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...Catc
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tt dododottthahahannn by thoby thoby those
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BroBroBroncncnchihihial Astal Astal Asthmhmhma
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04/13/04/13/04/13/090909
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Asthma-Pathology -3
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phphyyysssioioiololologggy ofy ofy of
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memennntttfffooor br br br
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Asthma-Pathology -4
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gg ouououttt ooofffPhPhPhilip
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Asthma-Pathology -5
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TTThhheee coucoucoughghgh wawawasss prodprodproducucuctivtivtiveee w
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tthehehe tttimeimeime ooofff ttthe
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aa tttime.ime.ime. SheSheShe wawawasss fffeelin
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frofrommm ttthehehe nosenosenoseaaandndnd cra
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Asthma-Pathology -6
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disdisttturbedurbedurbed dueduedue tttooo ttthe
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Asthma-Pathology -7
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Asthma-Pathology -8
AsAsAsthm
thmthmaaa:::
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oovavavariousriousrious stststimulimulimuli (i (i (a
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Asthma-Pathology -9
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ouou cancancan cccaaatchtchtch asthmaasthmaasthma f
ffrororommm sososomeomeomeonnneee elseelseelse wwwhohohohahahas
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wwithithith aaasssthmathmathma ssshhho
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SomeSomeSomeone wone wone withithith aaast
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.
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Asthma-Pathology -10Shashi04/13/0904/13/09Percent Change in Age-Percent Change in Age-Adjusted Death Rates, U.S.,Adjusted Death Rates, U.S.,1965-19981965-19980
0.51.01.52.02.53.0Proportion of 1965 Rate1965 -1998 1965 -1998 1965 -1998 1965 -1998 1965 -199859% 64% 35% +163% 7%CoronaryHeartDiseaseStroke Other CVD COPD All Other
CausesPercent Change in Age-Percent Change in Age-Adjusted Death Rates, U.S.,Adjusted Death Rates, U.S.,1965-19981965-199800.51.01.52.02.53.0Proportion of 1965 Rate1965 -1998 1965 -1998 1965 -1998 1965 -1998 1965 -1998
59% 64% 35% +163% 7%CoronaryHeartDiseaseStroke Other CVD COPD All OtherCauses
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Asthma-Pathology -11
Anatomy PhysiologyAnatomy Physiology04/13/04/13/04/13/09
0909
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Asthma-Pathology -12
.
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eelululungsngsngs, t, t, togeogeogether witther witther with
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ee cccellsellsells and pand pand pickickickuuup
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Asthma-Pathology -13
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oo ttthehehe lu
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lulunnngggsss sssooot
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thethe bbbooodydydy aaannndddcccarboarboarbonnn dioxiddioxiddioxideee ca
cacannn bbbeee exhaleexhaleexhaled.d.d. DDDuuurinrinringggbrebrebreatatathhhing,ing,ing, airairair papapasssssseeesss fffrororommm ttthhhe
ee nnnooos
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sseee aaannndddmmmo
oouthuthuth ininintttooo ttthhheee ppphhhaaarrry
yynnnxxx aaannnddd ttthhhrororoughughugh ttthhheee
larylarylarynnnxxx ininintttooo thethethe tttracracrachhheeea.a.a. TTThehehe tttrachearachearacheabifbifbifurururcccatatateseses tttooo c
ccarryarryarry aaair
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irir intintintooo eaceaceachhh lunlunlunggg.
..TTThhheeesesese tttwwwooo tttuuubbbes
eses aaarrreee ttthhheee mmmainainain ssstttememembron
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ininggglelele right
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rightright mamamaiiinnn ssstttememem
Shashi
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thethe leleleftftft anananddd rightrightright lunlunlungggs,s,s,
ively.
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Asthma-Pathology -14
AnAnAnatom
atomatomyyy anananddd PPPhhhyyysiolsiolsiologogogyyy
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Asthma-Pathology -15
AsthmaAsthma04/13/04/13/04/13/09
0909
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Asthma-Pathology -1604/13/09 ShashiINFLAMMATIONAirflow LimitationSYMPTOMSCough Wheeze
DyspneaTRIGGERSAllergens, Exercise,Cold Air, SO2 ParticulatesPathophysiology:AirwayHyperresponsivenessGenetic*INDUCERSAllergens,Chemical sensitizers,Air pollutants, Virus infections
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Asthma-P holog 1704/13/09 ShashiPredisposing Factor.Atopy.Female genderCausal Factors
>Exposure to indoorAnd outdoor allergens>OccupationalsensitizersContributing Factors>Respriratory infections>Air pollution>Active/passive smoking>Others diet, small sizeat birthInflammationHyperresponsiveness
of airways Airflow limitationRisk Factors forExacerbations.Allergens.Respiratory infections.Exercise and hyperventilation.Weather changes.Exposure to sulfur dioxide.Exposure to food, additives,medicationsSymptoms.Wheezing.Cough
.Dyspnea
.Chest tightness
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Asthma-Pathology -18
PathPathPathogogoge
eennnesesesiiisss - A- A- AtttooopicpicpicAsAsAsthmthmthma
aa:::04/13/04/13/04/13/090909
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Asthma-Pathology -19
MasMasMast ct ct cells
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ss:::
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Asthma-Pathology -20
EEEooos
ssinophiinophiinophilslsls ininin AAAsssthmathmathmaPatPatPathohohogggeeen
nneeesssiiisss:::
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Asthma-Pathology -21
Lung Morphology in AsthmaLung Morphology in Asthma.Bro
BroBronchialnchialnchialinflainflainflammmmmmatatationionion
.
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.
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elecelectttasasasisisis.CCCOPD
OPDOPD
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Asthma-Pathology -22
LunLunLung
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mmaaa
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Asthma-Pathology -23
ThThThick bick bick br
rroooncncnchhhiii withwithwith MMMuuucoucoucoussspppl
lluuugggsss
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Asthma-Pathology -24Shashi04/13/0904/13/09Asthma MicroscopicAsthma MicroscopicPathologyPathologyObstructedInflammed
Bronchi
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Asthma-Pathology -25
AsAsAsttthm
hmhma - Bra - Bra - Brooonchialnchialnchial morpmorpmorphohoholllooogggyyy
.inininffflalalammmmmmatatatioioionnn.
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luluggg inininlululummmenenen
.
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uussscleclecle laylaylayererer
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Asthma-Pathology -26
AsAsAst
tthmhmhma - Bra - Bra - Brooonchialnchialnchial morpmorpmorphohoholllooogggyyy
InflaInflaInflammmmatmatmatioioio
nnnMMMucoucoucousususPlu
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.04/13/04/13/04/13/090909
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Asthma-Pathology -27
AsAsAst
tthmhmhma Ta Ta THHH2 l2 l2 lyyympmpmphohohocycycytetetesssiiimm
mmmmunounounossstttaiaiainingningning)))
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Asthma-Pathology -28
MuMuMuc
ccououous ps ps pllluuuggg ininin aaasthsthsthmmma:a:a:
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Asthma-Pathology -29
EEEosin
osinosinopopophilhilhilsss iiinnn AsthAsthAsthmmma:a:a:
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Asthma-Pathology -30
MedMedMedical Man
ical Manical Managagagemememenenenttt
TheTheTherrreee areareare twotwotwo b
bbasasasic kindic kindic kindsss ooofffmmmeeedddicatioicatioication fon fon forrr t
tthehehe tretretreatmeatmeatmentntnt ofofofasasasthma:thma:thma:
.LonLonLong-g-g-teteterm crm crm cononontttrolrolrolmedimedimedicatcatcatiiionononsss
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icickkk rrrelielielief (ef (ef (rereresssc
ccue)ue)ue)medimedimedicatcatcatiiionononsss
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Asthma-Pathology -31
LLLongongong-term
-term-term cococontrolntrolntrolmmmedicedicedicatioatioationsnsns
.
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-----useuseuseddd ooonnn aaa rereregggulululararar bbbasisasisasis t
ttooo prepreprevevevennnttt aaattttactactacksksks,,, nnnoootttfffooor trr trr treaeaeatttmentmentment duringduringduring ananan attattattaaack.ck.ck.
.
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inhinhinhalalaleeeddd stersterstero
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AccoAccolllate)ate)ate)
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oorrr nnneeedddooocrcrcromil
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nti-infnti-inflalalammammammatttororory ay ay andndndbro
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Asthma-Pathology -32
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Shashi
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Asthma-Pathology -33
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ffirlukirlukirlukaaasssttt --- iiinhibi
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Asthma-Pathology -34ArachidonicAcidLeukotrienesCyclooxygenas5-LipoxygenaseProstaglandins
Cell DamageCell MembranePhospholipids SteroidsNSAIDProstacyclins
LTC4, D4, E4
5-LO inhibitorsAntileukotrienes
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Shashi
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Asthma-Pathology -35
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.PPProroropppererer manmanmanagemeagemeagementntnt ... normnormnormalalal
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ThThThananankkk YYYooou
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Nia Alma M. Bianson RNLyceum of the Philippines UniversityBatangas City
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Asthma-Pathology -37
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.
BBBererertototo,,, J.MJ.MJ.M...;;; PelaPelaPelaeeez,z,z, A.A.A.;;; Fer
FerFernnnananandez
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dezdez EEE;;; AAA newnewnew indindindoooo
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NaNadeldeldel JA,JA,JA, eeeds.ds.ds. TTTextextextb
bbooooookkk ofofof RespiratoRespiratoRespiratoryryryMedMedMedicineicineicine... VoVoVol.l.l. 1,
1,1, 333rdrdrd ed.ed.ed. PhilPhilPhiladadadeeelplplphihihia,a,a, Pa.Pa.Pa.::: W.W.W.B
BB...SaSaSaunununderderders;s;s; 2020200000.0.0.
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ShShShieieierrr DDD,,, BBBuuutletletlerrr JJJ,
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ss R.R.R. HoHoHollleee's Hu's Hu's Humamaman
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www.w.w.aaallre
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llrellrefffererer...cococommm Shashi
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