Nonenveloped Fecal-oral route Clinical signs: jaundice, anorexia, nausea,
hepatomegaly Exerts severe effects in pregnant women
Hepatitis E Virus
Zoonotic pigs not obviously ill, display very mild liver
lesions on histopathologic examination widespread throughout the world Antibodies to HEV in pigs from countries
where HEV is endemic and many industrialized countries
Pig as animal reservoir host for HEV
HEV in pigs
All liver samples were collected from pigs at necropsy
One-third frozen at -70℃ remaining part fixed in 10% neutral buffered
formalin embedded in paraffin wax cut into 3 µm sections stained with hematoxylin and eosin
Tissue processing
focal infiltration of lymphocytes, plasma cells, and macrophages in hepatic sinusoids and the
portal triad
swine HEV infection occurs at a very young age (under 2 months) in Jeju pigs.
various hepatitis virus antigens have been detected in liver tissue
However, these viral markers are only transiently expressed during the incubation and early symptomatic periods of acute viral hepatitis and may not be present during active disease
immunohistochemistry is not particularly useful PCR method more sensitive and applicable as a specific
assay for the diagnosis of various infectious diseases individuals with swine-associated occupations at
possible risk of zoonotic infection.
Conclusions