BODY ‘S IMMUNE RESPONSE
DR. ANANDRAJ
WHAT IS IMMUNE POWER??
IS IT ONLY POWER?/OR ANYTHING ELSE?
REACTION TO HARMFUL AGENTSRESPONSE OF BODY TO EXTERNAL
TOXIC SUBSTANCES
IS IT NATURAL OR
ACQUIRED
IMMUNITY INNATE IMMUNITY (Ist Line Of Defense)
ACQUIRED /ADAPTIVE IMMUNITY(Immunity stimulated by microbes)
-LYMPHOCYTES-PLASMA CELLS
CELL MEDIATED IMMUNITY
(T Cells)
HUMORAL IMMUNITY(B CELLS)
EPITHELIAL BARRIERS
PHAGOCYTIC CELLS (PMN ; MACROPHAGES)DENDRITIC CELLS (Destroy viruses by producing Type 1 IFN)NATURAL KILLER (NK) CELLS
PLASMA PROTEINS (esp. COMPLEMENT PATHWAY)
What are the various immune organs in our body
Tissues of Immune SystemCENTRAL (GENERATIVE) LYMPHOID ORGANS
•THYMUS ( T Cells)•BONE MARROW (B CELLS)
PERIPHERAL LYMPHOIDORGANS
LYMPH NODEa) CORTEX (B Cell Zone) : Germinal Centersb) PARACORTEX (T Cell Zone)
SPLEENa) FOLLICLES ( B Cell Zone)
b) P A L S ( T Cell Zone)
CUTANEOUS ; MUCOSAL LYMPHOID SYSTEM
a) Under skin
b) Under Respiratory Tact ; GI Epithelium
WHAT IS THE ACTION /FUNCTION OF IMMUNE
IS GOOD TO BODYOR
HARMFUL??
IS IMMUNE POWER ALWAYS GOOD??
NO
WHAT ARE THE COMPONENTS OF IMMUNE RESPONSE
• INFLAMMATION• CANCER• HYPERSENSITIVITY [ALLERGY]• HEMODYNAMIC DISORDERS
Which cell is most commonly involved in immune responseLymphocytes
or neutrophils
IN+FLAMME
• IN- INSIDE
• FLAME- BURNING
• BURNING = IMMUNE RESPONSE TO HARMFUL
• ‘It is’
INFLAMMATION= ‘ITIS’
Is inflammation same as infection
• IS INFLAMMATION GOOD OR BAD??
PLAYERS OF INFLAMMATION
• INFLAMMATORY CELLS
• PROTEINS
• VASCULAR WALL CELLS
• CONNECTIVE TISSUE CELLS
• EXTRACELLULAR MATRIX
• ANTGEN&ANTIBODY
CELLS INFLAMMATORY CELLS
• NEUTROPHILS• EOSINOPHILS• BASOPHILS
GRANULOCYTES
CONNECTIVE TISSUE CELLS
• LYMPHOCYTES [T CELLS]
• MACROPHAGES
• MAST CELLS
• FIBROBLAST
Which cell is most commonly involved in immune response
Lymphocytes or Granulocytes
PROTEINS
• CIRCULATING PROTEINS• -- CLOTTING FACTORS
• KINOGENS=KININS
• COMPLEMENTARY FACTORS
VASCULAR WALL CELLS
• ENDOTHELIAL CELLS
• SMOOTH MUSCLE CELLS OF BLOOD VESSEL• [To control the tone of vessel]
ECM
• COLLAGE AND ELASTIN
• PROTEOGLYCANS
• GLYCOPROTEIN--FIBRONECTIN
• INFLAMMATORY CELLS
• PROTEINS
• VASCULAR WALL CELLS
• CONNECTIVE TISSUE CELLS
• EXTRACELLULAR MATRIX
• ANTGEN&ANTIBODY
BASIC REACTIONS INVOLVED IN INFLAMMATION
• Antigen –antibody Reaction
• Chemotaxis
• Phagocytosis -MACROPAHGES
• Hyperemia
• Vasodilators & Vasoconstrictors
CHEMOTAXIS– CHEMICAL+MOVEMENT
PHAGOCYTOSIS
• PLAYERS OF INFLAMMATION
• Basic Mechanisms of inflammation
CARDINAL SIGNS OF INFLAMMATION
CAUSES OF INFLAMMATION
CLINICAL EXAMPLES OF INFLAMMATION
Ag PRESENTING CELL (APC) : MHC T CELL : TCR
T CELL RECEPTOR (TCR)
MAJOR HISTOCOMPATIBILITY COMPLEX (MHC)
Michelangelo : The Creation of Adam
MHC and TCR : INTERRELATIONSHIP
Ag
Does inflammation occurs in newborn?
• What is the most common life threatening condition
DOES INFLAMMATION OCCURS AFTER SURGERY
• FACTORS INVOLVED IN INFLAMMATION• CARDINAL SIGNS OF INFLAMMATION• MECHANISM IN INFLAMMATION• CAUSES OF INFLAMMATION
THANKS