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Page 1: Pulmonary hypertension and anesthesia

PULMONARY HYPERTENSION & ANESTHESIA

Dr. wesam farid MousaDr. Salwa hassan khalil

Anesthesia & Surgical ICU DepartmentFaculty of Medicine

Tanta University

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Definition. Classification. Pathogenesis. Diagnosis and treatment of PH. Peri-operative management of PH crisis.

PH in special situations..

objectives

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Pulmonary circulation is a high flow, low resistance circuit capable of accommodating the entire right ventricular output at one-fifth the pressure of the systemic circulation.

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DEFINITION

PH is defined as a mean pulmonary artery pressure greater than 25 mmHg at rest based upon right heart catheterization measurements . A mean pulmonary artery pressure of 8 to 20 mmHg at rest is considered normal,.

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RV enlargement secondary to any

underlying cardiac or pulmonary disease.

Pulmonary hypertension is the most common cause of cor pulmonale.

Cor pulmonale

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An estimated 15 to 52 people in 1 million have PAH world wide.Armin Sablotzki1, Hans-Juergen SeyfarthJochen Gille1, Stefan Gerlach1, Michael Malcharek1 and Elke Czeslick.Critical Care and Pain Medicine, Klinikum St. Georg gGmbH,Germany Department of Pneumology, Universitätsklinikum Leipzig AöR, Germany Clinic for Anesthesiology and Critical Care Medicine, Martin-Luther-University of Halle-Wittenberg, Germany2015

Epidemiology

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CLASSIFICATION

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A distinction between pre-capillary and post capillary PH is

fundamental to understand the vascular and hemodynamic changes present in

patients with PH.

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VC RA RV PA PVPC

LA LV Ao

Post-Capillary PH (PCWP>15 mmHg; PVR nl)

Systemic HTNAoV Disease

Myocardial DiseaseDCM,HCM,ischemic

CMRCM,Obesity ,

others

Atrial MyxomaCor Triatriatum

PV compression

PVOD

PAHRespiratory

DiseasesPE

Pulmonary Hypertension: Define Lesion

MV Disease

LVEDP

Pre-capillary PH

PCWP<15 mmHgPVR > 3 Wu

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CLASIFICATION

Mean PAP (mmHg)

25 - 4041 - 55

>55

Degree of disease

MildModerateSevere

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NORMAL REVERSIBLE DISEASE IRREVERSIBLE DISEASE

Pathogenesis of Pulmonary ArterialHypertension

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DIAGNOSIS OF PH

Symptoms of PH

Dyspnea 60% Fatigue 19% Near syncope/syncope 13% Chest pain 7% Palpitations 5% Leg edema 3%

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PHYSICAL EXAMINATION Loud pulmonary component of the 2nd heart

sound P2 (increases PAP) Left parasternal lift (RV heave=R sided

overload) Systolic ejection murmur of TR S3 gallop (advanced RV failure) Signs of RV failure: Jugular venous distention Hepatomegaly Perepheral edema

CLEAR LUNGS

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INVESTIGATIONS:

Right heart catheterization is the gold standard to confirm the diagnosis and establish the severity of PH .

Transthoracic echocardiogram (TTE) remains the method of choice for screening and assessing the PH when clinically suspected.

Once the diagnosis is confirmed, other diagnostic tools assist in establishing the underlying etiology and clinical group to which the patient belongs.

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Diagnosis Associated conditionEchocardiography Left ventricular systolic and diastolic dysfunction

Left-sided valvular heart disease CHD with systemic to pulmonary

shunt

X-ray chest, PFT COPD, sarcoidosis Interstitial pulmonary fibrosis

V̇/Q̇ scan, CTPA Chronic thromboembolic pulmonary disease

Sleep study Obstructive sleep apnoeaSerological test

(ANA, HIV )Lupus, scleroderma, HIVLiver ultrasound Portopulmonary hypertensionRight heart Catheterisation CHD with systemic to pulmonary shunt

Postcapillary PH due to left heart

disease Cardiac MRI CHD, cardiomyopathiesOver night Oxymetry PH with OSAH

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ALGORITHM FOR INVESTIGATION OF SUSPECTED PH

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TREATMENT OF PHGoals of Therapy

Alleviate symptoms, improve exercise capacity and quality of life

Improve cardiopulmonary hemodynamics and prevent right heart failure

Delay time to clinical worsening

morbidity and mortality

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TERAPUTIC TARGETS FOR PH

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ANESTHETIC MANAGEMENT OF PH.

PH is a serious condition.perioperative mortality of 7-24%.

Peri-operative morbidity 14–42% includes: Respiratory failure Heart failure, dysrhythmias Sepsis, Renal insufficiency, Myocardial infarction.

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pre-operative evaluation:

Multidisciplinary team anesthetists, surgeons, pulmonologists, and cardiologists.

Patients ‘suspected’ of having PH and ungraded severity are at higher risk of peri-operative complications.

Elective surgery must be postponed till a proper pre-op evaluation & optimization.

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pre-operative evaluation:

Patient with established PH should be based on a risk assessment :

functional state severity of the disease type of surgery.

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WHO CLASSIFICATION OF FUNCTIONAL STATUS OF PATIENT WITH PH

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SIGNS OF DISEASE SEVERITY Dyspnea at rest ( WHO- FC class 4)

Low cardiac output with metabolic acidosis

Hypoxemia

Signs of right heart failure

Syncope (poor prognosis)

Chest pain (secondary to RV ischemia)

Rapid progression of symptoms

6 minute walking test <300m.

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PREOPERATIVE MANEGMENT

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pre-operative evaluation:

A detailed history and physical examination should be complemented with relevant investigations :

Laboratory tests, electrocardiography, chest radiography, arterial blood gas analysis, echocardiography,

recent right heart catheterization which is the gold standard for diagnosis of PH.

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PREOPERATIVE MANEGMENTIdeally before surgery, mean PAP should be reduced to a normal of 25 mm Hg.

If substantial RV dysfunction is present, the advisability of surgery should be reexamined.

Any chronic pulmonary hypertensive therapies that patients are currently taking should be continued perioperatively to avoid rebound PH

Short acting anticoagulant like heparin should replace indirect anticoagulant until the surgical procedure.

Avoid anxiety, pain, and sympathetic stimulation.

Avoid over sedation and hypoventilation.

Antibiotic prophylaxis must be given.

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INTRAOPERATIVE MANAGEMENT

Anesthetic and Hemodynamic goals for PH :

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ANESTHETIC CONSIDERATIONSIntraoperative “basic treatment” to avoid an increase of pulmonary arterial pressure: “Luxury”-oxygenation with inspiratory FiO2 0.6 – 1.0 Moderate hyperventilation (goal: PaCO2 30-35 mmHg) Avoidance of metabolic acidosis (pH > 7.4) Recruitment-manoeuver to avoid ventilation/perfusion-

mismatch. Low-tidal-volume ventilation to avoid over-inflation of aveoli

(goal: 6 ml/kg ideal body weight) Temperature management to maintain body temperature of

36-37 °C “Goal-directed” fluid- and volume-therapy with

hemodynamic monitoring

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INTRAOPERATIVE MANAGEMENT

Optimize RV function and CO with adequate preload, SVR, and avoid contractility, avoid myocardial depressants

Consider pulmonary vasodilators to decrease RV afterload

Maintain sinus rhythm.

It is good practice to remove air from intravenous syringesand lines

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MONITORINGThere is no strong evidence to suggest that any specific type of monitoring has an influence on patient morbidity and mortality. The standard monitoring is considered sufficient for minor & medium procedures in functional state 2.

All major interventions and those in functional state III should be carried out under extended monitoring.

Transesophageal echocardiography (TOE) .pulmonary artery catheter .

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MONITORINGInvasive arterial monitoring before anesthetic induction Early recognition of hemodynamic instability. Intermittent arterial blood gas sampling to check

adequacy of ventilation.

Right atrial pressure measurement (central venous pressure)reflects the relationship of blood volume to the capacity of the venous system and also reflects the functional capacity of the right ventricle.

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ANESTHETIC TECHNIQUES

All standard anesthetic techniques can, in principle applied to patients with

PH

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ANESTHETIC TECHNIQUESRegional anesthetic techniques: Not impairing spontaneous breathing postoperative analgesic therapy

Nearly all patients with pulmonary hypertension receive continuous anticoagulant therapy; this fact must be taken under.

In severe PH or in diseases affecting the lung, patients cannot be subjected to remaining in a flat position for long period of time.

Regional anesthesia combined with careful GA to ensure adequate oxygenation.

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GENERAL ANESTHESIAthe main advantages are

Safe oxygenation , uncomplicated airway management, and intraoperative selective pulmonary vasodilation can – if necessary – easily be administered through the breathing circuit.

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GENERAL ANESTHESIA

All standard induction anesthetics can be used in combination with opioids, as they have no influence on pulmonary vascular resistance and oxygenation.

Ketamine may PVR due to catecholamine effect. However patients with RV failure may be catecholamine depeleted.

Histamine-releasing muscle relaxants (atracurium , mivacurium) should be avoided for patients with PH, PVR.

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GENERAL ANESTHESIA

Volatile anesthetic agents of concentrations up to 1 MAC can be administered without any negative effects on pulmonary pressure and resistance.

Nitrous oxide better avoided as it may raise PVR.

So use balanced technique, mixing higher doses of opioids and low-dose volatile anesthetic agents ,careful with stress response during intubation.

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During Extubation:Maintaining haemodynamic stability and adequate ventilation can be difficult.

Deep extubation May decrease SVR, contractility Hypoxia and hypercarbia will increase PVR

Awake extubation Can cause severe pulmonary vasoconstriction Need tube tolerance without increased sympathetic

tone

Patient may need post-op ventilation with ICU admission

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postoperative monitoring until pulmonary pressures and right-sided heart functions have stabilized at the preoperative level.

sufficient analgesic therapy in the form of continuous regional anesthesia to avoids higher doses of opioid-based analgesics.

The specific therapy for PH should be resumed at the preoperative dosage as soon as possible.

In the postoperative course, it is also advisable to

treat pressure elevations.

POSTOPERATIVE MANEGMENT

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PERI-OPERATIVE MANAGEMENT OF PH CRISIS

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PULMONARY HYPERTENSION WITH LAPAROSCOPYPneumoperitoneum with CO2 causes an increase in end tidal carbon dioxide. Acidosis, arrhythmias ,decrease preload PH crisis.

post operative benefits of laparoscopic surgery must be balanced with intraoperative risk involved.

IAP to be maintained at 10-12 mm of Hg.

CO2 insufflation slow rate to attenuate abdominal stretch response Temporarily deflate the abdomen if necessary.

Combined general with epidural anaesthesia decreasing intraoperative anaesthetic requirement. post operative pain relief.

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PULMONARY HYPERTENSION WITH PREGNANCY

Mortality rate of 30% in patients with idiopathic PAH and 56% in patients with PH associated with other conditions.

GA associated with a four-fold increase in maternal mortality

Physiological increase in blood volume causes volume overload in the right heart may cause: thromboembolic events. cerebrovascular accidents.

General principals for high risk parturient.

Left lat. Position .

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Fetal monitoring as IUGR due to hypoxemia and increased Hct level.

Anticoagulation is usually recommended. LMWH.

Warfarin and Endothelin receptor antagonists are avoided due to potential teratogenicity.

Elective CS before 32 Ws allows for better planning, a multidisciplinary team.

Oxytocine use low dose (10 units IV inf) slowly over 4-8 hr.

Methergine absolute CI

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SUMMARY

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SUMMARY

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