HEALTH.2012.2.1.2-2: SYSTEMS MEDICINE: APPLYING SYSTEMS BIOLOGY APPROACHES FOR
UNDERSTANDING MULTIFACTORIAL HUMAN DISEASES AND THEIR CO-MORBIDITIES
Partners:- Donetsk national medical university
Departments of Histology, Cytology and Embryology, Propaedeutics of Internal Medicine, Department of Dermatology, Medical Biophysics, Medical Equipment and Clinical Informatics
-Laboratory of fundamental research (Institute of Urgent and Recovery Surgery)
MULTIFACTORIAL HUMAN DISEASES AND THEIR CO-MORBIDITIES
Embryonic development
Genotype
Diet, nutrients Environmental factors
Life Style
INTRINSIC AND EXTRINSIC FACTORS INTERACTION
Various clinical manifestation Co-morbidities???
DiabetesDiabetes
AtherosclerosisAtherosclerosis
ObesityObesity
Coronary diseases
Coronary diseases
Digestive system pathology
Digestive system pathology
Endocrinological disturbance
Endocrinological disturbance
Autonomic system dysregulacation
Autonomic system dysregulacation
Metabolical disturbance Metabolical disturbance
ImmunopatholgyImmunopatholgy
Co-morbidities of multifactorial diseases
Proposition
Gene polymorphism
Cells response and resistance to different stimuli
Investigation of Cross-interactions in regulatory axis and metabolic ways of affected organs and their dependence on
individual reactivity of organism
PATIENTS WITH:
PROPOSED DESIGN OF INVESTIGATION
ClinicalInstrumentalLaboratoryBiochemicalImmunoenzymological
METHODS:
ATHEROSCLEROSIS
ANGINA. INFARCTION OF MYOCARDIUM
ISCHEMIC STROKE
PEPTIC ULCERS OF STOMACH AND DUODENUM
MorphologicalImmunocytochemicalMoleculo-geneticBiostatistics, Neurocybernetics
PROPOSED DESIGN OF INVESTIGATION
Regulatory axis in affected organ, system
Interlinks / co-morbities
Organ specific regulators
Regenerative potential
Metabolic peculiarities
State of innate and adaptive immunity
Network analysis
PLATELETS
Participate in:
- atherothrombosis- inflammation- vessels remodeling- reparation
PROPOSED MODEL FOR ANALYSIS
In vitro analysis of: AggregationSensitivity to systemic and organospecific regulators
PLATELETS AS SENSORS OF CARDIOVACULAR SYSTEM AND MIRROW OF REACTIVITY
Intracellular signaling systemsGranules and hyaloplasm content Enzymes activity
PLATELETS
Are targets for:
- Hormones- Neurotransmitters- cytokines- chemokines
1. Establish the role and key determinants of reactivity of organism in organospecific pattern of multifactorial diseases.
2. Detect the key regulatory factors in development, progression and risk of co-morbid pathology associated with AS.
3. Develop the system of prognostic criteria of organospecific manifestation of atherosclerosis.
EXPEXTED RESULTS
DEVELOPMENT OF INDIVIDUALIZED STRATEGY OF THERAPY