SARC Career Development Award Program
Richard Gorlick, MD
Lee Helman, MD
SARC Career Development Award
Fund established 2007Initial award granted 2009
Incorporated into the SARC sarcoma SPORE in 2013
Purpose• To help prepare and support scientists working
in sarcoma as they begin their careers as independent researchers
SARC Career Development Award
Committee R. Gorlick, Co-Chair L. Helman, Co-Chair J. Crowley J. Fletcher M. Thornton
F. Hornicek D. Lev C. Mackall M. van de Rijn S. Schuetze L. Schwartz
SARC Career Development Program 2014
SARC Sarcoma SPORE Career Development AwardRequires awardees to be US citizens
SARC is interested in continued support of researchers internationally
Two funding opportunitiesUS based researcher International researcher
SARC SPORE CDA
CriteriaFinal year of clinical fellowship or postdoctoral
fellowship, or within five years of first faculty appointment
Demonstrated track record of interest and productivity in research relevant to sarcoma
US citizenFunding Level
$100,000 per year, for up to two years
International CDA
CriteriaFinal year of clinical fellowship or postdoctoral
fellowship, or within five years of first faculty appointment
Demonstrated track record of interest and productivity in research relevant to sarcoma
Citizenship outside USFunding Level
$100,000 per year, for up to two years
Application Process
Two step processLetter of IntentFull application
Letter of intent dueJanuary 3, 2014
Contact SARC with any [email protected]
2009 Career Development Award Recipients
• Anchorage-independent conditions as a model for micrometastatic disease in osteosarcoma
• Targeted therapy of Ewing’s Sarcoma via IGF-1R signaling cascade
Sandra Strauss, MD, PhDUniversity College London
Joseph Ludwig, MDUniversity of Texas, MD Anderson
Cancer Center
2010 Career Development Award Recipients
• Novel genomic approach to risk-stratify and identify relapse-associated copy number alterations in Ewing’s sarcoma
Patrick J. Grohar, MD, PhDFellow, National Cancer Institute
• Development of a Small Molecule Therapy Targeting EWS-FLI1
Joshua D. Schiffman, MDAssistant Professor, University of Utah
2011 Career Development Award Recipients
• Adoptive T-cell therapy for patients with metastatic sarcoma
Keila Enitt Torres, MD, PhDUniversity of Texas, MD Anderson
Cancer Center• The role of the
P13K/AKT/mTOR pathway in radiation associated sarcoma (RAS)
Seth M. Pollack, MDUniversity of Washington/Fred
Hutchinson Cancer Research Center
2012 Career Development Award Recipients
• Exploiting Argininosuccinate Synthase 1 Deficiency in Sarcoma.
Adrián Mariño-Enríquez, MD Harvard Medical School, Brigham and
Women’s Hospital, Department of Pathology
• Genome-wide functional characterization of GIST: Strategies to maximize kinase-inhibitor response
Brian A. Van Tine, MD, PhDWashington University, Division of Medical Oncology Director, and Assistant Professor,
Division of Medical Oncology
2013 Career Development Award Recipients
Simone Hettmer, MD,Dana Farber Cancer Institute
Cigall Kadoch, PhDBroad Institute
John Shern, MDNational Cancer Institute
• Identifying novel therapies in pediatric RMS using high-throughput screening for inhibitors of the PAX3-FOX01 Oncogenic transcription factor
• Evaluation of the contributions of candidate RMS-relevant genes/pathways in RMS malignancy
• Reversing the roles of misdirected chromatin remodeling in human synovial sarcoma
2014 Career Development Application Key Dates
January 3, 2014Letter of Intent
March 31, 2014Submission of Grant Proposal
July 1, 2013Funding Period Begins