www.medicoapps.org
Adverse Drug Reactions are important not only for various entrance exams like NEET PG ,
PLAB and FMGE but also very relevant in day to day clinical practice. Here is a compilation of
Adverse Drug Reactions (Which are relevant clinically as well often asked as MCQs in exams like
NEET PG , USMLE, PLAB and FMGE.
If you Like the compilation please don’t forget to download the PDF version and share this
compilation with your friends via facebook/twitter or any other means.
Antibiotics • Chloramphenicol
• Cotrimoxazole
• Nitroforantoin
Antiinflammatory • Phenylbutazone
• Indomethacin
• Diclofenac
Others • Zidovudin
• Felbamate
• Colchicine
• Trimethadione
• Methotrexate
• Phenytoin
• Cytosine arabinoside
• Phenobarbitone
www.medicoapps.org
Adverse Drug Reactions are important not only for various entrance exams like NEET PG ,
PLAB and FMGE but also very relevant in day to day clinical practice. Here is a compilation of
Adverse Drug Reactions (Which are relevant clinically as well often asked as MCQs in exams like
on please don’t forget to download the PDF version and share this
compilation with your friends via facebook/twitter or any other means.
Aplastic Anemia
Antirheumatic • Gold salts
• D penicillamine
Antithyroid • Carbimazole
• Methimazole
• Methylthiouracil
Cytotoxic drugs • Vincristine
• Adriamycin
• Methotrexate
• Chlorambucil
Psychotropic • Phenothiazine
Anticonvulsant
• Phenytoin (alpha methyl
hydantoin)
MegaloblasticAnemia
• Pentamidine
• Pyrimethamine
• Zidovudine
• Sulfasalazine
• 5-Fluorouracil
• Triamterene
• Primidone
• Azathioprine
• Trimethoprim
Adverse Drug Reactions are important not only for various entrance exams like NEET PG , USMLE,
PLAB and FMGE but also very relevant in day to day clinical practice. Here is a compilation of
Adverse Drug Reactions (Which are relevant clinically as well often asked as MCQs in exams like
on please don’t forget to download the PDF version and share this
Carbimazole
Methimazole
Methylthiouracil
Phenothiazine
Phenytoin (alpha methyl
hydantoin)
Triamterene
Primidone
Azathioprine
Trimethoprim
www.medicoapps.org
• Daunorubicin
• Emetine
• Lithium
• Amiodarone
• Oral contraceptives
• Cyclophosphamide
• Vitamin A
• Amiodarone
• Oral contraceptives
• Cyclophosphamide
• Busulfan
• Calcium channel
antagonist
• Digitalis
• Phenytoin
• Griseofulvin
• Isoniazide
• Methyldopa
www.medicoapps.org
Cardiomyopathy
• Phenothiazines
• Trastuzumab
• Sympathomimetics
• Doxorubicin
(Adriamycin
Hyperpigmentation
• Busulfan
• Minocyclines
• Corticotropin
• Bleomycin
• Phenothiazines
• Gold salts
• Chloroquine
• Clofazimine
Hyperpigmentation
• Vitamin A
• Minocyclines
• Corticotropin
• Bleomycin
• Phenothiazines
• Gold salts
• Chloroquine
• Clofazimine
Gynaecomastia
• Spironolactone
• Reserpine
• Estrogens
• Ethionamide
• Cyprotenrone acetate
• Clomiphene
• Testosterone
• Griseofulvin
• Ketoconazole
• Flutamide
• Goserelin
• Cimetidine
Sympathomimetics
Doxorubicin
(Adriamycin)
Phenothiazines
Gold salts
Chloroquine
Clofazimine
Phenothiazines
Gold salts
Chloroquine
Clofazimine
Testosterone
Griseofulvin
Ketoconazole
Flutamide
Goserelin
Cimetidine
www.medicoapps.org
Hyperprolactinemia and galactorrhea
• Estrogens
• Phenothiazines
(chlorpromazine)
• Butyrophenones(haloperidol)
• Opiates
• Fluoxetine
• NSAIDs
• Beta blockers
• Heparin
• Broad spectrum
antibiotics
• Clindamycin
• Cocaine
• Colchicine
• Digitalis
• Aluminium Hydroxide
• Barium sulphate
• Phenothiazines
• Ion exchange resins
www.medicoapps.org
Hyperprolactinemia and galactorrhea
Butyrophenones(haloperidol)
• Alpha
methylodopa
• Reserpine
• Verapamil
• Amitriptyline,
amoxapine
• Thioxanthenes
• Antiestrogen
• Metoclopramide
• Cimetidine
• Ranitidine
Precipitation of Asthma
• Opioids
• Heparin
• Disulfiram
• Nitrofurantoin
• Organophosphates
Diarrhea
• Magnesium antacids
• Donepezil
• Guanethidine
• Lactose
• Lincomycine
• Mesoprostol
• OCP
• Purgative
• Reserpine
• Ticlopidine
• Methyl dopa
Constipation
• Opiates
• Tricyclic
antidepresants
• Verapamil
• Ferrous sulphate
• Calcium carbonate
• Ganglionic
Thioxanthenes
Antiestrogen
Metoclopramide
Cimetidine
Ranitidine
Nitrofurantoin
Organophosphates
Purgative
Reserpine
Ticlopidine
Methyl dopa
Ferrous sulphate
Calcium carbonate
Ganglionic blockers
www.medicoapps.org
• Cocaine
• Tricyclic
antidepressants
• Erythropoietin
• MAO inhibitors
• Theophylline
• Bretylium
• Quinidine
• Chlorpromazine
• Calcium channel
• Adenosine
First dose hypotension (First dose phenomenon)
• Prazosin
• Murumonab CD3
• Minoxidil
• Phenylbutazone
• Estrogens
• Indomethacin
www.medicoapps.org
Hypertension
• Cyclosporine
• Valdecoxib (NSAID)
• Oral contraceptives
• Glucocorticoids
• Sympathomimetics
• Clonidine withdrawl
• Rofecoxib (NSAID)
Hypotension
• Morphine
• Glyceryl trinitrate
• Amiodarone
• Clonidine
• Guanethidine
• Alpha blockers
• Fosphenytoin (I.V.)
• Diuretics
• Levo-dopa
• Blockers
• IL-2
• β-blockers (I.V.)
First dose hypotension (First dose phenomenon)
• Sargramostim
• ACE inhibitors
Captopril)
C H F
• β - blockers
• Verapamil
• Mannitol
• Carbenoxolone sodium
• Diazoxide
• CCBs
• Corticosteroids
Sympathomimetics
Clonidine withdrawl
Rofecoxib (NSAID)
Fosphenytoin (I.V.)
dopa
blockers (I.V.)
ACE inhibitors
Diazoxide
Corticosteroids
www.medicoapps.org
Precepitation of MI or
• Amphetamines
• Dipyridamol
• Excessive thyroxine
• Nifedipine
• Theophylline
• Minoxidil
• Anticonvulsants
• Bromocriptine
• Fluoroquinolones
• Levodopa
• Opioides
• β Lactam antibiotics
• Quinolones
• Acyclovir & Ganciclovir
• Isoniazid
• Meperidine
• Tramadol
• Pethidine
• Flumazanil
• Cocaine
www.medicoapps.org
Precepitation of MI or exacerbation of angina
• Alpha blocker
• Vasopressin
• Hydralazine
• Nicotine and cocaine
• Beta agonists
• Sumatriptan
• Ergotamine
• Methysergide
• Oxytocin
• Beta blockers
withdrawal
• Decongestants
Depression
• β – blockers
• Disulfiram
• Statins
• Estrogen (OCPs)
• Benzodiazepines
• Interferon
• Barbiturates
• Calcium channel
blockers
Seizures
• Local anaesthetics
• Cyclosporine
• OKT3
• Tacrolimus
• Interferons
• Antidepressants
• Nalidixic acid
• Amphetamine
• Phencyclidine
• Antipsychotics
• Lithium
• Theophylline
• Alcohol withdrawl
• Barbiturate withdrawl
• Benzodiazepine
withdrawl
• Physostigmine (iv)
• Methyphenidate
• Vincristine
Ergotamine
Methysergide
Beta blockers
withdrawal
Decongestants
Benzodiazepines
Interferon- α
Barbiturates
Calcium channel
Antipsychotics
Theophylline
Alcohol withdrawl
Barbiturate withdrawl
Benzodiazepine
withdrawl
Physostigmine (iv)
Methyphenidate
Vincristine
www.medicoapps.org
• Butyrophenones
(Haloperidol)
• Levodopa
• Reserpine
• Clonidine
• Methyldopa
• TCAs
• TCAs
• Theophylline
• β agonist
• Steroids
• Vitamin B12
• Amphotericin B
• Gentamicin
• ACE inhibitors
• Heparin
• ARBs (angiotensin
antagonists)
www.medicoapps.org
Extrapyramidal symptoms
• Methyldopa
• Metoclopromide
• Tricyclic
Antidepressants
• OCP 'S
• Phenothiazines
Sedation
• Anthistaminics
• Barbiturates
• Benzodiazepines
• Reserpine
Tremers
• Lithium
• Sympathomimetics (
agonists)
Hypokalemia
• Licorice
• α Blockers
• Diuretics
• Lithium(AI13)
• Theophylline
• Penicillin derivatives
• Toluene abuse
• Carbenoxalone
• Insulin
• CA inhibitors
Hyperkalemia
• Trimethoprim
• NSAIDS
• Succinylcholine
• Pentamidine
• Digoxin toxicity
• K+ sparing diuretic
• Cyclosporine
• β -blockers (initially)
Phenothiazines
Benzodiazepines
Reserpine
Sympathomimetics (β2 -
Penicillin derivatives
Toluene abuse
Carbenoxalone
CA inhibitors
Digoxin toxicity
K+ sparing diuretic
Cyclosporine
blockers (initially)
www.medicoapps.org
• Pyrazinamide
• Ethambutol
• Diuretics
• Cyclosporine
• Insulin
• Sulfonylureas
• ACE inhibitors
• Asparaginase
• Chlorthalidone
• Diazoxide
• Encainide
• Thyroid hormones
• Glucagon
• L-Asparaginase
• β -adrenergic agonists
• β -blockers
(propranolol)
• Calcitonin
• Plicamycin
www.medicoapps.org
Hyperuricemia (gout)
• Alcohol
• Levodopa
• Nicotinic acid
• Chlorthalidone
• Cytotoxic drugs
• Aspirin (Low dose)
Hypoglycemia
• Ethanol
• Pentamidine
• Octreotide
• Quinine
• Sulfonamide
• Salicylates
Hyperglycemia
• Ethacrinic acid
• Frusemide
• Glucocorticoids
• Growth-hormone
• Vacor
• Cyclosporine
• HIV protease inhibitors
• α -IFN
• Niacin
• OCP
• Phenytoin
• Clozapine
• Tacrolimus
• Pentamidine
• Thiazides
• Protease inhibitors
Hypocalcemia
• Gallium nitrate
• Bisphosphonates
• Phenytoin
Chlorthalidone
Cytotoxic drugs
Aspirin (Low dose)
Sulfonamide
Salicylates
Phenytoin
Clozapine
Tacrolimus
Pentamidine
Thiazides
Protease inhibitors
Phenytoin
www.medicoapps.org
• Cholecalciferol
• Estrogen
• Glucocorticoids
• Furosemide
• OCPs
• Thiazide
• Aminosalicylicacid
• Sulfonamides (Sulfamethoxazole)
• Nitrofurantoin
• Analgesics - Aspirin, Acetanilid
• Vitamin K (water soluble form)
• Probenecid
• Cotrimoxazole
• Niridazole – Phenazopyridine
• Quinidine
Hemolyticanemia (even without deficiency of G
• Isoniazid
• Rifampicin
• Sulfonamide
www.medicoapps.org
Hypercalcemia
• Calcium(IV)
• Thiazides
Hypertriglyceridemia
• Retinoic acid
• Bile acid - binding
resin
• Thiazides
• HIV protease
inhibitors
• Ethanol
• β - blockers
Hypercholesterolemia
• Tegretol
• Cyclosporine
Hemolysis in G-6-PD deficiency
Sulfonamides (Sulfamethoxazole)
Aspirin, Acetanilid
Vitamin K (water soluble form)
Phenazopyridine
• Nalidixic acid
• Antimalarials — Primaquine, Quinine,
Chloroquine (sometimes)
• Vitamin C
• Phenacetin
• Chloramphenicol
• Methylene blue
• Procainamide
• Dapsone
• Doxorubicin
Hemolyticanemia (even without deficiency of G-6-PD)
• Quinidine
• Procainamide
• Penicillin
• Phenacetin
• Dapsone
• Melphalan
Thiazides
HIV protease
inhibitors
blockers
Cyclosporine
Primaquine, Quinine,
Phenacetin
Dapsone
Melphalan
www.medicoapps.org
Dysguesia (Altered taste sensations)
• Acetazolamide
• Biguanide
• Captopril
• Antibiotics –
Metronidazole
• Anticancer - cisplatin,
dacarbazine
• Anti-arrhythmatics-
amiodarone,
adenosine
• Phenytoin
• Calcium antagonists
• Aniline and its derivatives
• Aminophenols
• Aminophenones
• Chlorates
• Dapsone
• Local anaesthetics - Prilocaine,
Benzocaine
• Nitrites
www.medicoapps.org
Dysguesia (Altered taste sensations)
• Griseofulvin
• Lithium
• Metronidazole
• Penicillamine
• Rifampin
Metallic taste
• Disulfiram
• Antidiabetics-
phenformin
• TCA-Nortryptiline
• Anticonvulsants
• Acetazolamide
• Antithyroid drugs
• Gold
• Vincristine
Gingival hyperplasia
• Sirolimus
• Lamotrigine
• Cyclosporine
Methemoglobinemia
Prilocaine,
• Naphthalene
• Nitrates (Nitroglycerine is included in
nitrates)
• Nitrobenzenes and related compounds
• Oxides of Nitrogen
• Phenazopyridine
• Primaquine and related antimalarials
• Sulfonamides
Penicillamine
Rifampin
Acetazolamide
Antithyroid drugs
Vincristine
Cyclosporine
(Nitroglycerine is included in
Nitrobenzenes and related compounds
Primaquine and related antimalarials
www.medicoapps.org
Pseudotumorcerebri (Increased ICT)
• Amiodarone
• Glucocorticoids
(withdrawl)
• Quinolones
• Amiodarone
• Chloramphenicol
• Chloroquine
• Cisplatin
• Clioguinol
• Clofibrate
• Zalcitabine
• Procarbazine
• Polymyxin, colistin
Predominant sensory neuropathy
• Cisplatin
• Hydralazine
• Metronidazole
Predominant motor neuropathv
• Dapsone
www.medicoapps.org
Pseudotumorcerebri (Increased ICT)
• Mineralocorticoids
(withdrawl)
• Hypervitaminosis A
• Nalidixic acid
• Oral contraceptives
• Tetracyclines
• Sympathomimetics
Peripheral neuropathy
• Demeclocycline
• Disopyramide
• Ethambutol
• Ethionamide
• Glutethemide
• Hydralazine
• Isoniazid
• Didanosine
• Paclitaxol
• Mustine
• Nalidixic acid
• Nitrofurantoin
• Perhexiline
• Phenelzine
• Phenytoin
• Streptomycin
• Stavudine
Predominant sensory neuropathy
• Misonidazole
• Pyridoxine
• Taxol
• Vincristine
• Nucleoside analogues
(Dinanosine,
Stavudine)
Predominant motor neuropathv
• Suramine • Lead
Oral contraceptives
Tetracyclines
Sympathomimetics
Nalidixic acid
Nitrofurantoin
Perhexiline
Phenelzine
Phenytoin
Streptomycin
Vincristine
Nucleoside analogues
(Dinanosine,
Stavudine)
www.medicoapps.org
Pulmonary fibrosis
• Acyclovir
• Amiodarone
• Bleomycin
• Methotrexate
• Busulphan
• Carmustine
• Clofibrate
• Zidovudine
• Amphotericin-B
• Gemfibrozil
• Statin
• Cimetidine
• Phenformin
• Metformin
• Zidovudine
• Lithium
• Amiodarone
• Iodides
• Ethionamide
• Carbamazepine
www.medicoapps.org
Pulmonary fibrosis (pulmonary infiltrate or interstitial lung disease)
• Chlorambucil
• Vinblastin
• Cyclophosphamide
• Nitrofurantoin
• Procarbazine
• Gold
• Melphalan
• Methysergide
• Mitomycin
• Sulfonamides
• Penicillamine
Myopathy
• Glucocorticoids
• Cyclosporine
• Chloroquine
• OCPs
• Spironolactone
• Acetazolamide
• Danazol
• D penicillamine
• Daptomycine
• Gold
Lactic acidosis
• Zalcitabine
• Spironolactone
• Acetazolamide
• Salicylates
Hypothyroidism
• Sulfonamide
• Paraminosalycylic acid
(PAS)
• Carbimazole
• Phenylbutazone
• Phenobarbitone
• Rifampicin
• Acetazolamide
• Phenytoin
Melphalan
Methysergide
MitomycinC
Sulfonamides
Penicillamine
Acetazolamide
D penicillamine
Daptomycine
Acetazolamide
Salicylates
Phenobarbitone
Rifampicin
Acetazolamide
Phenytoin
www.medicoapps.org
• Amiodarone
A) Vestibular (primarily
• Aminoglycosides
• Mustine
• Quinidine
• Quinine
• Chloroquine
• Vancomycin
• Furosemide
• Ethacrynic acid
• Salicylates (high dose)
• Aminoglycosides
• Aspirin
• Bleomycin
• Chloroquine
• Cidofovir
• Aminosalicylic acid
• Amiodarone
• Isoniazid
• Phenylbutazone
www.medicoapps.org
Hyperthyroidism
• Iodides
Ototoxicity
B) Auditory (primarily)
• NSAIDs
• Ethacrynic acid
• Vancomycin
• Aminoglycosides
• Cisplatin
Deafness
• Cisplatin
• Quinine
• Erythromycin
• Ethacrynic acid
• Furosemide
• Interferon
• Mustine
hydrochloride
• Deferoxamine
Optic neuritis
• Streptomycin
• Quinine
• Penicillamine
• Chloramphenicol
• Ethambutol
• Phenothiazines
Furosemide
Interferon
Mustine
hydrochloride
Deferoxamine
Chloramphenicol
Ethambutol
Phenothiazines
www.medicoapps.org
• Sulfonamides
• Thiazides
• Barbiturates
• Mydriatics
• Synpathomimetics
Addison's disease (Medical adrenalectomy
• Metyrapone
• Aninoglutethimide
• Glucocorticoids
• Cyclosporine
• Cytotoxic drugs
• Anticonvulsants
• Antiarrhythmics : Procainamide,
disopyramide, propafenome, quinidine
• Anti-hypertensives : hydralazine,
methyldopa
• ACE inhibitors
• Beta-blockers
• Antithyroid-propylthiouracil, iodides
• Antipsychotics - Chlorpromazine,
lithium
www.medicoapps.org
Disturbed color vision
• Digitalis
• Ethambutol
• Quinine
• Streptomycin
Precipitation of glaucoma
• TCAs
• Corticosteroids
Addison's disease (Medical adrenalectomy)
• Cytotoxic drugs
(mitotane)
• Ketoconazole
Osteoporosis
• Excessive alcohol
intake
• Aluminum
• Excessive thyroxine
• GnRH agonist
• Heparin
• Lithium
SLE (antinuclear antibodies)
Antiarrhythmics : Procainamide,
disopyramide, propafenome, quinidine
hypertensives : hydralazine,
propylthiouracil, iodides
Chlorpromazine,
• Anti-convulsauts : Carbamazepine,
phenytoin
• Antibiotic : Isoniazid, minocycline,
macrodantin, sulphonamide
• Antirheumatic : Sulfasalazine
• Diuretics : Hydroclorothiazide
• Statins : Lovastatin, simvastatin
• Biologics : IFN, TNF-a inhibitors
• Anticancer : Bleomycin, asparginase
Streptomycin
Corticosteroids
Ketoconazole
GnRH agonist
: Carbamazepine,
Antibiotic : Isoniazid, minocycline,
macrodantin, sulphonamide
Antirheumatic : Sulfasalazine
Diuretics : Hydroclorothiazide
Statins : Lovastatin, simvastatin
a inhibitors
Anticancer : Bleomycin, asparginase
www.medicoapps.org
Androgenic drugs
• Acetazolami
de
• Anabolic
steroids
• Androgenic
progestins(N
orethisteron
e)
• Dihydroepia
ndrosterone
• Testosterone
• Danazole
• Corticotropin
• Metyrapone
• Phenytoin
• Streptomycin
• Acetazolamide
• Interferon
• β – blockers
• Antipsychotics
• Lithium
• Procainamide
• Isoniazid
• Phenytoin
www.medicoapps.org
Hirsutism
Non - androgenic drugs
Testosterone
Danazole
Corticotropin
Metyrapone
• Phenytoin
• Penicillamine
• Triamterene –
hydrochlorthiaz
ide
• Cyclosporine
• Minoxidil
• Penicillamine
• Phenothiazines
Hypertrichosis
• Diazoxide
• Corticosteroids
• Cyclosporine
• Psorelin
• Latanoprost
• Minoxidil
Decreased libibo(impotence)
• Clonidine
• Diuretics
• Methyldopa
• Oral contraceptives
• Sedatives
• TCAs
Pericarditis
• Anticoagulants
• Methysergide
• Minoxidil
• Hydralazine
Minoxidil
Penicillamine
Phenothiazines
Latanoprost
Minoxidil
Oral contraceptives
Sedatives
Minoxidil
Hydralazine
www.medicoapps.org
• Methyl testosterone
• Sulindac
• Methimazole
• Chlorpropamide
• Nitrofurantoin
• Nifedipine, verapamil
• Asparaginase
• Corticosteroids
• Didanosine
• Opioids
• Stavudine
• Oral contraceptives
• Amiodarone
• Carbamazepine
• Gold salts
• Nilutamide
• Captopril
• Phenytoin
• Aminoglycosides
• Amphotericin B
• Cephaloridine
• Cisplatin
• Colistin
www.medicoapps.org
Cholestatic jaundice
• Erythromycin,
Nitrofurantoin,
Rifampin
• Amoxicillin -clavulanic
acid, oxacillin
• Norethynodrel with
mestranol
• Chlorpromazine
• Methimazole
• Anabolic steroids,
busulfan, tamoxifen
• Cyclosporine
• Gold salts
Pancreatitis
• Thiazides
• Zalcitabine
• Estrogens
• Azathioprine
• Mercaptopurine
• Ethacrynic acid
• Pentamidine
• Sulfonamides
• Valproic acid
• Furosemide
Pulmonary eosinophilia
• Sulfasalazine
• Nitrofurantoin
• Penicillamine
• GM-CSF
• Propylthiouracil
• Bleomycin
• L-tryptophan
• Minocycline
• Contrast media
• Methotrexate
• Iodine
• Aspirin
Acute tubular necrosis
• Cyclosporine
• Intravenous immune
globulin
• Methoxyfluranes
• Polymyxin
• Radioiodinatedcontrast
medium
• Sulfonamides
• Tetracyclines
• Acetaminophen
Chlorpromazine
Methimazole
Anabolic steroids,
busulfan, tamoxifen
Cyclosporine
Gold salts
Ethacrynic acid
Pentamidine
Sulfonamides
Valproic acid
Furosemide
tryptophan
Minocycline
Contrast media
Methotrexate
Radioiodinatedcontrast
Sulfonamides
Acetaminophen
www.medicoapps.org
• Cephalosporine
• Rifampcin
• NSAIDS
• Allopurinol
• Chloroquine
• Iron salts
• Levodopa
• Methyldopa
• Metronidazole
• Naphthalene
• Nitrofurantoin
• Phenacetin
• Aminopyrine
• Phenolphthalein
• Thiazides
• Cytarabine
• Carbamazepine
• Aspirin
• Quinine
• Methotrexate
www.medicoapps.org
Interstitial nephritis
• Penicillins (esp.
methicillin)
• Furosemide
• Phenindione
• Ciprofloxacin
• Thiazides
• Sulphonamides
Urine disolouration
• Quinine
• Sulfonamides
• Anthraquinone
• Methylene blue
• Triamterene
• Amitriptyline
• Primaquine
• Rifampin
• Daunorubicin
• Doxorubicin
• Aminosalicylic acid
• Indomethacin
• Chlorzoxazone
• Heparin
• Phenazopyridine
• Phenindione
• Sulfasalazine
• Warfarin
• Riboflavin
Thrombocytopenia
• Chloroquine
• Busulfan
• Gold salts
• Daunorubicin
• PAS
• Sulfonamides
• Ethanol
• 6-mercaptopurine
• Chlorpropamide
• Cycophosphamide
• Methyldopa
• Quinidine
Ciprofloxacin
Sulphonamides
Aminosalicylic acid
Indomethacin
Chlorzoxazone
Phenazopyridine
Phenindione
Sulfasalazine
Riboflavin
mercaptopurine
Chlorpropamide
Cycophosphamide
Methyldopa
www.medicoapps.org
Interference with folic
acidabsorption
• Phenytoin
• Phenobarbitone
• Primidone
• Sulfasalazine
• Cotrimoxazole
Precipitating
• Barbiturates
• Oral contraceptives
• Griseofulvin
• Narcotic analgesics
• Aspirin
• Acetaminophen
• Atropine
• Bupivacaine
• NSAIDs (most
common)
• Bisphosphonates
• Chemotherapy
www.medicoapps.org
Folate deficiency
Inhibition of dihydrofolate
reductase
Impair folate metabolism
• Methotrexate
• Pyrimethamine
• Triameterene
• Pentamidine
• Trimethoprim
• Alcohol
Precipitating acute intermittent porphyria
• Estrogen
• Chlorpropramide
• Phenytoin
• Rifampicin
• Sulfonamides
SAFE drugs in Porphyria
• Penicillin and
derivatives
• Streptomycin
• Benzodiazepines
• Glucocorticoids
• Insulin
• Muscle relaxants
• Bromides
Peptic ulcer
• Clopidogrel
• Crack cocaine
• Glucocorticoids
• Mycophenolatemofetil
• Potassium chloride
Impair folate metabolism
Alcohol
Rifampicin
Sulfonamides
Glucocorticoids
Muscle relaxants
Bromides
Mycophenolatemofetil
Potassium chloride
www.medicoapps.org
Syndrome of
• Vasopressin or
desmopressin
• Vincristine or
vinblastine
• Phenothiazines
• Monoamine oxidase
inhibitors
Aggravation of my
• Aminoglycosides:- Streptomycin,
kanamycin, tobramycin
• Tetracyclines
• Nondepolarizing muscle relaxants :
Pancuronium, atracurium
• Local anaesthetics : Procaine,
xylocaine
• Quinine derivatives : Quinine,
quinidine, chloroquine
Drugs precipitating in urine and causing obstruction
• Antiviral: Acyclovir, atazanavir, indinavir,
• Sulfa drugs: Sulfasalazine, sulfadiazine, acetylsulfamethoxazole, acetylsulfasoxazole,
acetylsulfaguanidine
• Other: Triametrine, silicate,
• Metronidazole
• Cefamandole
• Procarbazine
www.medicoapps.org
Syndrome of inappropriate AIH (SIADH)
• Chlorpropamide
• Carbamazepine
• Cyclophosphamide
• Serotonin reuptake
inhibitors
• Oxytocin, high dose
• Nicotine
• Tricyclic
antidepressants
Aggravation of mysthenia gravis
Streptomycin,
Nondepolarizing muscle relaxants :
Local anaesthetics : Procaine,
Quinine derivatives : Quinine,
• Quinolones Ciprofloxacin, levofloxacin,
ofloxacin
• Macrolides : Erythromycin, azithromycin
• β-blockers : Propranolol, atenolol
• Antiarrhythmics : Procainamide,
phenytoin
• Miscellaneous : Penicillamine,
botulinum toxin
Drugs precipitating in urine and causing obstruction
atazanavir, indinavir,
Sulfasalazine, sulfadiazine, acetylsulfamethoxazole, acetylsulfasoxazole,
, silicate, guatfensin, magnesium trisilicate, ciprofloxacin.
Disulfiram like reaction
• Cefotetan
• Cefoperazone
• Moxalactam
• Chlorpropamide
Oxytocin, high dose
Nicotine
Tricyclic
antidepressants
Quinolones Ciprofloxacin, levofloxacin,
Macrolides : Erythromycin, azithromycin
blockers : Propranolol, atenolol
Antiarrhythmics : Procainamide,
Miscellaneous : Penicillamine, magnesium,
Sulfasalazine, sulfadiazine, acetylsulfamethoxazole, acetylsulfasoxazole,
Moxalactam
Chlorpropamide
www.medicoapps.org
Aggravation of mvsthenia gravis
• Antiarrhythmics
• Antimicrobials
• Antihistaminics
• Antidepressants
• Antipsychotics
• Prokinetic
• Sulphones
• Quinolones
• Ethosuximide
• Salicylates
• Tocainide
• Phynylbutazone
• Penicillins (ampicillin)
• Sulfonamides
• Diuretics
• INH
Serum sickness like drug
• Cefclor
• Sulfonamides
• Thiouracil
• Ciprofloxacin
www.medicoapps.org
Aggravation of mvsthenia gravis
: Quinidine, procainamide, disopyramide, propafenone,
amiodarone
Quinine, mefloquine, artemisinin, halofantrine, sparfloxacin,
gatifloxacin
: Terfenadine, astemizole, ebastine
: Amitryptyline and other tricyclics
: Thioridazine, risperidone
: Cisapride
Erythema muliforme (SJS/TEN)
• Cephalosporins
• Valproic acid
• Nalidixic acid
• Codeine
• Chlorpropamide
• Tetracyclines
• Piroxicam
• Lamotrigine
• Allopurinol
• Penicillins
Exanthematous reaction
• Phenytoin
• Carbamezapine
• Barbiturates
• Phenylbutazone
• Lamotrigine
(Nevirapine)
• Allopurinol
• Rifampicin
Serum sickness like drug reaction (SSLDR)
• Penicillins
• Barbiturates
• Allopurinol
• Propranolol
• Tetracyclines
• Carbamazepine
• NSAIDs
ide, disopyramide, propafenone,
Quinine, mefloquine, artemisinin, halofantrine, sparfloxacin,
Tetracyclines
Piroxicam
Lamotrigine
Allopurinol
Penicillins
Lamotrigine
Nevirapine)
Allopurinol
Rifampicin
Tetracyclines
Carbamazepine
www.medicoapps.org
• Phenylbutazone
• Sulfonamides
Cytotoxic drugs causing mucositis
• Bleomycin
• Methotrexate
• Amasacrine
• Actinomycin-D
a) Phototoxic
• Tetracyclines
• Nalidixic acid
• Phenothiazines
• Sulfonamides
• Thiazides
• Fluroquinolones
• Amiodaroneom
www.medicoapps.org
Granuloma in liver
• Allopurinol
• Quinidine
• Diltiazem
• Carbamazepine
Cytotoxic drugs causing mucositis
• Paclitaxel
• Hydroxyurea
• Daunorubicin
• Mithramycin
• Cytosine arabinoside
• Fluorouracil
• Etoposide
• Topotecan
Photosensitivity
b) Photoallergy
• Sulfonamide
• Chloroquine
• Sulfonylureas
• Chlorpromazine
• Griseofulvin
Diltiazem
Carbamazepine
Cytosine arabinoside
Fluorouracil
Etoposide
Topotecan