OrganicOrganicNon-linear OpticNon-linear Optic
MaterialsMaterials
A novel technology in Physics, Chemistry, Biology, A novel technology in Physics, Chemistry, Biology, Medicine, Material, Micro-electronics, and so on…Medicine, Material, Micro-electronics, and so on…
Duan Xiaofei2005-9-30
2μm2μm
IntroductionIntroductionTPA (two-photon absorption)TPA (two-photon absorption)SHG (second harmonic generation)SHG (second harmonic generation)
ApplicationApplicationMPM (Multi-photon microscopy)MPM (Multi-photon microscopy)TPIP (two-photon-initiated polymerization)TPIP (two-photon-initiated polymerization)Novel TPA Materials & Future ApplicationNovel TPA Materials & Future Application
ConclusionConclusion
OverviewOverview
IntroductionIntroductionTPA (two-photon absorption)TPA (two-photon absorption)SHG (second harmonic generation)SHG (second harmonic generation)
ApplicationApplicationMPM (Multi-photon microscopy)MPM (Multi-photon microscopy)TPIP (two-photon-initiated polymerization)TPIP (two-photon-initiated polymerization)Novel TPA Materials & Future ApplicationNovel TPA Materials & Future Application
ConclusionConclusion
OverviewOverview
Introduction: PhysicsIntroduction: Physics
光克尔效应、四波混频、二次谐波、双光子吸收
Introduction: PhysicsIntroduction: Physics
Introduction: TimelineIntroduction: Timeline
1930Goppert-Mayer
Ann.Physik,1931,9,273~2951960
KaiserPhys.Rev.Lett,1961,39,1347~1348 1990
Denk: MPM
Organic TPA1995
Physics, Biology, Physics, Biology, Chemistry, Medicine, Chemistry, Medicine,
Material, Material, Micro-electronicsMicro-electronics
Introduction: TPAIntroduction: TPA
Introduction: TPAIntroduction: TPA
Introduction: TPAIntroduction: TPA
Introduction: SHGIntroduction: SHG
IntroductionIntroductionTPA (two-photon absorption)TPA (two-photon absorption)SHG (second harmonic generation)SHG (second harmonic generation)
ApplicationApplicationMPM (Multi-photon microscopy)MPM (Multi-photon microscopy)TPIP (two-photon-initiated polymerization)TPIP (two-photon-initiated polymerization)Novel TPA Materials & Future ApplicationNovel TPA Materials & Future Application
ConclusionConclusion
OverviewOverview
MPM From Prof. W. W. WebbMPM From Prof. W. W. Webb
MPMMPM
Webb, W. W. Science 1997, 275, 530
Amine
Live cell
MPM: NADHMPM: NADH
N
H H
NH2
O
R
NADH
N
H
NH2
O
R
+ H+ + 2e-
NAD+
MPM: NADHMPM: NADH
MPM: BrainMPM: Brain
MPM: HeartMPM: Heart
MPM: LungMPM: Lung
MPM: LiverMPM: Liver
Cahalan, C Science 2002 296 1869
LymphocyteLymphocyte
Germain T. Science 2002 296 1873
Cell DivisionCell Division
MPM: PlantsMPM: Plants
Cancer
Bowel disease
Alzheimer's Disease
MPM: DiseasesMPM: Diseases
MPM From INOMPM From INO
MPM From INOMPM From INO
IntroductionIntroductionTPA (two-photon absorption)TPA (two-photon absorption)SHG (second harmonic generation)SHG (second harmonic generation)
ApplicationApplicationMPM (Multi-photon microscopy)MPM (Multi-photon microscopy)TPIP (two-photon-initiated polymerization)TPIP (two-photon-initiated polymerization)Novel TPA Materials & Future ApplicationNovel TPA Materials & Future Application
ConclusionConclusion
OverviewOverview
TPATPA
TPIPTPIP
Perry, J. W.; Marder, S. R.; Qin, J. G. Nature 1999, 398, 51
N
N
O
O
TPIPTPIP
Kawata, S. Nature 2001, 412, 697
TPIPTPIP
2μm
2μm
TPIPTPIP
Kawata, S. Nature 2001, 412, 697
TPIPTPIP
Gong, Q. H. Chem. Phys. Lett. 2003, 374
TPIPTPIP
IntroductionIntroductionTPA (two-photon absorption)TPA (two-photon absorption)SHG (second harmonic generation)SHG (second harmonic generation)
ApplicationApplicationMPM (Multi-photon microscopy)MPM (Multi-photon microscopy)TPIP (two-photon-initiated polymerization)TPIP (two-photon-initiated polymerization)Novel TPA Materials & Future ApplicationNovel TPA Materials & Future Application
ConclusionConclusion
OverviewOverview
Webb’s modelWebb’s model
Webb, W. W. Science 1998, 281, 1653
Webb, W. W. Science 1998, 281, 1653
Webb’s modelWebb’s model
Barlow, S. J. Am. Chem. Soc 2005, 127, 10844
Webb’s modelWebb’s model
Marder, S. R. J. Am. Chem. Soc 2005, 127, 7282
Webb’s modelWebb’s model
D-D`-A`-AD-D`-A`-A
Bazan, G. C. J. Am. Chem. Soc 2005, 127, 7282
Webb’s modelWebb’s model
Frechet, J. M. J. Chem. Mater., 2000, 12, 2838
Dendritic Dendritic
Frechet, J. M. J. Chem. Mater., 2000, 12, 2838
Dendritic Dendritic
Goodson, III T. J. Am. Chem. Soc 2005, 127, 10128
Dendritic Dendritic
Kobuke, Y. J. Am. Chem. Soc 2003, 125, 13356
Self-Assembly Self-Assembly
Osuka, A. J. Am. Chem. Soc 2005, 127, 535
Self-Assembly Self-Assembly
Osuka, A. J. Am. Chem. Soc 2005, 127, 535
Self-Assembly Self-Assembly
Charndrashekar, T. K. J. Am. Chem. Soc 2005, 127, 11608
HeteroatomsHeteroatoms
FRET Enhanced TPA FRET Enhanced TPA
Frechet, J. M. J. J. Am. Chem. Soc. 2003, 125, 1448
Frechet, J. M. J. J. Am. Chem. Soc. 2003, 125, 1448
FRET Enhanced TPA FRET Enhanced TPA
Singlet OxygenSinglet Oxygen
Frechet J. M. J. J. Am. Chem. Soc. 2004, 126, 5380
Frechet J. M. J. J. Am. Chem. Soc. 2004, 126, 5380
Singlet OxygenSinglet Oxygen
Frechet J. M. J. J. Am. Chem. Soc. 2004, 126, 5380
Singlet OxygenSinglet Oxygen
Frechet J. M. J. J. Am. Chem. Soc. 2004, 126, 5380
Singlet OxygenSinglet Oxygen
NO Photochemical ProductionNO Photochemical Production
Ford, P. C. J. Am. Chem. Soc. 2004, 126, 13566
NO Photochemical ProductionNO Photochemical Production
Ford, P. C. J. Am. Chem. Soc. 2004, 126, 13566
NO Photochemical ProductionNO Photochemical Production
Ford, P. C. J. Am. Chem. Soc. 2004, 126, 13566
Wolf RearrangementWolf Rearrangement
Ford, P. C. J. Am. Chem. Soc. 2004, 126, 13566
Wolf RearrangementWolf Rearrangement
Ford, P. C. J. Am. Chem. Soc. 2004, 126, 13566
Hruby, V. J. J. Am. Chem. Soc. 2004, 126, 7160
Bio-labelBio-label
Hruby, V. J. J. Am. Chem. Soc. 2004, 126, 7160
Bio-labelBio-label
IntroductionIntroductionTPA (two-photon absorption)TPA (two-photon absorption)SHG (second harmonic generation)SHG (second harmonic generation)
ApplicationApplicationMPM (Multi-photon microscopy)MPM (Multi-photon microscopy)TPIP (two-photon-initiated polymerization)TPIP (two-photon-initiated polymerization)Novel TPA Materials & Future ApplicationNovel TPA Materials & Future Application
ConclusionConclusion
OverviewOverview
ConclusionConclusion
Chemistry Physics
MedicineBiology
Engineering
NovelMaterials
NovelMaterials
AcknowledgeAcknowledge
Thanks for Prof. Pei and All Prof. & Ph.D candidates
in Organic Institute !!!
Thank you for your attention !Thank you for your attention !