Current Areas of Space-Related Health Research
• Skeletal Tissue Engineering - Adult mesenchymal stem cells- Nanobiomaterial scaffold- Bioreactor requirement
Presenter: Rocky S. Tuan, Ph.D., Chief, Cartilage Biology and Orthopaedics Branch
Agency/Organization: NIAMS, NIH, DHHS
COLUMBIA ST-48The Effect of Microgravity on Calcium Metabolism and Bone Formation in Chick Embryo1992 NASA SPACE SHUTTLE MISSION SPACELAB JSTS-47PI: Tatsuo Suda (Showa University)
V
PolymerSolution(-Hydroxy Polyester)
18 kV
VoltageSource
Ground
PolymerCloud
Electrospun nanofibers
With seeded cells
Seeded cellsstained forcytoskeleton
Application of Electrospun Nanofibrous Scaffold for Cell-Based Tissue Engineering
Dynamic Culture Promotes Tissue Integration
Tissue-Engineered Cartilage Using Nanofibrous Scaffold, Human Adult Stem Cells, TGF-,
and Bioreactor
Promising Areas for Space-Related Health Research Collaborations
• Understand the mechanisms responsible for randomized gravity mediated enhancement of stem cell-based cartilage formation
• Design novel bioreactors based on microgravity related principles for improved tissue engineering applications.
Existing Resources to Facilitate Space-Related Health Research
Cartilage Biology and Orthopaedics BranchNIAMS, NIH
• Human resources - a unique consortium of biologists, engineers and surgeons
• Physical resources - instrumentation design and prototyping, mechanoactive bioreactors, biomaterial scaffold production, adult stem cell technologies, mechanical testing