Leong PP, PhD
12/6/2014 1
Hypersensitivity
To describe pathophysiology and clinical outcome of the following clinical examples
Type I atopic dermatitis
Type II erythroblastoma fetalis
Type III systemic lupus erythematous
Type IV contact dermatitis
Autoimmunity
To describe the pathophysiology and clinical outcome of Grave disease and Hashimoto thyroiditis
Immunodeficiency
To understand the use of traditional chinese medicine (TCM) approach for immunodeficiency
12/6/2014 2
Pruritus dermatitis (red, flare up & extremely itchy)
Common in individual with history of hay fever or asthma
Associated with IgE antibody
12/6/2014 3
12/6/2014 4
Immune mediated skin rash (swelling, erythema, vesiculation) at the site of contact with a chemicals Poison ivy
Nickel metal in costume jewelry
Dyes, perfume and etc
Mediated by sensitized Th1 cells
12/6/2014 5
12/6/2014 6
Rh system antigen D
Two Rh blood type Rh positive
Dominant
More common in population
Rh negative
Incompatible haemolysis
12/6/2014 7
8 12/06/2013
First pregnancy baby safe Rh ve mother acquires anti-Rh antibodies
Second pregnancy and onwards (baby is Rh +ve) Haemolytic disease of newborn brain damage,
mental retardted and even death
12/6/2014 9
Production of antibodies against a multitude of self-antigen including DNA (single and double stranded), nucleolar RNA, histones, RBCs, platelets. The disease is caused by the direct activity of the auto-antibodies and also by deposition of soluble antibody-antigen complexes which deposit along the walls of small blood vessels inflammtion & cell damage
Graves Disease Hashimoto thryoiditis
Hyperfunction of thyroid gland
Bulging eye, nervousness, enlarged thyroid, fast heart beat
Hypofunction of thyroid gland
Fatigue, enlarged thyroid, slow heart beat
12/6/2014 10
Auto-antibody
against TSH
receptor
Self-reactive
CTL
11 11/06/2013 LPP
Healthy == well functioning immune system
Immunodeficiency Immune system is suppressed by certain factors
e.g. nutrition, lifestyle and etc
Vulnerable to disease, infection, allergy and even cancer
Chinese Medicine Textbooks (since thousand years ago) Natural herbs
Dietary therapy
Acupuncture
Tai Chi
12/6/2014 12
http://www.tcmpage.com/hpimmunedef.html
Food with immune stimulation properties Shiitake mushroom
Lentinan anti-viral, immune stimulant
Garlic, sesame seed, yogurt, fruits & vegetables
Micro-nutrient Beta carotene, zinc and vitamin A, E and C
Low fat diet
12/6/2014 13
http://www.tcmpage.com/hpimmunedef.html
Astragalus (Huang Qi) Strong immune enhancing effect increased
number & activity of WBC
Showed to restore function of immune cells in cancer patient
Ginseng Widely used
Protects the liver, stimulates immune system, prevents radiation damage to nerve cells; has antioxidant effects, prevents cancer
12/6/2014 14
http://www.tcmpage.com/hpimmunedef.html
Chi Spleen Tonic (Bu Zhong Yi Qi Tang)
12/6/2014 15
Astragalus (Huang Qi)
Licorice (Gan Cao)
Agelica (Dang Gui)
Ginseng (Ren Shen)
Tangerine Peel (Chen Pi)
Cimicifuga (Sheng Ma)
Buplerum (Chai Hu)
Atractylodes (Bai Zhu)
http://www.tcmpage.com/hpimmunedef.html
Immunenergy Formula - Shi Quan Da Bu Tang Used to treat immune deficiency & fatigue
Often used for post-cancer management
12/6/2014 16
Angelica (Dang Gui)
Cnidium (Chuan Qiong)
Peony (Bai Shao)
Rehmannia (Shu Di Huang)
Ginseng (Ren Shen)
Atractylodes (Bai Zhu)
Poria (Fu Ling)
Licorice (Gan Cao)
Astragalus (Huang Qi)
Cinnamon (Rou Gui)
http://www.tcmpage.com/hpimmunedef.html
Regulation of immune system
Potential to treat wide range of health problems including immunodeficiency
Effects Increase the T cell count
Increase number of phagocytes
Increase WBC count and mobility
12/6/2014 17
http://www.tcmpage.com/hpimmunedef.html
Traditional Chinese martial art may help to boost immune system in elderly people
Showed to mount a stronger immune response to vaccine
12/6/2014 18
Miranda Hitti, Tai Chi May Boost Immune System, Journal of the American Geriatrics Society
12/6/2014 19