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Pathway Diagram Key © 2003–2020 Cell Signaling Technology, Inc.
Akt
D2-type D1-type D2-type D1-type
cAMP
JNKMKK4/7
CellSurvival
CDK5
mTORC2
Apoptosis
Cell Stress,Cytokines
Environmental Toxins,Neurotoxins
GeneticMutations
MicrogliaActivation
Apoptosis
LRRK2 MutationPINK1 Mutation
Misfolding
Transcription
AggregationLewy Bodies
Proteosomal Degradation
Post-Synaptic Signaling Blocked
Neurodegeneration
Dopamine
Dopamine
DopaDecarboxylase
Tyrosine L-DOPA
DopamineMetabolism
Normal State Parkinson’s Disease State
Ca2+
Na+
ROS DJ-1
PINK1
PKA
PP1
CREB CREM ATF
DARPP-32
DARPP-32
Parkin
AC
TyrosineHydroxylase
REDD1
α-synuclein
α-synuclein
GαsGαi β,γβ,γ
Dopamine Signaling in Parkinson’s Disease
AM
PAR
NM
DA
R
AM
PAR
NM
DA
R
rev. 12/02/19
Dopamine Signaling in Parkinson's Disease
rev. 12/02/19