2
ON-LINE CATALOG: www.labphs.com
Pharm-Sintez.Lab is a leading innovative company in the field of nuclear medicine,product development, custom peptide synthesis and chemical pharmaceutical tecnologies.
– Chemical substances– Peptides– Radiopharmaceuticals (kits)– PET Precursors– Pharmaceutical impurities
3
MSDS/COA/QC
ABOUT THE COMPANY
QUALITY CONTROL
DELIVERY
HOW TO ORDER
QUESTIONS
Pharm-Sintez.Lab is a leading innovative company in the field of nuclear medicine, product development, custom peptide synthesis and chemical pharmaceutical technologies. Since 1997 our talented team has been providing our customers only high quality of more than 10 different pharmaceutical substances. Since 2005 the company has been successfully working in the field of radiopharmaceutical production. With application of different radioactive isotopes such as 99mTc, 111In, 68Ga, 177Lu and 188Re it was possible to create 4 unique platforms for diagnostic and therapeutic purposes in radiology, most of which has been officially registered and successfully released on the market.
For each product we provide Material Safety Data Sheet, which you can download from our website. Certificate of Analyses and Quality Control data are provided with each order individually.
To perform quality control of our products we use only high standard analytical methods, such as HPLC/MS/NMR.
We can provide delivery all over World. Most of our products are stable at room temperature. For other products we are able to provide any special conditions for a safe transportation.
To place your order, visit our website labphs.com or contact us directly.Email: [email protected]: +7 (495) 796-94- 33
If you have any additional questions about our products or other services, please contact us directly via phone or email.
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SERVICES
PEPTIDES
CHEMICAL SUBSTANCES
Custom peptide synthesisChemical synthesisAnalytical research services
BuserelinGoserelinTriptorelinLeuprorelinOctreotide
Dimethyl fumarateLinezolidPemetrexedSofarenib tosylateLenalidomibNifedipineNimodipineTemozolomideMoxonidineFingolimodIbandronateBortezomibTamsulosinZoledronic acidLetrozoleTopotecan Hydrochloride
050505
1212121313
06060607070708080809090910101011
PHARMACEUTICAL IMPURITIES
PET PRECURSORS
Buserelin impuritiesOctreotide impurities
DOTA-TATEDOTA-tri-t-Bu-esterDOTA-ε-Lys-octreotideDOTA-α-Lys-OctreotidePSMA-617
1414
1515151616
5
CUSTOM PEPTIDE SYNTHESIS
CHEMICAL SYNTHESIS
ANALYTICAL RESEARCH SERVISES
Pharm-Sintez.Lab is a leading company that has a substantial, long-standing expertise in custom peptide synthesis services, providing only high quality products for even complex or unusual peptide sequences. We apply only latest technologies and methods for peptide synthesis, and each purified peptide is analysed using a variety of different methods:
HPLC / UHPLC / GC / LC-MS
We are able to successfully synthesise both small amount of peptides (e.g. 10 or 25 mg), as well as larger amount (up to 100 gm). Additionally, we are capable to perform peptide synthesis of all stages, including: solid phase peptide synthesis, small molecular synthesis and high throughput synthesis. Our technologies allow us to deliver high quality peptide synthesis with a success rate more than 90%.
Pharm-Sintez.Lab has a long history offering successful peptide synthesis services to our customers. Our expertise will be able to answer all of your questions at any time of the process. As we pay close attention to the quality of our work, the control data, product characteristics and certificate of synthesis will always be provided to you.
Our advanced technical facilities allow us to perform complex multi-step organic and inorganic syntheses, offering our customers a wide range of compounds. We are able to produce compounds of all stages of chemical syntheses, including target and reference compounds, specialized reagents, combinatorial building blocks, and many other.
The quality of our products meets high international standards and is confirmed by established of quality control analyses:
HPLC / UHPLC / GC / LC-MS / NMR / IR / Polarimetry
We offer a wide range of established techniques for peptide and small molecule analyses. Our methods of analyses:
PHLC / UHPLC / GC / LC-MS / NMR Spectrophotometry / polarimetry / viscometry / laser diffractometry / titration
Apart from standard analytical methods our qualified specialists are experts in radiopharmaceuticals, which allows us to conduct research and evaluation of radiopharmaceuticals that are based on different radionuclides: 68Ga, 99mTc, 111In, 177Lu, 188Re. With our qualification, extensive knowledge of regulating policies and standards, qualified experts in chemistry, physics and microbiology, we guarantee our customers high quality performance.
Our strong reputation and long-term cooperation with local and international pharmaceutical industries and research institutions makes Pharm-Sintez.Lab a leading chemistry-based company offering a wide range of services.
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Application: Treatment of pleural mesothelioma and non-small cell lung cancer
Application: Treatment of infections caused by Gram-positive bacteria
Application: Multiple sclerosis
Chemical Formula: C20H33N5Na2O13
Chemical Name: Pemetrexed Disodium HeptahydrateFW(weight): 597.486CAS Number: 150399-23-8Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
Chemical Formula: C16H20FN3O4
Chemical Name: LinezolidFW(weight): 337.351CAS Number: 1658000-03-3Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
Chemical Formula: C6H8O4
Chemical Name: Dimethyl fumarateFW(weight): 144.126CAS Number: 624-49-7Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[h-303]
[h-302]
[h-301]
PEMETREXED
LINEZOLID
DIMETHYL FUMARATE
CHEMICAL SUBSTABCES
H HO
ONa+
+
-
NaO
O
OO
O
H HO
H HO
H
H
HHHH
HOH HO
H HO
H HON
N N N
N
F
HN
N
N
O
O
O
O
H
H
O
O
O
O
7
Application: Treatment of Prinzmetal’s angina and severe high blood pressure
Chemical Formula: C17H18N2O6
Chemical Name: NifedipineFW(weight): 346.339CAS Number: 21829-25-4Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[h-306]NIFEDIPINE
Application: Treatment of primary kidney cancer
Chemical Formula: C13H13N303
Chemical Name: LenalidomidFW(weight): 259.265CAS Number: 191732-72-6Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[h-305]LENALIDOMID
Application: Treatment of primary kidney cancer and liver cancer
Chemical Formula: C28H24CIF3N406SChemical Name: Sofarenib tosylateFW(weight): 637.027CAS Number: 475207-59-1Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[h-304]SORAFENIB TOSYLATE
CHEMICAL SUBSTABCES
N
O
O
O
O
O
O
N
H
+
–
O
O
O
H H
H
H
N
N
N
O
O
O
OS
Cl
F
F
F
O
O
HN
N
N
N
H
H
H
8
Application: Treatment of essential hypertension
[h-309]Chemical Formula: C9H12CIN50Chemical Name: MoxonidineFW(weight): 241.68CAS Number: 75438-57-2Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
MOXONIDINE
Application: Treatment of brain cancer, astrocytoma and glioblastoma
Chemical Formula: C6H6N6O2
Chemical Name: TemozolomideFW(weight): 194.154CAS Number: 85622-93-1Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[h-308]TEMOZOLOMIDE
Application: Preventing a major complication of subarachnoid hemorrhage
Chemical Formula: C21H26N2O7
Chemical Name: NimodipineFW(weight): 418.446CAS Number: 66085-59-4Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[h-307]NIMODIPINE
CHEMICAL SUBSTABCES
N
NN
N N
O
H
H
Cl
N
NN
N
N
N
O
O H
H
H
NH
O+
–
O
O
O
O
OO
9
Application: Treatment of cancer
Chemical Formula: C19H25BN404
Chemical Name: Bortezomib trimeric boroxineFW(weight): 284.243CAS Number: 179324-69-7Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
BORTEZOMIB [h-312]
Application: Prevention and treatment of metastasis-associated skeletal fractures
Chemical Formula: C9H22NNaO7P2
Chemical Name: Ibandronate sodium saltFW(weight): 341.212CAS Number: 138844-81-2Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
IBANDRONIC ACID [h-311]
Application: Treatment of multiple sclerosis
[h-310]FINGOLIMOD
CHEMICAL SUBSTABCES
Chemical Formula: C19H34CINO2
Chemical Name: FingolimodFW(weight): 343.936CAS Number: 162359-56-0Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
Н Н
Н
Н
N
NN
N
O
O
O OB
H
H
H
H P
P
Na+
-
N
O
O
OO
OO
O
H
H HH
HCl
NO
O
10
[h-313]TAMSULOSINChemical Formula: C20H29C1N205SChemical Name: Tamsulosini hydrochloridumFW(weight): 444.971CAS Number: 106463-17-6Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
Application: Treatment of benign prostatic hyperplasia
ZOLEDRONIC ACID [h-314]Chemical Formula: C5H10N2O7P2
Chemical Name: Zoledronic acidFW(weight): 272.09CAS Number: 118072-93-8Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
Application: Treatment of osteoporosis and bone complications of cancer
[h-315]LETROZOLEChemical Formula: C17H11N5
Chemical Name: LetrozoleFW(weight): 285.31CAS Number: 112809-51-5Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
CHEMICAL SUBSTABCES
Application: Treatment of hormonally-responsive breast cancer
N
N
N
N
N
С
С
H
H
H
HH
N
O
PP
O
OO
O O
O
N
H
H
H
HN
N
O O
O
O
Cl
O
S
11
Application: Treatment of ovarian cancer, lung cancer and other forms of cancer
TOPOTECAN HYDROCHLORIDE [h-316]Chemical Formula: C23H24CIN3O5
Chemical Name: Topotecan HydrochlorideFW(weight): 457.911CAS Number: 119413-54-6Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
CHEMICAL SUBSTABCES
O
Cl H
H
H
N
N
N
О
О
О
О
12
Applicati on: Treatment of prostate cancer
Chemical Formula: C66H86N18015
Chemical Name: Triptorelin AcetateFW(weight): 1371.525CAS Number: 140194-24-7Purity: >97%Size: 1 mg / 10mg / 100mg / up to request
TRIPTORELIN [p-103]
Applicati on: Treatment of breast and prostate cancer
Chemical Formula: C59H84N18014
Chemical Name: Goserelin acetateFW(weight): 1269.433CAS Number: 65807-02-05Purity: >97%Size: 1 mg / 10mg / 100 mg / up to request
[p-102]GOSERELIN
Applicati on: Treatment of prostate cancer or breast cancer
Chemical Formula: C62H90N16015
Chemical Name: Buserelin AcetateFW(weight): 1299.499CAS Number: 57982-77-1Purity: >97%Size: 1 mg / 10mg / 100 mg / up to request
BUSERELIN [p-101]
PEPTIDES
H
H
HH
H
H
HH
H
H
H
H
H
H
H
H
H H
H
H
N
N
N
N
N
N
N
N
NN
N
NN
N
N
N
N
N
O
OO
OO
OOO
O
O
O
OO
O
NH
H H
H
H H
HH
H
H
H
HH H
H
HH
H
N
N
N
N
N
N
N
N
N
N
NN
NN
N
O
OO
O
O
O
O
O
O
O
O
O
OO
O
13
Application: Treatment of growth hormone producing tumors
Chemical Formula: C61H88N16014
Chemical Name: Leuprorelin AcetateFW(weight): 1269.437CAS Number: 74381-53-6Purity: >97%Size: 1 mg / 10mg / 100 mg / up to request
Application: Treatment of prostate cancer, breast cancer, endometriosis
[p-105]OCTREOTIDEChemical Formula: C49H66N10010S2
Chemical Name: OctreotideFW(weight): 1019.247CAS Number: 83150-76-9Purity: >97%Size: 1 mg / 10mg / 100 mg / up to request
[p-104]LEUPRORELIN
PEPTIDES
N H
H
H H H
H
H
H
H
H
H
H
H
H
H
HN
N
N
N
N
N
N
N
NN
N
N
N
N
N
O
OO
O
O
OO
O
O
O O O
H
H
H
H
H
H
H
HH
HH
H
HH
H
O
OO
OOO
O
O S SO
O
N
NN
N N
NN
N
N
N
14
OCREOTIDE IMPURITIES [f-402]
[f-401]BUSERELIN IMPURITIES
PHARMACEUTICAL IMPURITIES
HN
N
N
N
NN
N
N
N N
H
HH
H
H
H
H H
H
H
H
H
HHH
O
OO
OO
O
OO
OO
SS
H
HHH
H
HH
HHH
H
H
H
H
HH
N
N
N
NN
N
N
N
N
NN
N
N
O
O
O
OO
OO
O
O
O
O
O
14
15
Application: Diagnosis and therapy of neuroendocrine tumors
Chemical Formula: C62H93N15O19S2
Chemical Name: DOTA-ɛ-Lys-octreotideFW(weight): 1415.6Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[r-203]DOTA-ɛ-Lys-octreotide
Application: Chelator for 177Lu, 68Ga and мY
Chemical Formula: C28H52N4O8
Chemical Name: DOTA-tri-t-Bu-esterFW(weight): 572.74CAS Number: 137076-54-1Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[r-202]DOTA-tri-t-Bu-ester
Application: Diagnosis and therapy of neuroendocrine tumors
Chemical Formula: C65H92N14019S2
Chemical Name: DOTA-TATE (acetate)FW(weight): 1437.65CAS Number: 177943-89-4Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[r-201]DOTA-TATE
PET PERSECUSORS
Н
N N
NN
O
O
O O
O
O OO
NN N
N
N
N
N N
N
N
N
N
N
N
N
HH
HH
H
H
H H
H
H
H
H
H
H
H
H
H
H
H O
O OO
O
O
O
O
O
O
O
O
O
O
O
O
OO O
SS
H HH
H
H
H
H H
H
HH
H
H
H
H
HH
H
NN N
N
N
N
N
NN
N
N
NN
N
O
O OO
OO
O
O
O
O
O
O
O
O
O
O
OO O
SS
16
Application: Diagnosis and therapy of prostate cancer
Chemical Formula: C49H71N9O16
Chemical Name: PSMA-617FW(weight): 1042.1CAS Number: NoPurity: >98%Size: 1 mg / 10mg / 100 mg / up to request
PSMA-617 [r-205]
Application: Diagnosis and therapy of neuroendocrine tumors
Chemical Formula: C62H93N15O19S2
Chemical Name: DOTA-α-Lys-octreotideFW(weight): 1415.6Purity: >98%Size: 1 mg / 10mg / 100 mg / up to request
[r-204]DOTA-α-Lys-octreotide
PET PERSECUSORS
H
H
H H
H
H
H
HN
N
N
N
N
N N
NN
O
OO
O
O
O
OO
O
O
O OO –
–
O
O
O
NN N
N
N
N
N N
N
N
N
N
N
N
N
HH
HH
H
H
H H
H
H
H
H
H
H
H
H
H
H
H O
O OO
O
O
O
O
O
O
O
O
O
O
O
O
OO O
SS
17
ON-LINE CATALOG: www.labphs.com
Pharm-Sintez.Lab is a leading innovative company in the field of nuclear medicine,product development, custom peptide synthesis and chemical pharmaceutical tecnologies.
– Chemical substances– Peptides– Radiopharmaceuticals (kits)– PET Precursors– Pharmaceutical impurities
17
18
NOTES
19
NOTES