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n e w s l e t t e rwinter/spring 2007 ■ vol. 18 ■ no. 1

continued

Leaders in BiomedicineDr. Paul Nurse to Speak at the Program’s New Lecture Series

Under the sponsorship of the Harvard MD-PhD Program, a new school-

wide lecture series named “Leaders in Biomedicine” will feature Dr. Paul

Nurse as the inaugural speaker on

Thursday, March 15, 2007. The lec-

ture will take place at 4:00 p.m. in the

New Research Building of Harvard

Medical School, 77 Avenue Louis

Pasteur, Boston, Massachusetts. The

title of Dr. Nurse’s presentation is

“Great Ideas of Biology.” (see abstract

in sidebar on page 2).

Dr. Nurse shared the 2001 Nobel

Prize in Physiology or Medicine,

became president of The Rockefeller

University in September 2003. He

had previously served as chief execu-

tive of Cancer Research UK, the

largest cancer research organization

outside the United States. Dr. Nurse is noted for his discoveries about the

molecular machinery that regulates the cell cycle, the process by which a cell

copies its genetic material and then divides to form two cells.

In addition to the Nobel Prize, Dr. Nurse has

received many other honors, including the Albert

Lasker Award for Basic Medical Research and the

Royal Society’s Wellcome, Royal and Copley

medals. A fellow of the Royal Society, he is a

founding member of the U.K. Academy of

Medical Sciences, a fellow of the American

Academy of Arts and Sciences, and a foreign

member of the U.S. National Academy of

Sciences. He was knighted in 1999 and received

France’s Légion d’Honneur in 2002.

A special lunch seminar for students to meet

2IRENE CHEN

6LEADERSHIP

7CAMARADERIE & CAREERS

9CARTOON BY RAPOPORT

10FOR THE RECORD

Contents

Our MD-PhD class is simply crazy about medicine and science.

OBSERVANT bystanders may abbreviate the previ-

ous to “simply crazy,” especially if they had wit-

nessed the antics of our pre-matriculation summer

together. They are entitled to their opinion. From

marauding through the TMEC dressed up as

pirates on our first day of summer class to run-

ning wild through the streets of New York, we

bonded over cultural dinners, coffee shop runs,

dancing in Boston, and endless candid/hammed-

up photography. Oh and of course, there was sci-

ence, with discussions of late night benchwork

and our latest Nature read-

ings. After the summer

our class, tightly

bonded, enthusias-

tic, and often irrev-

erent, was ready

(or not) to tack-

le…MEDICINE

when the school

year began.

We are a group

with varied interests

and backgrounds,

drawn together by a

common passion for

basic science, clinical

medicine, and free

food. Our parents hail

from seven different

countries. We have

worked with organisms that range in genome size

from 30,000 to 3,000,000,000 base pairs. We have

birthdays in ten of the twelve months. And our

dorm rooms can be found on five of the six floors

of Vanderbilt Hall. These are but a few examples

that underscore the fact that our class simply

defies all conventional labels.

The Entering Class of 2006

Crazy About Medicine

Portrait of the artistThe portraits of the entering

class of 2006 shown on the following pages

were drawn by MD-PhD artist-in-residence

Erin Chen, with a guest appearance

by Cameron Sadegh to draw the

master artist herself (above).

cont inued on page 3cont inued on page 2

2 HARVARD MD-PHD PROGRAM n e w s l e t t e r

NEW LECTURE SERIESc o n t i n u e d f r o m p a g e 1

with Dr. Nurse is also planned for the day Athar

Malik, Year 2, will facilitate what is sure to be a lively

discussion in advance of Dr. Nurse’s lecture in the

afternoon.

The goal of this new lectureship, according to

Christopher A. Walsh, MD, PhD, Bullard Professor

of Neurology and director of the MD-PhD Program

since 2003, is to provide students and members of

the HMS academic community with direct exposure

to a wide range of existing leaders in contemporary

biomedicine by offering a public lecture series in

which such individuals are invited to speak on a sub-

ject of general interest. The MD-PhD Program antic-

ipates an enthusiastic response from the students and

the HMS community who participate in the first lec-

ture of the “Leaders in Biomedicine Series.”

Irene Chen Named Winnerof the Grand Prize of the GE & Science for Young Life Scientists

IRENE CHEN, Harvard MD-PhD class of 2007,

was awarded the Grand Prize for her paper on

“The Emergence of Cells During the Origin of

Life.” She received the award and the $25,000

prize money from Peter Ehrenheim, President

of GE Healthcare Life Sciences and Monica

Bradford, executive editor of the journal

Science.

The GE & Science Prize for Young Life

Scientists was established twelve years ago

by GE Healthcare, formerly Pharmacia, and

Science Magazine together with its parent

organization/publisher AAAS to help bring sci-

ence to life by recognizing outstanding PhDs

from around the world and rewarding their

research in the field of molecular biology.

The prizes were awarded at Stockholm’s Grand

Hotel, the venue of the original Nobel Prize

ceremony in 1901, on December 11, 2006.

ABSTRACT OF

Dr. Nurse’s Lecture:

“The Great Ideas of Biology”

Three of the ideas of biology are the gene the-

ory, the theory of evolution by natural selec-

tion, and the proposal that the cell is the fun-

damental unit of all life.When considering the

question of “what is life?”, these ideas come

together because the special way cells repro-

duce provides the conditions by which natural

selection takes place allowing living organisms

to evolve. A fourth idea is that the organiza-

tion of chemistry within the cell provides

explanations for life’s phenomena. A new idea

is the nature of biological self organization on

which living cells and organisms process infor-

mation and acquire specific forms.

3HARVARD MD-PHD PROGRAM n e w s l e t t e r

Below are accurate portraits and brief autobiographies thatdescribe each of the members of the first year MD-PhD class.We wrote these ourselves, but deftly employed the third person to convey a sense of deep significance and import.”

Jonathan Abraham was born in Montreal, and raised in a nearbycity called Laval in Quebec, Canada. In 1998, his family moved toQueens, NY. He went to Harvard as anundergrad and studied biochemistry.In his free time, Jonathan likes tospeak “freole” or “frenglish”—mix-tures of French and Haitian Creole,and French and English, although hequickly loses track—with his threebrothers and parents. Jonathan’sother hobbies include martialarts, and importantly, pokingfun at gullible people.

Milena Andzelm was bornin Canada just after her par-ents emigrated from Poland.In an effort to gain Milena herthird passport, everyonemoved to the United States where Milena grew up in San Diego,aptly named America’s Finest City. Milena came to Harvard for col-lege, where she concentrated in Biochemical Sciences and researched

the molecular mechanisms of Natural Killer cellimmune synapse formation. Perhaps because the

past winter was unseasonably warm in Boston,Milena decided to stay on the east coast forher MD-PhD. She still loves immunology, butcould stray as far as chemistry for her PhD,and keeps coming up with exciting newresearch areas to explore. In the carefree days

of her first year in the HST program, Milenalikes to find new running routes on this side ofthe river, continuously prove that you can walkeverywhere in Boston, bake (but not cook), and

spend time with her super smart, entertaining,and generally fabulous fellow MD-Phders.

Erin Chen was born in Beijing and grew up inUtah and Connecticut. She experienced the “life of the mind” at theUniversity of Chicago while studying molecular biology and math,researching stem cell regeneration of skeletalmuscle in the McNally lab, and painting. Forher graduate work, Erin would like to applyboth computational and experimentalapproaches to investigate molecular circuitry.

In her free time, Erin likes makingart, playing the piano, cooking reallygood food (and then eating it), and

galvanizing her colleagues intodressing like pirates.

Sarah Hill was born and raised inBismarck, North Dakota. She got her AB inbiochemical sciences from Harvard Collegein 2005 and her MSc inbiochemistry fromOxford

University on a Rhodes Scholarshipin 2006. Sarah is scientifically inter-ested in chromosome molecularstructure and dynamics during thecell cycle and after damage. She willlikely pursue a PhD in some form ofcancer biology. Aside from scienceSarah loves running marathons, golfing,seeing movies, and going to the theater inLondon and New York.

Stephen Huffaker was born in Boulder, Coloradowhere his life revolved around hiking, skiing, camp-

ing, sailing, family, and enjoying life. When hewas 17 his family moved to Crawfordsville,Indiana where his parents live today (despitepleas from Steve and his sister to move back to a more topographically interesting locale). Stillmissing the granola-head lifestyle, he went toUniversity of Wisconsin-Madison for undergrad

and thoroughly enjoyed his three-year tenurethere despite the ice age temperatures. Morerecently, he completed his PhD in spring of this year at the University of Cambridgeand the National Institutes of Health focus-ing on the genetics and molecular biology of schizophrenia. Steve is now a “guinea pig”student in a new MSTP partnered programthrough the NIH, Cambridge, Oxford, andHarvard. Though he’s obviously a glutton for

punishment, it takes little convincing for himto drop the books and head outdoors, particularly in the snow.

Mark Lee grew up in the quiet town of Mountain Top, PA, wherehe has fond memories of biking around the neighborhood andreading Hemingway. At an early point in his life, he could be quoted

as saying that he either wanted to be a philosopheror a theoretical physicist. As it turned out, hebecame fascinated by biology at Yale, didresearch on regulatory RNA molecules in theBreaker lab, and graduated with a BS/MS degree

The Entering Class of 2006

CRAZY ABOUT MEDICINEc o n t i n u e d f r o m p a g e 1

**The entering class of 2006 would like to thank the

entering class of 2004 for their wit and humor in

writing intro paragraphs for MD-PhD newsletters,

from which we have borrowed liberally.


in molecular biophysics and bio-chemistry. He spent the next year

at the Dana-Farber studying HIV,and is currently interested in infec-

tious diseases and immunology. Hefeels honored to be a part of such an

amazing class of future physician-scientists,and as the unofficial photographer, is in the

process of documenting their audacious, crazyjourney together.

Karolina Maciag was born in Plock,Poland. Once a medieval capital rife with

kings and dukes, the city and its refin-ery are now rife with. . .organic chemists.

Count three of four of her grandparentsamong the latter—it must be science inthe genes. Karolina moved to theWashington, DC area with herparents as a child. At HarvardCollege, she enjoyed herresearch project, investigatingmechanisms of RNA processingusing computational systemsbiology, so much that she stayedin the lab for a full year aftergraduating in 2004, rendering theUniversity’s efforts to get rid of herby granting a “diploma” in vain.Her interest in infectious diseaseimmunology and global health ledher to spend the subsequent halfyear volunteering in rural medical

clinics in Guatemala, on aRadcliffe Fellowship.Grateful that lab science isa mobile skill, Karolinareturned to Europe to domore computational biolo-gy research in the remain-ing half year. She’s nowglad to be back in Boston,where she is working tofind a synthesis of herresearch interests. Beyondlab/class, she enjoys hiking,tennis, and many outdoorsports, good books, andvisiting her kid brother.

Devarati Mitra is not quite sure where she’sfrom, though her best guess is somewherebetween Northern California, Belgium andWashington DC. She graduated last yearfrom Stanford University where she studiedbiology and political science. Her excitementfor research was sparked while studying themechanism of protein translocation at theNational Institute of Health, though since thenshe has also worked on nuclear transport andDNA repair. Her current research interest isfocused on neurodegenerative disease thoughgiven her track record so far it’s very possible thatwill be subject to change. So far she’s been havinga great time exploring Boston, getting to know heramazing classmates and looking forward to the rest of hertime here at HMS.

Yin Ren grew up in China and moved to the true north of the greatland of Canada when he was fifteen. He came to Boston and attended

MIT, not knowing that he would stay here foranother 12 years. He majored in Course VI

(electrical engineering and computer science)because the stuff he learned was really fun.Later, he found out that bio-electrical engi-neering was even more fun, so he didresearch in several different areas such asusing microfluidics and bioMEMS to studybiomolecules, engineering circuits for image-

guided radiation therapy, and designing roboticsto model breathing and the delivery of radiation.

He is not exactly sure how an engineer like himselfbecame so interested in MD-PhD, and he is still try-

ing to figure out what he wants to do in thefuture. His current interests are applyingbioMEMS and nanoparticles to study and curecancer. In his free time, he likes to play a lot of

soccer and basketball, cheer on the Pistons, sleep,eat good food, meet new

people, and read Science and Nature.

Cameron Sadegh graduatedfrom MIT this past June withbachelors in biology and chemicalengineering. During his time at the‘Tute, he competed on the gymnas-tics team, and in between crashesand injuries, he researched cell sig-naling in the Lodish Lab. Motivatedby sports, research, and medicine,Cameron finds great interest in oneday understanding what guides cellularand neuronal acrobatics!

EditorLinda Burnley

Assistant EditorJanelle O’Rourke

DesignerKathleen Sayre

This newsletter is published twice a year since it was first published in 1990.

©COPYRIGHT 2007

BY THE PRESIDENT AND FELLOWS OF

HARVARD COLLEGE

www.hms.harvard.edu/md_phd

MD-PhDPROGRAMn e w s l e t t e r

PHOTO CREDITS: LINDA BURNLEY, AND MOSHE JAKUBOWSKI

HARVARD MD-PHD PROGRAM n e w s l e t t e r 5

Jenny Yang grew up in China whereshe had to trudge through snow,uphill (both ways), in order to getto school everyday. Then, one day,she saw the light when she and herfamily moved to the sunny hills ofCalifornia to a city properlynamed Sunny Hills (of course),only to finally settle down in aneven sunnier and even more beau-tiful city, San Diego. In 2006, Jennygraduated from UCLA with both abachelors and a masters degree inmolecular, cellular, and developmen-tal biology. Today, Jenny has made a full cir-cle and is back to trudging through snow forschool, even if it is just across Longwood Ave.When the days get cold, Jenny often looks up residency optionsin CA; and when the schooling gets tough, she dreams of herother career aspirations: architect, fashion designer, food critic,talk show host, wedding planner, interior decorator, fortune-cookie-fortune writer, cancer-curer, and Nobel Prize winner.Channeling her nerdy side, Jenny, of course, is always dreamingabout the science that she works on. She is honored to have suchamazing people to call her colleagues and most importantly, herfriends.

Amy Saltzman was born in Cleveland, Ohio, where herfamily has lived for the past three generations. She spenta lot of time doing genetics and biochemistry in highschool, but in 2001, she left Cleveland to head furthereast for college. During her four years as an undergrad-uate at Princeton, she studied Anthropology and wasable to travel to Fiji to focus on experiences of postpar-tum illness and motherhood among ethnic Fijian

women amidst the country’s rapid economic andsocial transitions. Before coming to

HMS, Amy’s interests in medi-cine, anthropology, and moth-

erhood drew her to South Africato spend a year working for a non-

profit organization called moth-ers2mothers, which provides peer-based psychosocial support and edu-cation for pregnant women and newmothers who have recently beendiagnosed with HIV. Here in Boston,Amy is part of the joint MD-PhDprogram in medical anthropology.

She is proud to be one of the fewNew Pathways MD-PhD studentsand thrilled to be a part of such

an inspiring group of MD-PhD candidates.

New students at orientation with MD-PhD Program faculty. Front row (L-R): Jenny Yang, Milena Andzelm, Karolina Maciag, Aurore Halkovich*, and Mark Lee. Middle row (L-R):

Devarati Mitra, Jonathan Abraham, Erin Chen, Yin Ren, Cameron Sadegh, and Sarah Hill. Back row (L-R): Jordan Kreidberg, Maria Rupnick, Linda Burnley, Joel Hirschhorn, Chris

Walsh, Steve Blacklow, and Xavier Moissett*. (*Visting students from INSERM)

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Gastroenterology Attracts Future Trainees

Harvard MD-PhD stu-

dents Onyinye Iweala,

Sahar Nissim, Marlys

Fassett (left-to-right)

and Devarati Mitra (not

shown) attended the

first annual “Investing in

the Future: Attracting

MD/PhD Students into

Gastroenterology”

Workshop on February 10-11 in Miami, FL. The workshop was co-

organized by Dr. Rick Blumberg of Brigham & Women’s Hospital and

sponsored by the American Gastroenterological Association (AGA)

Institute. It offered 20 MD-PhD students the opportunity to receive

thoughtful career guidance from senior academic physician-scientists

in the AGA, including AGA President Mark Donowitz. Highlights

included scientific talks, a primer on NIH funding opportunities for

junior scientists by Judith Podskalny of the NIDDK, and a night out on

South Beach with GI fellows and young faculty. MD-PhD student par-

ticipants ranged from some who remain completely undecided about a

clinical specialty to those actively pursuing gastroenterological research

— students, keep this meeting in mind for future years!

L E A D E R S H I P C H A N G E S

Having served for three years as director of the MD-PhD

Program, Christopher A. Walsh, MD, PhD has decided that new

responsibilities he has assumed at Children’s Hospital and in his

laboratory, will preclude him from continuing as director of the

basic-science track of the program. He stepped down effective

February 1, 2007. Dr. Walsh is continuing as Bullard Professor of

Neurology at HMS and Beth Israel Deaconess Medical Center, as

Chief of the Division of Genetics at Children’s, and as a Howard

Hughes Investigator. He will also be leading a major new collabo-

rative research effort to understand autism.

According to Dr. Joseph Martin, the MD-PhD Program was

strengthened markedly during Dr. Walsh’s tenure. He fostered the

successful renewal of the MSTP grant, the launch of the social

sciences track of the program under the leadership of Dr. Allan

Brandt, and the identification of new sources of funding for stu-

dents who enter the program after the first two years. His active,

caring and effective mentoring will be remembered by the stu-

dents as hallmarks of his tenure. We are fortunate that he will

continue to be a part of our community.

We thank Dr. Walsh for his dedication and commitment and

wish him well in his continuing activities within the HMS com-

munity.

Stephen C. Blacklow, MD, PhD, associate professor of pathol-

ogy (BWH), is the interim director until a new director is

appointed.

Mel Feany, MD, PhD, associate professor of pathology, has

joined the program’s Executive Committee; her primary role

will be to co-direct the summer course “Molecular Biology of

Human Disease.”

Shown above are the program leaders and staff as they gathered after an executive

committee lunch meeting on February 2, 2007 (front: Steve Blacklow, Chris Walsh,

Linda Burnley; back from left: Yi Shen, Mel Feany, Janelle O'Rourke, Maria Rupnick,

Robin Lichtenstein, Joel Hirschhorn).

Minority RecruitmentLilit Garibyan (left) and Jose Aleman(right) traveled with Linda Burnley to

Anaheim, California last November to

represent the program at the 6th Annual

Biomedical Research Conference for

Minority Students (ABRCMS), a nation-

al meeting designed to encourage under-

graduate and graduate students to pur-

sue advanced training in the biomedical

and behavioral sciences. It is the largest

professional conference for biomedical

students attracting approximately 2,600

individuals, including 1,650 undergraduate students, 280 graduate

students, 30 postdoctoral scientists and 750 faculty and adminis-

trators. Students come from over 285 U.S. colleges and universi-

ties. All are pursuing advanced training in the biomedical sciences,

and many have conducted independent research. Other partici-

pants from Harvard included Drs. James Hogle (Biophysics) and

Jocelyn Spragg (DMS) in addition to John McNally (HILS). The

next ABRCMS conference will be held November 7-10, 2007 in

Austin, Texas. Students or faculty interested in assisting in recruit-

ment for the MD-PhD Program should contact Linda Burnley.


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notes

7

Poster Sessions 2006

Poster sessions are the life blood of any medical scientist train-

ing environment and the MD-PhD Program is no exception.

On any given week, students are invited to participate in pre-

senting or attending poster sessions. Shown below are some of

the posters exhibited at the MD-PhD Program/Joslin Diabetes

Poster session held on the HMS campus last August, 2006.

Marie Hollenhorst (left) – Synthetic

Studies of the Galbulimima Alkaloids

(Movassagi lab); Sarah Hill (right)

“Dynamics of Cohesin Chromosomal

Association (Nasmyth lab-Oxford, UK)

Jonathan Abraham –

Characterization of the Machupo

Virus Surface Glycoprotein

Receptor Binding Domain

(Farzan and Choe lab)

Jennifer Villasenor – Exploring

the molecular mechanism of

aire (Mathis/Benoist lab)

Vincent Auyeung – Gene Expression

Profiling of NOD CD4+CD25+

Regulatory T Cells (Mathis/

Benoist lab)

Zachary Morris with his family tak-

ing a break from “Molecular function

of Merlin in membrane organization”

(McClatchey lab)

PHOTOS BY MOSHE JAKUBOWSKI

Camaraderie & Careers: The Women’s DinnersSince 1994, the MD-PhD program has sponsored an annual

women’s dinner to help strengthen connections between the

junior and senior women. In previous years, the dinner has

also provided students with the opportunity to talk openly

about women’s issues among each other and with women

faculty and to learn from others’ experiences. Finally, after

a two year hiatus, the women’s dinner came back as a won-

derful success, due to the efforts of Linda Burnley and the

generous offer of Judy Lieberman,

Professor of Pediatrics, to open her

home in Brookline to the program.

On the evening of January 23, over

40 women students and faculty gath-

ered to enjoy excellent food and

company. The older students on the

wards and dispersed in labs had the

opportunity to catch up with each

other, as well as bounce research ideas off

faculty and fellow students. The new students had the

opportunity to spend time together outside of class, as well

as solicit advice from both older students and faculty. Topics

discussed, including many recurring key themes, ranged

from what to look for in a thesis lab to how to balance chil-

dren and family with a career, and the evening was a pleas-

ant balance of catching up, camaraderie and personal and

career advising. Thank you again to Judy Lieberman for

hosting such a wonderful event! — by Milena Andzelm

Above, left to right: Chinfei Chen, Rebecca Spencer, Judy Lieberman, Lilit Garibyan,

Linda Burnley, Hanna Chang, Marlys Fassett, Onyi Iweala, and Roya Khosravi-Far.

Below: Dr. Judy Lieberman and Lilit Garibyan.

HARVARD MD-PHD PROGRAM n e w s l e t t e r

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A Brief Report on the 24th Annual Retreat

After another year spent in MD or PhD courses, in the lab and on the wards, it was great to get together last fall, October 13-15,

2006, with our MD-PhD classmates, faculty and program administrators and relax. We began the weekend with our lovely fleece

vests and dinner in the dining room. It’s really amazing how many desserts there are to choose from! Our evening of talks from both

senior and junior students included subjects from immunology to metabolomics. That evening, people found many ways to enter-

tain themselves, as always. The next morning we all grabbed a quick breakfast (or slept through it!) and then enjoyed a morning of

senior student presentations, from biochemistry to infectious disease.

Dr. Judah Folkman, the Julia Dyckman Andrus Professor of Pediatric Surgery, gave an inspiring talk [the Eva Neer Memorial

Lecture: “Angiogenesis: An Organizing Principle in Biology and Medicine?”], taking us all through his career and demonstrating the

unanticipated outcomes of clinical work and basic bench investigation. His career makes it clear that it is possible to merge clinical

and research interests into a seamless, fulfilling path—which is a great thing to remind us on our long path to our combined degrees.

After our outdoor group picture and a quick lunch, we headed out for hikes, hot tub soaks and shopping and chats. Most of us even

made it back for the poster session.

It’s great to actually get a sense of what our friends spend all their time in lab working on. Our lobster bake was a nice break and

was followed by an after dinner game of medical trivia hosted by Athar Malik. The traditional dance was held later…to protect the

participants, I’ll say no more! The next morning our faculty panel on career transitions was a great introduction to key decision

points to look out for, and we all headed back to Boston with a new sense of purpose and great memories. We are looking forward to

the next retreat in 2007 to celebrate the retreat’s 25th anniversary. — by Sarah Henrickson

Gallery

HARVARD MD-PHD PROGRAM n e w s l e t t e r

notesAnnual Q&A SessionShown at right are Drs. Maria

Rupnick, associate program direc-

tor, and Nancy Oriol, HMS dean

for students, at the program’s

annual Q&A session held on

February 8, 2007 for students in

the final stage of thesis preparation

who are returning to clinics in

2007. Dr. Rupnick directs the HMS

Longitudinal Course in Clinical

Medicine that starts on April 9

and runs for seven weeks held

at the Brigham and Women’s

Hospital. A major goal of the course is to refresh the clinical

skills of students who are beginning their transition back

to full-time clinical clerkships. Shown at the right are Dan

Seeberg, Adam Friedman, Zuzana Tothova who attended

the meeting.

Above photos: (top) Retreat

Hikers; (middle) Dr. Maria

Rupnick and Dr. Judah

Folkman; (bottom) James

Rhee and Milan Bajmoczi


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Publications (as of July 2006)

Pau AK, McLaughlin MM, Hu Z, Agyemang AF, Polis MA, Kottilil S. Predictors forHematopoietic Growth Factors Use in HIV/HCV-Coinfected Patients Treated withPeginterferon Alfa 2b and Ribavirin. AIDS Patient Care STDS. 2006 Sep;20(9):612-9.

Radoshitzky SR, Abraham J, Spiropoulou CF, Kuhn JH, Nguyen D, Li W, Nagel J, SchmidtPJ, Nunberg JH, Andrews NC, Farzan M, Choe H. Transferrin receptor 1 is a cellularreceptor for New World haemorrhagic fever arenaviruses. Nature. 2007 Feb 7; [Epubahead of print]

Lara D, Abuabara K, Grossman D, Diaz-Olavarrieta C. Pharmacy provision of medicalabortifacients in a Latin American city. Contraception. 2006 Nov;74(5):394-9. Epub 2006Jul 17.

Westley E, Bigrigg A, Webb A, Haskell S, Blanchard K, Loftus-Granberg B, Sorhaindo A,Johnston K, Spiers A, Abuabara K, Ellertson C. Risk of pregnancy and external validity in clinical trials of emergency contraception. J Fam Plann Reprod Health Care. 2006Jul;32(3):165-9.

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C,Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA. Bothp16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocar-cinoma in the mouse. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52. Epub 2006Apr 3.

Yang L, Kowalski JR, Yacono P, Bajmoczi M, Shaw SK, Froio RM, Golan DE, Thomas SM,Luscinskas FW. Endothelial cell cortactin coordinates intercellular adhesion molecule-1clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhe-sion and transmigration. J Immunol. 2006 Nov 1;177(9):6440-9.

Bernstein-Hanley I, Coers J, Balsara ZR, Taylor GA, Starnbach MN, Dietrich WF. The p47GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3and mediate cellular resistance in mice. Proc Natl Acad Sci U S A. 2006 Sep19;103(38):14092-7. Epub 2006 Sep 7.

Balsara ZR, Misaghi S, Lafave JN, Starnbach MN. Chlamydia trachomatis infectioninduces cleavage of the mitotic cyclin B1. Infect Immun. 2006 Oct;74(10):5602-8.

Bolar DS, Levin DL, Hopkins SR, Frank LF, Liu TT, Wong EC, Buxton RB. Quantificationof regional pulmonary blood flow using ASL-FAIRER. Magn Reson Med. 2006Jun;55(6):1308-17.

Zhang WT, Mainero C, Kumar A, Wiggins CJ, Benner T, Purdon PL, Bolar DS, Kwong KK,Sorensen AG. Strategies for improving the detection of fMRI activation in trigeminalpathways with cardiac gating. Neuroimage. 2006 Jul 15;31(4):1506-12. Epub 2006 Apr 19.

Chen IA. GE Prize-winning essay. The emergence of cells during the origin of life. Science.2006 Dec 8;314(5805):1558-9.

Pe’er I, Chretien YR, de Bakker PI, Barrett JC, Daly MJ, Altshuler DM. Biases and reconcili-ation in estimates of linkage disequilibrium in the human genome. Am J Hum Genet. 2006Apr;78(4):588-603. Epub 2006 Mar 1.

Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, Schmidt L, Chen WG, Lin Y, Savner E,Griffith EC, Hu L, Steen JA, Weitz CJ, Greenberg ME. Brain-specific phosphorylation ofMeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine mat-uration. Neuron. 2006 Oct 19;52(2):255-69.

Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT,Ploegh HL. Identification by functional proteomics of a deubiquitinating/deNeddylatingenzyme in Plasmodium falciparum. Mol Microbiol. 2006 Sep;61(5):1187-95.

Dandapani SV, Sugimoto H, Matthews BD, Kolb RJ, Sinha S, Gerszten RE, Zhou J, IngberDE, Kalluri R, Pollak MR. {alpha}-Actinin-4 Is Required for Normal Podocyte Adhesion.J Biol Chem. 2007 Jan 5;282(1):467-77. Epub 2006 Nov 2.

Dandapani SV, Pollak MR. The glomerular filter: Biologic and genetic complexity. KidneyInt. 2006 Sep;70(6):980-2.

Dekker JP, Yellen G. Cooperative Gating between Single HCN Pacemaker Channels. J GenPhysiol. 2006 Nov;128(5):561-7. Epub 2006 Oct 16.

Dhand, A. The roles performed by peer educators during outreach among heroin addictsin India: Ethnographic insights. Soc Sci Med. 2006 Nov;63(10):2674-85. Epub 2006 Aug 14.

Friedman A, Perrimon N. High-throughput approaches to dissecting MAPK signalingpathways. Methods. 2006 Nov;40(3):262-71.

Kulkarni MM, Booker M, Silver SJ, Friedman A, Hong P, Perrimon N, Mathey-Prevot B.Evidence of off-target effects associated with long dsRNAs in Drosophila melanogastercell-based assays. Nat Methods. 2006 Oct;3(10):833-8.

Friedman A, Perrimon N. A functional RNAi screen for regulators of receptor tyrosinekinase and ERK signalling. Nature. 2006 Nov 9;444(7116):230-4. Epub 2006 Nov 1.


Con

gratu

latio

ns! PhDs Completed

We congratulate the following students who completed their PhDs during the last semester.

Amar Dhand, Holmes, Educational Studies at

Oxford University [Geoffrey Walford, Ph.D.]

Peer learning among a group of heroin

addicts in India: An ethnographic study

(12/06).

Brendan D. Galvin, HST, Biology at MIT. [H.

Robert Horvitz, Ph.D.] The Regulation of

Programmed and Pathological Cell Death

in C. elegans (9/06).

Brian P. Hafler, HST, Neuroscience (DMS)

at Harvard University. [David H. Rowitch,

M.D., Ph.D.] Transcriptional Regulation

of Olig2 in Motor Neuron Development

(11/06).

John W. Hanna, Peabody, BBS-Cell and

Developmental Biology (DMS) at Harvard

University. [Daniel J. Finley, Ph.D.] Func-

tional Analysis of Ubp6, a Proteasome-

Associated Deubiquitinating Enzyme (8/06).

Nicholas E. Houstis, HST, Biology at MIT.

[Eric Lander, Ph.D.] Reactive oxygen species

play a causal role in multiple forms of insulin

resistance (11/06).

Vidyasagar Koduri, HST, Biophysics (GSAS)

at Harvard University. [Stephen C. Blacklow,

M.D., Ph.D.] Folding and Maturation of

Lipoprotein Receptors (10/06).

Lakshminarayan Srinivasan, HST, Electrical

Engineering and Computer Science at MIT.

[Sanjoy K. Mitter, Ph.D. and Emery N.

Brown, M.D., Ph.D.] From Thought to

Action (7/06).

Anna L. Stevens, HST, Department of

Biological Engineering at MIT. [Steven R.

Tannenbaum, Ph.D.] Mechanical injury

and inflammatory cytokines affect cartilage

integrity and tissue homeostatis: A mass

spectrometric analysis of proteins with

relevance to arthritis (7/06).

Leo L. Tsai, HST, Biophysics (GSAS) at Harvard University. [Ronald L. Walsworth, Jr., Ph.D.]

Development of a Low-Field 3He MRI System to Study Posture-Dependence of Pulmonary

Function (7/06).

Ellen Yeh, HST, Biophysics (GSAS) at Harvard University. [Christopher T. Walsh, Ph.D.]

Enzymatic halogenation during natural product biosynthesis (7/06).

Shown above are (top) Professor Dan

Finley and John Hanna; Sahar Nissim

cheers for the "D-Fence"; Sagar Koduri

and Professor Steve Blacklow.

PH

OT

OS

BY

MO

SH

E J

AK

UB

OW

SK

I

THIS NEWSLETTER IS SUPPORTED IN PART BY THE NATIONAL INSTITUTES OF

HEALTH MEDICAL SCIENTIST TRAINING PROGRAM GRANT T32-GM07753-27.

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Berger MF, Philippakis AA, Qureshi AM, He FS, Estep PW 3rd, Bulyk ML. Compact, universalDNA microarrays to comprehensively determine transcription-factor binding site specificities.Nat Biotechnol. 2006 Nov;24(11):1429-1435. Epub 2006 Sep 24.

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Nolan EM, Ryu JW, Jaworski J, Feazell RP, Sheng M, Lippard SJ. Zinspy Sensors with EnhancedDynamic Range for Imaging Neuronal Cell Zinc Uptake and Mobilization. J Am Chem Soc. 2006Dec 6;128(48):15517-15528.

Safo PK, Cravatt BF, Regehr WG. Retrograde endocannabinoid signaling in the cerebellar cortex.Cerebellum. 2006;5(2):134-45. Review.

Turner DJ, Shendure J, Porreca G, Church G, Green P, Tyler-Smith C, Hurles ME. Assaying chro-mosomal inversions by single-molecule haplotyping. Nat Methods. 2006 Jun;3(6):439-45.

Wachterman MW, Sommers BD. The Impact of Gender and Marital Status on End-of-Life Care:Evidence from the National Mortality Follow-Back Survey. J Palliat Med. 2006 Apr;9(2):343-52.

Sommers BD. Protecting Low-Income Children’s Access to Care: Are Physician Visits Associatedwith Reduced Patient Drop-Out from Medicaid and CHIP?” Pediatrics. 2006 Jul;118(1):e36-42.

Sommers BD. Insuring children or insuring families: do parental and sibling coverage lead toimproved retention of children in Medicaid and CHIP? J Health Econ. 2006 Nov;25(6):1154-69.Epub 2006 Jun 5.

Srinivasan L, Eden UT, Willsky AS, Brown EN. A state-space analysis for reconstruction of goal-directed movements using neural signals. Neural Comput. 2006 Oct;18(10):2465-94.

Song YA, Hsu S, Stevens AL, Han J. Continuous-flow pI-based sorting of proteins and peptidesin a microfluidic chip using diffusion potential. Anal Chem. 2006 Jun 1;78(11):3528-36.

Stover EH, Chen J, Folens C, Lee BH, Mentens N, Marynen P, Williams IR, Gilliland DG, CoolsJ.Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain ofPDGFRalpha and is FIP1L1-independent. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8078-83. Epub 2006 May 11.

Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR.Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase viaAkt and PKClambda/zeta. Cell Metab. 2006 May;3(5):343-53.

Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR. Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12093-7. Epub 2006 Jul 31.

Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegue E, Depinho RA, Gilliland DG. FoxOsAre Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress.Cell. 2007 Jan 26;128(2):325-339.

Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR,Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, Depinho RA. FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis. Cell. 2007Jan 26;128(2):309-23.

Klein M, Tsai LL, Rosen MS, Pavlin T, Candela D, Walsworth RL. Interstitial gas and density segregation of vertically vibrated granular media. Phys Rev E Stat Nonlin Soft Matter Phys. 2006Jul;74(1 Pt 1):010301. Epub 2006 Jul 18.

Becker-Catania SG, Gregory TL, Yang Y, Gau CL, de Vellis J, Cederbaum SD, Iyer RK. Loss ofarginase I results in increased proliferation of neural stem cells. J Neurosci Res. 2006 Sep;84(4):735-46.

Kelly WL, Ii MT, Yeh E, Vosburg DA, Galoni Cacute DP, Kelleher NL, Walsh CT. Characterizationof the Aminocarboxycyclopropane-Forming Enzyme CmaC. Biochemistry. 2007 Jan 16;46(2):359-368.

Vaillancourt FH, Yeh E, Vosburg DA, Garneau-Tsodikova S, Walsh CT. Nature’s inventory ofhalogenation catalysts: oxidative strategies predominate. Chem Rev. 2006 Aug;106(8):3364-78.

Yeh E, Cole LJ, Barr EW, Bollinger JM Jr, Ballou DP, Walsh CT. Flavin redox chemistry precedessubstrate chlorination during the reaction of the flavin-dependent halogenase RebH.Biochemistry. 2006 Jun 27;45(25):7904-12.

Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell JM, Chitnis T, Khoury SJ, He Z. Protecting axonaldegeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoim-mune encephalomyelitis models. J Neurosci. 2006 Sep 20;26(38):9794-804.

Yiu G, He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci. 2006 Aug;7(8):617-27. Review.

For the RecordPerrimon N, Friedman A, Mathey-Prevot B, Eggert US. Drug-target identification in Drosophila cells:combining high-throughout RNAi and small-molecule screens. Drug Discov Today. 2007 Jan;12(1-2):28-33.Epub 2006 Oct 30.

Chen Q, Fisher DT, Clancy KA, Gauguet JM, Wang WC, Unger E, Rose-John S, von Andrian UH, BaumannH, Evans SS. Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules viaan interleukin 6 trans-signaling mechanism. Nat Immunol. 2006 Nov 5;7(12):1299-1308 [Epub ahead ofprint].

Tegeder I, Costigan M, Griffin RS, Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T,Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A,Lotsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ. GTP cyclohydrolase and tetrahydro-biopterin regulate pain sensitivity and persistence. Nat Med. 2006 Nov;12(11):1269-77. Epub 2006 Oct 22.

Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M,King RW, Gygi SP, Finley D. Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligaseand deubiquitinating activities. Cell. 2006 Dec 29;127(7):1401-13.

Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, FinleyD, Deubiquitinating enzyme UBp6 functions noncatalytically to delay proteasomal degradation. Cell. 2006Oct 6; 127 (1): 99-111.

Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol. 2006 Jul;8(7):700-10. Epub 2006 Jun 25. Erratum in: Nat Cell Biol. 2006 Aug;8(8):896.

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Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulinresistance. Nature. 2006 Apr 13;440(7086):944-8.

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HARVARD MD-PHD PROGRAM n e w s l e t t e r11

TOSTESON MEDICAL EDUCATION CENTER

260 LONGWOOD AVENUE, ROOM 168

BOSTON, MASSACHUSETTS 02115-5720

[email protected]

www.hms.harvard.edu/md_phd

TEL 617-432-0991

FAX 617-432-2791

H A R V A R D M E D I C A L S C H O O L

MD-PhDPROGRAMn e w s l e t t e r

Incoming MD-PhD Students, 2006-2007Jonathan Abraham of Rosedale, NY, received his ABdegree Cum Laude in Biochemical Sciences fromHarvard University in June, 2006.

Milena M. Andzelm of San Diego, CA, graduated fromHarvard University in 2006 with AB degree SummaCum Laude in Biochemical Sciences.

Erin (Yiyin) Chen of Greer, SC, graduated from theUniversity of Chicago in June 2006 with BA degree withGeneral Honors; Biological Sciences with Honors.

Sarah J. Hill of Bismarck, ND graduated from HarvardUniversity in June 2005 with AB degree Magna CumLaude Highest Honors in Biochemical Sciences and asRhodes Scholar received her MSc degree from OxfordUniversity in 2006.

Stephen J. Huffaker of Crawfordsville, IN graduatedfrom University of Wisconsin in 2002 with a BS inNatural Sciences with Honors (highest distinction) andthen received his PhD in Neuroscience from CambridgeUniversity, UK and NIMH, US in 2006.

Mark N. Lee from North Wales, PA graduated from Yalein 2004 with a BS and MS degrees Summa Cum Laude in Molecular Biophysics and Biochemistry.

Karolina Maciag, born in Poland and moved to Sterling,

VA at the age of 5, graduated from Harvard University in2004 with AB degree Magna Cum Laude in BiochemicalSciences.

Devarati Mitra of Rockville, MD received her BS degreewith High Honors from Stanford University in 2006 inBiological Sciences.

Yin Ren, born in China and moved to Canada at age of15, was awarded the degree of Bachelor of Science inElectrical Engineering, Minor in Biomedical Engineeringfrom the Massachusetts Institute of Technology in June2006.

Cameron Sadegh of Franklin Lakes, NJ graduated in2006 with a BS degree in Biology, minor in BiomedicalEngineering and BS in Chemical Engineering from theMassachusetts Institute of Technology.

Amy B. Saltzman of Gates Mills, OH, received her ABdegree with Highest Honors in Anthropology in May2005 from Princeton University. She joined the newsocial sciences track.

Jenny (Yawei) Yang from San Diego, CA, received her BS Degree, Summa Cum Laude, and MA degree inMolecular, Cell, and Developmental Biology from theUniversity of California, Los Angeles in 2006.

For the Record

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Save the DateNote these upcoming program events

C O N T I N U E D F R O M PA G E 1 1

LCCM Course April 9

Soma Weiss Day April 19

MD-PhD Revisit April 12-14

Annual Spring Dinner June 5

HMS Commencement June 7

MIT Commencement June 8

New class begins July 6

Summer BBQ July 11

MSTP National Meeting July 27-30

Poster Symposium August 2

25th Annual Retreat October 12-14