Mazen Animal Health
Jennifer Filbey, Ph.D.
CEO
November 7, 2018
First in Class Edible Vaccines
Feed–Through Vaccines For Production Animals
Positive Disruption is our Mission
Producers need:• Increased biosecurity
• Increased production margins
• Decreased antibiotics usage
• Improved disease prevention
Key Unmet Needs in Production Animals
Mazen proposes:• Subunit vaccines (ARS)
• Cost effective
• Replaces antibiotics
• Efficacy demonstrated
Coccidiosis causes $3.5B in annual losses
Mazen & USDA-ARS are Joining Forces to Provide a Cost-
Effective Vaccine Solution to Coccidiosis
• Coccidiosis is currently managed using a cyclical approach of spray
or water-based live vaccines alternated with ionophore antibiotics
and other anti-coccidiosis measures
• We need a safer, more efficacious, easier to use and cost-effective
approach
ARS has sub-unit antigens shown to be
effective against Eimeria infections
• EF-1alpha
• 3-1e/profilin
• Gam82
Mazen can express sub-unit vaccines in
maize grain creating “edible” vaccines
• Can be dosed with feed
• Cost effective
• Can’t replicate
Lillehoj, H. S., Ding, X., Quiroz, M. A., Bevensee, E., and Lillehoj, E. P. (2005) Avian diseases 49, 112-117.
Lin, R.-Q., Lillehoj, H. S., Lee, S. K., Oh, S., Panebra, A., and Lillehoj, E. P. (2017) Veterinary parasitology 243, 79-84.
Jang, S. I., Lillehoj, H. S., Lee, S. H., Lee, K. W., Park, M. S., Cha, S.-R., Lillehoj, E. P., Subramanian, B. M., Sriraman, R., and Srinivasan, V. (2010) Vaccine 28, 2980-2985.
• Over 15 issued and pending patents• Process• Use• Enhanced immunogenicity• Promoters• Ex: 9,944,937
• Patents pending for PEDV and Valley Fever
• Strong IP estate in the U.S.
• Patents pending related to three antigens from USDA-ARS
Clear Defensible & Competitive Advantages
Global Vaccine Market is over $7BRevenue projected to reach $300M by 2026 with US & International
Sales
• Porcine Epidemic Diarrhea
Virus
• Valley fever
• Avian Coccidiosis
(50,000,000)
0
50,000,000
100,000,000
150,000,000
200,000,000
250,000,000
300,000,000
350,000,000
2020 2021 2022 2023 2024 2025 2026
Feline - Rabies
Canine -Rabies
Fish Vaccine -Trout
Feline -Panleuk, Calic,RhinoCanine -Parvo, Dist,HepFish Vaccine -Salmon
Poultry -Coccidiosis
PCV-2 -Swine/Piglet
PEDV -Swine/Piglet
Valley Fever -Canine
EBIT
Mazen Experienced Leadership TeamAnimal Health, Technical & Commercial Expertise
TEAM
Jenny Filbey,
PhD
Founder, CEO
CPA
CFO
John Howard,
PhD
Founder, CSO
Tom Overbay, DVM
Development
CPA
CFO
• World leader in protein
expression in maize grain
• CEO of ABI
• 30 years of biotech
experience
• Entrepreneur focused
on commercialization
of new technologies
• President of NPI
• Nektar, Nobex, Hoechst
• Regulatory, business
development, tech
operations
• Expedite Animal Health
• Finance & corporate
development
• Public & private
company experience
• Animal health, feed
ingredients & production
animal marketing
• Elanco
• Bayer
Candidate
Identified
Candidate
Identified
Kerryann
Kocher
Marketing
Experienced BoardAnimal Health, Technical & Commercial Expertise
TEAM
Kelly
Lechtenberg,
DVM
Terry Speizer,
MBARonan Molloy, JD
• President, Innovation
Stockyard
• Zoetis, Synbiotics,
Primus
• President of Midwest
Veterinary Services &
the Veterinary and
Biomedical Research
Center
• Infectious Disease
Model Specialist
• Food Animal
Production Consultant
• Serial entrepreneur
• Morro View Winery
• Domaine Alfred Winery
• Electec, Flextec
Jenny Filbey,
Ph.D.John Howard,
Ph.D.
• Entrepreneur focused
on commercialization
of new technologies
• President of NPI
• Nektar, Nobex,
Hoechst
• World leader in
protein expression in
maize grain
• CEO of ABI
• 30 years of biotech
experience
PoC Provides Value Creation
Implementation
Antigen
Production
PoC in
target
animal
Master Seed
Working
Seed
EfficacyPre-licensing
SerialsSafety
Key Risk Reduction Step
• Cost effective
• Safer to deliver
• More efficacious
• Global reach
Equity Financing Round is Open Targeting a $20M Raise
Fast to Market for First-in-Class Edible Vaccine
➢10+x multiple on
investment
➢Disrupt animal
disease prevention
globally
11
Jennifer Filbey, Ph.D.
CEO
+1-256-417-8568
www.mazenanimalhealth.com