis, 408Miconazole
C. albicansgrowth phase, 316inhibition, 450killing, 450susceptibility, 316
Microbiological assaysflumequine, 301
Minocyclinepolymorphonuclear leukocytes, 354
MK 0791granulocyte function stimulation, 179
Moxalactamhypoprothrombinemia, 380pharmacokinetics
elderly subjects, 33Mycobacterium avium
susceptibilityheavy-metal salts, 137oxyanions, 137
Mycobacterium intracellularesuspectibilityheavy-metal salts, 137oxyanions, 137
Mycobacterium scrofulaceumsusceptibility
heavy-metal salts, 137oxyanions, 137
Naegleria fowleriphenothiazone compounds, 109
NaftifineC. albicans, 483
Nalidixic acidantibacterial activity, 633cross-resistance
cinoxacin, 775DJ6783, 775enoxacin, 775norfloxacin, 775oxolinic acid, 775
C. trachomatis, 123resistant-population selection, 775
Neisseria gonorrhoeaeenvelope mutations
antibiotic susceptibility, 767env-10, 767pyocin resistance, 767
,B-lactamase plasmid, 2%probenecid, 676resistance trends, 7
Neisseria meningitidisnasopharyngeal carriers, 494Sch 29,482, 494
Nephrotoxicityaminoglycosides, 168tubular reabsorption, 168
Netilmicinnephrotoxicity, 168tubular reabsorption, 168
NiridazoleC. fetus subsp. jejuni, 145
Nocardia asteroidessusceptibility, 165
Nocardicin Asynergy
L-norvalyl-L-1-aminoethylphosphonicacid, 105
2'-Nor-2'-deoxyguanosinecytomegalovirus, 247herpes simplex virus, 238
Norfloxacinantibacterial activity, 633cross-resistance
cinoxacin, 775DJ6783, 775enoxacin, 775nalidixic acid, 775oxolinic acid, 775
C. trachomatis, 123resistant-population selection, 775
L-Norvalyl-L-1-aminoethylphosphonicacid
synergynocardicin A, 607
NovobiocinE. coli plasmid elimination, 586
2"-O-Nucleotidyltransferaseactivity-aminoglycoside resistance rela-
tion, 234
Oleandomycinderivatives
biological activity, 113, 118synthesis, 113
Osteomyelitisvancomycin
concentrations in rabbit serum, 140Oxacillin
coagulase-negative staphylococci, 502Oxolinic acid
antibacterial activity, 633cross-resistance
cinoxacin, 775DJ6783, 775enoxacin, 775nalidixic acid, 775norfloxacin, 775
resistant-population selection, 775Oxyanions
susceptibilityM. avium, 137M. intracellulare, 137M. scrofulaceum, 137
Oxytetracyclinepolymorphonuclear leukocytes, 354
Pediatric patientsaztreonam activity, 212
Pefloxacin mesylateabsorption, 463distribution, 463elimination, 463metabolic fate, 463
PenicillinsynergyBacteroides spp., 71gentamicin, 71
Pentizidonefludalanine combination
comparative activity, 612Pharmacokinetics
apalcillin, 105azlocillin, 607cefpiramide, 221cefsulodin, 579
ceftazidimedecreased renal function, 785H. influenzae meningitis, 29normal subjects, 638renal insufficiency, 201uremic subjects, 638
ceftriaxoneH. influenzae meningitis, 29renal impairment, 438
cefuroxime axetil, 344imipenem, 29ketoconazole, 1metronidazole, 306mezlocillin
meningitis, 427newborn infants, 556pediatric oncology patients, 62
moxalactam, 33piperacillin, 105sultamicillin, 599vancomycin
peritoneal dialysis, 603renal insufficiency, 433
Phenothiazone Fompoundschlorpromazine hydrochloride, 109inhibition of pathogenic amoebae, 109trifluoperazine dihydrochloride, 109
Phosphomycinpleural effusion patients, 458
Phosphonoformic acidsynergy with interferon, 515varicella-zoster virus, 515
Pipemidic acidC. trachomatis, 123
Piperacillincombinations
amikacin, 279cystic fibrosis, 279P. aeruginosa, 279P. cepacia, 279
comparative activityapalcillin, 669carbenicillin, 669
comparative efficacy, 49P. aeruginosa
mutants, 382pneumonia, 49
pharmacokineticscompared with apalcillin, 105
susceptibility, 377Piretanide
cefazoline excretion in humans, 618Pivmecillinamcomparative efficacy
ampicillin, 643shigellosis, 643
Placebohemostasis, 153
PlasmidsDNA gyrase inhibitors, 586E. coli(pMG110), 586novobiocin, 586resistance
acridine orange, 659deletions, 659host range, 289K. pneumoniae, 659streptococcal macrolide, 289
S. wien epidemic history, 499Pleural effusionphosphomycin, 458
Pneumoniaazlocillin, 49
viii SUBJECT INDEX
SUBJECT INDEX ixVOL. 25, 1984
aztreonam, 49P. aeruginosa, 49piperacillin, 49ticarcillin, 49tobramycin, 49
Polyene macrolidesacyclovir activity, 772
Polymorphonuclear leukocytesdoxycycline, 354minocycline, 354oxytetracycline, 354
Polymyxin B nonapeptidegram-negative bacteria, 701
Polyoxinanti-Candida activity, 373peptide transport, 373
Probenecidbenzylpenicillin interaction, 676N. gonorrhoeae, 676
Protease inhibitorsamidine type, 582R. rickettsii, 582
Protein bindingcefotaxime kinetics, 58
Proteus vulgaris1-lactamaseimipenem, 149
Pseudomonas aeruginosaamikacin, 279, 545aminoglycosides, 488, 534azlocillin, 49, 545aztreonam, 49, 279cefoxitin, 545cefsulodin, 382ceftazidime, 382ceftizoxime, 545, 770cystic fibrosis, 279exopolysaccharide
binding, 673gentamicin, 770P-lactamase, 382P-lactams, 488, 534mutants, 382neutropenic-site rabbit model, 545piperacillin, 49, 279, 382pneumonia, 49ticarcillin, 49, 279tobramycin, 49
Pseudomonas cepaciaamikacin, 279aztreonam, 279cystic fibrosis, 279piperacillin, 279ticarcillin, 279
Pseudomonas maltophiliacephalosporinase, 362
Pseudomonas spp.ceftazidime, 395urinary tract infections, 395
PyocinsN. gonorrhoeae resistance, 767
Quinolone carboxylic acid compoundsciprofloxacin, 319, 331
Renal enzyme inhibitorsMK 0791, 179
Renal insufficiencypharmacokinetics
ceftazidime, 201ceftriaxone, 438vancomycin, 433
ResistanceN. gonorrhoeae, 7
Retinitiscytomegalovirus, 25a-interferon, 25
R factorsE. coli
arsenate, 157homology, 157
Ribavirininfluenza virus inhibition, 53
Rickettsia rickettsiicell injury, 582protease inhibitors, 582
RifampinAspergillus spp., 560combinations
amphotericin B, 560antifungal agents, 560teichomycin, 411vancomycin, 411
enterococci, 411S. aureus nasal carriers, 422staphylococci, 411
Rimantadine hydrochlorideinfluenza virus inhibition, 53
Rochalimaea quintanasusceptibility patterns, 690trench fever, 690
Rosoxacingonorrhea, 455
RU 28965aerobic bacteria, 529anaerobic bacteria, 529comparative activity, 529
Salmonella spp.chloramphenicol, 327
Salmonella wienepidemic history, 499plasmid stability, 499
Sch 28191high-pressure liquid chromatography,
45levels in biological fluids, 45
Sch 29,482N. meningitidis nasopharyngeal carri-
ers, 494SF2103A
3-lactamase inactivation, 348Shigella flexneri
sulfamethoxazole-trimethoprim resist-ance, 653
Shigellosisampicillin, 643pivmecillinam, 643
SiderophoresB. megaterium, 560copper toxicity enhancement, 560
SK&F 21681herpes simplex virus, 191
SK&F 88070antimicrobial activity, 694
Skin infectionscefotiam, 778cephalothin, 778
SM-1652see cefpiramide
Soft tissue infectionscefotiam, 778cephalothin, 778
Sparsomycinnontoxic analogshydrophobic sulfoxide substituent,
443puromycin, 443
Staphylococciaminoglycosides, 411cloxacillin, 311coagulase negative
bacitracin, 502gentamicin, 502oxacillin, 502streptomycin, 502vancomycin, 502
endocarditis, 311rifampin, 411teichomycin, 411vancomycin, 411
Staphylococcus aureusaminoglycoside-modifying enzyme, 754biophotometric method, 735ceforanide, 16endocarditis, 16intraphagocytic activity, 735mezlocillin resistance
P-lactamase, 125nasal carriers
bacitracin, 422rifampin, 422
resistanceimipenem, 491methicillin, 491
tolerance detection, 571Staphylococcus epidermidis
aminoglycoside-modifying enzyme, 754Streptococci
resistance plasmids, 289Streptococcus faecalis
ampicillin, 408gentamicin, 408endocarditis, 408mezlocillin, 408
Streptococcus sanguisendocarditis, 263granulocytes, 263vancomycin resistance, 527
Streptomyces erythreuserythromycin synthesis, 173methylmalonyl-coenzyme A, 173
Streptomyces fradiaecarbon incorporation
tylactone, 216Streptomycin
coagulase-negative staphylococci, 502enterococci, 398ribosomal resistance, 398
Sulfamethoxazolecombined with trimethoprim, 653
Sulfamethoxazole-trimethoprimS. flexneri resistance, 653
Sultamicillinpharmacokinetics, 599
Surgical woundscefoperazone penetration, 473
Syphilisaztreonam, 390
Teichomycincombinations
aminoglycosides, 411rifampin, 411
enterococci, 411staphylococci, 411
ANTIMICROB. AGENTS CHEMOTHER.
Temocillincombined with other 3-lactams, 142
Tetracyclineschancroid treatment, 187doxycycline, 354E. coli outer membrane permeability,
539H. ducreyi resistance, 187hydrophobicity, 539minocycline, 354oxytetracycline, 354polymorphonuclear leukocytes, 354transport into E. coli, 446
Ticarcillincombinations
amikacin, 279clavulanic acid, 392cystic fibrosis, 279gentamicin, 683P. aeruginosa, 279P. cepacia, 279
comparative efficacy, 49E. aerogenes endocarditis, 683P. aeruginosa pneumonia, 49
TioconazoleC. albicans, 450
Tobramycinclearance, 128comparative efficacy, 49elimination rate, 128hemodialysis, 128P. aeruginosa pneumonia, 49susceptibility, 377
Trench feverR. quintana
susceptibility patterns, 690Trifluoperazine dihydrochloride
pathogenic amoebae, 109Trimethoprimcombined with sulfamethoxazole, 653
Trypanosoma congolensecis-diammineplatinum[II]-poly-glutam-
ic acid, 286Trypanosoma spp.
inosine analogs, 292Tuftsin
analogs, 134antibacterial properties, 134
Tylactonecarbon incorporationamino acid derived, 216S. fradiae, 216
U-63196Ecomparative activity, 401
Urinary tract infectionsamoxicillin, 626amoxicillin-clavulanic acid, 276ceftazidime, 395desferrioxamine, 375Pseudomonas spp., 395
VaginitisC. albicans, 281ketoconazole, 281
Vancomycincoagulase-negative staphylococci, 502combinations
aminoglycosides, 411rifampin, 411
enterococci, 411osteomyelitis
concentrations in rabbit serum, 140pharmacokinetics
peritoneal dialysis, 603renal insufficiency, 433
S. sanguis resistance, 527staphylococci, 411
Varicella-zoster virusacyclovir, 515adenine arabinoside, 5151-0-D-arabinofuranosyl-E-5-(2-bromo-
vinyl)uracil, 742bromovinyl deoxyuridine, 515interferon, 515phosphonoformic acid, 515susceptibility, 417
WIN 49375susceptibility, 377
Zinc gluconatecommon cold, 20double-blind study, 20
x SUBJECT INDEX
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