Polysaccharide Aa widely distributed immunoregulatory microbial product

Matthew Rhodes and Catherine LozuponeUniversity of Colorado, Denver

Rocky Mountain Bioinformatics Conference

December 11th 2014

Mazmanian and Kasper 2006

Mazmanian 2009

The Microbial Health Factor (PSA)

One bacterial molecule sufficient to mediate healthy immune response!!!

BAD GOODPSA

The B. fragilis PSA Operon

Coyne et al. 2001

E-ValueH

its to

wcf

RNext best hit in B. fragilis (PSB)

IL-10 Production Amongst PSA Producers

Red: PSA Black:No-PSA

0

200

400

600

IL-1

0 (p

g/m

l)

Neff unpublished

PSA and HIV

Erysipelotrichales and HIV OTUs

Red: Genome without PSAOrange: OTU up with HIVGreen: Genome with PSABlue: OTU down with HIV

Thank You!!!Lozupone LabPalmer LabSarkis Mazmanian and other CollaboratorsComputational Bioscience for Funding