IL-4 in TB
Dr. Huang-Pin WuDiv. Pul. Med., Dep. Int. Med., Chang
Gung Memorial Hospital, Keelung
CD 30 surface antigen
Distribution Macrophage Activated T, B, NK cells
Function T cell receptor-mediated cell death Activates NfB
Increased apoptotic cell % along with increased CD30+ cells
J Immunol 2001;167:1230
IL-4 might contribute to the apoptosis of M. tuberculosis–activated T lymphocyte
J Immunol 2001;167:1230
Anti-IL-4 inhibit elevation of CD30+ cell %
IL-4 enhanced macrophage endocytosis by activationof phosphatidylinositol 3-kinase
J Immunol 1999;162:4606.
IL-4 could inhibit the extracellular killing function of activated IFN-gamma induced macrophages.
J Immunol 1992;148:3578.
Conclusion
IL-4 was still important in macrophage function.
Patients with a high degree of IL-4 response might have attenuated macrophage activity, thus reducing their ability to fight M. tuberculosis.
IL-42
The second of the four exons in the alternative splice variant of IL-4 mRNA is omitted.
Regulation of human IL-4 activity
IL-42 IL-4
A higher ratio of IL-42 to IL-4 in latent tuberculosis patients compared with that in controls
Immunology 2004;112:669.
Tuberculosis patients expressed higher IL-42 mRNA than did controls
J Infect Dis 2000;181:385.
Patients with greater IL-42 expression had more extensive disease
J Infect Dis 2000;181:385.
Question
The capability for IL-4 and IL-42 production in T cells of tuberculosis patients ?
The relationship of chest radiographic patterns and IL-4 production capability ?
Conclusion The ratio of IL-42 to IL-4 was a key factor a
ssociated with disease severity in patients with active pulmonary tuberculosis.
The inefficient expression of IL-4 and IL-42 mRNA in stimulated PMBCs of patients with pulmonary infection.
IL-4 may play a similar role in pulmonary infection, either M. tuberculosis or nontubercular bacillus.