Abbrevat ions
Autoant ibodies
Guidelines for diagnostic evaluation of autoimmune diseases
AN
A
ds-D
NA
ss-D
NA
His
tone
Nuc
leos
ome
ENA
RNP
Sm SS-A
SS-B
Scl-7
0
Jo-1
Cent
rom
ere
Ribo
som
al P
PM-S
cl
PCN
A
RF Waa
ler-
Rose
CCP
AN
CA
MPO
PR-3
Lact
ofer
rin
BP1
GS-
AN
A
GB
M
TBM
Card
iolip
in
ß-2
GP1
LA anti-
C1q
AM
A
SMA
LKM
SLA
ASC
A
Endo
thel
ium
Retic
ulin
APC
A
Stria
ted
mus
cle
Card
iac
mus
cle
Coom
bs
Thro
mbo
cyte
TPO
HTG
TSH
rece
ptor
ICA
Adr
enal
(gla
nd)
Ster
oid
cell
Sper
m
EMA
-IgA
EMA
-IgG
tTG
-IgA
tTG
-IgG
Glia
din
IgA
Glia
din
IgG
Pem
phig
us (I
C)
BM
Z
ACh
R
Para
thyr
oid
Systemic autoimmune diseases
Active SLE • • • •Inactive SLE • • •Discoid LE Subacute cutaneous LE
Drug-induced lupus • •Neonatal LE • •MCTD / Sharp syndrome •PSS •CREST syndrome •Raynaud syndrome
PM / DM •PM / Scl overlap •UCTD
RA adult • • •Felty syndrome • • • •JCA
Sjögren syndrome •Polyarthritis nodosa
Primary APS • •Wegener’s granulomatosis • •Vasculitis
Churg-Strauss syndrome
Micropolyangiitis
Arthritis, arthralgia
Myalgia
Hermatological diseases
HUVS •AIHA
Pernicious anemia •ITP
Cryoglobulinemia
Autoimm. thrombosis • • •
Gastrointestinal diseases
Atrophic gastritis
Celiac disease • •Celiac (IgA-deficient) • • •Crohn’s disease
Ulcerative colitis
Liver diseases
CAH •CAH / HBsAg positive CAH / HCV positive
Viral hepatitis
Drug induced hepatitis
PBC •PSC
PBC / PSC overlap syndrome
Renal diseases
Goodpasture syndrome •RPGN
Interstitial nephritis
Lupus nephritis • • • • •Hematuria, proteinuria
Postinfection GN
Cardiovascular diseases
Endocarditis lenta
Pericarditis
Dressler syndrome
Endocrine diseases
IDDM (new diagnosis) •Hashimoto’s thyroiditis •Grave’s disease •Hypoparathyroidism
Hyperthyroidism
Hypothyroidism
Autoimmune PEP I/II
Addison’s disease • •Fertility problems
Habitual abortion
Skin diseases
Pemphigus •Pemphigoid •Alopecia
Vitiligo
Dermatitis herpetiformis •Neurological diseases
Myasthenia gravis •Periferal neuropathy
>90% •50-90% •30-50% •10-30% •<10%
Freq
uenc
y
Dia
gnos
tic M
arke
r
Lege
nd
AChR acetylcholine receptorAIHA autoimmune hemolytic anemiaAMA antimitochondrial antibodiesANA antinuclear antibodiesANCA antineutrophil cytoplasmic antibodiesAPCA gastric parietal cell antibodiesAPS antiphospholipid syndrome ASCA anti-Saccharomyces cerevisiae antibodyBMZ basal membrane zoneBPI bactericidal permeability-increasing proteinß-2 GP1 beta-2 glycoprotein ICAH chronic autoimmune hepatitisCCP cyclic citrullinated peptidesCREST calcinosis, Raynaud phenomenon, oesophagus
dismotility, sclerodactyly, teleargiectasiaC1q complement proteinDIL drug induced lupusDM dermatomyositisds-DNA double stranded DNAEMA endomysium antibodyENA extractable nuclear antibodyGBM glomerular basal membraneGN glomerulonephritisGS-ANA granulocyte-specific ANAHBsAg hepatitis B virus antigenHCV hepatitis C virusHTG human thyroglobulinHUVS hypocomplementemic urticarial vasculitis
syndromeIC intercellularICA islet cell antibodyIDDM insulin dependent diabetes mellitus ITP idiopathic thrombocytopenia
JCA juvenile chronic arthritisJo-1 PM/DM antigenLA lupus anticoagulantLE lupus erythematosusLKM liver-kidney microsomal antibodyMCTD mixed connective tissue diseaseMPO myeloperoxidasePBC primary biliary cirrhosisPCNA proliferating cell nuclearantigen PEP polyendocrinopathyPM polymyositisPR-3 proteinase 3PSC primary sclerotic cholangitisPSS progressive systemic sclerosisRA rheumatoid arthritisRF rheumatoid factorRNP ribonucleoproteinRPGN rapid progressive
glomerulonephritisScl sclerodermaScl-70 scleroderma antigen (70kD)SLA soluble liver antigenSLE systemic lupus erythematosusSm Smith antigenSMA smooth muscle antibodySS-A Sjögren’s syndrome A antigenSS-B Sjögren’s syndrome B antigenss-DNA single-stranded DNATBM tubular basal membraneTPO thyroidperoxidaseTSH thyroid stimulating hormonetTG tissue transglutaminaseUCTD undifferentiated connective
tissue disease
Dia
gn
osi
s
Autoantibody Map
Edited by: Julianna Németh MD and Katalin Miklós PhD, National Medical Centre, Department of Immundiagnostics, Budapest, Hungary
Guidelines for diagnostic evaluation of autoimmune diseases
© HYCOR Biomedical, Inc., 2010P/N A60051 Rev. 7/10
www.hycorbiomedical.com
