PLANT RESPONSE BIOTECH S.L.
- R+D Biotechnology company - Spin-off from the Biotecnología Department/Centro de Biotecnología y Genómica de Plantas (CBGP) of the Universidad Politécnica de Madrid.
Mission and vision
- Transfer excellence science results to the farmers -Answer plant protection and breeding market needs developing new technologies compatible with intensive, integrated and ecological Agriculture
-Reduce agriculture’s environmental impact and improve our quality of life with healthier food without residues
PlantResponse
PlantResponse
Organization
Board of directors Scientific advisory board
Dr. John Ryals Metabolon Inc, Research Triangle Park, North
Carolina, USA
Dra. Salome Prat Research Professor, CNB-CSIC, Madrid, Spain
Dr. Dierk Sheel Director Leibniz Institute of Plant Biochemistry
(IPB), Halle, Germany
Management team
Collaborations Thorsten Nürnberger , Jürg Felix, Frederik Brunner, Andrea Gust (EKUTübingen) Ivo Feussner (University of Götinguen) Cyril Zypfel (The Sainsbury Laboratory in Norwich) Julio Salinas (CIB-CSIC)
Co- founder
Dr. Antonio
Molina
CEO
Eduardo Quemada
R&d Head Manager
Dr. Marisé
Borja
New technologies (Know-how and Patents) to control biotic or abiotic stress in plants, are
developed in collaboration through licence with Research Centers or companies to bring the following
products to the market:
* “New stimulators/elicitors” activating plant innate immunity in plants from:
- Natural sources: microorganism or plant derived molecules
- Chemical sinthesis: Chemetics (Chemical Genetics) identification
* Plant metabolites activating plant stress resistance
* Plant Genes coding for the proteines involved in the elicitor recognition, plant stress signaling or
down stream components to breed new plant varieties resistant to biotic and abiotic stresses by:
- Classical breeding (horticultural species)
- Biotechnology(GMOs for extensive crops corn, soy bean, potato,.. )
Plant Response Biotech Technologies and Products
MAMP/ELICITORS
RLK
Immune Response and Resistance to Pathogens
RLK
RLK
Plant Cell
Pathogens
PK
PK
TIR
PK
(PRRs)
K
LRR
DROSOPHILA
TOLL LR
R
TIR
MAMMALS
TLR4
LBP
LR
R
CD14
PLANTS
Xa21
K
LR
R
FLS2
K
LR
R
RPS5
BAK1
K
EFR
K
LR
R
MAMPs
flg22 Spätzle
PGN
LPS elf18
LR
R
NBS
LR
R
NBS CC
TIR
RPS4
LRR
NB
S
Avr
PphB
Avr
Xa21
Avr
Rps4
Effectors
TIR
PBS1
IMMUNE RESPONSE GENES
ANTIMICROBIAL PEPTIDES and PR (plant defence-related) proteins
Dif/
Relish
Cactus
TFs
(WRKYs/TGAs) NF-kB
IkB
MYD88 PK Tube PK
IRAK
MAPKs PK
PK
K
PK
KK
PK
PK
K
PK
KK
PK
PK
K
PK
KK
Pelle
MEKK1
MEK1/MKK2
MPK4
MEKK?
MKK4/MKK5
MPK3/MPK6
PlantResponse
Plant Innate immunity applied to biotic stress response
Tena et al, 2011
Plant Innate immunity applied to biotic stress response
High throughput screening for conserved responses High throughput screening
Tena et al, 2011
Plant Innate immunity applied to biotic stress response
High throughput screening for early responses
PlantResponse
Garlic field trials: 10-20% production increase
PBR1 product development
0
20
40
60
80
100
120
CONTROL Product A Product B PRB1 2g/l PRB1 4g/l CONTROL PRB1 2g/l PRB1 4g/l
Wei
gh
t (g
ram
s)
Treatment
Fresh weight 2012
0
10
20
30
40
50
60
CONTROL
(PRELUDE)
PRB1
(2g/L)
PRB1
(4g/L)
Product C
(Bion min)
Product C
(Bion max)
Dry weight 2009)
Pepper greenhouse trials: 10-20% production increase
PBR1 product development
0
2
4
6
8
10
12
14
ORIUS
SWIRSKII
It does not affect biological control insects and production is 1 month earlier
Kil
ogra
ms/
trea
tmen
t
PRB1 Product Development
Organic onion production: 20-30% production increase
*
*
We
igh
t
PBR1 TREATMENT
MEANS and Fisher 95% LSD
QUALITY CONTROL: The company has done extensive formulation
and quality control validation trials since there is a big variability among
different sources and formulations. Extensive data are available for the
PRODUCT REGISTRATION.
PlantResponse
Product Development QUALITY CONTROL
0
200
400
600
800
1000
1200
1400
0 7…
1…
2…
2…
3…
4…
4…
5…
6…
7…
7…
8…
RL
U
PBR3 ESP 10mM
Aequo
Col 0
Aequo+H2O
0
200
400
600
800
1000
1200
1400
0
68
138
210
282
354
426
498
570
642
714
786
858
RL
U
PBR3 AS12 50mM
CROPS STRESS
Tomato Pepper Melon Potato Rice Canola Citrus Grapevine Strawberry Ornamental
Xanthomonas axonopodis pv. citri
X X X
Sclerotinia sclerotiorum X
Phytophthora infestans X
Fusarium oxysporum X X
Botrytis cinerea X X X X X
Magnaporte oryzae X
Rhizoctonia solani X X X X X
Rhizopus oryzae X
Ralstonia solanacearum X X X
Drought X X X X
Salinity X X X X X
Frost X X X X X
Plant stress response Current Targets
X: ongoing X: planned