IAN Test Drive
Baylor• Principal Investigator: Dr. Robin Goin-Kochel• Study Title: Autism Treatment Network• Location: Baylor College of Medicine/Texas Children's Hospital• Inclusion: 1. Children between the ages of 3.0 –17.9; the subject will be
expected to complete the protocol by his/her eighteenth birthday. 2. Parent/Caregiver fluent in written and spoken English/ English spoken in the home with the child at least 75% of the time (because most assessment questionnaires are validated in English only). (Additional inclusion criteria, such as having an ADI-R/ADOS confirmed ASD diagnosis, will be done at the ATN site.)
• Exclusion: 1. Blindness precluding valid testing. 2. Deafness precluding valid testing. 3. Ongoing or planned participation in another research protocol that would either prevent successful completion of planned study testing or invalidate the results of study testing.
Baylor
Baylor
300 Subjects
Baylor
University of Iowa• Principal Investigator: Dr. Karla McGregor• Study Title: The Development of Word Meaning• Location: University of Iowa • Catchment area: Iowa or 100 miles of Iowa City• Inclusion: chronological age = 8 to 13 years; verbal; high-
functioning (not mentally retarded); normal hearing acuity• Exclusion: none• Sample size: 30
Iowa
Iowa
Multi-Center Baby Sibs Study• Principal Investigator: Dr. Joe Piven et al• Study Title: Brain Development in Infants at High Risk for Autism• Location: (Multi-center) University of North Carolina at Chapel Hill,
Washington University, University of Washington, Yale University• Inclusion: under 12 months of age; at least one older sibling with a
documented diagnosis of autism• Exclusion:• * Certain medical and genetic conditions • * MRI contraindication• * Non-English speaking
Baby Sibs (ACE Study, Joe Piven et al)0
1020
3040
Freq
uenc
y
0 2 4 6 8 10age_in_months
N=160
Exploring the Treatment Data
Treatments0
100
200
300
400
Num
ber o
f chi
ldre
n
0 5 10 15 20 25 30 35 40Number of Treatments
updated 18 Jun 2007
Number of Treatments per Child
Top Twelve Treatments Nationwide1. Speech and Language Therapy2. Occupational Therapy 3. Applied behavior analysis (ABA)4. Social Skills Group 5. Picture Exchange Communication System (PECS)6. Physical Therapy7. Visual Schedules8. Sensory Integration Therapy9. Social Stories10.Risperdal11.Casein-free diet12.Melatonin
Intervention Improvement Expected Improvement
ExpectedRisk
ExpectedBurden
N
Keppra 2.8 3.7 2.6 2.1 15
Ritalin 2.7 3.4 2.6 2.1 32
Feingold diet 2.7 2.8 1.1 3.4 15
Homeopathy 2.5 2.5 1.6 2.4 23
Melatonin 2.5 2.9 1.7 1.5 179
Clonidine 2.5 3.2 2.2 1.9 135
DTT 2.4 3.5 1.4 2.6 115
Prayer 2.4 2.9 1.1 1.2 133
Remeron 2.4 3.3 2.5 1.9 11
Parental Age
Parental Age0
200
400
600
800
Freq
uenc
y
20 25 30 35 40 45 50 55 60 65FathersAge
Moternal Age0
200
400
600
800
1000
Freq
uenc
y
20 25 30 35 40 45 50 55 60 65MothersAge
020
040
060
0
20 25 30 35 40 45 50 55 60 65 20 25 30 35 40 45 50 55 60 65
1 2
Freq
uenc
y
FathersAgeGraphs by gender_id
32.8
33.0
P=0.5
MaleFemale
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