fish frog
chick
Walking the line of cytochrome P450 evolution
David R. Nelson
human
JGI Tree of Life July 18, 2006
(5)
(282)
(99)
(97)
(51)
(177)
(706)
Human Chr 1 vs. mouse
Phylogenetically Inferred Groups synteny viewer
Human Chr 1 vs. mouse and chicken
Phylogenetically Inferred Groups synteny viewer
Human Chr 7 vs. zebrafish
Phylogenetically Inferred Groups synteny viewer
Human Chr 5 vs. Ciona
Phylogenetically Inferred Groups synteny viewer
Human CYP2AC1P
Xenopus CYP2AC gene cluster
Human CYP2J2 and HOOK1
zebrafish CYP2P, CYP2V, CYP2AD and CYP2N gene cluster
chicken CYP2J cluster and HOOK1
Human CYP2ABFGST gene cluster
Xenopus CYP2Q gene cluster
Fugu CYP2Y1 and CYP2Y2 Zebrafish CYP2Y3
Human syntenic region of the Xenopus CYP2AB1 gene
Xenopus CYP2AB1
zebrafish syntenic region of the Xenopus CYP2AB1 gene
Chicken CYP2AB gene cluster
Human CYP2AB1P pseudogene
zebrafish KCNJ2 LILRA2 CYP2K gene cluster ABCA3
fugu centa1 RNPS1 CYP2K gene cluster ABCA3
tetraodon centa1 CYP2K gene cluster ABCA3
Xenopus centa1 CYP2W gene cluster c16orf28
chicken centa1 CYP2W gene cluster gpr146
human centa1 CYP2W1 gpr146
Synteny around the CYP2W and CYP2K gene clusters
Zebrafish Chr25 SETD6 CNOT1 CYP2X6-9 E2F4
Zebrafish Chr7 LEAP2 CYP2X10 zgc:100802 GOT2
Xenopus CNOT1 ---- zgc:100802 GOT2
chicken SETD6 CNOT1 ---- zgc:100802 GOT2
human SETD6 CNOT1 ---- zgc:100802 GOT2
Synteny around the CYP2X gene cluster
zebrafish CYP19 and gliomedin ortholog
human CYP19 and gliomedin
Ciona CYP20 and best BLAST hit to zebrafish gliomedin ortholog
human chr20 with CYP8A1 (2.7 Mb region)
human chr8 with CYP7A1, CYP7B1 (16 Mb region)
71 moss P450s with 48 additional plant sequences
Physcomitrella patens
Some things that seem impossible
may actually be possible
I’ll try anything once,
twice if I like it,
three times to make sure.