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www.mevis.fraunhofer.deBremen / Lübeck - Germany
Fraunhofer MEVIS
Institute for Medical Image Computing
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Contents
1. Overview2. Evolution and
structure3. Fraunhofer MEVIS4. Innovation chain5. Perspectives
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Computer assistance for image-based, personalized
diagnosis and therapy
Field of Work
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Til Mette
stern - April 2005
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CharacteristicsFocus on image-based SW solutions for clinicians Whole chain: early detection, diagnosis, therapy, monitoring Epidemiologically important diseases
Patient-individual solutionsTransdisciplinary approachClinical network 150+ clinical and scientific partners worldwide
Complete innovation chain basic research research prototype product
Medicine
IndustryScience
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Modality
2-D
3-D
Dynamic [t]
Radiography (MX, AX)
Computed tomography(CT, CTA)
Magnetic resonance imaging (MRI, MRA)
Ultrasound (US)
Image Modalities
…
…
MR Spectroscopy, Microscopy/Histology, …
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Why computer support?
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Why computer support?
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Dimensions of Competence
Diagnosis
Clinical Workflow
Early Detection Diagnostic Planning Procedure MonitoringTherapy
Organs
Liver
Lung
Breast
Brain
Heart/Vessels
Bones/Joints
Diseases (Tumor, Inflammation, Degeneration, etc.)
MethodsMeVisLab
Validation
Navigation
Risk analysis
Visualization
Quantification
Segmentation
Registration
Modeling/SimulationImaging/Modality
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Fields of Activity Algorithms, Software Applications &
Computing Visualization & Human Computer
Interaction Workflow, Clinical Usability, …
Intra-operative/-interventional Support Liver, Lung, Breast, …
Mathematical Modelling & Numerical Simulation Foundation Professorship at Jacobs University
MR Imaging & Physics Foundation Professorship at University Bremen
Image Registration Project Group at University Lübeck
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2. Evolution and structure
© Fraunhofer emerged from daughter of
2001
2003
1995
1997
1999
2005
2007
2009
1993
University Non-profit Commercial
MeVis Family Tree
::
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Structure since 01/2009Non-profit Commercial(75 employees) (230 employees)
Bremen USA Japan
51% 100%
50%
100%
41%
NL
BremenInstitute forMedical Image ComputingBremen
50%
EFRE
Bremen
S-HProject GroupImage RegistrationLübeck (since 04/2010)
50%
50%
EFRE
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3. Fraunhofer MEVIS
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■ 59 institutes in GER■ 17 000 employees■ about 1.6 billion
EURresearch budget
■ 2/3 from industry andpublic agencies
Fraunhofer Groups■ Information & Communication
Technology■ Life Sciences■ Microelectronics■ Surface Technology & Photonics■ Production■ Materials & Components■ Defense & Security
Fraunhofer Society
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59 Institutes in GER
Institutes
Branches, Working Groups, Application Centers
Karlsruhe
DarmstadtWürzburg
Jena
Stuttgart
Duisburg
Oberhausen
Nuthetal
Dortmund
München
SaarbrückenSt. Ingbert
MagdeburgHalle
DresdenLeipzig
Ilmenau
CottbusBraunschweig
BerlinPotsdam
Teltow
Aachen
Schmallenberg
Sankt Augustin
Erlangen
Nürnberg
Freising
Holzkirchen
Pfinztal
Freiburg
Efringen-Kirchen
RostockItzehoe
HannoverBremen
Euskirchen Chemnitz
WertheimKaiserslautern
Paderborn
Schkopau
LübeckBremerhaven
Fraunhofer Society
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Organization Chart
Institute DirectorProf. Peitgen
Extended BoardKG plus
Dr. Kuhnigk, Dr. Zidowitz,
Person of Trust
Management Board (KG)
Prof. Peitgen, Prof. Hahn,Prof. Preußer, Prof. Günther,
Prof. Fischer, Dr. Kraß, Dr. Lang, Dr. Prause, T.
Forstmann
AdministrationT. Forstmann
Advisory Board Persons of Trust
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Organization of Work Team-oriented Open-minded Self-organized Flexible Adaptive
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Prof. Dr. H. Maier
Dr. R. Jansen Dr. U. Niebling
Dr. C.J.G. Evertsz Dr. B. Gewiese
Prof. Dr.-Ing. E.R. Reinhardt
W. Märzendörfer
Chair:
ResearchFunding:
Industry:
Advisory Board of Fraunhofer MEVIS
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Prof. Dr. J. Hennig Prof. Dr. W.A. Kalender
Prof. Dr. R. Kikinis
Prof. Dr. H.-P. Bruch Prof. Dr. K.J. Klose Prof. Dr. M. Reiser Prof. Dr. U. Sure
Science:
Medicine/Clinic:
Uni Bremen: Jacobs University:
Prof. Dr. G. SzékelyProf. Dr. H.-P. Schlemmer
Prof. Dr. J. Falta Dr. A. Ziegler-Jöns
Advisory Board of Fraunhofer MEVIS
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Management Board
Prof. Dr. Heinz-Otto Peitgen Prof. Dr. Horst K. Hahn Dipl.-Betrw. Thomas Forstmann
Institute Director Deputy Institute Director Head of Administration
Prof. @ Uni Bremen Adj. Prof. @ Jacobs UniProf. @ Uni Boca Raton Research
Prof. Dr. Matthias Günther Prof. Dr. Tobias Preußer Prof. Dr. Bernd Fischer
Head of MR Imaging Head of Modeling & Simulation Head of PG Image Registration
Found.Prof. @ Uni Bremen Found.Prof. @ Jacobs Uni Head of MIC Institute
Prof. @ Uni Lübeck
Dr. Stefan Kraß Dr. Markus Lang Dr. Guido PrauseClinical cooperations Scientific personell Publicly funded
projectsIndustry projects Industry projects PR / Advisory BoardPublicly funded projects IPR / contracts Deputy
Head of Administration
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Dr. Jan-Martin KuhnigkIT, Software Development
Dr. Stephan ZidowitzQuality Management
Extended Management Board
22
Persons of Trust
Melanie Bohn
Bianca Lassen
Lars Bornemann
Dr. Benjamin Geisler
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Finance(MEVIS Bremen)
TEUR
Inv.BHH
EFREHB
HBHBHBHBHB
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Personnel(MEVIS Bremen)
MMS: ≈ 230CeVis: ≈
10
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Certification
Certificate for quality assurance (since 2005)
Introduction and application of a quality management system in compliance with EN ISO 9001 / 12.2000 EN ISO 13485 / 07.2003 (medical devices)
Scope: Research and development for image-based
medical diagnosis and therapy Development of software
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AwardsScientific Exhibit Award with Certificate of Merit(Radiological Society of North America)
Bundesverdienstkreuz erster Klasse für Prof. Peitgen(Bundespräsident Roman Herzog)
Karl Heinz Beckurts-Preis für Forschung und Innovation(Karl Heinz Beckurts-Stiftung)
Magna Cum Laude Award for Most Innovative Contribution(European Congress of Radiology)
Werner Körte Medaille in Gold(Deutsche Gesellschaft für Chirurgie)
Bremer Unternehmerpreis für Wissenstransfer (ASU, BJU)
Induction of Prof. Peitgen into Hall of Fame at FAU
Deutscher Gründerpreis 2006(Sparkasse, McKinsey, stern, ZDF)
Eurographics 2007 Medical Prize
Bernd-Artin Wessels-Preis 2007
RSNA 95/97/00-
02:
Oct 1996:
Dec 1999:
Mar 2005:
Apr 2005:
Mai 2005:
Feb 2006:
Sep 2006:
Sep 2007:
Nov 2007:
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Sep 12, 2006: ZDF studio in Berlin
German Founders Prize 2006
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4. Innovation chain
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Innovation Chain
Clinical Network
>150
Siemens
Hologic
Invivo
Philips
Europe, Asia, USA
INPUT OUTPUT
Toshiba
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Technical
Testing
Algorithmic
Development
R&D Structure at MeVis
MeVisLab: SW Platform for R&D, Prototyping, Evaluation & Integration
Idea Algorithm
Customization
Clinical
Testing
Network
Integration
ClinicalEvaluation
Prototype
Product
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Publicly Funded ProjectsBMBF: FUSION (6,75 WiMi + 1 MTRA) kostenn. Verlängerung
DOT-MOBI mit DKFZ, ITWM, MMS und Siemens (6 WiMi)
Kompetenznetz ASTHMA-MRI mit 6 klin. Partnern (1 WiMi) LungSys mit 12 Partnern (1 WiMi) PMRIT: Physiological MRI during Throbolysis (1,5 WiMi) Virtuelle Leber: Mathematische Modellierung der Leber mit div. Partnern (3,7 WiMi) bis 03/2015 Spitzencluster: Medical Valley mit Siemens, IIS und div. Partnern (1,5 WiMi) bis 09/2013
MoBiTech3: MALDI-AMK mit Bruker, ZeTeM, CUCA u.a. (1 WiMi) bis 12/2013
DFG: RFITT mit UKBF (0,5 WiMi)
Klinische FG Essen: LLS/A2 - OP (1 WiMi) kostenn. Verlängerung
Klinische FG Essen: LLS/B2 - Histologie (1 WiMi)
Lunge/COPD mit DKFZ (1 HiWi)
Lungenchirurgieplanung (1 WiMi + 0,5 MTRA + 1 HiWi)
Neurochirurgie-Risikoanalyse mit Marburg (1 WiMi + 1 HiWi)
EU: HAMAM mit EIBIR-Partnern und Industrie (2 WiMi) ESFRI: Euro-BioImaging mit EIBIR-Partnern (0,1 WiMi) bis 07/2013 ICT-VPH: FUSIMO mit Uni Dundee, TU Delft, SINTEF u.a. (3 WiMi) bis 12/2013
Andere: R.-Bosch-Stiftung: OP-Projektion mit Prof. Lamade, RBKH Stuttgart (0,4 WiMi) WFB: 3D-MALDI mit ZeTeM und Bruker (0,2 WiMi)
DHZB: Cardio-MRI in Congenital Heart Disease (0,8 WiMi)
J F M A M J J A S O N D J F M A M J J A S O N D J F M A M J J A S O N D J F M A M J J A S O N D2009 2010 2011 2012
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Cooperations with IndustryFraunhofer MEVIS MMS AG Siemens AG Stryker several others in publicly funded projects
OEM partners of MMS AG Siemens AG Hologic Philips/ Invivo Toshiba
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Breast Cancer Screening- Digital Mammography
Breast-MRI- Neoangiogenesis and Biopsy
Surgery Planning - Internet-based Service
Three Success Stories
Market share
>50%
>50%
>90%
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1. Breast-MRI: Tumor Dynamic & Biopsy
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2. Mammography WorkstationSoftcopy reading in digital mammography
Mammography Screening Bremen
EU Projects:- SCREEN- SCREEN-TRIAL
Today: World market leader with over 6.000 systems
Siemens: MammoReportPlus Reporting Station Hologic: LORAD Selenia Reporting Station
First prototype: master thesis
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3. Liver Surgery Planning
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certified
Japan
USA
Australia
China
Korea
Singapore
Taiwan
Egypt
Europe
Distant Service via Internet
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› Kyoto University Hospital, Japan › Yokohama City University Medical
School, Japan › Nagoya University Hospital, Japan› University Hospital Kanazawa, Japan› Kaohsiung University Hospital,
Kaohsiung, Taiwan› Lahey Clinic, Burlington, MA, USA› Massachusetts General Hospital, Boston,
MA, USA› University of California at San
Francisco, USA› Columbia University, USA› University of Michigan, USA› Universtity of California at Los
Angeles, USA› Washington University St. Louis, USA› Strong Memorial Hospital, Rochester,
NY, USA› NIH Clinic, Bethesda, MD, USA› State University Hospital, Groningen,
Netherlands› Lund University Hospital, Sweden› Verona University Hospital, Verona,
Italy› Naples University Hospital, Naples,
Italy› Univerity Hospital Sapienza Rome, Italy› Gleneagles Hospital, Singapore
› Charité Berlin, Campus Benjamin Franklin› Charité Berlin, Campus Buch› Charité Berlin, Campus Virchow› Allgemeines Krankenhaus Celle› Universitätsklinikum Essen› Johann Wolfgang Goethe Universität Frankfurt› Universitätsklinik Freiburg› Medizinische Hochschule Hannover› Klinikum Hof› Universitätsklinik Köln› Klinikum Krefeld› Klinikum Schleswig-Holstein, Campus Lübeck› Universitätsklinikum Mainz› Klinikum der Philipps-Universität Marburg› Klinikum rechts der Isar München› Universitätsklinik Tübingen
Status since 2003: > 5.000 plannings at MeVis ≈ 2.400 LDLTs ≈ 1.900 Tumor resections ≈ 700 Pancreas, kidney, spleen, …
GermanyAsia, USA, Europe
150+ Users Worldwide
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5. Perspectives
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Perspectives
New fields Modeling and simulation MR imaging Image registration
Personnel 82+ employees until 2013 at Fraunhofer MEVIS
MR ScannerMeVis Campus
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Modeling and Simulation
Jacobs University BremenFoundation professorship by Conrad and Lotti NaberModeling of bio-physical processesNumerical simulationExamples RF-Ablation of liver tumors Numerical flow simulation High focused ultrasound
Prof. Dr. Tobias Preußer
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MR Imaging & Physics
University Bremen – FB PhysicsFoundation professorship byStiftung Bremer WertpapierbörseOptimization of imagingDevelopment of new sequences and imaging protocolsExamples Arterial Spin-Label Imaging Diffusion Tensor Imaging
Prof. Dr. Matthias Günther
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Image Registration
Fraunhofer MEVIS – Project Group Lübeck University Lübeck – Institute of MathematicsBasic funding by State Schleswig-HolsteinAnatomically correct mapping and fusion of medical image dataExamples Registration of pre-, intra- und postoperative
images Multimodal image registration
Prof. Dr. Bernd Fischer
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