Reverse Vaccinology
Wage Indrya Nugraha
Edward Jenner 1796 h=p://www.wired.com/science/discoveries/news/2008/05/dayintech_0514#
Louis Pasteur 1886
h"p://www.icollector.com/Louis-‐Pasteur_i9688850
Reverse Vaccinology 1. Analisis komputer (In Silico) 2.IdenRfikasi anRgen 3. Animal test 4. Molecular epidemology 5. Uji klinis 6. Ijin dari regulator 7. Rekomendasi 8. Implementasi
Rappuoli R. (2010). Reverse vaccinology. Immunity Review 33 : 530-‐541.
Vaccinomic
Rappuoli, R (2000). Reverse Vaccinology. Genomics. 445-‐450.
Reverse Vaccinology
Biology Molekuler, Immunology, Genomic (-‐Omic), Komputasi & BioinformaRc.
Reverse Vaccinology
Epitope ; an=genic determinant Bagian/sisi anRgen Yang dikenali oleh reseptor AnRgen/AnRbodi. AnRgen : Molekul yang dikenali oleh sistem kekebalan tubuh
Reverse Vaccinology
Reverse Vaccinology
Epitope Linier & Epitope Non Linier
Reverse Vaccinology
Reverse Vaccinology
Reverse Vaccinology
BioinformaRc Public Domain, Desktop Applica=on (Free access-‐proprietary) : IEDB, ELLIPRO, GENEIOUS, CLC-‐BIO, EPIVAX, VAXIGN
Vaccinomic
Reverse Vaccinology
Grup B Meningococcus, Malaria, Tuberculosis, Syphilis, HepaRRs-‐B, HepaRRs-‐C
Daiar Pustaka H=p://www.epivax.com . h=p://www.immuneepitope.org/ . De Groot, Anne S., Cohen, Tobias., Ardito, Ma=hew.,(2010) Use of BioinformaRka to Predict MHC Ligands and T-‐Cell Epitopes: ApplicaRon to Epitope-‐Driven Vaccine Design. Methods in Microbiology.37:35-‐66. Rappuoli, R., Se=e, Alessandro., (2010). Reverse Vaccinology:Developing Vaccines in The Era of Genomics. Immunity. 33, 530-‐541. Vivona, Sandro., Gardy, J.L., (2008). Computer-‐aided biotechnology: from immun-‐informaRcs to reverse vaccinology.Trends in Biotechnology. 26, 190-‐200. Von Reyn, Fordham., Vuola, Jenni., (2002) New Vaccine for the PrevenRon of Tuberculosis. Vaccine 35:465-‐474. WHO, (2011) WHO Report ; Global Tuberculosis Control 2011. France. Xiong, Jin., (2006) Essen=al Bioinforma=cs. Cambridge University Press. New York.
TERIMAKASIH
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