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Catalysis
Our Expertise and Capabilities in Homogeneous and Heterogeneous Catalysis
Catalytic Process Development Mechanistic investigations
Characterization of new catalysts Industrial catalytic
process design and optimization
Scale up/verification of designed/optimized catalytic processes
Preparation of tailored catalysts for development and scale up
Swedish Chemist Jöns Jacob Berzelius introduced the term ”Catalysis” in 1835
High-throughput Catalyst Screening
Identification and development of optimal
catalytic systems
Rapid identification of fit for purpose conditions
Enzyme catalyzed reactions through enzyme
kit screening
Methods for metal removal/recovery
0
10
20
30
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50
60
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80
90
100
ee ampy
ee daipen
ee dpen
ee dach
Catalytic cycle and reaction kinetics Metal-catalyzed reaction screen results
Pd(II)LBr
N
O
LPd(II)Br
N
O
N
O O
Pd(II)LH
Br
N
BrO
N O
O
N
O N O
O
Pd(0)L
Et3N
Et3NHBr
Pd(0)L2
k1
k-1
k2 k3
k4k5
BIPP
BMAP
• ChemSpeed™ reaction screening robot and glovebox for inert atmosphere handling and storage
• Buchi™ and Parr™ high temperature and pressure autoclaves (up to 500°C and 345 bar)
• Parr™ continuous reactor system (up to 500°C and 200 bar)
• Parr™ multiple reactor screening system (300°C, 200 bar)
• Endeavor™ multiple reactor screening system (200°C, 35 bar)
• Programmable tube furnace for preparation and development of new heterogeneous catalysts
Selected Experimental Capabilities
Molecular structure of metal- organic catalyst determined by X-ray crystallography
The Expert Team
R2
NOH
R2
NH2R1 R1RuCl(Cymene)(ligand) 1mol%H2, NH4X, Methanol, 90 oC
We provide • Design, development and mechanistic
investigation of (new) catalytic systems • Screening and development of methods for the
recovery of metals, ligands and/or support material for recirculation
• Scale-up/verification of designed/optimized catalytic processes (10-100L)
• Identification and development of optimal metal catalysts for chemical transformations
• Rapid identification of fit for purpose conditions to enable first manufacture of a desired molecule
• Industrial catalytic process design, development and optimization based on identified metal or enzyme catalysts
