The editor of The Journal of Pharmacology and Experimental Therapeutics wishes to express appreciation to the following
colleagues who acted as Guest Editors for Specific Fields in 1980:
Additionally, sincere thanks are due to 497 of our colleagues not on the Editorial Advisory Board who reviewed articles for the
Journal in 1980.
872
Edmund G. Anderson
Lewis Aronow
Uoyd Beck
John A. Bevan
David A. Blake
Theodore M. Brody
Edward J. Cafruny
Leonard Cook
William C. de Groat
Bahjat A. Faraj
Lawrence J. Fischer
Shri N. Gin
Leon GoJdberg
Dora B. Goldstein
Garrett J. Gross
John Harvey
Donald J. Jenden
Louis Lemberger
Roberto Levi
Louis Levy
Kafait U. Malik
Perry Molinoff
John C. McGiff
D. E. McMillan
David E. Potter
Arthur Raines
Lewis Seiden
Parkhurst Shore
Roger Smith
Solomon Snyder
Ewart Swinyard
David J. Tniggle
Norman Weiner
Theodore C. West
David P. Westfall
Thomas Westfall
Dixon M. Woodbury
Richard J. Wurtman
Ben Zimmerman
874 INDEX
and withdrawal (rats), 666effects of mazindol and homo-
logs (rats), 745effects of naltrexone dose and
history of naltrexone expo-
sure on food- and codeine-maintained responding(monkeys), 105
effects of naltrexone on narcoticdiscrimination (pigeons,
monkeys), 652
effects of thiamine deficiency(rats), 537
intravenous self-administration
of drugs during food depni-vation and satiation (rats),241
pentobarbital-reinforced, roleof pentobarbital drinking(monkeys), 114
three-choice drug discrimina-tion (rats), 254
Belinsky, S. A., see Reinke, L. A.,863
Benzolamide, effect on sodium en-try to cerebrospinal fluid
(rats),51[3H]Benzoyl-phenylalanyl-alanyl-
proline, metabolism by pul-monary angiotensin convert-ing enzyme in vivo, effects of
bradykinin, SQ 14225 oracute hypoxia (rabbits, dogs),263
Berkowitz, A. L., see Patrick, R.L., 686
Biotransformation, of methylmer-
curic chloride, influence ofchelating agents (rats), 500
Bircher, J., see Zysset, T., 198Bittar, E. E., see Helmer, P., 248Blake, D. A., see Spielberg, S. P.,
386
Blass, J. P., see Barclay, L. L., 537Bleomycin, effect on pulmonary
amine uptake (rabbits), 524Blood flow
coronary, in myocardial isch-emia, comparison of calciumantagonists (dogs), 20
renal, effects of lergotrile(dogs), 660
Blood pressureeffects of lergotrile (dogs), 660effects of prazosin (rats), 397increase, effects of interaction
between angiotensin andopioid peptides (rats), 619
Bohr, D. F., see Webb, R. C., 26Bone, resorption, parathyroid
hormone-stimulated, inhibi-
tion by ouabain (mice), 586
Borow, K. M., Spann, J. F. andCoulson, R. L.: The directmyocardial energetic re-
sponse to nitroglycerine in
the rabbit heart, 566
Bradykinin, effects on metabo-lism of [3H}benzoyl-phenyla-lanyl-alanyl-proline by pul-
monary angiotensin convert-
ing enzyme in vivo (rabbits,dogs), 263
Braincatecholamine content and up-
take, action of xylamine
(rats), 834
cerebral cortex, enhancementof y-aminobutynic acid inhi-bition by sodium valproate in
(rats),445cholinergic nerves in arteries of
(cats, rabbits), 544depletion and restoration of
synaptic plasticity by exoge-
nous catecholamines (kit-
tens, cats), 841
differences between mazindol
and homologs on biochemicaland behavioral responses(rats), 745
disposition of morphine in
(rats), 181
effects ofp-chloroamphetamineon locomotor activity andserotonin leveLs (rats), 738
effects of phencyclidine onturnover rate of acetylcholinein (rats), 733
measurement of imipramineand desmethylimipramine in
(rats), 461
potassium-induced release of
dopamine and norepineph-rine from, effects of catechol-amine uptake inhibitors(rats), 727
striatum, effects of amphet-amine on dopamine synthesisin (rats), 686
whole1 monoamines, effects ofreserpine (rats), 357
Branch, R. A., see James, R., 127Breese, G. R., see Lundberg, D.
B., 215
Brink, C., Duncan, P. G. andDouglas, J. S.: The responseand sensitivity to histamineof respiratory tissues from
normal and ovalbumin-sensi-tized guinea pigs: Effects of
cyclooxygenase and lipoxy-genase inhibition, 592
Brody, T. M., see Kim, D.-H., 559Brody, T. M., see Temma, K., 708
Brody, T. M., see Yamamoto, S.,
701
Bromobenzene, effect on drugmetabolism within liver lob-ule (rats), 127
2-Bromo-D-lysergic acid, diethyl-
amide bitartrate (BOL) dualactions on dorsal root poten-tials evoked by stimulation ofraphe nuclei (cats), 99
Bross, D. S., see Spielberg, S. P.,386
$-Bungarotoxin, cholinergic
blocking actions of (guineapigs, rabbits, rats, mice), 505
Bupropion, radioimmunoassayand pharmacokinetic profileof (dogs, rabbits, man, rats,mice), 602
Butcher, L. L., see Dudley, M. W.,834
Butz, R. F., Schroeder, D. H.,Welch, R M., Mehta, N. B.,Phillips, A. P. and Findlay, J.W. A.: Radioimmunoassayand pharmacokinetic proffleof bupropion in the dog, 602
Bylund, D. B.: Interactions ofneuroleptic metabolites withdopaminergic, alpha adre-nergic and muscarinic cholin-ergic receptors, 81
Ca�, inhibition of isoproterenolresponses in skeletal muscle(mice), 271
Cabbat, F. S., see Heikkila, R. E.,
745
Caffeine, effect on cardiac san-colemmal 5’-nucleotidase(rats), 489
Calcium-induced contraction of aortic
strips, effects of calmodulin
antagonists on (rabbits), 494
influx in aorta and mesentericarteries, inhibition by flunar-izine of (rats), 510
Calcium antagonists, comparisonon coronary blood flow inmyocardial ischemia (dogs),
20Calmodulin, antagonists, effects
on calcium-induced contrac-tion of aortic strips (rabbits),494
Canrenone, effect on Na�-K�-
adenosine triphosphatase, in-teraction with ouabain(guinea pigs), 784
Captopril, effect on nonenzymaticmethionine enkephalin mac-
tivation in ileum (guineapigs), 750
Caputy, A. J., Kim, Y. I. andSanders, D. B.: The neuro-muscular blocking effects of
therapeutic concentrations ofvarious antibiotics on normalrat skeletal muscle: A quan-titative comparison, 369
Carbamazepine to carbamaze-pine-10,11-epoxide pathway,
induction effect of phenobar-bital on (monkeys), 555
Carbendilhin, inactivation of to-bramycin, gentamicin, netil-micin and amikacin (man),345
Carbocromene, effects on myocar-dial oxygen consumption inisolated hearts (dogs), 306
Carbon tetrachloride, effect ondrug metabolism within liverlobule (rats), 127
Carbonic anhydrase inhibitors, ef-fect on sodium entry to cere-brospinal fluid (rats), 51
Carroll, M. E., France, C. P. andMeisch, R. A.: Intravenousself-administration of etoni-
tazene, cocaine and phency-clidine in rats during fooddeprivation and satiation, 241
Casu, M. and Gale, K.: Differen-tial effects of y-aminobutyricacid (GABA)-elevatingagents on the neuroleptic-in-duced activation of stniatal
tyrosine-hydroxylase: Evi-
dence that di-n-propylace-tate augments GABAergicneurotransmission, 177
Catecholamines (see also specificname)
content in brain, actions of xy-lamine on (rats), 834
effects on spinal sympathetic
reflexes (frogs), 170exogenous, intracortical spread
(kittens, cats), 841
hyperpolarization in superiorcervical ganglia, comparison
of receptors mediating (rab-bits),440
Catravas, J. D. and Gills, C. N.:Metabolism of [3H]ben.zoyl-phenylalanyl-alanyl-prolineby pulmonary angiotensinconverting enzyme in vivo:
Effects of bradykinin SQ14225 or acute hypoxia, 263
Catravas, J. D., Lazo, J. S. andGillis, C. N.: Biochemicalmarkers of bleomycin toxic-ity: Clearance of [‘4C]-5-hy-droxytryptamine and [3H}-norepinephnine by rabbitlung in vivo, 524
Catravas, J. D. and Waters, I. W.:Acute cocaine intoxication inthe conscious dog: Studies on
the mechanism of lethality,350
Ceftizoxime, renal excretion and
distribution (rats), 209
Cells, fat, perfused, growth hor-
mone stimulation of lipolysisand cyclic AMP in (rats), 15
Cerebrospinal fluid, sodium entryto, effect of carbonic anhy-
chase inhibitors and otherdrugs (rats), 51
Chelating agents, influence on dis-tribution and biotransforma-
tion of methylmercuric chlo-ride (rats), 500
Cheney, D. L., see Murray, T. F.,
733
Cheng, H. C., Gleason, E. M., Na-than, B. A., Lachmann, P. J.and Woodward, J. K.: Effectsof clonidine on gastric acidsecretion in the rat, 121
Cheng, K.-C., Lambert, J. J., Hen-derson, E. G., Smiowitz, H.and Epstein, P. M.: Postsyn-aptic inhibition of neuromus-cular transmission by trifluo-perazine, 44
Chikharev, V. N., see Gilmour, R.G., Jr., 390
Chinn, C., see Larson, A. A., 99Chiriquitoxin, new tool for
mapping ionic channels(frogs), 416
p-Chloroamphetamine, effects on
locomotor activity and sero-tonin levels (rats), 738
p-Chloromercuribenzyoate, iso-
lated inotropic action in iso-lated heart, influence ofmembrane stabilizing agents(guinea pigs), 768
p-Chloro-N-methylanilane de-
methylase, activity in liverand fetal tissues (man,chicks), 572
Chlorpromazine
INDEX 875
comparison of in vitro potency
at dopaminergic, alpha ad-renergic and muscarinic cho-
linergic receptor binding sites(sheep, rats), 81
pretreatment, effects on co-caine lethality (dogs), 350
Cho, A. K., see Dudley, M. W.,
834
Choline, high affinity uptake, incerebral arteries (cats, nab-bits), 544
Chromatography
gas-liquid, to measure levels of
morphine in plasma andbrain (rats), 181
high-performance liquid, andradioimmunoassay, determi-nation of fluphenazine, re-lated phenothiazine drugsand metabolites (rabbits,man), 36
Churchill, P., see Hatfield, M., 406
Ciguatoxin, actions in vas defer-ens (guinea pigs), 475
Clearancedrug, effect of obesity (man),
681
of [‘4C]-5-hydroxytryptamine
and [‘H]norepinephrine by
lung after bleomycin (rab-bits), 524
renal, of ceftizoxime (rats), 209Clomethiazole, effect of ethanol
on first-pass elimination of(rabbits), 198
Clonidineeffects on gastric acid secretion
(rats), 121effect on growth hormone se-
cretion (rats), 152Cocaine
effect on potassium-inducedrelease of dopamine and nor-epinephrine from brain
(rats), 727
intravenous self-administrationduring food deprivation and
satiation (rats), 241
poisoning (dogs), 350
Codeine
responding maintained by, ef-fects of naltrexone dose andhistory of naltrexone expo-
sure on (monkeys), 105transport mechanisms in ali-
mentary epithelia (rats), 285
Cohen, G., see Dembiec, D., 727Colburn, W. A., see Wurzburger,
R. J., 757Colchine, -induced supersensitiv-
ity in vas deferens, role of
changes in adrenergic nervesfor development of (rats), 516
Cole, A. E. and Shinnick-Gal-lagher, P.: Comparison of thereceptors mediating the cat-echolamine hyperpolaniza-
tion and slow inhibitory post-synaptic potential in sympa-thetic ganglia, 440
Colon, nicotine action on (rats),828
Cone, E. J., see Shannon, H. E.,379
Contractile force, in atria, effect
of aprindine on (frogs), 390Contraction, calcium-induced, of
aortic strips, effects of cal-modulin antagonists (nab-bits),494
Cooper, T. B., see Jason, K. M.,461
Copper, serum concentrationsand seizures, influence of D-
penicillamine (baboons), 138
Coulson, R. L., see Borow, K. M.,566
Cyclic AMP
in perifused fat cells, growthhormone stimulation of
(rats), 15levels, in isolated cardiac prep-
arations, effects of glucagon(rats, guinea pigs), 798
Cyclic AMP phosphodieterase,
inhibitors, effect on cardiacsarcolemmal 5’-nucleotidase(rats), 489
Cyclazocine, discrimination (rats),
254Cyclooxygenase, inhibition, ef-
fects on response and sensi-tivity to histamine of respi-
ratory tissues (guinea pigs),
592Cytotoxicity, of anticonvulsants,
role of arene oxides in (man,mice), 386
Dangman, K. H. and Hoffman, B.F.: In vivo and in vitro an-tiarrhythmic and arrhyth-mogenic effects of N-acetyl
procainamide, 851
Deamino-8 D-arglrnne vasopres-
sin, dose-dependent stimula-tion of renal prostaglandinsynthesis by (rats), 87
Deen, K., see Summy-Long, J. Y.,619, 630
Deficiency, thiamine, impairmentof behavior and acetylcholinemetabolism in (rats), 537
Delaage, M. A., see Puizillout, J.J., 791
Dembiec, D. and Cohen, G.:Potassium-induced release of
[3H]catecholamine frombrain: Effects of pre-exposureto catecholamine uptake in-hibitors, 727
Desmethylimipramine, effect onpotassium-induced release of
dopamine and norepineph-
rime from brain (rats), 727Desmond, P., see James, R., 127Dhalla, N. S., see Heyliger, C. E.,
489
Diabetes, hereditary, dose-depen-dent stimulation of renalprostaglandin synthesis bydeamino-8-D-arginine vase-
pressin (rats), 87
Diazepam
effect of obesity on distributionand clearance (man), 681
pretreatment, effects on co-caine lethality (dogs), 350
Dibutyryl-cyclic AMP, relaxation
of vascular smooth muscle by(rats, baboons, dogs, pigs,
cats), 26Dieu, D., see Godfraind, T., 510Digitalis, toxicity, effect of can-
renone (guinea pigs), 784
Digoxin, cardiac sensitivity, ef-fects of quinidine (guineapigs, rats), 559
Dihydromorphine, transportmechanisms in alimentary
epithelia (rats), 285Dilation, coronary, effects of tn-
mazosin (dogs), 3332,3-Dimercaptopropane- 1 -sulfo-
nate, influence on distribu-tion and biotransformation ofmethylmercuric chloride
(rats), 500Dimercaptosuccinic, influence on
distribution and biotransfor-mation of methylmercuric
chloride (rats), 500Diphenhydramine, effect on ino-
tropic action of p-chloromer-
cunibenzoate in isolated heart
(guinea pigs), 708
Dipyridamole, effect on cardiac
sarcolemmal 5’-nucleotidase(rats), 489
Disposition, of morphine in brain(rats), 181
Disobutamide, effects on electro-physiologic properties of car-
diac Purkinje fibers and pap-illary muscle (dogs), 549
Distributionand renal excretion of ceftizox-
ime (rats), 209
drug, effect of obesity (man),681
of methylmercuric chloride, in-fluence of chelating agents(rats), 500
Dita, effect on potassium-inducedrelease of dopamine and nor-epinephrine from brain
(rats), 727Divoll, M., see Abernethy, D. R.,
681
Dohrmann, M. L., Harrell, F. E.,
Jr. and Strauss, H. C.: Theeffects of disobutamide onelectrophysiologic properties
of canine cardiac Purkinje fi-bers and papillary muscle,549
L-Dopa, striatal dopamine forma-tion from (rats), 189
Dopamine
agonists and antagonists, influ-ence on locomotor activity
after opioid receptor agonists(rats), 451
brain, effects of mazindol andhomologs (rats), 745
formation in stniatum after L-
dopa (rats), 189in brain and small intestine, ef-
fects of reserpine (rats), 357receptor, presynaptic, stimula-
tion in cardiovascular actionsof lergotrile (dogs), 660
release from brain induced bypotassium, effects of cate-cholamine uptake inhibitors(rats), 727
synthesis in brain striatum, ef-
fects of amphetamine (rats),686
Douglas, J. S., see Brink, C., 592Doyle, A. S., see Vogh, B. P., 51Dubocovich, M. L., see Mas-
singham, R., 467Duckles, S. P.: Evidence for a
functional cholinergic inner-vation of cerebral arteries,544
Dudley, M. W., Butcher, L. L.,Kammerer, R. C. and Cho, A.K. The actions of xylamine
on central noradrenergic neu-rons, 834
Dun, N. J. and Karczmar, A. G.:Evidence for a presynapticinhibitory action of 5-hy-
droxytryptamine in a mam-
malian sympathetic ganglion,714
Duncan, P. G., see Brink, C., 592Dustman, R. E., see Snyder, E.
W.,299
Dyphylline, elimination in ure-mia, pharmacokinetics of(man), 340
Edema, paw, carrageenan-in-duced influence of dietaryprotein deficiency on sup-
pressant activity of anti-in-flammatory agents in (rats),
776
Eells, J. T., Makar, A. B., Noker,P. E. and Tephly, T. R.:Methanol poisoning and for-mate oxidation in nitrous ox-ide-treated rats, 57
Electrolytes, in urine, central ef-
fects of morphine, levor-phanol, methadone and en-dorphins (rats), 579
Electrophysiologic properties, of
cardiac Purkinje fibers andpapillary muscle, effects ofdisobutamide (dogs), 549
Electrophysiological effects, of N-
acetyl procainamide in car-diac tissues (dogs), 851
Elimination
of dyphylline in uremia, phar-macokinetics (man), 340
first-pass, of clomethiazole, ef-fect of ethanol (rabbits), 198
f3-Endorphin
central effects on urine volumeand electrolytes (rats), 579
inhibition of central actions ofangiotensin by (rats), 619
Enkephalin-analog, stimulation ofpulmonary J receptors by
(rats), 228Enkephalins
Leu5 and Met5, inhibition ofcentral actions of angiotensinby (rats), 619
met, nonenzymatic inactivationin ileum, effect of captopriland ascorbic acid on (guineapigs), 750
Enzymes, y-glutamyl cycle, in fe-tel liver (man), 697
Epilepsyinfluence of D-penicillamine on
seizure activity and trace
INDEX 877
turn after L-dopa administra-
tion, 189Heikkila, R. E., Cabbat, F. S.,
Manzino, L., Babington, R.G. and Houlihan, W. J.: Un-expected differences betweenmazindol and its homologs on
biochemical and behavioralresponses, 745
Helmer, P., Rusy, B. and Bittar,E. E.: Sensitivity to halo-thane of the sodium efflux insingle barnacle muscle fibers,
248
Henderson, E. G., see Cheng, K.-C., 44
Henningfield, J. E., see Meisch, R.A., 114
Herling, S.: Effects of naltrexone
dose and history of naltrex-one exposure on food- andcocaine-maintained respond-ing in rhesus monkeys, 105
Herling, S., see Valentino, R. J.,
652
Heyliger, C. E., Panagia, V. andDhalla, N. S.: Effect of cyclicAMP phosphodiesterase in-hibitors on cardiac sarcolem-
ma! 5’-nucleotidase, 489Hidaka, H., see Kanamori, M., 494
Hingston, S. J., see La Morte, W.
W., 638Histamine
H- and H2-receptors in gall-bladder, pH-dependent activ-ity (guinea pigs), 638
in vitro release from basophils,inhibition by zinc (man), 292
response and sensitivity of res-
piratory tissues to, effects of
cyclooxygenase and lipoxy-genase inhibition (guinea
pigs), 592Hoffman, B. F., see Dangman, K.
H., 851Holtzman, S. G., see White, J. M.,
254
Horwitz, J., see Lucot, J. B., 738Houlihan, W. J., see Heikkila, R.
E., 745
Huidobro, F., see Huidobro-Toro,J. P., 579
Huidobro-Toro, J. P. and Hui-dobro, F.: Central effects ofmorphine, levorphanol, (-)-
methadone and the opioid-like peptides /3-endorphinand D-alanine2-methiOflineenkephalinamide on urine
volume outflow and electro-lytes, 579
Hyaluronidase, effect on resist-
ance and transport after cor-onary flow reduction (dogs),62
Hydralozine, effect in arteries andveins (man), 204
6-Hydroxydopamine, effects on
disposition of norepinephrine
in aorta (rabbits), 162
5-Hydroxyindoleacetic acid, ra-
dioimmunoassay, use of iodi-
nated derivative (rabbits),791
5-Hydroxytryptamine (see also
Serotonin)inhibition of acetylcholine
release in sympathetic gan-
glion by (rabbits), 714[‘4C]-5-Hydroxytryptamine, clear-
ance by lung after bleomycin(rabbits), 524
6-Hydroxytryptamine, endoge-nous, intracortical spread(kittens, cats), 841
5-Hydroxytryptophan, effect on
growth hormone secretion
(rats), 152Hypertension, tolerance to pra-
zocin in, involvement ofrenin-angiotensin system
(rats), 397Hypersensitivity reactions, in vi-
tro, cardiac, thromboxaneand prostacyclin release dur-ing (guinea pigs), 157
Hypoxia, acute, effects on metab-
olism of [3H]benzoyl-pheny-
lalanyl-alanyl-proline by pul-monary angiotensin convert-ing enzyme in vivo (rabbits,dogs), 263
Ileum
effect of captopril and ascorbicacid on nonenzymatic methi-onine enkephalin inactiva-tion in (guinea pigs), 750
isolated, effect of antimorphineantibodies on antagonist-pre-
cipitated contracture in(guinea pigs), 820
Imipramine, prenatal exposure,effect on early behavioral de-velopment and beta adrener-
gic receptors (rats), 461
Inotropic actionof p-chloromercuribenzoate in
isolated heart, influence ofmembrane stabilizing agent(guinea pigs), 708
ofisoproterenol in heart (mice),314
of ouabain in heart (guineapigs), 701
Intestineformation of 1-thiocarbamoyl-
2-imidazolidinone from niri-
dazole in (mice), 363small, monoamines, effects of
reserpine (rats), 357small, transit, effects of reser-
pine on (rats), 357Inturnisi, C. E., see Ling, G. S. F.,
147
Ionic channels, mapping, by chi-niquitoxin (frogs), 416
Isoproterenolcomparison with glucagon on
cyclic AMP levels in isolatedcardiac preparations (rats,guinea pigs), 798
inotropic action in heart (mice),314
relaxation of vascular smooth
muscle by (rats, baboons,dogs, pigs, cats), 26
responses in skeletal muscle,
Ca� inhibition of (mice), 271-stimulated phosphorylase a
formation in heart (mice),
326
Itakura, T. see Kasamatsu, T., 841
Iwamoto, E. T.: Locomotor activ-
ity and antinociception after
putative mu, kappa andsigma opioid receptor ago-nists in the rat: Influence ofdopaminergic agonists andantagonists, 451
Iwasa, J., see Masutani, T., 812
Jackson, M. J.: Transport mech-
anisms for narcotics and nan-
cotic antagonists in alimen-
tary epithelia, 285
James, H., Desmond, P., K#{252}pfer,
A., Schenker, S. and Branch,H. A.: The differential locali-zation of various drug metab-
olizing systems within the rat
liver lobule as determined bythe hepatotoxins allyl alco-
hol, carbon tetrachloride andbromobenzene, 127
Jason, K. M., Cooper, T. B. andFriedman, E.: Prenatal expo-sure to imipramine alters
early behavioral develop-ment and beta adrenergic re-ceptors in rats, 461
Jobe, P. C., see Stewart, J. J., 357
Jolly, S. R., Hardman, H. F. and
Gross, G. J.: Comparison oftwo dihydropynidine calcium
antagonists on coronary col-
lateral blood flow in acutemyocardial ischemia, 20
Jonsson, G., see Kasamatsu, T.,841
Jurevichus, J. A., see Gilmour, R.G., Jr., 390
Kammerer, R. C., see Dudley, M.W., 834
Kanamori, M., Naka, M., Asano,M. and Hidaka, H.: Effects ofN (6-aminohexyl) - 5 - chloro-1 - aphthalenesulfonamideand other calmodulin antag-onists (calmodulin interact-
ing agents) on calcium-in-
duced contraction of rabbitaortic strips, 494
Kao, C. Y., Yeoh, P. N., Goldfin-ger, M. D., Fuhrman, F. A.
and Mosher, H. S.: Chiniqui-
toxin, a new tool for mappingionic channels, 416
Kaplan, H. R., see Smith, R. D.,
397
Karasawa, T., see Masuda, Y., 805
Karczmar, A. G., see Dun, N. J.,714
Karras, P. J. and North, R. A.:
Acute and chronic effects ofopiates on single neurons of
the myenteric plexis, 70
Kasamatsu, T., Itakura, T. andJonsson, G.: Intracorticalspread of exogenous cate-
cholamines: Effective con-centration for modifying con-tical plasticity, 841
Kasuya, Y., see Saito, A., 516Kauffman, F. C., see Reinke, L.
A., 863
Keil, L. C., see Summy-Long, J.
619, 630
Kelly, M., see Gross, S. H., 271
Kidney
clearance of ceftizoxime (rats),
209
function, effects of prostaglan-
din F�k (dogs), 674
prostaglandin synthesis, dose-dependent stimulation by
deamino-8-D-arginine vase-
pressin (rat.s), 87
vascular and tubular, effects ofvanadate (rats), 406
Killam, E. K., see Alley, M. C.,138
Killian, A. K., Schuster, C. R. andWainer, B. H.: Effect of anti-morphine antibodies on an invitro correlate of antagonist-precipitated opiate absti-
nence, 820Kim, D.-H., Akera, T. and Brody,
T. M.: Effects of quinidine onthe cardiac-glycoside sensi-tivity of guinea-pig and rat
heart, 559Kim, D.-H., see Yamamoto, S.,
701
Kim, Y. I., see Caputy, A. J., 369Kinetics
of reaction top-chloro-N-meth-ylaniine demethylase in liverand fetal tissues (man,chicks), 572
plasma, of phenylethanolamineand N-methyl phenyletha-nolamine (dogs), 379
Kliner, D. J., see Meisch, R. A.,114
Kondo, H., see Temma, K., 708
Krieger, A. J., see Sapru, H. N.,228
Krieger, N. S. and Tashjian, A.H., Jr.: Inhibition by ouabainof parathyroid hormone-stimulated bone resorption,586
Krishnaswamy, K., see Rollins,
D., 697
Kuhn, C. M. and Schanberg, S.M.: Maturation of centralnervous system control ofgrowth hormone secretion inrats, 152
K#{252}pfer,A., see James, R., 127Kuramatsu, I., see Miura, A., 505
Lachmann, P. J., see Cheng, H.C., 121
Lambert, J. J., see Cheng, K.-C.,44
La Monte, W. W., Hingston, S. J.
and Wise, W. E.: pH-depen-dent activity of H1- and H�-histamine receptors inguinea-pig gallbladder, 638
Langer, S. Z., see Massingham, R.,
467
Larson, A. A., Chinn, C., Proudflt,H. K. and Anderson, E. G.:Dual actions of lysergic aciddiethylamide tartrate (LSD),
2-bromo-D-lysergic acid di-
ethylamide bitartrate (BOL)and methysergide on dorsal
878 INDEX
root potentials evoked bystimulation of raphe nuclei,99
Larsson, A., see Rollins, D., 697Lazo, J. S., see Catravas, C. D.,
524Lee, C-S. C., Wang, L H., Ma-
jeske, B. L. and Marbury, T.C.: Pharmacokinetics of dy-phylline elimination byuremic patients, 340
Lee, C.-Y., see Miura, A., 505Leff, A. R. and Munoz, N. M.:
Evidence for two subtypes ofalpha adrenergic receptors incanine airway smooth mus-cle, 530
Lergotrile, cardiovascular actions,stimulation of presynaptic
dopamine receptors in (dogs),660
Levi, R., see Allan, G., 157
Levin, J. A. and Wilson, S. E.: Theeffects of 6-hydroxydopa-mine on the disposition ofnorepinephrine in the rabbit
aorta, 162Levorphanol, central effects on
urine volume and electrolytes(rats), 579
Levy, R. H., see Patel, I. H., 555Lichtenstein, L. M., see Marone,
G., 292Lieber, C. S., see Matsuzaki, S.,
133Lieber, C. S., see Vittek, J., 411
Ling, G., see Nozaki, M., 666TAng, G. S. F., Umans, J. G. and
Inturrisi, C. E.: Methadone:Radioimmunoassay andpharmacokinetics in the rat,147
IApe, S. and Moulds, R. F. W.: Invitro differences between hu-man arteries and veins intheir responses to hydrala-zine, 204
Lipolysis, in perfused fat cells,growth hormone stimulationof (rats), 15
Lipoxygenase, inhibition, effectson response and sensitivity tohistamine of respiratory tin-sues (guinea pigs), 592
Liverp-chloro-N-methylanilane de-
methylase activity in (man,chicks), 572
effect of ethanol on testoster-one-5a-reductase in (rats),411
ethanol oxidation at highethanol concentrations, roleof alcohol dehydrogenase(rats), 133
fetal, glutathione and y-gluta-myl cycle enzymes in (man),697
influence of dietary protein de-ficiency on lysosome stabiliz-ing activity of anti-inflam-matory agents in (rats), 776
lobule, drug metabolism, effects
of hepatoxins (rats), 127perfused, conjugation of p-ni-
trophenol in (rats), 863Locomotor activity
after opioid receptor agonists,influence of dopaminergic ag-
onists and antagonists (rats),451
effects ofp-chloroamphetamine(rats), 738
Lokhandwala, M. F., see Barrett,RJ.,660
Long, K. J., see Sengupta, K., 15Lucot, J. B., Horwitz, J. and Sei-
dent, L. S.: The effects of p-chloroamphetamine admin-istration on locomotor activ-ity and serotonin in neonatal
and adult rats, 738
Lundberg, D. B., Breese, G. R.and Mueller, R. A.: Amino-phylline may stimulate res-piration in rats by activationof dopaminergic receptors,215
Lungangiotensin-converting enzyme,,
effects of bradykinin, SQ14225 or acute hypoxia onmetabolism of [3H]benzoyl-phenylalanyl-alanyl-proline
in vivo by (rabbits, dogs), 263effect of bleomycin on amine
uptake by (rabbits), 524sensory receptors, stimulation
by enkephalin-analog (rats),228
Luttinger, D., see Osbahar, A. J.
III, 645Lymphocytes, cytotoxicity in, an-
ticonvulsant role of arene ox-ides (man, mice), 386
Lysergic acid diethylamide tar-trate (LSD), dual actions,on dorsal root potentialsevoked by stimulation ofraphe nuclei (cats), 99
Macho, P. and Vatner, S. F.: Ef-fects and mechanism of ac-tion of tnimazosin on coro-nary and left ventricular dy-namics in conscious dogs, 333
MacLeod, K. M., Rodgers, R Land McNeil!, J. H.: Charac-terization of glucagon-in-duced changes in rate, con-tractiity and cyclic AMPlevels in isolated cardiac
preparations of the rat and
guinea pig, 798
Maes, R. A. A., see Plomp, G. J.J., 181
Majeske, B. L, see Lee, C.-S. C.,340
Makar, A. B., see Bells, J. T., 57
Malcolm, R. D. and Alkana, R L:
Temperature dependence ofethanol depression in mice,770
Manzino, L, see Heikkila, R E.,745
Marbury, T. C., see Lee, C.-S. C.,340
Marcum, E. A., see Wurzburger,
R. J., 757Marone, G., Findlay, S. R and
Lichtenstein, L. M.: Modula-tion of histamine release fromhuman basophils in vitro byphysiological concentrations
of zinc, 292Mason, G. A., see Osbahr, A. J.
III, 645
Massingham, R., Dubocovich, M.L, Shepperson N. B. andLanger, S. Z.: In vivo selectiv-
ity of prazosin but not of
WB41O1 for postsynaptic al-p/ia-i adrenoceptors, 467
Masuda, Y., Utsui, Y., Shiraishi,Y., Karasawa, T., Yoshida, K.and Shimizu, M.: Evidencefor a synergistic interactionbetween phenytoin and phe-nobarbital in experimentalanimals, 805
Masutani, T., Seyama, I., Nara-hashi, T. and Iwasa, J.: Struc-ture-activity relationship forgrayanotoxin derivatives infrog skeletal muscle, 812
Mather, L. E., Gourlay, G. K.,Parkin, K. S. and Roberts, J.
..‘ G.: Pharmacodynamics ofminaxolone, a new steroidalanesthetic, 481
Matsuzaki, S., Gordon, E. and Lie-
ber, C. S.: Increased alcoholdehydrogenase independentethanol oxidation at high
ethanol concentrations in iso-lated rat hepatocytes: The ef-fect of chronic ethanol feed-ing, 133
Mazindol
and homologs, different effectson biochemical and behav-
ioral responses (rats), 745effect on potassium-induced
release of dopamine and nor-epinephnine from brain(rats), 727
McEnlane, B., see Tam, Y. K., 764
McNeill, J. H., see MacLeod, K.
M., 798
Mecillinam, inactivation of tobra-mycin, gentamicin, netilmicinand amikacin (man), 345
Medzihradsky, F., see Valentino,
H. J., 652Meht.a, N. B., see Butz, R. F., 602Meiach, R. A., see Carroll, M. E.,
241Meisch, H. A., Kliner, D. J. and
Henningfield, J. E.: Pento-barbital drinking by rhesusmonkeys: Establishment andmaintenance of pentobarbi-
tel-reinforced behavior, 114Melamed, E., see Hefti, F., 189Mellits, E. D., see Spielberg, S. P.,
386
Membrane currents, in peripheral
nerve, effects ofgallamine tri-ethiodide (rats, frogs), 719
Mephenytoin, cytotoxicity, role ofarene oxides (man, mice), 386
Merz, H., see Valentino, R. J., 652Metabolism
acetylcholine, in thiamine defi-ciency, impairment (rats),
537
arachidonic acid, relation tohistamine-induced contrac-
tion in airway muscle (guineapigs), 592
drug, in obesity (man), 681drug, within liver lobule, effects
of hepatoxins (rats), 127ethanol, after chronic ethanol
consumption, role of alcoholdehydrogenase (rats), 133
of [3H]benzoyl-phenylalanyl-alanyl-proline by pulmonaryangiotensin converting en-zyme in vivo, effects of brady-kinin, SQ 14225 or acute hy-poxia (rabbits, dogs), 263
of niridazole in intestine (mice),363
Metabolites
neuroleptic, interactions withdopaminergic, alpha adre-
nergic and muscaninic cholin-ergic receptors (sheep, rats),81
phenothiazine, determination
by combined high-perform-ance liquid chromatographyand radioimmunoassay (rab-bits, man), 36
Methadoneinteraction with theophylline,
effect upon respiration and
ventilation (dogs), 278radioimmunoassay and phar-
macokinetics (rats), 147
transport mechanisms in ali-mentary epithelia (rats), 285
(-)-Methadone, central effects onurine volume and electrolytes(rats), 579
Methanol, poisoning in nitrousoxide treatment (rats), 57
Methazolamide, effect on sodium
entry to cerebrospinal fluid(rats), 51
Methylmercunic chloride, distri-bution and biotransforma-tion, influence of chelatingagents on (rats), 500
N-Methyl phenylethanolamine,physiologic effects andplasma kinetics of (dogs), 379
Methylxanthines (see specific
drug)Methysergide, dual actions on
dorsal root potentials evokedby stimulation of raphe nu-clei (cats), 99
Metoclopramide, dose-dependentpharmacokinetics of (rats),764
Mezlocillin, inactivation of tobra-mycin, gentamicin, retilmicinand amikacin (man), 345
Miller, D. D., see Fuder, H, 1Miller, R. L, see Wurzburger, R.
J., 757Minaxolone, new steroidal anes-
thetic, pharmacodynamics of(sheep), 481
Miura, A., Muramatsu, I., Fuji-wara, M., Hayashi, K. andLee, C.-Y., Species and re-gional differences in cholin-
880 INDEX
Oxidationformate, in nitrous oxide treat-
ment (rats), 57ethanol, at high ethanol con-
centrations in liver, role of
alcohol dehydrogenase (rats),133
Oxygen, myocardial consumption,effects of carbocromene(dog), 306
Palatini, P., see Finotti, P., 784
Panagia, V., see Heyliger, C. E.,489
Pancuronium, pretreatment, ef-fects on cocaine lethality(dogs), 350
Papaverine, effect on cardiacsarcolemmal 5’-nucleotidase(rats), 489
Parathyroid-hormone, -stimu-lated bone resorption, inhi-bition by ouabain (mice), 586
Parkin, K. S., see Mather, L. E.,481
Patel, I. H., Wedlund, P. andLevy, R. H.: Induction effectof phenobarbital on the car-bamazepine to carbamaze-pine-10,11-epoxide pathwayin rhesus monkeys, 555
Patil, P. N., see Fuder, H., 1
Patrick, R. L., Berkowitz, A. L.and Regenstein, A. C.: Effectsof in vivo amphetamine ad-
ministration on dopamine
synthesis regulation in rat
brain striatal synaptosomes,686
D-Peniclllamine, influence upon
seizure activity and tracemetal status (baboons), 138
Penicillins, semisynthetic (see
specific drug)Pentobarbita!
and phencyclidine, on fixed-in-terval performance (mon-keys), 61
drinking, role in pentobarbital-reinforced behavior (mon-keys), 114
effect on growth hormone so-cretion (rats), 152
enhancement of spike fre-quency adaption in neuronsby (sea hares), 222
Petschke, T., see Rilkind A. B.,
572
pH, dependent activity of H1- andH2-histamine receptors ingallbladder (guinea pigs), 638
Pharmacodynamics, of minaxo-lone (sheep), 481
Pharmacokinetics (see also kinet-ics)
dose-dependent, of metoclo-pramide (rats), 764
of bupropion (dogs, rabbits,man, rats, mice), 602
of carbamazepine, effects ofphenobarbita! (monkeys),
555of dyphylline elimination in
uremia (man), 340of methadone (rats), 147
Phenacemide, cytotoxicity, role of
arene oxides (man, mice), 386Phencyclidine
and pentobarbital, effects onfixed-interval performance
(monkeys), 611effect on turnover rate of ace-
tylcholine in brain (rats), 733intravenous self-administration
during flood deprivation and
satiation (rats), 241Phenobarbital
cytotoxicity, role of arene ox-ides (man, mice), 386
effect on inotropic action of p-chloromercuribenzoate inisolated heart (guinea pigs),708
enhancement of spike fre-quency adaption in neuronsby (sea hares), 222
induction effect on carbamaze-pine to carbamazepine-10,ii-epoxide pathway (monkeys),555
synergistic interaction with
phenytoin (mice, rabbits),805
Phenothiazines, determination by
combined high-performanceliquid chromatography andradioimmunoassay (rabbits,man), 36
Phenylethanolamine, physiologic
effects and plasma kinetics of
(dogs), 379Phenytoin
cytotoxicity, role of arene ox-ides (man, mice), 386
synergistic interaction withphenobarbital (mice, rab-bits), 805
Phillips, A. P., see Butz, R. F., 602Phosphorylase a, isoproterenol-
stimulated formation in heart(mice), 326
Pickering, L. K. and Rutherford,I.: Effect of concentrationand time upon inactivation oftobramycin, gentamycin, ne-tilmicin and amikacin byazlocilhin, carbenicillin, mecil-
linam, mezlocillin and piper-acillin, 345
Pimozide, pretreatment, effectson cocaine lethality (dogs),350
Piperacillin, inactivation of tobra-
mycin, gentamicin, netilmicin
and amikacin (man), 345
Plans-Bohne, F.: The influence ofchelating agents on the dis-tnibution and biotransforma-tion of methylmercuric chlo-ride in rats, 500
Plasma
concentrations of anti-inflam-matory agents, influence ofdietary protein deficiency(rats), 776
kinetics, of phenylethanola-mine and N-methyl phenyl-ethanolamine (dog), 379
Plomp, G. J. J., Maes, R. A. A.and van Rhee, J. M.: Dispo-sition of morphine in ratbrain: Relationship to biolog-
ical activity, 181
Poisoning
cocaine (dogs), 350methanol, in nitrous oxide
treatment (rats), 57
Potassium -induced release of do-pamine and norepinephrinefrom brain, effects of cate-cholamine uptake inhibitors(rats), 727
Potassium channel, blockage bychiniquitoxin (frogs), 416
Potentialaction, in skeletal muscle, effect
of grayanotoxin (frogs), 8i2dorsal root, evoked by stimula-
tion of raphe nuclei, dual ac-tions ofserotonin antagonists(cats), 99
membrane, of saphenous an-tery, effect of reserpine (rab-bits), 430
slow inhibitory postsynaptic, insuperior cervical ganglia, me-diation by catecholamine re-ceptors (rabbits), 440
transmembrane, effects of N-
acetyl procainamide (dogs),851
Prange, A. J., Jr., see Osbahr, A.J. III, 645
Prazosinalpha-i adrenoceptor selectiv-
ity of (cats, dogs), 467tolerance to, involvement of
renin-angiotensin system
(rats), 397Price, J. D. E., see Tam, Y. K.,
764
Procainamide, effect on inotropicaction of p-ch!oromercuri-benzoate in isolated heart
(guinea pigs), 708Propranolol
effect on inotropic action of p-
chloromercunibenzoate inisolated heart (guinea pigs),708
pretreatment, effects on co-caine lethality (dogs), 350
Prostacyclin, release from heartduring hypersensitivity reac-tions in vitro (guinea pigs),157
Prostaglandin, renal synthesis,dose-dependent stimulation
by deamino-8-o-arginine va-sopressin (rats), 87
Prostaglandin F�,,, effects on renalfunction (dogs), 674
Prostate, effect of ethanol on tes-tosterone-5a-reductase in(rats), 411
Protamine, effect on resistanceand transport after coronaryflow reduction (dogs), 62
Protein, deficiency, dietary, influ-ence on lysosome stabilizingand paw edema suppressantactivity of anti-inflammatoryagents (rats), 776
Proudfit, H. K., see Larson, A. A.,
99
Puizillout, J. J. and Delaage, M.A.: Radioimmunoassay of 5-hydroxyindole acetic acid us-
ing an iodinated derivative,
791
Purkinje fiberscardiac, effects of disobutamide
on electrophysiologic prop-erties of (dogs), 549
isolated, effects ofN-acetyl pro-
cainamide (dogs), 851
Quinidine, effects on cardiac gly-coside sensitivity (guineapigs, rats), 559
Radioimmunoassayand high-performance liquid
chromatography, determina-
tion of fluphenazine, relatedphenothiazine drugs and me-
tabolites (rabbits, man), 36
for tetracycline (rabbits, dogs),
10
of bupropion (dogs, rabbits,man, rats, mice), 602
of halopenidol (rabbits, rats),
757of 5-hydroxyindoleacetic acid,
use of iodinated derivative
(rabbits), 791
of methadone (rats), 147
to measure levels of morphine
in plasma and brain (rats),181
Rane, A., see Rollins, D., 697Rappaport, S. C., see Vittek, J.,
411
Receptors
alpha adrenergic, blockade by
tnimazosin (dogs), 333alpha adrenergic, interactions
with neuroleptic metabolites(sheep, rats), 81
alpha adrenergic, postsynaptic,
differentiation by yohimbine
(rats), 235
beta adrenergic, early develop-
ment, effect of prenatal ex-posure to imipramine (rats),461
catecholamine, mediating cate-
cholamine hyperpolarizationand slow inhibitory postsyn-aptic potential in superior
cervical ganglia (rabbits), 440dopamine, presynaptic, stimu-
lation in cardiovascular ac-tions of lergotrile (dogs), 660
dopaminergic, aminophylline-
induced stimulation of respi-ration by activation of (rats),215
dopaminergic, interactions withneuroleptic metabolites(sheep, rats), 81
Hr and H2-histamine, pH-de-pendent activity in gallblad-der (guinea pigs), 638
muscaninic cholinergic, interac-tions with neuroleptic me-
tabolites (sheep, rats), 81nicotinic, in colon (rat), 828opiate, blockade, effect on an-
giotensin-induced drinkingand vasopressin release(rats), 630
opioid, agonists, locomotor ac-tivity and antinociception
after (rats), 451
pulmonary J, stimulation byenkephalin-analog (rats), 228
Regenstein, A. C., see Patrick, R.L., 686
Reinke, L. A., Belinsky, S. A., Ev-ans, H. K., Kauffman, F. C.
enkephalin-analog, 228
Sanders, D. B., see Caputy, A. J.,369
Schanberg, S. M., see Kuhn, C.M., 152
Schauf, C. L., see Smith, K. J., 719
Schenker, S., see James, R., 127
in amphibian and mamma-
han peripheral nerve, 719Smith, R. D., Tessman, D. K. and
Kaplan, H. R.: Acute toler-ance to prazosin in conscioushypertensive rats: Involve-
ment ofthe renin-angiotensm
nophylline-induced (rats),215
Stomachperfused, effects of clonidine on
gastric acid secretion in(rats), 121
steric aspects of alpha adreno-
and Thurman, R. G.: Conju-
gation ofp-nitrophenol in theperfused rat liver: The effectof substrate concentrationand carbohydrate reserves,
Schlehuber, C., see Snyder, E. W.,299
Schlitt, S. C., see Olsen, G. D., 278
Scholtholt, J., see Fiedler, V. B.,306
system, 397
Smooth muscle (see Muscle,smooth)
Snyder, E. W., Dustman, R. E.and Schlehuber, C.: Nalox-
receptors of (rabbit), 1Stone, H. L., see Gwirtz, P. A., 92Strandhoy, J. W., see Zook, T. E.,
674Strauss, H. C., see Dohrmann, M.
863
Renin-angiotensin system, in-volvement in tolerance to
Schroeder, D. H., see Butz, R. F.,602
Schuster, C. R., see Killian, A. K.,
one epileptogenesis in mon-keys, 299
Sodium
L., 549Stniatum
brain, effects of amphetamine
prazosin (rats), 397 820 efflux in muscle fibers, effect of on dopamine synthesis in
Reserpineeffects on monoamines and in-
testinal transit (rats), 357
Secretiongastric acid, effects of clonidine
(rats), 121
halothane (barnacle), 248
entry to cerebrospinal fluid, ef-fect ofcarbonic anhydrase in-
(rats), 686haloperidol levels, radioimmu-
noassay for (rabbits, rats),
effect on sensitivity and mem-brane potential of saphenousartery (rabbits), 430
Respiration
aminophylline-induced stimu-lation by activation of dopa-
minergic receptors (rats), 215effect of theophylline and
methadone interaction upon
of growth hormone, maturation
of central nervous systemcontrol of (rats), 152
Seident, L. S., see Lucot, J. B., 738
Seizuresand trace metal status, influ-
ence of D-penidillamine (ba-boons), 138
naloxone (monkeys), 299
hibitors and other drugs on
(rats), 51
Sodium channelsblockage by
(frogs), 416grayanotoxin
(frogs), 812Sodium-potassium pump, sites in
smooth muscle (guinea pigs),
757site of dopamine formation
after L-dopa (rats), 189tyrosine hydroxylase, effects of
y-aminobutyric acid-elevat-ing agents on neuroleptic-in-
duced activation of(rats), 177
Summy-Long, J. Y., Keil, L. C.,
Deen, K., Rosella, L. and(dogs), 278 Sengupta, K., Long, K. J. and Al- 692 Severs, W. B.: Endogenous
Rifkind, A. B. and Petschke, len, D. 0.: Growth hormone Sodium pump, electrogenic, ef- opioid peptide inhibition ofT.: p-Chloro-N-methylani- stimulation of lipolysis and fects of isoproterenol, dibu- the central actions of angio-line demethylase activity in cyclic AMP levels in perfused tyryl-cyclic AMP and theo- tensin, 619liver and extrahepatic tissues fat cells, 15 phylline (rats, baboons, dogs, Summy-Long, J. Y., Keil, L. C.,of the human fetus and in Sensitivity, of saphenous artery, pigs, cats), 26 Deen, K. and Severs, W. B.:chick embryo liver, 572 effect of reserpine (rabbits), Sodium valproate, enhancement Opiate regulation of angio-
Roberts, J. G., see Mather, L. E., 430 of y-aminobutynic acid inhi- tensin-induced drinking and481 Serotonin (see also 5-Hydroxy- bition (rats), 445 vasopressin release, 630
Robinson, R. L., see Abel, P. W., tryptamine) Southren, A. L., see Vittek, J., 411 Supersensitivity, colchicine-in-430 antagonists, dual actions on Spann, J. F., see Borow, K. M., duced, in vas deferens, role of
Rodgers, R. L., see MacLeod, K. dorsal root potentials evoked 566 changes in adrenergic nervesM., 798 by stimulation of raphe nu- Spector, S., see Wurzburger, R. J., for development of (rats), 516
Rollins, D., Larsson, A., Steen, B., clei (cats), 99 757Krishnaswamy, K., Hagen- brain, effects of mazindol and Spielberg, S. P., Gordon, G. B., Tachibana, K., see Ohizumi, Y.,
feldt, L., Mold#{233}us, P. and homologs (rats), 745 Blake, D. A., Mellits, E. D. 475
Rane, A.: Glutathione and y- in brain and small intestine, ef- and Bross, D. S.: Anticonvul- Tam, Y. K., Axelson, J. E., Mc-glutamyl cycle enzymes in fects of reserpine (rats), 357 sent toxicity in vitro: Possible Erlane, B., Ongley, R. and
human fetal liver, 697 levels, brain, effects of p-chlo- role of arene oxides, 386 Price, J. D. E.: Dose-depen-Romano, C.: Nicotine action on roamphetamine (rats), 738 Spike frequency adaption, in neu- dent pharmacokinetics of
rat colon, 828 Serum, haloperidol levels, ra- rons, barbiturate enhance- metoclopramide in rat: An ef-
Rosella, L., see Summy-Long, J. dioimmunoassay for (rabbits, ment of (sea hares), 222 fect of hemoperfusion?, 764
Y., 619 rats), 757 Spinal cord, sympathetic reflexes, Tashjian, A. H., Jr., see Knieger,
Rosenshtraukh, L. V., see Gil- Severs, W. B., see Summy-Long, catecholamine effects on N. S., 586
mour, R. G., Jr., 390 J. Y., 619, 630 (frogs), 170 Temma, K., Akera, T., Brody, T.Ruffolo, R. R., Jr., Waddell, J. E. Seyama, I., see Masutani, T., 812 Spleen, isolated perfused, selec- M. and Kondo, H.: Positive
and Yaden, E. L.: Postsyn- Shader, R. I., see Abernethy, D. tivities of prazocin and WB inotropic action of p-chlo-aptic alpha adrenergic recep- R., 681 4101 in (cats, dogs), 467 romercuribenzoate in iso-tor subtypes differentiated by Shannon, H. E., Cone, E. J. and SQ 14225, effects on metabolism lated guinea-pig heart: Influ-yohimbine in tissues from the Yousefnejad, D.: Physiologic of [3H]benzoyl-phenylalanyl- ence of membrane stabilizingrat. Existence of alpha-2 ad- effects and plasma kinetics of alanyl-proline by pulmonary agents, 708
renergic receptors in rat phenylethanolamine and its angiotensin converting en- Temperatureaorta, 235 N-methyl homolog in the zyme in vivo (rabbits, dogs), body, comparison of effects of
Rusy, B., see Helmer, P., 248 dog, 379 263 phenylethanolamine and N-Rutherford, I., see Pickering, L. Shepperson, N. B., see Mas- Steen, B., see Rollins, D., 697 methyl phenylethanolamine
K., 345 singham, R., 467Shibata, S., see Ohizumi, Y., 475
Stewart, J. J. and Jobe, P. C.:Effects of reserpine on mono-
on (dogs), 379dependence of ethanol depres-
Saito, A., Kasuya, Y. and Goto, Shimizu, M., see Masuda, Y., 805 amines and intestinal transit sion on (mice), 770K.: The role ofmorphological Shinnick-Gallagher, P., see Cole, in the rat, 357 Tephly, T. R., see Eells, J. T., 57and functional changes in ad- A. E., 440 Stimulation Terakawa, M., Tsuchiya, T., Wa-renergic nerves for the devel- Shinnick-Gallagher, P., see Un- electrical, of raphe nuclei, dual tanabe, Y. and Noguchi, H.:opment ofcolchicine-induced desser, E. K., 170 actions of serotonin antago- Renal excretion and distri-
supersensitivity in the rat vas Shiraishi, Y., see Masuda, Y., 805 mats on dorsal root potentials bution of ceftizoxime in rats,deferens, 516 Smiowitz, H., see Cheng, K.-C., evoked by (cats), 99 209
Saline, discrimination (rats), 254 44 of pulmonary J receptors by en- Tessman, D. K., see Smith, R. D.,Sapru, H. N., Willette, R. N. and Smith, K. J. and Schauf, C. L: kephalin-analog (rats), 228 397
Knieger, A. J.: Stimulation of Effects of gallamine triethio- of respiration by activation of Testosterone-5a-reductase, inpulmonary J receptors by an dide on membrane currents dopaminergic receptors, ami- oral tissues, effect of ethanol
INDEX 881
chiriquitoxin
binding site
882 INDEX
(rats), 411Tetracycline, radioimmunoassay
for (rabbits, dogs), 10Tetrodotoxin, comparison with
chinquitoxin (frogs), 416Theophylline
effect on cardiac sarcolemmal
5’-nucleotidase (rats), 489effect upon respiration and yen-
tilation, interaction withmethadone (dogs), 278
relaxation of vascular smoothmuscle by (rats, baboons,dogs, pigs, cats), 26
Thiamine, deficiency, impairmentof behavior and acetylcholinemetabolism in (rats), 537
1-Thiocarbamoyl-2-imidazolidi-
none, formation from nirida-zole in intestine (mice), 363
Thioridazine, comparison of in vi-
tro potency at dopaminergic,alpha adrenergic and mus-
carmnic cholinergic receptorbinding sites (sheep, rats), 81
Thromboxane, release from heartduring hypersensitivity reac-
tions in vitro (guinea pigs),157
Thurman, R. G., see Reinke, L.A., 863
Thyrotropin-releasing hormone,
antagonism of neurotensin-induced antinociception(mice), 645
Tissues
concentration of Na�,K�-aden-osine triphosphatase in heart(guinea pigs), 701
fetal, p-chloro-N-methylani-
lane demethylase activity in(man, chicks), 572
oral, effect of ethanol on testos-terone-5a-reductase in (rats),411
respiratory, response and son-sitivity to histamine, effectsof cyclooxygenase and lipoxy-genase inhibition (guineapigs), 592
Tobramycin, inactivation by azlo-dim, carbenicillin, mecilli-nam, mezlocillin and pipera-cillin (man), 345
Tolerance, to prazosin, involve-ment of renin-angiotensinsystem (rats), 397
Toxicity (see also cytotoxicity)bleomycin, biochemical mark-
ens of (rabbits), 524digitalis, effect of canrenone
(guinea pigs), 784
Trachea, alpha-i and alpha-2 ad-renergic receptors in (dogs),530
Tracy, J. W. and Webster, L. T.,Jr.: The formation of 1-thio-carbamoyl-2-imidazolidinone
from niridazole in mouse in-testine, 363
Transmembrane currents, inatria, effect of aprindine on(frogs), 390
Transmission
cholinergic, effects of/3-bungar-otoxin (guinea pigs, rabbits,rats, mice), 505
neuromuscular, in skeletal mus-cle, comparison of effects ofantibiotics on (rats), 369
neuromuscular, postsynaptic
inhibition by trifluoperazine
(chicks, frogs), 44synaptic, in sympathetic gan-
glia, effects of 5-hydroxytryp-tamine (rabbits), 714
Trifluoperazine, postsynaptic in-
hibition of neuromuscular
transmission by (chicks,
frogs), 44
Trimazosin, effects on coronaryand left ventricular dynamics(dogs), 333
Tsuchiya, T., see Terakawa, M.,209
Tyrosine hydroxylase, striate!, ef-fects of y-aminobutynic acid-elevating agents on neurolep-tic-induced activation of(rats), 177
Umans, J. G., see Ling, G. S. F.,147
Undesser, E. K., Schinnick-Gal-
lagher, P. and Gallagher, J.P.: Catecholamine modula-tion ofspinal sympathetic re-flexes, 170
Uptake, pulmonary amine, effectof bleomycin (rabbits), 524
Uremia, pharmacokinetics of dy-phylline elimination in(man), 340
Urine, volume and electrolytes,central effects of morphine,levorphanol, methadone andendorphins (rats), 579
Urquilla, P. R., see Abel, P. W.,430
Utsui, Y., see Masuda, Y., 805
Valentino, R. J., Herling, S.,Woods, J. H., Medzihradsky,F. and Merz, H.: Quaternarynaltrexone: Evidence for the
central mediation of discrim-inative stimulus effects of
narcotic agonists and antag-onists, 652
Vanadate, renal vascular and tu-bular effects of (rats), 406
van Rhee, J. M., see Plomp, G. J.J., 181
Van Vunakis, H., see Goldstein, S.
A., 36Varma, D. R., see Yue, T. L, 776
Vas deferensactions of ciguatoxin in (guinea
pigs), 475role of changes in adrenergic
nerves for development ofcolchicine-induced supersen-sitivity (rats), 516
smooth muscle, Na�-K�-pumpsite (guinea pigs), 692
Vasopressinrelease, angiotensin-induced,
opiate regulation of (rats),630
release, effects of interactionbetween angiotensin and
opioid peptides (rats), 619Vatner, S. F., see Macho, P., 333Veins, effect of hydralazine, in vi-
tro comparison to arteries(man), 204
Ventilation, effect of theophyllineand methadone interactionupon (dogs), 278
Ventricle, left, dynamics, effectsof tnimazosin (dogs), 333
Vittek, J., Gordon, G. G., South-ren, A. L, Rappaport, S. C.,Munnangi, P. R. and Lieber,C. S.: Effect of ethanol intakeon cellular regulation of tes-tosterone-5a-reductase in ratoral tissues, 411
Vogh, B. P. and Doyle, A. S.: Theeffect of carbonic anhydrase
inhibitors and other drugs on
sodium entry to cerebrospi-nal fluid, 51
Waddell, J. E., see Ruffolo, R. R.,Jr., 235
Wainer, B. H., see Killian, A. K.,
820Walker, L. A. and Fr#{246}lich,J. C.:
Dose-dependent stimulation
of renal prostaglandin syn-thesis by deamino-8-D-argi-nine vasopressin in rats withhereditary diabetes insipidus,87
Wang, L H., see Lee, C-S. C., 340Watanabe, Y., see Terakawa, M.,
209Waters, I. W., see Catravas, J. D.,
350WB41O1, alpha-i adrenoceptor
selectivity of (cats, dogs), 467
Webb, R C. and Bohr, D. F.: Re-laxation of vascular smoothmuscle by isoproterenol, di-
butyryl-cyclic AMP andtheophylline, 26
Webster, L. T., Jr., see Tracy, J.W., 363
Wedlund, P., see Patel, I. H., 555Welch, R. M., see Butz, R. F., 602Westfall, D. P., see Abel, P. W.,
430
White, J. M. and Holtzman, S. G.:Three-choice drug discrimi-nation in the rat: Morphine,cyclazocine and saline, 254
Willette, R. N., see Sapru, H. N.,228
Wilson, S. E., see Levin, J. A., 162
Wilson, W. A., see Zbicz, K. L,222
Wise, W. E., see La Morte, W. W.,
638Withdrawal, of ethanol, sponta-
neous hind leg movements(rats), 666
Woods, J. H., see Valentino, R J.,
652
Woodward, J. K., see Cheng, H.C., 121
Woolverton, W. L. and Balster, R.
L.: Effects of combinations ofphencyclidine and pentobar-bital on fixed-interval per-formance in rhesus monkeys,
611
Wurtman, R. J., see Hefti, F., 189Wurzburger, R. J., Miller, R. L.,
Marcum, E. A., Colburn, W.
A. and Spector, S.: A newradioimmunoassay for halo-
peridol: Direct measurementof serum and striatal concen-trations, 757
Xylamine, actions on central nor-adrenergic neurons (rats),
834
Yaden, E. L., see Ruffolo, R. R.,Jr., 235
Yamamoto, S., Akera, T., Kim,D.-H. and Brody, T. M.: Tis-sue concentration of Na�,K�-adenosine tniphosphataseand the positive inotropic ac-tion of ouabain in guinea-pigheart, 701
Yeoh, P. N., see Kao, C. Y., 416Yohimbine, differentiation of
postsynaptic alpha adrener-gic receptors in tissues by(rats), 235
Yoshida, K., see Masuda, Y., 805
Yousefnejad, D., see Shannon, H.E., 379
Yue, T. L. and Varma, D. R.: In-fluence of protein deficiencyon lysosome stabilizing andpaw edema suppressant ac-tivity ofsteroidal and nonste-roidal anti-inflammatoryagents in rats, 776
Zacharov, S. I., see Gilmour, R.G., Jr., 390
Zbicz, K. L. and Wilson, W. A.:Barbiturate enhancement of
spike frequency adaptation inAplysia giant neurons, 222
Zincinhibition of in vitro histamine
release from basophils (man),292
serum concentrations and sei-zures, influence of D-penicil-lamine (baboons), 138
Zipes, D. P., see Gilmour, R. G.,
Jr., 390Zook, T. E. and Strandhoy, J. W.:
Mechanisms of the natri-
uretic and diuretic effects ofprostaglandins F2,,, 674
Zysset, T. and Bircher, J.: Pref-erential reduction of first-pass elimination by ethanol.Model experiments with do-methiazole in the rabbit, 198
the rnostrS
of
cal scienceI
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December (I) Volume3l5 Numberl 1980
F. Drago, G. Gorgone, F. Spina, G. Panissidi,A. Dal Bello, F. Moro, U. Scapagnini : OpiateReceptors in the Rabbit Iris 1
R. F. Bruns: Adenosine Receptor Activation by
Adenine Nucleotides Requires Conversion of theNucleotides to Adenosine 5
V. Koga, H. Downes, S. M.Taylor: Direct andIndirect Actions of Dopamine on Tracheal SmoothMuscle 15
w, Kobinger, 1. Pichler: Relation BetweenCentral Sympathoinhibitory and Peripheral Pre-and Postsynaptic a-Adrenoceptors as Evaluated byDifferent Clonidine-Like Substances in Rats 21
s.J. Publicover, C.J. Duncan: Stimulation ofthe Frequency of MEPPs at the FrogNeuromuscular Junction by Extracellular EGTA29
H. C. Moises, B. J. Hoffer, D. J. Woodward:GABA Facilitation by Noradrenaline Shows
Supersensitivity in Cerebellum after6-Hydroxydopamine 37
T. Ehara, M. Inazawa: Calcium-Dependent SlowAction Potentials in Potassium- DepolarizedGuinea-Pig Ventricular Myocardium Enhanced byBarium Ions 47
M. Kohlhardt, C. Seifert: Inhibition of Vmax of
the Action Potential by Propafenone and ItsVoltage-, Time- and pH-Dependence inMammalian Ventricular Myocardium 55
M. A. Evans : Effects of Anticonvulsants andMethotrexate on Calcium Disposition 63
T. Kishimoto, N. Urakawa : The Inhibitory Effectof Lithium on High-K Induced Contraction inGuinea-Pig Taenia Coli 69
C.J.Duncan, H. C. Greenaway, J. L. Smith:2,4- Dinitrophenol, Lysosomal Breakdown andRapid Myofilament Degradation in VertebrateSkeletal Muscle 77
Short Communications
J. M#{246}hring, J. Schoun, J. Kintz, R. McNeill:Decreased Vasopressin Content in Brain Stem ofRats with Spontaneous Hypertension 83
N. Rohm, J. Wagner, H. J. SchUmann : TheLack of a Pronounced Preference of Prenalterol forthe Beta-i -Adrenoceptor Subtype 85
Indexed in Current Contents
Springer InternationalNaunyn-Schmiedeberg’s Arch. Pharmacol
�- ISSN 0028-1 298 NSAPCC 31 5(1 ) 1 - 88 (1980)