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Damla Taykoz2020110077
BioTech 580Presentation
DRUG DISASTERS
15.11.2012
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1) Fenfluramine/phentermine (Fen-Phen)Wyeth-Ayerst Laboratories now Pfizer
Recalled: 1997 (after 24 years on the market)It is estimated that as many as 6.5 million people took it to help fightobesity
Financial damage: Awards to victims close to $14 billion, making it one of the mostcostly products liability cases in history.
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Cindy Cartwright took drug for 6monts has had to have three of fou
heart valves replaced
Linda M. took both diet drugs for
about 18 months
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2) Diethylstilbestrol (DES)
Maker: Multiple manufacturers
Recalled: 1975 (after 37 years on the market)Financial damage:Each manufacturer paid out legal damages correlated with itsrespective market share.
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3) Cerivastatin (Baycol)Maker: Bayer
Recalled: 2001 (after four years on the market)Financial damage:$1.2 billion
Baycol, prescribed to patients as a treatment for high cholesterol, is
reportedly responsible for more than 100,000 deaths
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4) Rofecoxib (Vioxx)Maker: Merck
Recalled: 2004 (after five years on themarket)
Financial damage: $6 billion
Vioxx is considered to be the largest drug recall inhistory, and one which elicited one of the greatestpublic outcries. Vioxx, prescribed to more than 20
million people as a pain reliever for arthritis, wasfound to be responsible for increased risk of heartattack and stroke.
Rofecoxib was approved
by the Food and DrugAdministration (FDA) on
May 20, 1999
5) Valdecoxib (Bextra)Maker: Pfizer
Recalled: 2005 after one year on themarket.
Financial damage: Over $2 billion
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6) Troglitazone (Rezulin)
Maker: Warner-Lambert
Recalled: 2000 (after one year on the market)
Financial damage: Warner-Lambert grossed $2.1 billion in salesbefore recall
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7) Phenylpropanolamine (PPA)
Maker: No principal manufacturer
Recalled: in 2000 (at least 60 years on the market)
Financial damage: untold millions
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8) Thalidomide
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Sources and References
www.fda.org
www.pubmed.com
www.pfizer.com
www.cumc.colombia.edu
www.drugbank.cahttp://www.agcs.allianz.com/
http://www.petroffassociates.com
http://www.shifa.com.pk
www.cnn.com
www.bbc.co.uk
www.nyu.eduhttp://science.education.nih.gov
http://www.nanogenpharma.com
www.cartoonstock.com
http://www.heart-valve-surgery.com
http://www.lawyersandsettlements.com
https://www.facworld.com/
http://desinfo411.wordpress.com/des-timeline/
http://www.huffingtonpost.com/
http://www.drugbank.ca/drugs/DB00255
Bilim ve Teknikl Dergisi
G E Mitchell and D R Mottram, Peripheral effects of fenfluramine, Br J Pharmacol. 1976
June; 57(2): 185189.
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mitchell%20GE[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mottram%20DR[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mottram%20DR[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mottram%20DR[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mitchell%20GE[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mitchell%20GE[auth]