‘‘Amphibian cars’’ for molecular imaging:Boerman and Oyen look at the challengessurrounding development of hybrid PET/MRIscanners and previews an article in this issue ofJNM introducing a molecular probe that pro-vides a signal in both modalities. . . Page 1213
Single-session PET/CT staging mammog-raphy: Heusner and colleagues compare thediagnostic accuracy of an all-in-one protocolof whole-body 18F-FDG PET/CT and inte-grated 18F-FDG PET/CT mammography withthat of a multimodality algorithm for initialbreast cancer staging. . . . . . . . . . Page 1215
Breath-hold PET/CT in lung cancer:Kawano and colleagues describe the ad-vantages of breath-hold over free-breathingPET/CT in providing more precise measure-ment of maximum SUVs. . . . Page 1223
Optimal imaging for paraganglioma:Koopmans and colleagues evaluate the diag-nostic accuracies of 111In-octreotide somato-statin receptor scintigraphy, 123I-MIBGscintigraphy, and morphologic imaging inpatients with highly suspected head and neckparagangliomas. . . . . . . . . . . . . . Page 1232
Gene modulation of 18F-FDG kinetics:Strauss and colleagues use PET imaging andhistopathologic results to assess the effects ofangiogenesis-related gene expression on 18F-FDG kinetics in patients with primarycolorectal tumors. . . . . . . . . . Page 1238
11C-choline PET in hepatocellular cancer:Yamamoto and colleagues explore the poten-tial utility of 11C-choline PETas a complementto 18F-FDG PET in the detection of hepatocel-lular carcinoma lesions. . . . . . . . . Page 1245
11C-(R)-PK11195 imaging in AD: Tomasiand colleagues report on a reference regionmodel for estimating the binding potential ofa PET radiotracer that shows increasedmicroglial activity and decreased vascularbinding in individuals with Alzheimer’sdisease. . . . . . . . . . . . . . . . . . . . . Page 1249
Opioidergic system and rewards: Schreck-enberger and colleagues use 18F-DPN toinvestigate the neurobiologic correlates ofreward dependence and discuss the implica-tions of these findings for predicting predis-position to addictive behavior. . . Page 1257
Voxel-based diagnosis of Alzheimer’s dis-ease: Mikhno and colleagues explore theutility of 11C-PIB PET imaging of amyloid-baccumulation in discriminating healthy in-dividuals from those with Alzheimer’s dis-ease. . . . . . . . . . . . . . . . . . . . . . . Page 1262
Novel transporter radioligand: Arakawa andcolleagues report on several methods forquantification of (S,S)-18F-FMeNER-D2, aPET imaging agent with promise for directestimation of norepinephrine transporter occu-pancy by antidepressants. . . . . . . . Page 1270
Reversal of vascular 18F-FDG uptake:Lee and colleagues evaluate serial changesin vascular 18F-FDG uptake in response tolifestyle interventions and discuss thepotential use of this technique in athero-genic risk reduction. . . . . . . . Page 1277
Gated SPECT in atrial fibrillation: Scia-gra and colleagues examine differences inmyocardial perfusion between simultane-ously acquired gated and nongated SPECTdata in patients with atrial fibrillation andprovide recommendations for optimal as-sessment. . . . . . . . . . . . . . . . . . Page 1283
Viability in ventricular aneurysms: Zhangand colleagues describe long-term benefits ofSPECT and PET in assessing the viability ofaneurysmal myocardium in patients withischemic cardiomyopathy and compareshort-term results in those undergoing re-vascularization or revascularization plusaneurysmectomy. . . . . . . . . . . . . Page 1288
THIS MONTH IN JNM 11A
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Human biodistribution of 99mTc-N-DBODC: Cittanti and colleagues assess thesafety profile and biodistribution of a newmyocardial perfusion tracer that promises toprovide early and high-quality SPECT imagesof the left ventricle. . . . . . . . . . . . Page 1299
Overview of SPECT/CT: Buck and col-leagues offer an educational review of thecurrent status and future prospects ofhybrid SPECT/CT in cardiac, neurologic,and oncologic applications. . . Page 1305
Diabetes and myocardial glucose use:Shoghi and colleagues investigate myocar-dial glucose metabolism in a rodent modelof type 2 diabetes and validate PETmeasurements of glucose uptake againstgene and protein expression of glucosetransporters. . . . . . . . . . . . . . . . Page 1320
Functional P-gp activity at the BBB:Bankstahl and colleagues use (R)-11C-verapamil PET and tariquidar, a new-gen-eration P-glucoprotein modulator, to studyfunctional activity at the blood–brain barrierin rats. . . . . . . . . . . . . . . . . . . . . Page 1328
Pharmacokinetics of 99mTc(N)-DBODC(5):Bolzati and colleagues elucidate the mechanismsof distribution, retention, and elimination of apromising myocardial imaging agent and de-
scribe the potential for extension to tumorimaging and noninvasive multidrug resistancestudies. . . . . . . . . . . . . . . . . . . . . . . .Page 1336
Imaging PtdE availability: Zhao and col-leagues report on the development of 99mTc-duramycin as a novel molecular probe forimaging phosphatidylethanolamine, a majorphospholipid externalized to the surfaceof apoptotic cells and accessible in necroticcells. . . . . . . . . . . . . . . . . . . . . . . Page 1345
Cytotoxicity of 111In-DTPA-hEGF: Caiand colleagues investigate the relationshipsamong human epidermal growth factor ex-pression, DNA damage, and cytotoxicity incells exposed to an Auger electron–emit-ting radiopharmaceutical. . . . Page 1353
PET/MRI in pancreatic cancer: vonForstner and colleagues compare uptake of18F-FDG, 18F-FLT, and 18F-FEC in humanpancreatic tumor cell lines in mice andcorrelate tumor uptake with gene expressionof membrane transporters and rate-limitingenzymes. . . . . . . . . . . . . . . . . . Page 1362
Bifunctional PET/MRI probe: Lee andcolleagues detail the development of a
bifunctional iron oxide nanoparticle probefor PET and MRI scans of tumor integrinavb3 expression. . . . . . . . . . Page 1371
99mTc-HMPAO in RA: Bennink and col-leagues assess the biodistribution and radia-tion dosimetry of 99mTc-HMPAO–labeledmonocytes in adult patients with rheumatoidarthritis and describe the potential applica-tions in noninvasive monitoring of therapyand disease progression. . . . . . . . Page 1380
18F-FDG in colorectal tumor cells:Sharma and Smith look at therapy-inducedchanges in tracer incorporation at thetumor cell level in response to conven-tional and novel chemotherapy agents.. . . . . . . . . . . . . . . . . . . . . . Page 1386
Case against radioiodine ablation: Hayand colleagues take issue with widely usedpostoperative radioiodine remnant ablationas adjuvant therapy in patients with well-differentiated thyroid carcinoma and out-line reasons for suggesting that ablation isoften the wrong choice. . . . . Page 1395
O N T H E C O V E R
The maximum SUV of free-breathing PET should not be accepted asaccurate, especially in the lower lung and for small pulmonary lesions.In this patient, blurring of 18F-FDG accumulation was more apparentin fusion free-breathing PET/CT (top) than in fusion breath-holdPET/CT (bottom). Breath-hold imaging realizes a complete matchbetween CT and PET and is thus recommended as part of the standardprotocol for lung cancer.
See page 1229.
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