Supplemental Data
A single ancient origin for prototypical SR splicing factors
Sophie Califice, Denis Baurain¶, Marc Hanikenne and Patrick Motte¶
¶To whom correspondence should be addressed.
E-mail: [email protected], [email protected]
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Table of contents
Supplemental Texts
Text S1. Detailed description of computational procedures. 4
Supplemental Table Legends. 17
Supplemental Figure Legends. 19
Supplemental References. 28
Supplemental Tables
Table S1. Taxonomic distribution of RRM-containing proteins. Table S1 File
Table S2. Hand-curated corpus of RRM-containing proteins collected in the primary literature. 30
Table S3. Qualitative comparison of the five large RRM domain trees. 56
Table S4. Summary of the groupings observed for SR protein RRM1 domains. 58
Table S5. Compositional features specific of one or more SR subfamilies. 59
Table S6. Determination key for SR families and subfamilies. 60
Table S7. Statistics for the curated inventory of SR proteins in 20 selected proteomes. 61
Supplemental Figures
Figure S1. Scheme of the analysis pipeline. 62
Figure S2. Optimization of clustering parameters for RRM domains. 63
Figure S3. Evaluation of the selection algorithm for cluster representatives. 68
Figure S4. Color key for KOG annotation. 69
Figure S5. Maximum Parsimony tree of representative RRM domains. 70
Figure S6. RAXML tree of representative RRM domains obtained under the WAG+Γ4 model. 81
Figure S7. TREEFINDER tree of representative RRM domains obtained under the WAG+Γ4 model. 92
Figure S8. RAXML tree of representative RRM domains obtained under the LG+F+Γ4 model. 103
Figure S9. RAXML tree of the enlarged RRM dataset obtained under the WAG+Γ4 model. 114
Figure S10. Qualitative consensus of phylogenetic analyses of representative RRM domains. 130
Figure S11. Mutual affinities of SR protein RRM domains in the five large trees. 131
Figure S12. RAXML tree of the largest RRM clusters obtained under the LG+F+Γ4 model. 132
Figure S13. Exhaustive RAXML tree of SR-associated RRM1 domains (WAG+Γ4 model). 133
Figure S14. Exhaustive TREEFINDER tree of SR-associated RRM1 domains (WAG+Γ4 model). 137
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Figure S15. RAXML tree of RRM1 domains from RNPS1-like proteins (WAG+Γ4 model). 141
Figure S16. TREEFINDER tree of RRM1 domains from RNPS1-like proteins (WAG+Γ4 model). 142
Figure S17. RAXML tree of RRM2 domains from dual RRM SR proteins (WAG+Γ4 model). 143
Figure S18. TREEFINDER tree of RRM2 domains from dual RRM SR proteins (WAG+Γ4 model). 147
Figure S19. RAXML tree of slowly evolving SR-associated RRM1 domains (WAG+Γ4 model). 151
Figure S20. TREEFINDER tree of slowly evolving SR-associated RRM1 domains (WAG+Γ4 model). 154
Figure S21. Sequence conservation in the first RRM domain of SR proteins. 157
Figure S22. Sequence conservation across prokaryotic RRM domains. 161
Figure S23. Sequence conservation across ZnK domains of SR proteins. 162
Figure S24. Distributions of relevant compositional features within SR subfamilies. 163
Figure S25. Architecture, conservation and compositional profile of SR subfamilies. 173
Figure S26. RAXML RRM tree of candidate SR proteins from selected proteomes (WAG+Γ4 model). 175
Figure S27. TREEFINDER RRM tree of candidate SR proteins from selected proteomes (WAG+Γ4 model). 178
Figure S28. RAXML tree of candidate SR proteins from selected proteomes (LG+F+Γ4 model). 181
Figure S29. PHYLOBAYES tree of candidate SR proteins from selected proteomes (CAT+Γ4 model). 184
Datasets
Dataset S1. HMM profiles for SR-associated RRM domains. Dataset S1 File
Dataset S2. Accessions and sequences of SR proteins identified in the inventory. Dataset S2 File
Dataset S3a. Architectures of candidate SR proteins from selected proteomes. Dataset S3 File
Dataset S3b. 1-AA word densities in candidate SR proteins from selected proteomes. Dataset S3 File
Dataset S3c. 2-AA word densities in candidate SR proteins from selected proteomes. Dataset S3 File
Dataset S3d. 3-AA word densities in candidate SR proteins from selected proteomes. Dataset S3 File
Dataset S4. Alignments in FASTA format. Dataset S4 File
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Text S1. Detailed description of computational procedures
1. RRM distribution across the Tree of Life
1.1. Data downloads
All complete prokaryotic and eukaryotic proteomes available on Ensembl and NCBI FTP servers
were downloaded in November 2007 (http://www.ncbi.nlm.nih.gov/sites/genome/). Additional
complete proteomes from photosynthetic eukaryotes were downloaded from JGI (Aureococcus
anophagefferens, Chlamydomonas reinhardtii, Ostreococcus lucimarinus, Ostreococcus tauri,
Phaeodactylum tricornutum, Physcomitrella patens, Phytophthora ramorum, Phytophthora
sojae, Thalassiosira pseudonana, and Volvox carteri; http://genome.jgi-psf.org/) and TIGR
(Ricinus communis and Zea mays; now located at http://cmr.jcvi.org/) servers. Cyanidioschyzon
merolae and Medicago truncatula complete proteomes were downloaded from their respective
project websites (http://merolae.biol.s.u-tokyo.ac.jp/ and http://medicago.org/).
1.2. Prediction of RRM domains
The PFAM (Finn et al., 2010) alignment for the RRM domain (pfam00076; 79 domain
sequences from 57 proteins) was downloaded from the NCBI Conserved Domain Database
(CDD) (Marchler-Bauer et al., 2009) and used to build a HMM profile with the HMMBUILD
component of the HMMER software package (http://hmmer.org/, see also Durbin et al., 1998).
As mentioned on the PFAM website (http://pfam.sanger.ac.uk/ family?acc=PF00076), the C-
terminal β-strand and final helix are hard to align and have been omitted in the seed alignment,
thus yielding a 72-amino-acid (AA) profile slightly truncated relative to the complete RRM
structure. RRM domains were predicted in each complete proteome with the program
HMMSEARCH (HMMER) using the HMM profile and a loose domain E-value threshold of 1e-5.
1.3. Extraction of RRM domains and RRM-containing proteins
HMMER reports were parsed to extract both the predicted RRM domains and the corresponding
full-length proteins in FASTA format. To determine the best domain E-value threshold,
sequences were repeatedly extracted using five increasingly stringent thresholds (1e-5, 1e-10,
1e-15, 1e-20, and 1e-25). Eventually, the threshold was set to 1e-10 as this value appeared to
give the best compromise between sensitivity and specificity. RRM domains were numbered
according to their N-term relative position within each protein (e.g., the second RRM domain of
any given protein is numbered RRM2). Consequently, RRM domains located downstream of at
least one unpredicted RRM domain (owing to an evolutionarily divergent sequence) were
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assigned an incorrect number. This shortcoming was taken into account during annotation and
manual analyses of RRM trees (see Sections 2.4-2.5). Finally, proteins containing more than one
predicted RRM were extracted only once to ensure accurate statistics.
1.4. Prediction of putative SR proteins
Extracted RRM-containing proteins were tagged as 'putative SR' when they met the rather crude
criterion proposed in reference (Boucher et al., 2001), i.e., having at least one occurrence of
either quadripeptide 'RSRS' or 'SRSR'. Tagging was carried out for annotation purposes only;
thus the absence of the 'SR' tag was never used to exclude a protein from subsequent analyses.
For Figure 1C, RS/SR dipeptides were counted either in the complete dataset of non-redundant
8,042 RRM-containing proteins or in a subset of 197 proteins displaying at least 95% identity to
reference sequences confirmed as SR or SRrp proteins (see Table S2 below for details).
1.5. Taxonomic distribution of RRM-containing proteins
For each domain E-value threshold, the numbers of RRM domains, RRM-containing proteins
and putative SR proteins predicted in each complete proteome were compiled, along with
proteome size and lineage, as fetched from the NCBI Taxonomy server (Benson et al., 2009;
Sayers et al., 2009). Proteomes were further categorized according to domain (Archaea,
Bacteria, or Eukaryota), complexity (unicellular vs. multicellular) and metabolism (standard vs.
capable of oxygenic photosynthesis) and the influence of these factors was assessed using F-
tests performed with the R statistical software (R Development Core Team, 2010). Though all
eukaryotic and 126 prokaryotic proteomes yielded at least a few RRM-containing proteins, most
prokaryotic and viral proteomes appeared devoid of RRM domains (Figure 1A-B and Table S1).
These were nevertheless included for completeness.
2. Origin and evolution of SR proteins
2.1. Clustering of RRM domains
To allow phylogenetic analyses, the large number of RRM domains extracted in Section 1.3
(12,023 at the 1e-10 threshold) was reduced to a more tractable dataset through a two-step
clustering based on sequence similarity.
First, exactly identical domains were consolidated and renamed after the most inclusive
taxonomic group of each cluster members (e.g., a RRM domain found in both Mus musculus
and Rattus norvegicus proteomes would be renamed 'Murinae'). Most of the time, merged
domains corresponded to orthologues of closely related organisms or to in-paralogues (i.e.,
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terminal gene duplications specific to an organism or to a small clade) or to protein isoforms.
This step roughly reduced the number of RRM domains by 50% (6,633 at the 1e-10 threshold).
Second, these unique RRM domains were more aggressively clustered by single-linkage using
the (now deprecated) BLASTCLUST component of the NCBI C toolkit (Altschul et al., 1997). Two
main parameters control the granularity of the clustering: these are the similarity threshold
(fraction of identical residues in the local pairwise alignment) and the coverage threshold
(fraction of the longest sequence covered by the alignment) that are to be reached to consider
two domains as neighbors. To ensure the best clustering (Ck), we explored the parameter space
for both thresholds (by steps of 0.05) and chose the combination of values that maximized a
composite score rewarding normalized entropy (Cover and Thomas, 2006) but penalizing the
number of singleton clusters (i.e., having only one domain) :
Sc =H(Ck )
logK− 0.8
N1
N
where
H(Ck ) = −Nk
Nk=1
K
∑ logNk
N
with N = total number of domains
K = number of clusters
Nk = number of domains in cluster k
N1 = number of singleton clusters
As shown in Figure S2, optimal parameters were as follow: similarity threshold = 0.60 and
coverage threshold = 0.85. These values held for domain E-value thresholds ranging from 1e-5
to 1e-20 and this step further reduced the cluster number by 80% (down to 1266 at the 1e-10
threshold). In the clustered datasets, each cluster was represented by the sequence of one of its
domains and names were attributed as in the first step, albeit often resulting into much higher
level taxa (e.g., Viridiplantae, Eukaryota, cellular organisms).
By default, BLASTCLUST selects the longest sequence as the cluster representative. Since longer
sequences are also more prone to be evolutionarily divergent (due to the accumulation of non-
conserved insertions), we modified BLASTCLUST to instead allow the selection of the most
slowly evolving cluster sequence. In practice, for each cluster, the domain showing the highest
average similarity with non-cluster domains was selected as the cluster representative. Our
algorithm is an independent re-implementation of the approach used in the SCAFOS software
package (Roure et al., 2007). The usefulness of this modification was evaluated by comparing
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the length of the phylogenetic trees inferred by parsimony (see Section 2.3 for details) from
three alternative datasets based on the selection strategy applied: (i) longest sequence; (ii) most
slowly evolving sequence; (iii) fastest-evolving sequence (control experiment). Out of 1266
clusters, there were 352 differences when comparing cluster representatives between strategy (i)
and (ii); 299 between (i) and (iii); and 479 between (ii) and (iii). In terms of performance, Figure
S3 shows that strategy (ii) generally yielded the shortest trees, followed by strategies (i) and (iii).
These results indicate that our algorithmic modification to BLASTCLUST should help to reduce
the occurrence of phylogenetic artifacts by actively avoiding the selection of evolutionarily
divergent sequences.
In the following, the 1266-cluster dataset built by selection of the most slowly evolving RRM
domains was used as the basis of all analyses.
2.2. Alignment of RRM domains
Due to weak conservation combined to a large number of RRM domains to consider, standard
alignment methods (e.g., CLUSTALW) led to overly wide alignments with so many gaps that they
were practically unusable (data not shown). Alternatively, RRM domains were aligned with
HMMALIGN (HMMER) against the HMM profile already used for their prediction (see Section
1.2). To control alignment width, amino acids that did not align to match states of the profile
were discarded (option -m), thus literally 'splicing' autapomorphic (and unalignable) insertions
out of longer domain sequences. Consequently, the resulting alignment had only 72 AA
positions, as many as the HMM profile. Visual inspection of the 1266 domain sequences
indicated that this alignment was suitable for large-scale analyses.
2.3. Phylogenetic analyses of RRM domains
The large alignment of RRM domains was analysed by Maximum Parsimony (MP) using PAUP*
(Swofford, 2002) (Figure S5) and by Maximum Likelihood (ML) using either TREEFINDER (Jobb et
al., 2004) with a WAG+Γ4 model (Yang, 1993; Whelan and Goldman, 2001) (Figure S7) or
RAXML with the very similar PROTMIXWAG model (Stamatakis et al., 2005) (Figure S6) or with
the LG+F+Γ4 model (Le and Gascuel, 2008) (Figure S8). SEQBOOT and CONSENSE from the
PHYLIP software package (Felsenstein, 2005) were used respectively to generate 100 bootstrap
replicates (Felsenstein, 1985) for each analysis and to compute support values. Bayesian
inference with the CAT model known to reduce phylogenetic artifacts (Lartillot and Philippe,
2004; Lartillot et al., 2009; Philippe et al., 2011) was also investigated. However, this
sophisticated model designed for phylogenomics did not yield useful results on our sequence-
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rich but position-poor dataset, even after having run two independent PHYLOBAYES chains for
more than 85,000 cycles (data not shown).
To evaluate our selection algorithm for representative cluster sequences (see Section 2.1) in a
reasonable time, PAUP* was invoked with the following options: NREPS=1;
ADDSEQ=RANDOM; SWAP=TBR; MAXTREE=10. In contrast, the tree built for phylogenetic
purposes was inferred using more time-consuming options: NREPS=10; ADDSEQ=RANDOM;
SWAP=TBR; MAXTREE=1000. As a consequence, the latter MP tree (Figure S5; 36,439
parsimony steps) was slightly shorter than the former (Figure S3; 36,617 parsimony steps).
Trees were rooted and left-ladderized using the TREEPLOT component of the MUST software
package (Philippe, 1993). Since prokaryotic (and prokaryotic-containing) clusters were mostly
concentrated in a small region of the tree, the root was set on the branch separating the bulk of
these predominantly prokaryotic clusters from eukaryote-specific clusters. Automatic
ladderization based on subtree content helped to order branches so that similarly composed
subtrees were easily recognizable by eye across analyses.
2.4. Annotation of RRM trees
Prior to manual examination, RRM trees were automatically annotated using several data
sources. To maximize the sensitivity, annotation was actually performed on the individual
proteins corresponding to the RRM domains clustered in the trees. Thus, the main challenge
was to keep track of the relationships between individual RRM domains (12,023) and RRM-
containing proteins (8,042) on one side and cluster representative RRM domains (1266) on the
other side, especially considering the two-step clustering and the taxonomic renaming of
cluster representatives (see Section 2.1). Another challenge was to efficiently summarize the
annotation of potentially numerous domains on the single tree leaf corresponding to each
cluster representative. This was addressed by adding to leaf labels all annotation pieces that
qualified at least 5% of cluster members, ordered by relevance within each data source. In
addition to this relative measurement, stretches of stars ('*') growing with the natural logarithm
of the absolute number of domains qualified by each annotation piece were included. Finally,
the color code of the most relevant (i.e., with the highest percentage) KOG annotation (see next
paragraph and Figure S4) was applied to all labels for which the information was available.
Altogether, this considerably facilitated visual comparison of the trees.
Two main data sources were used for annotation: (i) the KOG (Tatusov et al., 2003) component
of NCBI CDD and (ii) a hand-curated corpus of about 500 RRM-containing proteins collected
in the primary literature (Table S2). In preliminary experiments, other components (SMART,
PFAM, COG, and PRK) of NCBI CDD were evaluated, but KOG was ultimately selected as the
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most complete source. KOG was mined using RPS-BLAST (a variant of PSI-BLAST) (Altschul et
al., 1997) with an E-value threshold of 1e-10, whereas reference proteins were searched using
BLASTP (or TBLASTN for reference mRNAs) with an identity threshold of 75%. More stringent
thresholds (respectively 1e-25 and 95%) were also considered but eventually abandoned due to
a general lack of sensitivity that left most leafs without annotation. The flip side of adopting
such a sensitive approach was a potential lack of specificity. That is why we took the resulting
annotation with a grain of salt when analyzing the trees.
Other annotation bits added to leaf labels included: (iii) the number of domains in the cluster;
(iv) the distribution of RRM numbers in the cluster (see Section 1.3 for the caveat about
unpredicted RRM domains); (v) the amount of prokaryotic proteins; and (vi) the amount of
'putative SR' proteins. Notably, all annotation also applied to singleton clusters, except that
numbers were dropped for simplicity. Furthermore, the following typographical conventions
were enforced: (vii) prokaryotic-containing clusters in italic and (viii) clusters with domains
from more than one species in boldface.
2.5. Analyses of an enlarged RRM dataset
Phylogenetic accuracy is known to be difficult to achieve. Consequently, robustness of
phylogenetic inference is often assessed by analyzing the same alignment with multiple
reconstruction methods and/or evolutionary models. Orthogonal to this approach, it is possible
to enlarge or reduce the set of sequences included in the alignment. Experience has indeed
shown that varying 'taxon sampling' is very efficient at uncovering phylogenetic artifacts (for
reviews, see Delsuc et al., 2005; Philippe et al., 2005; Philippe et al., 2011). Here, both
strategies were used to generate five different large RRM trees that were carefully compared to
test the hypothesis of a single origin for SR splicing factors (see Section 2.6). As stated in Section
2.3, the first four trees (Figures S5-8) were inferred from the same 1266-cluster alignment. The
purpose of this section is to explain how we assembled the huge alignment used for the fifth
(even larger) tree (Figure S9).
As an alternative to complete proteomes used throughout this study, two other protein
databases were mined for RRM domains: (i) NCBI RefSeq release 26 (Pruitt et al., 2007) and (ii)
SMART 6 (Letunic et al., 2009). While RefSeq proteins were processed exactly as in Sections
1.2-1.3 (using the HMM profile for prediction), RRM domains and RRM-containing proteins
were directly downloaded through the batch interface of the SMART website (http://smart.embl-
heidelberg.de/). In both cases, the usual 1e-10 domain E-value threshold was used for
extraction, which respectively yielded 10,739 and 9,978 RRM domains (see Table S1 for
taxonomic distributions).
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RRM domains from all three sources (including complete proteomes) were then merged into
one huge (yet overlapping) dataset and clustered using the same parameter values as in Section
2.1 to give a non-redundant dataset of 1831 clusters (to be compared to the 1266 clusters of
complete proteomes alone). Automated alignment with HMMALIGN resulted in an alignment that
had again 72 AA positions and that was analyzed using RAXML with the WAG+Γ4 model.
Finally, the tree was rooted on most prokaryotic domains, left-ladderized and annotated, even if
its assembly from multiple sources made the process more difficult.
2.6. Comparison of large RRM trees and phylogenetic analysis of the largest RRM clusters
The overall congruence of the large RRM trees was manually assessed by taking advantage of
the multiple annotation pieces described in Section 2.4. The primary criterion was the KOG
color coding, along with matches to RRM-containing reference proteins. The RRM number was
also heavily used for proteins with multiple (up to six) RRM domains. For practical reasons, we
mainly focused on leafs (clusters) representing a large number of RRM domains and/or
including matches to reference RRM-containing proteins. When comparing the five different
trees, two types of issues pertaining to RRM associations were examined: (i) do proteins from a
given KOG consistently group together? and (ii) do different KOG consistently group together?
These analyses allowed us to identify 88 groupings that were generally stable across the trees
(Table S3). Associations between these groupings are summarized in a qualitative consensus
tree (Figure S10). Altogether, mutual affitinities among groups of SR-associated RRM domains
suggested that most SR proteins share a single origin (Figure S11 and Table S4).
To check that SR proteins indeed derive from a common ancestor, an additional ML tree
focusing on the 152 largest multi-species RRM clusters was computed using RAXML with the
LG+F+Γ4 model (Figures 2 and S12). Briefly, the 1266-cluster RRM alignment was filtered to
discard sequences that did not represent at least 8 RRM domains. We also removed 5 more
sequences that represented larger RRM clusters, of which sequences all came from a single
species, as these corresponded to multiple in-paralogues and/or mis-predicted proteins:
Caenorhabditis@F42A6_7a_1_RRM_2, (8 domains), Caenorhabditis@Y46G5A_13_RRM_3
(10), Caenorhabditis@Y73B6BL_6a_3_RRM_2 (10), Caenorhabditis@Y73B6BL_6b_3_RRM_1
(10), and Danio @ENSDARP00000091192_RRM_1 (14). Therefore, the 152 retained sequences
represented 10,101 of the 12,023 originally retrieved RRM domains (84%). Strikingly, in this
sparser yet still unbiased tree, the RRM1 domains of most SR proteins were resolved as a single
clade, while the global phylogenetic resolution was much improved (Figures 2 and S12). This
result greatly strengthened our confidence in a single origin of main SR protein architectures.
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2.7. Phylogenetic analyses of SR-associated RRM domains
To analyze the subsequent evolution of SR proteins, we decided to focus on three subtrees
(shown in pink in Figure S6). For each subtree, RRM domains hidden behind each leaf were
extracted from the 6,633-cluster dataset obtained after the first clustering step (see Section 2.1).
Starting from this non-redundant dataset allowed us to greatly refine our sampling and to
discard any potential mis-clustering caused by the greedy single linkage algorithm of
BLASTCLUST, while ensuring that no duplicate domains were included. RRM domains were
anew aligned using the HMM profile but this time without discarding insertions to preserve as
much phylogenetic information as possible. The resulting alignments were cursorily optimized
by hand using the interactive editor ED (MUST) then analyzed by ML using both TREEFINDER and
RAXML with the WAG+Γ4 model, yielding six small RRM trees (Figures S13-18) out of three
datasets. After automatic annotation as already described, the trees computed from the RRM1 of
SR45/RNPS1 proteins (42 domains x 73 AA; Figures S15-16) and from the RRM2 of dual RRM
SR proteins (349 domains x 97 AA; Figures S17-18) were directly interpretable, whereas the
poor phylogenetic resolution of those inferred from the RRM1 of SR proteins (434 domains x 93
AA; Figures S13-14) prompted us to experiment with variations in taxon sampling.
In a first variant, we removed 130 fast-evolving domains (i.e., having long branches in the trees)
to reduce the occurrence of phylogenetic artifacts, which helps to improve resolution. The two
trees inferred from this curated dataset (304 domains x 87 AA) are shown in Figures S19-20.
Then, we produced three more variants of this curated dataset by removing domains either from
RS proteins (292 domains x 85 AA) or from dual ZnK SR proteins (297 domains x 87 AA) or
from both subfamilies at the same time (285 domains x 85 AA). The trees obtained from these
additional datasets are not shown but were used to monitor the effect of alternative samplings
on the phylogenetic resolution of the relationships among the remaining SR-protein families
and subfamilies (Table 1).
Along with RRM1/RRM2 and ZnK sequence logos (see Section 3.2), thorough comparison and
integration of 5 (+1) large and 14 small RRM trees (see Section 4.2 for 4 more small trees)
together laid the basis of our scenario for the single origin and subsequent diversification of SR
proteins into 4 natural families (Figures 2-3 and S10-11 and Tables 1 and S3-4).
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3. Profiling of sequence features in SR families
3.1. Extraction of RRM domains of SR-protein subfamilies
Based on the curated RAXML tree of SR-associated RRM domains (Figure S19), RRM1 domain
sequences corresponding to each SR-protein subfamily were extracted from the initial 12,023-
domain dataset (see Figure 3 for an up-to-date nomenclature). Subfamilies defined in this tree
were (i) SC35; (ii); SCL; (iii) SRrp; (iv) 9G8; (v) SRp20; (vi) RSZ; (vii) RS2Z; (viii) animal ASF-like;
(ix) plant ASF-like; (x) SRp40-55-75; and (xi) RS. Similarly, the two remaining small RAXML
trees were used to extract the RRM1 of (xii) SR45 and of (xiii) RNPS1 (Figure S15), as well as the
RRM2 of animal ASF-like and of SRp40-55-75 (Figure S17). Owing to its evolutionary
divergence, the RRM2 of the RS family had to be extracted from the large RAXML/WAG tree
inferred from complete proteomes (Figure S6). Furthermore, to complete our subfamily-specific
RRM domain datasets, the missed RRM2 of the plant ASF-like subfamily was predicted anew
using a very loose domain E-value threshold (0.1) directly on the corresponding proteins.
As explained in the main text, the RRM of human SRp54 was also too divergent to be detected
by the universal HMM profile. This SR protein was thus not investigated in our study as it
would have featured a very long branch prone to phylogenetic artifacts. To complicate matters,
the official SRP54 symbol actually corresponds to another protein, the signal recognition
particle 54 kDa (ENSG00000100883), which is a ribonucleoprotein belonging to the GTP-
binding SRP family and devoid of RRM domain... yet interacting with RNPS1! See
http://www.uniprot.org/uniprot/P61011 for details.
3.2. Sequence logos of aligned RRM and ZnK domains of SR-protein subfamilies
Within each subfamily, RRM1 domains were carefully aligned with ED (MUST) using the
secondary structure as a guide. To improve alignments, minor domain-specific insertions (1-2
AA) were occasionally spliced out, while a handful of divergent domains were excluded. Then,
RRM2 domains from dual RRM SR subfamilies were separately aligned. Finally, subfamilies
were aligned with each other based on their consensus sequences to yield a high-quality
structural alignment including RRM1 and RRM2 domains from all SR-protein subfamilies. Using
different excerpts of this alignment, sequence logos (Schneider and Stephens, 1990) for each
subfamily (Figure 4; see also Figure S21) were computed with WEBLOGO (Crooks et al., 2004)
after enabling the correction for small samples.
Two overlapping strategies were used to sample prokaryotic RRM domains: (i) either all
prokaryotic domains found in the initial dataset or (ii) only those located in the mainly
prokaryotic subtrees used to root the large RAXML/WAG tree (Figure S6). The resulting
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prokaryotic RRM datasets (cleared of potential eukaryotic contaminants) were processed as SR-
protein subfamilies to generate the corresponding sequence logos (Figure S22).
To predict ZnK domains, a HMM profile was built from the PFAM alignment for the zf-CCHC
domain (pfam00098; 182 domain sequences from 109 proteins). As for RRM domains before,
ZnK domains were predicted in all complete proteomes. However, only those corresponding to
single RRM ZnK-like SR subfamilies were actually extracted, thus resulting in four small
datasets: 9G8, RSZ, RS2Z (left) and RS2Z (right). To increase the sampling for RSZ and RS2Z,
ZnK domains from SR proteins identified in the inventory of additional proteomes (see Sections
4.1-4.4) were also included. Alignments and logos were easy to obtain due to the apparent
constraint on size characterizing these domains (Figure S23).
3.3. Profiling of compositional features in SR-protein subfamilies
Full-length proteins corresponding to subfamily datasets used for RRM logos were collected and
submitted to blind compositional analyses. First, a 24-AA sliding window was moved (1 AA at a
time) along every individual protein. At each step, the numbers of occurrences for all possible
overlapping unordered words of size 1 to 3 AA were recorded. Unordered means that
occurrences of, e.g., SR and RS dipeptides were consolidated, while overlapping means that,
e.g., the SRR tripeptide was counted as either (i) 1xS and 2xR or (ii) 1xRS/SR and 1xRR or (iii)
1xRRS/RSR/SRR, depending on word size. These word densities were then plotted for all
proteins of each subfamily (data not shown, but see Dataset S3b-d for an illustration of a similar
procedure). To avoid unnecessary clutter, density curves that did not reach a predefined
threshold (1 AA: 8; 2-3 AA: 6) for any protein within a subfamily were discarded. After visual
inspection of the resulting graphs, a series of words were identified as potentially useful for
discriminating the different SR subfamilies (Table S5). Second, this preselection was refined by
comparing the distribution (across all proteins of a given subfamily) of each word between
subfamilies. Since we were mostly interested in inter-domain compositional features, promising
words were tracked in particular protein regions: (i) before the first domain; (ii) between the first
and the second domain; and (iii) after the last domain. This process led to one graph per
word/region combination, each displaying the distribution of the compositional feature in every
SR subfamily (Figure S24). Third, one representative protein was selected out of each subfamily,
except for SRp40-55-75 and animal ASF-like, from which were selected three (SRp40, SRp55,
SRp75) and two (ASF/SF2 and SRp30c) representatives, respectively. These proteins were used
to graphically summarize the results of the compositional profiling (Figures 5 and S25).
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3.4. Profiling of conservation in SR-protein subfamilies
The same full-length protein datasets were automatically aligned with CLUSTALW (Thompson et
al., 1994). Alignments were then analyzed with the program PLOTCON (EMBOSS software
package, Rice et al., 2000) to profile sequence conservation in every subfamily. Briefly,
conservation along aligned proteins was computed by averaging all possible pairwise scores
(using the EBLOSUM62 similarity matrix) at each position within a 24-AA sliding window. To
allow a perfect juxtaposition with composition profiles, subfamily alignments were first cleared
of sequence insertions relative to the representative proteins selected in Section 3.3. In practice,
columns corresponding to positions missing in these proteins were removed from the
alignments using the program NET (MUST), which implies that, for each subfamily, PLOTCON
actually analyzed an alignment of exactly the same length as the protein representing the
subfamily (Figures 5 and S25).
3.5. Development of a determination key for classifying SR proteins
To help classifying uncharacterized SR proteins, a determination key was developed by
integrating most of our analyses: (i) protein architecture; (ii) conserved motifs in RRM domains;
and (iii) compositional features (Table S6). This key was validated on candidate SR proteins
identified in Sections 4.1-4.4.
4. Inventory of SR proteins in selected organisms
4.1. Optimized prediction of SR-associated RRM1 domains
Our original HMM profile for the RRM domain was deliberately universal in order to sample as
much functional diversity as possible. This allowed us to investigate the origin and evolution of
SR proteins using the ubiquitous RRM domain as a proxy for whole proteins. However, for
uncharacterized proteomes, directly predicting domains that belong to SR proteins is more
advantageous. To this end, six new HMM profiles optimized for the prediction of SR-associated
RRM1 domains were computed from our alignments. The first three profiles were built from two
sequence-rich but automatically HMM-aligned RRM1 subtrees (Figures S12,14; outgroups
excluded), whereas the three remaining profiles were derived from RRM1 sequence logos
(Figure S21), which had been structurally aligned by hand but lacked fast-evolving sequences.
These six new profiles were then tested on 20 selected proteomes: 13 model organisms already
used in the previous analyses and 7 recently sequenced photosynthetic species (downloaded in
June 2009; see Tables 2 and S7 for species list). HMMSEARCH was run with the same loose
domain E-value threshold as in Section 1.2 (1e-5) but each HMMER report (6 x 20 = 120) was
14
individually examined to determine the optimal threshold. In practice, we set the threshold in
the valley between the best hits (normally derived from SR proteins) and the remaining (non-SR)
hits. For most reports, this task was rather easy to perform as the valley was unambiguous
(except for Aspergillus fumigatus that did not yield any obvious SR-associated RRM1 domain).
After consolidation of duplicates (i.e., predicted by more than one profile), a total of 247
candidate SR proteins were retained out of 19 proteomes.
4.2. Phylogenetic analyses of candidate SR protein RRM domains
RRM1 (and RRM2) domains from candidate SR proteins were extracted and automatically
aligned on our structural alignment of SR-protein subfamily consensus sequences (see Section
3.2). This was carried out with the BABA component of the MUST software package, which also
affiliated each candidate RRM domain to the most appropriate SR-protein subfamily.
The resulting high-quality alignment was then analyzed as in Section 2.3 (with both TREEFINDER
and RAXML heuristics, as well as with PHYLOBAYES). Again, different variants of the dataset
were considered: (i) with or without RRM2 domains; (ii) including or excluding positions
corresponding to subfamily-specific insertions. Finally, we settled on a dataset containing all
SR-associated RRM1 domains, along with RRM2 domains from plant RS proteins to test the
duplication hypothesis (see main text), but no outgroup domains to minimize phylogenetic
artifacts (Philippe et al., 2011). The trees, which eventually excluded subfamily-specific
insertions, were rooted on the SR45/RNPS1 RRM domains (for convenience) and automatically
annotated (Figures S26-29; see also Table 1 for the phylogenetic resolution of relationships
among SR-protein families and subfamilies).
4.3. Architectural and compositional analyses of candidate SR proteins
The architecture of every candidate SR protein was elucidated by scripting the NCBI Conserved
Domain Database web server (http://www.ncbi.nlm.nih.gov/cdd/). Consequently, domain
identification was not restricted to RRM and ZnK domains but took advantage of the full
breadth of domains available in CDD (Dataset S3a).
In parallel, candidate SR proteins were submitted to the blind compositional analyses already
described, except that all candidate SR proteins were processed at the same time, rather than
subfamily by subfamily as when selecting discriminating features (Dataset S3b-d).
15
4.4. Curation of candidate SR proteins
To assemble our curated inventory of SR proteins, candidates were validated by integrating the
results of all aforementioned analyses. At the domain level, we considered the subfamily
attributed by the alignment procedure as well as the phylogenetic position of the RRM1 domain
in the last trees (Figures S26-29). At the protein level, we applied our determination key (Table
S6) based on the architectural and compositional profiling of candidates (Dataset S3a-d). For
dubious cases, confirmatory searches were conducted on the NCBI BLAST website
(http://blast.ncbi.nlm.nih.gov/). This stepwise validation led to the confirmation of 192 proteins
as genuine SR proteins along with 52 isoforms, of which the overwhelming majority could be
classified into one of the previously identified subfamilies (Table 2; see also Table S7).
16
Table S1. Taxonomic distribution of RRM-containing proteins. The three Excel sheets
summarize the statistics for RRM domain, RRM-containing and putative SR protein content per
proteome for each data source: (i) complete proteomes; (ii) NCBI RefSeq; and (iii) SMART
database. Statistics are given for the five domain E-value thresholds (1e-5, 1e-10, 1e-15, 1e-20
and 1e-25) used in the prediction of RRM domains. Proteomes are sorted by taxonomic lineage,
except that proteomes devoid of RRM domains are listed at the bottom.
Table S2. Hand-curated corpus of RRM-containing proteins collected in the primary
literature. Reference proteins are organized by family. For convenience, an independent
bibliography is provided at the end of the corresponding file.
Table S3. Qualitative comparison of the five large RRM domain trees. The Table is a
companion to Figure S10. Node numbers match those given in tree annotations (Figures S5-9)
and in other comparative display elements (Figures S10-11 and Table S4). Unstable subgroups
are enclosed in brackets. RRM#: RRM number; KOG#: abridged KOG number and name; MP:
1266-cluster parsimony tree; RW: 1266-cluster RAXML (WAG+Γ4) tree; TW: 1266-cluster
TREEFINDER (WAG+Γ4) tree; RL: 1266-cluster RAXML (LG+F+Γ4) tree; mRX: 1831-cluster RAXML
tree; y/n: does/does not exist in the corresponding tree.
Table S4. Summary of the groupings observed for SR protein RRM1 domains. The Table is a
companion to Figure S11. Datasets are described in the text. Node numbers are as in Figure
S10 and Table S3: (16) RRM1 domains of dual RRM SR proteins; (17) RRM1 domains of single
RRM ZnK-like SR proteins; (22-23) RRM1 domains of single RRM SR proteins; (26-27) RRM1
domains of the atypical RNPS1/SR45 proteins.
Table S5. Compositional features specific of one or more SR subfamilies. For each subfamily,
discriminating features used in the SR determination key and secondary features are listed.
Features correspond to single, unordered 2-AA or 3-AA words, respectively. The SRp40-55-75
(SRSF5-6-4) and animal ASF-like (SRSF1-ASF/SF2 and SRSF9/SRp30c) subfamilies were split in
their individual component proteins thus resulting in 16 rows in the Table.
Table S6. Determination key for SR families and subfamilies. The key was constructed by
integrating architectural and compositional features that are specific either of SR natural
families or subfamilies.
17
Table S7. Statistics for the curated inventory of SR proteins in 20 selected proteomes. The
Table is a companion to Table 2 found in the main text. It provides detailed numbers for the
stepwise validation of candidate SR proteins from RRM prediction to phylogenetic analysis and
determination key classification. cand: candidate SR proteins; rej: candidates rejected as non-
SR proteins; iso: isoforms of confirmed SR proteins (mis-modeling or alternative splicing); conf:
candidates confirmed as SR proteins; key: confirmed candidates correctly classified by the
determination key; trunc: truncated candidates (mis-modeling or alternative splicing) that were
incorrectly classified by the determination key. The 7 recently sequenced photosynthetic added
for the inventory are shown in boldface.
18
Figure S1. Scheme of the analysis pipeline. The four sections of the main text results are shown
by discontinuous shaded areas (labeled 1 to 4). Within an area, each colored box corresponds
to a logical analysis step (e.g., program execution followed by processing of its output). For
simplicity, data and execution flows are confounded in the same arrows. Input data sources
and pipeline outputs are symbolized by distinct icons. Both main and Supplemental Figure and
Table numbers are indicated on the corresponding icons. See Text S1 for detailed methods and
technical results.
Figure S2. Optimization of clustering parameters for RRM domains. Non-redundant RRM
domains were clustered by single-linkage based on sequence similarity (fraction of identical
residues). The parameter space for both similarity and coverage thresholds was explored to
determine the combination that maximized a composite score rewarding normalized entropy
but penalizing the number of singleton clusters. The analysis was conducted for each of the five
non-redundant RRM datasets that were obtained at the following domain E-value thresholds:
(A) 1e-5, (B) 1e-10, (C) 1e-15, (D) 1e-20 and (E) 1e-25.
Figure S3. Evaluation of the selection algorithm for cluster representatives. Three clustered
datasets were assembled using either of the following selection criteria for cluster
representatives: (i) longest sequence (orange); (ii) most slowly evolving sequence (green); (iii)
fastest-evolving sequence (red). For each dataset, the corresponding tree was inferred by
Maximum Parsimony along with 100 bootstrap replicates. The resulting tree lengths (in
parsimony steps) are plotted either as a vertical line for the original tree or as a cumulative
distribution for bootstrap replicates.
Figure S4. Color key for KOG annotation. A unique combination of background and text color
has been attributed to each KOG, which are listed by descending occurrence count in the
RRM-containing protein dataset.
Figure S5. Maximum Parsimony tree of representative RRM domains. The tree was obtained
using PAUP* from the analysis of 72 aligned amino acid positions across 1266 sequences and
rooted using prokaryotic RRM domains as outgroups. The length of the tree is 36,439
parsimony steps. Leaves were automatically annotated and colored based on cluster content
using (i) KOG annotation and (ii) reference RRM-containing proteins (Figure S4 and Table S2).
Furthermore, the following information is provided: (iii) the number of domains in the cluster;
(iv) the distribution of RRM numbers in the clusters; (v) the amount of prokaryotic proteins; and
19
(vi) the amount of putative SR proteins. All numbers are given as percentages as well as
logarithmic estimates represented as stretches of stars (*). Clusters that contain domains from
more than one species or at least one prokaryotic RRM are shown in bold and italic,
respectively. Stable groupings are indicated and follow the numbering of Figure S10 and Table
S3. Bootstrap proportions >50% are shown. The scale bar at the bottom gives the number of
substitutions per site.
Figure S6. RAXML tree of representative RRM domains obtained under the WAG+Γ4 model.
The tree was actually obtained under the very similar PROTMIXWAG model from the analysis
of 72 aligned amino acid positions across 1266 sequences and rooted using prokaryotic RRM
domains as outgroups. Leaves were automatically annotated and colored based on cluster
content using (i) KOG annotation and (ii) reference RRM-containing proteins (Figure S4 and
Table S2). Furthermore, the following information is provided: (iii) the number of domains in
the cluster; (iv) the distribution of RRM numbers in the clusters; (v) the amount of prokaryotic
proteins; and (vi) the amount of putative SR proteins. All numbers are given as percentages as
well as logarithmic estimates represented as stretches of stars (*). Clusters that contain domains
from more than one species or at least one prokaryotic RRM are shown in bold and italic,
respectively. Stable groupings are indicated and follow the numbering of Figure S10 and Table
S3. SR-associated subtrees that were further analyzed are shown in pink. Subtrees prok-1 to
prok-3 used to compute prokaryotic RRM logos are also indicated. Bootstrap proportions >50%
are shown. The scale bar at the bottom gives the number of substitutions per site.
Figure S7. TREEFINDER tree of representative RRM domains obtained under the WAG+Γ4
model. The tree was obtained from the analysis of 72 aligned amino acid positions across 1266
sequences and rooted using prokaryotic RRM domains as outgroups. Leaves were automatically
annotated and colored based on cluster content using (i) KOG annotation and (ii) reference
RRM-containing proteins (Figure S4 and Table S2). Furthermore, the following information is
provided: (iii) the number of domains in the cluster; (iv) the distribution of RRM numbers in the
clusters; (v) the amount of prokaryotic proteins; and (vi) the amount of putative SR proteins. All
numbers are given as percentages as well as logarithmic estimates represented as stretches of
stars (*). Clusters that contain domains from more than one species or at least one prokaryotic
RRM are shown in bold and italic, respectively. Stable groupings are indicated and follow the
numbering of Figure S10 and Table S3. Bootstrap proportions >50% are shown. The scale bar
at the bottom gives the number of substitutions per site.
20
Figure S8. RAXML tree of representative RRM domains obtained under the LG+F+Γ4 model.
The tree was obtained from the analysis of 72 aligned amino acid positions across 1266
sequences and rooted using prokaryotic RRM domains as outgroups. Leaves were automatically
annotated and colored based on cluster content using (i) KOG annotation and (ii) reference
RRM-containing proteins (Figure S4 and Table S2). Furthermore, the following information is
provided: (iii) the number of domains in the cluster; (iv) the distribution of RRM numbers in the
clusters; (v) the amount of prokaryotic proteins; and (vi) the amount of putative SR proteins. All
numbers are given as percentages as well as logarithmic estimates represented as stretches of
stars (*). Clusters that contain domains from more than one species or at least one prokaryotic
RRM are shown in bold and italic, respectively. Stable groupings are indicated and follow the
numbering of Figure S10 and Table S3. Bootstrap proportions >50% are shown. The scale bar
at the bottom gives the number of substitutions per site.
Figure S9. RAXML tree of the enlarged RRM dataset obtained under the WAG+Γ4 model. The
tree was actually obtained under the very similar PROTMIXWAG model from the analysis of 72
aligned amino acid positions across 1831 sequences and rooted using prokaryotic RRM
domains as outgroups. Leaves were automatically annotated and colored based on cluster
content using (i) KOG annotation and (ii) reference RRM-containing proteins (Figure S4 and
Table S2). Furthermore, the following information is provided: (iii) the number of domains in
the cluster; (iv) the distribution of RRM numbers in the clusters; (v) the amount of prokaryotic
proteins; and (vi) the amount of putative SR proteins. All numbers are given as percentages as
well as logarithmic estimates represented as stretches of stars (*). Clusters that contain domains
from more than one species or at least one prokaryotic RRM are shown in bold and italic,
respectively. Stable groupings are indicated and follow the numbering of Figure S10 and Table
S3. Bootstrap proportions >50% are shown. The scale bar at the bottom gives the number of
substitutions per site.
Figure S10. Qualitative consensus of phylogenetic analyses of representative RRM domains.
The consensus is based on a manual comparison of the 5 large trees (Figures S5-9). Recurrent
nodes across analyses were uniquely numbered by descending grouping level. Unstable
subgroups are enclosed in brackets. Notes about individual nodes and trees can be found in
companion Table S3. Simple terminal branches correspond to functionally homogenous
groupings, whereas open triangles represent mixed functionality. SR-associated subtrees are
indicated by shaded boxes and the corresponding branches are color-coded to match Figures 2,
3 and S11: RRM1 of single RRM SR proteins (green); RRM1 of single RRM ZnK-like SR proteins
21
(blue); RRM1 of dual RRM SR proteins (red); RRM1 of RNPS1/SR45 proteins (orange); RRM2 of
non-plant dual RRM SR proteins (violet); RRM2 of the plant-specific ‘RS’ group of SR proteins
(brown). Note that node names are based on automated KOG annotation without manual
curation, hence the presence of occasional inaccuracies (e.g., node 83 labelled as 'splicing
factor RNPS1' while it actually includes PABP proteins; see Table S3).
Figure S11. Mutual affinities of SR protein RRM domains in the five large trees. Cartoons (A)
to (E) summarize the trees given in Figures S5 to S9, respectively, and leaf node numbers are
described in Figure S10 and Table S3. Simple terminal branches correspond to functionally
homogenous groupings, whereas open triangles represent mixed functionality. SR-associated
RRM domains are color-coded as in Figures 2, 3 and S10, while outgroup RRM domains are
shown in black. Companion Table S4 summarizes the groupings observed in each tree for the
RRM1 domains of SR splicing factors.
Figure S12. RAXML tree of the largest RRM clusters obtained under the LG+F+Γ4 model. The
tree was obtained from the analysis of 72 aligned amino acid positions across 152 slowly
evolving RRM sequences representative of all multi-species RRM clusters with ≥ 8 member
domains (i.e., 10,101 out of 12,023 retrieved domains), and rooted using prokaryotic RRM
clusters as outgroups (in italic). Leaves were automatically annotated and colored based on
cluster content using (i) KOG annotation and (ii) reference RRM-containing proteins (Figure S4
and Table S2). Furthermore, the following information is provided: (iii) the number of domains
in the cluster; (iv) the distribution of RRM numbers in the clusters; (v) the amount of prokaryotic
proteins; and (vi) the amount of putative SR proteins. All numbers are given as percentages as
well as logarithmic estimates represented as stretches of stars (*). Stable groupings are indicated
and follow the numbering of Figure S10 and Table S3. All non-zero bootstrap proportions are
shown. The scale bar at the bottom gives the number of substitutions per site.
Figure S13. Exhaustive RAXML tree of SR-associated RRM1 domains (WAG+Γ4 model). The
tree was actually obtained under the very similar PROTMIXWAG model from the analysis of 93
aligned amino acid positions across 434 sequences and was left unrooted as 'outgroups' are not
monophyletic. Leaves correspond to unique domain sequences belonging to clusters present in
the 'RRM1 of SR proteins' subtree (in pink in Figure S6). Annotation is as described for Figures
S5-9. Bootstrap proportions >50% are shown. The scale bar at the bottom gives the number of
substitutions per site.
22
Figure S14. Exhaustive TREEFINDER tree of SR-associated RRM1 domains (WAG+Γ4 model).
The unrooted tree was obtained from the analysis of 93 aligned amino acid positions across
434 sequences and was left unrooted as 'outgroups' are not monophyletic. Leaves correspond
to unique domain sequences belonging to clusters present in the 'RRM1 of SR proteins' subtree
(in pink in Figure S6). Annotation is as described for Figures S5-9. Bootstrap proportions >50%
are shown. The scale bar at the bottom gives the number of substitutions per site.
Figure S15. RAXML tree of RRM1 domains from RNPS1-like proteins (WAG+Γ4 model). The
tree was actually obtained under the very similar PROTMIXWAG model from the analysis of 73
aligned amino acid positions across 42 sequences and rooted between RNPS1 and SR45
domains. Leaves correspond to unique domain sequences belonging to clusters present in the
'RRM1 of SR45/RNPS1' subtree (in pink in Figure S6). Annotation is as described for Figures S5-
9. Bootstrap proportions >50% are shown. The scale bar at the bottom gives the number of
substitutions per site.
Figure S16. TREEFINDER tree of RRM1 domains from RNPS1-like proteins (WAG+Γ4 model).
The unrooted tree was obtained from the analysis of 73 aligned amino acid positions across 42
sequences and rooted between RNPS1 and SR45 domains. Leaves correspond to unique
domain sequences belonging to clusters present in the 'RRM1 of SR45/RNPS1' subtree (in pink
in Figure S6). Annotation is as described for Figures S5-9. Bootstrap proportions >50% are
shown. The scale bar at the bottom gives the number of substitutions per site.
Figure S17. RAXML tree of RRM2 domains from dual RRM SR proteins (WAG+Γ4 model). The
tree was actually obtained under the very similar PROTMIXWAG model from the analysis of 97
aligned amino acid positions across 349 sequences and rooted between SR-associated and
outgroup domains. Leaves correspond to unique domain sequences belonging to clusters
present in the 'RRM2 of dual RRM SR proteins' subtree (in pink in Figure S6). Annotation is as
described for Figures S5-9. Bootstrap proportions >50% are shown. The scale bar at the bottom
gives the number of substitutions per site.
Figure S18. TREEFINDER tree of RRM2 domains from dual RRM SR proteins (WAG+Γ4 model).
The unrooted tree was obtained from the analysis of 97 aligned amino acid positions across
349 sequences and rooted between SR-associated and outgroup domains. Leaves correspond to
unique domain sequences belonging to clusters present in the 'RRM2 of dual RRM SR proteins'
23
subtree (in pink in Figure S6). Annotation is as described for Figures S5-9. Bootstrap proportions
>50% are shown. The scale bar at the bottom gives the number of substitutions per site.
Figure S19. RAXML tree of slowly evolving SR-associated RRM1 domains (WAG+Γ4 model).
The tree was actually obtained under the very similar PROTMIXWAG model from the analysis
of 87 aligned amino acid positions across 304 sequences and was left unrooted as 'outgroups'
are not monophyletic. Leaves correspond to unique domain sequences belonging to clusters
present in the 'RRM1 of SR proteins' subtree (in pink in Figure S6), of which 130 fast-evolving
(i.e., long-branched) sequences have been removed. Annotation is as described for Figures S5-
9. Bootstrap proportions >50% are shown. The scale bar at the bottom gives the number of
substitutions per site.
Figure S20. TREEFINDER tree of slowly evolving SR-associated RRM1 domains (WAG+Γ4
model). The tree was obtained from the analysis of 87 aligned amino acid positions across 304
sequences and was left unrooted as 'outgroups' are not monophyletic. Leaves correspond to
unique domain sequences belonging to clusters present in the 'RRM1 of SR proteins' subtree (in
pink in Figure S6), of which 130 fast-evolving (i.e., long-branched) sequences have been
removed. Annotation is as described for Figures S5-9. Bootstrap proportions >50% are shown.
The scale bar at the bottom gives the number of substitutions per site.
Figure S21. Sequence conservation in the first RRM domain of SR proteins. RRM sequence
logos are aligned based on secondary structure (bottom). At a given position, the height of any
residue is proportional to its frequency while overall stack height corresponds to sequence
conservation. Error bars reflects the uncertainty of conservation estimates. Small sample sizes
lead to conservatively downscaled letters (e.g., RS2Z subfamily and SR45). RNP1 and RNP2
motifs are shaded, as are conserved aromatic residues in these motifs. β1-4, α1-2 and L1-5
respectively stand for β-sheets, α-helices and linkers of the RRM secondary structure. The
Figure contains four panels, one for each natural family of SR proteins: (A) single RRM; (B)
single RRM ZnK-like; (C) dual RRM; and (D) RNPS1-like. In (C), RS2Z proteins were grouped
with other ZnK-containing proteins even if their RRM is quite different, including RNP motifs.
Figure S22. Sequence conservation across prokaryotic RRM domains. RRM sequence logos are
aligned based on secondary structure (bottom). At a given position, the height of any residue is
proportional to its frequency while overall stack height corresponds to sequence conservation.
Error bars reflects the uncertainty of conservation estimates. RNP1 and RNP2 motifs are shaded,
24
as are conserved aromatic residues in these motifs. β1-4, α1-2 and L1-5 respectively stand for
β-sheets, α-helices and linkers of the RRM secondary structure. The 2 upper logos respectively
include all prokaryotic or cyanobacterial RRM domains independently of their actual position
in the phylogenetic tree (Figure S6). The 3 lower logos each correspond to one of the mainly
prokaryotic subtrees used as outgroups, of which non-prokaryotic domains were excluded.
Grey boxes highlight motifs specific of the discrete cyanobacterial subtree (middle).
Figure S23. Sequence conservation across ZnK domains of SR proteins. Thanks to their very
constraint size, ZnK sequence logos were easily aligned by hand. At a given position, the height
of any residue is proportional to its frequency while overall stack height corresponds to
sequence conservation. Error bars reflects the uncertainty of conservation estimates. To increase
sampling for RSZ and RS2Z logos, ZnK domains from SR proteins identified in the inventory of
the seven additional photosynthetic proteomes were also included. Left and right ZnK domains
from RS2Z proteins were considered separately in an attempt to determine their respective
ancestry by comparison with SRSF7/9G8 and RSZ homologues (grey boxes). However, this
analysis proved inconclusive due to the short size of ZnKs. Universally conserved CCHC motifs
(yellow) and glycine residues (orange) are also shaded. ZnKs of the CCHC family have amino
acid arrangements with the consensus sequence 'C-ϕ-X-C-G-±-X-G-H-X3-δ-C,' where X is a
variable amino acid, ϕ is an aromatic amino acid, (±) is a charged amino acid, and δ is a
carbonyl-containing residue (Green and Berg, 1989; Cavaloc et al., 1994; Cavaloc et al., 1999;
Armas et al., 2008).
Figure S24. Distributions of relevant compositional features within SR subfamilies. Each panel
corresponds to the distributions of the density of a particular word (1, 2 or 3 unordered
residues) in a specific region across all subfamilies. Regions are bounded by RRM and ZnK
domains and defined as follows: (i) before the first domain; (ii) between the first and the second
domain; and (iii) after the last domain (e.g., RS/SR before RRM1 or GG between RRM1 and
ZnK1). For a given word/region combination, density is computed as the number of
overlapping word occurrences in a sliding-window of 24 amino acid residues scanning the
region in each protein. Maximal word densities (i.e., highest peaks) are then pooled by
subfamily to allow joint plotting of resulting distributions on a single graph. Numbers in panel
legends indicate the number of analyzed proteins in each subfamily. This number can vary
between word/region combinations because of (i) mis-modeled proteins lacking one or more
canonical domains of the family and (ii) non-prediction of divergent domains. Similarly, not all
25
combinations can be analyzed for every subfamily, e.g., single RRM SR proteins do not possess
an interdomain region.
Figure S25. Architecture, conservation and compositional profile of SR subfamilies. Within
each panel, an individual protein was selected as representative for compositional profiling
while conservation was computed on the alignment of all subfamily sequences. The SRp40-55-
75 (SRSF5-6-4) and animal ASF-like (SRSF1-ASF/SF2 and SRSF9/SRp30c) subfamilies were split
in their individual component proteins thus resulting in 16 panels. In these cases, a single
subfamily alignment was used for conservation profiling in respectively three (K, L, M) and two
(H, I) panels. Only informative features (Table S5) are shown, with discriminating features used
in the key (Table S6) in plain style and secondary features in dashed style. (A) SC35: human
SRSF2/SC35 (ENSP00000293233); (B) SCL: Arabidopsis At-SCL33 (NP_001031195); (C) SRrp:
mouse SRSF10/SRrp40 (ENSMUSP00000030437); (D) 9G8: human SRSF7/9G8
(ENSP00000325905); (E) SRp20: human SRSF3/SRp20 (ENSP00000362820); (F) RSZ:
Arabidopsis At-RSZ21 (NP_564208); (G) RS2Z: rice Os-RS2Z36 (NP_001054489); (H)
ASF/SF2: human SRSF1-ASF/SF2 (ENSP00000258962); (I) SRp30c: human SRSF9/SRp30c
(ENSP00000229390); (J) ASF-like: rice Os-SR32 (NP_001050082); (K) SRp40: human
SRSF5/SRp40 (ENSP00000342294); (L) SRp55: human SRSF6/SRp55 (ENSP00000244020); (M)
SRp75: human SRSF4/SRp75 (ENSP00000362900); (N) RS: Arabidopsis At-RS41 (NP_200017);
(O) SR45: Arabidopsis SR45 (NP_173107); (P) RNPS1: human RNPS1 (ENSP00000380275).
Figure S26. RAXML RRM tree of candidate SR proteins from selected proteomes (WAG+Γ4
model). The tree was actually obtained under the very similar PROTMIXWAG model from the
analysis of 64 unambiguously aligned amino acid positions across 270 sequences and
arbitrarily rooted using RNPS1-like proteins. Positions corresponding to subfamily-specific
insertions were discarded from the full alignment (82 amino acid positions) prior to analysis.
RRM2 domains from RS proteins were also included to test the duplication hypothesis (see
main text). Annotation was limited to KOG identifiers and reference RRM-containing proteins,
supplemented with a subfamily code added during automatic alignment on subfamily
consensus (e.g., asflkpl stands for plant ASF-like). Bootstrap proportions >50% are shown. The
scale bar at the bottom gives the number of substitutions per site.
Figure S27. TREEFINDER RRM tree of candidate SR proteins from selected proteomes (WAG+Γ4
model). The tree was obtained from the analysis of 64 unambiguously aligned amino acid
positions across 270 sequences and arbitrarily rooted using RNPS1-like proteins. Positions
26
corresponding to subfamily-specific insertions were discarded from the full alignment (82
amino acid positions) prior to analysis. RRM2 domains from RS proteins were also included to
test the duplication hypothesis. Annotation was limited to KOG identifiers and reference RRM-
containing proteins, supplemented with a subfamily code added during automatic alignment on
subfamily consensus (e.g., asflkpl stands for plant ASF-like). Bootstrap proportions >50% are
shown. The scale bar at the bottom gives the number of substitutions per site.
Figure S28. RAXML tree of candidate SR proteins from selected proteomes (LG+F+Γ4 model).
The tree was obtained from the analysis of 64 unambiguously aligned amino acid positions
across 270 sequences and arbitrarily rooted using RNPS1-like proteins. Positions corresponding
to subfamily-specific insertions were discarded from the full alignment (82 amino acid
positions) prior to analysis. RRM2 domains from RS proteins were also included to test the
duplication hypothesis. Annotation was limited to KOG identifiers and reference RRM-
containing proteins, supplemented with a subfamily code added during automatic alignment on
subfamily consensus (e.g., asflkpl stands for plant ASF-like). Bootstrap proportions >50% are
shown. The scale bar at the bottom gives the number of substitutions per site.
Figure S29. PHYLOBAYES tree of candidate SR proteins from selected proteomes (CAT+Γ4
model). The tree was obtained from the analysis of 64 unambiguously aligned amino acid
positions across 270 sequences. It is the consensus of two independent chains ran for 55,000
cycles (burn-in = 5000 cycles; one tree sampled every 100 cycles) and is arbitrarily rooted
using RNPS1-like proteins. Positions corresponding to subfamily-specific insertions were
discarded from the full alignment (82 amino acid positions) prior to analysis. RRM2 domains
from RS proteins were also included to test the duplication hypothesis. Annotation was limited
to KOG identifiers and reference RRM-containing proteins, supplemented with a subfamily
code added during automatic alignment on subfamily consensus (e.g., asflkpl stands for plant
ASF-like). Posterior probabilities (PP) >50% are shown (whereas nodes with PP <5% are
collapsed). The scale bar at the bottom gives the number of substitutions per site.
27
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29
i
organism name description accession #RRM references
. ARRS — acidic rich RS protein (RRM and RS domains)
Mus musculus Psc1 – AAS19274 1 Kavanagh et al. (2005)
Mus musculus ARRS – BAC34721 1 Kavanagh et al. (2005)
Homo sapiens KIAA1311 – BAA92549 1 Kavanagh et al. (2005)
Homo sapiens Se70-2 – AAH41655 1 Kavanagh et al. (2005)
Xenopus laevis RBM26 – AAH43744 1 Kavanagh et al. (2005)
Drosophila melanogaster ARRS – NP_609976 1 Kavanagh et al. (2005)
Anopheles gambiae ARRS – XP_318628 1 Kavanagh et al. (2005)
Caenorhabditis elegans ARRS – NP_498234 1 Kavanagh et al. (2005)
Dictyostelium discoideum ARRS – AA051188 1 Kavanagh et al. (2005)
Homo sapiens RBM 26 – NP_071401 2 Kavanagh et al. (2005)
Homo sapiens RBM 27 – NP_061862 1 Kavanagh et al. (2005)
. Bruno — CUG-BP1 and ETR-3 like factors (CELF)/BRUNO-like proteins
Homo sapiens CUGBP 1 CUG triplet repeat, RNA-binding protein 1 NP_006551 3 Timchenko et al. (1996)
Homo sapiens CUGBP 2 ETR-3 NP_001020247 3 Lu et al. (1999)
Homo sapiens CELF 3 Bruno-like 3 NP_064565 3 Ladd et al. (2001)
Homo sapiens CELF 4 Bruno-like 4 Q9BZC1 3 Ladd et al. (2001)
Homo sapiens CELF 5 Bruno-like 5 NP_068757 3 Ladd et al. (2001)
Homo sapiens CELF 6 Bruno-like 6 NP_443072 3 Ladd et al. (2004)
Mus musculus CUGBP 1 – NP_059064 3 Timchenko et al. (2006)
Mus musculus BRUNOL-4 – NP_573458 3 Meins et al. (2002)
Mus musculus BRUNOL-6 – NP_780444 3 McKee et al. (2005)
Gallus gallus CUGBP 1 – NP_001012539 3 Brimacombe and Ladd (2007)
Rattus norvegicus CUGBP 1 – NP_001020592 3 Karagiannides et al. (2006)
Danio rerio CUGBP 1 – NP_571688 3 Hashimoto et al. (2006)
Xenopus laevis EDEN-BP embryo deadenylation element binding protein NP_001084196 3 Paillard et al. (1998)
. CAPER — coactivator of activating protein-1 (AP-1) and estrogen receptors (Ers)
Homo sapiens CAPER – NP_909122 3 Jung et al. (2002)
Mus musculus CAPER – NP_573505 3 Jung et al. (2002)
. CPEB — cytoplasmic polyadenylation element binding protein
Homo sapiens CPEB 1 – NP_085097 2 Welk et al. (2001)
Homo sapiens CPEB 2 – NP_872587 2 Hagele et al. (2008)
Homo sapiens CPEB 3 – NP_055727 2 Salehi-Ashtiani et al. (2006)
Homo sapiens CPEB 4 – NP_085130 2 Kurihara et al. (2003)
Table S2
30
ii
organism name description accession #RRM references
Xenopus laevis CPEB – NP_001084072 2 Paris et al. (1991)
Mus musculus CPEB 1 – NP_031781 2 Gebauer and Richter (1996)
Mus musculus CPEB 2 – NP_787951 2 Kurihara et al. (2003)
Mus musculus CPEB 3 – NP_938042 2 Theis et al. (2003)
Mus musculus CPEB 4 – NP_080528 2 Theis et al. (2003)
Rattus norvegicus CPEB 1 – NP_001099746 2 Wu et al. (1998)
. Dazap — Deleted in azoospermia-associated protein
Homo sapiens Dazap1 DAZ associated protein 1 NP_061832 2 Tsui et al. (2000)
Mus musculus Dazap1 DAZ associated protein 1 NP_573451 2 Dai et al. (2001)
Mus musculus Dazap1 DAZ associated protein 1 NP_001116077 2 Dai et al. (2001)
Rattus norvegicus Dazap1 DAZ associated protein 1 NP_001020913 2 Pan et al. (2005)
Xenopus laevis Dazap1 DAZ associated protein 1 and Prrp (proline-rich RNA binding protein) Q98SJ2 2 Zhao et al. (2001)
. ELAV — embryonic lethal, abnormal vision, Drosophila-like 1/Hu
Mus musculus ELAVL 1/HuR Hu antigen R NP_034615 3 Atasoy et al. (1998)
Mus musculus ELAVL 2 Hu antigen B NP_034616 3 Abe et al. (1996b)
Mus musculus ELAVL 3 Hu antigen C NP_034617 3 Okano and Darnell (1997)
Mus musculus ELAVL 4 Hu antigen D NP_034618 3 Abe et al. (1994)
Homo sapiens ELAVL 1/HuR Hu antigen R NP_001410 3 Ma et al. (1996)
Homo sapiens ELAVL 2/HuB Hu antigen B NP_004423 3 Levine et al. (1993)
Homo sapiens ELAVL 3 Hu antigen C NP_001411 3 Van Tine et al. (1998)
Homo sapiens ELAVL 4 Hu antigen D NP_068771 3 Szabo et al. (1991)
Gallus gallus ELAVL 4 Hu antigen D NP_990161 3 Wakamatsu and Weston (1997)
Gallus gallus ELAVL 1/HuR Hu antigen R NP_990164 3 Wakamatsu and Weston (1997)
Rattus norvegicus ELAVL 1/HuR Hu antigen R NP_001102318 3 Tang et al. (2002)
Rattus norvegicus ELAVL 2/HuB Hu antigen B NP_775431 3 Fornaro et al. (2007)
Rattus norvegicus ELAVL 3 Hu antigen C NP_758827 3 Abe et al. (1996a)
Rattus norvegicus ELAVL 4 Hu antigen D NP_001071119 3 Steller et al. (1996)
. FCAFPA — other Arabidopsis RRM proteins FCA and FPA
Arabidopsis thaliana FCA – CAB10407 2 Macknight et al. (1997)
Arabidopsis thaliana FCA-like – AAB63831 2 Lorkovic and Barta (2002)
Arabidopsis thaliana FPA – AAB64314 3 Schomburg et al. (2001)
Arabidopsis thaliana AtY14 – AAG52616 1 Park and Muench (2007)
Arabidopsis thaliana AtREF – NP_200803 1 Lorkovic and Barta (2002)
Arabidopsis thaliana AtREF – AAG51767 1 Lorkovic and Barta (2002)
Arabidopsis thaliana AtREF – CAB85990 1 Lorkovic and Barta (2002)
Table S2
31
iii
organism name description accession #RRM references
Arabidopsis thaliana AtREF – NP_198588 1 Lorkovic and Barta (2002)
. FOX — Feminizing locus on X
Caenorhabditis elegans Fox-1 – NP_508446 1 Hodgkin et al. (1994)
Homo sapiens Fox-1 ataxin 2-binding protein 1 NP_665898 1 Shibata et al. (2000)
Homo sapiens Fox-2 RBM 9 NP_001076045 1 Lieberman et al. (2001)
Homo sapiens Fox-3 hexaribonucleotide binding protein NP_001076044 1 Underwood et al. (2005)
Mus musculus Fox-1 ataxin 2-binding protein NP_067452 1 Kiehl et al. (2001)
Mus musculus Fox-2 RBM 9 NP_444334 1 Lieberman et al. (2001)
Danio rerio Fox-1 ataxin 2-binding protein-like NP_999940 1 Jin et al. (2003)
. G3BP — Ras-GTPase-activating protein SH3-domain-binding protein
Homo sapiens G3BP 1 – NP_938405 1 Parker et al. (1996)
Homo sapiens G3BP 2 – NP_987100 1 Prigent et al. (2000)
Mus musculus G3BP 1 – NP_038744 1 Kennedy et al. (1996)
. GRSRBP — Glycine-Rich-RNA Binding (GR-RBP) and small RNA-binding protein (S-RBP)
Arabidopsis thaliana GR-RBP1 – AAD22311 1 Lorkovic and Barta (2002)
Arabidopsis thaliana GR-RBP2 – CAB36849 1 Lorkovic and Barta (2002)
Arabidopsis thaliana GR-RBP3 – BAB10366 1 Lorkovic and Barta (2002)
Arabidopsis thaliana GR-RBP4 – BAB03001 1 Lorkovic and Barta (2002)
Arabidopsis thaliana GR-RBP5 – AAG52402 1 Lorkovic and Barta (2002)
Arabidopsis thaliana GR-RBP6 – AAF98412 1 Lorkovic and Barta (2002)
Arabidopsis thaliana GR-RBP7 – AAD23639 1 Heintzen et al. (1997)
Arabidopsis thaliana GR-RBP8 – CAB43641 1 Carpenter et al. (1994)
Arabidopsis thaliana AtRZ-1a – BAB02203 1 Lorkovic and Barta (2002)
Arabidopsis thaliana AtRZ-1b – AAB71977 1 Lorkovic and Barta (2002)
Arabidopsis thaliana AtRZ-1c – NP_196048 1 Lorkovic and Barta (2002)
Arabidopsis thaliana AtRZ-1-like – AAG51392 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP1 – CAB78428 1 Lorkovic and Barta (2002)
Zea mays GRP – NP_001105707 1 Didierjean et al. (1992)
Nicotiana sylvestris RZ-1 – BAA06012 1 Hanano et al. (1996)
Homo sapiens GRSF 1 G-rich RNA sequence binding factor 1 NP_002083 3 Qian and Wilusz (1994)
Homo sapiens RBM3 – NP_006734 1 Danno et al. (1997)
Homo sapiens CIRP – NP_001271 1 Nishiyama et al. (1997)
Mus musculus CIRP – NP_031731 1 Nishiyama et al. (1997)
Table S2
32
iv
organism name description accession #RRM references
. IGF2BP — insulin-like growth factor 2 RNA binding protein
Homo sapiens IGF2BP 1 – NP_006537 2 Nielsen et al. (1999)
Homo sapiens IGF2BP 2 – NP_006539 2 Nielsen et al. (1999)
Homo sapiens IGF2BP 3 – NP_006538 2 Nielsen et al. (1999)
. LA — LA
Homo sapiens La – NP_003133 1 Maraia and Intine (2001)
Homo sapiens Larp 7 – NP_056269 1 Krueger et al. (2008)
Mus musculus Ssb Sjogren syndrome antigen B NP_001103615 1 Maraia and Intine (2001)
Mus musculus Larp7 – NP_613059 1 Krueger et al. (2008)
Arabidopsis thaliana La1 – NP_001031777 1 Fleurdepine et al. (2007)
Arabidopsis thaliana La – NP_178106 2 Fleurdepine et al. (2007)
Arabidopsis thaliana La – NP_974184 2 Fleurdepine et al. (2007)
Arabidopsis thaliana La – NP_974185 2 Fleurdepine et al. (2007)
Arabidopsis thaliana La – NP_188540 1 Fleurdepine et al. (2007)
Arabidopsis thaliana La – NP_851141 1 Fleurdepine et al. (2007)
Oryza sativa La – BAD19607 2 Fleurdepine et al. (2007)
Oryza sativa La – CAE03115 2 Fleurdepine et al. (2007)
Schizosaccharomyces pombe la1 – NP_593315 1 Van Horn et al. (1997)
Saccharomyces cerevisiae Lhp1 – NP_010232 1 Yoo and Wolin (1994)
Drosophila melanogaster La – NP_724257 1 Yoo and Wolin (1994)
. LARK — LARK
Homo sapiens RBM4 LARK NP_002887 2 Markus and Morris (2006)
Mus musculus RBM4 LARK NP_033058 2 Kojima et al. (2007)
Drosophila melanogaster LARK – NP_523957 2 McNeil et al. (2001)
Bombyx mori LARK – NP_001037293 2 Wang et al. (2005)
. Musashi — Musashi
Homo sapiens musashi 1 neural-specific RNA binding protein NP_002433 2 Good et al. (1998)
Homo sapiens musashi 2 neural-specific RNA binding protein NP_620412 2 Barbouti et al. (2003)
Mus musculus Musashi 1 neural-specific RNA binding protein homolog 1 NP_032655 2 Sakakibara et al. (1996)
Mus musculus Musashi 2 neural-specific RNA binding protein homolog 2 NP_473384 2 Sakakibara et al. (2001)
Xenopus laevis nrp-1B neural-specific RNA binding protein NP_001084040 2 Richter et al. (1990)
Caenorhabditis elegans Musashi-1 neural-specific RNA binding protein NP_497799 2 Yoda et al. (2000)
Ciona intestinalis Musashi neural-specific RNA binding protein NP_001027721 2 Kawashima et al. (2000)
Halocynthia roretzi Musashi neural-specific RNA binding protein BAA82622 2 Kawashima et al. (2000)
Table S2
33
v
organism name description accession #RRM references
. NTF — RRM proteins containing the NTF domain
Arabidopsis thaliana NTF-RRM1 – AAF20222 2 Lorkovic and Barta (2002)
Arabidopsis thaliana NTF-RRM2 – AAD20086 1 Lorkovic and Barta (2002)
Arabidopsis thaliana NTF-RRM3 – AAF27060 1 Lorkovic and Barta (2002)
Arabidopsis thaliana NTF-RRM4 – AAF81299 1 Lorkovic and Barta (2002)
Arabidopsis thaliana NTF-RRM5 – BAB09056 1 Lorkovic and Barta (2002)
Arabidopsis thaliana NTF-RRM6 – BAB10647 1 Lorkovic and Barta (2002)
Arabidopsis thaliana NTF-RRM7 – BAB10698 1 Lorkovic and Barta (2002)
Arabidopsis thaliana NTF-RRM8 – BAB02073 1 Lorkovic and Barta (2002)
Arabidopsis thaliana NTF-RRM9 – AAF20221 2 Lorkovic and Barta (2002)
. P54nrb — 54 kD nuclear RNA-binding protein/ non-POU domain containing, octamer-binding
Homo sapiens p54nrb – NP_031389 2 Dong et al. (1993)
Mus musculus NonO – NP_075633 2 Yang et al. (1993)
Rattus norvegicus NonO/p54nrb – NP_001020442 2 Too et al. (1998)
Rattus norvegicus NonO – NP_001012356 2 Brown et al. (2005)
Xenopus laevis P54nrb – NP_001080735 2 Takahashi et al. (2005)
Drosophila melanogaster NonA no on or off transient A NP_523367 2 Jones and Rubin (1990)
. PABP — poly(A)-binding proteins
Homo sapiens PABPC1 – NP_002559 4 Hosoda et al. (2006)
Homo sapiens PABP2 – NP_004634 1 Wahle (1991)
Homo sapiens PABPC3 – NP_112241 3 Feral et al. (2001)
Homo sapiens PABPC4 – NP_003810 4 Yang et al. (1995)
Homo sapiens PABPC5 – NP_543022 4 Blanco et al. (2001)
Mus musculus PAPB2 – NP_001007463 1 Cosson et al. (2004)
Mus musculus PABP1 – NP_032800 4 Wang et al. (1992)
Mus musculus PABP2 – NP_035163 4 Kleene et al. (1998)
Mus musculus PABPC5 – NP_444344 4 Blanco et al. (2001)
Rattus norvegicus PABP1 – NP_599180 4 Lim et al. (2006)
Drosophila melanogaster PABPC1 – NP_725750 4 Behm-Ansmant et al. (2007)
Drosophila melanogaster PABPN1 – NP_476902 1 Behm-Ansmant et al. (2007)
Xenopus laevis PABPC1 – NP_001080204 4 Voeltz et al. (2001)
Xenopus laevis ePAB – NP_001082094 4 Voeltz et al. (2001)
Bos taurus PABPN1 – NP_776994 1 Kuhn et al. (2003)
Arabidopsis thaliana PABP1 – NP_174676 3 Belostotsky (2003)
Arabidopsis thaliana PABP2 – NP_195137 2 Belostotsky (2003)
Arabidopsis thaliana PABP3 – NP_173690 4 Belostotsky (2003)
Table S2
34
vi
organism name description accession #RRM references
Arabidopsis thaliana PABP4 – NP_179916 4 Belostotsky (2003)
Arabidopsis thaliana PABP5 – NP_177322 4 Belostotsky (2003)
Arabidopsis thaliana PABP6 – NP_188259 4 Belostotsky (2003)
Arabidopsis thaliana PABP7 – NP_181204 4 Belostotsky (2003)
Arabidopsis thaliana PABP8 – NP_564554 4 Belostotsky (2003)
Arabidopsis thaliana PABP9 – NP_175125 4 Belostotsky (2003)
Arabidopsis thaliana PABN1 – NP_568751 1 Forbes et al. (2006)
Chlamydomonas reinhardtii RB57 – XP_001689671 4 Yohn et al. (1998)
Saccharomyces cerevisiae Pab1p – NP_011092 4 Otero et al. (1999)
Saccharomyces cerevisiae Rbp29 – NP_012266 1 Winstall et al. (2000)
Schizosaccharomyces pombe Pab2 – CAB16904 1 Perreault et al. (2007)
. PDIP — DNA polymerase delta interacting protein 3
Homo sapiens PDIP3 PDIP46 NP_115687 1 Smyk et al. (2006)
Mus musculus PDIP3 – NP_848742 1 Liu et al. (2003)
. PSF — polypyrimidine tract binding protein associated, splicing factor proline/glutamine rich
Homo sapiens PSF sfpq NP_005057 2 Gozani et al. (1994)
Mus musculus PSF sfpq NP_076092 2 Shav-Tal et al. (2001)
Danio rerio PSF sfpq NP_998443 2 Lowery et al. (2007)
. PSP1 — paraspeckle protein
Homo sapiens PSP1 paraspeckle protein 1 NP_001035879 2 Fox et al. (2002)
Mus musculus PSP1 paraspeckle protein 1 NP_079958 2 Myojin et al. (2004)
. PTBP — polypyrimidine tract-binding protein
Homo sapiens PTBP1 – NP_114368 4 Gil et al. (1991)
Homo sapiens PTBP2 – NP_067013 4 Markovtsov et al. (2000)
Mus musculus PTBP1 – NP_032982 4 Bothwell et al. (1991)
Mus musculus PTBP2 brPTB NP_062423 4 Polydorides et al. (2000)
Rattus norvegicus PTBP1 PTB4 NP_071961 4 Gooding et al. (2003)
Rattus norvegicus PTBP smPTB NP_877970 4 Gooding et al. (2003)
Rattus norvegicus PTBP2 nPTB NP_001005555 4 Gooding et al. (2003)
. RALYL — RALY RNA binding protein and RALY-like
Homo sapiens RALYL – NP_776247 1 Ji et al. (2003)
Homo sapiens RALY hnRNP-associated with lethal yellow NP_031393 1 Khrebtukova et al. (1999)
Table S2
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vii
organism name description accession #RRM references
Mus musculus RALY hnRNP-associated with lethal yellow NP_075619 1 Khrebtukova et al. (1999)
. RBM — RNA Binding Motif proteins
Homo sapiens RBM1 RNPC1 NP_906270 1 Shu et al. (2006)
Homo sapiens RBM5 – NP_005769 2 Shu et al. (2007)
Homo sapiens RBM6 – NP_005768 2 Wang et al. (2007b)
Homo sapiens RBM8A – NP_005096 1 Salicioni et al. (2000)
Homo sapiens RBM8B – AAG16782 1 Salicioni et al. (2000)
Homo sapiens RBM10 – NP_690595 2 Inoue et al. (1996)
Rattus norvegicus RBM10 – NP_690600 2 Inoue et al. (1996)
Homo sapiens RBM12 – NP_690051 4 Stover et al. (2001)
Pongo pygmaeus RBM12 – Q5RBM8 4 GenBank
Macaca mulatta RBM12 – Q8SQ27 4 GenBank
Mus musculus RBM12 – Q8R4X3 4 GenBank
Homo sapiens RBM14 – NP_006319 2 Iwasaki et al. (2001)
Homo sapiens RBM15 – NP_073605 3 Ma et al. (2001)
Mus musculus RBM15 – NP_001039272 3 Ma et al. (2007)
Homo sapiens RBM22 – NP_060517 1 Montaville et al. (2006)
Homo sapiens RBM25 – NP_067062 1 Fortes et al. (2007)
Homo sapiens RBM28 – NP_060547 4 Damianov et al. (2006)
Homo sapiens RBM40 – Q96LT9 2 Zhao et al. (2003)
Mus musculus RBM40 – Q3UZ01 2 Zhao et al. (2003)
Rattus norvegicus RBM40 – Q4G055 2 GenBank
Homo sapiens RBM45 – NP_694453 4 Tamada et al. (2002)
Mus musculus RBM45 – NP_700454 4 Tamada et al. (2002)
. RBMS — RNA binding motif, single stranded interacting protein
Homo sapiens RBMS1 scr2/MSSP1 NP_002888 2 Kanaoka and Nojima (1994) ; Negishi et al. (1994)
Homo sapiens RBMS2 scr3 NP_002889 2 Kanaoka and Nojima (1994)
Homo sapiens RBMS3 – NP_001003792 2 Penkov et al. (2000) ; Fritz and Stefanovic (2007)
Mus musculus RBMS1 – NP_064692 2 Fujimoto et al. (2000)
Mus musculus RBMS2 – NP_062685 2 Fujimoto et al. (2000)
Gallus gallus RBMS1 – NP_990355 2 Kimura et al. (1998)
. RBMY — RNA binding motif protein, Y-linked, family 1
Homo sapiens RBMY A1 – NP_005049 1 Chai et al. (1998)
Homo sapiens RBMY B – NP_001006121 1 Chai et al. (1998)
Homo sapiens RBMY D – NP_001006120 1 Chai et al. (1998)
Table S2
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organism name description accession #RRM references
Homo sapiens RBMY E – NP_001006118 1 Chai et al. (1998)
Homo sapiens RBMY F – NP_689798 1 Chai et al. (1998)
Homo sapiens RBMY J – NP_001006117 1 Chai et al. (1998)
. RDM1 — RAD52 motif 1
Homo sapiens RDM1 – NP_663629 1 Hamimes et al. (2005)
Gallus gallus RDM1 – NP_989877 1 Hamimes et al. (2005)
Mus musculus RDM1 – NP_079930 1 Hamimes et al. (2005)
. RNPS1 — RNA-binding protein S1
Homo sapiens RNPS1 – NP_006702 1 Badolato et al. (1995)
Mus musculus RNPS1 – NP_033096 1 Schmidt and Werner (1993)
. SART3 — squamous cell carcinoma antigen recognized by T cells 3
Homo sapiens SART 3 – NP_055521 2 Harada et al. (2001)
Mus musculus SART 3 – NP_058622 2 Harada et al. (2000)
Danio rerio SART 3 – NP_001025289 2 Trede et al. (2007)
Rattus norvegicus SART 3 – NP_001100626 2 GenBank
. SR — SR proteins
Homo sapiens SRp20 – P84103 1 Zahler et al. (1992)
Homo sapiens SC35 – NP_003007 1 Fu and Maniatis (1992)
Homo sapiens SRp30c – AAA93069 2 Screaton et al. (1995)
Homo sapiens 9G8 – NP_001026854 1 Cavaloc et al. (1994)
Homo sapiens ASF/SF2 – NP_008855 2 Krainer et al. (1990) ; Ge and Manley (1990)
Homo sapiens SRp40 – NP_008856 2 Screaton et al. (1995)
Homo sapiens SRp46 – NP_115285 1 Soret et al. (1998)
Homo sapiens SRp55 – Q13247 2 Screaton et al. (1995)
Homo sapiens SRp54 – NP_004759 1 Zhang and Wu (1996)
Homo sapiens SRp75 – Q08170 2 Zahler et al. (1993)
Arabidopsis thaliana SRp30 – NP_172386 2 Lopato et al. (1999b)
Arabidopsis thaliana SR1/SRp34 – O22315 2 Lazar et al. (1995)
Arabidopsis thaliana SRp34a – NP_190512 2 Lorkovic and Barta (2002)
Arabidopsis thaliana SRp34b – NP_567235 2 Lorkovic and Barta (2002)
Arabidopsis thaliana RSp31 – P92964 2 Lopato et al. (1996)
Arabidopsis thaliana RSp31a – NP_182184 2 Kalyna and Barta (2004)
Arabidopsis thaliana RSp40/SRp35 – P92965 2 Lopato et al. (1996)
Table S2
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ix
organism name description accession #RRM references
Arabidopsis thaliana RSp41 – P92966 2 Lopato et al. (1996)
Arabidopsis thaliana SRZ21/RSZ21 – AAD12770 1 Golovkin and Reddy (1998)
Arabidopsis thaliana SRZ22/RSZ22 – NP_194886 1 Golovkin and Reddy (1998)
Arabidopsis thaliana RSZ22a – NP_180035 1 Lopato et al. (1999a)
Arabidopsis thaliana RSZ32 – NP_190918 1 Lopato et al. (2002)
Arabidopsis thaliana RSZ33 – CAC03605 1 Lopato et al. (2002)
Arabidopsis thaliana SC35 – NP_201225 1 Lopato et al. (2002)
Arabidopsis thaliana SR33/SCL33 – NP_564685 1 Golovkin and Reddy (1999)
Arabidopsis thaliana SCL30 – NP_567021 1 Lopato et al. (2002)
Arabidopsis thaliana SCL30a – NP_187966 1 Lopato et al. (2002)
Arabidopsis thaliana SCL28 – NP_197382 1 Lopato et al. (2002)
Arabidopsis thaliana SR45 – Q9SEE9 1 Golovkin and Reddy (1999)
Oryza sativa SRp32 – AK061903 2 Isshiki et al. (2006)
Oryza sativa SRp33a – AK106176 2 Isshiki et al. (2006)
Oryza sativa SRp33b – AK071503 2 Isshiki et al. (2006)
Oryza sativa SR20 – AK103534 2 Isshiki et al. (2006)
Oryza sativa SC35a – AK103676 1 Isshiki et al. (2006)
Oryza sativa SC35b – AK070292 1 Isshiki et al. (2006)
Oryza sativa SC35c – AK073057 1 Isshiki et al. (2006)
Oryza sativa SCL25 – AK073451 1 Isshiki et al. (2006)
Oryza sativa SCL30a – AK062577 1 Isshiki et al. (2006)
Oryza sativa SCL30b – AK065531 1 Isshiki et al. (2006)
Oryza sativa RSZp21a – AK063879 1 Isshiki et al. (2006)
Oryza sativa RSZp21b – AK073210 1 Isshiki et al. (2006)
Oryza sativa RSZp23 – AK060088 1 Isshiki et al. (2006)
Oryza sativa RSp29 – AK102071 2 Isshiki et al. (2006)
Oryza sativa RSp33 – AK121372 2 Isshiki et al. (2006)
Oryza sativa RSZ36 – AK103897 1 Isshiki et al. (2006)
Oryza sativa RSZ37a – AK060171 1 Isshiki et al. (2006)
Oryza sativa RSZ37b – AK073348 1 Isshiki et al. (2006)
Oryza sativa RSZ39 – AK063518 1 Isshiki et al. (2006)
Zea mays SRp30 – AAU29331 2 Gao et al. (2004)
Zea mays SRp30’ – Q64HB9 2 Gao et al. (2004)
Zea mays SRp31 – Q64HB5 2 Gao et al. (2004)
Zea mays SRp31" – Q64HB8 2 Gao et al. (2004)
Zea mays SRp32 – AAU29328 2 Gao et al. (2004)
Zea mays SRp32’ – Q64HC2 2 Gao et al. (2004)
Caenorhabditis elegans CeSRp75/rsp-1 – Q23121 2 Longman et al. (2000)
Table S2
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x
organism name description accession #RRM references
Caenorhabditis elegans CeSRp40/rsp-2 – Q23120 2 Longman et al. (2000)
Caenorhabditis elegans CeSF2/ASF/rsp-3 – Q9NEW6 2 Longman et al. (2000)
Caenorhabditis elegans CeSC35/rsp-4 – Q09511 1 Longman et al. (2000)
Caenorhabditis elegans CeSC35-2/rsp-5 – Q10021 1 Longman et al. (2000)
Caenorhabditis elegans CeSRp20/rsp-6 – Q18409 1 Longman et al. (2000)
Caenorhabditis elegans Cep54/rsp-7 – O01159 2 Longman et al. (2000)
Drosophila melanogaster SC35 – NP_652612 1 Allemand et al. (2001)
Drosophila melanogaster 9G8 – AAF43414 1 Allemand et al. (2001)
Drosophila melanogaster SRp55 – CAA41556 2 Roth et al. (1991)
Schizosaccharomyces pombe Srp1 – AAC49909 1 Gross et al. (1998)
Chironomus tentans Hrp45 – Z54163 2 Alzhanova-Ericsson et al. (1996)
. SRrp — SR related protein
Homo sapiens SRp40 – AAL57514 1 Cowper et al. (2001)
Homo sapiens SRrp35 – Q8WXF0 1 Cowper et al. (2001)
Homo sapiens SRrp86 – NP_001070667 2 Barnard and Patton (2000)
Homo sapiens SRp38 – NP_473357 1 Shin et al. (2004)
. TARDBP — TAR DNA binding protein
Homo sapiens TARDBP – NP_031401 2 Ou et al. (1995)
Mus musculus TARDBP – NP_663531 2 Buratti and Baralle (2008)
. TIATIAR — T-cell internal antigen-1 (TIA-1) and TIA-1-related protein (TIAR)
Homo sapiens TIAR – NP_003243 3 Kawakami et al. (1992)
Homo sapiens TIA-1 – NP_071320 3 Tian et al. (1991)
Mus musculus TIA-1 – NP_035715 3 Lowin et al. (1996)
Gallus gallus TIA-1 – NP_989687 3 Le Guiner et al. (2003)
Bombyx mori TIA-1 – NP_001036895 3 Kotani et al. (2003)
Rattus norvegicus TIA-1 – NP_001012096 3 GenBank
Mus musculus TiaL1 – NP_033409 3 Beck et al. (1996)
Rattus norvegicus TiaL1 – NP_001013211 3 GenBank
. TIF3 — Translation initiation factor 3
Arabidopsis thaliana TIF3 – AAG51445 1 Lorkovic and Barta (2002)
Arabidopsis thaliana TIF3 – BAB10805 1 Lorkovic and Barta (2002)
Table S2
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xi
organism name description accession #RRM references
. UMH — Proteins with the UHM domain (RRM variant)
Homo sapiens KIS kinase interacting stathmin NP_787062 1 Bieche et al. (2003)
Mus musculus KIS kinase interacting stathmin NP_034763 1 Maucuer et al. (1995)
Rattus norvegicus KIS kinase interacting stathmin NP_058989 1 Maucuer et al. (1997)
Homo sapiens PUF60 poly-U binding splicing factor 60KDa NP_510965 3 Page-McCaw et al. (1999)
Drosophila melanogaster PUF60 poly-U binding splicing factor 60KDa NP_525123 2 Van Buskirk and Schupbach (2002)
Mus musculus PUF60 poly-U binding splicing factor 60KDa AAH10601 2 Kielkopf et al. (2004)
Danio rerio PUF60 poly-U binding splicing factor 60KDa CAD61099 2 Kielkopf et al. (2004)
Anopheles gambiae PUF60 poly-U binding splicing factor 60KDa EAA09944 2 Kielkopf et al. (2004)
Caenorhabditis elegans PUF60 poly-U binding splicing factor 60KDa AAF60676 2 Kielkopf et al. (2004)
Homo sapiens SPF45 RBM17 NP_116294 1 Sampath et al. (2003)
Mus musculus SPF45 RBM17 NP_690037 1 Kielkopf et al. (2004)
Danio rerio SPF45 – AAH45473 1 Kielkopf et al. (2004)
Anopheles gambiae SPF45 – EAA15153 1 Kielkopf et al. (2004)
Drosophila melanogaster SPF45 – EAA46008 1 Chaouki and Salz (2006)
Caenorhabditis elegans SPF45 – CAA97799 1 Kielkopf et al. (2004)
Homo sapiens Tat-SF1 – AAB18823 1 Zhou and Sharp (1996)
Mus musculus Tat-SF1 – AAH37711 1 Kielkopf et al. (2004)
Danio rerio Tat-SF1 – AAH55565 1 Kielkopf et al. (2004)
Drosophila melanogaster Tat-SF1 – AAF51719 1 Kielkopf et al. (2004)
Anopheles gambiae Tat-SF1 – EAA10753 1 Kielkopf et al. (2004)
Caenorhabditis elegans Tat-SF1 – AAK29956 1 Kielkopf et al. (2004)
Homo sapiens HCC1 Hepatocellular carcinoma protein 1 Q14498 2 Imai et al. (1993)
Mus musculus HCC1 – Q8VH51 2 Kielkopf et al. (2004)
Danio rerio HCC1 – AAH44487 2 Kielkopf et al. (2004)
Drosophila melanogaster HCC1 – AAF52478 2 Kielkopf et al. (2004)
Anopheles gambiae HCC1 – EAA12873 2 Kielkopf et al. (2004)
Caenorhabditis elegans HCC1 – AAM97977 2 Kielkopf et al. (2004)
Arabidopsis thaliana HCC1 – AAM20703 2 Kielkopf et al. (2004)
. ZCRB1 — zinc finger CCHC-type and RNA binding motif
Homo sapiens ZCRB1 – NP_149105 1 Wang et al. (2007a)
Mus musculus ZCRB1 – NP_080301 1 Wang et al. (2007a)
. cpRNP — chloroplast RRM containing proteins
Arabidopsis thaliana cpRNP28 – AAD14476 2 Lorkovic and Barta (2002)
Arabidopsis thaliana cpRNP28b – AAF26472 2 Lorkovic and Barta (2002)
Arabidopsis thaliana cpRNP29 – CAB67653 2 Ohta et al. (1995)
Table S2
40
xii
organism name description accession #RRM references
Arabidopsis thaliana cpRNP29b – AAC98043 2 Lorkovic and Barta (2002)
Arabidopsis thaliana cpRNP31 – CAA22986 2 Ohta et al. (1995)
Arabidopsis thaliana cpRNP31b – BAB09396 2 Lorkovic and Barta (2002)
Arabidopsis thaliana cpRNP33 – CAB43448 2 Ohta et al. (1995)
Arabidopsis thaliana cpRNP33b – AAC36180 2 Lorkovic and Barta (2002)
. cyclophilin — cyclophilins
Arabidopsis thaliana AtCyp59 – NP_175776 1 Gullerova et al. (2006)
Rattus norvegicus CypE – NP_001041333 1 GenBank
Caenorhabditis elegans cyp-13 – NP_503034 1 Zorio and Blumenthal (1999)
Mus musculus Cyp-33 – Q9QZH3 1 Anderson et al. (2002)
Drosophila melanogaster Cyp-33 – Q9V3G3 1 Anderson et al. (2002)
Homo sapiens Cyp-33 – Q9UNP9 1 Mi et al. (1996)
Homo sapiens PPIL4 – Q8WUA2 1 Zeng et al. (2001)
Mus musculus PPIL4 – Q9CXG3 1 Zeng et al. (2001)
Schizosaccharomyces pombe PPIL4 – Q9UUE4 1 Pemberton and Kay (2005)
Haemonchus contortus CYP – AAW82658 1 Valle et al. (2005)
. eIF4B — eukaryotic translation initiation factor 4B
Homo sapiens eIF-4B – NP_001408 1 Milburn et al. (1990)
Mus musculus eIF-4B – NP_663600 1 Shahbazian et al. (2006)
. hnRNP — Heterogeneous nuclear ribonucleoprotein
Arabidopsis thaliana AtRNP A/B1 – CAB10209 2 Lorkovic et al. (2000b)
Arabidopsis thaliana AtRNP A/B2 – AAB80680 2 Lorkovic et al. (2000b)
Arabidopsis thaliana AtRNP A/B3 – BAB08572 2 Lorkovic et al. (2000b)
Arabidopsis thaliana AtRNP A/B4 – CAB43861 2 Lorkovic et al. (2000b)
Arabidopsis thaliana AtRNP A/B5 – BAB09088 2 Lorkovic et al. (2000b)
Arabidopsis thaliana AtRNP A/B6 – AAF21191 2 Lorkovic et al. (2000b)
Arabidopsis thaliana AtRNP H/F1 – BAB10406 2 Lorkovic et al. (2000b)
Arabidopsis thaliana AtRNP H/F2 – BAB02497 2 Lorkovic et al. (2000b)
Arabidopsis thaliana AtRNP I/PTB – BAB08421 2 Lorkovic et al. (2000b)
Arabidopsis thaliana AtRNP I/PTB – AAF26159 2 Lorkovic and Barta (2002)
Arabidopsis thaliana AtRNP I/PTB – NP_175010 4 Lorkovic and Barta (2002)
Homo sapiens hnRNP A2/B1 – NP_112533 2 Burd et al. (1989)
Homo sapiens hnRNP A1/A1 – NP_002127 2 Buvoli et al. (1988)
Homo sapiens hnRNP A/B – NP_112556 2 Khan et al. (1991)
Homo sapiens hnRNP A0 – NP_006796 2 Myer and Steitz (1995)
Table S2
41
xiii
organism name description accession #RRM references
Homo sapiens hnRNP C1/C2 – AAH07052 1 Swanson et al. (1987)
Homo sapiens hnRNP C – NP_001070910 1 Swanson et al. (1987)
Homo sapiens hnRNP D – NP_112737 2 Park et al. (2007)
Homo sapiens hnRNP F – NP_001091676 3 Matunis et al. (1994)
Homo sapiens hnRNP G – P38159 1 Soulard et al. (1993)
Homo sapiens hnRNP H3 – NP_036339 2 Mahe et al. (1997)
Homo sapiens hnRNP L – NP_001524 4 Pinol-Roma et al. (1989)
Homo sapiens hnRNP L-like – NP_612403 3 Shur et al. (2004)
Homo sapiens hnRNP R – NP_005817 3 Hassfeld et al. (1998)
Rattus norvegicus hnRNP A2/B1 – NP_001098083 2 Kamma et al. (1999)
Rattus norvegicus hnRNP M – NP_001103381 3 Kafasla et al. (2000)
Chironomus tentans Hrp59 protein – CAH05070 3 Kiesler et al. (2005)
Mus musculus HNRP A/B – NP_034578 2 Inoue et al. (2001)
Mus musculus HNRP L – NP_796275 3 Costain and Mishra (2003)
Mus musculus HNRP M – NP_084080 3 Mahe et al. (2000)
Drosophila melanogaster Hrp36 – CAA44502 2 Matunis et al. (1992)
. nucleolin — nucleolins
Arabidopsis thaliana nucleolin AtNUC-L1 NP_175322 2 Pontvianne et al. (2007)
Arabidopsis thaliana nucleolin AtNUC-L2 NP_188491 2 Pontvianne et al. (2007)
Homo sapiens nucleolin/C23 – NP_005372 4 Srivastava et al. (1989)
Rattus norvegicus nucleolin/C23 – NP_036881 4 Bourbon et al. (1988b)
Schizosaccharomyces pombe GAR2 – NP_593531 2 Gulli et al. (1995)
Saccharomyces cerevisiae NSR1 – NP_011675 2 Edwards et al. (2000)
Xenopus laevis NCL – P20397 4 Heine et al. (1993)
Mus musculus NCL – NP_035010 4 Bourbon et al. (1988a)
. oligoU — oligouridylated-specific RRM proteins (UBP1, RBP45, RBP47, UBA1 et UBA2)
Arabidopsis thaliana RBP45b – NP_172630 3 Lorkovic et al. (2000a)
Arabidopsis thaliana RBP47a – AAG13046 3 Lorkovic et al. (2000a)
Arabidopsis thaliana RBP47b – BAB02953 3 Lorkovic et al. (2000a)
Arabidopsis thaliana RBP47c – AAD46038 3 Lorkovic et al. (2000a)
Arabidopsis thaliana RBP47c’ – AAD46037 3 Lorkovic et al. (2000a)
Nicotiana plumbaginifolia RBP45 – CAC01237 3 Lorkovic et al. (2000a)
Arabidopsis thaliana UBP1a – AAD25780 3 Lambermon et al. (2000)
Arabidopsis thaliana UBP1b – AAF79492 3 Lambermon et al. (2000)
Arabidopsis thaliana UBP1c – BAB02974 3 Lambermon et al. (2000)
Nicotiana plumbaginifolia UBP1 – CAB75429 3 Lambermon et al. (2000)
Table S2
42
xiv
organism name description accession #RRM references
Arabidopsis thaliana UBA2a – NP_850711 2 Lorkovic and Barta (2002)
Arabidopsis thaliana UBA2b – NP_001078035 2 Lorkovic and Barta (2002)
Arabidopsis thaliana UBA2c – BAA97064 2 Lorkovic and Barta (2002)
Arabidopsis thaliana UBA1a – AAD25815 1 Lorkovic and Barta (2002)
Arabidopsis thaliana UBA1b – AAD25814 1 Lorkovic and Barta (2002)
Arabidopsis thaliana UBA1c – AAC16468 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP2 – BAB09544 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP3 – AAC61284 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP4 – CAB88326 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP5 – CAB78306 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP7 – AAG51218 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP8 – AAD20390 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP9 – AAC23648 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP10 – AAF21210 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP11 – BAB09686 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP12 – BAB09337 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP13 – BAB08354 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP14 – AAB88654 1 Lorkovic and Barta (2002)
Arabidopsis thaliana S-RBP15 – BAB09540 1 Lorkovic and Barta (2002)
. snRNP — small nuclear ribonucleoprotein (snRNP)
Solanum tuberosum U1A – CAA90282 2 Simpson et al. (1995)
Homo sapiens U1A – NP_004587 2 Sillekens et al. (1987)
Mus musculus U1A – NP_056597 2 Bennett et al. (1993)
Xenopus laevis U1A – CAA41021 2 Scherly et al. (1991)
Solanum tuberosum U2B” – AAA33847 2 Simpson et al. (1991)
Arabidopsis thaliana U1A – NP_182280 2 Simpson et al. (1995)
Arabidopsis thaliana U170K – CAB62436 1 Golovkin and Reddy (1996)
Arabidopsis thaliana U2B – NP_180585 2 Simpson et al. (1995)
Arabidopsis thaliana U2B – AAF82223 2 Simpson et al. (1991)
Arabidopsis thaliana U2AF65a – CAB80335 2 Domon et al. (1998)
Arabidopsis thaliana U2AF65b – AAG51641 3 Domon et al. (1998)
Arabidopsis thaliana U2SF3b53a – AAD12222 2 Lorkovic and Barta (2002)
Arabidopsis thaliana U2SF3b53b – AAD15475 2 Lorkovic and Barta (2002)
Arabidopsis thaliana U11-35kD – AAB64330 1 Lorkovic and Barta (2002)
Arabidopsis thaliana U2AF35 – BAB10638 1 Domon et al. (1998)
Nicotiana plumbaginifolia U2AF65 – CAA77136 3 Domon et al. (1998)
Zea mays U170K – AAT64945 1 Gupta et al. (2006)
Table S2
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organism name description accession #RRM references
Danio rerio U170K – Q6DRE8 1 Amsterdam et al. (2004)
Mus musculus U11/U1235K – Q9D384 1 GenBank
Homo sapiens U2AF35 – NP_006749 1 Zhang et al. (1992)
Mus musculus U2AF35 – Q9D883 1 Pacheco et al. (2004)
Danio rerio U2AF35 – AAM34646 1 Pacheco et al. (2004)
Drosophila melanogaster U2AF35 – AAB17271 1 Rudner et al. (1996)
Caenorhabditis elegans U2AF35 – CAB55137 1 Zorio and Blumenthal (1999)
Gallus gallus U2AF35 – NP_989986 1 Pacheco et al. (2004)
Schizosaccharomyces pombe U2AF23 – AAC49805 1 Wentz-Hunter and Potashkin (1996)
Homo sapiens U2AF65 – NP_009210 3 Zamore et al. (1992)
Mus musculus U2AF65 – NP_598432 3 Sailer et al. (1992)
Danio rerio U2AF65 – AAH65869 3 Kielkopf et al. (2004)
Caenorhabditis elegans U2AF65 – AAC26982 3 Zorio et al. (1997)
Homo sapiens U11/U12 35K – NP_073208 1 Will et al. (2004)
Mus musculus U2AF1-rs 1 – NP_035793 1 Kitagawa et al. (1995)
Homo sapiens U2A1L3 – Q8WU68 1 Shepard et al. (2002)
Homo sapiens U2AF1L4 – NP_001035515 1 Shepard et al. (2002)
. 30kRRM — 30K-RRM proteins
Arabidopsis thaliana 30K-RRM1 – CAB77597 1 Lorkovic and Barta (2002)
Arabidopsis thaliana 30K-RRM2 – AAF27001 1 Lorkovic and Barta (2002)
Arabidopsis thaliana 30K-RRM3 – AAD30604 1 Lorkovic and Barta (2002)
Arabidopsis thaliana 30K-RRM4 – AAG51948 1 Lorkovic and Barta (2002)
Arabidopsis thaliana 30K-RRM5 – AAF87259 1 Lorkovic and Barta (2002)
Arabidopsis thaliana 30K-RRM6 – AAF71806 1 Lorkovic and Barta (2002)
Arabidopsis thaliana 30K-RRM7 – AAC33496 1 Lorkovic and Barta (2002)
Arabidopsis thaliana 30K-RRM8 – AAK32921 1 Lorkovic and Barta (2002)
Table S2
44
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L. Wu, D. Wells, J. Tay, D. Mendis, M. A. Abbott, A. Bar-nitt, E. Quinlan, A. Heynen, J. R. Fallon, and J. D.Richter. CPEB-mediated cytoplasmic polyadenylationand the regulation of experience-dependent translationof alpha-CaMKII mRNA at synapses. Neuron, 21:1129–39, 1998.
H. Yang, C. S. Duckett, and T. Lindsten. iPABP, an in-ducible poly(A)-binding protein detected in activated hu-man T cells. Mol Cell Biol, 15:6770–6, 1995.
Y. S. Yang, J. H. Hanke, L. Carayannopoulos, C. M.Craft, J. D. Capra, and P. W. Tucker. NonO, a non-POU-domain-containing, octamer-binding protein, isthe mammalian homolog of Drosophila nonAdiss. MolCell Biol, 13:5593–603, 1993.
A. Yoda, H. Sawa, and H. Okano. MSI-1, a neural RNA-binding protein, is involved in male mating behaviour inCaenorhabditis elegans. Genes Cells, 5:885–895, 2000.
C. B. Yohn, A. Cohen, C. Rosch, M. R. Kuchka, and S. P.Mayfield. Translation of the chloroplast psbA mRNArequires the nuclear-encoded poly(A)-binding protein,RB47. J Cell Biol, 142:435–42, 1998.
C. J. Yoo and S. L. Wolin. La proteins from Drosophilamelanogaster and Saccharomyces cerevisiae: a yeast ho-molog of the La autoantigen is dispensable for growth.Mol Cell Biol, 14:5412–24, 1994.
A. M. Zahler, W. S. Lane, J. A. Stolk, and M. B. Roth.SR proteins: a conserved family of pre-mRNA splicingfactors. Genes Dev, 6:837–47, 1992.
A. M. Zahler, K. M. Neugebauer, J. A. Stolk, and M. B.Roth. Human SR proteins and isolation of a cDNA en-coding SRp75. Mol Cell Biol, 13:4023–8, 1993.
P. D. Zamore, J. G. Patton, and M. R. Green. Cloningand domain structure of the mammalian splicing factorU2AF. Nature, 355:609–14, 1992.
L. Zeng, Z. Zhou, J. Xu, W. Zhao, W. Wang, Y. Huang,C. Cheng, M. Xu, Y. Xie, and Y. Mao. Molecular cloning,structure and expression of a novel nuclear RNA-bindingcyclophilin-like gene (PPIL4) from human fetal brain. Cy-togenet Cell Genet, 95:43–7, 2001.
M. Zhang, P. D. Zamore, M. Carmo-Fonseca, A. I. Lam-ond, and M. R. Green. Cloning and intracellular local-ization of the U2 small nuclear ribonucleoprotein auxil-iary factor small subunit. Proc Natl Acad Sci U S A, 89:8769–73, 1992.
Table S2
54
REFERENCES xxvi
W. J. Zhang and J. Y. Wu. Functional properties of p54,a novel SR protein active in constitutive and alternativesplicing. Mol Cell Biol, 16:5400–8, 1996.
E. Zhao, J. Li, Y. Xie, W. Jin, Z. Zhang, J. Chen, L. Zeng,G. Yin, J. Qian, H. Wu, K. Ying, R. C. Zhao, and Y. Mao.Cloning and identification of a novel human RNPC3gene that encodes a protein with two RRM domains andis expressed in the cell nucleus. Biochem Genet, 41:315–23, 2003.
W. M. Zhao, C. Jiang, T. T. Kroll, and P. W. Huber. Aproline-rich protein binds to the localization element ofXenopus Vg1 mRNA and to ligands involved in actinpolymerization. Embo J, 20:2315–25, 2001.
Q. Zhou and P. A. Sharp. Tat-SF1: cofactor for stimula-tion of transcriptional elongation by HIV-1 Tat. Science,274:605–10, 1996.
D. A. Zorio and T. Blumenthal. U2AF35 is encoded
by an essential gene clustered in an operon withRRM/cyclophilin in Caenorhabditis elegans. Rna, 5:487–94, 1999.
D. A. Zorio, K. Lea, and T. Blumenthal. Cloning ofCaenorhabditis U2AF65: an alternatively spliced RNAcontaining a novel exon. Mol Cell Biol, 17:946–53,1997.
Table S2
55
i
node RRM# (KOG#) KOG name reference sequences MP RW TW RL mRW
1 RRM1 (0110) RBP – y y y y1 y
2 RRM1 (0117) hnRNPr hnRNP (excl. flowering plants) y2 y y y y1
3 RRM1 (0123) PABP PABP y3 y y1 y y
4RRM2 (0123) PABP
RRM2 (0131) splicing factor 2b
[RRM2 (0115) RBP p54 nrb]
PABP
– (fungi)
p54 nrb/PSP1/PSF
y4 y5 y4 y4 y5
5 RRM3 (0123) PABP PABP (minor subgroup) y3 y y y y
6 RRM4 (0123) PABP PABP y3 y y y y
7 RRM1 (0144) BRUNOBRUNO
FCAFPA (land plants)y2 y y y y
8 RRM2 (0144) BRUNOBRUNO
FCAFPA (land plants)y2 y y y y
9 RRM3 (0144) BRUNO BRUNO y3 y y y y
10 RRM1 (0145) ELAV/HU ELAV y3 y y y y
11 RRM2 (0145) ELAV/HU ELAV/RBMS y3 y y y y
12 RRM3 (0145) ELAV/HU ELAV y3 y y y y
13 [RRM1 (0151) predicted splicing regulator] – y3 y y1 y1 y1
14 [RRM1 (0153) RBP] RBM y3 y y1 y1 y1
15 – – n6 y y n6 y
16RRM1 (0105) ASF/SF2RRM1 (0106) SRp55/B52/SRp75
dual RRM SR proteins y y y y y
17 [RRM1 (0107) SRp20/9G8] single RRM Zn-K SR proteins y y y y y
18 – see footnote [7] n y n y y
19 [RRM1 (0111) cyclophilin-type PPCTI8] cyclophilin y9 y y9 y9 y
20 [RRM1 (0130) RBP RBM810] RBM y9 y y9 y y
21 – – n n n n y
22 RRM1 (4207) predicted SR protein single RRM SR proteins y y y y y
23 RRM1 (0111) cyclophilin-type PPCTI8 SRrp y y y y y
24 [RRM1 (0121) CBP20] – y y y y y9
25 – – y y y y n11
26 RRM1 (-) SR45 (green plants) y y y y y
27 RRM1 (4209) splicing factor RNPS1 RNPS1 y y y y y
28 – – y y y y y
29RRM2 (0105) ASF/SF2RRM2 (0106) SRp55/B52/SRp75
dual RRM SR proteins (excl. plants) y y y y y
30RRM1/2/3 (4212) hnRNPm
[RRM1 (0533) RRM-containing protein]
hnRNP
PDIP/FCAFPAy12 y13 y13 y12 y12
31 RRM1 (0117) hnRNPr – (flowering plants) y y y y y
32 RRM3 (0110) RBP – y14 y y y y
33 [RRM1 (0115) RBP p54 nrb] p54 nrb-PSP1-PSF n y n n y
34 RRM1 (2277) CID1 – y y y15 y15 y
35RRM1 (0116) Rasputin
RRM1 (0149) SEB4
RRM1/2 (4205) HRP1
G3BP
RBM/30KRRM
hnRNP/Musashi/Dazap/TARDBP/OligoU
y16 y n y16 y
36 RRM1 (0113) U1 snRNP snRNP y15 y y y y
37 RRM2 (0128) SART3 SART3 y15 y y y17 y17
38 [RRM1 (0415) PPCTI8] cyclophilin y15 y15 y y y
39 – – n6 n18 y19 y20 y20
40 RRM1 (4206) U1A/U2B snRNP snRNP y y y y y
41 RRM2 (4206) U1A/U2B snRNP snRNP y y y y y
42 RRM1 (4660) Mei2 – y y y y y
43 RRM2 (4660) Mei2 – y y y y y
44 [RRM1 (0114) RBP] – y y y y y
45 – – n21 n22 n23 n24 n24
46 RRM1 (0131) splicing factor 2b see footnote [25] y y y y y
47 RRM1 (4454) RBP – y y y y y
48 [RRM1 (2193) IGF2BP] IGF2BP y y y y y
Table S3
56
ii
node RRM# (KOG#) KOG name reference sequences MP RW TW RL mRW
49 – – y y n26 y n26
50 RRM1 (0109) LARK LARK y y y y y
51 RRM2 (0109) LARK LARK y y y y y
52 – – n y y n y
53 RRM2 (0112) RBP RBM y y y y y27
54 RRM3 (0112) RBP – y y y y y27
55 – – n y y y y
56 RRM2 (0106) SRp55/B52/SRp75 plant-specific RS group of SR proteins y y y y y
57 RRM1 (0108) RNA15 ZCRB1 y y y y y
58 RRM1 (0108) RNA15 GRSRBP/hnRNP/RBMY y y y y y
59 RRM4/5 (0110) RBP – y y y y y
60 RRM4/5/6 (0110) RBP – y y y y y
61 RRM4 (0112) RBP – y y y y y
62 RRM1 (0117) hnRNPr – (land plants) y y y y y
63 RRM3 (0117) hnRNPr hnRNP n28 y y n28 n28
64 RRM2 (0120) U2AF snRNP y y y y y
65 RRM1 (0122) TIF3 (eIF3) – y y y y y
66 RRM3 (0123) PABP PABP (major subgroup) y29 y y y2930 y30
67RRM2 (0124) PUF60
RRM2 (0147) CAPER/UMH
[RRM1 (0124) PUF60]
UMH
UMH
UMH
y31 y31 y32 y32 y32
68RRM1 (0125) ataxin-2 binding protein
RRM1 (0127) fibrillarin
RRM1 (4661) SAF-B
FOX
– (land plants)
–
n y y y y
69 RRM1 (0126) RBP – y y y y y
70 RRM1 (0127) fibrillarin RBM y y y y y
71 RRM2 (0127) fibrillarin RBM y y y y y
72 RRM3 (0127) fibrillarin RBM y y y y y
73 RRM1 (0128) SART3 SART3 (excl. green plants) y y y y y
74 RRM1 (0128) SART3 – (green plants) y y y y y
75 RRM1 (0147) CAPER/UMH CAPER/UMH y y y y y
76 RRM1 (0148) TIA1/TIAR TIATIAR/OligoU y n6 y y y
77RRM2 (0148) TIA1/TIAR
RRM1 (0226) RBP
TIATIAR/OligoU
–y y y y y
78 RRM3 (0148) TIA1/TIAR OligoU y y y y y
79 RRM3 (0148) TIA1/TIAR TIATIAR/OligoU n6 y y y y
80RRM? (1365) fusillin
RRM2 (4211) hnRNPf
–
hnRNPy y y y y
81 RRM1 (1855) predicted RBP La y y y y y
82 RRM1 (4208) NIFK – y y y y y
83 RRM1 (4209) splicing factor RNPS1 PABP (26%) y y y y y
84 RRM1 (4213) RBP La La y y y y y
85 RRM2 (4676) splicing factor SR rich SRrp y y y y y
86 RRM1 (–) hnRNP/RALYL y y y y y
87 RRM1 (–) eIF4b y y y y y
88 RRM1 (0108)33 prokaryotic RRMs n6 y y y y
1not associated to node (15); 2also associated in MP tree but independently of node (15); 3forming a mini node in MP tree (15); 4RRM2 of
p54 nrb not associated to the group; 5RRM2 of p54 nrb associated to the group; 6split; 79G8 and SC35/SCL groups associated in TF and MP
trees; 8PPCTI: peptidyl-propyl cis-trans isomerase; 9not associated to SR proteins; 10always associated to 9G8 SR proteins; 11RRM1 of CBP20
not associated to the group; 12RRM1 of KOG0533 not associated to the group; 13RRM1 of KOG0533 associated to the group; 14fungal RBP
missing from the group; 15not associated to the group; 16RRM1 of Rasputin not associated to the group; 17more distantly related to the group;18nodes (36, 37) associated; 19nodes (36, 37, 38) associated; 20nodes (36, 37) + (38) associated; 214 groups: nodes (42, 44), node (40), node
(41), and node (43); 222 groups: nodes (41, 42, 43, 44) and node (40); 232 groups: nodes (40, 41, 43, 44) and node (42); 244 groups: nodes (40,
43), node (41), node (42), and node (44); 25snRNPs represent 8% of group proteins; 26RRM1 of IGF2BP not associated to the group; 27nodes
(53) and (54) merged; 28split into plant and animal groups; 29associated to node (5); 30associated to node (6); 31RRM1 of PUF60 not associated
to the group; 32RRM1 of PUF60 associated to the group; 33mostly KOG0108, but also a lower % of KOG0116 and KOG0145
Table S3
57
dataset seq#/AA# meth. heuristic model tree node associations
original 1266x72 MP PAUP* – Fig. S5 [16] vs. [17+(22-23)+(26-27)]
original 1266x72 ML RAxML WAG+G4 Fig. S6 [16+17+(22-23)] vs. [(26-27)]
original 1266x72 ML TreeFinder WAG+G4 Fig. S7 [16] vs. [17+(22-23)] vs. [(26-27)]
original 1266x72 ML RAxML LG+F+G4 Fig. S8 [16+17+(26-27)] vs. [(22-23)]
enlarged 1831x72 ML RAxML WAG+G4 Fig. S9 [16+17+(26-27)] vs. [(22-23)]
Table S4
58
SR subfamily key features secondary features
SC35 K P S KS R RS
SCL P R GR RS E G S
SRrp K P R S KS RS
9G8 R RS S
SRp20 G P R S RS
RSZ G GG GR P R S RS
RS2Z G P R S GR RS
ASF/SF2 G P R S RS
SRp30c G P R S RS
ASF-like (plants) G KS RS SS R S
SRp40 G K S KS R RS
SRp55 G K S KS R RS
SRp75 G K S KS R RS
RS E P R S RS
SR45 K P R S PP RS SS SSS
RNPS1 P R S PP RS SS ST SSS
Table S5
59
step criteria result
1 one RRM domain step 2
two RRM domains step 9
2 2 Zn knuckles . RS2Z1 Zn knuckle step 3
no Zn knuckle step 4
3 enriched in G, GG, GR, GGG between RRM and ZnK . RSZenriched in R, RS between RRM and ZnK . 9G8
4 enriched in P, R, RS before RRM step 5
otherwise step 7
5 enriched in GR before RRM . SCLenriched in S, GS, SS before RRM and P, PP, PPP after RRM step 6
6 enriched in R, ST, SSS before RRM . RNPS1enriched in K, SSS after RRM . SR45
7 enriched in K, KS after RRM and P, S before RRM step 8
enriched G before RRM . SRp208 enriched in R before RRM . SRrp
otherwise . SC359 second RRM lacks SWKDLKD motif . RS
enriched in G between RRMs step 10
10 enriched in KS after second RRM step 11
enriched in G before first RRM . ASF/SF2, SRp30c11 enriched in RS, SS before RRM . ASF-like (plant)
enriched in S, K, KS after last domain . SRp40-55-75
Table S6
60
organism lineage cand rej iso conf key trunc
Homo sapiens Eutheria 23 0 11 12 11 0
Mus musculus Eutheria 26 1 13 12 12 0
Drosophila melanogaster Insecta 15 0 6 9 5 0
Caenorhabditis elegans Nematoda 14 0 7 7 4 0
Aspergillus fumigatus Ascomycota 0 0 0 0 0 0
Arabidopsis thaliana eudicotyledons 29 0 10 19 18 0
Populus trichocarpa eudicotyledons 30 0 0 30 21 6
Oryza sativa Liliopsida 23 1 0 22 17 0
Sorghum bicolor Liliopsida 21 0 0 21 15 4
Selaginella moellendorfii Lycopodiophyta 15 0 5 10 4 4
Physcomitrella patens Bryophyta 12 0 0 12 11 0
Chlamydomonas reinhardtii Chlorophyta 9 0 0 9 4 3
Volvox carteri Chlorophyta 8 1 0 7 1 1
Chlorella sp. NC64A Chlorophyta 7 0 0 7 3 1
Micromonas pusilla CCMP1545 Chlorophyta 3 0 0 3 0 3
Micromonas pusilla RCC299 Chlorophyta 3 0 0 3 1 1
Ostreococcus sp. RCC809 Chlorophyta 3 0 0 3 0 3
Ostreococcus lucimarinus Chlorophyta 3 0 0 3 0 3
Ostreococcus tauri Chlorophyta 1 0 0 1 0 1
Cyanidioschyzon merolae Rhodophyta 2 0 0 2 1 0
Total 247 3 52 192 128 30
Table S7
61
CDD/KOGNCBI Taxonomy
refs fromliterature
CDD/Pfam~700 completeproteomes fromEnsembl, NCBI, JGI...
me
S2
SMART
NCBI RefSeq
CDD/Pfam 20 selected (7 new)complete proteomes
S13
S15
CDD/KOGNCBI Taxonomy
refs fromliterature
S2
Tab. 2S7, DS2
DS3b-d
DS3a
S26-29
Fig. 5
S25S1
S5-9
S13-20
S19
S15S17, S6
S23
Fig. 4
S21
S2-3
S5-6
S24Fig. 1
S22
Fig. 2
S10-12
Tab. 1S3-4
Fig. 3S4
S21
S21
curatedstructuralalignments
exhaustiveHMM profile
alignments
Build HMM profile for
RRM domain
PredictRRM domains using profile
Extractpredicted
RRM domains
Extractpredicted
RRM proteins
Predict putative
SR proteins
Analyzetaxonomic distribution
ClusterRRM domainsby similarity
HMM alignRRM domains using profile
Infer trees of RRM domains
Annotate RRM trees
PruneSR-associated
subtrees
Develop evolutionary
scenario
Draw RRM logos for
SR families
ExtractSR-associatedRRM domains
Prune subtrees forSR families
Extract RRMdomains of SR families
Profile composition of SR families
Extract proteins ofSR families
Build HMM profile for
ZnK domain
PredictZnK domains using profile
Extract ZnKdomains of SR families
Align ZnK domains
Draw ZnK logos for
SR families
Structurally align RRM domains
Profile conservation of SR families
Build RRM profiles for SR proteins
PredictRRM domainsusing profiles
Extract predicted
RRM domains
Extract predicted
RRM proteins
BLAST align RRM domains
using logos
AnalyzeRRM protein architecture
Analyze RRM protein composition
Infer trees of RRM domains
Assemble inventory of SR proteins
Annotate RRM trees
Developkey for SR families
Analyzeprotein
composition
Compare RRM trees
1
2
34
DS1
Fig. S1
62
A. E-value threshold = 1E-05 / # RRM domains = 8471
0
0.5
1
Identity0
0.5
1
Coverage
0
0.5
1
Score
0.75
0.80
0.85
0.90
0.95
1.00
Fig. S2
63
B. E-value threshold = 1E-10 / # RRM domains = 6633
0
0.5
1
Identity0
0.5
1
Coverage
0
0.5
1
Score
0.75
0.80
0.85
0.90
0.95
1.00
Fig. S2
64
C. E-value threshold = 1E-15 / # RRM domains = 4523
0
0.5
1
Identity0
0.5
1
Coverage
0
0.5
1
Score
0.75
0.80
0.85
0.90
0.95
1.00
Fig. S2
65
D. E-value threshold = 1E-20 / # RRM domains = 2311
0
0.5
1
Identity0
0.5
1
Coverage
0
0.5
1
Score
0.75
0.80
0.85
0.90
0.95
1.00
Fig. S2
66
E. E-value threshold = 1E-25 / # RRM domains = 597
0
0.5
1
Identity0
0.5
1
Coverage
0
0.5
1
Score
0.75
0.80
0.85
0.90
0.95
1.00
Fig. S2
67
0
10
20
30
40
50
60
70
80
90
100
30,000 32,000 34,000 36,000 38,000 40,000
Tre
e ra
nk
Tree length (parsimony steps)
slowest sequencefastest sequencelongest sequence
Fig. S3
68
[KOG3208] 1 [Intracellular trafficking, secretion, and vesicular transport] SNARE protein GS28
[KOG4198] 1 [General function prediction only] RNA-binding Ran Zn-finger protein and related proteins
[KOG2490] 1 [Function unknown] Predicted membrane protein
[KOG1611] 1 [General function prediction only] Predicted short chain-type dehydrogenase
[KOG0307] 1 [Intracellular trafficking, secretion, and vesicular transport] Vesicle coat complex COPII, subunit SEC31
[KOG1337] 1 [General function prediction only] N-methyltransferase
[KOG0161] 1 [Cytoskeleton] Myosin class II heavy chain
[KOG1267] 1 [Transcription, General function prediction only] Mitochondrial transcription termination factor, mTERF
[KOG2553] 1 [Translation, ribosomal structure and biogenesis] Pseudouridylate synthase
[KOG0474] 1 [Inorganic ion transport and metabolism] Cl- channel CLC-7 and related proteins (CLC superfamily)
[KOG4246] 1 [General function prediction only] Predicted DNA-binding protein, contains SAP domain
[KOG0197] 1 [Signal transduction mechanisms] Tyrosine kinases
[KOG0475] 1 [Inorganic ion transport and metabolism] Cl- channel CLC-3 and related proteins (CLC superfamily)
[KOG1311] 1 [General function prediction only] DHHC-type Zn-finger proteins
[KOG0591] 1 [Cell cycle control, cell division, chromosome partitioning] NIMA (never in mitosis)-related G2-specific serine/threonine protein kinase
[KOG0687] 1 [Posttranslational modification, protein turnover, chaperones] 26S proteasome regulatory complex, subunit RPN7/PSMD6
[KOG0585] 1 [Signal transduction mechanisms] Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases
[KOG0433] 1 [Translation, ribosomal structure and biogenesis] Isoleucyl-tRNA synthetase
[KOG1924] 1 [Signal transduction mechanisms, Cytoskeleton] RhoA GTPase effector DIA/Diaphanous
[KOG0462] 1 [Translation, ribosomal structure and biogenesis] Elongation factor-type GTP-binding protein
[KOG4177] 1 [Cell wall/membrane/envelope biogenesis] Ankyrin
[KOG2029] 1 [Function unknown] Uncharacterized conserved protein
[KOG0941] 1 [Posttranslational modification, protein turnover, chaperones] E3 ubiquitin protein ligase
[KOG0899] 1 [Translation, ribosomal structure and biogenesis] Mitochondrial/chloroplast ribosomal protein S19
[KOG2186] 1 [Cell cycle control, cell division, chromosome partitioning] Cell growth-regulating nucleolar protein
[KOG1860] 1 [Intracellular trafficking, secretion, and vesicular transport, Cell cycle control, cell division, chromosome partitioning] Nuclear protein export factor
[KOG2476] 1 [Function unknown] Uncharacterized conserved protein
[KOG2087] 1 [Signal transduction mechanisms] Glycoprotein hormone receptor
[KOG1178] 2 [Secondary metabolites biosynthesis, transport and catabolism] Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes
[KOG1832] 2 [Cell cycle control, cell division, chromosome partitioning] HIV-1 Vpr-binding protein
[KOG1274] 2 [General function prediction only] WD40 repeat protein
[KOG1457] 2 [General function prediction only] RNA binding protein (contains RRM repeats)
[KOG3766] 2 [Transcription] Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans)
[KOG0331] 2 [RNA processing and modification] ATP-dependent RNA helicase
[KOG3070] 2 [Translation, ribosomal structure and biogenesis] Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing
[KOG4307] 2 [General function prediction only] RNA binding protein RBM12/SWAN
[KOG3001] 2 [Chromatin structure and dynamics, Transcription] Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins
[KOG2141] 2 [Signal transduction mechanisms] Protein involved in high osmolarity signaling pathway
[KOG1833] 2 [Nuclear structure, Intracellular trafficking, secretion, and vesicular transport] Nuclear pore complex, gp210 component
[KOG3257] 2 [Translation, ribosomal structure and biogenesis] Mitochondrial/chloroplast ribosomal protein L11
[KOG0055] 3 [Secondary metabolites biosynthesis, transport and catabolism] Multidrug/pheromone exporter, ABC superfamily
[KOG1144] 3 [Translation, ribosomal structure and biogenesis] Translation initiation factor 5B (eIF-5B)
[KOG4849] 3 [RNA processing and modification] mRNA cleavage factor I subunit/CPSF subunit
[KOG2248] 3 [Replication, recombination and repair] 3'-5' exonuclease
[KOG1984] 3 [Intracellular trafficking, secretion, and vesicular transport] Vesicle coat complex COPII, subunit SFB3
[KOG4574] 4 [General function prediction only] RNA-binding protein (contains RRM and Pumilio-like repeats)
[KOG0598] 4 [General function prediction only, Signal transduction mechanisms] Ribosomal protein S6 kinase and related proteins
[KOG1365] 4 [RNA processing and modification, General function prediction only] RNA-binding protein Fusilli, contains RRM domain
[KOG0576] 4 [Signal transduction mechanisms] Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family
[KOG2044] 4 [Replication, recombination and repair, RNA processing and modification] 5'-3' exonuclease HKE1/RAT1
[KOG1548] 4 [Transcription] Transcription elongation factor TAT-SF1
[KOG3702] 5 [RNA processing and modification] Nuclear polyadenylated RNA binding protein
[KOG1240] 5 [Signal transduction mechanisms] Protein kinase containing WD40 repeats
[KOG2277] 6 [Cell cycle control, cell division, chromosome partitioning] S-M checkpoint control protein CID1 and related nucleotidyltransferases
[KOG1080] 6 [Chromatin structure and dynamics, Transcription] Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases
[KOG0119] 6 [RNA processing and modification] Splicing factor 1/branch point binding protein (RRM superfamily)
[KOG1015] 6 [Transcription] Transcription regulator XNP/ATRX, DEAD-box superfamily
[KOG0670] 7 [RNA processing and modification] U4/U6-associated splicing factor PRP4
[KOG2193] 8 [RNA processing and modification, General function prediction only] IGF-II mRNA-binding protein IMP, contains RRM and KH domains
[KOG0154] 8 [General function prediction only] RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains
[KOG2253] 8 [RNA processing and modification] U1 snRNP complex, subunit SNU71 and related PWI-motif proteins
[KOG0548] 9 [Posttranslational modification, protein turnover, chaperones] Molecular co-chaperone STI1
[KOG4210] 13 [Transcription] Nuclear localization sequence binding protein
[KOG4368] 19 [General function prediction only] Predicted RNA binding protein, contains SWAP, RPR and G-patch domains
[KOG1190] 19 [RNA processing and modification] Polypyrimidine tract-binding protein
[KOG4213] 19 [RNA processing and modification] RNA-binding protein La
[KOG3598] 21 [Transcription] Thyroid hormone receptor-associated protein complex, subunit TRAP230
[KOG0132] 22 [RNA processing and modification, Transcription] RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains
[KOG1855] 34 [General function prediction only] Predicted RNA-binding protein
[KOG4454] 34 [General function prediction only] RNA binding protein (RRM superfamily)
[KOG4660] 34 [Cell cycle control, cell division, chromosome partitioning] Protein Mei2, essential for commitment to meiosis, and related proteins
[KOG4676] 39 [RNA processing and modification] Splicing factor, arginine/serine-rich
[KOG0153] 42 [General function prediction only] Predicted RNA-binding protein (RRM superfamily)
[KOG0921] 44 [Transcription] Dosage compensation complex, subunit MLE
[KOG0151] 53 [General function prediction only] Predicted splicing regulator, contains RRM, SWAP and RPR domains
[KOG0130] 56 [General function prediction only] RNA-binding protein RBM8/Tsunagi (RRM superfamily)
[KOG0114] 56 [General function prediction only] Predicted RNA-binding protein (RRM superfamily)
[KOG4207] 58 [RNA processing and modification] Predicted splicing factor, SR protein superfamily
[KOG1995] 66 [General function prediction only] Conserved Zn-finger protein
[KOG0121] 74 [RNA processing and modification] Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)
[KOG0226] 76 [General function prediction only] RNA-binding proteins
[KOG0415] 77 [Posttranslational modification, protein turnover, chaperones] Predicted peptidyl prolyl cis-trans isomerase
[KOG4208] 77 [General function prediction only] Nucleolar RNA-binding protein NIFK
[KOG0120] 86 [RNA processing and modification] Splicing factor U2AF, large subunit (RRM superfamily)
[KOG0126] 88 [General function prediction only] Predicted RNA-binding protein (RRM superfamily)
[KOG4661] 93 [Transcription] Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)
[KOG0533] 94 [RNA processing and modification] RRM motif-containing protein
[KOG0112] 97 [General function prediction only] Large RNA-binding protein (RRM superfamily)
[KOG0122] 102 [Translation, ribosomal structure and biogenesis] Translation initiation factor 3, subunit g (eIF-3g)
[KOG0128] 106 [RNA processing and modification] RNA-binding protein SART3 (RRM superfamily)
[KOG4206] 107 [RNA processing and modification] Spliceosomal protein snRNP-U1A/U2B
[KOG0107] 113 [RNA processing and modification] Alternative splicing factor SRp20/9G8 (RRM superfamily)
[KOG0113] 123 [RNA processing and modification] U1 small nuclear ribonucleoprotein (RRM superfamily)
[KOG4211] 135 [RNA processing and modification] Splicing factor hnRNP-F and related RNA-binding proteins
[KOG0111] 140 [Posttranslational modification, protein turnover, chaperones] Cyclophilin-type peptidyl-prolyl cis-trans isomerase
[KOG0124] 144 [RNA processing and modification] Polypyrimidine tract-binding protein PUF60 (RRM superfamily)
[KOG4209] 145 [RNA processing and modification] Splicing factor RNPS1, SR protein superfamily
[KOG0116] 149 [Signal transduction mechanisms] RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains
[KOG0106] 164 [RNA processing and modification] Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)
[KOG0125] 167 [General function prediction only] Ataxin 2-binding protein (RRM superfamily)
[KOG0149] 178 [General function prediction only] Predicted RNA-binding protein SEB4 (RRM superfamily)
[KOG0109] 199 [RNA processing and modification, General function prediction only] RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains
[KOG0147] 203 [Transcription] Transcriptional coactivator CAPER (RRM superfamily)
[KOG0131] 205 [RNA processing and modification] Splicing factor 3b, subunit 4
[KOG0115] 209 [RNA processing and modification] RNA-binding protein p54nrb (RRM superfamily)
[KOG0110] 233 [General function prediction only] RNA-binding protein (RRM superfamily)
[KOG0127] 246 [RNA processing and modification] Nucleolar protein fibrillarin NOP77 (RRM superfamily)
[KOG0105] 292 [RNA processing and modification] Alternative splicing factor ASF/SF2 (RRM superfamily)
[KOG0146] 297 [RNA processing and modification] RNA-binding protein ETR-3 (RRM superfamily)
[KOG4212] 328 [RNA processing and modification] RNA-binding protein hnRNP-M
[KOG0108] 359 [RNA processing and modification] mRNA cleavage and polyadenylation factor I complex, subunit RNA15
[KOG0144] 435 [RNA processing and modification] RNA-binding protein CUGBP1/BRUNO (RRM superfamily)
[KOG0117] 515 [RNA processing and modification] Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)
[KOG0148] 534 [RNA processing and modification, Translation, ribosomal structure and biogenesis] Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily)
[KOG0145] 972 [RNA processing and modification] RNA-binding protein ELAV/HU (RRM superfamily)
[KOG0123] 1303 [RNA processing and modification, Translation, ribosomal structure and biogenesis] Polyadenylate-binding protein (RRM superfamily)
[KOG4205] 1554 [RNA processing and modification] RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1
identifier count process description
Fig. S4
69
61
60
59
66
54
57
50
75
62
70
75
81
Plasmodium falciparum 3D7@XP 001352039[RRM1][KOG0144]Cryptosporidium parvum_Iowa_II@XP_628599[RRM1][KOG4205]Viridiplantae@29631_m001006[3][RRM1:100%*][put-sr:33%][KOG0108:67%][.KOG2253:33%]Euteleostomi@ENSGACP00000016390[7][RRM1:100%*][put-sr:86%*][RBM:14%][KOG2253:100%*]
Thalassiosira pseudonana@jgi_Thaps3_20887[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_44468[RRM1]
Coelomata@XP_001182806[39][RRM1:100%***][KOG0108:13%*][.KOG0116:8%*][.KOG0921:5%]Sordariomycetes@XP_956776[2][RRM1:100%][put-sr:50%]
Trypanosomatidae@XP_827554[2][RRM1:50%][.RRM2:50%][put-sr:50%]Ashbya gossypii_ATCC_10895@NP_983970[RRM1]
Yarrowia lipolytica@XP_504609[RRM1]Pichia stipitis_CBS_6054@XP_001384729[RRM1]
Dictyostelium discoideum_AX4@XP_643642[RRM2][KOG0148]Thalassiosira pseudonana@jgi_Thaps3_24369[RRM1]
Phytophthora@jgi_Phyra1_1_76845[2][RRM1:100%][KOG0123:100%]Phaeodactylum tricornutum@jgi_Phatr2_44442[RRM1][KOG4211]
Ciona@ENSCSAVP00000001842[2][RRM1:100%]Euteleostomi@ENSSARP00000000775[28][RRM1:100%***][eIF4B:54%**]
Drosophila melanogaster@CG10837-PA[3][RRM1:100%*]Anopheles gambiae@AGAP000525-PA[RRM1]
Coelomata@ENSDARP00000093407[32][RRM2:88%***][.RRM1:12%*][KOG0108:12%*][.KOG3001:6%][.KOG0123:6%][.KOG0126:6%]Phaeodactylum tricornutum@jgi_Phatr2_46145[RRM2]
Apis mellifera@XP_394565[RRM2][KOG0147]Ascomycota@XP_505055[6][RRM1:83%*][.RRM2:17%]
Dictyostelium discoideum_AX4@XP_635997[RRM2]Caenorhabditis elegans@F11A10_7[RRM2][KOG0131]
Magnoliophyta@30054_m000807[2][RRM2:100%][KOG1267:50%]Ostreococcus@jgi_Ostta4_30189[2][RRM1:50%][.RRM2:50%][put-sr:50%]
Volvox carteri@jgi_Volca1_118759[RRM2]Dictyostelium discoideum_AX4@XP_642758[RRM1]
Aureococcus anophagefferens@jgi_Auran1_17171[RRM1][KOG0108]Phytophthora@jgi_Phyra1_1_83430[2][RRM1:100%]
Ostreococcus@jgi_Ost9901_3_31221[2][RRM1:100%][KOG0128:100%]Magnoliophyta@29609_m000574[4][RRM1:100%*][KOG0128:100%*]
Physcomitrella patens@jgi_Phypa1_1_135986[RRM1][KOG0128]Schizosaccharomyces pombe_972h-@NP_595728[RRM1]
Ustilago maydis_521@XP_762237[RRM1]Aspergillus fumigatus_Af293@XP_755976[RRM1]
Apocrita@XP_001602363[2][RRM1:100%][KOG1832:50%]Schizosaccharomyces pombe_972h-@NP_596033[RRM1]Phytophthora@jgi_Physo1_1_136292[2][RRM1:100%]
Phaeodactylum tricornutum@jgi_Phatr2_32836[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_570477[RRM1]Sordariomycetes@XP_389032[2][RRM1:100%]
Neurospora crassa_OR74A@XP_964518[RRM1]Takifugu rubripes@SINFRUP00000134535[RRM1][KOG0123]
Kluyveromyces lactis@XP_451368[RRM3][KOG0123]Ashbya gossypii_ATCC_10895@NP_984845[RRM3][KOG0123]
Saccharomyces cerevisiae@YFR023W[RRM3][KOG0123]Saccharomyces cerevisiae@YHR015W[RRM3][KOG0123]
Candida glabrata_CBS138@XP_447635[RRM3][KOG0123]Arabidopsis thaliana@NP_175125[7][RRM1:43%*][.RRM2:29%][.RRM4:14%][.RRM3:14%][PABP:29%][KOG0123:100%*]
Dictyostelium discoideum_AX4@XP_646584[RRM1][KOG0127]Chlamydomonadales@jgi_Chlre3_186870[2][RRM1:100%][KOG0127:100%]
Magnoliophyta@NP_565513[6][RRM1:100%*][KOG0127:100%*]Physcomitrella patens@jgi_Phypa1_1_201182[RRM1][KOG0127]
Tetraodontidae@GSTENP00014994001[2][RRM1:50%][.RRM3:50%][KOG0123:50%]Euteleostomi@GSTENP00022906001[41][RRM3:83%***][.RRM2:10%*][.RRM1:7%*][nucleolin:54%***][KOG0123:93%***]
Euteleostomi@ENSMODP00000021210[32][RRM2:97%***][nucleolin:59%**][KOG0123:100%***]Ciona@ENSCINP00000008105[4][RRM1:100%*][KOG0116:50%][.KOG2141:25%]Dictyostelium discoideum_AX4@XP_638463[RRM1][KOG0110]
Caenorhabditis elegans@T23F6_4_1[2][RRM1:100%][KOG0110:100%]Euteleostomi@GSTENP00029551001[21][RRM1:100%***][put-sr:10%][KOG0110:100%***]
Saccharomycetaceae@XP_001386803[2][RRM1:100%][KOG0110:100%]Ustilago maydis_521@XP_758493[RRM1][KOG0110]
Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM1][KOG0110]Viridiplantae@jgi_Phypa1_1_207810[3][RRM1:100%*][KOG0110:100%*]
Arabidopsis thaliana@NP_196191[RRM1][KOG0110]Drosophila melanogaster@CG3335-PA[RRM1][KOG0110]Apocrita@XP_624611[2][RRM1:100%][KOG0110:100%]
Culicidae@AGAP005249-PA[2][RRM1:100%][KOG0110:100%]Schizosaccharomyces pombe_972h-@NP_595599[RRM1][KOG0110]
Deuterostomia@ENSMODP00000011218[78][RRM1:100%****][G3BP:82%****][KOG0116:100%****]Ciona@ENSCINP00000009845[4][RRM1:100%*][KOG0116:100%*]
Tribolium castaneum@XP_975463[RRM1][KOG0116]Apis mellifera@XP_623996[RRM1][KOG0116]
Leptospira@YP_001385[4][RRM1:100%*][PROK:100%*]Coelomata@ENSXETP00000008271[74][RRM1:100%****][LARK:61%***][KOG0109:97%****]
Dictyostelium discoideum_AX4@XP_638767[RRM1][KOG0123]Ciona intestinalis@ENSCINP00000017840[RRM1][KOG0109]
Gammaproteobacteria@YP_113294[2][RRM1:100%][PROK:100%]Euteleostomi@ENSDNOP00000012760[63][RRM2:94%****][.RRM1:6%*][LARK:65%***][.RBM:21%**][KOG0109:97%****]
Ciona intestinalis@ENSCINP00000017840[RRM2][KOG0109]Endopterygota@CG8597-PE[8][RRM2:100%**][LARK:62%*][KOG0109:100%**]
Danio rerio@ENSDARP00000065401[RRM2][KOG0109]Ciona savignyi@ENSCSAVP00000008315[4][RRM1:100%*][KOG0108:100%*]
Theileria parva_strain_Muguga@XP_765374[RRM1]Cryptosporidium parvum_Iowa_II@XP_001388131[RRM1][KOG1015]
Dictyostelium discoideum_AX4@XP_643642[RRM1][KOG0148]Saccharomycetales@YHL034C[2][RRM1:100%]
Pichia stipitis_CBS_6054@XP_001387063[RRM1]Schizosaccharomyces pombe_972h-@NP_593427[RRM1][KOG0123]
Kluyveromyces lactis@XP_454447[RRM3][KOG0128]Embryophyta@28180_m000395[3][RRM1:100%*][KOG0124:100%*]
Arabidopsis thaliana@NP_191094[RRM1][KOG4205]Theileria parva_strain_Muguga@XP_765374[RRM2]
Yarrowia lipolytica@XP_504884[RRM3][KOG0123]Aedes aegypti@AAEL010807-PA[RRM1][put-sr][KOG1080]
Euteleostomi@ENSORLP00000016244[7][RRM1:100%*][KOG1080:57%*]Saccharomyces cerevisiae@YOR319W[RRM2][KOG0131]
51 - LARK
part of 35 - G3BP
RBM
30K RRM
hnRNP
Musashi
Dazap
TARDBP
OligoU
1
74
87 - eIF-4B
Fig. S5
70
59
67 52
63
99
100
55
65
83
64
64
62
60
59
57
65
94
98 70
82
54
68
63
75
61
Ostreococcus lucimarinus@jgi Ost9901 3 8794[RRM1][KOG0105]Plasmodium falciparum_3D7@XP_001351730[RRM1][put-sr][KOG0105]Phytophthora@jgi_Physo1_1_140403[2][RRM1:100%][put-sr:100%][KOG0127:100%]
Cyanidioschyzon merolae@gnl_CMER_CMO009C[RRM2]Yarrowia lipolytica@XP_500797[RRM1][put-sr]
Ustilago maydis_521@XP_758616[RRM1]Schizosaccharomyces pombe_972h-@NP_596398[RRM1][put-sr][SR]
Cryptosporidium parvum_Iowa_II@XP_627232[RRM1][put-sr][KOG0105]Eukaryota@ENSTBEP00000007356[92][RRM1:100%****][put-sr:82%****][SR:65%****][KOG0105:100%****]
Phytophthora@jgi_Physo1_1_138982[2][RRM1:100%][KOG0105:100%]Theileria parva_strain_Muguga@XP_766386[RRM1][put-sr][KOG0105]
Ciona intestinalis@ENSCINP00000016525[RRM1][put-sr][KOG0106]Cavia porcellus@ENSCPOP00000010577[RRM1][put-sr][SR][KOG0106]
Eukaryota@ENSOANP00000021053[127][RRM1:100%****][put-sr:91%****][SR:61%****][KOG0106:55%****][.KOG0105:37%***]Aedes aegypti@AAEL012621-PA[RRM1][put-sr][KOG0105]
Caenorhabditis elegans@T28D9_2a[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*]Strongylocentrotus purpuratus@XP_001185906[2][RRM1:100%][KOG0107:100%]
Dictyostelium discoideum_AX4@XP_001134500[RRM1][put-sr][KOG0147]Cryptococcus neoformans_var._neoformans_JEC21@XP_567562[RRM1][KOG0106]
Schizosaccharomyces pombe_972h-@NP_594570[RRM1][put-sr][KOG0106]Neurospora crassa_OR74A@XP_960334[RRM1][put-sr][KOG0105]
Phytophthora@jgi_Physo1_1_129427[2][RRM2:100%][KOG0110:100%]Caenorhabditis elegans@T23F6_4_1[2][RRM3:100%][KOG0110:100%]
Ustilago maydis_521@XP_758493[RRM2][KOG0110]Aureococcus anophagefferens@jgi_Auran1_1296[RRM1][KOG0110]
Neurospora crassa_OR74A@XP_965014[RRM2][KOG0110]Phaeodactylum tricornutum@jgi_Phatr2_20740[RRM2][KOG0110]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569873[RRM2][KOG0110]Saccharomycetales@NP_984131[7][RRM2:100%*][KOG0110:100%*]
Aspergillus fumigatus_Af293@XP_750233[RRM2][KOG0110]Schizosaccharomyces pombe_972h-@NP_595599[RRM2][KOG0110]
Strongylocentrotus purpuratus@XP_783689[2][RRM2:100%][KOG0127:100%]Oryza sativa_japonica_cultivar-group@NP_001053839[RRM1][KOG0110]
Phytophthora sojae@jgi_Physo1_1_132702[RRM4][KOG0127]Phytophthora ramorum@jgi_Phyra1_1_79608[2][RRM4:100%][KOG0127:100%]
Chlamydomonas reinhardtii@jgi_Chlre3_181993[RRM1]Geobacter uraniumreducens_Rf4@YP_001230384[RRM1][PROK][KOG0108]
Bacillariophyta@jgi_Phatr2_8451[2][RRM1:100%][KOG0108:100%]Oryza sativa_japonica_cultivar-group@NP_001058465[RRM1][KOG0108]
Aureococcus anophagefferens@jgi_Auran1_23269[RRM1][KOG0108]Saccharomycetaceae@XP_001383390[2][RRM1:100%][KOG0108:100%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572946[RRM1][KOG0108]Neurospora crassa_OR74A@XP_965346[RRM2][KOG0110]
Aspergillus fumigatus_Af293@XP_747328[RRM2][KOG0110]Yarrowia lipolytica@XP_505184[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_44395[RRM1]
Yarrowia lipolytica@XP_499736[RRM2][KOG4205]Schizosaccharomyces pombe_972h-@NP_594970[RRM2][KOG4210]
Saccharomycetales@NP_982813[6][RRM2:100%*][KOG4210:100%*]Aspergillus fumigatus_Af293@XP_755020[RRM2]
Saccharomycetales@XP_001385462[7][RRM3:100%*][KOG0127:100%*]Basidiomycota@XP_756663[3][RRM4:67%][.RRM3:33%][KOG0127:100%*]
Schizosaccharomyces pombe_972h-@NP_596114[RRM3][KOG0127]Sordariomycetes@XP_962933[2][RRM3:100%][KOG0127:100%]
Aspergillus fumigatus_Af293@XP_752199[RRM3][KOG0127]Phaeodactylum tricornutum@jgi_Phatr2_8457[RRM1][KOG0122]
Physcomitrella patens@jgi_Phypa1_1_201182[RRM3][KOG0127]Physcomitrella patens@jgi_Phypa1_1_204078[RRM1][KOG0116]
Magnoliophyta@NP_001052571[5][RRM1:100%*][KOG0116:100%*]Arabidopsis thaliana@NP_189151[RRM1][NTF][KOG0116]
Saccharomycetales@NP_986417[7][RRM1:100%*][KOG0127:100%*]Phytophthora@jgi_Physo1_1_132702[3][RRM1:100%*][KOG0127:100%*]
Ostreococcus@jgi_Ostta4_19569[2][RRM3:100%][KOG0127:100%]Chlamydomonadales@jgi_Volca1_87629[2][RRM3:100%][KOG0127:100%]
Magnoliophyta@30131_m007093[6][RRM3:83%*][.RRM2:17%][KOG0127:100%*]Dictyostelium discoideum_AX4@XP_646584[RRM3][KOG0127]
Ostreococcus tauri@jgi_Ostta4_19569[RRM1][KOG0127]Ostreococcus lucimarinus@jgi_Ost9901_3_26255[RRM1][KOG0127]
Embryophyta@NP_001062111[8][RRM1:100%**][put-sr:62%*][KOG4849:38%*][.KOG4246:12%][.KOG0113:12%][.KOG4676:12%]Ostreococcus lucimarinus@jgi_Ost9901_3_26750[RRM1]
Aureococcus anophagefferens@jgi_Auran1_67810[RRM1][put-sr][KOG0120]Aureococcus anophagefferens@jgi_Auran1_60739[RRM1][put-sr][KOG1860]
Cryptosporidium parvum_Iowa_II@XP_627975[RRM1][KOG0108]Theileria parva_strain_Muguga@XP_766096[RRM1]Plasmodium falciparum_3D7@XP_001352196[RRM1][KOG0108]
Culicidae@AAEL001997-PA[2][RRM1:100%]Drosophila melanogaster@CG3594-PA[RRM1][KOG0110]
Saccharomycetaceae@XP_001385249[2][RRM1:100%][KOG0113:100%]Saccharomycetales@NP_984033[3][RRM1:100%*][KOG0113:100%*]Kluyveromyces lactis@XP_452557[RRM1][KOG0113]
Yarrowia lipolytica@XP_503802[RRM1][KOG0113]Euteleostomi@ENSGALP00000013474[20][RRM5:85%**][.RRM4:5%][.RRM3:5%][.RRM2:5%][put-sr:10%][KOG0110:100%**]
Culicidae@AAEL004075-PA[3][RRM5:67%][.RRM1:33%][KOG0110:100%*]Ostreococcus@jgi_Ost9901_3_710[2][RRM4:100%][KOG0110:100%]Magnoliophyta@NP_193696[2][RRM3:100%][KOG0110:100%]
Apocrita@XP_001605134[2][RRM5:100%][KOG0110:100%]Phytophthora sojae@jgi_Physo1_1_129427[RRM4][KOG0110]Cryptococcus neoformans_var._neoformans_JEC21@XP_569873[RRM4][KOG0110]
Thalassiosira pseudonana@jgi_Thaps3_268689[RRM4][KOG0110]Phaeodactylum tricornutum@jgi_Phatr2_20740[RRM4][KOG0110]
Ascomycota@XP_001386803[10][RRM4:90%**][.RRM2:10%][KOG0110:100%**]Cryptosporidium parvum_Iowa_II@XP_627799[RRM4][KOG0110]
Deuterostomia@XP_001178221[30][RRM1:100%***][put-sr:63%**][snRNP:70%***][KOG0113:100%***]Ciona@ENSCSAVP00000001345[2][RRM1:100%][KOG0113:100%]
Embryophyta@29657_m000467[4][RRM1:100%*][put-sr:50%][snRNP:25%][KOG0113:100%*]Tribolium castaneum@XP_966565[RRM1][KOG0113]
Cryptosporidium parvum_Iowa_II@XP_627471[RRM1][KOG0113]Phytophthora@jgi_Phyra1_1_44765[2][RRM1:100%][put-sr:50%][KOG0113:100%]
Coelomata@AAEL011340-PB[2][RRM1:100%][put-sr:50%][KOG0113:100%]Rattus norvegicus@ENSRNOP00000048879[RRM1][snRNP][KOG0113]
Felis catus@ENSFCAP00000006212[RRM1][put-sr][KOG0113]Ostreococcus@jgi_Ostta4_11066[2][RRM1:100%][KOG0113:100%]Eukaryota@jgi_Physo1_1_143842[43][RRM1:100%***][put-sr:47%**][snRNP:14%*][KOG0113:100%***]
Aureococcus anophagefferens@jgi_Auran1_34517[2][RRM1:100%][put-sr:50%][KOG0113:100%]Schizosaccharomyces pombe_972h-@NP_593779[RRM1][KOG0113]Sordariomycetes@XP_959061[2][RRM1:100%][KOG0113:100%]
Aspergillus fumigatus_Af293@XP_753306[RRM1][KOG0113]Trypanosomatidae@XP_001463723[2][RRM1:100%][KOG0110:100%]
Drosophila melanogaster@CG2050-PA[RRM2]Theileria parva_strain_Muguga@XP_765501[RRM1][KOG0127]
Percomorpha@ENSGACP00000011877[6][RRM1:100%*][KOG0123:100%*]Gallus gallus@ENSGALP00000012472[2][RRM1:100%][KOG0123:100%]
Thalassiosira pseudonana@jgi_Thaps3_1374[RRM2][KOG0116]Phaeodactylum tricornutum@jgi_Phatr2_44442[RRM2][KOG4211]
Encephalitozoon cuniculi_GB-M1@NP_597583[RRM1][KOG4205]Cryptosporidium parvum_Iowa_II@XP_001388131[RRM2][KOG1015]
Schizosaccharomyces pombe_972h-@NP_596518[RRM1][KOG0116]Dictyostelium discoideum_AX4@XP_638767[RRM2][KOG0123]
Aedes aegypti@AAEL012119-PA[RRM1]Plasmodium falciparum_3D7@XP_001352039[RRM1][KOG0144]
36 - snRNP
59
16 - dual-RRM
SR proteins
Fungal SR (SpSrp1)
Fungal SR (SpSrp2)
Fig. S5
71
100
99
79
84
51
57
79
85
62
62
53
63
58
99
98
50
60
89
96
65
76
Phytophthora ramorum@jgi Phyra1 1 73884[RRM1][KOG4205]Bilateria@ENSRNOP00000022054[326][RRM1:100%*****][hnRNP:54%*****][KOG4205:100%*****]
Cryptosporidium parvum_Iowa_II@XP_628599[RRM2][KOG4205]Plasmodium falciparum_3D7@XP_001352039[RRM2][KOG0144]
Cryptosporidium parvum_Iowa_II@XP_626158[RRM2][KOG0144]Ciona intestinalis@ENSCINP00000029053[RRM1][KOG4205]
Ciona intestinalis@ENSCINP00000006182[RRM1][KOG4205]Strongylocentrotus purpuratus@XP_001176409[2][RRM1:100%][KOG4205:100%]
Strongylocentrotus purpuratus@XP_001189292[2][RRM1:100%][KOG4205:100%]Aureococcus anophagefferens@jgi_Auran1_6078[RRM1][KOG4205]
Coelomata@SINFRUP00000146060[58][RRM1:100%****][TARDBP:72%***][KOG4205:98%****]Strongylocentrotus purpuratus@XP_789716[2][RRM1:100%][KOG4205:100%]
Oryctolagus cuniculus@ENSOCUP00000001170[RRM1][hnRNP][KOG4205]Myotis lucifugus@ENSMLUP00000003070[RRM1][hnRNP][KOG4205]
Chlamydomonadales@jgi_Volca1_107445[2][RRM1:100%][KOG4205:100%]Cyanidioschyzon merolae@gnl_CMER_CMR392C[RRM1][KOG4205]Ciona@ENSCINP00000012771[9][RRM1:100%**][put-sr:11%][KOG4205:100%**]
Eukaryota@jgi_Ostta4_3181[66][RRM1:100%****][put-sr:47%***][cyclophilin:32%***][KOG0415:97%****]Debaryomyces hansenii_CBS767@XP_459815[RRM1][KOG0415]
Chlamydomonadales@jgi_Chlre3_181880[2][RRM2:100%][KOG4205:100%]Drosophila melanogaster@CG9654-PA[RRM1][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_001388284[RRM1][KOG4205]Ustilago maydis_521@XP_758567[RRM2][KOG4205]
Thalassiosira pseudonana@jgi_Thaps3_25203[2][RRM1:100%][KOG4205:100%]Phaeodactylum tricornutum@jgi_Phatr2_41450[RRM1][KOG4205]
Strongylocentrotus purpuratus@NP_999784[3][RRM1:100%*][KOG4205:100%*]Embryophyta@jgi_Phypa1_1_112860[6][RRM2:100%*][put-sr:17%][KOG4205:100%*]
Chlamydomonadales@jgi_Chlre3_105806[2][RRM2:100%][KOG4205:100%]Embryophyta@jgi_Phypa1_1_156290[6][RRM1:100%*][put-sr:17%][KOG4205:100%*]
Phaeodactylum tricornutum@jgi_Phatr2_21039[RRM2][KOG4205]Embryophyta@28611_m000102[4][RRM2:100%*][put-sr:75%*][KOG0154:100%*]
Anopheles gambiae@AGAP007689-PA[RRM1]Aedes aegypti@AAEL010101-PA[RRM1]
Saccharomycetaceae@XP_458658[2][RRM1:100%][KOG0921:100%]Aureococcus anophagefferens@jgi_Auran1_6342[RRM2][KOG0123]
Eukaryota@jgi_Phatr2_8132[54][RRM1:100%***][KOG0114:100%***]Theileria parva_strain_Muguga@XP_766722[RRM1][KOG0144]
Plasmodium falciparum_3D7@XP_001349292[RRM1][KOG0146]Pichia stipitis_CBS_6054@XP_001384763[RRM3][KOG0123]
Apocrita@XP_623710[2][RRM1:100%]Euteleostomi@ENSOANP00000024755[113][RRM1:100%****][hnRNP:36%***][.RALYL:15%**]
Leishmania infantum_JPCM5@XP_001468615[RRM1]Dictyostelium discoideum_AX4@XP_647083[RRM1]
Cryptococcus neoformans_var._neoformans_JEC21@XP_567374[RRM1][KOG0307]Embryophyta@30128_m008555[15][RRM1:100%**][KOG4660:100%**]
Chlamydomonas reinhardtii@jgi_Chlre3_152680[RRM1][KOG4660]Eukaryota@NP_001053839[55][RRM6:42%***][.RRM5:35%**][.RRM4:11%*][.RRM3:9%*][KOG0110:100%****]
Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM5][KOG0110]Encephalitozoon cuniculi_GB-M1@NP_597181[RRM3][KOG0110]
Plasmodium falciparum_3D7@XP_001350574[RRM3][KOG0110]Cryptosporidium parvum_Iowa_II@XP_627799[RRM5][KOG0110]
Saccharomycetales@YNL016W[6][RRM3:100%*][put-sr:33%][KOG0148:83%*][.KOG0123:17%]Tribolium castaneum@XP_967803[2][RRM1:100%][KOG0117:100%]Eutheria@ENSCPOP00000011171[3][RRM1:100%*][hnRNP:67%][KOG0117:100%*]Bilateria@ENSGALP00000025475[210][RRM1:100%*****][hnRNP:33%****][KOG0117:100%*****]Rattus norvegicus@ENSRNOP00000053644[RRM1][KOG0117]
Aedes aegypti@AAEL015050-PA[2][RRM1:100%][KOG0117:100%]Eutheria@ENSBTAP00000025092[6][RRM1:100%*][KOG0117:100%*]
Gasterosteus aculeatus@ENSGACP00000025947[RRM1][KOG0117]Anopheles gambiae@AGAP002326-PA[RRM1]
Clupeocephala@ENSORLP00000002364[10][RRM2:100%**][KOG0109:100%**]Phaeodactylum tricornutum@jgi_Phatr2_16633[RRM1][KOG0125]
Neurospora crassa_OR74A@XP_958552[RRM3][KOG0128]Phytophthora@jgi_Phyra1_1_75647[2][RRM1:100%]
Ciona@ENSCSAVP00000017501[2][RRM1:50%][.RRM2:50%][KOG0109:50%]Saccharomycetales@XP_446998[3][RRM1:100%*][KOG0122:100%*]Saccharomycetaceae@XP_001388004[2][RRM1:100%][KOG0122:100%]
Yarrowia lipolytica@XP_503515[RRM1][KOG0122]Caenorhabditis elegans@F22B5_2[RRM1][KOG0122]
Cryptococcus neoformans_var._neoformans_JEC21@XP_567824[RRM1][KOG0122]Eukaryota@NP_187747[49][RRM1:100%***][KOG0122:98%***]
Medicago truncatula@IMGA_AC144431_18_2[RRM1][KOG0122]Apicomplexa@XP_001388056[3][RRM1:100%*][KOG0122:100%*]
Cyanidioschyzon merolae@gnl_CMER_CMH159C[RRM1][KOG0122]Eukaryota@NP_001063859[35][RRM1:100%***][ZCRB1:69%***][KOG0108:40%**][.KOG0122:9%*][.KOG0117:6%][.KOG0107:6%]
Phytophthora ramorum@jgi_Phyra1_1_94226[RRM1][put-sr][KOG0941]Drosophila melanogaster@CG5213-PA[RRM2][KOG0145]
Chlamydomonadales@jgi_Volca1_72841[2][RRM3:50%][.RRM2:50%][KOG0144:100%]Chlamydomonadales@jgi_Chlre3_99329[2][RRM1:50%][.RRM2:50%][KOG0144:100%]
Volvox carteri@jgi_Volca1_72841[RRM1][KOG0144]Embryophyta@30076_m004622[9][RRM1:100%**][FCAFPA:22%][KOG0144:100%**]
Medicago truncatula@IMGA_AC155099_2_2[2][RRM1:100%][KOG0144:100%]Arabidopsis thaliana@NP_850472[RRM1][FCAFPA][KOG0144]
Poaceae@11320_m000014_AZM5_6848[3][RRM1:100%*][KOG0144:100%*]Dictyostelium discoideum_AX4@XP_635247[RRM1][KOG0144]
Physcomitrella patens@jgi_Phypa1_1_107590[2][RRM1:100%][KOG0144:100%]Cryptosporidium parvum_Iowa_II@XP_628265[RRM1][KOG0144]Chlamydomonadales@jgi_Volca1_118581[3][RRM2:67%][.RRM4:33%][KOG0144:67%][.KOG1240:33%]
Volvox carteri@jgi_Volca1_88093[RRM4][KOG1240]Thalassiosira pseudonana@jgi_Thaps3_261541[RRM1][KOG0144]
Phaeodactylum tricornutum@jgi_Phatr2_42828[RRM1][KOG0144]Phytophthora@jgi_Phyra1_1_82644[2][RRM1:100%][KOG0144:100%]
Coelomata@XP_782270[24][RRM1:100%***][Bruno:42%**][KOG0144:100%***]Bilateria@ENSXETP00000031370[81][RRM1:100%****][Bruno:42%***][KOG0146:84%****][.KOG0144:16%**]
Cryptosporidium parvum_Iowa_II@XP_001388078[RRM1][put-sr][KOG0144]Theileria parva_strain_Muguga@XP_766017[RRM1][KOG0144]
Plasmodium falciparum_3D7@XP_001350299[RRM1][KOG0144]Trypanosomatidae@XP_827838[2][RRM1:100%][KOG0144:100%]
Trypanosomatidae@XP_845656[2][RRM1:100%][KOG0131:50%]Trypanosomatidae@XP_001468238[3][RRM1:100%*][KOG0144:100%*]
Leishmania infantum_JPCM5@XP_001468236[RRM1]Aconoidasida@XP_766017[2][RRM2:100%][KOG0144:100%]
Plasmodium falciparum_3D7@XP_001348269[RRM2][KOG0144]Cryptosporidium parvum_Iowa_II@XP_001388078[RRM2][put-sr][KOG0144]Embryophyta@jgi_Phypa1_1_115029[9][RRM2:100%**][KOG0144:100%**]
Bilateria@AGAP009477-PA[250][RRM2:73%*****][.RRM1:27%****][Bruno:59%****][KOG0144:56%****][.KOG0146:44%****]Trypanosomatidae@XP_001468777[2][RRM2:100%][KOG0144:100%]
Cryptosporidium parvum_Iowa_II@XP_628265[RRM2][KOG0144]Embryophyta@29889_m003323[11][RRM2:100%**][FCAFPA:18%][KOG0144:100%**]
Arabidopsis thaliana@NP_850472[RRM2][FCAFPA][KOG0144]Phytophthora@jgi_Physo1_1_133760[2][RRM2:100%][KOG0144:100%]
Thalassiosira pseudonana@jgi_Thaps3_261541[RRM2][KOG0144]Dictyostelium discoideum_AX4@XP_646268[RRM2][KOG0146]
Dictyostelium discoideum_AX4@XP_635247[RRM2][KOG0144]Chlamydomonadales@jgi_Volca1_88093[2][RRM1:100%][KOG1240:100%]
Chlamydomonas reinhardtii@jgi_Chlre3_174860[RRM2][KOG1240]Gammaproteobacteria@YP_561253[27][RRM1:100%***][PROK:100%***][KOG0108:96%***]Alkalilimnicola ehrlichei_MLHE-1@YP_741458[RRM1][PROK]Embryophyta@NP_194280[13][RRM1:100%**][put-sr:77%**][SR:62%**][KOG0106:100%**]
Ostreococcus lucimarinus@jgi_Ost9901_3_8794[RRM1][KOG0105]
8 - Bruno
FCA FPA
7 - Bruno
FCA FPA
65
2 - hnRNP
60
45
38 - cyclophilin
86 - hnRNP
RALYL44
42
57 - ZCRB1
g ( p p )
Fig. S5
72
68
72
72
71
59
94
96
94
97
60
60
Pezizomycotina@XP 961985[2][RRM1:100%][KOG0116:50%]Aureococcus anophagefferens@jgi_Auran1_69134[RRM1][put-sr]
Caenorhabditis elegans@C50B8_1[RRM1]Embryophyta@jgi_Phypa1_1_44443[2][RRM2:100%][KOG0149:100%]
Embryophyta@29900_m001607[13][RRM2:100%**][oligoU:38%*][KOG4205:77%**][.KOG0149:23%*]Caenorhabditis elegans@C07A4_1[RRM2][KOG0148]
Coelomata@CG4787-PA[102][RRM3:74%****][.RRM2:16%**][.RRM1:11%**][TIATIAR:75%****][KOG0148:100%****]Caenorhabditis elegans@Y46G5A_13[10][RRM2:80%**][.RRM3:20%][KOG0148:100%**]
Diptera@AGAP003899-PA[15][RRM2:100%**][KOG0145:100%**]Coelomata@XP_974651[54][RRM2:83%***][.RRM1:17%**][put-sr:87%***][RBM:37%**][KOG0112:100%***]
Saccharomyces cerevisiae@YMR302C[RRM1]Nasonia vitripennis@XP_001604488[RRM1]
Ascomycota@YDL224C[8][RRM1:88%*][.RRM2:12%][KOG3598:12%][.KOG1457:12%]Chlamydomonas reinhardtii@jgi_Chlre3_145376[RRM2]Methanomicrobiales@YP_503016[5][RRM1:100%*][PROK:100%*][KOG0108:40%][.KOG0125:20%][.KOG0116:20%]Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM1][put-sr][KOG0147]
Physcomitrella patens@jgi_Phypa1_1_161310[RRM3][KOG3598]Embryophyta@NP_001063403[14][RRM1:100%**][KOG0148:100%**]
Endopterygota@XP_974444[2][RRM1:100%][KOG0144:100%]Clupeocephala@ENSORLP00000016619[5][RRM1:100%*][KOG0131:60%*][.KOG0123:40%]
Phaeodactylum tricornutum@jgi_Phatr2_38474[RRM1]Ustilago maydis_521@XP_760296[RRM1]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572996[RRM1]Ricinus communis@30169_m006629[RRM1][KOG0123]
Euteleostomi@ENSOANP00000013028[22][RRM1:100%***]Endopterygota@XP_967886[3][RRM1:100%*]
Drosophila melanogaster@CG14414-PB[RRM1]Chlamydomonadales@jgi_Volca1_43575[2][RRM3:100%][KOG4205:100%]Embryophyta@NP_001067623[8][RRM1:100%**][KOG0117:100%**]
Dictyostelium discoideum_AX4@XP_640243[RRM1][KOG0117]Eukaryota@AAEL002461-PA[78][RRM1:100%****][put-sr:29%***][KOG0126:100%****]
Saccharomycetaceae@XP_459205[2][RRM1:100%][KOG0126:100%]Ustilago maydis_521@XP_760864[RRM1][KOG0126]
Caenorhabditis elegans@Y73B6BL_6a_3[10][RRM2:100%**][KOG4205:100%**]Ciona@ENSCSAVP00000016637[3][RRM2:100%*][KOG4205:100%*]
Ciona@ENSCINP00000028810[2][RRM2:100%][KOG4205:100%]Euteleostomi@ENSSTOP00000002923[18][RRM1:100%**][KOG4205:11%]
Strongylocentrotus purpuratus@XP_001188704[2][RRM1:100%][KOG0149:100%]Phaeodactylum tricornutum@jgi_Phatr2_49481[RRM1][KOG1337]
Strongylocentrotus purpuratus@XP_789716[2][RRM2:100%][KOG4205:100%]Strongylocentrotus purpuratus@XP_780859[2][RRM2:100%][KOG4205:100%]
Oryza sativa_japonica_cultivar-group@NP_001058805[RRM1][KOG4205]Chlamydomonadales@jgi_Chlre3_105806[2][RRM1:100%][KOG4205:100%]
Aureococcus anophagefferens@jgi_Auran1_9576[RRM1][KOG0149]Ricinus communis@28976_m000161[RRM1][KOG4205]
Ricinus communis@30170_m013671[RRM1][KOG4205]Arabidopsis thaliana@NP_176143[RRM1][KOG4205]
Zea mays@14684_m000016_AZM5_14964[RRM1][KOG4205]Oryza sativa_japonica_cultivar-group@NP_001051402[RRM1][KOG0149]
Phytophthora sojae@jgi_Physo1_1_139371[RRM2][KOG4205]Cyanidioschyzon merolae@gnl_CMER_CMR392C[RRM2][KOG4205]
Ostreococcus tauri@jgi_Ostta4_33731[RRM2]Ostreococcus tauri@jgi_Ostta4_33731[RRM1]
Oryza sativa_japonica_cultivar-group@NP_001064224[RRM1][KOG0117]Magnoliophyta@29709_m001182[6][RRM1:100%*][put-sr:17%][KOG0117:100%*]
Ricinus communis@30072_m000974[RRM1][KOG0117]Physcomitrella patens@jgi_Phypa1_1_140180[3][RRM1:100%*][KOG0117:100%*]
Phytophthora sojae@jgi_Physo1_1_139371[RRM1][KOG4205]Oryza sativa_japonica_cultivar-group@NP_001054022[RRM1][KOG4205]
Magnoliophyta@NP_001042672[10][RRM1:100%**][oligoU:50%*][KOG4205:80%**][.KOG0149:20%]Arabidopsis thaliana@NP_850021[4][RRM1:100%*][oligoU:100%*][KOG0149:75%*][.KOG2186:25%]
Takifugu rubripes@SINFRUP00000163373[RRM1][KOG0149]Takifugu rubripes@SINFRUP00000145256[RRM1][KOG0149]
Arabidopsis thaliana@NP_187353[RRM1][30kRRM][KOG0149]Eukaryota@NP_001058102[93][RRM1:100%****][RBM:52%***][.30kRRM:13%**][KOG0149:96%****]Arabidopsis thaliana@NP_200183[2][RRM1:100%][oligoU:100%][KOG0149:100%]
Dictyostelium discoideum_AX4@XP_629598[RRM2][KOG4205]Dictyostelium discoideum_AX4@XP_643377[RRM1][KOG3598]
Caenorhabditis elegans@F56D1_7[RRM1]Euteleostomi@ENSEEUP00000005436[64][RRM1:95%****]Coelomata@AAEL001684-PA[39][RRM1:100%***][KOG0125:21%**]
Takifugu rubripes@SINFRUP00000155469[RRM1]Tupaia belangeri@ENSTBEP00000015084[RRM1]
Spermophilus tridecemlineatus@ENSSTOP00000003171[RRM1]Strongylocentrotus purpuratus@XP_798256[2][RRM1:100%][KOG2277:100%]
Oryzias latipes@ENSORLP00000005442[2][RRM1:100%][KOG2277:100%]Xenopus tropicalis@ENSXETP00000012439[RRM1][KOG2277]
Oryctolagus cuniculus@ENSOCUP00000014792[RRM1][KOG2277]Ostreococcus lucimarinus@jgi_Ost9901_3_24530[RRM1][KOG4205]Oryza sativa_japonica_cultivar-group@NP_001067093[RRM1][KOG4177]
Strongylocentrotus purpuratus@NP_999784[3][RRM2:100%*][KOG4205:100%*]Endopterygota@AAEL008257-PA[8][RRM2:100%**][KOG4205:100%**]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568675[RRM2][KOG4205]Embryophyta@IMGA_AC144431_42_2[6][RRM3:100%*][put-sr:17%][KOG4205:100%*]
Theileria parva_strain_Muguga@XP_766400[RRM1][put-sr][KOG4205]Plasmodium falciparum_3D7@XP_001351452[RRM2][KOG4205]
Plasmodium falciparum_3D7@XP_001347758[RRM2][KOG0149]Plasmodium falciparum_3D7@XP_001347758[RRM1][KOG0149]
Euteleostomi@ENSDARP00000005968[129][RRM2:95%****][.RRM1:5%*][hnRNP:57%****][KOG4205:100%****]Eukaryota@AGAP006656-PA[121][RRM2:88%****][.RRM1:12%**][Musashi:36%***][.Dazap:21%***][.hnRNP:10%**][KOG4205:100%****]
Ciona@ENSCSAVP00000001921[3][RRM2:100%*][Musashi:67%][KOG4205:100%*]Phytophthora ramorum@jgi_Phyra1_1_73884[RRM2][KOG4205]
Endopterygota@XP_001121454[19][RRM2:100%**][KOG4205:100%**]Strongylocentrotus purpuratus@XP_001176409[2][RRM2:100%][KOG4205:100%]
Viridiplantae@NP_851001[17][RRM2:100%**][put-sr:12%][KOG4205:94%**][.KOG1833:6%]Cryptococcus neoformans_var._neoformans_JEC21@XP_566745[2][RRM1:100%]
Endopterygota@CG16901-PC[19][RRM1:100%**][KOG4205:100%**]Bacillariophyta@jgi_Phatr2_21039[2][RRM1:100%][KOG4205:100%]
Kluyveromyces lactis@XP_453971[RRM1]Strongylocentrotus purpuratus@XP_001183095[2][RRM2:100%][KOG4205:100%]
Caenorhabditis elegans@Y73B6BL_6b_3[10][RRM1:100%**][KOG4205:100%**]Plasmodium falciparum_3D7@XP_001351452[RRM1][KOG4205]
Coelomata@CG6354-PB[373][RRM2:95%*****][hnRNP:53%*****][KOG4205:100%*****]Drosophila melanogaster@CG9654-PA[RRM2][KOG4205]
Caenorhabditis elegans@F42A6_7a_1[8][RRM2:100%**][KOG4205:100%**]Sorex araneus@ENSSARP00000008097[RRM2][hnRNP][KOG4205]
Ciona@ENSCINP00000008394[8][RRM2:100%**][KOG4205:100%**]Ciona intestinalis@ENSCINP00000012771[RRM2][put-sr][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_626025[RRM1][KOG4205]Chlamydomonadales@jgi_Volca1_107445[2][RRM2:100%][KOG4205:100%]
Ascomycota@XP_961230[5][RRM2:100%*][put-sr:20%][KOG4205:100%*]Encephalitozoon cuniculi_GB-M1@NP_597487[RRM1][KOG4205]
Saccharomycetales@XP_449511[7][RRM2:100%*][KOG4205:100%*]Ricinus communis@28976_m000161[RRM2][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_001388284[RRM2][KOG4205]Physcomitrella patens@jgi_Phypa1_1_19696[RRM1][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_626579[RRM2][KOG4205]Cryptosporidium parvum_Iowa_II@XP_626025[RRM2][KOG4205]
Eukaryota@ENSMODP00000031317[289][RRM1:100%*****][hnRNP:28%****][.Musashi:13%***][.Dazap:9%***][KOG4205:99%*****]Phytophthora ramorum@jgi_Phyra1_1_73884[RRM1][KOG4205]
34
35 - G3BP
RBM
30K-RRM
hnRNP
Musashi
Dazap
TARDBP
OligoU
62
62
69
53 - RBM
79 - TIA TIAR
OligoU
Fig. S5
73
53
51
100
99
97
97
Eukaryota@8925 m000027 AZM5 1178[67][RRM1:100%****][put sr:84%****][SR:61%***][KOG4207:61%***][ KOG4368:24%**]Bacillariophyta@jgi_Thaps3_23196[2][RRM1:100%][KOG4207:50%]
Phytophthora sojae@jgi_Physo1_1_138511[RRM1][put-sr]Ostreococcus@jgi_Ostta4_7793[2][RRM1:100%][KOG0108:100%]
Ostreococcus lucimarinus@jgi_Ost9901_3_8174[RRM1][KOG4207]Yarrowia lipolytica@XP_500351[RRM1][KOG0123]Chlamydomonadales@jgi_Volca1_90315[3][RRM2:67%][.RRM3:33%][KOG0123:67%]
Thalassiosira pseudonana@jgi_Thaps3_33709[RRM1][KOG0111]Bacillariophyta@jgi_Thaps3_19374[2][RRM1:100%][KOG0121:100%]
Encephalitozoon cuniculi_GB-M1@NP_597585[RRM1][KOG0121]Theileria parva_strain_Muguga@XP_766484[RRM1][KOG0121]
Cryptosporidium parvum_Iowa_II@XP_627536[RRM1][KOG0121]Trypanosomatidae@XP_001466901[2][RRM1:100%][KOG0121:100%]
Eukaryota@ENSMODP00000034858[66][RRM1:100%****][KOG0121:100%****]Plasmodium falciparum_3D7@XP_001351463[RRM1][KOG0121]
Dictyostelium discoideum_AX4@XP_641373[RRM1][put-sr]Aureococcus anophagefferens@jgi_Auran1_17018[RRM1][KOG0111]Encephalitozoon cuniculi_GB-M1@NP_586226[RRM1][put-sr][KOG0123]
Dictyostelium discoideum_AX4@XP_641568[RRM3][KOG3598]Trypanosomatidae@XP_827855[2][RRM1:100%]
Tribolium castaneum@XP_969873[RRM1]Theileria parva_strain_Muguga@XP_766728[RRM1][KOG0124]
Theileria parva_strain_Muguga@XP_765867[RRM1][KOG0111]Trypanosoma brucei_TREU927@XP_951655[RRM2][put-sr][KOG0109]
Leishmania infantum_JPCM5@XP_001466413[RRM2][put-sr][KOG0147]Trypanosomatidae@XP_847474[2][RRM1:100%]Trypanosomatidae@XP_001467105[2][RRM1:100%][KOG4209:100%]Culicidae@AGAP003171-PA[3][RRM2:100%*][KOG0148:33%]
Drosophila melanogaster@CG12288-PA[RRM2]Candida glabrata_CBS138@XP_446891[RRM3][KOG0128]
Plasmodium falciparum_3D7@XP_001352080[RRM2]Apis mellifera@XP_394565[RRM1][KOG0147]
Coelomata@ENSMUSP00000057332[45][RRM1:100%***][put-sr:100%***][RNPS1:64%***][KOG4209:87%***]Cryptococcus neoformans_var._neoformans_JEC21@XP_569824[RRM1][put-sr]
Sordariomycetes@XP_001522188[3][RRM1:100%*][put-sr:67%]Schizosaccharomyces pombe_972h-@NP_596549[RRM1][put-sr]
Dictyostelium discoideum_AX4@XP_636445[RRM1][put-sr]Viridiplantae@jgi_Phypa1_1_105411[8][RRM1:100%**][put-sr:100%**][SR:25%][KOG0117:12%][.KOG0462:12%]
Caenorhabditis elegans@K02F3_11_2[2][RRM1:100%][put-sr:100%][KOG4209:100%]Schizosaccharomyces pombe_972h-@NP_595090[RRM1]
Physcomitrella patens@jgi_Phypa1_1_120016[RRM2][KOG4205]Aureococcus anophagefferens@jgi_Auran1_17068[RRM1][KOG4207]
Viridiplantae@NP_001046448[23][RRM1:100%***][put-sr:91%***][SR:35%**][KOG4207:13%*][.KOG0127:13%*][.KOG0110:9%]Phytophthora@jgi_Physo1_1_136528[2][RRM1:100%][put-sr:50%][KOG3208:50%]Chordata@ENSETEP00000001114[45][RRM1:100%***][put-sr:96%***][SRrp:82%***][KOG0111:29%**][.KOG0415:13%*]
Chlamydomonadales@jgi_Volca1_121229[2][RRM1:100%][put-sr:100%][KOG0415:50%]Cryptosporidium parvum_Iowa_II@XP_628282[2][RRM1:100%][put-sr:100%][KOG0111:50%][.KOG4207:50%]
Plasmodium falciparum_3D7@XP_001351591[RRM1]Plasmodium falciparum_3D7@XP_001347950[RRM1][KOG4207]
Murinae@ENSMUSP00000078984[3][RRM1:100%*][KOG4207:100%*]Dictyostelium discoideum_AX4@XP_628876[RRM1]
Strongylocentrotus purpuratus@XP_001178467[2][RRM1:100%][put-sr:100%]Strongylocentrotus purpuratus@XP_001180596[2][RRM1:100%][put-sr:100%]Eukaryota@ENSGALP00000022397[157][RRM1:100%*****][put-sr:75%****][SR:59%****][KOG0107:66%****]Endopterygota@CG5655-PA[5][RRM1:100%*][put-sr:100%*][KOG0107:80%*][.KOG0921:20%]
Bilateria@ENSLAFP00000012959[197][RRM3:93%*****][.RRM2:5%**][hnRNP:36%****][KOG0117:100%*****]Dictyostelium discoideum_AX4@XP_646584[RRM2][KOG0127]
Embryophyta@jgi_Phypa1_1_201182[6][RRM2:100%*][KOG0127:100%*]Chlamydomonas reinhardtii@jgi_Chlre3_186870[RRM2][KOG0127]
Ostreococcus@jgi_Ost9901_3_26255[2][RRM2:100%][KOG0127:100%]Drosophila melanogaster@CG4806-PA[RRM1][KOG0127]Aedes aegypti@AAEL008572-PA[RRM1][KOG0127]
Chordata@ENSOGAP00000005376[31][RRM2:90%***][.RRM3:6%][RBM:39%**][KOG0127:100%***]Embryophyta@IMGA_AC141435_12_2[17][RRM2:76%**][.RRM1:24%*][KOG4660:100%**]
Drosophila melanogaster@CG2050-PA[RRM3]Schizosaccharomyces pombe_972h-@NP_596114[RRM2][KOG0127]
Saccharomycetales@XP_459044[4][RRM2:100%*][KOG0127:100%*]Pezizomycotina@XP_962933[3][RRM2:100%*][KOG0127:100%*]
Yarrowia lipolytica@XP_499726[RRM2][KOG0127]Ustilago maydis_521@XP_757329[RRM2][KOG0145]
Eukaryota@IMGA_AC144483_30_2[123][RRM2:83%****][.RRM1:17%***][TIATIAR:58%****][.oligoU:6%*][KOG0148:99%****]Strongylocentrotus purpuratus@XP_001183631[2][RRM2:100%][KOG0148:100%]
Ciona intestinalis@ENSCINP00000004384[RRM2][KOG0148]Oryza sativa_japonica_cultivar-group@NP_001062811[RRM1][KOG1190]
Physcomitrella patens@jgi_Phypa1_1_137240[2][RRM1:100%][KOG3598:50%]Ricinus communis@30005_m001243[RRM1]Ricinus communis@29577_m000447[RRM1][KOG0123]
Arabidopsis thaliana@NP_181869[4][RRM1:100%*][FCAFPA:100%*][KOG0117:100%*]Volvox carteri@jgi_Volca1_88720[RRM3]
Chlamydomonas reinhardtii@jgi_Chlre3_148816[RRM2][KOG3598]Oryza sativa_japonica_cultivar-group@NP_001063671[RRM2][KOG0123]rosids@NP_001078046[5][RRM2:100%*][FCAFPA:80%*][KOG0117:80%*][.KOG0123:20%]
Physcomitrella patens@jgi_Phypa1_1_161310[RRM2][KOG3598]Gasterosteus aculeatus@ENSGACP00000006521[RRM1][KOG0548]
Danio rerio@ENSDARP00000075089[2][RRM1:100%][KOG0548:100%]Schizosaccharomyces pombe_972h-@NP_595389[RRM1][KOG4574]
Cryptococcus neoformans_var._neoformans_JEC21@XP_570411[RRM2][KOG4574]Yarrowia lipolytica@XP_500252[RRM1][KOG4574]
Neurospora crassa_OR74A@XP_962915[RRM1][KOG4574]Embryophyta@jgi_Phypa1_1_28366[17][RRM1:100%**][put-sr:76%**][KOG0127:29%*][.KOG0125:12%][.KOG4661:6%][.KOG0147:6%]Phytophthora@jgi_Physo1_1_137237[2][RRM1:100%][put-sr:100%][KOG0125:50%][.KOG0148:50%]
Plasmodium falciparum_3D7@XP_001347313[RRM1][KOG0127]Schizosaccharomyces pombe_972h-@NP_001018280[RRM1][KOG0145]
Chlamydomonas reinhardtii@jgi_Chlre3_152139[RRM1][KOG0117]Cryptococcus neoformans_var._neoformans_JEC21@XP_570425[RRM1][put-sr][KOG0145]
Pezizomycotina@XP_960722[3][RRM1:100%*][put-sr:33%][KOG0113:33%]Yarrowia lipolytica@XP_499712[RRM1][KOG0145]
Basidiomycota@XP_757472[3][RRM1:100%*][put-sr:33%][KOG0122:33%]Dictyostelium discoideum_AX4@XP_642304[RRM1][KOG0415]
Coelomata@AGAP006798-PA[81][RRM1:100%****][put-sr:99%****][KOG0122:26%***][.KOG0125:25%**][.KOG0147:14%**][.KOG0108:9%*]Caenorhabditis elegans@C18D11_4_1[2][RRM1:100%][put-sr:100%][KOG0921:100%]
Aedes aegypti@AAEL004293-PA[RRM1][put-sr]Drosophila melanogaster@CG10128-PC[6][RRM1:100%*][put-sr:100%*]
Eutheria@ENSMLUP00000005283[2][RRM1:100%][put-sr:100%]Spermophilus tridecemlineatus@ENSSTOP00000006011[RRM1][put-sr]
Magnoliophyta@NP_001062073[4][RRM1:100%*][KOG0110:75%*][.KOG0127:25%]Poaceae@8373_m000321_c0161G04[2][RRM1:100%][KOG4205:50%][.KOG4211:50%]
Trypanosoma brucei_TREU927@XP_829716[RRM1]Saccharomycetales@XP_455897[3][RRM1:100%*][KOG0123:67%]
Debaryomyces hansenii_CBS767@XP_460681[RRM3][KOG0128]Aspergillus fumigatus_Af293@XP_750045[RRM1]
Ustilago maydis_521@XP_758439[RRM3][KOG0123]Xenopus tropicalis@ENSXETP00000056096[RRM1][KOG0109]
Mammalia@ENSTBEP00000003150[16][RRM1:100%**][RBM:94%**][KOG0109:100%**]Clupeocephala@ENSGACP00000025151[11][RRM1:100%**][KOG0109:100%**]
Ciona intestinalis@ENSCINP00000023722[RRM1][KOG0109]Culicidae@AAEL001131-PA[2][RRM1:100%][KOG0113:100%]
Zea mays@11279_m000026_AZM5_6772[RRM1][put-sr][KOG0117]Oryza sativa_japonica_cultivar-group@NP_001067112[RRM2][put-sr][KOG0117]
Pezizomycotina@XP_961985[2][RRM1:100%][KOG0116:50%]
71 - RBM
17 - single-RRM
Zn-K SR proteins
43
50 - LARK
63 - hnRNP
23 - SRrp
22 - single-RRM SR proteins
27 - RNPS1
27 - RNPS126 - SR45
25
28
24
22 - single-RRM SR proteins
Fungal SpRnps1
Fig. S5
74
53
58
96
88
52
52
59
56
65
Magnoliophyta@NP 001060859[5][RRM1:100%*][cpRNP:40%][KOG0110:40%][ KOG0148:40%]Leishmania infantum_JPCM5@XP_001466659[RRM1][KOG0145]
Leishmania infantum_JPCM5@XP_001466665[RRM1][KOG0110]Trypanosoma brucei_TREU927@XP_843985[3][RRM1:100%*][put-sr:33%][KOG0110:100%*]
Leishmania infantum_JPCM5@XP_001466666[RRM1][KOG0145]Leishmania infantum_JPCM5@XP_001464836[RRM1][KOG0145]
Leishmania infantum_JPCM5@XP_001464835[2][RRM1:100%][KOG0145:100%]Ostreococcus@jgi_Ost9901_3_27365[2][RRM1:100%][KOG0123:50%]
Desulfuromonadales@NP_952377[4][RRM1:100%*][PROK:100%*][KOG0108:50%][.KOG0145:25%]Pelobacter carbinolicus_DSM_2380@YP_357907[RRM1][PROK][KOG0145]
Magnoliophyta@NP_001058927[3][RRM1:100%*][cpRNP:33%][KOG0131:67%]rosids@30054_m000821[3][RRM1:100%*][cpRNP:33%][KOG0127:100%*]
Oryza sativa_japonica_cultivar-group@NP_001053710[RRM1][KOG0127]Ostreococcus tauri@jgi_Ostta4_10328[RRM1][KOG2476]
Phytophthora sojae@jgi_Physo1_1_139998[RRM1]Aureococcus anophagefferens@jgi_Auran1_71372[2][RRM3:50%][.RRM2:50%][put-sr:100%][KOG1178:100%]
Phytophthora@jgi_Phyra1_1_77488[2][RRM1:100%][KOG4205:100%]Volvox carteri@jgi_Volca1_90315[RRM1]Ostreococcus tauri@jgi_Ostta4_34258[RRM2]
Caenorhabditis elegans@W02D3_11b[2][RRM1:100%][KOG4211:100%]Danio rerio@ENSDARP00000069459[RRM2][KOG4211]
Coelomata@ENSCINP00000003632[126][RRM2:70%****][.RRM1:30%***][hnRNP:37%***][.GRSRBP:15%**][KOG4211:100%****]Physcomitrella patens@jgi_Phypa1_1_162342[RRM3][KOG1365]
Oryzias latipes@ENSORLP00000025180[RRM2][put-sr][KOG4307]Volvox carteri@jgi_Volca1_117772[RRM1][KOG1365]
Plasmodium falciparum_3D7@XP_001347519[RRM1][KOG1365]Caenorhabditis elegans@Y73B6BL_33[RRM1][KOG4211]
Arabidopsis thaliana@NP_188725[RRM2][hnRNP][KOG1365]Thalassiosira pseudonana@jgi_Thaps3_5686[RRM2][KOG4211]
Ciona savignyi@ENSCSAVP00000001587[RRM5][KOG4307]Ustilago maydis_521@XP_761797[RRM1][put-sr][KOG3257]
Schizosaccharomyces pombe_972h-@NP_596114[RRM1][KOG0127]Basidiomycota@XP_568669[3][RRM1:100%*][KOG0127:100%*]
Euteleostomi@ENSOANP00000001262[28][RRM1:100%***][RBM:46%**][KOG0127:100%***]Sordariomycetes@XP_382687[2][RRM1:100%][KOG0127:100%]
Aspergillus fumigatus_Af293@XP_752199[RRM1][KOG0127]Magnoliophyta@10511_m000028_AZM5_5258[15][RRM1:100%**][cpRNP:33%*][KOG0127:53%**][.KOG0131:27%*][.KOG0145:13%][.KOG0108:7%]
Magnoliophyta@NP_001062760[4][RRM1:100%*][KOG0124:50%][.KOG0131:50%]Embryophyta@jgi_Phypa1_1_134646[11][RRM1:100%**][cpRNP:9%][KOG0123:45%*][.KOG0127:36%*][.KOG2029:9%]
Syntrophobacter fumaroxidans_MPOB@YP_844222[RRM1][PROK][KOG0108]Synechococcus@YP_473618[2][RRM1:100%][PROK:100%][KOG0108:100%]
Candida glabrata_CBS138@XP_445637[RRM1]Chordata@ENSETEP00000010530[36][RRM1:50%**][.RRM2:50%**][put-sr:100%***][SRrp:75%***][KOG4676:100%***]
Caenorhabditis elegans@R09B3_3[3][RRM1:100%*][KOG0108:100%*]Caenorhabditis elegans@B0035_12_2[2][RRM2:100%][KOG0128:100%]
Ostreococcus lucimarinus@jgi_Ost9901_3_28918[RRM1]Volvox carteri@jgi_Volca1_103724[RRM1][put-sr][KOG0591]
Arabidopsis thaliana@NP_180012[RRM1]Physcomitrella patens@jgi_Phypa1_1_167236[RRM1][KOG4209]
Magnoliophyta@IMGA_AC160842_25_1[6][RRM1:100%*][KOG3702:83%*][.KOG4209:17%]Ciona@ENSCSAVP00000010162[2][RRM1:100%][KOG4209:100%]Eukaryota@ENSCSAVP00000003369[89][RRM1:100%****][put-sr:17%**][PABP:26%***][KOG4209:100%****]
Dictyostelium discoideum_AX4@XP_642788[RRM1][KOG4209]Caenorhabditis elegans@T08B6_5[RRM1][KOG4209]Caenorhabditis elegans@EEED8_12[2][RRM1:100%][KOG4209:100%]
Strongylocentrotus purpuratus@XP_001180991[4][RRM1:100%*]Cyanidioschyzon merolae@gnl_CMER_CMO334C[RRM2][KOG0126]
Physcomitrella patens@jgi_Phypa1_1_188347[RRM2][KOG0123]Physcomitrella patens@jgi_Phypa1_1_167900[RRM2][KOG1015]
Magnoliophyta@29675_m000389[3][RRM2:100%*][KOG0123:67%][.KOG1015:33%]Arabidopsis thaliana@NP_188491[RRM2][nucleolin][KOG4210]
Tribolium castaneum@XP_972538[RRM1][KOG0128]Ciona intestinalis@ENSCINP00000019832[3][RRM1:100%*][KOG0128:100%*]
Culicidae@AAEL011961-PA[3][RRM1:100%*][KOG0128:100%*]Encephalitozoon cuniculi_GB-M1@NP_597167[RRM1][KOG0108]
Apocrita@XP_001602582[2][RRM1:100%][KOG0128:100%]Strongylocentrotus purpuratus@XP_781643[RRM1][KOG0128]
Ostreococcus@jgi_Ostta4_33150[2][RRM2:100%][KOG0108:50%]Euteleostomi@ENSSTOP00000002132[31][RRM1:100%***][SART3:68%***][KOG0128:100%***]
Ciona intestinalis@ENSCINP00000023563[RRM1][KOG0108]Strongylocentrotus purpuratus@XP_001198098[2][RRM1:100%][put-sr:100%][KOG0147:100%]
Ostreococcus@jgi_Ost9901_3_42846[2][RRM1:100%][put-sr:50%][KOG0147:100%]Volvox carteri@jgi_Volca1_84128[2][RRM1:100%][put-sr:50%][KOG0147:100%]
Plasmodium falciparum_3D7@XP_001349956[RRM1][KOG0147]Cryptosporidium parvum_Iowa_II@XP_628665[RRM1][KOG0147]
Phytophthora@jgi_Physo1_1_157186[2][RRM1:100%][KOG0147:100%]Dictyostelium discoideum_AX4@XP_638966[RRM1][KOG0147]
Eukaryota@ENSMLUP00000011758[47][RRM1:100%***][put-sr:91%***][UMH:64%***][.CAPER:15%*][KOG0147:100%***]Ascomycota@NP_594422[4][RRM1:100%*][put-sr:100%*][KOG0147:100%*]
Yarrowia lipolytica@XP_504318[RRM1][KOG0147]Eukaryota@ENSDARP00000064611[84][RRM1:100%****][KOG0108:99%****]
Chlamydomonadales@jgi_Volca1_48801[2][RRM1:100%][KOG0120:100%]Schizosaccharomyces pombe_972h-@NP_595396[RRM1][put-sr][KOG0120]Plasmodium falciparum_3D7@XP_001348830[RRM2][put-sr][KOG0120]
Pezizomycotina@XP_387225[3][RRM1:67%][.RRM2:33%][put-sr:100%*][KOG0120:100%*]Yarrowia lipolytica@XP_503754[RRM1][KOG0120]
Eukaryota@jgi_Volca1_82970[75][RRM2:91%****][.RRM1:9%*][put-sr:80%****][snRNP:53%***][KOG0120:100%****]Phaeodactylum tricornutum@jgi_Phatr2_11145[RRM2][KOG0120]
Euteleostomi@ENSXETP00000044031[49][RRM2:76%***][.RRM1:24%**][KOG0145:41%**][.KOG0123:14%*][.KOG0110:14%*]Ciona@ENSCSAVP00000018820[2][RRM2:100%][KOG0145:100%]
Volvox carteri@jgi_Volca1_107013[RRM3][KOG0117]Dictyostelium discoideum_AX4@XP_635793[RRM2][KOG0145]
Tribolium castaneum@XP_969008[RRM2][KOG0331]Plasmodium falciparum_3D7@XP_001352162[RRM1]
Plasmodium falciparum_3D7@XP_001351468[RRM1]Saccharomycetales@XP_462132[6][RRM1:100%*][KOG0533:100%*]
Mammalia@ENSETEP00000003776[19][RRM1:100%**][LA:95%**][KOG4213:100%**]Sordariomycetes@XP_956471[2][RRM1:100%][KOG0533:100%]
Schizosaccharomyces pombe_972h-@NP_595715[RRM1][KOG0533]Ustilago maydis_521@XP_760032[RRM1][KOG0533]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572037[RRM1][KOG0533]Cyanidioschyzon merolae@gnl_CMER_CMH135C[RRM1]
Phytophthora@jgi_Phyra1_1_97175[2][RRM1:100%][put-sr:50%][KOG0533:100%]Euteleostomi@ENSTBEP00000009485[3][RRM1:100%*][PDIP:33%][KOG0533:33%]Endopterygota@CG6961-PA[7][RRM1:100%*][KOG0533:29%]Chlamydomonadales@jgi_Volca1_90392[2][RRM1:100%][KOG0533:100%]
Eukaryota@GSTENP00007343001[69][RRM1:100%****][FCAFPA:10%*][KOG0533:99%****]Ostreococcus tauri@jgi_Ostta4_36431[RRM1][KOG0533]
Dictyostelium discoideum_AX4@XP_638266[RRM1][KOG0533]Pezizomycotina@XP_958422[3][RRM1:100%*][put-sr:33%][KOG0533:100%*]
Yarrowia lipolytica@XP_505140[RRM1][KOG0533]Ustilago maydis_521@XP_757147[RRM1][KOG0533]
Theileria parva_strain_Muguga@XP_764636[RRM1]Plasmodium falciparum_3D7@XP_966143[RRM1][KOG0533]
Cryptosporidium parvum_Iowa_II@XP_626158[RRM1][KOG0144]Chlamydomonadales@jgi_Volca1_120471[2][RRM1:100%][KOG0108:100%]
Ornithorhynchus anatinus@ENSOANP00000022523[3][RRM1:67%][.RRM2:33%][KOG2248:100%*]Chlamydomonadales@jgi_Volca1_107765[2][RRM1:100%][KOG0145:100%]Cyanidioschyzon merolae@gnl_CMER_CML202C[RRM1][put-sr]
Eukaryota@8925_m000027_AZM5_1178[67][RRM1:100%****][put-sr:84%****][SR:61%***][KOG4207:61%***][.KOG4368:24%**]
84 - La
s g e S p ote s
30 - hnRNP
PDIP
FCA FPA
64 - snRNP
75 - CAPER
UMH
73 - SART3
83 - PABP
85 - SRrp
70 - RBM
80 - hnRNP
Fig. S5
75
64
56
96
97
Aureococcus anophagefferens@jgi Auran1 9434[RRM1]Chlamydomonadales@jgi_Chlre3_184151[2][RRM1:100%][KOG0921:50%][.KOG0116:50%]
Coxiella_burnetii@YP_001424629[2][RRM1:100%][PROK:100%][KOG0108:100%]Aspergillus fumigatus_Af293@XP_747328[RRM1][KOG0110]
Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM1][KOG4212]Physcomitrella patens@jgi_Phypa1_1_96043[RRM1]
Volvox carteri@jgi_Volca1_103054[RRM2][KOG0055]Trypanosoma brucei_TREU927@XP_823301[RRM1][KOG0921]
Cryptosporidium parvum_Iowa_II@XP_628165[RRM2][KOG4212]Eukaryota@jgi_Volca1_109965[18][RRM1:78%**][.RRM2:22%*][put-sr:22%*][KOG4212:61%**][.KOG0123:39%*]
Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM2][KOG0123]Saccharomycetales@XP_446962[5][RRM1:100%*][put-sr:60%*][KOG0127:60%*][.KOG0123:40%]
Saccharomycetaceae@XP_462023[2][RRM1:100%][put-sr:100%][KOG0123:100%]Phytophthora@jgi_Phyra1_1_75500[2][RRM3:100%][KOG0123:100%]
Thalassiosira pseudonana@jgi_Thaps3_37126[RRM2][KOG0123]Phaeodactylum tricornutum@jgi_Phatr2_51303[RRM2][KOG4212]
Strongylocentrotus purpuratus@XP_786244[2][RRM3:100%][put-sr:100%][KOG4212:100%]Volvox carteri@jgi_Volca1_109965[RRM2][KOG4212]Chlamydomonadales@jgi_Volca1_78979[2][RRM1:100%][KOG3070:100%]
Phytophthora ramorum@jgi_Phyra1_1_84100[RRM2][KOG0105]Theileria parva_strain_Muguga@XP_766386[RRM2][put-sr][KOG0105]
Plasmodium falciparum_3D7@XP_001347501[RRM2][put-sr][KOG0105]Phytophthora@jgi_Physo1_1_136493[2][RRM2:100%][put-sr:100%][KOG0105:100%]Fungi/Metazoa_group@AGAP004592-PA[123][RRM2:81%****][.RRM1:18%***][put-sr:100%****][SR:60%****][KOG0105:50%****][.KOG0106:46%****]Bilateria@XP_967263[73][RRM2:78%****][.RRM1:22%**][put-sr:79%****][SR:75%****][KOG0105:100%****]
Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM2][KOG4212]Saccharomyces cerevisiae@YNL004W[RRM2][KOG0127]
Saccharomycetaceae@XP_453283[2][RRM1:50%][.RRM2:50%][KOG0123:50%][.KOG0127:50%]Candida glabrata_CBS138@XP_446962[RRM2][put-sr][KOG0127]
Saccharomycetales@XP_001386572[3][RRM2:67%][.RRM1:33%][put-sr:67%][KOG0123:67%][.KOG4212:33%]Cryptococcus neoformans_var._neoformans_JEC21@XP_572539[4][RRM2:100%*][KOG4212:100%*]
Basidiomycota@XP_758699[7][RRM1:71%*][.RRM2:29%][put-sr:14%][KOG4212:100%*]Saccharomycetales@XP_445179[2][RRM2:100%][put-sr:100%][KOG0123:100%]Cyanidioschyzon merolae@gnl_CMER_CMM078C[RRM2][KOG4212]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM2][put-sr][KOG0147]Pezizomycotina@XP_751108[2][RRM2:100%][put-sr:100%][KOG4212:100%]
Trypanosomatidae@XP_001465100[2][RRM1:100%][KOG4212:100%]Schizosaccharomyces pombe_972h-@NP_594207[RRM2][KOG4212]
Dikarya@XP_568231[5][RRM3:100%*][put-sr:80%*][KOG4212:80%*][.KOG0147:20%]Yarrowia lipolytica@XP_503927[RRM3][put-sr][KOG4212]
Saccharomycetales@XP_888678[3][RRM3:67%][.RRM2:33%][put-sr:67%][KOG0123:67%][.KOG4212:33%]Saccharomycetales@YNL004W[4][RRM3:100%*][put-sr:50%][KOG0123:50%][.KOG0127:50%]
Kluyveromyces lactis@XP_453283[RRM2][KOG0123]Coelomata@ENSMLUP00000006206[100][RRM2:88%****][.RRM1:12%**][put-sr:5%*][hnRNP:28%***][KOG4212:98%****]
Caenorhabditis elegans@C25A1_4_2[2][RRM2:100%][put-sr:100%][KOG4212:100%]Chordata@ENSOGAP00000002890[91][RRM3:80%****][.RRM2:13%**][.RRM1:7%*][hnRNP:37%***][KOG4212:100%****]
Chlamydomonadales@jgi_Chlre3_184854[2][RRM1:100%][KOG0055:50%]Bacillariophyta@jgi_Phatr2_7426[2][RRM1:100%]Endopterygota@CG9373-PA[4][RRM3:100%*][KOG4212:100%*]
Plasmodium falciparum_3D7@XP_001347353[RRM2][KOG4212]Theileria parva_strain_Muguga@XP_766728[RRM2][KOG0124]
Plasmodium falciparum_3D7@XP_001347332[RRM2][put-sr][KOG0105]Eukaryota@XP_391240[27][RRM2:67%**][.RRM1:33%**][cpRNP:19%*][KOG0127:48%**][.KOG0108:22%*][.KOG0131:15%*][.KOG0149:7%][.KOG0145:7%]
Volvox carteri@jgi_Volca1_36996[RRM1][KOG0116]Tribolium castaneum@XP_970765[RRM1][KOG0127]
Dictyostelium discoideum_AX4@XP_643856[3][RRM1:100%*][KOG0149:100%*]Chlamydomonadales@jgi_Volca1_103054[2][RRM3:50%][.RRM2:50%][KOG0055:50%]
Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM3][KOG0123]Aureococcus anophagefferens@jgi_Auran1_31715[RRM1][KOG0149]
Embryophyta@jgi_Phypa1_1_217831[15][RRM3:93%**][.RRM1:7%][KOG0117:100%**]Ustilago maydis_521@XP_756401[RRM1]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM5][KOG0123]Embryophyta@jgi_Phypa1_1_189930[7][RRM1:100%*][KOG0119:86%*][.KOG0307:14%]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM6][KOG0123]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM2][KOG0123]
Magnoliophyta@NP_189032[4][RRM1:100%*][put-sr:100%*][KOG0670:100%*]Ostreococcus tauri@jgi_Ostta4_24260[RRM1]
Caenorhabditis elegans@ZC404_8_2[2][RRM1:100%][KOG0125:100%]Bilateria@ENSORLP00000014121[125][RRM1:100%****][FOX:75%****][KOG0125:100%****]
Felis catus@ENSFCAP00000007638[RRM1][KOG0125]Saccharomycetales@XP_456900[7][RRM2:100%*][nucleolin:14%][KOG0148:57%*][.KOG0131:29%][.KOG4210:14%]
Pezizomycotina@XP_754840[2][RRM2:100%][KOG0127:50%][.KOG0148:50%]Schizosaccharomyces pombe_972h-@NP_593531[RRM2][nucleolin][KOG0147]
Ustilago maydis_521@XP_762340[RRM2][KOG0148]Cryptococcus neoformans_var._neoformans_JEC21@XP_566835[RRM2][KOG0148]
Ostreococcus lucimarinus@jgi_Ost9901_3_32831[RRM1]Aureococcus anophagefferens@jgi_Auran1_8214[RRM1]Phytophthora@jgi_Physo1_1_136329[2][RRM2:100%][KOG0123:100%]
Aspergillus fumigatus_Af293@XP_754657[RRM1]Eukaryota@jgi_Phypa1_1_37849[169][RRM1:100%*****][put-sr:5%**][GRSRBP:33%****][.hnRNP:18%***][.RBMY:15%***][KOG0108:23%***][.KOG0111:23%***][.KOG0149:18%***][.KOG0117:11%**][.KOG0116:9%**]
Magnoliophyta@NP_001059075[6][RRM1:100%*][put-sr:17%][GRSRBP:50%*][KOG0108:50%*][.KOG0148:33%][.KOG0111:17%]Arabidopsis thaliana@NP_173298[RRM1][GRSRBP][KOG0149]
Magnoliophyta@NP_181287[9][RRM1:100%**][oligoU:22%][KOG0148:56%*][.KOG0127:22%][.KOG0145:11%][.KOG0113:11%]Magnoliophyta@9946_m000021_AZM5_3995[2][RRM1:100%][KOG0111:50%][.KOG0113:50%]
Magnoliophyta@29930_m000611[5][RRM1:100%*][KOG0113:100%*]Ricinus communis@30055_m001598[RRM1][KOG0149]Arabidopsis thaliana@NP_565646[RRM1][KOG0149]
Magnoliophyta@NP_001052753[3][RRM1:100%*][oligoU:33%][KOG0108:33%][.KOG0149:33%][.KOG0127:33%]rosids@29154_m000213[5][RRM1:100%*][oligoU:40%][KOG0122:40%][.KOG0113:20%][.KOG0148:20%]
Medicago truncatula@IMGA_AC122162_7_2[RRM1][KOG0149]Legionella_pneumophila@YP_001249669[3][RRM1:100%*][PROK:100%*][put-sr:100%*][KOG0149:100%*]
eurosids_I@IMGA_CT963106_6_1[2][RRM1:100%][KOG0117:50%]Arabidopsis thaliana@NP_567594[RRM1][KOG0117]
Eukaryota@IMGA_AC183923_6_1[34][RRM3:74%***][.RRM1:15%*][.RRM2:12%*][put-sr:6%][KOG0110:100%***]Thalassiosira pseudonana@jgi_Thaps3_268689[RRM2][KOG0110]
Plasmodium falciparum_3D7@XP_966276[RRM2]Plasmodium falciparum_3D7@XP_001348607[RRM1]
Dikarya@NP_596771[2][RRM1:100%][KOG0108:50%]Aedes aegypti@AAEL006876-PA[RRM1][KOG2193]
Drosophila melanogaster@CG3312-PA[2][RRM1:100%][KOG0128:100%]Encephalitozoon cuniculi_GB-M1@NP_597181[RRM1][KOG0110]
Euteleostomi@ENSOCUP00000014007[29][RRM2:97%***][SART3:69%**][KOG0128:100%***]Ciona intestinalis@ENSCINP00000019833[3][RRM2:100%*][KOG0128:100%*]Apocrita@XP_001602582[2][RRM2:100%][KOG0128:100%]
Tribolium castaneum@XP_972538[RRM2][KOG0128]Culicidae@AAEL011963-PA[3][RRM2:100%*][KOG0128:100%*]
Strongylocentrotus purpuratus@XP_781643[RRM2][KOG0128]Phaeodactylum tricornutum@jgi_Phatr2_8270[RRM1][KOG4207]
Thalassiosira pseudonana@jgi_Thaps3_20266[RRM1][KOG4207]Bacillariophyta@jgi_Thaps3_20223[2][RRM1:100%][KOG0108:100%]
Cryptosporidium parvum_Iowa_II@XP_626081[RRM1][KOG0122]Aureococcus anophagefferens@jgi_Auran1_9375[2][RRM1:100%][KOG0122:100%]
Ostreococcus@jgi_Ost9901_3_12693[2][RRM2:100%][KOG0127:100%]Ostreococcus tauri@jgi_Ostta4_19468[RRM1][KOG0127]
Aureococcus anophagefferens@jgi_Auran1_9018[RRM1]Trypanosomatidae@XP_001465100[2][RRM2:100%][KOG4212:100%]
Dictyostelium discoideum_AX4@XP_629578[RRM1][KOG0122]Endopterygota@CG7903-PA[5][RRM1:100%*][KOG0109:80%*]
Tribolium castaneum@XP_971700[RRM1]Magnoliophyta@NP_001060859[5][RRM1:100%*][cpRNP:40%][KOG0110:40%][.KOG0148:40%]
39
32
3133 - p54nrb
PSP1
PSF
58 - GRSRBP
hnRNP
RBMYpart of 68 - FOX
30 - hnRNP
PDIP
FCA FPA
29 - dual-RRM
SR proteins
part of 63 - hnRNP
Fig. S5
76
82
88
52
66
56
61
67
70
80
73
58
65
52
56
53
63
73
Euteleostomi@ENSGACP00000016696[19][RRM3:79%**][ RRM4:11%][ RRM1:11%][RBM:58%**][KOG0127:100%**]Oryzias latipes@ENSORLP00000012079[RRM3][KOG0127]
Trypanosoma brucei_TREU927@XP_845376[RRM3][KOG0148]Cryptococcus neoformans_var._neoformans_JEC21@XP_569209[RRM2][KOG0144]
Endopterygota@CG10328-PA[9][RRM1:100%**][P54nrb:33%*][KOG0115:100%**]Deuterostomia@ENSDNOP00000008593[94][RRM1:100%****][P54nrb:28%***][.PSP1:21%**][.PSF:18%**][KOG0115:99%****]Caenorhabditis elegans@F25B5_7d[2][RRM1:100%][KOG0115:100%]
Neurospora crassa_OR74A@XP_965346[RRM1][KOG0110]Physcomitrella patens@jgi_Phypa1_1_93324[RRM1]
Apis mellifera@XP_623573[RRM1][KOG0113]Oryza sativa_japonica_cultivar-group@NP_001045556[RRM1][KOG0108]
Coelomata@ENSTBEP00000005385[105][RRM2:86%****][.RRM1:14%**][P54nrb:30%***][.PSP1:24%***][.PSF:21%***][KOG0115:100%****]Volvox carteri@jgi_Volca1_116517[RRM2][KOG1984]Dictyostelium discoideum_AX4@XP_646802[RRM2][KOG0145]
Dictyostelium discoideum_AX4@XP_641568[RRM2][KOG3598]Saccharomycetales@XP_445844[3][RRM2:100%*][KOG0123:33%]
Kluyveromyces lactis@XP_455897[RRM2][KOG0123]Pichia stipitis_CBS_6054@XP_001384462[RRM2]
Debaryomyces hansenii_CBS767@XP_460517[RRM2][KOG0117]Phaeodactylum tricornutum@jgi_Phatr2_49387[RRM1]
Dictyostelium discoideum_AX4@XP_645848[RRM1][put-sr]Dictyostelium discoideum_AX4@XP_638672[RRM1][put-sr][KOG0147]Dictyostelium discoideum_AX4@XP_629950[RRM1][KOG0128]
Dictyostelium discoideum_AX4@XP_643007[RRM1]Dictyostelium discoideum_AX4@XP_638262[RRM1][put-sr][KOG0670]
Eukaryota@ENSFCAP00000006163[84][RRM2:88%****][.RRM1:12%**][put-sr:86%****][UMH:39%***][.CAPER:8%*][KOG0147:100%****]Bilateria@Y47G6A_20a[64][RRM1:100%****][UMH:73%***][KOG0124:100%****]
Ostreococcus tauri@jgi_Ostta4_31925[RRM1][KOG0117]Phytophthora ramorum@jgi_Phyra1_1_81440[2][RRM1:100%][KOG0124:100%]
Neurospora crassa_OR74A@XP_964541[RRM1]Aspergillus fumigatus_Af293@XP_748929[RRM1]
Leishmania infantum_JPCM5@XP_001464648[RRM1][KOG0113]Viridiplantae@jgi_Chlre3_99594[25][RRM1:100%***][KOG0123:8%]
Ostreococcus@jgi_Ost9901_3_7913[3][RRM1:100%*][KOG0131:33%]Trypanosoma brucei_TREU927@XP_829593[RRM1]
Plasmodium falciparum_3D7@XP_966051[RRM1]Encephalitozoon cuniculi_GB-M1@XP_965888[RRM1][KOG4209]
Saccharomyces cerevisiae@YMR268C[RRM1][KOG0128]Pichia stipitis_CBS_6054@XP_001384763[RRM1][KOG0123]
Neurospora crassa_OR74A@XP_958552[RRM1][KOG0128]Neurospora crassa_OR74A@XP_960450[RRM1]
Magnoliophyta@15974_m000013_AZM5_17589[3][RRM2:67%][.RRM1:33%]Plasmodium falciparum_3D7@XP_966051[RRM2]
Cryptosporidium parvum_Iowa_II@XP_627780[RRM2][KOG0131]Eukaryota@jgi_Physo1_1_108557[316][RRM2:91%*****][.RRM1:9%***][PABP:46%****][KOG0123:79%*****][.KOG0131:21%****]
Saccharomycetaceae@XP_001385635[2][RRM2:100%][KOG0131:100%]Yarrowia lipolytica@XP_503979[RRM2][KOG0131]
Physcomitrella patens@jgi_Phypa1_1_176266[RRM1][KOG1924]Dictyostelium discoideum_AX4@XP_001134510[RRM4][KOG0123]
Dictyostelium discoideum_AX4@XP_645848[RRM2][put-sr]Cryptococcus neoformans_var._neoformans_JEC21@XP_566572[RRM1][KOG0111]
Coelomata@ENSORLP00000008206[18][RRM1:100%**][snRNP:83%**][KOG4206:100%**]Sordariomycetes@XP_962704[2][RRM1:100%][put-sr:50%][KOG4206:100%]
Pichia stipitis_CBS_6054@XP_001382592[RRM1][KOG4206]Tetrapoda@ENSXETP00000004736[17][RRM2:59%**][.RRM1:41%*][PTBP:94%**][KOG1190:100%**]
Dictyostelium discoideum_AX4@XP_646268[RRM1][KOG0146]Dictyostelium discoideum_AX4@XP_629218[RRM1][KOG0151]
Ciona intestinalis@ENSCINP00000027768[RRM1][KOG0548]Dictyostelium discoideum_AX4@XP_629218[RRM2][KOG0151]
Euteleostomi@ENSMODP00000018834[25][RRM1:100%***][put-sr:64%**][KOG0147:48%**][.KOG0132:12%*]Tribolium castaneum@XP_971953[RRM1]Strongylocentrotus purpuratus@XP_001185731[2][RRM1:100%]
Ciona@ENSCSAVP00000015853[4][RRM2:100%*][KOG0145:100%*]Dictyostelium discoideum_AX4@XP_629639[RRM2][KOG0145]
Plasmodium falciparum_3D7@XP_001348072[RRM1][KOG0144]Schizosaccharomyces pombe_972h-@NP_593427[RRM2][KOG0123]
Schizosaccharomyces pombe_972h-@NP_001018242[RRM3][KOG0123]Saccharomycetaceae@XP_451236[2][RRM1:100%][KOG0144:100%]
Saccharomyces cerevisiae@YGR250C[RRM1][KOG0108]Pichia stipitis_CBS_6054@XP_001386002[RRM2][KOG0148]
Debaryomyces hansenii_CBS767@XP_461354[RRM2][KOG0148]Yarrowia lipolytica@XP_501542[RRM2][KOG0131]
Cryptococcus neoformans_var._neoformans_JEC21@XP_571861[RRM1][KOG0226]Eukaryota@XP_964958[72][RRM1:100%****][KOG0226:100%****]
Nasonia vitripennis@XP_001603091[RRM1][KOG0226]Dictyostelium discoideum_AX4@XP_635179[RRM1][KOG0148]
Aureococcus anophagefferens@jgi_Auran1_28594[RRM2][KOG0148]Endopterygota@AAEL011988-PA[5][RRM2:100%*][KOG0144:80%*][.KOG0145:20%]
Dictyostelium discoideum_AX4@XP_641688[RRM1][KOG0117]Ustilago maydis_521@XP_761797[RRM2][put-sr][KOG3257]
Ciona intestinalis@ENSCINP00000008726[RRM1][put-sr][KOG2193]Thalassiosira pseudonana@jgi_Thaps3_18991[RRM1][KOG0226]
Phaeodactylum tricornutum@jgi_Phatr2_13402[RRM1][KOG0226]Saccharomycetales@XP_455748[4][RRM2:100%*][KOG0148:75%*][.KOG0145:25%]
Eukaryota@ENSMUSP00000030730[72][RRM2:85%****][.RRM1:15%**][oligoU:10%*][KOG0148:58%***][.KOG0123:25%**][.KOG0131:14%**]Saccharomycetales@XP_460477[6][RRM1:67%*][.RRM2:33%][KOG0148:67%*][.KOG3598:17%][.KOG0145:17%]
Ciona@ENSCSAVP00000020066[4][RRM1:50%][.RRM2:50%][KOG0131:50%]cellular_organisms@YP_001113853[137][RRM1:100%****][PROK:99%****][KOG0108:58%****][.KOG0116:14%**][.KOG0921:7%**][.KOG0149:7%**][.KOG0111:6%**]
Magnoliophyta@IMGA_AC119413_25_2[4][RRM2:100%*][cpRNP:25%][KOG0127:100%*]Carboxydothermus hydrogenoformans_Z-2901@YP_359251[RRM1][PROK][KOG0108]
rosids@NP_171616[3][RRM2:100%*][cpRNP:67%][KOG0148:67%][.KOG0110:33%]Oryza sativa_japonica_cultivar-group@NP_001060859[RRM2][KOG0110]
Schizosaccharomyces pombe_972h-@NP_596721[RRM3][KOG0128]Aspergillus fumigatus_Af293@XP_749317[RRM3][KOG0128]
Physcomitrella patens@jgi_Phypa1_1_167900[3][RRM1:100%*][KOG0123:33%][.KOG4210:33%][.KOG1015:33%]Cyanidioschyzon merolae@gnl_CMER_CMT598C[RRM1][KOG0148]
Embryophyta@jgi_Phypa1_1_161416[4][RRM1:100%*][put-sr:75%*][KOG0154:75%*][.KOG0147:25%]Dictyostelium discoideum_AX4@XP_646990[RRM1][put-sr][KOG0147]
Magnoliophyta@NP_001048500[5][RRM2:100%*][cpRNP:20%][KOG0123:100%*]Strongylocentrotus purpuratus@XP_792521[4][RRM1:100%*][put-sr:100%*][KOG0109:100%*]
Diptera@AAEL008317-PA[3][RRM1:100%*][KOG0149:100%*]Diptera@AAEL006645-PA[2][RRM1:100%][KOG0149:100%]
Poaceae@19213_m000022_AZM5_85721[2][RRM1:50%][.RRM2:50%][KOG0127:50%]Ricinus communis@29908_m006094[RRM2][KOG0110]
Arabidopsis thaliana@NP_192643[2][RRM2:100%][KOG0110:100%]Chlamydomonadales@jgi_Volca1_54847[2][RRM1:100%][KOG0108:100%]
Aureococcus anophagefferens@jgi_Auran1_64341[RRM2][KOG0108]stramenopiles@jgi_Auran1_17857[4][RRM1:50%][.RRM2:50%][KOG0108:50%][.KOG4205:50%]
Ostreococcus lucimarinus@jgi_Ost9901_3_92667[RRM1]Ostreococcus tauri@jgi_Ostta4_32569[RRM2]
Phytophthora@jgi_Physo1_1_141766[2][RRM2:100%][KOG0148:100%]Embryophyta@28180_m000395[6][RRM2:100%*][KOG0124:50%*][.KOG4205:33%][.KOG4211:17%]
Magnoliophyta@NP_001053909[5][RRM1:100%*][nucleolin:40%][KOG0123:40%][.KOG4210:40%][.KOG1015:20%]Neurospora crassa_OR74A@XP_963862[RRM1][KOG0127]
Saccharomycetales@XP_456900[6][RRM1:100%*][nucleolin:17%][KOG0148:50%*][.KOG0131:33%][.KOG4210:17%]Schizosaccharomyces pombe_972h-@NP_593531[RRM1][nucleolin][KOG0147]
Aspergillus fumigatus_Af293@XP_754840[RRM1][KOG0148]Basidiomycota@XP_566835[2][RRM1:100%][KOG0148:100%]
Yarrowia lipolytica@XP_505375[RRM1][KOG0148]Aureococcus anophagefferens@jgi_Auran1_9434[RRM1]
88 - prokaryotic RRMs
77 - TIA TIAR
OligoU
40 - snRNP
4 - PABP
p54nrb
PSP1
PSF
67 - UMH
33 - p54nrb
PSP1
PSF
part of 4
- PABP
p54nrb
PSP1
Fig. S5
77
50
52
74
75
70
51
63
59
50
60
69
57
66
83
82
52
76
52 50
70
88
Strongylocentrotus purpuratus@XP 001185821[2][RRM1:100%][KOG0670:100%]Trypanosomatidae@XP_827358[2][RRM2:100%][KOG0123:100%]Eukaryota@ENSETEP00000015606[204][RRM3:85%*****][.RRM2:11%***][PABP:66%****][KOG0123:100%*****]
Echinops telfairi@ENSETEP00000008100[RRM3][PABP][KOG0123]Aureococcus anophagefferens@jgi_Auran1_9354[RRM1]Dikarya@XP_960425[12][RRM3:100%**][PABP:17%][KOG0123:100%**]
Phytophthora@jgi_Physo1_1_108322[2][RRM3:100%][KOG0123:100%]Thalassiosira pseudonana@jgi_Thaps3_13224[RRM3][KOG0123]
Phaeodactylum tricornutum@jgi_Phatr2_23959[RRM3][KOG0123]Yarrowia lipolytica@XP_501289[RRM3][KOG0123]
Embryophyta@jgi_Phypa1_1_140180[4][RRM3:100%*][KOG0117:100%*]Strongylocentrotus purpuratus@XP_793277[2][RRM3:100%][KOG0117:100%]
Embryophyta@NP_188026[13][RRM1:100%**][oligoU:38%*][KOG0148:100%**]rosids@NP_001030849[6][RRM1:100%*][KOG0117:100%*]
Oryza sativa_japonica_cultivar-group@NP_001066102[RRM1][KOG0117]Dictyostelium discoideum_AX4@XP_644288[RRM1][KOG3598]
Aedes aegypti@AAEL010888-PA[RRM2]Phaeodactylum tricornutum@jgi_Phatr2_10122[RRM1][KOG0153]
Arabidopsis thaliana@NP_179762[RRM1][oligoU]Physcomitrella patens@jgi_Phypa1_1_170658[RRM1]Encephalitozoon cuniculi_GB-M1@NP_584552[RRM3][KOG0123]
Encephalitozoon cuniculi_GB-M1@NP_586099[RRM2][KOG0131]Oryza sativa_japonica_cultivar-group@NP_001054954[2][RRM1:100%][KOG0108:100%]
Chlamydomonadales@jgi_Volca1_107658[2][RRM1:100%][KOG4205:50%][.KOG0474:50%]Ciona intestinalis@ENSCINP00000024280[RRM1][KOG0113]
rosids@NP_568388[3][RRM1:100%*][KOG0125:33%][.KOG0148:33%]Physcomitrella patens@jgi_Phypa1_1_151460[4][RRM1:100%*][KOG0108:75%*][.KOG0149:25%]
Ostreococcus lucimarinus@jgi_Ost9901_3_7602[RRM1][KOG0145]Trypanosomatidae@XP_847111[2][RRM1:100%]
Leishmania infantum_JPCM5@XP_001465764[RRM1]Phytophthora@jgi_Phyra1_1_84416[2][RRM1:100%][KOG0148:100%]
Trypanosoma brucei_TREU927@XP_951655[RRM3][put-sr][KOG0109]Physcomitrella patens@jgi_Phypa1_1_12664[RRM1]
rosids@30155_m001644[2][RRM1:100%][KOG0116:50%]Aureococcus anophagefferens@jgi_Auran1_66158[RRM1][put-sr][KOG0149]
Phytophthora@jgi_Phyra1_1_50314[2][RRM3:100%][KOG0148:100%]Aureococcus anophagefferens@jgi_Auran1_28594[RRM3][KOG0148]
Eukaryota@YHR086W[51][RRM3:76%***][.RRM2:20%**][oligoU:10%*][KOG0148:90%***]Schizosaccharomyces pombe_972h-@NP_594243[RRM3][KOG0148]
Trypanosoma brucei_TREU927@XP_844190[RRM1][KOG0144]Dictyostelium discoideum_AX4@XP_645138[RRM1]
Ricinus communis@28452_m000049[RRM1][KOG1457]Medicago truncatula@IMGA_CU012061_4_1[RRM1]
Euteleostomi@ENSDARP00000069729[82][RRM1:100%****][KOG1995:77%****][.KOG0921:16%**][.KOG2044:5%*]Endopterygota@XP_624681[6][RRM1:100%*][put-sr:17%][KOG0921:67%*][.KOG1548:33%]
Strongylocentrotus purpuratus@XP_001196853[2][RRM1:100%][KOG1995:100%]Arabidopsis thaliana@NP_564565[RRM1][put-sr][KOG1995]
Apis mellifera@XP_393878[RRM1][put-sr][KOG2193]Theileria parva_strain_Muguga@XP_766466[RRM3][KOG0123]
Plasmodium falciparum_3D7@XP_001350640[RRM3][KOG0123]Clupeocephala@ENSORLP00000009616[3][RRM1:100%*][KOG0548:100%*]
Strongylocentrotus purpuratus@XP_001188888[2][RRM1:100%][KOG0548:100%]Aedes aegypti@AAEL010890-PA[RRM1][put-sr][KOG0132]
Eutheria@ENSETEP00000000464[10][RRM1:100%**][put-sr:100%**][KOG0132:100%**]Endopterygota@CG4266-PA[5][RRM1:100%*][put-sr:100%*][KOG0132:100%*]
Saccharomyces cerevisiae@YMR268C[RRM2][KOG0128]Debaryomyces hansenii_CBS767@XP_460681[RRM2][KOG0128]
Pezizomycotina@XP_749317[2][RRM2:100%][KOG0128:100%]Schizosaccharomyces pombe_972h-@NP_596721[RRM2][KOG0128]
Phytophthora@jgi_Physo1_1_140019[2][RRM1:100%][KOG0116:100%]Cryptosporidium parvum_Iowa_II@XP_626331[RRM1][KOG0146]
Thalassiosira pseudonana@jgi_Thaps3_2206[RRM1]Encephalitozoon cuniculi_GB-M1@NP_584580[RRM1][KOG0114]
Debaryomyces hansenii_CBS767@XP_458197[RRM1][KOG0114]Ciona@ENSCSAVP00000005375[4][RRM2:75%*][.RRM1:25%][KOG0116:75%*][.KOG2141:25%]
Saccharomycetales@XP_454821[4][RRM1:100%*][KOG3598:50%][.KOG1984:25%]Coelomata@ENSMMUP00000010529[37][RRM3:54%**][.RRM2:41%**][.RRM1:5%][put-sr:92%***][KOG0112:84%***][.KOG3598:8%*]Strongylocentrotus purpuratus@XP_001184502[2][RRM2:100%][put-sr:100%][KOG1144:100%]
Plasmodium falciparum_3D7@XP_001347332[RRM1][put-sr][KOG0105]Saccharomyces cerevisiae@YLL046C[RRM1]
Plasmodium falciparum_3D7@XP_001347876[RRM1][KOG0105]Theileria parva_strain_Muguga@XP_764943[RRM1][KOG4206]
Saccharomycetales@XP_454345[4][RRM1:100%*][KOG0148:75%*][.KOG0123:25%]Bilateria@ENSSARP00000011721[82][RRM1:100%****][TIATIAR:80%****][KOG0148:100%****]
Saccharomycetaceae@XP_001383142[2][RRM1:100%][put-sr:100%][KOG0148:100%]Yarrowia lipolytica@XP_501542[RRM1][KOG0131]Sordariomycetes@XP_385593[2][RRM1:100%][KOG0148:100%]Cryptococcus neoformans_var._neoformans_JEC21@XP_570577[RRM1][KOG0148]
Trypanosoma brucei_TREU927@XP_845742[RRM1][KOG0126]Phytophthora ramorum@jgi_Phyra1_1_77702[RRM1][KOG0154]
Theileria parva_strain_Muguga@XP_766553[RRM1][KOG4208]Cyanidioschyzon merolae@gnl_CMER_CMI122C[RRM1][KOG4208]
Thalassiosira pseudonana@jgi_Thaps3_18198[RRM1][KOG4208]Phaeodactylum tricornutum@jgi_Phatr2_45356[RRM1][KOG4208]
Eukaryota@CG6937-PA[73][RRM1:100%****][put-sr:5%*][KOG4208:99%****]Caenorhabditis elegans@T04A8_6[RRM1][KOG4208]
Dictyostelium discoideum_AX4@XP_643547[RRM1]Anopheles gambiae@AGAP006090-PA[RRM1]
Euteleostomi@GSTENP00013801001[29][RRM1:100%***][LA:59%**][KOG1855:100%***]Euteleostomi@ENSORLP00000006283[2][RRM1:100%][LA:50%][KOG1855:100%]
Apocrita@XP_001600355[2][RRM1:100%][KOG1855:100%]Tribolium castaneum@XP_974730[RRM1][KOG1855]Embryophyta@29727_m000492[13][RRM3:92%**][.RRM2:8%][oligoU:46%*][KOG0148:100%**]Dikarya@XP_570577[4][RRM3:100%*][KOG0148:100%*]
Bacillariophyta@jgi_Phatr2_20857[2][RRM2:100%][put-sr:100%][KOG0147:100%]Aedes aegypti@AAEL006197-PA[RRM1][KOG0108]
Percomorpha@ENSGACP00000007987[5][RRM1:100%*][IGF2BP:80%*][KOG2193:100%*]Dictyostelium discoideum_AX4@XP_641693[RRM1][KOG0122]
Caenorhabditis elegans@Y37D8A_21_1[2][RRM1:100%][KOG4454:100%]Deuterostomia@ENSXETP00000012868[47][RRM1:100%***][KOG4454:60%***][.KOG0131:40%**]
Magnoliophyta@NP_001055607[4][RRM1:100%*][put-sr:25%][KOG0131:100%*]Endopterygota@AGAP002256-PA[4][RRM1:100%*][KOG4454:75%*][.KOG0131:25%]Drosophila melanogaster@CG11454-PA[RRM1][KOG4454]
Ashbya gossypii_ATCC_10895@NP_982888[RRM1][KOG0131]Saccharomyces cerevisiae@YOR319W[RRM1][KOG0131]Candida glabrata_CBS138@XP_447678[RRM1][KOG0131]Saccharomycetaceae@XP_001385635[2][RRM1:100%][KOG0131:100%]
Dictyostelium discoideum_AX4@XP_647248[RRM1][KOG0131]Eukaryota@NP_001064759[59][RRM1:100%****][snRNP:8%*][KOG0131:100%****]
Plasmodium falciparum_3D7@XP_001348367[RRM1][KOG0131]Cryptosporidium parvum_Iowa_II@XP_627780[RRM1][KOG0131]
Coxiella_burnetii@YP_001424503[2][RRM1:100%][PROK:100%][KOG0113:100%]Cryptosporidium parvum_Iowa_II@XP_627799[RRM2][KOG0110]
Thalassiosira pseudonana@jgi_Thaps3_263845[RRM1][KOG0108]Drosophila melanogaster@CG4806-PA[RRM2][KOG0127]
Endopterygota@XP_001605703[3][RRM2:67%][.RRM3:33%][KOG0127:100%*]Aedes aegypti@AAEL008572-PA[RRM2][KOG0127]
Caenorhabditis elegans@R05H10_2[RRM2][KOG0127]Ciona intestinalis@ENSCINP00000018774[2][RRM3:100%][KOG0127:100%]
Euteleostomi@ENSGACP00000016696[19][RRM3:79%**][.RRM4:11%][.RRM1:11%][RBM:58%**][KOG0127:100%**]
72 - RBMPSF UMH
46
47
49
48 - IGF2BP
part of 79 - TIA TIAR
OligoU81 - La
82
76 - TIA TIAR
OligoU
54
78 - OligoU
Fig. S5
78
67
77
72
73 98
100
86
80
70
73
83
85
73
70
69
Ostreococcus tauri@jgi Ostta4 31833[RRM2][KOG0148]Saccharomyces cerevisiae@YMR268C[RRM3][KOG0128]
Dictyostelium discoideum_AX4@XP_644288[RRM2][KOG3598]Dictyostelium discoideum_AX4@XP_635179[RRM2][KOG0148]
Trypanosomatidae@XP_829274[2][RRM1:100%][KOG0145:50%]Leishmania infantum_JPCM5@XP_001463468[RRM1]
Trypanosoma brucei_TREU927@XP_829272[RRM1][KOG0145]Leishmania infantum_JPCM5@XP_001463465[RRM1][KOG0122]
Encephalitozoon cuniculi_GB-M1@NP_586226[RRM2][put-sr][KOG0123]Ashbya gossypii_ATCC_10895@NP_984845[RRM2][KOG0123]
Cyanidioschyzon merolae@gnl_CMER_CMG025C[RRM1][KOG1080]Leishmania infantum_JPCM5@XP_001466041[RRM2][KOG0123]
rosids@30146_m003481[2][RRM2:100%][PABP:50%][KOG0123:100%]rosids@30078_m002213[3][RRM2:100%*][PABP:33%][KOG0123:100%*]
Arabidopsis thaliana@NP_174676[RRM1][PABP][KOG0123]Theileria parva_strain_Muguga@XP_765501[RRM2][KOG0127]
Oryza sativa_japonica_cultivar-group@NP_001049727[RRM2][KOG0123]Dictyostelium discoideum_AX4@XP_638262[RRM2][put-sr][KOG0670]
Bilateria@ENSCSAVP00000007991[62][RRM2:95%****][.RRM1:5%*][UMH:74%***][KOG0124:100%****]Phytophthora@jgi_Phyra1_1_84640[3][RRM2:67%][.RRM1:33%][KOG0124:67%][.KOG0120:33%]
Cryptosporidium parvum_Iowa_II@XP_628096[RRM2][put-sr][KOG0124]Leishmania infantum_JPCM5@XP_001466413[RRM3][put-sr][KOG0147]Dictyostelium discoideum_AX4@XP_638966[RRM2][KOG0147]Ostreococcus@jgi_Ost9901_3_41266[2][RRM1:100%][KOG0153:100%]
Embryophyta@jgi_Phypa1_1_185655[7][RRM1:100%*][KOG0153:100%*]Ciona@ENSCSAVP00000015574[2][RRM1:100%][KOG0153:100%]
Encephalitozoon cuniculi_GB-M1@NP_585779[RRM1]Coelomata@XP_975014[28][RRM1:100%***][RBM:86%***][KOG0153:100%***]
Caenorhabditis elegans@T11G6_8_1[2][RRM1:100%][KOG0153:100%]Encephalitozoon cuniculi_GB-M1@NP_584552[RRM1][KOG0123]
Plasmodium falciparum_3D7@XP_001349948[RRM1][KOG0111]Eukaryota@ENSGALP00000021793[59][RRM1:100%****][cyclophilin:59%***][KOG0111:98%****]Eutheria@ENSEEUP00000009324[3][RRM1:100%*][cyclophilin:100%*][KOG0111:100%*]Otolemur garnettii@ENSOGAP00000003225[RRM1][KOG0111]
Thalassiosira pseudonana@jgi_Thaps3_31121[RRM1][KOG0111]Phaeodactylum tricornutum@jgi_Phatr2_11308[RRM1][KOG0111]
Pezizomycotina@XP_755630[3][RRM1:100%*][KOG0111:100%*]Phytophthora ramorum@jgi_Phyra1_1_76171[2][RRM1:100%][KOG0111:100%]
Caenorhabditis elegans@Y55F3AM_3c_1[3][RRM2:100%*][put-sr:33%][UMH:100%*][KOG0147:100%*]Schizosaccharomyces pombe_972h-@NP_595190[RRM1][KOG0111]
Cryptococcus neoformans_var._neoformans_JEC21@XP_571060[RRM2][KOG0147]Ustilago maydis_521@XP_756311[RRM2][put-sr][KOG0147]
Cryptosporidium parvum_Iowa_II@XP_628096[RRM1][put-sr][KOG0124]Ascomycota@XP_385341[4][RRM2:100%*][put-sr:100%*][KOG0147:100%*]
Yarrowia lipolytica@XP_504318[RRM2][KOG0147]Phytophthora@jgi_Phyra1_1_94266[2][RRM2:100%][KOG0147:100%]
Plasmodium falciparum_3D7@XP_001349956[RRM2][KOG0147]Leishmania infantum_JPCM5@XP_001467067[2][RRM1:100%][KOG0144:100%]
Bilateria@CG3151-PE[218][RRM2:92%*****][.RRM1:7%**][ELAV:84%*****][KOG0145:100%*****]Ustilago maydis_521@XP_759141[RRM2][KOG0145]
Gammaproteobacteria@YP_001083500[11][RRM1:100%**][PROK:100%**][KOG0145:27%*][.KOG0108:18%][.KOG0144:9%][.KOG0122:9%]Vibrio fischeri_ES114@YP_206444[RRM1][PROK][KOG0145]
Phytophthora@jgi_Phyra1_1_74707[2][RRM3:100%][KOG0110:100%]Volvox carteri@jgi_Volca1_63158[RRM2][KOG0110]Schizosaccharomyces pombe_972h-@NP_594609[RRM1][KOG4660]
Saccharomycetales@NP_984279[4][RRM1:100%*][KOG0921:75%*][.KOG0106:25%]Encephalitozoon cuniculi_GB-M1@NP_586226[RRM3][put-sr][KOG0123]
Ricinus communis@30146_m003481[RRM3][KOG0123]Euteleostomi@ENSGALP00000012472[36][RRM4:89%***][.RRM2:8%*][nucleolin:56%**][KOG0123:100%***]
Trypanosomatidae@XP_843886[2][RRM1:100%][KOG0145:100%]Trypanosomatidae@XP_828145[5][RRM1:100%*][KOG0145:100%*]
Trypanosoma brucei_TREU927@XP_845996[RRM1][KOG0122]Trypanosomatidae@XP_847495[2][RRM1:100%][KOG0110:50%][.KOG0127:50%]
Dictyostelium discoideum_AX4@XP_644081[RRM2][KOG0123]Dictyostelium discoideum_AX4@XP_644081[RRM3][KOG0123]
Aconoidasida@XP_001349292[3][RRM2:100%*][KOG0146:67%][.KOG0144:33%]Plasmodium falciparum_3D7@XP_001350320[RRM3][KOG0123]
Cryptosporidium parvum_Iowa_II@XP_001388078[RRM3][put-sr][KOG0144]Eukaryota@ENSOANP00000006980[251][RRM3:67%*****][.RRM2:24%****][.RRM1:10%***][Bruno:50%****][KOG0144:55%****][.KOG0146:45%****]
Theileria parva_strain_Muguga@XP_766017[RRM3][KOG0144]Plasmodium falciparum_3D7@XP_001350320[RRM2][KOG0123]
Bilateria@ENSORLP00000004891[130][RRM1:100%****][RBMS:72%****][KOG0145:99%****]Ciona@ENSCINP00000023191[4][RRM3:75%*][.RRM1:25%][KOG0145:100%*]
Dictyostelium discoideum_AX4@XP_635793[RRM3][KOG0145]Coelomata@ENSTBEP00000015452[229][RRM3:88%*****][.RRM2:9%**][ELAV:82%*****][KOG0145:100%*****]
Caenorhabditis elegans@F35H8_5[RRM3][KOG0145]Theria@ENSMODP00000002817[2][RRM1:100%]
Yarrowia lipolytica@XP_505724[RRM1][KOG4198]Trypanosomatidae@XP_001469326[2][RRM4:100%][KOG0123:100%]
Trypanosomatidae@XP_001469222[2][RRM4:100%][KOG0123:100%]Ustilago maydis_521@XP_759458[RRM2][KOG0123]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569319[RRM1][KOG0123]Pezizomycotina@XP_750167[2][RRM4:100%][KOG0123:100%]
Eukaryota@ENSDNOP00000002400[249][RRM4:82%*****][.RRM3:11%***][.RRM2:6%**][PABP:54%****][KOG0123:100%*****]Leishmania infantum_JPCM5@XP_001466041[RRM4][KOG0123]
Arabidopsis thaliana@NP_188259[RRM4][PABP][KOG0123]Drosophila melanogaster@CG4612-PA[RRM2][KOG0123]
Cryptosporidium parvum_Iowa_II@XP_001388334[RRM3][KOG0123]Yarrowia lipolytica@XP_500351[RRM3][KOG0123]Aedes aegypti@AAEL007013-PA[RRM1][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM3][KOG0123]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM1][KOG0123]
Ustilago maydis_521@XP_757329[RRM1][KOG0145]Volvox carteri@jgi_Volca1_84128[RRM2][KOG0147]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM4][KOG0123]
Volvox carteri@jgi_Volca1_106063[RRM2]Dictyostelium discoideum_AX4@XP_636266[RRM3][KOG3598]
Dictyostelium discoideum_AX4@XP_635793[RRM1][KOG0145]Nasonia vitripennis@XP_001604889[RRM2][KOG0144]
Dictyostelium discoideum_AX4@XP_636266[RRM1][KOG3598]Endopterygota@CG1316-PA[5][RRM1:100%*][KOG0144:80%*][.KOG0148:20%]
Euteleostomi@ENSDNOP00000001522[23][RRM1:100%***][RBM:61%**][KOG0144:87%**][.KOG0145:13%*]Strongylocentrotus purpuratus@XP_001199679[4][RRM1:100%*][KOG0145:50%]
Dictyostelium discoideum_AX4@XP_629639[RRM1][KOG0145]Bilateria@ENSORLP00000021434[219][RRM1:100%*****][ELAV:79%*****][KOG0145:100%*****]
Diptera@AAEL011150-PA[15][RRM1:100%**][KOG0145:100%**]Drosophila melanogaster@CG5213-PA[RRM1][KOG0145]
Dictyostelium discoideum_AX4@XP_646802[RRM1][KOG0145]Dictyostelium discoideum_AX4@XP_644081[RRM1][KOG0123]
Felis catus@ENSFCAP00000004622[RRM3][PABP][KOG0123]Caenorhabditis elegans@Y106G6H_2a_4[7][RRM3:71%*][.RRM2:29%][KOG0123:100%*]
Caenorhabditis elegans@F18H3_3b[5][RRM3:100%*][KOG0123:100%*]Trypanosoma brucei_TREU927@XP_827358[RRM3][KOG0123]
Leishmania infantum_JPCM5@XP_001469222[RRM3][KOG0123]Ciona@ENSCINP00000018772[3][RRM1:100%*][KOG0127:100%*]
Trypanosoma brucei_TREU927@XP_827237[RRM3][KOG0123]Chlamydomonadales@jgi_Volca1_82578[2][RRM3:100%][PABP:100%][KOG0123:100%]
Strongylocentrotus purpuratus@XP_001177782[4][RRM3:50%][.RRM2:50%][KOG0123:100%*]Dictyostelium discoideum_AX4@XP_629007[RRM3][KOG0123]
Strongylocentrotus purpuratus@XP_001185821[2][RRM1:100%][KOG0670:100%]5 - PABP
+
66 - PABP
10 - ELAV
6 - PABP
12 - ELAV
5 - PABP
11 - ELAV
RBMS
19 - cyclophilin
14 - RBM
part of 67 - UMH
Fungal SR (ScNp13) ?
Fig. S5
79
15.0
51
51
51
59
51
63
79
83
56
65
50
Campylobacter@YP_001467322[2][RRM1:100%][PROK:100%][KOG0148:100%]Candidatus Protochlamydia_amoebophila_UWE25@YP_007892[RRM1][PROK][KOG0149]
Leptospira@YP_000459[4][RRM1:100%*][PROK:100%*][KOG0108:100%*]Syntrophobacter fumaroxidans_MPOB@YP_845575[RRM1][PROK]
Treponema pallidum_subsp._pallidum_str._Nichols@NP_218796[RRM1][PROK][KOG0149]Bacteroidales@YP_213478[13][RRM1:100%**][PROK:100%**][KOG0108:69%**][.KOG0125:31%*]
Bacteroides@YP_001298723[3][RRM1:100%*][PROK:100%*][KOG0108:100%*]Bacteroidales@YP_001302325[2][RRM1:100%][PROK:100%][KOG0123:50%][.KOG0122:50%]
Nitrosococcus oceani_ATCC_19707@YP_344746[RRM1][PROK][KOG0148]Magnoliophyta@29333_m001057[3][RRM2:67%][.RRM1:33%][cpRNP:33%][KOG0131:67%][.KOG0148:33%]
Pezizomycotina@XP_961985[2][RRM2:100%][KOG0116:50%]Schizosaccharomyces pombe_972h-@NP_595090[RRM2]
Magnoliophyta@NP_566958[6][RRM2:67%*][.RRM1:33%][KOG0123:33%][.KOG0124:33%][.KOG0131:33%]Synechococcus_elongatus@YP_399809[2][RRM1:100%][PROK:100%][KOG0108:100%]Cyanobacteria@NP_898344[17][RRM1:100%**][PROK:100%**][KOG0108:65%**]
Ostreococcus@jgi_Ost9901_3_34381[2][RRM1:100%][KOG0145:100%]Cyanobacteria@YP_476186[8][RRM1:100%**][PROK:100%**][KOG0108:38%*][.KOG0122:12%]
Anopheles gambiae@AGAP000921-PA[3][RRM1:100%*]Coelomata@ENSORLP00000004891[62][RRM2:94%****][.RRM1:6%*][RBMS:79%***][KOG0145:100%****]
Tribolium castaneum@XP_971197[RRM1][KOG4661]Coelomata@ENSTBEP00000011040[87][RRM1:98%****][put-sr:16%**][KOG4661:100%****]
Tribolium castaneum@XP_969134[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_33658[RRM1]
Chlamydomonas reinhardtii@jgi_Chlre3_194261[RRM1][KOG0123]Leishmania infantum_JPCM5@XP_001463160[RRM2][put-sr]
Trypanosoma brucei_TREU927@XP_846161[RRM2]Trypanosoma brucei_TREU927@XP_846161[RRM1]
Phytophthora@jgi_Physo1_1_134615[2][RRM1:100%]Aureococcus anophagefferens@jgi_Auran1_66158[RRM2][put-sr][KOG0149]
Strongylocentrotus purpuratus@XP_793862[2][RRM2:100%][KOG0144:100%]Aureococcus anophagefferens@jgi_Auran1_8994[RRM1][KOG0149]
Aureococcus anophagefferens@jgi_Auran1_17889[RRM1][KOG4207]Tribolium castaneum@XP_970765[RRM2][KOG0127]
Encephalitozoon cuniculi_GB-M1@NP_597583[RRM2][KOG4205]Encephalitozoon cuniculi_GB-M1@NP_585962[RRM2][KOG0123]
Strongylocentrotus purpuratus@XP_786044[2][RRM1:100%][KOG0117:100%]Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM2][KOG0110]
Nasonia vitripennis@XP_001605703[RRM1][KOG0127]Apis mellifera@XP_624495[RRM1][KOG0127]
Tribolium castaneum@XP_974350[RRM1][KOG0127]Nasonia vitripennis@XP_001605703[RRM2][KOG0127]
Phytophthora@jgi_Physo1_1_132702[3][RRM3:100%*][KOG0127:100%*]Bacillariophyta@jgi_Phatr2_47737[2][RRM1:100%][put-sr:50%]
Embryophyta@29742_m001371[15][RRM2:80%**][.RRM1:20%*][put-sr:87%**][SR:67%**][KOG0106:100%**]Chlamydomonas reinhardtii@jgi_Chlre3_80366[RRM2][KOG0106]
Chlamydomonas reinhardtii@jgi_Chlre3_120019[RRM2][KOG0106]Saccharomyces cerevisiae@YBR119W[RRM1]Volvox carteri@jgi_Volca1_120369[RRM1][put-sr][KOG0147]
Pezizomycotina@XP_753458[2][RRM2:100%][put-sr:50%][KOG4206:100%]Schizosaccharomyces pombe_972h-@NP_596424[RRM2][KOG4206]
Theileria parva_strain_Muguga@XP_764943[RRM2][KOG4206]Plasmodium falciparum_3D7@XP_001349796[RRM2][KOG4206]
Eukaryota@ENSGACP00000013006[79][RRM2:96%****][snRNP:30%***][KOG4206:100%****]Cryptococcus neoformans_var._neoformans_JEC21@XP_568533[RRM2][KOG4206]
Arabidopsis thaliana@NP_974808[2][RRM1:100%][KOG0123:50%][.KOG0148:50%]rosids@30078_m002213[3][RRM1:100%*][PABP:33%][KOG0123:100%*]
Ricinus communis@30146_m003481[RRM1][KOG0123]Arabidopsis thaliana@NP_188259[RRM1][PABP][KOG0123]
Trypanosomatidae@XP_001469326[2][RRM1:100%][KOG0123:100%]Leishmania infantum_JPCM5@XP_001466041[RRM1][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001049727[RRM1][KOG0123]Trypanosomatidae@XP_001469222[2][RRM1:100%][KOG0123:100%]
Eukaryota@ENSXETP00000023927[236][RRM1:100%*****][PABP:55%****][KOG0123:100%*****]Tetraodon nigroviridis@GSTENP00024897001[RRM1][PABP][KOG0123]
rosids@30078_m002213[3][RRM3:100%*][PABP:33%][KOG0123:100%*]Oryza sativa_japonica_cultivar-group@NP_001049727[RRM3][KOG0123]
Arabidopsis thaliana@NP_195978[RRM1][KOG0123]Cyanidioschyzon merolae@gnl_CMER_CMS187C[RRM1][KOG0123]
Saccharomycetaceae@YFR023W[4][RRM1:100%*][KOG0123:100%*]Candida glabrata_CBS138@XP_447635[RRM1][KOG0123]
Danio rerio@ENSDARP00000091192[14][RRM1:100%**][put-sr:100%**][KOG0123:100%**]Myotis lucifugus@ENSMLUP00000003020[RRM3][PTBP][KOG1190]
Dictyostelium discoideum_AX4@XP_639372[RRM1][KOG0670]Eukaryota@jgi_Volca1_104604[49][RRM1:100%***][put-sr:78%***][KOG0151:100%***]
Plasmodium falciparum_3D7@XP_001348201[RRM1][KOG0151]Cryptococcus neoformans_var._neoformans_JEC21@XP_571608[RRM1][put-sr][KOG0151]
Yarrowia lipolytica@XP_500351[RRM2][KOG0123]Theileria parva_strain_Muguga@XP_766400[RRM2][put-sr][KOG4205]
Amniota@ENSMODP00000004174[11][RRM4:55%*][.RRM3:36%*][.RRM2:9%][put-sr:100%**][KOG0112:100%**]Cryptococcus neoformans_var._neoformans_JEC21@XP_569809[RRM1][KOG0130]
Eukaryota@jgi_Thaps3_18841[52][RRM1:100%***][put-sr:56%***][RBM:42%***][KOG0130:100%***]Phaeodactylum tricornutum@jgi_Phatr2_20716[RRM1][KOG0130]
Plasmodium falciparum_3D7@XP_001348230[RRM1][KOG0130]Yarrowia lipolytica@XP_503462[RRM1][put-sr][KOG0130]Ustilago maydis_521@XP_760711[RRM1][put-sr][KOG0687]
Saccharomycetaceae@XP_453677[2][RRM1:100%][KOG4209:100%]Saccharomyces cerevisiae@YIR001C[RRM1][PABP][KOG4209]
Candida glabrata_CBS138@XP_447800[RRM1][KOG4209]Phytophthora@jgi_Physo1_1_138873[2][RRM1:100%][put-sr:100%][KOG1611:50%]Trypanosomatidae@XP_843959[2][RRM3:100%]
Aedes aegypti@AAEL010887-PA[RRM6][put-sr][KOG1984]Plasmodium falciparum_3D7@XP_001347479[RRM1]
Coelomata@ENSOGAP00000009767[86][RRM1:100%****][hnRNP:34%***][KOG4212:100%****]Strongylocentrotus purpuratus@XP_001187716[4][RRM1:100%*][put-sr:100%*][KOG4212:50%][.KOG4661:50%]
Schizosaccharomyces pombe_972h-@NP_588373[RRM1]Ostreococcus tauri@jgi_Ostta4_31833[RRM2][KOG0148]
3 - PABP
41 - snRNP
56 - green plant-specific
RS group of SR proteins
part of 68 - FOX
88 - prokaryotic RRMs
13
Fig. S5
80
74 75
79 52
71
95
57
77
85
Bilateria@Y47G6A 20a[64][RRM1:100%****][UMH:73%***][KOG0124:100%****]Phaeodactylum tricornutum@jgi_Phatr2_10122[RRM1][KOG0153]
Phytophthora@jgi_Physo1_1_140403[2][RRM1:100%][put-sr:100%][KOG0127:100%]Dictyostelium discoideum_AX4@XP_641373[RRM1][put-sr]
Strongylocentrotus purpuratus@XP_001185906[2][RRM1:100%][KOG0107:100%]Dictyostelium discoideum_AX4@XP_001134500[RRM1][put-sr][KOG0147]
Yarrowia lipolytica@XP_500797[RRM1][put-sr]Schizosaccharomyces pombe_972h-@NP_596398[RRM1][put-sr][SR]
Ustilago maydis_521@XP_758616[RRM1]Volvox carteri@jgi_Volca1_72841[RRM1][KOG0144]
Bilateria@ENSSARP00000011721[82][RRM1:100%****][TIATIAR:80%****][KOG0148:100%****]Chlamydomonadales@jgi_Volca1_107765[2][RRM1:100%][KOG0145:100%]
Chlamydomonadales@jgi_Volca1_48801[2][RRM1:100%][KOG0120:100%]Eukaryota@jgi_Volca1_82970[75][RRM2:91%****][.RRM1:9%*][put-sr:80%****][snRNP:53%***][KOG0120:100%****]
Phaeodactylum tricornutum@jgi_Phatr2_11145[RRM2][KOG0120]Plasmodium falciparum_3D7@XP_001348830[RRM2][put-sr][KOG0120]
Schizosaccharomyces pombe_972h-@NP_595396[RRM1][put-sr][KOG0120]Pezizomycotina@XP_387225[3][RRM1:67%][.RRM2:33%][put-sr:100%*][KOG0120:100%*]
Yarrowia lipolytica@XP_503754[RRM1][KOG0120]Aspergillus fumigatus_Af293@XP_747328[RRM1][KOG0110]
Eukaryota@NP_001063859[35][RRM1:100%***][ZCRB1:69%***][KOG0108:40%**][.KOG0122:9%*][.KOG0117:6%][.KOG0107:6%]Aedes aegypti@AAEL006197-PA[RRM1][KOG0108]
Phytophthora ramorum@jgi_Phyra1_1_94226[RRM1][put-sr][KOG0941]Volvox carteri@jgi_Volca1_107013[RRM3][KOG0117]
Theileria parva_strain_Muguga@XP_766553[RRM1][KOG4208]Cyanidioschyzon merolae@gnl_CMER_CMI122C[RRM1][KOG4208]
Dictyostelium discoideum_AX4@XP_643547[RRM1]Thalassiosira pseudonana@jgi_Thaps3_18198[RRM1][KOG4208]
Phaeodactylum tricornutum@jgi_Phatr2_45356[RRM1][KOG4208]Caenorhabditis elegans@T04A8_6[RRM1][KOG4208]
Eukaryota@CG6937-PA[73][RRM1:100%****][put-sr:5%*][KOG4208:99%****]Anopheles gambiae@AGAP006090-PA[RRM1]
Plasmodium falciparum_3D7@XP_001348607[RRM1]Plasmodium falciparum_3D7@XP_966276[RRM2]
Aedes aegypti@AAEL010887-PA[RRM6][put-sr][KOG1984]Dictyostelium discoideum_AX4@XP_642758[RRM1]
Strongylocentrotus purpuratus@XP_001185731[2][RRM1:100%]Tribolium castaneum@XP_971953[RRM1]
Euteleostomi@ENSMODP00000018834[25][RRM1:100%***][put-sr:64%**][KOG0147:48%**][.KOG0132:12%*]Plasmodium falciparum_3D7@XP_001348230[RRM1][KOG0130]
Phaeodactylum tricornutum@jgi_Phatr2_20716[RRM1][KOG0130]Eukaryota@jgi_Thaps3_18841[52][RRM1:100%***][put-sr:56%***][RBM:42%***][KOG0130:100%***]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569809[RRM1][KOG0130]Ustilago maydis_521@XP_760711[RRM1][put-sr][KOG0687]
Yarrowia lipolytica@XP_503462[RRM1][put-sr][KOG0130]Cryptococcus neoformans_var._neoformans_JEC21@XP_569824[RRM1][put-sr]
Schizosaccharomyces pombe_972h-@NP_596549[RRM1][put-sr]Sordariomycetes@XP_001522188[3][RRM1:100%*][put-sr:67%]
Caenorhabditis elegans@K02F3_11_2[2][RRM1:100%][put-sr:100%][KOG4209:100%]Coelomata@ENSMUSP00000057332[45][RRM1:100%***][put-sr:100%***][RNPS1:64%***][KOG4209:87%***]
Dictyostelium discoideum_AX4@XP_636445[RRM1][put-sr]Viridiplantae@jgi_Phypa1_1_105411[8][RRM1:100%**][put-sr:100%**][SR:25%][KOG0117:12%][.KOG0462:12%]
Phytophthora@jgi_Physo1_1_138873[2][RRM1:100%][put-sr:100%][KOG1611:50%]Eukaryota@AAEL002461-PA[78][RRM1:100%****][put-sr:29%***][KOG0126:100%****]
Ustilago maydis_521@XP_760864[RRM1][KOG0126]Saccharomycetaceae@XP_459205[2][RRM1:100%][KOG0126:100%]
Trypanosoma brucei_TREU927@XP_845742[RRM1][KOG0126]Apis mellifera@XP_394565[RRM1][KOG0147]
Schizosaccharomyces pombe_972h-@NP_593427[RRM1][KOG0123]Drosophila melanogaster@CG3312-PA[2][RRM1:100%][KOG0128:100%]
Saccharomyces cerevisiae@YLL046C[RRM1]Mammalia@ENSETEP00000003776[19][RRM1:100%**][LA:95%**][KOG4213:100%**]
Anopheles gambiae@AGAP007689-PA[RRM1]Aedes aegypti@AAEL010101-PA[RRM1]Tribolium castaneum@XP_969873[RRM1]
Strongylocentrotus purpuratus@XP_001185821[2][RRM1:100%][KOG0670:100%]Euteleostomi@ENSOANP00000024755[113][RRM1:100%****][hnRNP:36%***][.RALYL:15%**]
Apocrita@XP_623710[2][RRM1:100%]Saccharomycetales@XP_454821[4][RRM1:100%*][KOG3598:50%][.KOG1984:25%]
Dictyostelium discoideum_AX4@XP_638672[RRM1][put-sr][KOG0147]Plasmodium falciparum_3D7@XP_001347332[RRM1][put-sr][KOG0105]
Pichia stipitis_CBS_6054@XP_001384462[RRM2]Debaryomyces hansenii_CBS767@XP_460517[RRM2][KOG0117]
Saccharomycetales@XP_445844[3][RRM2:100%*][KOG0123:33%]Kluyveromyces lactis@XP_455897[RRM2][KOG0123]
Coxiella_burnetii@YP_001424629[2][RRM1:100%][PROK:100%][KOG0108:100%]Legionella_pneumophila@YP_001249669[3][RRM1:100%*][PROK:100%*][put-sr:100%*][KOG0149:100%*]
Ostreococcus lucimarinus@jgi_Ost9901_3_7602[RRM1][KOG0145]Dictyostelium discoideum_AX4@XP_641568[RRM2][KOG3598]
Deuterostomia@ENSDNOP00000008593[94][RRM1:100%****][P54nrb:28%***][.PSP1:21%**][.PSF:18%**][KOG0115:99%****]Caenorhabditis elegans@F25B5_7d[2][RRM1:100%][KOG0115:100%]
Endopterygota@CG10328-PA[9][RRM1:100%**][P54nrb:33%*][KOG0115:100%**]Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM2][KOG0110]
Trypanosomatidae@XP_001463723[2][RRM1:100%][KOG0110:100%]Phytophthora@jgi_Physo1_1_129427[2][RRM2:100%][KOG0110:100%]
Oryza sativa_japonica_cultivar-group@NP_001053839[RRM1][KOG0110]Bilateria@ENSORLP00000004891[130][RRM1:100%****][RBMS:72%****][KOG0145:99%****]
Schizosaccharomyces pombe_972h-@NP_595599[RRM2][KOG0110]Saccharomycetales@NP_984131[7][RRM2:100%*][KOG0110:100%*]
Aspergillus fumigatus_Af293@XP_750233[RRM2][KOG0110]Caenorhabditis elegans@T23F6_4_1[2][RRM3:100%][KOG0110:100%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569873[RRM2][KOG0110]Neurospora crassa_OR74A@XP_965014[RRM2][KOG0110]
Phaeodactylum tricornutum@jgi_Phatr2_20740[RRM2][KOG0110]Ustilago maydis_521@XP_758493[RRM2][KOG0110]
Aureococcus anophagefferens@jgi_Auran1_1296[RRM1][KOG0110]Eukaryota@IMGA_AC183923_6_1[34][RRM3:74%***][.RRM1:15%*][.RRM2:12%*][put-sr:6%][KOG0110:100%***]
Thalassiosira pseudonana@jgi_Thaps3_268689[RRM2][KOG0110]Arabidopsis thaliana@NP_567594[RRM1][KOG0117]
eurosids_I@IMGA_CT963106_6_1[2][RRM1:100%][KOG0117:50%]
>>> RRM1 of SR45/RNPS1
86 - hnRNP/RALYL
84 - La
31
32
33 - p54nrb
PSP1
PSF
69
20 - RBM
27 - RNPS1
26 - SR45
28
82
57 - ZCRB1
64 - snRNP
76 - TIA TIAR
OligoU
67 - UMH
PROK
Fungal SR (SpSrp1)
Fungal SpRnps1
Fig. S6
81
82
78
68
83
61
69
55
56
67
57
72
99
76
62
Debaryomyces hansenii CBS767@XP 459815[RRM1][KOG0415]Eukaryota@jgi_Ostta4_3181[66][RRM1:100%****][put-sr:47%***][cyclophilin:32%***][KOG0415:97%****]
Leishmania infantum_JPCM5@XP_001463468[RRM1]Trypanosomatidae@XP_829274[2][RRM1:100%][KOG0145:50%]
Trypanosoma brucei_TREU927@XP_829272[RRM1][KOG0145]Leishmania infantum_JPCM5@XP_001463465[RRM1][KOG0122]
Encephalitozoon cuniculi_GB-M1@NP_586099[RRM2][KOG0131]Phaeodactylum tricornutum@jgi_Phatr2_44468[RRM1]
Thalassiosira pseudonana@jgi_Thaps3_20887[RRM1]Encephalitozoon cuniculi_GB-M1@NP_586226[RRM2][put-sr][KOG0123]
Ashbya gossypii_ATCC_10895@NP_984845[RRM2][KOG0123]Schizosaccharomyces pombe_972h-@NP_001018242[RRM3][KOG0123]
Schizosaccharomyces pombe_972h-@NP_593427[RRM2][KOG0123]Leishmania infantum_JPCM5@XP_001466041[RRM2][KOG0123]Arabidopsis thaliana@NP_174676[RRM1][PABP][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001049727[RRM2][KOG0123]rosids@30078_m002213[3][RRM2:100%*][PABP:33%][KOG0123:100%*]
rosids@30146_m003481[2][RRM2:100%][PABP:50%][KOG0123:100%]Phytophthora sojae@jgi_Physo1_1_139371[RRM2][KOG4205]
Eukaryota@jgi_Volca1_104604[49][RRM1:100%***][put-sr:78%***][KOG0151:100%***]Plasmodium falciparum_3D7@XP_001348201[RRM1][KOG0151]
Cryptococcus neoformans_var._neoformans_JEC21@XP_571608[RRM1][put-sr][KOG0151]Ostreococcus tauri@jgi_Ostta4_31833[RRM2][KOG0148]
Eukaryota@YHR086W[51][RRM3:76%***][.RRM2:20%**][oligoU:10%*][KOG0148:90%***]Schizosaccharomyces pombe_972h-@NP_594243[RRM3][KOG0148]
Aureococcus anophagefferens@jgi_Auran1_28594[RRM3][KOG0148]Phytophthora@jgi_Phyra1_1_50314[2][RRM3:100%][KOG0148:100%]
Coelomata@XP_975014[28][RRM1:100%***][RBM:86%***][KOG0153:100%***]Caenorhabditis elegans@T11G6_8_1[2][RRM1:100%][KOG0153:100%]Ciona@ENSCSAVP00000015574[2][RRM1:100%][KOG0153:100%]
Ostreococcus@jgi_Ost9901_3_41266[2][RRM1:100%][KOG0153:100%]Embryophyta@jgi_Phypa1_1_185655[7][RRM1:100%*][KOG0153:100%*]
Encephalitozoon cuniculi_GB-M1@NP_584552[RRM3][KOG0123]Theria@ENSMODP00000002817[2][RRM1:100%]
Theileria parva_strain_Muguga@XP_764943[RRM1][KOG4206]Pichia stipitis_CBS_6054@XP_001382592[RRM1][KOG4206]
Coelomata@ENSORLP00000008206[18][RRM1:100%**][snRNP:83%**][KOG4206:100%**]Sordariomycetes@XP_962704[2][RRM1:100%][put-sr:50%][KOG4206:100%]
Endopterygota@CG4266-PA[5][RRM1:100%*][put-sr:100%*][KOG0132:100%*]Eutheria@ENSETEP00000000464[10][RRM1:100%**][put-sr:100%**][KOG0132:100%**]
Ciona intestinalis@ENSCINP00000027768[RRM1][KOG0548]Dictyostelium discoideum_AX4@XP_635179[RRM2][KOG0148]
Strongylocentrotus purpuratus@XP_001188888[2][RRM1:100%][KOG0548:100%]Clupeocephala@ENSORLP00000009616[3][RRM1:100%*][KOG0548:100%*]
Gasterosteus aculeatus@ENSGACP00000006521[RRM1][KOG0548]Danio rerio@ENSDARP00000075089[2][RRM1:100%][KOG0548:100%]
Physcomitrella patens@jgi_Phypa1_1_161310[RRM3][KOG3598]Saccharomyces cerevisiae@YMR302C[RRM1]
Physcomitrella patens@jgi_Phypa1_1_137240[2][RRM1:100%][KOG3598:50%]Arabidopsis thaliana@NP_181869[4][RRM1:100%*][FCAFPA:100%*][KOG0117:100%*]
Ricinus communis@29577_m000447[RRM1][KOG0123]Ricinus communis@30005_m001243[RRM1]
Oryza sativa_japonica_cultivar-group@NP_001062811[RRM1][KOG1190]Dictyostelium discoideum_AX4@XP_644288[RRM1][KOG3598]
Dictyostelium discoideum_AX4@XP_644288[RRM2][KOG3598]Schizosaccharomyces pombe_972h-@NP_588373[RRM1]
Physcomitrella patens@jgi_Phypa1_1_176266[RRM1][KOG1924]Oryza sativa_japonica_cultivar-group@NP_001063671[RRM2][KOG0123]rosids@NP_001078046[5][RRM2:100%*][FCAFPA:80%*][KOG0117:80%*][.KOG0123:20%]
Physcomitrella patens@jgi_Phypa1_1_161310[RRM2][KOG3598]Dictyostelium discoideum_AX4@XP_629218[RRM1][KOG0151]
Dictyostelium discoideum_AX4@XP_629218[RRM2][KOG0151]Volvox carteri@jgi_Volca1_88720[RRM3]
Chlamydomonas reinhardtii@jgi_Chlre3_148816[RRM2][KOG3598]Schizosaccharomyces pombe_972h-@NP_595389[RRM1][KOG4574]
Yarrowia lipolytica@XP_500252[RRM1][KOG4574]Cryptococcus neoformans_var._neoformans_JEC21@XP_570411[RRM2][KOG4574]
Neurospora crassa_OR74A@XP_962915[RRM1][KOG4574]Dictyostelium discoideum_AX4@XP_638262[RRM2][put-sr][KOG0670]
Cryptosporidium parvum_Iowa_II@XP_628096[RRM2][put-sr][KOG0124]Bilateria@ENSCSAVP00000007991[62][RRM2:95%****][.RRM1:5%*][UMH:74%***][KOG0124:100%****]
Phytophthora@jgi_Phyra1_1_84640[3][RRM2:67%][.RRM1:33%][KOG0124:67%][.KOG0120:33%]Dictyostelium discoideum_AX4@XP_638262[RRM1][put-sr][KOG0670]
Dictyostelium discoideum_AX4@XP_643007[RRM1]Eukaryota@ENSFCAP00000006163[84][RRM2:88%****][.RRM1:12%**][put-sr:86%****][UMH:39%***][.CAPER:8%*][KOG0147:100%****]
Bacillariophyta@jgi_Phatr2_20857[2][RRM2:100%][put-sr:100%][KOG0147:100%]Volvox carteri@jgi_Volca1_84128[RRM2][KOG0147]
Phytophthora@jgi_Phyra1_1_94266[2][RRM2:100%][KOG0147:100%]Plasmodium falciparum_3D7@XP_001349956[RRM2][KOG0147]
Ascomycota@XP_385341[4][RRM2:100%*][put-sr:100%*][KOG0147:100%*]Cryptococcus neoformans_var._neoformans_JEC21@XP_571060[RRM2][KOG0147]
Caenorhabditis elegans@Y55F3AM_3c_1[3][RRM2:100%*][put-sr:33%][UMH:100%*][KOG0147:100%*]Ustilago maydis_521@XP_756311[RRM2][put-sr][KOG0147]
Cryptosporidium parvum_Iowa_II@XP_628096[RRM1][put-sr][KOG0124]Phytophthora ramorum@jgi_Phyra1_1_81440[2][RRM1:100%][KOG0124:100%]
Yarrowia lipolytica@XP_504318[RRM2][KOG0147]Volvox carteri@jgi_Volca1_106063[RRM2]
Dictyostelium discoideum_AX4@XP_636266[RRM3][KOG3598]Encephalitozoon cuniculi_GB-M1@NP_585962[RRM2][KOG0123]
Aspergillus fumigatus_Af293@XP_749317[RRM3][KOG0128]Schizosaccharomyces pombe_972h-@NP_596721[RRM3][KOG0128]
Percomorpha@ENSGACP00000011877[6][RRM1:100%*][KOG0123:100%*]Gallus gallus@ENSGALP00000012472[2][RRM1:100%][KOG0123:100%]
Schizosaccharomyces pombe_972h-@NP_593531[RRM2][nucleolin][KOG0147]Ustilago maydis_521@XP_762340[RRM2][KOG0148]
Cryptococcus neoformans_var._neoformans_JEC21@XP_566835[RRM2][KOG0148]Saccharomycetales@XP_456900[7][RRM2:100%*][nucleolin:14%][KOG0148:57%*][.KOG0131:29%][.KOG4210:14%]Pezizomycotina@XP_754840[2][RRM2:100%][KOG0127:50%][.KOG0148:50%]
Aspergillus fumigatus_Af293@XP_754657[RRM1]Yarrowia lipolytica@XP_500351[RRM1][KOG0123]
Neurospora crassa_OR74A@XP_964541[RRM1]Aspergillus fumigatus_Af293@XP_748929[RRM1]
Aureococcus anophagefferens@jgi_Auran1_69134[RRM1][put-sr]Pezizomycotina@XP_961985[2][RRM1:100%][KOG0116:50%]
Theileria parva_strain_Muguga@XP_765501[RRM1][KOG0127]Candida glabrata_CBS138@XP_445637[RRM1]
Ashbya gossypii_ATCC_10895@NP_983970[RRM1]Ciona intestinalis@ENSCINP00000008726[RRM1][put-sr][KOG2193]
Apis mellifera@XP_393878[RRM1][put-sr][KOG2193]Takifugu rubripes@SINFRUP00000134535[RRM1][KOG0123]
Aspergillus fumigatus_Af293@XP_750045[RRM1]Ostreococcus lucimarinus@jgi_Ost9901_3_32831[RRM1]
Debaryomyces hansenii_CBS767@XP_460681[RRM3][KOG0128]Plasmodium falciparum_3D7@XP_001347479[RRM1]
Saccharomyces cerevisiae@YMR268C[RRM3][KOG0128]Candida glabrata_CBS138@XP_446891[RRM3][KOG0128]
Aedes aegypti@AAEL010888-PA[RRM2]Dictyostelium discoideum_AX4@XP_646584[RRM2][KOG0127]
Coxiella_burnetii@YP_001424503[2][RRM1:100%][PROK:100%][KOG0113:100%]Bilateria@Y47G6A_20a[64][RRM1:100%****][UMH:73%***][KOG0124:100%****]
67 - UMH
40 - snRNP
14 - RBM
78 - OligoU
13
38 - Cyclophilin
PROK
Fig. S6
82
55
80
77
94
62
85
76
66 60
83
53
78
81
51
82
Leishmania infantum JPCM5@XP 001466041[RRM4][KOG0123]Drosophila melanogaster@CG4612-PA[RRM2][KOG0123]
Aedes aegypti@AAEL007013-PA[RRM1][KOG0123]Arabidopsis thaliana@NP_188259[RRM4][PABP][KOG0123]
Eukaryota@ENSDNOP00000002400[249][RRM4:82%*****][.RRM3:11%***][.RRM2:6%**][PABP:54%****][KOG0123:100%*****]Pezizomycotina@XP_750167[2][RRM4:100%][KOG0123:100%]
Strongylocentrotus purpuratus@XP_001177782[4][RRM3:50%][.RRM2:50%][KOG0123:100%*]Dictyostelium discoideum_AX4@XP_629007[RRM3][KOG0123]
Chlamydomonadales@jgi_Volca1_82578[2][RRM3:100%][PABP:100%][KOG0123:100%]Dikarya@XP_960425[12][RRM3:100%**][PABP:17%][KOG0123:100%**]
Yarrowia lipolytica@XP_501289[RRM3][KOG0123]Trypanosoma brucei_TREU927@XP_827237[RRM3][KOG0123]
Trypanosoma brucei_TREU927@XP_827358[RRM3][KOG0123]Leishmania infantum_JPCM5@XP_001469222[RRM3][KOG0123]
Felis catus@ENSFCAP00000004622[RRM3][PABP][KOG0123]Caenorhabditis elegans@Y106G6H_2a_4[7][RRM3:71%*][.RRM2:29%][KOG0123:100%*]
Caenorhabditis elegans@F18H3_3b[5][RRM3:100%*][KOG0123:100%*]Echinops telfairi@ENSETEP00000008100[RRM3][PABP][KOG0123]
Phytophthora@jgi_Physo1_1_108322[2][RRM3:100%][KOG0123:100%]Thalassiosira pseudonana@jgi_Thaps3_13224[RRM3][KOG0123]
Phaeodactylum tricornutum@jgi_Phatr2_23959[RRM3][KOG0123]Aureococcus anophagefferens@jgi_Auran1_60739[RRM1][put-sr][KOG1860]
Trypanosomatidae@XP_847111[2][RRM1:100%]Leishmania infantum_JPCM5@XP_001465764[RRM1]
Trypanosoma brucei_TREU927@XP_846161[RRM2]Trypanosoma brucei_TREU927@XP_846161[RRM1]
Leishmania infantum_JPCM5@XP_001463160[RRM2][put-sr]Trypanosomatidae@XP_001469326[2][RRM1:100%][KOG0123:100%]
Leishmania infantum_JPCM5@XP_001466041[RRM1][KOG0123]Trypanosomatidae@XP_001469222[2][RRM1:100%][KOG0123:100%]
Eukaryota@ENSXETP00000023927[236][RRM1:100%*****][PABP:55%****][KOG0123:100%*****]Tetraodon nigroviridis@GSTENP00024897001[RRM1][PABP][KOG0123]Saccharomycetaceae@YFR023W[4][RRM1:100%*][KOG0123:100%*]
Candida glabrata_CBS138@XP_447635[RRM1][KOG0123]Danio rerio@ENSDARP00000091192[14][RRM1:100%**][put-sr:100%**][KOG0123:100%**]
rosids@30078_m002213[3][RRM1:100%*][PABP:33%][KOG0123:100%*]Oryza sativa_japonica_cultivar-group@NP_001049727[RRM1][KOG0123]
Ricinus communis@30146_m003481[RRM1][KOG0123]Arabidopsis thaliana@NP_188259[RRM1][PABP][KOG0123]
Dictyostelium discoideum_AX4@XP_645138[RRM1]Chlamydomonas reinhardtii@jgi_Chlre3_181993[RRM1]
Theileria parva_strain_Muguga@XP_766466[RRM3][KOG0123]Cryptosporidium parvum_Iowa_II@XP_001388334[RRM3][KOG0123]
Embryophyta@jgi_Phypa1_1_140180[4][RRM3:100%*][KOG0117:100%*]Trypanosoma brucei_TREU927@XP_844190[RRM1][KOG0144]
Ascomycota@YDL224C[8][RRM1:88%*][.RRM2:12%][KOG3598:12%][.KOG1457:12%]Medicago truncatula@IMGA_CU012061_4_1[RRM1]
Ricinus communis@28452_m000049[RRM1][KOG1457]Plasmodium falciparum_3D7@XP_001350640[RRM3][KOG0123]
Encephalitozoon cuniculi_GB-M1@NP_584552[RRM1][KOG0123]Debaryomyces hansenii_CBS767@XP_460681[RRM2][KOG0128]
Saccharomyces cerevisiae@YMR268C[RRM2][KOG0128]Schizosaccharomyces pombe_972h-@NP_596721[RRM2][KOG0128]
Pezizomycotina@XP_749317[2][RRM2:100%][KOG0128:100%]Dictyostelium discoideum_AX4@XP_638966[RRM2][KOG0147]Plasmodium falciparum_3D7@XP_001347876[RRM1][KOG0105]
Dictyostelium discoideum_AX4@XP_645848[RRM2][put-sr]Saccharomycetales@XP_454345[4][RRM1:100%*][KOG0148:75%*][.KOG0123:25%]
Yarrowia lipolytica@XP_501542[RRM1][KOG0131]Saccharomycetaceae@XP_001383142[2][RRM1:100%][put-sr:100%][KOG0148:100%]
Sordariomycetes@XP_385593[2][RRM1:100%][KOG0148:100%]Cryptococcus neoformans_var._neoformans_JEC21@XP_570577[RRM1][KOG0148]
Embryophyta@NP_188026[13][RRM1:100%**][oligoU:38%*][KOG0148:100%**]Ustilago maydis_521@XP_757329[RRM1][KOG0145]
Aureococcus anophagefferens@jgi_Auran1_31715[RRM1][KOG0149]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM5][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM4][KOG0123]Embryophyta@jgi_Phypa1_1_189930[7][RRM1:100%*][KOG0119:86%*][.KOG0307:14%]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM6][KOG0123]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM1][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM3][KOG0123]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM2][KOG0123]
Culicidae@AAEL001131-PA[2][RRM1:100%][KOG0113:100%]Ciona@ENSCSAVP00000018820[2][RRM2:100%][KOG0145:100%]
Euteleostomi@ENSXETP00000044031[49][RRM2:76%***][.RRM1:24%**][KOG0145:41%**][.KOG0123:14%*][.KOG0110:14%*]Dictyostelium discoideum_AX4@XP_635793[RRM1][KOG0145]
Dictyostelium discoideum_AX4@XP_635793[RRM2][KOG0145]Dictyostelium discoideum_AX4@XP_644081[RRM2][KOG0123]
Trypanosomatidae@XP_001468777[2][RRM2:100%][KOG0144:100%]Trypanosomatidae@XP_847495[2][RRM1:100%][KOG0110:50%][.KOG0127:50%]
Nasonia vitripennis@XP_001604889[RRM2][KOG0144]Dictyostelium discoideum_AX4@XP_636266[RRM1][KOG3598]
Endopterygota@CG1316-PA[5][RRM1:100%*][KOG0144:80%*][.KOG0148:20%]Strongylocentrotus purpuratus@XP_001199679[4][RRM1:100%*][KOG0145:50%]
Euteleostomi@ENSDNOP00000001522[23][RRM1:100%***][RBM:61%**][KOG0144:87%**][.KOG0145:13%*]Leishmania infantum_JPCM5@XP_001464836[RRM1][KOG0145]
Leishmania infantum_JPCM5@XP_001464835[2][RRM1:100%][KOG0145:100%]Leishmania infantum_JPCM5@XP_001466666[RRM1][KOG0145]
Trypanosoma brucei_TREU927@XP_843985[3][RRM1:100%*][put-sr:33%][KOG0110:100%*]Leishmania infantum_JPCM5@XP_001466665[RRM1][KOG0110]
Leishmania infantum_JPCM5@XP_001466659[RRM1][KOG0145]Embryophyta@NP_001063403[14][RRM1:100%**][KOG0148:100%**]
Endopterygota@XP_974444[2][RRM1:100%][KOG0144:100%]Clupeocephala@ENSORLP00000016619[5][RRM1:100%*][KOG0131:60%*][.KOG0123:40%]
Dictyostelium discoideum_AX4@XP_639372[RRM1][KOG0670]Embryophyta@NP_001062111[8][RRM1:100%**][put-sr:62%*][KOG4849:38%*][.KOG4246:12%][.KOG0113:12%][.KOG4676:12%]
Ostreococcus lucimarinus@jgi_Ost9901_3_26750[RRM1]Trypanosomatidae@XP_843886[2][RRM1:100%][KOG0145:100%]
Trypanosomatidae@XP_828145[5][RRM1:100%*][KOG0145:100%*]Trypanosoma brucei_TREU927@XP_845996[RRM1][KOG0122]
Drosophila melanogaster@CG5213-PA[RRM1][KOG0145]Diptera@AAEL011150-PA[15][RRM1:100%**][KOG0145:100%**]
Dictyostelium discoideum_AX4@XP_629639[RRM1][KOG0145]Bilateria@ENSORLP00000021434[219][RRM1:100%*****][ELAV:79%*****][KOG0145:100%*****]Dictyostelium discoideum_AX4@XP_644081[RRM1][KOG0123]
Dictyostelium discoideum_AX4@XP_646802[RRM1][KOG0145]Dictyostelium discoideum_AX4@XP_644081[RRM3][KOG0123]
Ciona@ENSCINP00000023191[4][RRM3:75%*][.RRM1:25%][KOG0145:100%*]Coelomata@ENSTBEP00000015452[229][RRM3:88%*****][.RRM2:9%**][ELAV:82%*****][KOG0145:100%*****]
Dictyostelium discoideum_AX4@XP_635793[RRM3][KOG0145]Caenorhabditis elegans@F35H8_5[RRM3][KOG0145]
Aconoidasida@XP_001349292[3][RRM2:100%*][KOG0146:67%][.KOG0144:33%]Plasmodium falciparum_3D7@XP_001350320[RRM3][KOG0123]
Plasmodium falciparum_3D7@XP_001350320[RRM2][KOG0123]Theileria parva_strain_Muguga@XP_766017[RRM3][KOG0144]
Cryptosporidium parvum_Iowa_II@XP_001388078[RRM3][put-sr][KOG0144]Eukaryota@ENSOANP00000006980[251][RRM3:67%*****][.RRM2:24%****][.RRM1:10%***][Bruno:50%****][KOG0144:55%****][.KOG0146:45%****]
Cryptosporidium parvum_Iowa_II@XP_626331[RRM1][KOG0146]Cyanidioschyzon merolae@gnl_CMER_CMS187C[RRM1][KOG0123]
Debaryomyces hansenii_CBS767@XP_459815[RRM1][KOG0415] 38 Cyclophilin
9 - Bruno
12 - ELAV
10 - ELAV
3 - PABP
5 - PABP
6 - PABP
associated to node 76
in 3 other trees
Fig. S6
83
70 63
68
92
71
66
52
62
91
72
94
60 73
99
70
83
Magnoliophyta@29709 m001182[6][RRM1:100%*][put sr:17%][KOG0117:100%*]Ricinus communis@30072_m000974[RRM1][KOG0117]
Oryza sativa_japonica_cultivar-group@NP_001064224[RRM1][KOG0117]Cyanidioschyzon merolae@gnl_CMER_CMG025C[RRM1][KOG1080]
Ricinus communis@30169_m006629[RRM1][KOG0123]Euteleostomi@ENSOANP00000013028[22][RRM1:100%***]
Drosophila melanogaster@CG14414-PB[RRM1]Endopterygota@XP_967886[3][RRM1:100%*]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572996[RRM1]Ustilago maydis_521@XP_760296[RRM1]
Thalassiosira pseudonana@jgi_Thaps3_2206[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_38474[RRM1]
Nasonia vitripennis@XP_001604488[RRM1]Oryza sativa_japonica_cultivar-group@NP_001067112[RRM2][put-sr][KOG0117]
Zea mays@11279_m000026_AZM5_6772[RRM1][put-sr][KOG0117]Coelomata@XP_974651[54][RRM2:83%***][.RRM1:17%**][put-sr:87%***][RBM:37%**][KOG0112:100%***]
Drosophila melanogaster@CG2050-PA[RRM3]Coelomata@ENSMMUP00000010529[37][RRM3:54%**][.RRM2:41%**][.RRM1:5%][put-sr:92%***][KOG0112:84%***][.KOG3598:8%*]
Strongylocentrotus purpuratus@XP_001184502[2][RRM2:100%][put-sr:100%][KOG1144:100%]Strongylocentrotus purpuratus@XP_786044[2][RRM1:100%][KOG0117:100%]
Neurospora crassa_OR74A@XP_958552[RRM1][KOG0128]Dictyostelium discoideum_AX4@XP_641568[RRM3][KOG3598]
Aedes aegypti@AAEL010890-PA[RRM1][put-sr][KOG0132]Theileria parva_strain_Muguga@XP_766728[RRM1][KOG0124]
Trypanosomatidae@XP_827358[2][RRM2:100%][KOG0123:100%]Plasmodium falciparum_3D7@XP_001352162[RRM1]
Plasmodium falciparum_3D7@XP_001351468[RRM1]Encephalitozoon cuniculi_GB-M1@NP_597181[RRM1][KOG0110]
Schizosaccharomyces pombe_972h-@NP_595599[RRM1][KOG0110]Saccharomycetaceae@XP_001386803[2][RRM1:100%][KOG0110:100%]
Viridiplantae@jgi_Phypa1_1_207810[3][RRM1:100%*][KOG0110:100%*]Dictyostelium discoideum_AX4@XP_638463[RRM1][KOG0110]
Ustilago maydis_521@XP_758493[RRM1][KOG0110]Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM1][KOG0110]
Arabidopsis thaliana@NP_196191[RRM1][KOG0110]Apocrita@XP_624611[2][RRM1:100%][KOG0110:100%]
Drosophila melanogaster@CG3335-PA[RRM1][KOG0110]Caenorhabditis elegans@T23F6_4_1[2][RRM1:100%][KOG0110:100%]
Culicidae@AGAP005249-PA[2][RRM1:100%][KOG0110:100%]Euteleostomi@GSTENP00029551001[21][RRM1:100%***][put-sr:10%][KOG0110:100%***]
Drosophila melanogaster@CG5213-PA[RRM2][KOG0145]Diptera@AGAP003899-PA[15][RRM2:100%**][KOG0145:100%**]
Ustilago maydis_521@XP_759141[RRM2][KOG0145]Coelomata@ENSORLP00000004891[62][RRM2:94%****][.RRM1:6%*][RBMS:79%***][KOG0145:100%****]
Bilateria@CG3151-PE[218][RRM2:92%*****][.RRM1:7%**][ELAV:84%*****][KOG0145:100%*****]Ciona@ENSCSAVP00000015853[4][RRM2:100%*][KOG0145:100%*]
Plasmodium falciparum_3D7@XP_001349292[RRM1][KOG0146]Theileria parva_strain_Muguga@XP_766722[RRM1][KOG0144]
Aconoidasida@XP_766017[2][RRM2:100%][KOG0144:100%]Plasmodium falciparum_3D7@XP_001348269[RRM2][KOG0144]
Cryptosporidium parvum_Iowa_II@XP_001388078[RRM2][put-sr][KOG0144]Thalassiosira pseudonana@jgi_Thaps3_261541[RRM2][KOG0144]Chlamydomonadales@jgi_Chlre3_99329[2][RRM1:50%][.RRM2:50%][KOG0144:100%]Chlamydomonadales@jgi_Volca1_88093[2][RRM1:100%][KOG1240:100%]
Embryophyta@jgi_Phypa1_1_115029[9][RRM2:100%**][KOG0144:100%**]Arabidopsis thaliana@NP_850472[RRM2][FCAFPA][KOG0144]
Embryophyta@29889_m003323[11][RRM2:100%**][FCAFPA:18%][KOG0144:100%**]Phytophthora@jgi_Physo1_1_133760[2][RRM2:100%][KOG0144:100%]Bilateria@AGAP009477-PA[250][RRM2:73%*****][.RRM1:27%****][Bruno:59%****][KOG0144:56%****][.KOG0146:44%****]
Dictyostelium discoideum_AX4@XP_635247[RRM2][KOG0144]Dictyostelium discoideum_AX4@XP_646268[RRM2][KOG0146]
Trypanosomatidae@XP_845656[2][RRM1:100%][KOG0131:50%]Leishmania infantum_JPCM5@XP_001468236[RRM1]Trypanosomatidae@XP_001468238[3][RRM1:100%*][KOG0144:100%*]
Chlamydomonadales@jgi_Volca1_72841[2][RRM3:50%][.RRM2:50%][KOG0144:100%]Trypanosomatidae@XP_827838[2][RRM1:100%][KOG0144:100%]
Cryptosporidium parvum_Iowa_II@XP_628265[RRM2][KOG0144]Volvox carteri@jgi_Volca1_88093[RRM4][KOG1240]
Chlamydomonadales@jgi_Volca1_118581[3][RRM2:67%][.RRM4:33%][KOG0144:67%][.KOG1240:33%]Saccharomycetales@YNL016W[6][RRM3:100%*][put-sr:33%][KOG0148:83%*][.KOG0123:17%]
Embryophyta@30076_m004622[9][RRM1:100%**][FCAFPA:22%][KOG0144:100%**]Arabidopsis thaliana@NP_850472[RRM1][FCAFPA][KOG0144]
Medicago truncatula@IMGA_AC155099_2_2[2][RRM1:100%][KOG0144:100%]Dictyostelium discoideum_AX4@XP_635247[RRM1][KOG0144]
Dictyostelium discoideum_AX4@XP_646268[RRM1][KOG0146]Physcomitrella patens@jgi_Phypa1_1_107590[2][RRM1:100%][KOG0144:100%]
Poaceae@11320_m000014_AZM5_6848[3][RRM1:100%*][KOG0144:100%*]Phaeodactylum tricornutum@jgi_Phatr2_42828[RRM1][KOG0144]
Thalassiosira pseudonana@jgi_Thaps3_261541[RRM1][KOG0144]Cryptosporidium parvum_Iowa_II@XP_628265[RRM1][KOG0144]
Plasmodium falciparum_3D7@XP_001350299[RRM1][KOG0144]Theileria parva_strain_Muguga@XP_766017[RRM1][KOG0144]
Cryptosporidium parvum_Iowa_II@XP_001388078[RRM1][put-sr][KOG0144]Chlamydomonas reinhardtii@jgi_Chlre3_174860[RRM2][KOG1240]
Phytophthora@jgi_Phyra1_1_82644[2][RRM1:100%][KOG0144:100%]Bilateria@ENSXETP00000031370[81][RRM1:100%****][Bruno:42%***][KOG0146:84%****][.KOG0144:16%**]
Coelomata@XP_782270[24][RRM1:100%***][Bruno:42%**][KOG0144:100%***]Rattus norvegicus@ENSRNOP00000053644[RRM1][KOG0117]
Eutheria@ENSCPOP00000011171[3][RRM1:100%*][hnRNP:67%][KOG0117:100%*]Bilateria@ENSGALP00000025475[210][RRM1:100%*****][hnRNP:33%****][KOG0117:100%*****]
Tribolium castaneum@XP_967803[2][RRM1:100%][KOG0117:100%]Eutheria@ENSBTAP00000025092[6][RRM1:100%*][KOG0117:100%*]
Gasterosteus aculeatus@ENSGACP00000025947[RRM1][KOG0117]Aedes aegypti@AAEL015050-PA[2][RRM1:100%][KOG0117:100%]
Anopheles gambiae@AGAP002326-PA[RRM1]Saccharomycetales@NP_984279[4][RRM1:100%*][KOG0921:75%*][.KOG0106:25%]
Plasmodium falciparum_3D7@XP_001348072[RRM1][KOG0144]Trypanosomatidae@XP_001469326[2][RRM4:100%][KOG0123:100%]
Trypanosomatidae@XP_001469222[2][RRM4:100%][KOG0123:100%]Dictyostelium discoideum_AX4@XP_629639[RRM2][KOG0145]
Ricinus communis@30146_m003481[RRM3][KOG0123]rosids@30078_m002213[3][RRM3:100%*][PABP:33%][KOG0123:100%*]
Arabidopsis thaliana@NP_195978[RRM1][KOG0123]Oryza sativa_japonica_cultivar-group@NP_001049727[RRM3][KOG0123]
Dictyostelium discoideum_AX4@XP_001134510[RRM4][KOG0123]Ustilago maydis_521@XP_759458[RRM2][KOG0123]Cryptococcus neoformans_var._neoformans_JEC21@XP_569319[RRM1][KOG0123]
Saccharomycetaceae@XP_001385635[2][RRM2:100%][KOG0131:100%]Yarrowia lipolytica@XP_503979[RRM2][KOG0131]
Eukaryota@jgi_Physo1_1_108557[316][RRM2:91%*****][.RRM1:9%***][PABP:46%****][KOG0123:79%*****][.KOG0131:21%****]Cryptosporidium parvum_Iowa_II@XP_627780[RRM2][KOG0131]
Saccharomyces cerevisiae@YOR319W[RRM2][KOG0131]Volvox carteri@jgi_Volca1_116517[RRM2][KOG1984]
Coelomata@ENSTBEP00000005385[105][RRM2:86%****][.RRM1:14%**][P54nrb:30%***][.PSP1:24%***][.PSF:21%***][KOG0115:100%****]Dictyostelium discoideum_AX4@XP_646802[RRM2][KOG0145]
Leishmania infantum_JPCM5@XP_001467067[2][RRM1:100%][KOG0144:100%]Saccharomycetaceae@XP_451236[2][RRM1:100%][KOG0144:100%]
Saccharomyces cerevisiae@YGR250C[RRM1][KOG0108]Yarrowia lipolytica@XP_500351[RRM3][KOG0123]
Leishmania infantum_JPCM5@XP_001466041[RRM4][KOG0123]
4 - PABP
p54rnb
PSP1
PSF
2 - hnRNP
7 - Bruno
FCA FPA
8 - Bruno
FCA FPA
11 - ELAV
RBMS
1
54 5553 - RBM
15
Fungal SR (ScNp13) ?
Fig. S6
84
73
83
74
95
51
70
58
75
Phytophthora ramorum@jgi Phyra1 1 73884[RRM2][KOG4205]Ricinus communis@28976_m000161[RRM2][KOG4205]
Ascomycota@XP_961230[5][RRM2:100%*][put-sr:20%][KOG4205:100%*]Saccharomycetales@XP_449511[7][RRM2:100%*][KOG4205:100%*]Eukaryota@AGAP006656-PA[121][RRM2:88%****][.RRM1:12%**][Musashi:36%***][.Dazap:21%***][.hnRNP:10%**][KOG4205:100%****]
Ciona@ENSCSAVP00000001921[3][RRM2:100%*][Musashi:67%][KOG4205:100%*]Strongylocentrotus purpuratus@NP_999784[3][RRM1:100%*][KOG4205:100%*]
Cryptosporidium parvum_Iowa_II@XP_001388284[RRM2][KOG4205]Cryptosporidium parvum_Iowa_II@XP_626025[RRM2][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_626579[RRM2][KOG4205]Theileria parva_strain_Muguga@XP_766400[RRM1][put-sr][KOG4205]
Plasmodium falciparum_3D7@XP_001351452[RRM2][KOG4205]Myotis lucifugus@ENSMLUP00000003070[RRM1][hnRNP][KOG4205]
Oryctolagus cuniculus@ENSOCUP00000001170[RRM1][hnRNP][KOG4205]Bacillariophyta@jgi_Phatr2_21039[2][RRM1:100%][KOG4205:100%]
Endopterygota@CG16901-PC[19][RRM1:100%**][KOG4205:100%**]Strongylocentrotus purpuratus@XP_001176409[2][RRM2:100%][KOG4205:100%]
Strongylocentrotus purpuratus@XP_001183095[2][RRM2:100%][KOG4205:100%]Caenorhabditis elegans@F42A6_7a_1[8][RRM2:100%**][KOG4205:100%**]
Coelomata@CG6354-PB[373][RRM2:95%*****][hnRNP:53%*****][KOG4205:100%*****]Sorex araneus@ENSSARP00000008097[RRM2][hnRNP][KOG4205]
Ciona@ENSCINP00000008394[8][RRM2:100%**][KOG4205:100%**]Ciona intestinalis@ENSCINP00000012771[RRM2][put-sr][KOG4205]
Ustilago maydis_521@XP_758567[RRM2][KOG4205]Dictyostelium discoideum_AX4@XP_629598[RRM2][KOG4205]
Cyanidioschyzon merolae@gnl_CMER_CMR392C[RRM2][KOG4205]Ostreococcus tauri@jgi_Ostta4_33731[RRM2]
Ostreococcus tauri@jgi_Ostta4_33731[RRM1]Drosophila melanogaster@CG9654-PA[RRM2][KOG4205]
Caenorhabditis elegans@Y73B6BL_6b_3[10][RRM1:100%**][KOG4205:100%**]Strongylocentrotus purpuratus@XP_798256[2][RRM1:100%][KOG2277:100%]
Oryzias latipes@ENSORLP00000005442[2][RRM1:100%][KOG2277:100%]Xenopus tropicalis@ENSXETP00000012439[RRM1][KOG2277]
Oryctolagus cuniculus@ENSOCUP00000014792[RRM1][KOG2277]Viridiplantae@NP_851001[17][RRM2:100%**][put-sr:12%][KOG4205:94%**][.KOG1833:6%]
Theileria parva_strain_Muguga@XP_766400[RRM2][put-sr][KOG4205]Ostreococcus lucimarinus@jgi_Ost9901_3_24530[RRM1][KOG4205]
Oryza sativa_japonica_cultivar-group@NP_001067093[RRM1][KOG4177]Plasmodium falciparum_3D7@XP_001351452[RRM1][KOG4205]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568675[RRM2][KOG4205]Endopterygota@AAEL008257-PA[8][RRM2:100%**][KOG4205:100%**]
Chlamydomonadales@jgi_Volca1_107445[2][RRM2:100%][KOG4205:100%]Physcomitrella patens@jgi_Phypa1_1_19696[RRM1][KOG4205]
Endopterygota@XP_001121454[19][RRM2:100%**][KOG4205:100%**]Euteleostomi@ENSDARP00000005968[129][RRM2:95%****][.RRM1:5%*][hnRNP:57%****][KOG4205:100%****]
Physcomitrella patens@jgi_Phypa1_1_120016[RRM2][KOG4205]Caenorhabditis elegans@Y73B6BL_6a_3[10][RRM2:100%**][KOG4205:100%**]
Ciona@ENSCSAVP00000016637[3][RRM2:100%*][KOG4205:100%*]Ciona@ENSCINP00000028810[2][RRM2:100%][KOG4205:100%]
Ornithorhynchus anatinus@ENSOANP00000022523[3][RRM1:67%][.RRM2:33%][KOG2248:100%*]Plasmodium falciparum_3D7@XP_001347758[RRM2][KOG0149]
Plasmodium falciparum_3D7@XP_001347758[RRM1][KOG0149]Strongylocentrotus purpuratus@XP_789716[2][RRM2:100%][KOG4205:100%]
Strongylocentrotus purpuratus@XP_780859[2][RRM2:100%][KOG4205:100%]Chlamydomonadales@jgi_Volca1_43575[2][RRM3:100%][KOG4205:100%]
Encephalitozoon cuniculi_GB-M1@NP_597487[RRM1][KOG4205]Embryophyta@IMGA_AC144431_42_2[6][RRM3:100%*][put-sr:17%][KOG4205:100%*]
Embryophyta@jgi_Phypa1_1_112860[6][RRM2:100%*][put-sr:17%][KOG4205:100%*]Chlamydomonadales@jgi_Chlre3_105806[2][RRM2:100%][KOG4205:100%]
Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM2][KOG0123]Eukaryota@XP_391240[27][RRM2:67%**][.RRM1:33%**][cpRNP:19%*][KOG0127:48%**][.KOG0108:22%*][.KOG0131:15%*][.KOG0149:7%][.KOG0145:7%]
Volvox carteri@jgi_Volca1_36996[RRM1][KOG0116]Tribolium castaneum@XP_970765[RRM1][KOG0127]
Ostreococcus@jgi_Ost9901_3_34381[2][RRM1:100%][KOG0145:100%]Aureococcus anophagefferens@jgi_Auran1_9354[RRM1]
Cryptosporidium parvum_Iowa_II@XP_628599[RRM2][KOG4205]Plasmodium falciparum_3D7@XP_001352039[RRM2][KOG0144]
Cryptosporidium parvum_Iowa_II@XP_626158[RRM2][KOG0144]Oryza sativa_japonica_cultivar-group@NP_001045556[RRM1][KOG0108]
rosids@29154_m000213[5][RRM1:100%*][oligoU:40%][KOG0122:40%][.KOG0113:20%][.KOG0148:20%]Magnoliophyta@NP_001052753[3][RRM1:100%*][oligoU:33%][KOG0108:33%][.KOG0149:33%][.KOG0127:33%]
Magnoliophyta@29930_m000611[5][RRM1:100%*][KOG0113:100%*]Magnoliophyta@9946_m000021_AZM5_3995[2][RRM1:100%][KOG0111:50%][.KOG0113:50%]
Arabidopsis thaliana@NP_974808[2][RRM1:100%][KOG0123:50%][.KOG0148:50%]Cryptococcus neoformans_var._neoformans_JEC21@XP_566745[2][RRM1:100%]
Medicago truncatula@IMGA_AC122162_7_2[RRM1][KOG0149]Arabidopsis thaliana@NP_565646[RRM1][KOG0149]
Ricinus communis@30055_m001598[RRM1][KOG0149]Eukaryota@jgi_Phypa1_1_37849[169][RRM1:100%*****][put-sr:5%**][GRSRBP:33%****][.hnRNP:18%***][.RBMY:15%***][KOG0108:23%***][.KOG0111:23%***][.KOG0149:18%***][.KOG0117:11%**][.KOG0116:9%**]
Magnoliophyta@NP_001059075[6][RRM1:100%*][put-sr:17%][GRSRBP:50%*][KOG0108:50%*][.KOG0148:33%][.KOG0111:17%]rosids@NP_568388[3][RRM1:100%*][KOG0125:33%][.KOG0148:33%]
Physcomitrella patens@jgi_Phypa1_1_151460[4][RRM1:100%*][KOG0108:75%*][.KOG0149:25%]Magnoliophyta@NP_181287[9][RRM1:100%**][oligoU:22%][KOG0148:56%*][.KOG0127:22%][.KOG0145:11%][.KOG0113:11%]
Arabidopsis thaliana@NP_173298[RRM1][GRSRBP][KOG0149]Euteleostomi@ENSGALP00000012472[36][RRM4:89%***][.RRM2:8%*][nucleolin:56%**][KOG0123:100%***]
Yarrowia lipolytica@XP_505375[RRM1][KOG0148]Saccharomycetales@XP_456900[6][RRM1:100%*][nucleolin:17%][KOG0148:50%*][.KOG0131:33%][.KOG4210:17%]
Schizosaccharomyces pombe_972h-@NP_593531[RRM1][nucleolin][KOG0147]Basidiomycota@XP_566835[2][RRM1:100%][KOG0148:100%]
Aspergillus fumigatus_Af293@XP_754840[RRM1][KOG0148]Neurospora crassa_OR74A@XP_963862[RRM1][KOG0127]
Cryptosporidium parvum_Iowa_II@XP_626158[RRM1][KOG0144]Embryophyta@29900_m001607[13][RRM2:100%**][oligoU:38%*][KOG4205:77%**][.KOG0149:23%*]
Embryophyta@jgi_Phypa1_1_44443[2][RRM2:100%][KOG0149:100%]Chordata@ENSOGAP00000005376[31][RRM2:90%***][.RRM3:6%][RBM:39%**][KOG0127:100%***]
Tribolium castaneum@XP_974350[RRM1][KOG0127]Apis mellifera@XP_624495[RRM1][KOG0127]
Nasonia vitripennis@XP_001605703[RRM2][KOG0127]Nasonia vitripennis@XP_001605703[RRM1][KOG0127]
Aedes aegypti@AAEL008572-PA[RRM1][KOG0127]Drosophila melanogaster@CG4806-PA[RRM1][KOG0127]
Strongylocentrotus purpuratus@XP_793277[2][RRM3:100%][KOG0117:100%]Bilateria@ENSLAFP00000012959[197][RRM3:93%*****][.RRM2:5%**][hnRNP:36%****][KOG0117:100%*****]
Embryophyta@jgi_Phypa1_1_217831[15][RRM3:93%**][.RRM1:7%][KOG0117:100%**]Embryophyta@29742_m001371[15][RRM2:80%**][.RRM1:20%*][put-sr:87%**][SR:67%**][KOG0106:100%**]
Chlamydomonas reinhardtii@jgi_Chlre3_80366[RRM2][KOG0106]Chlamydomonas reinhardtii@jgi_Chlre3_120019[RRM2][KOG0106]Bacillariophyta@jgi_Phatr2_47737[2][RRM1:100%][put-sr:50%]
Cyanidioschyzon merolae@gnl_CMER_CMO009C[RRM2]Saccharomycetales@XP_455897[3][RRM1:100%*][KOG0123:67%]
Caenorhabditis elegans@C07A4_1[RRM2][KOG0148]Caenorhabditis elegans@Y46G5A_13[10][RRM2:80%**][.RRM3:20%][KOG0148:100%**]
Coelomata@CG4787-PA[102][RRM3:74%****][.RRM2:16%**][.RRM1:11%**][TIATIAR:75%****][KOG0148:100%****]Embryophyta@29727_m000492[13][RRM3:92%**][.RRM2:8%][oligoU:46%*][KOG0148:100%**]
Dikarya@XP_570577[4][RRM3:100%*][KOG0148:100%*]Embryophyta@NP_001067623[8][RRM1:100%**][KOG0117:100%**]
Oryza sativa_japonica_cultivar-group@NP_001066102[RRM1][KOG0117]rosids@NP_001030849[6][RRM1:100%*][KOG0117:100%*]
Physcomitrella patens@jgi_Phypa1_1_140180[3][RRM1:100%*][KOG0117:100%*]Magnoliophyta@29709_m001182[6][RRM1:100%*][put-sr:17%][KOG0117:100%*]
62
79 - TIA TIAR
OligoU
56 - green plant-specific
RS group of SR proteins
63 - hnRNP
71 - RBM
35 - G3BP
RBM
58 - GSRBP
hnRNP
RBMY
34
Fig. S6
85
5158
74
54
70
83
63
76 75
56
61 53
86
55
65 66
99
77
61
95
83
54
Saccharomycetaceae@XP 453677[2][RRM1:100%][KOG4209:100%]Candida glabrata_CBS138@XP_447800[RRM1][KOG4209]
Saccharomyces cerevisiae@YIR001C[RRM1][PABP][KOG4209]Eukaryota@ENSCSAVP00000003369[89][RRM1:100%****][put-sr:17%**][PABP:26%***][KOG4209:100%****]
Dictyostelium discoideum_AX4@XP_642788[RRM1][KOG4209]Caenorhabditis elegans@T08B6_5[RRM1][KOG4209]
Caenorhabditis elegans@EEED8_12[2][RRM1:100%][KOG4209:100%]Ciona@ENSCSAVP00000010162[2][RRM1:100%][KOG4209:100%]
Volvox carteri@jgi_Volca1_103724[RRM1][put-sr][KOG0591]Physcomitrella patens@jgi_Phypa1_1_167236[RRM1][KOG4209]
Arabidopsis thaliana@NP_180012[RRM1]Magnoliophyta@IMGA_AC160842_25_1[6][RRM1:100%*][KOG3702:83%*][.KOG4209:17%]
Aspergillus fumigatus_Af293@XP_755976[RRM1]Sordariomycetes@XP_956776[2][RRM1:100%][put-sr:50%]
Schizosaccharomyces pombe_972h-@NP_595728[RRM1]Ustilago maydis_521@XP_762237[RRM1]
Ostreococcus@jgi_Ost9901_3_31221[2][RRM1:100%][KOG0128:100%]Magnoliophyta@29609_m000574[4][RRM1:100%*][KOG0128:100%*]
Physcomitrella patens@jgi_Phypa1_1_135986[RRM1][KOG0128]Yarrowia lipolytica@XP_504609[RRM1]
Coelomata@XP_001182806[39][RRM1:100%***][KOG0108:13%*][.KOG0116:8%*][.KOG0921:5%]Phytophthora@jgi_Phyra1_1_83430[2][RRM1:100%]
Pichia stipitis_CBS_6054@XP_001384729[RRM1]Ciona@ENSCSAVP00000001842[2][RRM1:100%]Euteleostomi@ENSSARP00000000775[28][RRM1:100%***][eIF4B:54%**]
Anopheles gambiae@AGAP000525-PA[RRM1]Drosophila melanogaster@CG10837-PA[3][RRM1:100%*]
Yarrowia lipolytica@XP_505724[RRM1][KOG4198]Schizosaccharomyces pombe_972h-@NP_595090[RRM2]
Pezizomycotina@XP_961985[2][RRM2:100%][KOG0116:50%]Caenorhabditis elegans@ZC404_8_2[2][RRM1:100%][KOG0125:100%]
Felis catus@ENSFCAP00000007638[RRM1][KOG0125]Bilateria@ENSORLP00000014121[125][RRM1:100%****][FOX:75%****][KOG0125:100%****]
Dictyostelium discoideum_AX4@XP_629578[RRM1][KOG0122]Phytophthora@jgi_Physo1_1_137237[2][RRM1:100%][put-sr:100%][KOG0125:50%][.KOG0148:50%]
Plasmodium falciparum_3D7@XP_001347313[RRM1][KOG0127]Embryophyta@jgi_Phypa1_1_28366[17][RRM1:100%**][put-sr:76%**][KOG0127:29%*][.KOG0125:12%][.KOG4661:6%][.KOG0147:6%]
Coelomata@ENSTBEP00000011040[87][RRM1:98%****][put-sr:16%**][KOG4661:100%****]Tribolium castaneum@XP_971197[RRM1][KOG4661]
Tribolium castaneum@XP_969134[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_570425[RRM1][put-sr][KOG0145]
Yarrowia lipolytica@XP_499712[RRM1][KOG0145]Pezizomycotina@XP_960722[3][RRM1:100%*][put-sr:33%][KOG0113:33%]
Schizosaccharomyces pombe_972h-@NP_001018280[RRM1][KOG0145]Chlamydomonas reinhardtii@jgi_Chlre3_152139[RRM1][KOG0117]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569209[RRM2][KOG0144]Ustilago maydis_521@XP_761797[RRM1][put-sr][KOG3257]Leptospira@YP_001385[4][RRM1:100%*][PROK:100%*]
Oryza sativa_japonica_cultivar-group@NP_001054954[2][RRM1:100%][KOG0108:100%]Chlamydomonas reinhardtii@jgi_Chlre3_194261[RRM1][KOG0123]
Strongylocentrotus purpuratus@XP_793862[2][RRM2:100%][KOG0144:100%]Chlamydomonadales@jgi_Volca1_120471[2][RRM1:100%][KOG0108:100%]
Encephalitozoon cuniculi_GB-M1@NP_586226[RRM1][put-sr][KOG0123]Amniota@ENSMODP00000004174[11][RRM4:55%*][.RRM3:36%*][.RRM2:9%][put-sr:100%**][KOG0112:100%**]
Ciona intestinalis@ENSCINP00000024280[RRM1][KOG0113]Chlamydomonadales@jgi_Volca1_107658[2][RRM1:100%][KOG4205:50%][.KOG0474:50%]
Dictyostelium discoideum_AX4@XP_640243[RRM1][KOG0117]Strongylocentrotus purpuratus@NP_999784[3][RRM2:100%*][KOG4205:100%*]
Ciona@ENSCINP00000009845[4][RRM1:100%*][KOG0116:100%*]Deuterostomia@ENSMODP00000011218[78][RRM1:100%****][G3BP:82%****][KOG0116:100%****]
Apis mellifera@XP_623996[RRM1][KOG0116]Tribolium castaneum@XP_975463[RRM1][KOG0116]
Dictyostelium discoideum_AX4@XP_643377[RRM1][KOG3598]Euteleostomi@ENSEEUP00000005436[64][RRM1:95%****]
Takifugu rubripes@SINFRUP00000155469[RRM1]Coelomata@AAEL001684-PA[39][RRM1:100%***][KOG0125:21%**]
Caenorhabditis elegans@F56D1_7[RRM1]Spermophilus tridecemlineatus@ENSSTOP00000003171[RRM1]
Tupaia belangeri@ENSTBEP00000015084[RRM1]Arabidopsis thaliana@NP_179762[RRM1][oligoU]
Phytophthora@jgi_Phyra1_1_84416[2][RRM1:100%][KOG0148:100%]Phytophthora@jgi_Physo1_1_134615[2][RRM1:100%]
Oryza sativa_japonica_cultivar-group@NP_001051402[RRM1][KOG0149]Zea mays@14684_m000016_AZM5_14964[RRM1][KOG4205]
Dictyostelium discoideum_AX4@XP_643856[3][RRM1:100%*][KOG0149:100%*]Euteleostomi@ENSSTOP00000002923[18][RRM1:100%**][KOG4205:11%]
Caenorhabditis elegans@C50B8_1[RRM1]Strongylocentrotus purpuratus@XP_001188704[2][RRM1:100%][KOG0149:100%]
Diptera@AAEL006645-PA[2][RRM1:100%][KOG0149:100%]Diptera@AAEL008317-PA[3][RRM1:100%*][KOG0149:100%*]
Aureococcus anophagefferens@jgi_Auran1_66158[RRM2][put-sr][KOG0149]Arabidopsis thaliana@NP_187353[RRM1][30kRRM][KOG0149]
Eukaryota@NP_001058102[93][RRM1:100%****][RBM:52%***][.30kRRM:13%**][KOG0149:96%****]Arabidopsis thaliana@NP_200183[2][RRM1:100%][oligoU:100%][KOG0149:100%]
Phytophthora sojae@jgi_Physo1_1_139371[RRM1][KOG4205]Oryza sativa_japonica_cultivar-group@NP_001054022[RRM1][KOG4205]
Magnoliophyta@NP_001042672[10][RRM1:100%**][oligoU:50%*][KOG4205:80%**][.KOG0149:20%]Arabidopsis thaliana@NP_850021[4][RRM1:100%*][oligoU:100%*][KOG0149:75%*][.KOG2186:25%]
Aureococcus anophagefferens@jgi_Auran1_6078[RRM1][KOG4205]Aureococcus anophagefferens@jgi_Auran1_9576[RRM1][KOG0149]
Phytophthora ramorum@jgi_Phyra1_1_73884[RRM1][KOG4205]Ciona intestinalis@ENSCINP00000006182[RRM1][KOG4205]
Ciona intestinalis@ENSCINP00000029053[RRM1][KOG4205]Eukaryota@ENSMODP00000031317[289][RRM1:100%*****][hnRNP:28%****][.Musashi:13%***][.Dazap:9%***][KOG4205:99%*****]
Bilateria@ENSRNOP00000022054[326][RRM1:100%*****][hnRNP:54%*****][KOG4205:100%*****]Strongylocentrotus purpuratus@XP_001189292[2][RRM1:100%][KOG4205:100%]
Strongylocentrotus purpuratus@XP_001176409[2][RRM1:100%][KOG4205:100%]Chlamydomonadales@jgi_Chlre3_105806[2][RRM1:100%][KOG4205:100%]
Coelomata@SINFRUP00000146060[58][RRM1:100%****][TARDBP:72%***][KOG4205:98%****]Strongylocentrotus purpuratus@XP_789716[2][RRM1:100%][KOG4205:100%]
Cyanidioschyzon merolae@gnl_CMER_CMR392C[RRM1][KOG4205]Chlamydomonadales@jgi_Volca1_107445[2][RRM1:100%][KOG4205:100%]
Phaeodactylum tricornutum@jgi_Phatr2_41450[RRM1][KOG4205]Thalassiosira pseudonana@jgi_Thaps3_25203[2][RRM1:100%][KOG4205:100%]Embryophyta@jgi_Phypa1_1_156290[6][RRM1:100%*][put-sr:17%][KOG4205:100%*]
Phaeodactylum tricornutum@jgi_Phatr2_21039[RRM2][KOG4205]Ciona@ENSCINP00000012771[9][RRM1:100%**][put-sr:11%][KOG4205:100%**]
Oryza sativa_japonica_cultivar-group@NP_001058805[RRM1][KOG4205]Ricinus communis@28976_m000161[RRM1][KOG4205]Ricinus communis@30170_m013671[RRM1][KOG4205]Arabidopsis thaliana@NP_176143[RRM1][KOG4205]
Takifugu rubripes@SINFRUP00000163373[RRM1][KOG0149]Takifugu rubripes@SINFRUP00000145256[RRM1][KOG0149]
Plasmodium falciparum_3D7@XP_001352039[RRM1][KOG0144]Cryptosporidium parvum_Iowa_II@XP_628599[RRM1][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_626025[RRM1][KOG4205]Chlamydomonadales@jgi_Chlre3_181880[2][RRM2:100%][KOG4205:100%]Cryptosporidium parvum_Iowa_II@XP_001388284[RRM1][KOG4205]
Drosophila melanogaster@CG9654-PA[RRM1][KOG4205]Phytophthora ramorum@jgi_Phyra1_1_73884[RRM2][KOG4205]
30K-RRM
hnRNP
Musashi
Dazap
TARDBP
OligoU
61
68 - FOX
87 - eIF-4B
74
83 - PABP
Fig. S6
86
63 88
84
58
64
59
52
76
52
86
75
58
Tetraodontidae@GSTENP00014994001[2][RRM1:50%][ RRM3:50%][KOG0123:50%]Embryophyta@jgi_Phypa1_1_201182[6][RRM2:100%*][KOG0127:100%*]
Ostreococcus@jgi_Ost9901_3_26255[2][RRM2:100%][KOG0127:100%]Chlamydomonas reinhardtii@jgi_Chlre3_186870[RRM2][KOG0127]Leishmania infantum_JPCM5@XP_001466413[RRM3][put-sr][KOG0147]
Trypanosoma brucei_TREU927@XP_951655[RRM3][put-sr][KOG0109]Trypanosoma brucei_TREU927@XP_951655[RRM2][put-sr][KOG0109]
Leishmania infantum_JPCM5@XP_001466413[RRM2][put-sr][KOG0147]Thalassiosira pseudonana@jgi_Thaps3_1374[RRM2][KOG0116]
Aureococcus anophagefferens@jgi_Auran1_8214[RRM1]Phytophthora@jgi_Physo1_1_136329[2][RRM2:100%][KOG0123:100%]
Physcomitrella patens@jgi_Phypa1_1_93324[RRM1]Ustilago maydis_521@XP_761797[RRM2][put-sr][KOG3257]
Dictyostelium discoideum_AX4@XP_638767[RRM2][KOG0123]Phaeodactylum tricornutum@jgi_Phatr2_44442[RRM2][KOG4211]
Physcomitrella patens@jgi_Phypa1_1_96043[RRM1]Physcomitrella patens@jgi_Phypa1_1_204078[RRM1][KOG0116]
Magnoliophyta@NP_001052571[5][RRM1:100%*][KOG0116:100%*]Arabidopsis thaliana@NP_189151[RRM1][NTF][KOG0116]
Phaeodactylum tricornutum@jgi_Phatr2_8457[RRM1][KOG0122]Ostreococcus@jgi_Ostta4_19569[2][RRM3:100%][KOG0127:100%]
Chlamydomonadales@jgi_Volca1_87629[2][RRM3:100%][KOG0127:100%]Dictyostelium discoideum_AX4@XP_646584[RRM3][KOG0127]
Caenorhabditis elegans@B0035_12_2[2][RRM2:100%][KOG0128:100%]Magnoliophyta@30131_m007093[6][RRM3:83%*][.RRM2:17%][KOG0127:100%*]
Physcomitrella patens@jgi_Phypa1_1_201182[RRM3][KOG0127]Theileria parva_strain_Muguga@XP_765501[RRM2][KOG0127]
Saccharomycetales@XP_001385462[7][RRM3:100%*][KOG0127:100%*]Basidiomycota@XP_756663[3][RRM4:67%][.RRM3:33%][KOG0127:100%*]
Schizosaccharomyces pombe_972h-@NP_596114[RRM3][KOG0127]Sordariomycetes@XP_962933[2][RRM3:100%][KOG0127:100%]
Aspergillus fumigatus_Af293@XP_752199[RRM3][KOG0127]Ciona intestinalis@ENSCINP00000018774[2][RRM3:100%][KOG0127:100%]
Caenorhabditis elegans@R05H10_2[RRM2][KOG0127]Oryzias latipes@ENSORLP00000012079[RRM3][KOG0127]
Euteleostomi@ENSGACP00000016696[19][RRM3:79%**][.RRM4:11%][.RRM1:11%][RBM:58%**][KOG0127:100%**]Strongylocentrotus purpuratus@XP_783689[2][RRM2:100%][KOG0127:100%]
Endopterygota@XP_001605703[3][RRM2:67%][.RRM3:33%][KOG0127:100%*]Drosophila melanogaster@CG4806-PA[RRM2][KOG0127]
Aedes aegypti@AAEL008572-PA[RRM2][KOG0127]Schizosaccharomyces pombe_972h-@NP_596518[RRM1][KOG0116]
Yarrowia lipolytica@XP_505184[RRM1]Dictyostelium discoideum_AX4@XP_643642[RRM1][KOG0148]
Ciona intestinalis@ENSCINP00000023563[RRM1][KOG0108]Caenorhabditis elegans@R09B3_3[3][RRM1:100%*][KOG0108:100%*]
Chordata@ENSETEP00000010530[36][RRM1:50%**][.RRM2:50%**][put-sr:100%***][SRrp:75%***][KOG4676:100%***]Saccharomycetaceae@XP_001383390[2][RRM1:100%][KOG0108:100%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572946[RRM1][KOG0108]Oryza sativa_japonica_cultivar-group@NP_001058465[RRM1][KOG0108]
Aureococcus anophagefferens@jgi_Auran1_23269[RRM1][KOG0108]Bacillariophyta@jgi_Phatr2_8451[2][RRM1:100%][KOG0108:100%]
Plasmodium falciparum_3D7@XP_001352196[RRM1][KOG0108]Cryptosporidium parvum_Iowa_II@XP_627975[RRM1][KOG0108]
Eukaryota@ENSDARP00000064611[84][RRM1:100%****][KOG0108:99%****]Encephalitozoon cuniculi_GB-M1@NP_597167[RRM1][KOG0108]
Ostreococcus tauri@jgi_Ostta4_31925[RRM1][KOG0117]Euteleostomi@ENSGACP00000016390[7][RRM1:100%*][put-sr:86%*][RBM:14%][KOG2253:100%*]
Viridiplantae@29631_m001006[3][RRM1:100%*][put-sr:33%][KOG0108:67%][.KOG2253:33%]Ciona savignyi@ENSCSAVP00000008315[4][RRM1:100%*][KOG0108:100%*]
Cryptosporidium parvum_Iowa_II@XP_001388131[RRM1][KOG1015]Theileria parva_strain_Muguga@XP_765374[RRM1]
Physcomitrella patens@jgi_Phypa1_1_12664[RRM1]rosids@30155_m001644[2][RRM1:100%][KOG0116:50%]
Tribolium castaneum@XP_969008[RRM2][KOG0331]Euteleostomi@ENSDARP00000069729[82][RRM1:100%****][KOG1995:77%****][.KOG0921:16%**][.KOG2044:5%*]
Endopterygota@XP_624681[6][RRM1:100%*][put-sr:17%][KOG0921:67%*][.KOG1548:33%]Arabidopsis thaliana@NP_564565[RRM1][put-sr][KOG1995]
Strongylocentrotus purpuratus@XP_001196853[2][RRM1:100%][KOG1995:100%]Ostreococcus tauri@jgi_Ostta4_34258[RRM2]
Thalassiosira pseudonana@jgi_Thaps3_24369[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_44442[RRM1][KOG4211]
Phytophthora@jgi_Phyra1_1_76845[2][RRM1:100%][KOG0123:100%]Phaeodactylum tricornutum@jgi_Phatr2_44395[RRM1]
Poaceae@8373_m000321_c0161G04[2][RRM1:100%][KOG4205:50%][.KOG4211:50%]Volvox carteri@jgi_Volca1_90315[RRM1]
Embryophyta@28180_m000395[3][RRM1:100%*][KOG0124:100%*]Arabidopsis thaliana@NP_191094[RRM1][KOG4205]Ostreococcus tauri@jgi_Ostta4_10328[RRM1][KOG2476]
Phytophthora sojae@jgi_Physo1_1_139998[RRM1]Phytophthora@jgi_Phyra1_1_77488[2][RRM1:100%][KOG4205:100%]
Aureococcus anophagefferens@jgi_Auran1_71372[2][RRM3:50%][.RRM2:50%][put-sr:100%][KOG1178:100%]Caenorhabditis elegans@W02D3_11b[2][RRM1:100%][KOG4211:100%]
Oryzias latipes@ENSORLP00000025180[RRM2][put-sr][KOG4307]Coelomata@ENSCINP00000003632[126][RRM2:70%****][.RRM1:30%***][hnRNP:37%***][.GRSRBP:15%**][KOG4211:100%****]
Danio rerio@ENSDARP00000069459[RRM2][KOG4211]Volvox carteri@jgi_Volca1_117772[RRM1][KOG1365]
Caenorhabditis elegans@Y73B6BL_33[RRM1][KOG4211]Physcomitrella patens@jgi_Phypa1_1_162342[RRM3][KOG1365]
Ciona savignyi@ENSCSAVP00000001587[RRM5][KOG4307]Thalassiosira pseudonana@jgi_Thaps3_5686[RRM2][KOG4211]
Arabidopsis thaliana@NP_188725[RRM2][hnRNP][KOG1365]Plasmodium falciparum_3D7@XP_001347519[RRM1][KOG1365]
Cryptosporidium parvum_Iowa_II@XP_627232[RRM1][put-sr][KOG0105]Cyanidioschyzon merolae@gnl_CMER_CMO334C[RRM2][KOG0126]Trypanosomatidae@XP_827554[2][RRM1:50%][.RRM2:50%][put-sr:50%]
Phaeodactylum tricornutum@jgi_Phatr2_46145[RRM2]Coelomata@ENSDARP00000093407[32][RRM2:88%***][.RRM1:12%*][KOG0108:12%*][.KOG3001:6%][.KOG0123:6%][.KOG0126:6%]
Apis mellifera@XP_394565[RRM2][KOG0147]Volvox carteri@jgi_Volca1_118759[RRM2]
Ostreococcus@jgi_Ostta4_30189[2][RRM1:50%][.RRM2:50%][put-sr:50%]Magnoliophyta@30054_m000807[2][RRM2:100%][KOG1267:50%]
Caenorhabditis elegans@F11A10_7[RRM2][KOG0131]Dictyostelium discoideum_AX4@XP_635997[RRM2]
Theileria parva_strain_Muguga@XP_766096[RRM1]Ascomycota@XP_505055[6][RRM1:83%*][.RRM2:17%]
Drosophila melanogaster@CG12288-PA[RRM2]Culicidae@AGAP003171-PA[3][RRM2:100%*][KOG0148:33%]Phytophthora@jgi_Physo1_1_157186[2][RRM1:100%][KOG0147:100%]
Strongylocentrotus purpuratus@XP_001198098[2][RRM1:100%][put-sr:100%][KOG0147:100%]Ostreococcus@jgi_Ost9901_3_42846[2][RRM1:100%][put-sr:50%][KOG0147:100%]
Volvox carteri@jgi_Volca1_84128[2][RRM1:100%][put-sr:50%][KOG0147:100%]Cryptosporidium parvum_Iowa_II@XP_628665[RRM1][KOG0147]Plasmodium falciparum_3D7@XP_001349956[RRM1][KOG0147]
Dictyostelium discoideum_AX4@XP_638966[RRM1][KOG0147]Eukaryota@ENSMLUP00000011758[47][RRM1:100%***][put-sr:91%***][UMH:64%***][.CAPER:15%*][KOG0147:100%***]
Yarrowia lipolytica@XP_504318[RRM1][KOG0147]Ascomycota@NP_594422[4][RRM1:100%*][put-sr:100%*][KOG0147:100%*]
Trypanosomatidae@XP_001467105[2][RRM1:100%][KOG4209:100%]Trypanosomatidae@XP_847474[2][RRM1:100%]
Saccharomycetaceae@XP_453677[2][RRM1:100%][KOG4209:100%]
75 - CAPER
UMH
80 - hnRNP
85 - SRrp
72 - RBM
Fig. S6
87
72
85 89
83
80
75
86
67
90
63
90
69
Ciona intestinalis@ENSCINP00000019833[3][RRM2:100%*][KOG0128:100%*]Culicidae@AAEL011963-PA[3][RRM2:100%*][KOG0128:100%*]
Strongylocentrotus purpuratus@XP_781643[RRM2][KOG0128]Tribolium castaneum@XP_972538[RRM2][KOG0128]Apocrita@XP_001602582[2][RRM2:100%][KOG0128:100%]
Euteleostomi@ENSOCUP00000014007[29][RRM2:97%***][SART3:69%**][KOG0128:100%***]Apis mellifera@XP_623573[RRM1][KOG0113]
Saccharomycetaceae@XP_001385249[2][RRM1:100%][KOG0113:100%]Saccharomycetales@NP_984033[3][RRM1:100%*][KOG0113:100%*]
Kluyveromyces lactis@XP_452557[RRM1][KOG0113]Yarrowia lipolytica@XP_503802[RRM1][KOG0113]
Embryophyta@29657_m000467[4][RRM1:100%*][put-sr:50%][snRNP:25%][KOG0113:100%*]Ciona@ENSCSAVP00000001345[2][RRM1:100%][KOG0113:100%]
Deuterostomia@XP_001178221[30][RRM1:100%***][put-sr:63%**][snRNP:70%***][KOG0113:100%***]Tribolium castaneum@XP_966565[RRM1][KOG0113]
Phytophthora@jgi_Phyra1_1_44765[2][RRM1:100%][put-sr:50%][KOG0113:100%]Coelomata@AAEL011340-PB[2][RRM1:100%][put-sr:50%][KOG0113:100%]
Rattus norvegicus@ENSRNOP00000048879[RRM1][snRNP][KOG0113]Felis catus@ENSFCAP00000006212[RRM1][put-sr][KOG0113]
Schizosaccharomyces pombe_972h-@NP_593779[RRM1][KOG0113]Sordariomycetes@XP_959061[2][RRM1:100%][KOG0113:100%]
Aspergillus fumigatus_Af293@XP_753306[RRM1][KOG0113]Aureococcus anophagefferens@jgi_Auran1_34517[2][RRM1:100%][put-sr:50%][KOG0113:100%]
Cryptosporidium parvum_Iowa_II@XP_627471[RRM1][KOG0113]Ostreococcus@jgi_Ostta4_11066[2][RRM1:100%][KOG0113:100%]
Eukaryota@jgi_Physo1_1_143842[43][RRM1:100%***][put-sr:47%**][snRNP:14%*][KOG0113:100%***]Ciona intestinalis@ENSCINP00000019832[3][RRM1:100%*][KOG0128:100%*]
Tribolium castaneum@XP_972538[RRM1][KOG0128]Culicidae@AAEL011961-PA[3][RRM1:100%*][KOG0128:100%*]
Apocrita@XP_001602582[2][RRM1:100%][KOG0128:100%]Strongylocentrotus purpuratus@XP_781643[RRM1][KOG0128]
Euteleostomi@ENSSTOP00000002132[31][RRM1:100%***][SART3:68%***][KOG0128:100%***]Ostreococcus tauri@jgi_Ostta4_32569[RRM2]
Aureococcus anophagefferens@jgi_Auran1_64341[RRM2][KOG0108]Phaeodactylum tricornutum@jgi_Phatr2_49387[RRM1]
Ostreococcus lucimarinus@jgi_Ost9901_3_92667[RRM1]Aureococcus anophagefferens@jgi_Auran1_9434[RRM1]
Ostreococcus@jgi_Ostta4_33150[2][RRM2:100%][KOG0108:50%]Embryophyta@28180_m000395[6][RRM2:100%*][KOG0124:50%*][.KOG4205:33%][.KOG4211:17%]
Phytophthora@jgi_Physo1_1_141766[2][RRM2:100%][KOG0148:100%]Magnoliophyta@NP_001053909[5][RRM1:100%*][nucleolin:40%][KOG0123:40%][.KOG4210:40%][.KOG1015:20%]Chlamydomonadales@jgi_Volca1_54847[2][RRM1:100%][KOG0108:100%]
stramenopiles@jgi_Auran1_17857[4][RRM1:50%][.RRM2:50%][KOG0108:50%][.KOG4205:50%]Aedes aegypti@AAEL012119-PA[RRM1]
Kluyveromyces lactis@XP_454447[RRM3][KOG0128]Viridiplantae@jgi_Chlre3_99594[25][RRM1:100%***][KOG0123:8%]
Ostreococcus@jgi_Ost9901_3_7913[3][RRM1:100%*][KOG0131:33%]Trypanosoma brucei_TREU927@XP_829593[RRM1]
Neurospora crassa_OR74A@XP_960450[RRM1]Magnoliophyta@15974_m000013_AZM5_17589[3][RRM2:67%][.RRM1:33%]
Plasmodium falciparum_3D7@XP_966051[RRM2]Ostreococcus lucimarinus@jgi_Ost9901_3_28918[RRM1]
Plasmodium falciparum_3D7@XP_966051[RRM1]Encephalitozoon cuniculi_GB-M1@XP_965888[RRM1][KOG4209]
Pichia stipitis_CBS_6054@XP_001384763[RRM1][KOG0123]Saccharomyces cerevisiae@YMR268C[RRM1][KOG0128]
Trypanosomatidae@XP_843959[2][RRM3:100%]Apocrita@XP_001602363[2][RRM1:100%][KOG1832:50%]
Drosophila melanogaster@CG3594-PA[RRM1][KOG0110]Culicidae@AAEL001997-PA[2][RRM1:100%]
Schizosaccharomyces pombe_972h-@NP_596033[RRM1]Neurospora crassa_OR74A@XP_964518[RRM1]
Sordariomycetes@XP_389032[2][RRM1:100%]Cryptococcus neoformans_var._neoformans_JEC21@XP_570477[RRM1]
Phytophthora@jgi_Physo1_1_136292[2][RRM1:100%]Phaeodactylum tricornutum@jgi_Phatr2_32836[RRM1]
Yarrowia lipolytica@XP_499736[RRM2][KOG4205]Schizosaccharomyces pombe_972h-@NP_594970[RRM2][KOG4210]Saccharomycetales@NP_982813[6][RRM2:100%*][KOG4210:100%*]
Aspergillus fumigatus_Af293@XP_755020[RRM2]Culicidae@AAEL004075-PA[3][RRM5:67%][.RRM1:33%][KOG0110:100%*]Ostreococcus@jgi_Ost9901_3_710[2][RRM4:100%][KOG0110:100%]
Magnoliophyta@NP_193696[2][RRM3:100%][KOG0110:100%]Phytophthora sojae@jgi_Physo1_1_129427[RRM4][KOG0110]
Apocrita@XP_001605134[2][RRM5:100%][KOG0110:100%]Euteleostomi@ENSGALP00000013474[20][RRM5:85%**][.RRM4:5%][.RRM3:5%][.RRM2:5%][put-sr:10%][KOG0110:100%**]
Thalassiosira pseudonana@jgi_Thaps3_268689[RRM4][KOG0110]Phaeodactylum tricornutum@jgi_Phatr2_20740[RRM4][KOG0110]
Cryptosporidium parvum_Iowa_II@XP_627799[RRM4][KOG0110]Cryptococcus neoformans_var._neoformans_JEC21@XP_569873[RRM4][KOG0110]
Ascomycota@XP_001386803[10][RRM4:90%**][.RRM2:10%][KOG0110:100%**]Saccharomycetaceae@XP_458658[2][RRM1:100%][KOG0921:100%]Phytophthora@jgi_Physo1_1_132702[3][RRM1:100%*][KOG0127:100%*]
Plasmodium falciparum_3D7@XP_001352080[RRM2]Ashbya gossypii_ATCC_10895@NP_984845[RRM3][KOG0123]
Kluyveromyces lactis@XP_451368[RRM3][KOG0123]Saccharomyces cerevisiae@YHR015W[RRM3][KOG0123]
Candida glabrata_CBS138@XP_447635[RRM3][KOG0123]Saccharomyces cerevisiae@YFR023W[RRM3][KOG0123]
Saccharomycetales@NP_986417[7][RRM1:100%*][KOG0127:100%*]Basidiomycota@XP_568669[3][RRM1:100%*][KOG0127:100%*]
Schizosaccharomyces pombe_972h-@NP_596114[RRM1][KOG0127]Euteleostomi@ENSOANP00000001262[28][RRM1:100%***][RBM:46%**][KOG0127:100%***]
Sordariomycetes@XP_382687[2][RRM1:100%][KOG0127:100%]Aspergillus fumigatus_Af293@XP_752199[RRM1][KOG0127]
Ostreococcus tauri@jgi_Ostta4_19569[RRM1][KOG0127]Ostreococcus lucimarinus@jgi_Ost9901_3_26255[RRM1][KOG0127]
Ciona@ENSCINP00000018772[3][RRM1:100%*][KOG0127:100%*]Chlamydomonadales@jgi_Chlre3_186870[2][RRM1:100%][KOG0127:100%]
Dictyostelium discoideum_AX4@XP_646584[RRM1][KOG0127]Physcomitrella patens@jgi_Phypa1_1_201182[RRM1][KOG0127]
Magnoliophyta@NP_565513[6][RRM1:100%*][KOG0127:100%*]Physcomitrella patens@jgi_Phypa1_1_188347[RRM2][KOG0123]
Physcomitrella patens@jgi_Phypa1_1_167900[RRM2][KOG1015]Arabidopsis thaliana@NP_188491[RRM2][nucleolin][KOG4210]
Magnoliophyta@29675_m000389[3][RRM2:100%*][KOG0123:67%][.KOG1015:33%]Dikarya@NP_596771[2][RRM1:100%][KOG0108:50%]
Pichia stipitis_CBS_6054@XP_001384763[RRM3][KOG0123]Cryptosporidium parvum_Iowa_II@XP_001388131[RRM2][KOG1015]
Dictyostelium discoideum_AX4@XP_643642[RRM2][KOG0148]Euteleostomi@GSTENP00013801001[29][RRM1:100%***][LA:59%**][KOG1855:100%***]
Euteleostomi@ENSORLP00000006283[2][RRM1:100%][LA:50%][KOG1855:100%]Apocrita@XP_001600355[2][RRM1:100%][KOG1855:100%]
Tribolium castaneum@XP_974730[RRM1][KOG1855]Ciona@ENSCSAVP00000005375[4][RRM2:75%*][.RRM1:25%][KOG0116:75%*][.KOG2141:25%]
Physcomitrella patens@jgi_Phypa1_1_167900[3][RRM1:100%*][KOG0123:33%][.KOG4210:33%][.KOG1015:33%]Euteleostomi@ENSMODP00000021210[32][RRM2:97%***][nucleolin:59%**][KOG0123:100%***]
Ciona@ENSCINP00000008105[4][RRM1:100%*][KOG0116:50%][.KOG2141:25%]Euteleostomi@GSTENP00022906001[41][RRM3:83%***][.RRM2:10%*][.RRM1:7%*][nucleolin:54%***][KOG0123:93%***]
Tetraodontidae@GSTENP00014994001[2][RRM1:50%][.RRM3:50%][KOG0123:50%]
81 - La
70 - RBM
59
73 - SART3
36 - snRNP
37 - SART3
39
Fig. S6
88
7557
62
88
60
56
56
66
60
70
52
73
100
Cryptococcus neoformans var neoformans JEC21@XP 567374[RRM1][KOG0307]Chlamydomonas reinhardtii@jgi_Chlre3_152680[RRM1][KOG4660]
Embryophyta@30128_m008555[15][RRM1:100%**][KOG4660:100%**]Phytophthora ramorum@jgi_Phyra1_1_77702[RRM1][KOG0154]
Trypanosoma brucei_TREU927@XP_845376[RRM3][KOG0148]Volvox carteri@jgi_Volca1_120369[RRM1][put-sr][KOG0147]Schizosaccharomyces pombe_972h-@NP_596424[RRM2][KOG4206]
Pezizomycotina@XP_753458[2][RRM2:100%][put-sr:50%][KOG4206:100%]Plasmodium falciparum_3D7@XP_001349796[RRM2][KOG4206]
Saccharomyces cerevisiae@YBR119W[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_568533[RRM2][KOG4206]
Eukaryota@ENSGACP00000013006[79][RRM2:96%****][snRNP:30%***][KOG4206:100%****]Theileria parva_strain_Muguga@XP_764943[RRM2][KOG4206]
Cryptosporidium parvum_Iowa_II@XP_628165[RRM2][KOG4212]Saccharomycetales@XP_462132[6][RRM1:100%*][KOG0533:100%*]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572037[RRM1][KOG0533]Sordariomycetes@XP_956471[2][RRM1:100%][KOG0533:100%]
Ustilago maydis_521@XP_760032[RRM1][KOG0533]Schizosaccharomyces pombe_972h-@NP_595715[RRM1][KOG0533]
Cyanidioschyzon merolae@gnl_CMER_CMH135C[RRM1]Phytophthora@jgi_Phyra1_1_97175[2][RRM1:100%][put-sr:50%][KOG0533:100%]
Euteleostomi@ENSTBEP00000009485[3][RRM1:100%*][PDIP:33%][KOG0533:33%]Endopterygota@CG6961-PA[7][RRM1:100%*][KOG0533:29%]
Eukaryota@GSTENP00007343001[69][RRM1:100%****][FCAFPA:10%*][KOG0533:99%****]Ostreococcus tauri@jgi_Ostta4_36431[RRM1][KOG0533]
Chlamydomonadales@jgi_Volca1_90392[2][RRM1:100%][KOG0533:100%]Dictyostelium discoideum_AX4@XP_638266[RRM1][KOG0533]
Yarrowia lipolytica@XP_505140[RRM1][KOG0533]Pezizomycotina@XP_958422[3][RRM1:100%*][put-sr:33%][KOG0533:100%*]
Ustilago maydis_521@XP_757147[RRM1][KOG0533]Theileria parva_strain_Muguga@XP_764636[RRM1]
Plasmodium falciparum_3D7@XP_966143[RRM1][KOG0533]Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM3][KOG0123]
Chlamydomonadales@jgi_Volca1_103054[2][RRM3:50%][.RRM2:50%][KOG0055:50%]Trypanosomatidae@XP_001465100[2][RRM2:100%][KOG4212:100%]Saccharomycetales@XP_446962[5][RRM1:100%*][put-sr:60%*][KOG0127:60%*][.KOG0123:40%]
Saccharomycetaceae@XP_462023[2][RRM1:100%][put-sr:100%][KOG0123:100%]Aureococcus anophagefferens@jgi_Auran1_6342[RRM2][KOG0123]
Coelomata@ENSMLUP00000006206[100][RRM2:88%****][.RRM1:12%**][put-sr:5%*][hnRNP:28%***][KOG4212:98%****]Caenorhabditis elegans@C25A1_4_2[2][RRM2:100%][put-sr:100%][KOG4212:100%]
Basidiomycota@XP_758699[7][RRM1:71%*][.RRM2:29%][put-sr:14%][KOG4212:100%*]Plasmodium falciparum_3D7@XP_001347353[RRM2][KOG4212]
Schizosaccharomyces pombe_972h-@NP_594207[RRM2][KOG4212]Pezizomycotina@XP_751108[2][RRM2:100%][put-sr:100%][KOG4212:100%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM2][put-sr][KOG0147]Trypanosomatidae@XP_001465100[2][RRM1:100%][KOG4212:100%]
Yarrowia lipolytica@XP_503927[RRM3][put-sr][KOG4212]Dikarya@XP_568231[5][RRM3:100%*][put-sr:80%*][KOG4212:80%*][.KOG0147:20%]
Saccharomycetales@XP_888678[3][RRM3:67%][.RRM2:33%][put-sr:67%][KOG0123:67%][.KOG4212:33%]Saccharomycetales@YNL004W[4][RRM3:100%*][put-sr:50%][KOG0123:50%][.KOG0127:50%]
Kluyveromyces lactis@XP_453283[RRM2][KOG0123]Saccharomycetales@XP_001386572[3][RRM2:67%][.RRM1:33%][put-sr:67%][KOG0123:67%][.KOG4212:33%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572539[4][RRM2:100%*][KOG4212:100%*]Candida glabrata_CBS138@XP_446962[RRM2][put-sr][KOG0127]
Saccharomycetales@XP_445179[2][RRM2:100%][put-sr:100%][KOG0123:100%]Saccharomycetaceae@XP_453283[2][RRM1:50%][.RRM2:50%][KOG0123:50%][.KOG0127:50%]
Saccharomyces cerevisiae@YNL004W[RRM2][KOG0127]Cyanidioschyzon merolae@gnl_CMER_CMM078C[RRM2][KOG4212]
Chlamydomonadales@jgi_Volca1_78979[2][RRM1:100%][KOG3070:100%]Volvox carteri@jgi_Volca1_109965[RRM2][KOG4212]
Phaeodactylum tricornutum@jgi_Phatr2_51303[RRM2][KOG4212]Phytophthora@jgi_Phyra1_1_75500[2][RRM3:100%][KOG0123:100%]
Thalassiosira pseudonana@jgi_Thaps3_37126[RRM2][KOG0123]Ostreococcus@jgi_Ost9901_3_27365[2][RRM1:100%][KOG0123:50%]
Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM2][KOG4212]Strongylocentrotus purpuratus@XP_786244[2][RRM3:100%][put-sr:100%][KOG4212:100%]
Endopterygota@CG9373-PA[4][RRM3:100%*][KOG4212:100%*]Chordata@ENSOGAP00000002890[91][RRM3:80%****][.RRM2:13%**][.RRM1:7%*][hnRNP:37%***][KOG4212:100%****]
Volvox carteri@jgi_Volca1_103054[RRM2][KOG0055]Bacillariophyta@jgi_Phatr2_7426[2][RRM1:100%]
Chlamydomonadales@jgi_Chlre3_184854[2][RRM1:100%][KOG0055:50%]Eukaryota@jgi_Volca1_109965[18][RRM1:78%**][.RRM2:22%*][put-sr:22%*][KOG4212:61%**][.KOG0123:39%*]
Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM1][KOG4212]Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM1][put-sr][KOG0147]
Strongylocentrotus purpuratus@XP_001187716[4][RRM1:100%*][put-sr:100%*][KOG4212:50%][.KOG4661:50%]Coelomata@ENSOGAP00000009767[86][RRM1:100%****][hnRNP:34%***][KOG4212:100%****]Trypanosoma brucei_TREU927@XP_823301[RRM1][KOG0921]
Bilateria@XP_967263[73][RRM2:78%****][.RRM1:22%**][put-sr:79%****][SR:75%****][KOG0105:100%****]Plasmodium falciparum_3D7@XP_001347501[RRM2][put-sr][KOG0105]
Theileria parva_strain_Muguga@XP_766386[RRM2][put-sr][KOG0105]Phytophthora ramorum@jgi_Phyra1_1_84100[RRM2][KOG0105]
Phytophthora@jgi_Physo1_1_136493[2][RRM2:100%][put-sr:100%][KOG0105:100%]Fungi/Metazoa_group@AGAP004592-PA[123][RRM2:81%****][.RRM1:18%***][put-sr:100%****][SR:60%****][KOG0105:50%****][.KOG0106:46%****]
Theileria parva_strain_Muguga@XP_766728[RRM2][KOG0124]Plasmodium falciparum_3D7@XP_001347332[RRM2][put-sr][KOG0105]
Phaeodactylum tricornutum@jgi_Phatr2_33658[RRM1]Thalassiosira pseudonana@jgi_Thaps3_263845[RRM1][KOG0108]
Aureococcus anophagefferens@jgi_Auran1_17171[RRM1][KOG0108]Anopheles gambiae@AGAP000921-PA[3][RRM1:100%*]
Dictyostelium discoideum_AX4@XP_641688[RRM1][KOG0117]Leishmania infantum_JPCM5@XP_001464648[RRM1][KOG0113]
Arabidopsis thaliana@NP_175125[7][RRM1:43%*][.RRM2:29%][.RRM4:14%][.RRM3:14%][PABP:29%][KOG0123:100%*]Cyanidioschyzon merolae@gnl_CMER_CMT598C[RRM1][KOG0148]
Ciona intestinalis@ENSCINP00000004384[RRM2][KOG0148]Strongylocentrotus purpuratus@XP_001183631[2][RRM2:100%][KOG0148:100%]
Physcomitrella patens@jgi_Phypa1_1_170658[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_13402[RRM1][KOG0226]
Thalassiosira pseudonana@jgi_Thaps3_18991[RRM1][KOG0226]Cryptococcus neoformans_var._neoformans_JEC21@XP_571861[RRM1][KOG0226]
Eukaryota@XP_964958[72][RRM1:100%****][KOG0226:100%****]Nasonia vitripennis@XP_001603091[RRM1][KOG0226]
Eukaryota@IMGA_AC144483_30_2[123][RRM2:83%****][.RRM1:17%***][TIATIAR:58%****][.oligoU:6%*][KOG0148:99%****]Eukaryota@ENSETEP00000015606[204][RRM3:85%*****][.RRM2:11%***][PABP:66%****][KOG0123:100%*****]
Ustilago maydis_521@XP_757329[RRM2][KOG0145]Yarrowia lipolytica@XP_501542[RRM2][KOG0131]
Ciona@ENSCSAVP00000020066[4][RRM1:50%][.RRM2:50%][KOG0131:50%]Saccharomycetales@XP_460477[6][RRM1:67%*][.RRM2:33%][KOG0148:67%*][.KOG3598:17%][.KOG0145:17%]
Saccharomycetales@XP_455748[4][RRM2:100%*][KOG0148:75%*][.KOG0145:25%]Eukaryota@ENSMUSP00000030730[72][RRM2:85%****][.RRM1:15%**][oligoU:10%*][KOG0148:58%***][.KOG0123:25%**][.KOG0131:14%**]
Debaryomyces hansenii_CBS767@XP_461354[RRM2][KOG0148]Pichia stipitis_CBS_6054@XP_001386002[RRM2][KOG0148]
Endopterygota@AAEL011988-PA[5][RRM2:100%*][KOG0144:80%*][.KOG0145:20%]Dictyostelium discoideum_AX4@XP_635179[RRM1][KOG0148]
Aureococcus anophagefferens@jgi_Auran1_28594[RRM2][KOG0148]Ustilago maydis_521@XP_758439[RRM3][KOG0123]
Cryptosporidium parvum_Iowa_II@XP_627799[RRM2][KOG0110]Phytophthora sojae@jgi_Physo1_1_132702[RRM4][KOG0127]
Phytophthora ramorum@jgi_Phyra1_1_79608[2][RRM4:100%][KOG0127:100%]Dictyostelium discoideum_AX4@XP_629950[RRM1][KOG0128]
Ciona intestinalis@ENSCINP00000019833[3][RRM2:100%*][KOG0128:100%*]
>>> RRM2 ofdual-RRM
SR proteins
77 - TIA TIAR
OligoU66 - PaBP
29 - dual-RRM
SR proteins
30 - hnRNP
PDIP
FCA FPA
41 - snRNP
4245
Fig. S6
89
76
67 80
79
81
64
50
50 58
89
99
57
Endopterygota@AGAP002256-PA[4][RRM1:100%*][KOG4454:75%*][ KOG0131:25%]Caenorhabditis elegans@Y37D8A_21_1[2][RRM1:100%][KOG4454:100%]
Cryptosporidium parvum_Iowa_II@XP_627780[RRM1][KOG0131]Plasmodium falciparum_3D7@XP_001348367[RRM1][KOG0131]
Eukaryota@NP_001064759[59][RRM1:100%****][snRNP:8%*][KOG0131:100%****]Saccharomycetaceae@XP_001385635[2][RRM1:100%][KOG0131:100%]
Dictyostelium discoideum_AX4@XP_647248[RRM1][KOG0131]Ashbya gossypii_ATCC_10895@NP_982888[RRM1][KOG0131]
Saccharomyces cerevisiae@YOR319W[RRM1][KOG0131]Candida glabrata_CBS138@XP_447678[RRM1][KOG0131]
Cyanidioschyzon merolae@gnl_CMER_CML202C[RRM1][put-sr]Eukaryota@8925_m000027_AZM5_1178[67][RRM1:100%****][put-sr:84%****][SR:61%***][KOG4207:61%***][.KOG4368:24%**]
Neurospora crassa_OR74A@XP_965346[RRM1][KOG0110]Gammaproteobacteria@YP_113294[2][RRM1:100%][PROK:100%]
Yarrowia lipolytica@XP_500351[RRM2][KOG0123]Encephalitozoon cuniculi_GB-M1@NP_586226[RRM3][put-sr][KOG0123]
Aureococcus anophagefferens@jgi_Auran1_9375[2][RRM1:100%][KOG0122:100%]Aureococcus anophagefferens@jgi_Auran1_17018[RRM1][KOG0111]
Aureococcus anophagefferens@jgi_Auran1_9018[RRM1]Thalassiosira pseudonana@jgi_Thaps3_20266[RRM1][KOG4207]Bacillariophyta@jgi_Thaps3_20223[2][RRM1:100%][KOG0108:100%]
Cryptosporidium parvum_Iowa_II@XP_626081[RRM1][KOG0122]Chlamydomonadales@jgi_Chlre3_184151[2][RRM1:100%][KOG0921:50%][.KOG0116:50%]
Phaeodactylum tricornutum@jgi_Phatr2_8270[RRM1][KOG4207]Phaeodactylum tricornutum@jgi_Phatr2_49481[RRM1][KOG1337]
Aureococcus anophagefferens@jgi_Auran1_17889[RRM1][KOG4207]Theileria parva_strain_Muguga@XP_765374[RRM2]
Yarrowia lipolytica@XP_504884[RRM3][KOG0123]Aedes aegypti@AAEL010807-PA[RRM1][put-sr][KOG1080]
Euteleostomi@ENSORLP00000016244[7][RRM1:100%*][KOG1080:57%*]Leishmania infantum_JPCM5@XP_001468615[RRM1]
Yarrowia lipolytica@XP_503515[RRM1][KOG0122]Saccharomycetaceae@XP_001388004[2][RRM1:100%][KOG0122:100%]Saccharomycetales@XP_446998[3][RRM1:100%*][KOG0122:100%*]
Eukaryota@NP_187747[49][RRM1:100%***][KOG0122:98%***]Medicago truncatula@IMGA_AC144431_18_2[RRM1][KOG0122]
Cryptococcus neoformans_var._neoformans_JEC21@XP_567824[RRM1][KOG0122]Cyanidioschyzon merolae@gnl_CMER_CMH159C[RRM1][KOG0122]
Caenorhabditis elegans@F22B5_2[RRM1][KOG0122]Dictyostelium discoideum_AX4@XP_641693[RRM1][KOG0122]
Apicomplexa@XP_001388056[3][RRM1:100%*][KOG0122:100%*]Bacillariophyta@jgi_Thaps3_19374[2][RRM1:100%][KOG0121:100%]
Cryptosporidium parvum_Iowa_II@XP_627536[RRM1][KOG0121]Encephalitozoon cuniculi_GB-M1@NP_597585[RRM1][KOG0121]
Eukaryota@ENSMODP00000034858[66][RRM1:100%****][KOG0121:100%****]Trypanosomatidae@XP_001466901[2][RRM1:100%][KOG0121:100%]
Theileria parva_strain_Muguga@XP_766484[RRM1][KOG0121]Plasmodium falciparum_3D7@XP_001351463[RRM1][KOG0121]
Thalassiosira pseudonana@jgi_Thaps3_33709[RRM1][KOG0111]Schizosaccharomyces pombe_972h-@NP_595090[RRM1]
Kluyveromyces lactis@XP_453971[RRM1]Saccharomycetales@YHL034C[2][RRM1:100%]
Drosophila melanogaster@CG2050-PA[RRM2]Pichia stipitis_CBS_6054@XP_001387063[RRM1]
Encephalitozoon cuniculi_GB-M1@NP_597583[RRM1][KOG4205]Encephalitozoon cuniculi_GB-M1@NP_597583[RRM2][KOG4205]
Ostreococcus lucimarinus@jgi_Ost9901_3_8174[RRM1][KOG4207]Tribolium castaneum@XP_970765[RRM2][KOG0127]
Ostreococcus@jgi_Ostta4_7793[2][RRM1:100%][KOG0108:100%]Aureococcus anophagefferens@jgi_Auran1_17068[RRM1][KOG4207]
Murinae@ENSMUSP00000078984[3][RRM1:100%*][KOG4207:100%*]Cryptosporidium parvum_Iowa_II@XP_628282[2][RRM1:100%][put-sr:100%][KOG0111:50%][.KOG4207:50%]
Plasmodium falciparum_3D7@XP_001347950[RRM1][KOG4207]Plasmodium falciparum_3D7@XP_001351591[RRM1]
Chlamydomonadales@jgi_Volca1_121229[2][RRM1:100%][put-sr:100%][KOG0415:50%]Phytophthora@jgi_Physo1_1_136528[2][RRM1:100%][put-sr:50%][KOG3208:50%]
Viridiplantae@NP_001046448[23][RRM1:100%***][put-sr:91%***][SR:35%**][KOG4207:13%*][.KOG0127:13%*][.KOG0110:9%]Chordata@ENSETEP00000001114[45][RRM1:100%***][put-sr:96%***][SRrp:82%***][KOG0111:29%**][.KOG0415:13%*]
Phytophthora sojae@jgi_Physo1_1_138511[RRM1][put-sr]Bacillariophyta@jgi_Thaps3_23196[2][RRM1:100%][KOG4207:50%]
Strongylocentrotus purpuratus@XP_001178467[2][RRM1:100%][put-sr:100%]Endopterygota@CG5655-PA[5][RRM1:100%*][put-sr:100%*][KOG0107:80%*][.KOG0921:20%]
Eukaryota@ENSGALP00000022397[157][RRM1:100%*****][put-sr:75%****][SR:59%****][KOG0107:66%****]Strongylocentrotus purpuratus@XP_001180596[2][RRM1:100%][put-sr:100%]
Embryophyta@NP_194280[13][RRM1:100%**][put-sr:77%**][SR:62%**][KOG0106:100%**]Ostreococcus lucimarinus@jgi_Ost9901_3_8794[RRM1][KOG0105]
Plasmodium falciparum_3D7@XP_001351730[RRM1][put-sr][KOG0105]Phytophthora@jgi_Physo1_1_138982[2][RRM1:100%][KOG0105:100%]
Theileria parva_strain_Muguga@XP_766386[RRM1][put-sr][KOG0105]Eukaryota@ENSTBEP00000007356[92][RRM1:100%****][put-sr:82%****][SR:65%****][KOG0105:100%****]
Caenorhabditis elegans@T28D9_2a[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*]Ciona intestinalis@ENSCINP00000016525[RRM1][put-sr][KOG0106]
Aedes aegypti@AAEL012621-PA[RRM1][put-sr][KOG0105]Cavia porcellus@ENSCPOP00000010577[RRM1][put-sr][SR][KOG0106]
Eukaryota@ENSOANP00000021053[127][RRM1:100%****][put-sr:91%****][SR:61%****][KOG0106:55%****][.KOG0105:37%***]Cryptococcus neoformans_var._neoformans_JEC21@XP_567562[RRM1][KOG0106]
Schizosaccharomyces pombe_972h-@NP_594570[RRM1][put-sr][KOG0106]Neurospora crassa_OR74A@XP_960334[RRM1][put-sr][KOG0105]
Phytophthora@jgi_Physo1_1_132702[3][RRM3:100%*][KOG0127:100%*]Embryophyta@28611_m000102[4][RRM2:100%*][put-sr:75%*][KOG0154:100%*]
Embryophyta@jgi_Phypa1_1_161416[4][RRM1:100%*][put-sr:75%*][KOG0154:75%*][.KOG0147:25%]Dictyostelium discoideum_AX4@XP_646990[RRM1][put-sr][KOG0147]
Spermophilus tridecemlineatus@ENSSTOP00000006011[RRM1][put-sr]Eutheria@ENSMLUP00000005283[2][RRM1:100%][put-sr:100%]
Basidiomycota@XP_757472[3][RRM1:100%*][put-sr:33%][KOG0122:33%]Caenorhabditis elegans@C18D11_4_1[2][RRM1:100%][put-sr:100%][KOG0921:100%]
Encephalitozoon cuniculi_GB-M1@NP_585779[RRM1]Dictyostelium discoideum_AX4@XP_642304[RRM1][KOG0415]
Coelomata@AGAP006798-PA[81][RRM1:100%****][put-sr:99%****][KOG0122:26%***][.KOG0125:25%**][.KOG0147:14%**][.KOG0108:9%*]Aedes aegypti@AAEL004293-PA[RRM1][put-sr]
Drosophila melanogaster@CG10128-PC[6][RRM1:100%*][put-sr:100%*]Phytophthora@jgi_Physo1_1_140019[2][RRM1:100%][KOG0116:100%]
Dictyostelium discoideum_AX4@XP_628876[RRM1]Phytophthora@jgi_Phyra1_1_74707[2][RRM3:100%][KOG0110:100%]
Volvox carteri@jgi_Volca1_63158[RRM2][KOG0110]Eukaryota@NP_001053839[55][RRM6:42%***][.RRM5:35%**][.RRM4:11%*][.RRM3:9%*][KOG0110:100%****]
Plasmodium falciparum_3D7@XP_001350574[RRM3][KOG0110]Cryptosporidium parvum_Iowa_II@XP_627799[RRM5][KOG0110]
Encephalitozoon cuniculi_GB-M1@NP_597181[RRM3][KOG0110]Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM5][KOG0110]
Embryophyta@IMGA_AC141435_12_2[17][RRM2:76%**][.RRM1:24%*][KOG4660:100%**]Myotis lucifugus@ENSMLUP00000003020[RRM3][PTBP][KOG1190]
Tetrapoda@ENSXETP00000004736[17][RRM2:59%**][.RRM1:41%*][PTBP:94%**][KOG1190:100%**]Encephalitozoon cuniculi_GB-M1@NP_584580[RRM1][KOG0114]Eukaryota@jgi_Phatr2_8132[54][RRM1:100%***][KOG0114:100%***]
Debaryomyces hansenii_CBS767@XP_458197[RRM1][KOG0114]Schizosaccharomyces pombe_972h-@NP_594609[RRM1][KOG4660]
Dictyostelium discoideum_AX4@XP_645848[RRM1][put-sr]Dictyostelium discoideum_AX4@XP_647083[RRM1]
Cryptococcus neoformans_var._neoformans_JEC21@XP_567374[RRM1][KOG0307]
>>> RRM1 ofSR proteins
44
43
60
16 - dual RRM
SR proteins
17 - single-RRM Zn-K
SR proteins
18
23 - SRrp
22 - single RRM
SR proteins
46
47
22 - single RRM
SR proteinsPROK
24
65
25
Fungal SR (SpSrp2)
Fig. S6
90
0.20
51
51
75
61
66
70
51
63
62
90 99
88
Gammaproteobacteria@YP_561253[27][RRM1:100%***][PROK:100%***][KOG0108:96%***]Geobacter uraniumreducens_Rf4@YP_001230384[RRM1][PROK][KOG0108]
Chlamydomonas reinhardtii@jgi_Chlre3_145376[RRM2]Alkalilimnicola ehrlichei_MLHE-1@YP_741458[RRM1][PROK]
Methanomicrobiales@YP_503016[5][RRM1:100%*][PROK:100%*][KOG0108:40%][.KOG0125:20%][.KOG0116:20%]Treponema pallidum_subsp._pallidum_str._Nichols@NP_218796[RRM1][PROK][KOG0149]
Dictyostelium discoideum_AX4@XP_638767[RRM1][KOG0123]Campylobacter@YP_001467322[2][RRM1:100%][PROK:100%][KOG0148:100%]
Candidatus Protochlamydia_amoebophila_UWE25@YP_007892[RRM1][PROK][KOG0149]Syntrophobacter fumaroxidans_MPOB@YP_845575[RRM1][PROK]
Synechococcus@YP_473618[2][RRM1:100%][PROK:100%][KOG0108:100%]Leptospira@YP_000459[4][RRM1:100%*][PROK:100%*][KOG0108:100%*]
Gammaproteobacteria@YP_001083500[11][RRM1:100%**][PROK:100%**][KOG0145:27%*][.KOG0108:18%][.KOG0144:9%][.KOG0122:9%]Vibrio fischeri_ES114@YP_206444[RRM1][PROK][KOG0145]
Nitrosococcus oceani_ATCC_19707@YP_344746[RRM1][PROK][KOG0148]Bacteroidales@YP_213478[13][RRM1:100%**][PROK:100%**][KOG0108:69%**][.KOG0125:31%*]
Bacteroides@YP_001298723[3][RRM1:100%*][PROK:100%*][KOG0108:100%*]Bacteroidales@YP_001302325[2][RRM1:100%][PROK:100%][KOG0123:50%][.KOG0122:50%]
Syntrophobacter fumaroxidans_MPOB@YP_844222[RRM1][PROK][KOG0108]Ostreococcus tauri@jgi_Ostta4_19468[RRM1][KOG0127]
Ostreococcus@jgi_Ost9901_3_12693[2][RRM2:100%][KOG0127:100%]cellular_organisms@YP_001113853[137][RRM1:100%****][PROK:99%****][KOG0108:58%****][.KOG0116:14%**][.KOG0921:7%**][.KOG0149:7%**][.KOG0111:6%**]
Carboxydothermus hydrogenoformans_Z-2901@YP_359251[RRM1][PROK][KOG0108]Pezizomycotina@XP_962933[3][RRM2:100%*][KOG0127:100%*]
Schizosaccharomyces pombe_972h-@NP_596114[RRM2][KOG0127]Yarrowia lipolytica@XP_499726[RRM2][KOG0127]
Saccharomycetales@XP_459044[4][RRM2:100%*][KOG0127:100%*]Magnoliophyta@NP_001062760[4][RRM1:100%*][KOG0124:50%][.KOG0131:50%]
Ustilago maydis_521@XP_756401[RRM1]Embryophyta@jgi_Phypa1_1_134646[11][RRM1:100%**][cpRNP:9%][KOG0123:45%*][.KOG0127:36%*][.KOG2029:9%]
Magnoliophyta@NP_001058927[3][RRM1:100%*][cpRNP:33%][KOG0131:67%]Magnoliophyta@10511_m000028_AZM5_5258[15][RRM1:100%**][cpRNP:33%*][KOG0127:53%**][.KOG0131:27%*][.KOG0145:13%][.KOG0108:7%]Aureococcus anophagefferens@jgi_Auran1_8994[RRM1][KOG0149]
Magnoliophyta@29333_m001057[3][RRM2:67%][.RRM1:33%][cpRNP:33%][KOG0131:67%][.KOG0148:33%]Magnoliophyta@NP_566958[6][RRM2:67%*][.RRM1:33%][KOG0123:33%][.KOG0124:33%][.KOG0131:33%]
Magnoliophyta@IMGA_AC119413_25_2[4][RRM2:100%*][cpRNP:25%][KOG0127:100%*]Poaceae@19213_m000022_AZM5_85721[2][RRM1:50%][.RRM2:50%][KOG0127:50%]
Ricinus communis@29908_m006094[RRM2][KOG0110]Arabidopsis thaliana@NP_192643[2][RRM2:100%][KOG0110:100%]
Magnoliophyta@NP_001048500[5][RRM2:100%*][cpRNP:20%][KOG0123:100%*]rosids@NP_171616[3][RRM2:100%*][cpRNP:67%][KOG0148:67%][.KOG0110:33%]
Oryza sativa_japonica_cultivar-group@NP_001060859[RRM2][KOG0110]Ostreococcus tauri@jgi_Ostta4_24260[RRM1]
Magnoliophyta@NP_189032[4][RRM1:100%*][put-sr:100%*][KOG0670:100%*]Trypanosomatidae@XP_827855[2][RRM1:100%]
Aureococcus anophagefferens@jgi_Auran1_66158[RRM1][put-sr][KOG0149]Aureococcus anophagefferens@jgi_Auran1_67810[RRM1][put-sr][KOG0120]
Phytophthora@jgi_Phyra1_1_75647[2][RRM1:100%]Neurospora crassa_OR74A@XP_958552[RRM3][KOG0128]
Cyanobacteria@YP_476186[8][RRM1:100%**][PROK:100%**][KOG0108:38%*][.KOG0122:12%]Cyanobacteria@NP_898344[17][RRM1:100%**][PROK:100%**][KOG0108:65%**]Synechococcus_elongatus@YP_399809[2][RRM1:100%][PROK:100%][KOG0108:100%]
Phaeodactylum tricornutum@jgi_Phatr2_16633[RRM1][KOG0125]Magnoliophyta@NP_001060859[5][RRM1:100%*][cpRNP:40%][KOG0110:40%][.KOG0148:40%]
Pelobacter carbinolicus_DSM_2380@YP_357907[RRM1][PROK][KOG0145]Desulfuromonadales@NP_952377[4][RRM1:100%*][PROK:100%*][KOG0108:50%][.KOG0145:25%]
Oryza sativa_japonica_cultivar-group@NP_001053710[RRM1][KOG0127]rosids@30054_m000821[3][RRM1:100%*][cpRNP:33%][KOG0127:100%*]Magnoliophyta@NP_001062073[4][RRM1:100%*][KOG0110:75%*][.KOG0127:25%]
Trypanosoma brucei_TREU927@XP_829716[RRM1]Clupeocephala@ENSORLP00000002364[10][RRM2:100%**][KOG0109:100%**]
Endopterygota@CG7903-PA[5][RRM1:100%*][KOG0109:80%*]Tribolium castaneum@XP_971700[RRM1]
Aedes aegypti@AAEL006876-PA[RRM1][KOG2193]Strongylocentrotus purpuratus@XP_001180991[4][RRM1:100%*]
Xenopus tropicalis@ENSXETP00000056096[RRM1][KOG0109]Mammalia@ENSTBEP00000003150[16][RRM1:100%**][RBM:94%**][KOG0109:100%**]Clupeocephala@ENSGACP00000025151[11][RRM1:100%**][KOG0109:100%**]
Ciona intestinalis@ENSCINP00000023722[RRM1][KOG0109]Ciona intestinalis@ENSCINP00000017840[RRM1][KOG0109]
Euteleostomi@ENSDNOP00000012760[63][RRM2:94%****][.RRM1:6%*][LARK:65%***][.RBM:21%**][KOG0109:97%****]Strongylocentrotus purpuratus@XP_792521[4][RRM1:100%*][put-sr:100%*][KOG0109:100%*]
Coelomata@ENSXETP00000008271[74][RRM1:100%****][LARK:61%***][KOG0109:97%****]Ciona intestinalis@ENSCINP00000017840[RRM2][KOG0109]
Ciona@ENSCSAVP00000017501[2][RRM1:50%][.RRM2:50%][KOG0109:50%]Danio rerio@ENSDARP00000065401[RRM2][KOG0109]
Endopterygota@CG8597-PE[8][RRM2:100%**][LARK:62%*][KOG0109:100%**]Percomorpha@ENSGACP00000007987[5][RRM1:100%*][IGF2BP:80%*][KOG2193:100%*]
Chlamydomonadales@jgi_Volca1_90315[3][RRM2:67%][.RRM3:33%][KOG0123:67%]Neurospora crassa_OR74A@XP_965346[RRM2][KOG0110]
Aspergillus fumigatus_Af293@XP_747328[RRM2][KOG0110]Phytophthora ramorum@jgi_Phyra1_1_76171[2][RRM1:100%][KOG0111:100%]
Phaeodactylum tricornutum@jgi_Phatr2_11308[RRM1][KOG0111]Thalassiosira pseudonana@jgi_Thaps3_31121[RRM1][KOG0111]
Cryptococcus neoformans_var._neoformans_JEC21@XP_566572[RRM1][KOG0111]Schizosaccharomyces pombe_972h-@NP_595190[RRM1][KOG0111]
Pezizomycotina@XP_755630[3][RRM1:100%*][KOG0111:100%*]Theileria parva_strain_Muguga@XP_765867[RRM1][KOG0111]Plasmodium falciparum_3D7@XP_001349948[RRM1][KOG0111]
Eukaryota@ENSGALP00000021793[59][RRM1:100%****][cyclophilin:59%***][KOG0111:98%****]Otolemur garnettii@ENSOGAP00000003225[RRM1][KOG0111]Eutheria@ENSEEUP00000009324[3][RRM1:100%*][cyclophilin:100%*][KOG0111:100%*]
Magnoliophyta@NP_001055607[4][RRM1:100%*][put-sr:25%][KOG0131:100%*]Deuterostomia@ENSXETP00000012868[47][RRM1:100%***][KOG4454:60%***][.KOG0131:40%**]
Drosophila melanogaster@CG11454-PA[RRM1][KOG4454]Endopterygota@AGAP002256-PA[4][RRM1:100%*][KOG4454:75%*][.KOG0131:25%] 47
19 - cyclophilin
51 - LARK
50 - LARK
48 - IGF2BP
49
52
88 - prokaryotic RRMS
prok-3
prok-2
prok-1
Fig. S6
91
76
88
91
69
79
52
62
56
96
91
91
65 50
92
Leishmania infantum JPCM5@XP 001466041[RRM4][KOG0123]Drosophila melanogaster@CG4612-PA[RRM2][KOG0123]
Pezizomycotina@XP_750167[2][RRM4:100%][KOG0123:100%]Eukaryota@ENSDNOP00000002400[249][RRM4:82%*****][.RRM3:11%***][.RRM2:6%**][PABP:54%****][KOG0123:100%*****]
Arabidopsis thaliana@NP_188259[RRM4][PABP][KOG0123]Aedes aegypti@AAEL007013-PA[RRM1][KOG0123]
Ciona@ENSCINP00000018772[3][RRM1:100%*][KOG0127:100%*]Trypanosoma brucei_TREU927@XP_827237[RRM3][KOG0123]
Yarrowia lipolytica@XP_500351[RRM3][KOG0123]Trypanosoma brucei_TREU927@XP_827358[RRM3][KOG0123]
Leishmania infantum_JPCM5@XP_001469222[RRM3][KOG0123]Felis catus@ENSFCAP00000004622[RRM3][PABP][KOG0123]
Caenorhabditis elegans@Y106G6H_2a_4[7][RRM3:71%*][.RRM2:29%][KOG0123:100%*]Caenorhabditis elegans@F18H3_3b[5][RRM3:100%*][KOG0123:100%*]
Dikarya@XP_960425[12][RRM3:100%**][PABP:17%][KOG0123:100%**]Phytophthora@jgi_Physo1_1_108322[2][RRM3:100%][KOG0123:100%]
Thalassiosira pseudonana@jgi_Thaps3_13224[RRM3][KOG0123]Phaeodactylum tricornutum@jgi_Phatr2_23959[RRM3][KOG0123]
Chlamydomonadales@jgi_Volca1_82578[2][RRM3:100%][PABP:100%][KOG0123:100%]Strongylocentrotus purpuratus@XP_001177782[4][RRM3:50%][.RRM2:50%][KOG0123:100%*]
Dictyostelium discoideum_AX4@XP_629007[RRM3][KOG0123]Yarrowia lipolytica@XP_501289[RRM3][KOG0123]
Encephalitozoon cuniculi_GB-M1@NP_586226[RRM3][put-sr][KOG0123]Volvox carteri@jgi_Volca1_36996[RRM1][KOG0116]
Ostreococcus@jgi_Ost9901_3_34381[2][RRM1:100%][KOG0145:100%]Culicidae@AAEL001131-PA[2][RRM1:100%][KOG0113:100%]
Anopheles gambiae@AGAP000921-PA[3][RRM1:100%*]Viridiplantae@29631_m001006[3][RRM1:100%*][put-sr:33%][KOG0108:67%][.KOG2253:33%]
Euteleostomi@ENSGACP00000016390[7][RRM1:100%*][put-sr:86%*][RBM:14%][KOG2253:100%*]Ciona@ENSCSAVP00000015853[4][RRM2:100%*][KOG0145:100%*]
Dictyostelium discoideum_AX4@XP_629639[RRM2][KOG0145]Diptera@AGAP003899-PA[15][RRM2:100%**][KOG0145:100%**]Bilateria@CG3151-PE[218][RRM2:92%*****][.RRM1:7%**][ELAV:84%*****][KOG0145:100%*****]
Coelomata@ENSORLP00000004891[62][RRM2:94%****][.RRM1:6%*][RBMS:79%***][KOG0145:100%****]Ustilago maydis_521@XP_759141[RRM2][KOG0145]
Trypanosomatidae@XP_001468777[2][RRM2:100%][KOG0144:100%]Dictyostelium discoideum_AX4@XP_644081[RRM2][KOG0123]Trypanosomatidae@XP_847495[2][RRM1:100%][KOG0110:50%][.KOG0127:50%]
Trypanosoma brucei_TREU927@XP_843985[3][RRM1:100%*][put-sr:33%][KOG0110:100%*]Leishmania infantum_JPCM5@XP_001466665[RRM1][KOG0110]
Leishmania infantum_JPCM5@XP_001466659[RRM1][KOG0145]Leishmania infantum_JPCM5@XP_001466666[RRM1][KOG0145]
Leishmania infantum_JPCM5@XP_001464836[RRM1][KOG0145]Leishmania infantum_JPCM5@XP_001464835[2][RRM1:100%][KOG0145:100%]
Ciona@ENSCINP00000023191[4][RRM3:75%*][.RRM1:25%][KOG0145:100%*]Coelomata@ENSTBEP00000015452[229][RRM3:88%*****][.RRM2:9%**][ELAV:82%*****][KOG0145:100%*****]
Dictyostelium discoideum_AX4@XP_635793[RRM3][KOG0145]Caenorhabditis elegans@F35H8_5[RRM3][KOG0145]
Encephalitozoon cuniculi_GB-M1@NP_584552[RRM1][KOG0123]Theileria parva_strain_Muguga@XP_766466[RRM3][KOG0123]
Plasmodium falciparum_3D7@XP_001350640[RRM3][KOG0123]Pezizomycotina@XP_387225[3][RRM1:67%][.RRM2:33%][put-sr:100%*][KOG0120:100%*]
Yarrowia lipolytica@XP_503754[RRM1][KOG0120]Schizosaccharomyces pombe_972h-@NP_595396[RRM1][put-sr][KOG0120]
Plasmodium falciparum_3D7@XP_001348830[RRM2][put-sr][KOG0120]Chlamydomonadales@jgi_Volca1_48801[2][RRM1:100%][KOG0120:100%]
Eukaryota@jgi_Volca1_82970[75][RRM2:91%****][.RRM1:9%*][put-sr:80%****][snRNP:53%***][KOG0120:100%****]Phaeodactylum tricornutum@jgi_Phatr2_11145[RRM2][KOG0120]
Dictyostelium discoideum_AX4@XP_635793[RRM1][KOG0145]Dictyostelium discoideum_AX4@XP_635793[RRM2][KOG0145]
Dictyostelium discoideum_AX4@XP_646802[RRM1][KOG0145]Dictyostelium discoideum_AX4@XP_644081[RRM1][KOG0123]
Bilateria@ENSORLP00000021434[219][RRM1:100%*****][ELAV:79%*****][KOG0145:100%*****]Dictyostelium discoideum_AX4@XP_629639[RRM1][KOG0145]
Euteleostomi@ENSXETP00000044031[49][RRM2:76%***][.RRM1:24%**][KOG0145:41%**][.KOG0123:14%*][.KOG0110:14%*]Ciona@ENSCSAVP00000018820[2][RRM2:100%][KOG0145:100%]
Diptera@AAEL011150-PA[15][RRM1:100%**][KOG0145:100%**]Drosophila melanogaster@CG5213-PA[RRM1][KOG0145]
Trypanosomatidae@XP_828145[5][RRM1:100%*][KOG0145:100%*]Trypanosoma brucei_TREU927@XP_845996[RRM1][KOG0122]
Trypanosomatidae@XP_843886[2][RRM1:100%][KOG0145:100%]Dictyostelium discoideum_AX4@XP_644081[RRM3][KOG0123]
Trypanosomatidae@XP_829274[2][RRM1:100%][KOG0145:50%]Leishmania infantum_JPCM5@XP_001463468[RRM1]
Trypanosoma brucei_TREU927@XP_829272[RRM1][KOG0145]Leishmania infantum_JPCM5@XP_001463465[RRM1][KOG0122]
Trypanosomatidae@XP_847111[2][RRM1:100%]Leishmania infantum_JPCM5@XP_001465764[RRM1]
Trypanosoma brucei_TREU927@XP_846161[RRM2]Trypanosoma brucei_TREU927@XP_846161[RRM1]
Leishmania infantum_JPCM5@XP_001463160[RRM2][put-sr]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM5][KOG0123]
Volvox carteri@jgi_Volca1_84128[RRM2][KOG0147]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM4][KOG0123]
Embryophyta@jgi_Phypa1_1_189930[7][RRM1:100%*][KOG0119:86%*][.KOG0307:14%]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM6][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM1][KOG0123]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM3][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM2][KOG0123]Bilateria@ENSORLP00000004891[130][RRM1:100%****][RBMS:72%****][KOG0145:99%****]
Leishmania infantum_JPCM5@XP_001467067[2][RRM1:100%][KOG0144:100%]Dictyostelium discoideum_AX4@XP_638767[RRM2][KOG0123]
Eukaryota@ENSOANP00000006980[251][RRM3:67%*****][.RRM2:24%****][.RRM1:10%***][Bruno:50%****][KOG0144:55%****][.KOG0146:45%****]Aconoidasida@XP_001349292[3][RRM2:100%*][KOG0146:67%][.KOG0144:33%]
Plasmodium falciparum_3D7@XP_001350320[RRM3][KOG0123]Plasmodium falciparum_3D7@XP_001350320[RRM2][KOG0123]
Theileria parva_strain_Muguga@XP_766017[RRM3][KOG0144]Cryptosporidium parvum_Iowa_II@XP_001388078[RRM3][put-sr][KOG0144]
Volvox carteri@jgi_Volca1_106063[RRM2]Dictyostelium discoideum_AX4@XP_636266[RRM3][KOG3598]
9 - bruno
10 - ELAV
64 - snRNP
12 - ELAV
11 - ELAV
RBMS
5 - PABP
6 - PABP
Fig. S7
92
91
51
51
99
78
83
61
59
93
87
70 79
100
52
85
50
56
Phytophthora ramorum@jgi Phyra1 1 77702[RRM1][KOG0154]Embryophyta@28611_m000102[4][RRM2:100%*][put-sr:75%*][KOG0154:100%*]
Chlamydomonas reinhardtii@jgi_Chlre3_145376[RRM2]Saccharomycetaceae@XP_451236[2][RRM1:100%][KOG0144:100%]
Saccharomyces cerevisiae@YGR250C[RRM1][KOG0108]Nasonia vitripennis@XP_001604889[RRM2][KOG0144]
Dictyostelium discoideum_AX4@XP_636266[RRM1][KOG3598]Endopterygota@CG1316-PA[5][RRM1:100%*][KOG0144:80%*][.KOG0148:20%]
Euteleostomi@ENSDNOP00000001522[23][RRM1:100%***][RBM:61%**][KOG0144:87%**][.KOG0145:13%*]Strongylocentrotus purpuratus@XP_001199679[4][RRM1:100%*][KOG0145:50%]
Arabidopsis thaliana@NP_974808[2][RRM1:100%][KOG0123:50%][.KOG0148:50%]Magnoliophyta@NP_181287[9][RRM1:100%**][oligoU:22%][KOG0148:56%*][.KOG0127:22%][.KOG0145:11%][.KOG0113:11%]
Arabidopsis thaliana@NP_173298[RRM1][GRSRBP][KOG0149]rosids@29154_m000213[5][RRM1:100%*][oligoU:40%][KOG0122:40%][.KOG0113:20%][.KOG0148:20%]
Magnoliophyta@NP_001052753[3][RRM1:100%*][oligoU:33%][KOG0108:33%][.KOG0149:33%][.KOG0127:33%]Magnoliophyta@9946_m000021_AZM5_3995[2][RRM1:100%][KOG0111:50%][.KOG0113:50%]Magnoliophyta@29930_m000611[5][RRM1:100%*][KOG0113:100%*]
Medicago truncatula@IMGA_AC122162_7_2[RRM1][KOG0149]Ricinus communis@30055_m001598[RRM1][KOG0149]
Arabidopsis thaliana@NP_565646[RRM1][KOG0149]Tribolium castaneum@XP_967803[2][RRM1:100%][KOG0117:100%]
Rattus norvegicus@ENSRNOP00000053644[RRM1][KOG0117]Eutheria@ENSCPOP00000011171[3][RRM1:100%*][hnRNP:67%][KOG0117:100%*]Bilateria@ENSGALP00000025475[210][RRM1:100%*****][hnRNP:33%****][KOG0117:100%*****]
Eutheria@ENSBTAP00000025092[6][RRM1:100%*][KOG0117:100%*]Gasterosteus aculeatus@ENSGACP00000025947[RRM1][KOG0117]
Anopheles gambiae@AGAP002326-PA[RRM1]Aedes aegypti@AAEL015050-PA[2][RRM1:100%][KOG0117:100%]
Embryophyta@29727_m000492[13][RRM3:92%**][.RRM2:8%][oligoU:46%*][KOG0148:100%**]Saccharomycetales@YNL016W[6][RRM3:100%*][put-sr:33%][KOG0148:83%*][.KOG0123:17%]
Dikarya@XP_570577[4][RRM3:100%*][KOG0148:100%*]Embryophyta@NP_001067623[8][RRM1:100%**][KOG0117:100%**]
rosids@NP_001030849[6][RRM1:100%*][KOG0117:100%*]Oryza sativa_japonica_cultivar-group@NP_001066102[RRM1][KOG0117]
Caenorhabditis elegans@C07A4_1[RRM2][KOG0148]Coelomata@CG4787-PA[102][RRM3:74%****][.RRM2:16%**][.RRM1:11%**][TIATIAR:75%****][KOG0148:100%****]
Caenorhabditis elegans@Y46G5A_13[10][RRM2:80%**][.RRM3:20%][KOG0148:100%**]Aconoidasida@XP_766017[2][RRM2:100%][KOG0144:100%]
Plasmodium falciparum_3D7@XP_001348269[RRM2][KOG0144]Cryptosporidium parvum_Iowa_II@XP_001388078[RRM2][put-sr][KOG0144]
Chlamydomonadales@jgi_Chlre3_99329[2][RRM1:50%][.RRM2:50%][KOG0144:100%]Trypanosoma brucei_TREU927@XP_845376[RRM3][KOG0148]
Thalassiosira pseudonana@jgi_Thaps3_261541[RRM2][KOG0144]Phytophthora@jgi_Physo1_1_140019[2][RRM1:100%][KOG0116:100%]
Chlamydomonas reinhardtii@jgi_Chlre3_174860[RRM2][KOG1240]Dictyostelium discoideum_AX4@XP_646268[RRM2][KOG0146]
Phytophthora sojae@jgi_Physo1_1_139371[RRM2][KOG4205]Cryptosporidium parvum_Iowa_II@XP_628265[RRM2][KOG0144]
Embryophyta@29889_m003323[11][RRM2:100%**][FCAFPA:18%][KOG0144:100%**]Arabidopsis thaliana@NP_850472[RRM2][FCAFPA][KOG0144]
Phytophthora@jgi_Physo1_1_133760[2][RRM2:100%][KOG0144:100%]Embryophyta@jgi_Phypa1_1_115029[9][RRM2:100%**][KOG0144:100%**]Bilateria@AGAP009477-PA[250][RRM2:73%*****][.RRM1:27%****][Bruno:59%****][KOG0144:56%****][.KOG0146:44%****]
Dictyostelium discoideum_AX4@XP_635247[RRM2][KOG0144]Dictyostelium discoideum_AX4@XP_646268[RRM1][KOG0146]
Dictyostelium discoideum_AX4@XP_635247[RRM1][KOG0144]Poaceae@11320_m000014_AZM5_6848[3][RRM1:100%*][KOG0144:100%*]
Physcomitrella patens@jgi_Phypa1_1_107590[2][RRM1:100%][KOG0144:100%]Cryptosporidium parvum_Iowa_II@XP_628265[RRM1][KOG0144]
Plasmodium falciparum_3D7@XP_001348072[RRM1][KOG0144]Theileria parva_strain_Muguga@XP_765501[RRM2][KOG0127]
Takifugu rubripes@SINFRUP00000134535[RRM1][KOG0123]Trypanosomatidae@XP_845656[2][RRM1:100%][KOG0131:50%]
Trypanosomatidae@XP_001468238[3][RRM1:100%*][KOG0144:100%*]Leishmania infantum_JPCM5@XP_001468236[RRM1]
Trypanosomatidae@XP_827838[2][RRM1:100%][KOG0144:100%]Embryophyta@30076_m004622[9][RRM1:100%**][FCAFPA:22%][KOG0144:100%**]
Medicago truncatula@IMGA_AC155099_2_2[2][RRM1:100%][KOG0144:100%]Arabidopsis thaliana@NP_850472[RRM1][FCAFPA][KOG0144]
Chlamydomonadales@jgi_Volca1_72841[2][RRM3:50%][.RRM2:50%][KOG0144:100%]Chlamydomonadales@jgi_Volca1_118581[3][RRM2:67%][.RRM4:33%][KOG0144:67%][.KOG1240:33%]
Volvox carteri@jgi_Volca1_88093[RRM4][KOG1240]Chlamydomonadales@jgi_Volca1_88093[2][RRM1:100%][KOG1240:100%]
Cryptosporidium parvum_Iowa_II@XP_001388078[RRM1][put-sr][KOG0144]Theileria parva_strain_Muguga@XP_766017[RRM1][KOG0144]
Plasmodium falciparum_3D7@XP_001350299[RRM1][KOG0144]Phytophthora@jgi_Phyra1_1_82644[2][RRM1:100%][KOG0144:100%]
Coelomata@XP_782270[24][RRM1:100%***][Bruno:42%**][KOG0144:100%***]Bilateria@ENSXETP00000031370[81][RRM1:100%****][Bruno:42%***][KOG0146:84%****][.KOG0144:16%**]
Thalassiosira pseudonana@jgi_Thaps3_261541[RRM1][KOG0144]Phaeodactylum tricornutum@jgi_Phatr2_42828[RRM1][KOG0144]
Echinops telfairi@ENSETEP00000008100[RRM3][PABP][KOG0123]Trypanosomatidae@XP_827358[2][RRM2:100%][KOG0123:100%]
Saccharomycetales@NP_984279[4][RRM1:100%*][KOG0921:75%*][.KOG0106:25%]Trypanosomatidae@XP_001469326[2][RRM4:100%][KOG0123:100%]
Trypanosomatidae@XP_001469222[2][RRM4:100%][KOG0123:100%]Ricinus communis@30146_m003481[RRM3][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001049727[RRM3][KOG0123]rosids@30078_m002213[3][RRM3:100%*][PABP:33%][KOG0123:100%*]
Arabidopsis thaliana@NP_195978[RRM1][KOG0123]Ustilago maydis_521@XP_759458[RRM2][KOG0123]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569319[RRM1][KOG0123]Saccharomycetaceae@XP_001385635[2][RRM2:100%][KOG0131:100%]
Yarrowia lipolytica@XP_503979[RRM2][KOG0131]Eukaryota@jgi_Physo1_1_108557[316][RRM2:91%*****][.RRM1:9%***][PABP:46%****][KOG0123:79%*****][.KOG0131:21%****]
Cryptosporidium parvum_Iowa_II@XP_627780[RRM2][KOG0131]Schizosaccharomyces pombe_972h-@NP_001018242[RRM3][KOG0123]
Schizosaccharomyces pombe_972h-@NP_593427[RRM2][KOG0123]Leishmania infantum_JPCM5@XP_001466041[RRM2][KOG0123]
Encephalitozoon cuniculi_GB-M1@NP_586226[RRM2][put-sr][KOG0123]Arabidopsis thaliana@NP_174676[RRM1][PABP][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001049727[RRM2][KOG0123]rosids@30146_m003481[2][RRM2:100%][PABP:50%][KOG0123:100%]
rosids@30078_m002213[3][RRM2:100%*][PABP:33%][KOG0123:100%*]Cryptosporidium parvum_Iowa_II@XP_626158[RRM1][KOG0144]
Dikarya@NP_596771[2][RRM1:100%][KOG0108:50%]Dictyostelium discoideum_AX4@XP_646990[RRM1][put-sr][KOG0147]
Caenorhabditis elegans@T23F6_4_1[2][RRM1:100%][KOG0110:100%]Euteleostomi@GSTENP00029551001[21][RRM1:100%***][put-sr:10%][KOG0110:100%***]
Culicidae@AGAP005249-PA[2][RRM1:100%][KOG0110:100%]Apocrita@XP_624611[2][RRM1:100%][KOG0110:100%]
Drosophila melanogaster@CG3335-PA[RRM1][KOG0110]Schizosaccharomyces pombe_972h-@NP_595599[RRM1][KOG0110]
Arabidopsis thaliana@NP_196191[RRM1][KOG0110]Viridiplantae@jgi_Phypa1_1_207810[3][RRM1:100%*][KOG0110:100%*]
Dictyostelium discoideum_AX4@XP_638463[RRM1][KOG0110]Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM1][KOG0110]Saccharomycetaceae@XP_001386803[2][RRM1:100%][KOG0110:100%]
Ustilago maydis_521@XP_758493[RRM1][KOG0110]Leishmania infantum_JPCM5@XP_001466041[RRM4][KOG0123] 15
1
4 - PABP
p54nrb
PSP1
PSF
7 - Bruno
FCA FPA
8 - bruno
FCA FPA
2 - hnRNP
Fungal SR (ScNp13) ?
Fig. S7
93
68 51
81
69 95
91
54
55
77
60
55
73 94
68
80
62
86
Strongylocentrotus purpuratus@XP 001185821[2][RRM1:100%][KOG0670:100%]Pichia stipitis_CBS_6054@XP_001384462[RRM2]
Debaryomyces hansenii_CBS767@XP_460517[RRM2][KOG0117]Saccharomycetales@XP_445844[3][RRM2:100%*][KOG0123:33%]Kluyveromyces lactis@XP_455897[RRM2][KOG0123]
Euteleostomi@ENSOANP00000024755[113][RRM1:100%****][hnRNP:36%***][.RALYL:15%**]Apocrita@XP_623710[2][RRM1:100%]
Physcomitrella patens@jgi_Phypa1_1_204078[RRM1][KOG0116]Magnoliophyta@NP_001052571[5][RRM1:100%*][KOG0116:100%*]Arabidopsis thaliana@NP_189151[RRM1][NTF][KOG0116]
Tribolium castaneum@XP_969873[RRM1]Anopheles gambiae@AGAP007689-PA[RRM1]
Aedes aegypti@AAEL010101-PA[RRM1]Ustilago maydis_521@XP_757329[RRM1][KOG0145]
Trypanosoma brucei_TREU927@XP_829593[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_570577[RRM1][KOG0148]
Embryophyta@NP_188026[13][RRM1:100%**][oligoU:38%*][KOG0148:100%**]Bilateria@ENSSARP00000011721[82][RRM1:100%****][TIATIAR:80%****][KOG0148:100%****]
Saccharomycetales@XP_454345[4][RRM1:100%*][KOG0148:75%*][.KOG0123:25%]Sordariomycetes@XP_385593[2][RRM1:100%][KOG0148:100%]
Saccharomycetaceae@XP_001383142[2][RRM1:100%][put-sr:100%][KOG0148:100%]Yarrowia lipolytica@XP_501542[RRM1][KOG0131]
Chordata@ENSETEP00000010530[36][RRM1:50%**][.RRM2:50%**][put-sr:100%***][SRrp:75%***][KOG4676:100%***]Viridiplantae@jgi_Chlre3_99594[25][RRM1:100%***][KOG0123:8%]
Ostreococcus lucimarinus@jgi_Ost9901_3_28918[RRM1]Magnoliophyta@15974_m000013_AZM5_17589[3][RRM2:67%][.RRM1:33%]
Plasmodium falciparum_3D7@XP_966051[RRM2]Neurospora crassa_OR74A@XP_960450[RRM1]
Volvox carteri@jgi_Volca1_107013[RRM3][KOG0117]Cryptosporidium parvum_Iowa_II@XP_001388334[RRM3][KOG0123]
Dictyostelium discoideum_AX4@XP_635179[RRM2][KOG0148]Embryophyta@jgi_Phypa1_1_140180[4][RRM3:100%*][KOG0117:100%*]
Trypanosoma brucei_TREU927@XP_844190[RRM1][KOG0144]Schizosaccharomyces pombe_972h-@NP_588373[RRM1]
Dictyostelium discoideum_AX4@XP_644288[RRM2][KOG3598]Schizosaccharomyces pombe_972h-@NP_595389[RRM1][KOG4574]
Yarrowia lipolytica@XP_500252[RRM1][KOG4574]Neurospora crassa_OR74A@XP_962915[RRM1][KOG4574]
Cryptococcus neoformans_var._neoformans_JEC21@XP_570411[RRM2][KOG4574]Clupeocephala@ENSORLP00000009616[3][RRM1:100%*][KOG0548:100%*]
Strongylocentrotus purpuratus@XP_001188888[2][RRM1:100%][KOG0548:100%]Gasterosteus aculeatus@ENSGACP00000006521[RRM1][KOG0548]
Danio rerio@ENSDARP00000075089[2][RRM1:100%][KOG0548:100%]Dictyostelium discoideum_AX4@XP_629218[RRM1][KOG0151]
Dictyostelium discoideum_AX4@XP_629218[RRM2][KOG0151]Volvox carteri@jgi_Volca1_88720[RRM3]
Chlamydomonas reinhardtii@jgi_Chlre3_148816[RRM2][KOG3598]Dictyostelium discoideum_AX4@XP_644288[RRM1][KOG3598]
Physcomitrella patens@jgi_Phypa1_1_176266[RRM1][KOG1924]Oryza sativa_japonica_cultivar-group@NP_001063671[RRM2][KOG0123]rosids@NP_001078046[5][RRM2:100%*][FCAFPA:80%*][KOG0117:80%*][.KOG0123:20%]
Physcomitrella patens@jgi_Phypa1_1_161310[RRM2][KOG3598]Physcomitrella patens@jgi_Phypa1_1_137240[2][RRM1:100%][KOG3598:50%]
Ricinus communis@30005_m001243[RRM1]Oryza sativa_japonica_cultivar-group@NP_001062811[RRM1][KOG1190]
Ricinus communis@29577_m000447[RRM1][KOG0123]Arabidopsis thaliana@NP_181869[4][RRM1:100%*][FCAFPA:100%*][KOG0117:100%*]
Encephalitozoon cuniculi_GB-M1@NP_586226[RRM1][put-sr][KOG0123]Dictyostelium discoideum_AX4@XP_645848[RRM2][put-sr]
Strongylocentrotus purpuratus@XP_798256[2][RRM1:100%][KOG2277:100%]Oryzias latipes@ENSORLP00000005442[2][RRM1:100%][KOG2277:100%]
Xenopus tropicalis@ENSXETP00000012439[RRM1][KOG2277]Oryctolagus cuniculus@ENSOCUP00000014792[RRM1][KOG2277]
Phytophthora@jgi_Physo1_1_138982[2][RRM1:100%][KOG0105:100%]Theileria parva_strain_Muguga@XP_766400[RRM2][put-sr][KOG4205]
Cyanidioschyzon merolae@gnl_CMER_CMT598C[RRM1][KOG0148]Theileria parva_strain_Muguga@XP_766728[RRM1][KOG0124]
Yarrowia lipolytica@XP_500797[RRM1][put-sr]Ustilago maydis_521@XP_758616[RRM1]
Schizosaccharomyces pombe_972h-@NP_596398[RRM1][put-sr][SR]Apis mellifera@XP_393878[RRM1][put-sr][KOG2193]
Ascomycota@YDL224C[8][RRM1:88%*][.RRM2:12%][KOG3598:12%][.KOG1457:12%]Ricinus communis@28452_m000049[RRM1][KOG1457]
Medicago truncatula@IMGA_CU012061_4_1[RRM1]Dictyostelium discoideum_AX4@XP_645848[RRM1][put-sr]
Caenorhabditis elegans@T11G6_8_1[2][RRM1:100%][KOG0153:100%]Coelomata@XP_975014[28][RRM1:100%***][RBM:86%***][KOG0153:100%***]
Ciona@ENSCSAVP00000015574[2][RRM1:100%][KOG0153:100%]Ostreococcus@jgi_Ost9901_3_41266[2][RRM1:100%][KOG0153:100%]
Embryophyta@jgi_Phypa1_1_185655[7][RRM1:100%*][KOG0153:100%*]Dictyostelium discoideum_AX4@XP_643642[RRM1][KOG0148]
Schizosaccharomyces pombe_972h-@NP_593427[RRM1][KOG0123]Kluyveromyces lactis@XP_454447[RRM3][KOG0128]
Apis mellifera@XP_394565[RRM1][KOG0147]Saccharomycetales@XP_454821[4][RRM1:100%*][KOG3598:50%][.KOG1984:25%]
Cryptosporidium parvum_Iowa_II@XP_626331[RRM1][KOG0146]Theileria parva_strain_Muguga@XP_766386[RRM1][put-sr][KOG0105]
Plasmodium falciparum_3D7@XP_001347876[RRM1][KOG0105]Neurospora crassa_OR74A@XP_958552[RRM1][KOG0128]
Saccharomyces cerevisiae@YMR268C[RRM1][KOG0128]Pichia stipitis_CBS_6054@XP_001384763[RRM1][KOG0123]
Cyanidioschyzon merolae@gnl_CMER_CMO009C[RRM2]Coelomata@ENSMMUP00000010529[37][RRM3:54%**][.RRM2:41%**][.RRM1:5%][put-sr:92%***][KOG0112:84%***][.KOG3598:8%*]
Strongylocentrotus purpuratus@XP_001184502[2][RRM2:100%][put-sr:100%][KOG1144:100%]Coelomata@XP_974651[54][RRM2:83%***][.RRM1:17%**][put-sr:87%***][RBM:37%**][KOG0112:100%***]
Nasonia vitripennis@XP_001604488[RRM1]Cryptosporidium parvum_Iowa_II@XP_627232[RRM1][put-sr][KOG0105]
Saccharomyces cerevisiae@YLL046C[RRM1]Plasmodium falciparum_3D7@XP_001347332[RRM1][put-sr][KOG0105]
Dictyostelium discoideum_AX4@XP_638672[RRM1][put-sr][KOG0147]Strongylocentrotus purpuratus@XP_001185906[2][RRM1:100%][KOG0107:100%]
Dictyostelium discoideum_AX4@XP_001134500[RRM1][put-sr][KOG0147]Eukaryota@ENSTBEP00000007356[92][RRM1:100%****][put-sr:82%****][SR:65%****][KOG0105:100%****]Embryophyta@NP_194280[13][RRM1:100%**][put-sr:77%**][SR:62%**][KOG0106:100%**]
Plasmodium falciparum_3D7@XP_001351730[RRM1][put-sr][KOG0105]Ostreococcus lucimarinus@jgi_Ost9901_3_8794[RRM1][KOG0105]
Caenorhabditis elegans@T28D9_2a[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*]Ciona intestinalis@ENSCINP00000016525[RRM1][put-sr][KOG0106]
Cavia porcellus@ENSCPOP00000010577[RRM1][put-sr][SR][KOG0106]Aedes aegypti@AAEL012621-PA[RRM1][put-sr][KOG0105]
Eukaryota@ENSOANP00000021053[127][RRM1:100%****][put-sr:91%****][SR:61%****][KOG0106:55%****][.KOG0105:37%***]Cryptococcus neoformans_var._neoformans_JEC21@XP_567562[RRM1][KOG0106]
Schizosaccharomyces pombe_972h-@NP_594570[RRM1][put-sr][KOG0106]Neurospora crassa_OR74A@XP_960334[RRM1][put-sr][KOG0105]
Chlamydomonas reinhardtii@jgi_Chlre3_152139[RRM1][KOG0117]Dictyostelium discoideum_AX4@XP_641568[RRM3][KOG3598]
Physcomitrella patens@jgi_Phypa1_1_161310[RRM3][KOG3598]Cryptosporidium parvum_Iowa_II@XP_626081[RRM1][KOG0122]
Embryophyta@jgi_Phypa1_1_161416[4][RRM1:100%*][put-sr:75%*][KOG0154:75%*][.KOG0147:25%]Phytophthora ramorum@jgi_Phyra1_1_77702[RRM1][KOG0154]
16 - dual-RRM
SR proteins
5553 - RBM
54
14 - RBM
34
85 - SRrp
76 - TIA TIAR
OligoU
86 - hnRNP
RALYL
Fungal SR (SpSrp1)
Fungal SR (SpSrp2)
Fig. S7
94
59
97
68
99
70
93
87
74
94
82
75
70 84
58
99
51
63
Ricinus communis@28976 m000161[RRM1][KOG4205]Ricinus communis@30170_m013671[RRM1][KOG4205]
Arabidopsis thaliana@NP_176143[RRM1][KOG4205]Chlamydomonadales@jgi_Volca1_107445[2][RRM1:100%][KOG4205:100%]
Cyanidioschyzon merolae@gnl_CMER_CMR392C[RRM1][KOG4205]Takifugu rubripes@SINFRUP00000163373[RRM1][KOG0149]
Takifugu rubripes@SINFRUP00000145256[RRM1][KOG0149]Thalassiosira pseudonana@jgi_Thaps3_25203[2][RRM1:100%][KOG4205:100%]
Phaeodactylum tricornutum@jgi_Phatr2_41450[RRM1][KOG4205]Ciona intestinalis@ENSCINP00000029053[RRM1][KOG4205]
Ciona intestinalis@ENSCINP00000006182[RRM1][KOG4205]Cryptosporidium parvum_Iowa_II@XP_626025[RRM1][KOG4205]
Chlamydomonadales@jgi_Chlre3_181880[2][RRM2:100%][KOG4205:100%]Drosophila melanogaster@CG9654-PA[RRM1][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_001388284[RRM1][KOG4205]Bacillariophyta@jgi_Phatr2_21039[2][RRM1:100%][KOG4205:100%]
Phytophthora ramorum@jgi_Phyra1_1_73884[RRM2][KOG4205]Aureococcus anophagefferens@jgi_Auran1_9576[RRM1][KOG0149]
Eukaryota@ENSMODP00000031317[289][RRM1:100%*****][hnRNP:28%****][.Musashi:13%***][.Dazap:9%***][KOG4205:99%*****]Bilateria@ENSRNOP00000022054[326][RRM1:100%*****][hnRNP:54%*****][KOG4205:100%*****]
Phytophthora ramorum@jgi_Phyra1_1_73884[RRM1][KOG4205]Aureococcus anophagefferens@jgi_Auran1_6078[RRM1][KOG4205]
Strongylocentrotus purpuratus@XP_001189292[2][RRM1:100%][KOG4205:100%]Strongylocentrotus purpuratus@XP_001176409[2][RRM1:100%][KOG4205:100%]
Viridiplantae@NP_851001[17][RRM2:100%**][put-sr:12%][KOG4205:94%**][.KOG1833:6%]Cryptococcus neoformans_var._neoformans_JEC21@XP_566745[2][RRM1:100%]
Endopterygota@AAEL008257-PA[8][RRM2:100%**][KOG4205:100%**]Ciona@ENSCSAVP00000001921[3][RRM2:100%*][Musashi:67%][KOG4205:100%*]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568675[RRM2][KOG4205]Caenorhabditis elegans@Y73B6BL_6b_3[10][RRM1:100%**][KOG4205:100%**]
Chlamydomonadales@jgi_Volca1_107445[2][RRM2:100%][KOG4205:100%]Ostreococcus lucimarinus@jgi_Ost9901_3_24530[RRM1][KOG4205]
Oryza sativa_japonica_cultivar-group@NP_001067093[RRM1][KOG4177]Ricinus communis@28976_m000161[RRM2][KOG4205]
Plasmodium falciparum_3D7@XP_001351452[RRM1][KOG4205]Saccharomycetales@XP_449511[7][RRM2:100%*][KOG4205:100%*]
Apis mellifera@XP_623573[RRM1][KOG0113]Ascomycota@XP_961230[5][RRM2:100%*][put-sr:20%][KOG4205:100%*]
Ustilago maydis_521@XP_758567[RRM2][KOG4205]Strongylocentrotus purpuratus@NP_999784[3][RRM1:100%*][KOG4205:100%*]
Dictyostelium discoideum_AX4@XP_629598[RRM2][KOG4205]Physcomitrella patens@jgi_Phypa1_1_19696[RRM1][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_001388284[RRM2][KOG4205]Cryptosporidium parvum_Iowa_II@XP_626579[RRM2][KOG4205]
Eukaryota@AGAP006656-PA[121][RRM2:88%****][.RRM1:12%**][Musashi:36%***][.Dazap:21%***][.hnRNP:10%**][KOG4205:100%****]Cryptosporidium parvum_Iowa_II@XP_626025[RRM2][KOG4205]
Strongylocentrotus purpuratus@NP_999784[3][RRM2:100%*][KOG4205:100%*]Strongylocentrotus purpuratus@XP_001183095[2][RRM2:100%][KOG4205:100%]
Strongylocentrotus purpuratus@XP_001176409[2][RRM2:100%][KOG4205:100%]Sorex araneus@ENSSARP00000008097[RRM2][hnRNP][KOG4205]
Ciona@ENSCINP00000008394[8][RRM2:100%**][KOG4205:100%**]Ciona intestinalis@ENSCINP00000012771[RRM2][put-sr][KOG4205]
Caenorhabditis elegans@F42A6_7a_1[8][RRM2:100%**][KOG4205:100%**]Coelomata@CG6354-PB[373][RRM2:95%*****][hnRNP:53%*****][KOG4205:100%*****]
Drosophila melanogaster@CG9654-PA[RRM2][KOG4205]Ciona@ENSCSAVP00000016637[3][RRM2:100%*][KOG4205:100%*]Ciona@ENSCINP00000028810[2][RRM2:100%][KOG4205:100%]Euteleostomi@ENSDARP00000005968[129][RRM2:95%****][.RRM1:5%*][hnRNP:57%****][KOG4205:100%****]
Endopterygota@XP_001121454[19][RRM2:100%**][KOG4205:100%**]Physcomitrella patens@jgi_Phypa1_1_120016[RRM2][KOG4205]
Caenorhabditis elegans@Y73B6BL_6a_3[10][RRM2:100%**][KOG4205:100%**]Plasmodium falciparum_3D7@XP_001347758[RRM1][KOG0149]
Plasmodium falciparum_3D7@XP_001347758[RRM2][KOG0149]Strongylocentrotus purpuratus@XP_789716[2][RRM2:100%][KOG4205:100%]
Strongylocentrotus purpuratus@XP_780859[2][RRM2:100%][KOG4205:100%]Chlamydomonadales@jgi_Volca1_43575[2][RRM3:100%][KOG4205:100%]
Encephalitozoon cuniculi_GB-M1@NP_597487[RRM1][KOG4205]Embryophyta@IMGA_AC144431_42_2[6][RRM3:100%*][put-sr:17%][KOG4205:100%*]
Embryophyta@jgi_Phypa1_1_112860[6][RRM2:100%*][put-sr:17%][KOG4205:100%*]Chlamydomonadales@jgi_Chlre3_105806[2][RRM2:100%][KOG4205:100%]
Theileria parva_strain_Muguga@XP_766722[RRM1][KOG0144]Ciona intestinalis@ENSCINP00000027768[RRM1][KOG0548]
Dictyostelium discoideum_AX4@XP_643007[RRM1]Dictyostelium discoideum_AX4@XP_641568[RRM2][KOG3598]
Aedes aegypti@AAEL010890-PA[RRM1][put-sr][KOG0132]Plasmodium falciparum_3D7@XP_001349292[RRM1][KOG0146]
Eutheria@ENSETEP00000000464[10][RRM1:100%**][put-sr:100%**][KOG0132:100%**]Endopterygota@CG4266-PA[5][RRM1:100%*][put-sr:100%*][KOG0132:100%*]
Thalassiosira pseudonana@jgi_Thaps3_2206[RRM1]Dictyostelium discoideum_AX4@XP_638966[RRM2][KOG0147]
Phaeodactylum tricornutum@jgi_Phatr2_38474[RRM1]Ustilago maydis_521@XP_760296[RRM1]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572996[RRM1]Ricinus communis@30169_m006629[RRM1][KOG0123]
Euteleostomi@ENSOANP00000013028[22][RRM1:100%***]Endopterygota@XP_967886[3][RRM1:100%*]
Drosophila melanogaster@CG14414-PB[RRM1]Zea mays@11279_m000026_AZM5_6772[RRM1][put-sr][KOG0117]
Oryza sativa_japonica_cultivar-group@NP_001067112[RRM2][put-sr][KOG0117]Chlamydomonadales@jgi_Volca1_107765[2][RRM1:100%][KOG0145:100%]
Embryophyta@jgi_Phypa1_1_217831[15][RRM3:93%**][.RRM1:7%][KOG0117:100%**]Ustilago maydis_521@XP_756401[RRM1]
Bilateria@ENSLAFP00000012959[197][RRM3:93%*****][.RRM2:5%**][hnRNP:36%****][KOG0117:100%*****]Strongylocentrotus purpuratus@XP_793277[2][RRM3:100%][KOG0117:100%]
Plasmodium falciparum_3D7@XP_966276[RRM2]Encephalitozoon cuniculi_GB-M1@NP_597181[RRM1][KOG0110]
Xenopus tropicalis@ENSXETP00000056096[RRM1][KOG0109]Mammalia@ENSTBEP00000003150[16][RRM1:100%**][RBM:94%**][KOG0109:100%**]
Clupeocephala@ENSGACP00000025151[11][RRM1:100%**][KOG0109:100%**]Endopterygota@CG7903-PA[5][RRM1:100%*][KOG0109:80%*]
Tribolium castaneum@XP_971700[RRM1]Clupeocephala@ENSORLP00000002364[10][RRM2:100%**][KOG0109:100%**]
Euteleostomi@ENSDNOP00000012760[63][RRM2:94%****][.RRM1:6%*][LARK:65%***][.RBM:21%**][KOG0109:97%****]Coelomata@ENSXETP00000008271[74][RRM1:100%****][LARK:61%***][KOG0109:97%****]
Strongylocentrotus purpuratus@XP_792521[4][RRM1:100%*][put-sr:100%*][KOG0109:100%*]Ciona intestinalis@ENSCINP00000023722[RRM1][KOG0109]
Ciona intestinalis@ENSCINP00000017840[RRM1][KOG0109]Ciona intestinalis@ENSCINP00000017840[RRM2][KOG0109]
Endopterygota@CG8597-PE[8][RRM2:100%**][LARK:62%*][KOG0109:100%**]Danio rerio@ENSDARP00000065401[RRM2][KOG0109]
Drosophila melanogaster@CG3312-PA[2][RRM1:100%][KOG0128:100%]Ustilago maydis_521@XP_758439[RRM3][KOG0123]
Ashbya gossypii_ATCC_10895@NP_984845[RRM2][KOG0123]Dictyostelium discoideum_AX4@XP_645138[RRM1]
Dictyostelium discoideum_AX4@XP_638767[RRM1][KOG0123]Aedes aegypti@AAEL012119-PA[RRM1]
Encephalitozoon cuniculi_GB-M1@NP_584552[RRM3][KOG0123]Dictyostelium discoideum_AX4@XP_641373[RRM1][put-sr]
Saccharomycetales@XP_455897[3][RRM1:100%*][KOG0123:67%]Strongylocentrotus purpuratus@XP_001185821[2][RRM1:100%][KOG0670:100%]
51 - LARK
50 - LARK
63 - hnRNP
52
35 - G3BP
RBM
30K RRM
hnRNP
Musashi
Dazap
TARDBP
OligoU
Fig. S7
95
64
79
95
51
64
68 64
96
59
77
77
71
Chlamydomonadales@jgi Volca1 107658[2][RRM1:100%][KOG4205:50%][ KOG0474:50%]Ciona intestinalis@ENSCINP00000024280[RRM1][KOG0113]
Aureococcus anophagefferens@jgi_Auran1_9018[RRM1]Strongylocentrotus purpuratus@XP_786044[2][RRM1:100%][KOG0117:100%]Aureococcus anophagefferens@jgi_Auran1_17889[RRM1][KOG4207]
Ustilago maydis_521@XP_761797[RRM2][put-sr][KOG3257]Euteleostomi@ENSGALP00000012472[36][RRM4:89%***][.RRM2:8%*][nucleolin:56%**][KOG0123:100%***]
Aspergillus fumigatus_Af293@XP_754840[RRM1][KOG0148]Neurospora crassa_OR74A@XP_963862[RRM1][KOG0127]
Basidiomycota@XP_566835[2][RRM1:100%][KOG0148:100%]Schizosaccharomyces pombe_972h-@NP_593531[RRM1][nucleolin][KOG0147]
Saccharomycetales@XP_456900[6][RRM1:100%*][nucleolin:17%][KOG0148:50%*][.KOG0131:33%][.KOG4210:17%]Yarrowia lipolytica@XP_505375[RRM1][KOG0148]
Ostreococcus tauri@jgi_Ostta4_31833[RRM2][KOG0148]Eukaryota@YHR086W[51][RRM3:76%***][.RRM2:20%**][oligoU:10%*][KOG0148:90%***]
Schizosaccharomyces pombe_972h-@NP_594243[RRM3][KOG0148]Phytophthora@jgi_Phyra1_1_50314[2][RRM3:100%][KOG0148:100%]
Aureococcus anophagefferens@jgi_Auran1_28594[RRM3][KOG0148]Aspergillus fumigatus_Af293@XP_754657[RRM1]
Cryptococcus neoformans_var._neoformans_JEC21@XP_566835[RRM2][KOG0148]Ustilago maydis_521@XP_762340[RRM2][KOG0148]Pezizomycotina@XP_754840[2][RRM2:100%][KOG0127:50%][.KOG0148:50%]Saccharomycetales@XP_456900[7][RRM2:100%*][nucleolin:14%][KOG0148:57%*][.KOG0131:29%][.KOG4210:14%]
Schizosaccharomyces pombe_972h-@NP_593531[RRM2][nucleolin][KOG0147]rosids@NP_568388[3][RRM1:100%*][KOG0125:33%][.KOG0148:33%]
Physcomitrella patens@jgi_Phypa1_1_151460[4][RRM1:100%*][KOG0108:75%*][.KOG0149:25%]Strongylocentrotus purpuratus@XP_793862[2][RRM2:100%][KOG0144:100%]
Aureococcus anophagefferens@jgi_Auran1_8994[RRM1][KOG0149]Phytophthora@jgi_Physo1_1_134615[2][RRM1:100%]
Aureococcus anophagefferens@jgi_Auran1_66158[RRM2][put-sr][KOG0149]Oryza sativa_japonica_cultivar-group@NP_001045556[RRM1][KOG0108]
Magnoliophyta@NP_566958[6][RRM2:67%*][.RRM1:33%][KOG0123:33%][.KOG0124:33%][.KOG0131:33%]Yarrowia lipolytica@XP_505724[RRM1][KOG4198]
Volvox carteri@jgi_Volca1_103054[RRM2][KOG0055]Tribolium castaneum@XP_970765[RRM1][KOG0127]
Ostreococcus@jgi_Ost9901_3_710[2][RRM4:100%][KOG0110:100%]Magnoliophyta@NP_193696[2][RRM3:100%][KOG0110:100%]
Apocrita@XP_001605134[2][RRM5:100%][KOG0110:100%]Phytophthora sojae@jgi_Physo1_1_129427[RRM4][KOG0110]
Euteleostomi@ENSGALP00000013474[20][RRM5:85%**][.RRM4:5%][.RRM3:5%][.RRM2:5%][put-sr:10%][KOG0110:100%**]Thalassiosira pseudonana@jgi_Thaps3_268689[RRM4][KOG0110]
Phaeodactylum tricornutum@jgi_Phatr2_20740[RRM4][KOG0110]Cryptosporidium parvum_Iowa_II@XP_627799[RRM4][KOG0110]
Ascomycota@XP_001386803[10][RRM4:90%**][.RRM2:10%][KOG0110:100%**]Cryptococcus neoformans_var._neoformans_JEC21@XP_569873[RRM4][KOG0110]
Aureococcus anophagefferens@jgi_Auran1_9354[RRM1]Aureococcus anophagefferens@jgi_Auran1_60739[RRM1][put-sr][KOG1860]
Ostreococcus tauri@jgi_Ostta4_19569[RRM1][KOG0127]Ostreococcus lucimarinus@jgi_Ost9901_3_26255[RRM1][KOG0127]
Arabidopsis thaliana@NP_179762[RRM1][oligoU]Thalassiosira pseudonana@jgi_Thaps3_20887[RRM1]
Phaeodactylum tricornutum@jgi_Phatr2_44468[RRM1]Magnoliophyta@NP_001059075[6][RRM1:100%*][put-sr:17%][GRSRBP:50%*][KOG0108:50%*][.KOG0148:33%][.KOG0111:17%]
Eukaryota@jgi_Phypa1_1_37849[169][RRM1:100%*****][put-sr:5%**][GRSRBP:33%****][.hnRNP:18%***][.RBMY:15%***][KOG0108:23%***][.KOG0111:23%***][.KOG0149:18%***][.KOG0117:11%**][.KOG0116:9%**]Phaeodactylum tricornutum@jgi_Phatr2_49481[RRM1][KOG1337]
Dictyostelium discoideum_AX4@XP_629578[RRM1][KOG0122]Ciona@ENSCINP00000012771[9][RRM1:100%**][put-sr:11%][KOG4205:100%**]
Neurospora crassa_OR74A@XP_965346[RRM1][KOG0110]Eukaryota@XP_391240[27][RRM2:67%**][.RRM1:33%**][cpRNP:19%*][KOG0127:48%**][.KOG0108:22%*][.KOG0131:15%*][.KOG0149:7%][.KOG0145:7%]
Phaeodactylum tricornutum@jgi_Phatr2_8270[RRM1][KOG4207]Bacillariophyta@jgi_Thaps3_20223[2][RRM1:100%][KOG0108:100%]Thalassiosira pseudonana@jgi_Thaps3_20266[RRM1][KOG4207]
Chlamydomonadales@jgi_Chlre3_184151[2][RRM1:100%][KOG0921:50%][.KOG0116:50%]Ostreococcus@jgi_Ost9901_3_12693[2][RRM2:100%][KOG0127:100%]
Aureococcus anophagefferens@jgi_Auran1_9375[2][RRM1:100%][KOG0122:100%]Aureococcus anophagefferens@jgi_Auran1_17018[RRM1][KOG0111]
Phaeodactylum tricornutum@jgi_Phatr2_33658[RRM1]Aureococcus anophagefferens@jgi_Auran1_31715[RRM1][KOG0149]
Phytophthora@jgi_Phyra1_1_84416[2][RRM1:100%][KOG0148:100%]Embryophyta@jgi_Phypa1_1_156290[6][RRM1:100%*][put-sr:17%][KOG4205:100%*]
Phaeodactylum tricornutum@jgi_Phatr2_21039[RRM2][KOG4205]Dictyostelium discoideum_AX4@XP_643856[3][RRM1:100%*][KOG0149:100%*]
Caenorhabditis elegans@C50B8_1[RRM1]Diptera@AAEL008317-PA[3][RRM1:100%*][KOG0149:100%*]Diptera@AAEL006645-PA[2][RRM1:100%][KOG0149:100%]
Euteleostomi@ENSSTOP00000002923[18][RRM1:100%**][KOG4205:11%]Strongylocentrotus purpuratus@XP_001188704[2][RRM1:100%][KOG0149:100%]
Plasmodium falciparum_3D7@XP_001352039[RRM1][KOG0144]Cryptosporidium parvum_Iowa_II@XP_628599[RRM1][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_626158[RRM2][KOG0144]Plasmodium falciparum_3D7@XP_001352039[RRM2][KOG0144]
Cryptosporidium parvum_Iowa_II@XP_628599[RRM2][KOG4205]Dictyostelium discoideum_AX4@XP_641688[RRM1][KOG0117]Volvox carteri@jgi_Volca1_116517[RRM2][KOG1984]
Coelomata@ENSTBEP00000005385[105][RRM2:86%****][.RRM1:14%**][P54nrb:30%***][.PSP1:24%***][.PSF:21%***][KOG0115:100%****]Dictyostelium discoideum_AX4@XP_646802[RRM2][KOG0145]
Arabidopsis thaliana@NP_187353[RRM1][30kRRM][KOG0149]Eukaryota@NP_001058102[93][RRM1:100%****][RBM:52%***][.30kRRM:13%**][KOG0149:96%****]
Arabidopsis thaliana@NP_200183[2][RRM1:100%][oligoU:100%][KOG0149:100%]Phytophthora sojae@jgi_Physo1_1_139371[RRM1][KOG4205]
Physcomitrella patens@jgi_Phypa1_1_96043[RRM1]Oryza sativa_japonica_cultivar-group@NP_001054022[RRM1][KOG4205]
Magnoliophyta@NP_001042672[10][RRM1:100%**][oligoU:50%*][KOG4205:80%**][.KOG0149:20%]Arabidopsis thaliana@NP_850021[4][RRM1:100%*][oligoU:100%*][KOG0149:75%*][.KOG2186:25%]
Cyanidioschyzon merolae@gnl_CMER_CMR392C[RRM2][KOG4205]Ostreococcus tauri@jgi_Ostta4_33731[RRM2]
Ostreococcus tauri@jgi_Ostta4_33731[RRM1]Dictyostelium discoideum_AX4@XP_643377[RRM1][KOG3598]
Caenorhabditis elegans@F56D1_7[RRM1]Coelomata@AAEL001684-PA[39][RRM1:100%***][KOG0125:21%**]
Euteleostomi@ENSEEUP00000005436[64][RRM1:95%****]Takifugu rubripes@SINFRUP00000155469[RRM1]
Tupaia belangeri@ENSTBEP00000015084[RRM1]Spermophilus tridecemlineatus@ENSSTOP00000003171[RRM1]
Oryza sativa_japonica_cultivar-group@NP_001058805[RRM1][KOG4205]Zea mays@14684_m000016_AZM5_14964[RRM1][KOG4205]
Oryza sativa_japonica_cultivar-group@NP_001051402[RRM1][KOG0149]Ciona@ENSCINP00000009845[4][RRM1:100%*][KOG0116:100%*]
Deuterostomia@ENSMODP00000011218[78][RRM1:100%****][G3BP:82%****][KOG0116:100%****]Tribolium castaneum@XP_975463[RRM1][KOG0116]
Apis mellifera@XP_623996[RRM1][KOG0116]Chlamydomonadales@jgi_Chlre3_105806[2][RRM1:100%][KOG4205:100%]
Coelomata@SINFRUP00000146060[58][RRM1:100%****][TARDBP:72%***][KOG4205:98%****]Strongylocentrotus purpuratus@XP_789716[2][RRM1:100%][KOG4205:100%]
Endopterygota@CG16901-PC[19][RRM1:100%**][KOG4205:100%**]Oryctolagus cuniculus@ENSOCUP00000001170[RRM1][hnRNP][KOG4205]
Myotis lucifugus@ENSMLUP00000003070[RRM1][hnRNP][KOG4205]Theileria parva_strain_Muguga@XP_766400[RRM1][put-sr][KOG4205]
Plasmodium falciparum_3D7@XP_001351452[RRM2][KOG4205]Ricinus communis@28976_m000161[RRM1][KOG4205]
58 - GRSRBP
hnRNP
RBMY
59
78 - OligoU
associated to node 4 in RaxML and merge-RaxML
Fig. S7
96
51
71
54
53
85
57 57
78 67
57
52
87 50
91
93
65 51
73
73
75
Aspergillus fumigatus Af293@XP 750045[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_569809[RRM1][KOG0130]
Plasmodium falciparum_3D7@XP_001348230[RRM1][KOG0130]Yarrowia lipolytica@XP_503462[RRM1][put-sr][KOG0130]
Ustilago maydis_521@XP_760711[RRM1][put-sr][KOG0687]Eukaryota@jgi_Thaps3_18841[52][RRM1:100%***][put-sr:56%***][RBM:42%***][KOG0130:100%***]
Phaeodactylum tricornutum@jgi_Phatr2_20716[RRM1][KOG0130]Murinae@ENSMUSP00000078984[3][RRM1:100%*][KOG4207:100%*]
Dictyostelium discoideum_AX4@XP_628876[RRM1]Plasmodium falciparum_3D7@XP_001352080[RRM2]
Caenorhabditis elegans@Y55F3AM_3c_1[3][RRM2:100%*][put-sr:33%][UMH:100%*][KOG0147:100%*]Thalassiosira pseudonana@jgi_Thaps3_33709[RRM1][KOG0111]
Schizosaccharomyces pombe_972h-@NP_595090[RRM1]Bacillariophyta@jgi_Thaps3_19374[2][RRM1:100%][KOG0121:100%]
Theileria parva_strain_Muguga@XP_766484[RRM1][KOG0121]Plasmodium falciparum_3D7@XP_001351463[RRM1][KOG0121]
Eukaryota@ENSMODP00000034858[66][RRM1:100%****][KOG0121:100%****]Trypanosomatidae@XP_001466901[2][RRM1:100%][KOG0121:100%]
Encephalitozoon cuniculi_GB-M1@NP_597585[RRM1][KOG0121]Cryptosporidium parvum_Iowa_II@XP_627536[RRM1][KOG0121]
Yarrowia lipolytica@XP_500351[RRM1][KOG0123]Endopterygota@CG5655-PA[5][RRM1:100%*][put-sr:100%*][KOG0107:80%*][.KOG0921:20%]
Strongylocentrotus purpuratus@XP_001178467[2][RRM1:100%][put-sr:100%]Eukaryota@ENSGALP00000022397[157][RRM1:100%*****][put-sr:75%****][SR:59%****][KOG0107:66%****]
Strongylocentrotus purpuratus@XP_001180596[2][RRM1:100%][put-sr:100%]Pezizomycotina@XP_961985[2][RRM1:100%][KOG0116:50%]
Aureococcus anophagefferens@jgi_Auran1_69134[RRM1][put-sr]Tetraodontidae@GSTENP00014994001[2][RRM1:50%][.RRM3:50%][KOG0123:50%]
Euteleostomi@GSTENP00022906001[41][RRM3:83%***][.RRM2:10%*][.RRM1:7%*][nucleolin:54%***][KOG0123:93%***]Neurospora crassa_OR74A@XP_964541[RRM1]
Aspergillus fumigatus_Af293@XP_748929[RRM1]Phytophthora@jgi_Physo1_1_136528[2][RRM1:100%][put-sr:50%][KOG3208:50%]
Aureococcus anophagefferens@jgi_Auran1_17068[RRM1][KOG4207]Cryptosporidium parvum_Iowa_II@XP_628282[2][RRM1:100%][put-sr:100%][KOG0111:50%][.KOG4207:50%]
Plasmodium falciparum_3D7@XP_001351591[RRM1]Plasmodium falciparum_3D7@XP_001347950[RRM1][KOG4207]
Chordata@ENSETEP00000001114[45][RRM1:100%***][put-sr:96%***][SRrp:82%***][KOG0111:29%**][.KOG0415:13%*]Viridiplantae@NP_001046448[23][RRM1:100%***][put-sr:91%***][SR:35%**][KOG4207:13%*][.KOG0127:13%*][.KOG0110:9%]Chlamydomonadales@jgi_Volca1_121229[2][RRM1:100%][put-sr:100%][KOG0415:50%]
Bacillariophyta@jgi_Thaps3_23196[2][RRM1:100%][KOG4207:50%]Phytophthora sojae@jgi_Physo1_1_138511[RRM1][put-sr]
Eukaryota@8925_m000027_AZM5_1178[67][RRM1:100%****][put-sr:84%****][SR:61%***][KOG4207:61%***][.KOG4368:24%**]Cyanidioschyzon merolae@gnl_CMER_CML202C[RRM1][put-sr]
Gammaproteobacteria@YP_113294[2][RRM1:100%][PROK:100%]Magnoliophyta@NP_001060859[5][RRM1:100%*][cpRNP:40%][KOG0110:40%][.KOG0148:40%]
Phaeodactylum tricornutum@jgi_Phatr2_16633[RRM1][KOG0125]Tribolium castaneum@XP_970765[RRM2][KOG0127]
Ostreococcus lucimarinus@jgi_Ost9901_3_8174[RRM1][KOG4207]Dictyostelium discoideum_AX4@XP_647083[RRM1]
Cryptococcus neoformans_var._neoformans_JEC21@XP_567374[RRM1][KOG0307]Embryophyta@30128_m008555[15][RRM1:100%**][KOG4660:100%**]
Chlamydomonas reinhardtii@jgi_Chlre3_152680[RRM1][KOG4660]Drosophila melanogaster@CG5213-PA[RRM2][KOG0145]
Deuterostomia@ENSDNOP00000008593[94][RRM1:100%****][P54nrb:28%***][.PSP1:21%**][.PSF:18%**][KOG0115:99%****]Endopterygota@CG10328-PA[9][RRM1:100%**][P54nrb:33%*][KOG0115:100%**]
Caenorhabditis elegans@F25B5_7d[2][RRM1:100%][KOG0115:100%]Legionella_pneumophila@YP_001249669[3][RRM1:100%*][PROK:100%*][put-sr:100%*][KOG0149:100%*]
Ostreococcus lucimarinus@jgi_Ost9901_3_7602[RRM1][KOG0145]Coxiella_burnetii@YP_001424629[2][RRM1:100%][PROK:100%][KOG0108:100%]
Embryophyta@jgi_Phypa1_1_44443[2][RRM2:100%][KOG0149:100%]Embryophyta@29900_m001607[13][RRM2:100%**][oligoU:38%*][KOG4205:77%**][.KOG0149:23%*]
Aspergillus fumigatus_Af293@XP_747328[RRM1][KOG0110]Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM2][KOG0123]
Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM1][KOG4212]Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM1][put-sr][KOG0147]
Phytophthora@jgi_Physo1_1_140403[2][RRM1:100%][put-sr:100%][KOG0127:100%]Volvox carteri@jgi_Volca1_72841[RRM1][KOG0144]
Eukaryota@NP_001063859[35][RRM1:100%***][ZCRB1:69%***][KOG0108:40%**][.KOG0122:9%*][.KOG0117:6%][.KOG0107:6%]Phytophthora ramorum@jgi_Phyra1_1_94226[RRM1][put-sr][KOG0941]
Aedes aegypti@AAEL006197-PA[RRM1][KOG0108]Yarrowia lipolytica@XP_500351[RRM2][KOG0123]
Cryptococcus neoformans_var._neoformans_JEC21@XP_571608[RRM1][put-sr][KOG0151]Eukaryota@jgi_Volca1_104604[49][RRM1:100%***][put-sr:78%***][KOG0151:100%***]
Plasmodium falciparum_3D7@XP_001348201[RRM1][KOG0151]Cyanidioschyzon merolae@gnl_CMER_CMS187C[RRM1][KOG0123]
Chlamydomonas reinhardtii@jgi_Chlre3_194261[RRM1][KOG0123]Embryophyta@NP_001063403[14][RRM1:100%**][KOG0148:100%**]Endopterygota@XP_974444[2][RRM1:100%][KOG0144:100%]
Clupeocephala@ENSORLP00000016619[5][RRM1:100%*][KOG0131:60%*][.KOG0123:40%]Trypanosomatidae@XP_001469326[2][RRM1:100%][KOG0123:100%]
Eukaryota@ENSXETP00000023927[236][RRM1:100%*****][PABP:55%****][KOG0123:100%*****]Tetraodon nigroviridis@GSTENP00024897001[RRM1][PABP][KOG0123]Trypanosomatidae@XP_001469222[2][RRM1:100%][KOG0123:100%]
Leishmania infantum_JPCM5@XP_001466041[RRM1][KOG0123]Saccharomycetaceae@YFR023W[4][RRM1:100%*][KOG0123:100%*]
Candida glabrata_CBS138@XP_447635[RRM1][KOG0123]Danio rerio@ENSDARP00000091192[14][RRM1:100%**][put-sr:100%**][KOG0123:100%**]
rosids@30078_m002213[3][RRM1:100%*][PABP:33%][KOG0123:100%*]Oryza sativa_japonica_cultivar-group@NP_001049727[RRM1][KOG0123]Ricinus communis@30146_m003481[RRM1][KOG0123]
Arabidopsis thaliana@NP_188259[RRM1][PABP][KOG0123]Ciona intestinalis@ENSCINP00000004384[RRM2][KOG0148]
Strongylocentrotus purpuratus@XP_001183631[2][RRM2:100%][KOG0148:100%]Physcomitrella patens@jgi_Phypa1_1_170658[RRM1]
Thalassiosira pseudonana@jgi_Thaps3_18991[RRM1][KOG0226]Phaeodactylum tricornutum@jgi_Phatr2_13402[RRM1][KOG0226]
Cryptococcus neoformans_var._neoformans_JEC21@XP_571861[RRM1][KOG0226]Eukaryota@XP_964958[72][RRM1:100%****][KOG0226:100%****]Nasonia vitripennis@XP_001603091[RRM1][KOG0226]
Yarrowia lipolytica@XP_501542[RRM2][KOG0131]Eukaryota@IMGA_AC144483_30_2[123][RRM2:83%****][.RRM1:17%***][TIATIAR:58%****][.oligoU:6%*][KOG0148:99%****]
Ustilago maydis_521@XP_757329[RRM2][KOG0145]Endopterygota@AAEL011988-PA[5][RRM2:100%*][KOG0144:80%*][.KOG0145:20%]
Dictyostelium discoideum_AX4@XP_635179[RRM1][KOG0148]Aureococcus anophagefferens@jgi_Auran1_28594[RRM2][KOG0148]
Pichia stipitis_CBS_6054@XP_001386002[RRM2][KOG0148]Debaryomyces hansenii_CBS767@XP_461354[RRM2][KOG0148]Ciona@ENSCSAVP00000020066[4][RRM1:50%][.RRM2:50%][KOG0131:50%]
Saccharomycetales@XP_460477[6][RRM1:67%*][.RRM2:33%][KOG0148:67%*][.KOG3598:17%][.KOG0145:17%]Saccharomycetales@XP_455748[4][RRM2:100%*][KOG0148:75%*][.KOG0145:25%]
Eukaryota@ENSMUSP00000030730[72][RRM2:85%****][.RRM1:15%**][oligoU:10%*][KOG0148:58%***][.KOG0123:25%**][.KOG0131:14%**]Pezizomycotina@XP_961985[2][RRM2:100%][KOG0116:50%]
Schizosaccharomyces pombe_972h-@NP_595090[RRM2]Phytophthora@jgi_Phyra1_1_75647[2][RRM1:100%]
Ciona intestinalis@ENSCINP00000008726[RRM1][put-sr][KOG2193]Candida glabrata_CBS138@XP_445637[RRM1]
Ashbya gossypii_ATCC_10895@NP_983970[RRM1]Eukaryota@ENSETEP00000015606[204][RRM3:85%*****][.RRM2:11%***][PABP:66%****][KOG0123:100%*****]
Oryza sativa_japonica_cultivar-group@NP_001054954[2][RRM1:100%][KOG0108:100%]Chlamydomonadales@jgi_Volca1_107658[2][RRM1:100%][KOG4205:50%][.KOG0474:50%]
77 - TIA TIAR
OligoU
66 - PABP
3 - PABP
13
57 - ZCRB1
33 - p54nrb
PSP1
PSF42
22 - single-RRM
SR proteins
23 - SRrp
15
17 - single-RRM
Zn-K SR proteins
24
20 - RBM
Fig. S7
97
58
98 82
95
77
77 89
93
57
65
98
66
66
84 59
59
61
96
88
50
Neurospora crassa OR74A@XP 965014[RRM2][KOG0110]Phaeodactylum tricornutum@jgi_Phatr2_20740[RRM2][KOG0110]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569873[RRM2][KOG0110]Caenorhabditis elegans@T23F6_4_1[2][RRM3:100%][KOG0110:100%]
Eukaryota@IMGA_AC183923_6_1[34][RRM3:74%***][.RRM1:15%*][.RRM2:12%*][put-sr:6%][KOG0110:100%***]Oryza sativa_japonica_cultivar-group@NP_001053839[RRM1][KOG0110]
Aspergillus fumigatus_Af293@XP_750233[RRM2][KOG0110]Saccharomycetales@NP_984131[7][RRM2:100%*][KOG0110:100%*]
Schizosaccharomyces pombe_972h-@NP_595599[RRM2][KOG0110]Euteleostomi@GSTENP00013801001[29][RRM1:100%***][LA:59%**][KOG1855:100%***]
Euteleostomi@ENSORLP00000006283[2][RRM1:100%][LA:50%][KOG1855:100%]Apocrita@XP_001600355[2][RRM1:100%][KOG1855:100%]
Tribolium castaneum@XP_974730[RRM1][KOG1855]Ciona@ENSCSAVP00000005375[4][RRM2:75%*][.RRM1:25%][KOG0116:75%*][.KOG2141:25%]
Physcomitrella patens@jgi_Phypa1_1_167900[3][RRM1:100%*][KOG0123:33%][.KOG4210:33%][.KOG1015:33%]Deuterostomia@ENSXETP00000012868[47][RRM1:100%***][KOG4454:60%***][.KOG0131:40%**]
Endopterygota@AGAP002256-PA[4][RRM1:100%*][KOG4454:75%*][.KOG0131:25%]Drosophila melanogaster@CG11454-PA[RRM1][KOG4454]
Magnoliophyta@NP_001055607[4][RRM1:100%*][put-sr:25%][KOG0131:100%*]Caenorhabditis elegans@Y37D8A_21_1[2][RRM1:100%][KOG4454:100%]
Plasmodium falciparum_3D7@XP_001348367[RRM1][KOG0131]Cryptosporidium parvum_Iowa_II@XP_627780[RRM1][KOG0131]
Eukaryota@NP_001064759[59][RRM1:100%****][snRNP:8%*][KOG0131:100%****]Saccharomycetaceae@XP_001385635[2][RRM1:100%][KOG0131:100%]
Dictyostelium discoideum_AX4@XP_647248[RRM1][KOG0131]Ashbya gossypii_ATCC_10895@NP_982888[RRM1][KOG0131]
Saccharomyces cerevisiae@YOR319W[RRM1][KOG0131]Candida glabrata_CBS138@XP_447678[RRM1][KOG0131]
Leishmania infantum_JPCM5@XP_001468615[RRM1]Dictyostelium discoideum_AX4@XP_641693[RRM1][KOG0122]
Yarrowia lipolytica@XP_503515[RRM1][KOG0122]Saccharomycetales@XP_446998[3][RRM1:100%*][KOG0122:100%*]
Saccharomycetaceae@XP_001388004[2][RRM1:100%][KOG0122:100%]Caenorhabditis elegans@F22B5_2[RRM1][KOG0122]
Cryptococcus neoformans_var._neoformans_JEC21@XP_567824[RRM1][KOG0122]Eukaryota@NP_187747[49][RRM1:100%***][KOG0122:98%***]
Medicago truncatula@IMGA_AC144431_18_2[RRM1][KOG0122]Apicomplexa@XP_001388056[3][RRM1:100%*][KOG0122:100%*]
Cyanidioschyzon merolae@gnl_CMER_CMH159C[RRM1][KOG0122]Encephalitozoon cuniculi_GB-M1@NP_584580[RRM1][KOG0114]
Eukaryota@jgi_Phatr2_8132[54][RRM1:100%***][KOG0114:100%***]Schizosaccharomyces pombe_972h-@NP_594609[RRM1][KOG4660]
Debaryomyces hansenii_CBS767@XP_458197[RRM1][KOG0114]Theria@ENSMODP00000002817[2][RRM1:100%]
Amniota@ENSMODP00000004174[11][RRM4:55%*][.RRM3:36%*][.RRM2:9%][put-sr:100%**][KOG0112:100%**]Tribolium castaneum@XP_969008[RRM2][KOG0331]
Theileria parva_strain_Muguga@XP_764943[RRM1][KOG4206]Coelomata@ENSORLP00000008206[18][RRM1:100%**][snRNP:83%**][KOG4206:100%**]
Sordariomycetes@XP_962704[2][RRM1:100%][put-sr:50%][KOG4206:100%]Pichia stipitis_CBS_6054@XP_001382592[RRM1][KOG4206]Saccharomyces cerevisiae@YBR119W[RRM1]
Plasmodium falciparum_3D7@XP_001349796[RRM2][KOG4206]Pezizomycotina@XP_753458[2][RRM2:100%][put-sr:50%][KOG4206:100%]
Schizosaccharomyces pombe_972h-@NP_596424[RRM2][KOG4206]Cryptococcus neoformans_var._neoformans_JEC21@XP_568533[RRM2][KOG4206]
Eukaryota@ENSGACP00000013006[79][RRM2:96%****][snRNP:30%***][KOG4206:100%****]Theileria parva_strain_Muguga@XP_764943[RRM2][KOG4206]
Embryophyta@IMGA_AC141435_12_2[17][RRM2:76%**][.RRM1:24%*][KOG4660:100%**]Drosophila melanogaster@CG2050-PA[RRM3]
Ciona@ENSCSAVP00000017501[2][RRM1:50%][.RRM2:50%][KOG0109:50%]Myotis lucifugus@ENSMLUP00000003020[RRM3][PTBP][KOG1190]
Phytophthora@jgi_Phyra1_1_74707[2][RRM3:100%][KOG0110:100%]Volvox carteri@jgi_Volca1_63158[RRM2][KOG0110]
Tetrapoda@ENSXETP00000004736[17][RRM2:59%**][.RRM1:41%*][PTBP:94%**][KOG1190:100%**]Saccharomyces cerevisiae@YMR302C[RRM1]
Leishmania infantum_JPCM5@XP_001466413[RRM3][put-sr][KOG0147]Trypanosoma brucei_TREU927@XP_951655[RRM3][put-sr][KOG0109]
Trypanosoma brucei_TREU927@XP_951655[RRM2][put-sr][KOG0109]Embryophyta@jgi_Phypa1_1_201182[6][RRM2:100%*][KOG0127:100%*]
Ostreococcus@jgi_Ost9901_3_26255[2][RRM2:100%][KOG0127:100%]Chlamydomonas reinhardtii@jgi_Chlre3_186870[RRM2][KOG0127]
Schizosaccharomyces pombe_972h-@NP_596114[RRM2][KOG0127]Pezizomycotina@XP_962933[3][RRM2:100%*][KOG0127:100%*]
Saccharomycetales@XP_459044[4][RRM2:100%*][KOG0127:100%*]Yarrowia lipolytica@XP_499726[RRM2][KOG0127]
Chordata@ENSOGAP00000005376[31][RRM2:90%***][.RRM3:6%][RBM:39%**][KOG0127:100%***]Tribolium castaneum@XP_974350[RRM1][KOG0127]
Nasonia vitripennis@XP_001605703[RRM2][KOG0127]Apis mellifera@XP_624495[RRM1][KOG0127]
Nasonia vitripennis@XP_001605703[RRM1][KOG0127]Drosophila melanogaster@CG4806-PA[RRM1][KOG0127]
Aedes aegypti@AAEL008572-PA[RRM1][KOG0127]Magnoliophyta@NP_001062073[4][RRM1:100%*][KOG0110:75%*][.KOG0127:25%]
Trypanosoma brucei_TREU927@XP_829716[RRM1]Aedes aegypti@AAEL010888-PA[RRM2]
Encephalitozoon cuniculi_GB-M1@NP_586099[RRM2][KOG0131]Cyanidioschyzon merolae@gnl_CMER_CMG025C[RRM1][KOG1080]
Saccharomyces cerevisiae@YOR319W[RRM2][KOG0131]Euteleostomi@ENSORLP00000016244[7][RRM1:100%*][KOG1080:57%*]
Aedes aegypti@AAEL010807-PA[RRM1][put-sr][KOG1080]Sordariomycetes@XP_001522188[3][RRM1:100%*][put-sr:67%]
Schizosaccharomyces pombe_972h-@NP_596549[RRM1][put-sr]Cryptococcus neoformans_var._neoformans_JEC21@XP_569824[RRM1][put-sr]
Coelomata@ENSMUSP00000057332[45][RRM1:100%***][put-sr:100%***][RNPS1:64%***][KOG4209:87%***]Caenorhabditis elegans@K02F3_11_2[2][RRM1:100%][put-sr:100%][KOG4209:100%]
Dictyostelium discoideum_AX4@XP_636445[RRM1][put-sr]Viridiplantae@jgi_Phypa1_1_105411[8][RRM1:100%**][put-sr:100%**][SR:25%][KOG0117:12%][.KOG0462:12%]
Phytophthora@jgi_Physo1_1_138873[2][RRM1:100%][put-sr:100%][KOG1611:50%]Plasmodium falciparum_3D7@XP_001348607[RRM1]
Trypanosomatidae@XP_843959[2][RRM3:100%]Aedes aegypti@AAEL010887-PA[RRM6][put-sr][KOG1984]
Plasmodium falciparum_3D7@XP_001347479[RRM1]Debaryomyces hansenii_CBS767@XP_460681[RRM3][KOG0128]
Saccharomyces cerevisiae@YMR268C[RRM3][KOG0128]Candida glabrata_CBS138@XP_446891[RRM3][KOG0128]
Encephalitozoon cuniculi_GB-M1@NP_585779[RRM1]Mammalia@ENSETEP00000003776[19][RRM1:100%**][LA:95%**][KOG4213:100%**]
Aedes aegypti@AAEL006876-PA[RRM1][KOG2193]Plasmodium falciparum_3D7@XP_001352162[RRM1]Plasmodium falciparum_3D7@XP_001351468[RRM1]
Saccharomycetales@XP_462132[6][RRM1:100%*][KOG0533:100%*]Sordariomycetes@XP_956471[2][RRM1:100%][KOG0533:100%]
Schizosaccharomyces pombe_972h-@NP_595715[RRM1][KOG0533]Ustilago maydis_521@XP_760032[RRM1][KOG0533]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572037[RRM1][KOG0533]Dictyostelium discoideum_AX4@XP_642758[RRM1]Ostreococcus@jgi_Ostta4_7793[2][RRM1:100%][KOG0108:100%]
Aureococcus anophagefferens@jgi_Auran1_71372[2][RRM3:50%][.RRM2:50%][put-sr:100%][KOG1178:100%]Ostreococcus lucimarinus@jgi_Ost9901_3_32831[RRM1]
Aspergillus fumigatus_Af293@XP_750045[RRM1]
84 - La
26 - SR45
27 - RNPS1 28
71 - RBM
41 - snRNP
40 - snRNP
45
43
44
65
46
47
49
81 - La
3233 - p54nrb
PSP1
PSf
Fungal SpRnps1
Fig. S7
98
60
51
97
69
91
95
81
71 53
92 93
99
92
69
63
96
Ustilago maydis 521@XP 756311[RRM2][put sr][KOG0147]Bilateria@Y47G6A_20a[64][RRM1:100%****][UMH:73%***][KOG0124:100%****]
Dictyostelium discoideum_AX4@XP_638262[RRM1][put-sr][KOG0670]Phytophthora ramorum@jgi_Phyra1_1_81440[2][RRM1:100%][KOG0124:100%]
Cryptosporidium parvum_Iowa_II@XP_628096[RRM1][put-sr][KOG0124]Eukaryota@ENSFCAP00000006163[84][RRM2:88%****][.RRM1:12%**][put-sr:86%****][UMH:39%***][.CAPER:8%*][KOG0147:100%****]
Bacillariophyta@jgi_Phatr2_20857[2][RRM2:100%][put-sr:100%][KOG0147:100%]Dictyostelium discoideum_AX4@XP_638262[RRM2][put-sr][KOG0670]
Cryptosporidium parvum_Iowa_II@XP_628096[RRM2][put-sr][KOG0124]Phytophthora@jgi_Phyra1_1_84640[3][RRM2:67%][.RRM1:33%][KOG0124:67%][.KOG0120:33%]
Bilateria@ENSCSAVP00000007991[62][RRM2:95%****][.RRM1:5%*][UMH:74%***][KOG0124:100%****]Phaeodactylum tricornutum@jgi_Phatr2_44442[RRM2][KOG4211]
Thalassiosira pseudonana@jgi_Thaps3_1374[RRM2][KOG0116]Phytophthora@jgi_Physo1_1_136329[2][RRM2:100%][KOG0123:100%]
Aureococcus anophagefferens@jgi_Auran1_8214[RRM1]Volvox carteri@jgi_Volca1_120369[RRM1][put-sr][KOG0147]
Euteleostomi@ENSMODP00000021210[32][RRM2:97%***][nucleolin:59%**][KOG0123:100%***]Ciona@ENSCINP00000008105[4][RRM1:100%*][KOG0116:50%][.KOG2141:25%]
Magnoliophyta@30131_m007093[6][RRM3:83%*][.RRM2:17%][KOG0127:100%*]Physcomitrella patens@jgi_Phypa1_1_201182[RRM3][KOG0127]
Dictyostelium discoideum_AX4@XP_646584[RRM3][KOG0127]Ostreococcus@jgi_Ostta4_19569[2][RRM3:100%][KOG0127:100%]
Chlamydomonadales@jgi_Volca1_87629[2][RRM3:100%][KOG0127:100%]Caenorhabditis elegans@B0035_12_2[2][RRM2:100%][KOG0128:100%]Ciona intestinalis@ENSCINP00000018774[2][RRM3:100%][KOG0127:100%]
Euteleostomi@ENSGACP00000016696[19][RRM3:79%**][.RRM4:11%][.RRM1:11%][RBM:58%**][KOG0127:100%**]Oryzias latipes@ENSORLP00000012079[RRM3][KOG0127]
Caenorhabditis elegans@R05H10_2[RRM2][KOG0127]Endopterygota@XP_001605703[3][RRM2:67%][.RRM3:33%][KOG0127:100%*]
Drosophila melanogaster@CG4806-PA[RRM2][KOG0127]Schizosaccharomyces pombe_972h-@NP_596518[RRM1][KOG0116]
Aedes aegypti@AAEL008572-PA[RRM2][KOG0127]Leishmania infantum_JPCM5@XP_001464648[RRM1][KOG0113]
Coxiella_burnetii@YP_001424503[2][RRM1:100%][PROK:100%][KOG0113:100%]Cryptosporidium parvum_Iowa_II@XP_627799[RRM2][KOG0110]
Chlamydomonas reinhardtii@jgi_Chlre3_120019[RRM2][KOG0106]Chlamydomonas reinhardtii@jgi_Chlre3_80366[RRM2][KOG0106]
Embryophyta@29742_m001371[15][RRM2:80%**][.RRM1:20%*][put-sr:87%**][SR:67%**][KOG0106:100%**]Bacillariophyta@jgi_Phatr2_47737[2][RRM1:100%][put-sr:50%]
Cryptosporidium parvum_Iowa_II@XP_628165[RRM2][KOG4212]Dictyostelium discoideum_AX4@XP_639372[RRM1][KOG0670]
Embryophyta@NP_001062111[8][RRM1:100%**][put-sr:62%*][KOG4849:38%*][.KOG4246:12%][.KOG0113:12%][.KOG4676:12%]Ostreococcus lucimarinus@jgi_Ost9901_3_26750[RRM1]
Dictyostelium discoideum_AX4@XP_629950[RRM1][KOG0128]Ciona intestinalis@ENSCINP00000019833[3][RRM2:100%*][KOG0128:100%*]
Culicidae@AAEL011963-PA[3][RRM2:100%*][KOG0128:100%*]Strongylocentrotus purpuratus@XP_781643[RRM2][KOG0128]
Tribolium castaneum@XP_972538[RRM2][KOG0128]Euteleostomi@ENSOCUP00000014007[29][RRM2:97%***][SART3:69%**][KOG0128:100%***]
Apocrita@XP_001602582[2][RRM2:100%][KOG0128:100%]Eukaryota@jgi_Ostta4_3181[66][RRM1:100%****][put-sr:47%***][cyclophilin:32%***][KOG0415:97%****]
Debaryomyces hansenii_CBS767@XP_459815[RRM1][KOG0415]Yarrowia lipolytica@XP_503802[RRM1][KOG0113]
Saccharomycetaceae@XP_001385249[2][RRM1:100%][KOG0113:100%]Saccharomycetales@NP_984033[3][RRM1:100%*][KOG0113:100%*]Kluyveromyces lactis@XP_452557[RRM1][KOG0113]
Phytophthora@jgi_Phyra1_1_44765[2][RRM1:100%][put-sr:50%][KOG0113:100%]Embryophyta@29657_m000467[4][RRM1:100%*][put-sr:50%][snRNP:25%][KOG0113:100%*]
Tribolium castaneum@XP_966565[RRM1][KOG0113]Deuterostomia@XP_001178221[30][RRM1:100%***][put-sr:63%**][snRNP:70%***][KOG0113:100%***]
Ciona@ENSCSAVP00000001345[2][RRM1:100%][KOG0113:100%]Schizosaccharomyces pombe_972h-@NP_593779[RRM1][KOG0113]
Sordariomycetes@XP_959061[2][RRM1:100%][KOG0113:100%]Aspergillus fumigatus_Af293@XP_753306[RRM1][KOG0113]
Coelomata@AAEL011340-PB[2][RRM1:100%][put-sr:50%][KOG0113:100%]Rattus norvegicus@ENSRNOP00000048879[RRM1][snRNP][KOG0113]
Felis catus@ENSFCAP00000006212[RRM1][put-sr][KOG0113]Ostreococcus@jgi_Ostta4_11066[2][RRM1:100%][KOG0113:100%]Eukaryota@jgi_Physo1_1_143842[43][RRM1:100%***][put-sr:47%**][snRNP:14%*][KOG0113:100%***]
Cryptosporidium parvum_Iowa_II@XP_627471[RRM1][KOG0113]Aureococcus anophagefferens@jgi_Auran1_34517[2][RRM1:100%][put-sr:50%][KOG0113:100%]
Culicidae@AAEL004075-PA[3][RRM5:67%][.RRM1:33%][KOG0110:100%*]Dictyostelium discoideum_AX4@XP_646584[RRM2][KOG0127]
Phytophthora sojae@jgi_Physo1_1_132702[RRM4][KOG0127]Phytophthora ramorum@jgi_Phyra1_1_79608[2][RRM4:100%][KOG0127:100%]
Strongylocentrotus purpuratus@XP_783689[2][RRM2:100%][KOG0127:100%]Saccharomycetales@XP_001385462[7][RRM3:100%*][KOG0127:100%*]
Sordariomycetes@XP_962933[2][RRM3:100%][KOG0127:100%]Aspergillus fumigatus_Af293@XP_752199[RRM3][KOG0127]
Basidiomycota@XP_756663[3][RRM4:67%][.RRM3:33%][KOG0127:100%*]Schizosaccharomyces pombe_972h-@NP_596114[RRM3][KOG0127]
Phaeodactylum tricornutum@jgi_Phatr2_8457[RRM1][KOG0122]Ciona savignyi@ENSCSAVP00000001587[RRM5][KOG4307]
Caenorhabditis elegans@Y73B6BL_33[RRM1][KOG4211]Physcomitrella patens@jgi_Phypa1_1_162342[RRM3][KOG1365]
Thalassiosira pseudonana@jgi_Thaps3_5686[RRM2][KOG4211]Arabidopsis thaliana@NP_188725[RRM2][hnRNP][KOG1365]
Volvox carteri@jgi_Volca1_117772[RRM1][KOG1365]Plasmodium falciparum_3D7@XP_001347519[RRM1][KOG1365]
Coelomata@ENSCINP00000003632[126][RRM2:70%****][.RRM1:30%***][hnRNP:37%***][.GRSRBP:15%**][KOG4211:100%****]Danio rerio@ENSDARP00000069459[RRM2][KOG4211]
Oryzias latipes@ENSORLP00000025180[RRM2][put-sr][KOG4307]Caenorhabditis elegans@W02D3_11b[2][RRM1:100%][KOG4211:100%]
Phytophthora@jgi_Physo1_1_132702[3][RRM3:100%*][KOG0127:100%*]Caenorhabditis elegans@C18D11_4_1[2][RRM1:100%][put-sr:100%][KOG0921:100%]
Coelomata@AGAP006798-PA[81][RRM1:100%****][put-sr:99%****][KOG0122:26%***][.KOG0125:25%**][.KOG0147:14%**][.KOG0108:9%*]Basidiomycota@XP_757472[3][RRM1:100%*][put-sr:33%][KOG0122:33%]
Dictyostelium discoideum_AX4@XP_642304[RRM1][KOG0415]Aedes aegypti@AAEL004293-PA[RRM1][put-sr]
Drosophila melanogaster@CG10128-PC[6][RRM1:100%*][put-sr:100%*]Eutheria@ENSMLUP00000005283[2][RRM1:100%][put-sr:100%]
Spermophilus tridecemlineatus@ENSSTOP00000006011[RRM1][put-sr]Saccharomycetales@NP_986417[7][RRM1:100%*][KOG0127:100%*]
Schizosaccharomyces pombe_972h-@NP_596114[RRM1][KOG0127]Basidiomycota@XP_568669[3][RRM1:100%*][KOG0127:100%*]Sordariomycetes@XP_382687[2][RRM1:100%][KOG0127:100%]
Aspergillus fumigatus_Af293@XP_752199[RRM1][KOG0127]Euteleostomi@ENSOANP00000001262[28][RRM1:100%***][RBM:46%**][KOG0127:100%***]
Dictyostelium discoideum_AX4@XP_646584[RRM1][KOG0127]Chlamydomonadales@jgi_Chlre3_186870[2][RRM1:100%][KOG0127:100%]
Magnoliophyta@NP_565513[6][RRM1:100%*][KOG0127:100%*]Physcomitrella patens@jgi_Phypa1_1_201182[RRM1][KOG0127]
Saccharomycetaceae@XP_458658[2][RRM1:100%][KOG0921:100%]Phytophthora@jgi_Physo1_1_132702[3][RRM1:100%*][KOG0127:100%*]
Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM2][KOG0110]Thalassiosira pseudonana@jgi_Thaps3_268689[RRM2][KOG0110]
eurosids_I@IMGA_CT963106_6_1[2][RRM1:100%][KOG0117:50%]Arabidopsis thaliana@NP_567594[RRM1][KOG0117]
Phytophthora@jgi_Physo1_1_129427[2][RRM2:100%][KOG0110:100%]Neurospora crassa_OR74A@XP_965014[RRM2][KOG0110] PSf
31
70 - RBM
80 - hnRNP
39
38 - Cyclophilin
37 - SART3
36 - snRNP
56 - green plant-specific
RS group of SR proteins
72 - RBM
67 - UMH
Fig. S7
99
74
80
63
83
52
88
55
86
97
69
73
70
57
66 70
75
58
73
84 98
Schizosaccharomyces pombe 972h @NP 594970[RRM2][KOG4210]Saccharomycetales@NP_982813[6][RRM2:100%*][KOG4210:100%*]
Aspergillus fumigatus_Af293@XP_755020[RRM2]Schizosaccharomyces pombe_972h-@NP_596033[RRM1]
Apocrita@XP_001602363[2][RRM1:100%][KOG1832:50%]Culicidae@AAEL001997-PA[2][RRM1:100%]
Drosophila melanogaster@CG3594-PA[RRM1][KOG0110]Sordariomycetes@XP_389032[2][RRM1:100%]
Neurospora crassa_OR74A@XP_964518[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_570477[RRM1]
Phytophthora@jgi_Physo1_1_136292[2][RRM1:100%]Phaeodactylum tricornutum@jgi_Phatr2_32836[RRM1]
Neurospora crassa_OR74A@XP_965346[RRM2][KOG0110]Aspergillus fumigatus_Af293@XP_747328[RRM2][KOG0110]
Ustilago maydis_521@XP_762237[RRM1]Schizosaccharomyces pombe_972h-@NP_595728[RRM1]
Sordariomycetes@XP_956776[2][RRM1:100%][put-sr:50%]Aspergillus fumigatus_Af293@XP_755976[RRM1]Coelomata@XP_001182806[39][RRM1:100%***][KOG0108:13%*][.KOG0116:8%*][.KOG0921:5%]
Yarrowia lipolytica@XP_504609[RRM1]Pichia stipitis_CBS_6054@XP_001384729[RRM1]
Phytophthora@jgi_Phyra1_1_83430[2][RRM1:100%]Ciona@ENSCSAVP00000001842[2][RRM1:100%]
Euteleostomi@ENSSARP00000000775[28][RRM1:100%***][eIF4B:54%**]Drosophila melanogaster@CG10837-PA[3][RRM1:100%*]
Anopheles gambiae@AGAP000525-PA[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_569209[RRM2][KOG0144]
Theileria parva_strain_Muguga@XP_765374[RRM1]Cryptosporidium parvum_Iowa_II@XP_001388131[RRM1][KOG1015]
Embryophyta@28180_m000395[3][RRM1:100%*][KOG0124:100%*]Arabidopsis thaliana@NP_191094[RRM1][KOG4205]
Phaeodactylum tricornutum@jgi_Phatr2_49387[RRM1]Ostreococcus lucimarinus@jgi_Ost9901_3_92667[RRM1]
Aureococcus anophagefferens@jgi_Auran1_9434[RRM1]Magnoliophyta@NP_001053909[5][RRM1:100%*][nucleolin:40%][KOG0123:40%][.KOG4210:40%][.KOG1015:20%]
Ostreococcus@jgi_Ostta4_33150[2][RRM2:100%][KOG0108:50%]Phytophthora@jgi_Physo1_1_141766[2][RRM2:100%][KOG0148:100%]
Embryophyta@28180_m000395[6][RRM2:100%*][KOG0124:50%*][.KOG4205:33%][.KOG4211:17%]stramenopiles@jgi_Auran1_17857[4][RRM1:50%][.RRM2:50%][KOG0108:50%][.KOG4205:50%]
Ostreococcus tauri@jgi_Ostta4_32569[RRM2]Aureococcus anophagefferens@jgi_Auran1_64341[RRM2][KOG0108]Ostreococcus@jgi_Ost9901_3_7913[3][RRM1:100%*][KOG0131:33%]Leishmania infantum_JPCM5@XP_001466413[RRM2][put-sr][KOG0147]
Physcomitrella patens@jgi_Phypa1_1_93324[RRM1]Ostreococcus tauri@jgi_Ostta4_10328[RRM1][KOG2476]
Arabidopsis thaliana@NP_175125[7][RRM1:43%*][.RRM2:29%][.RRM4:14%][.RRM3:14%][PABP:29%][KOG0123:100%*]Ostreococcus tauri@jgi_Ostta4_34258[RRM2]
Phytophthora@jgi_Phyra1_1_77488[2][RRM1:100%][KOG4205:100%]Phytophthora sojae@jgi_Physo1_1_139998[RRM1]
Physcomitrella patens@jgi_Phypa1_1_188347[RRM2][KOG0123]Physcomitrella patens@jgi_Phypa1_1_167900[RRM2][KOG1015]
Magnoliophyta@29675_m000389[3][RRM2:100%*][KOG0123:67%][.KOG1015:33%]Arabidopsis thaliana@NP_188491[RRM2][nucleolin][KOG4210]Phytophthora@jgi_Phyra1_1_76845[2][RRM1:100%][KOG0123:100%]
Phaeodactylum tricornutum@jgi_Phatr2_44442[RRM1][KOG4211]Dictyostelium discoideum_AX4@XP_643642[RRM2][KOG0148]
Cryptosporidium parvum_Iowa_II@XP_001388131[RRM2][KOG1015]Yarrowia lipolytica@XP_504884[RRM3][KOG0123]
Thalassiosira pseudonana@jgi_Thaps3_24369[RRM1]Plasmodium falciparum_3D7@XP_966051[RRM1]
Encephalitozoon cuniculi_GB-M1@XP_965888[RRM1][KOG4209]Theileria parva_strain_Muguga@XP_765374[RRM2]
Pichia stipitis_CBS_6054@XP_001384763[RRM3][KOG0123]Phaeodactylum tricornutum@jgi_Phatr2_44395[RRM1]Poaceae@8373_m000321_c0161G04[2][RRM1:100%][KOG4205:50%][.KOG4211:50%]
Volvox carteri@jgi_Volca1_90315[RRM1]Apocrita@XP_001602582[2][RRM1:100%][KOG0128:100%]Strongylocentrotus purpuratus@XP_001180991[4][RRM1:100%*]
Ostreococcus@jgi_Ost9901_3_31221[2][RRM1:100%][KOG0128:100%]Magnoliophyta@29609_m000574[4][RRM1:100%*][KOG0128:100%*]
Physcomitrella patens@jgi_Phypa1_1_135986[RRM1][KOG0128]Cyanidioschyzon merolae@gnl_CMER_CMO334C[RRM2][KOG0126]
Ascomycota@XP_505055[6][RRM1:83%*][.RRM2:17%]Culicidae@AGAP003171-PA[3][RRM2:100%*][KOG0148:33%]
Drosophila melanogaster@CG12288-PA[RRM2]Trypanosomatidae@XP_827554[2][RRM1:50%][.RRM2:50%][put-sr:50%]
Apis mellifera@XP_394565[RRM2][KOG0147]Coelomata@ENSDARP00000093407[32][RRM2:88%***][.RRM1:12%*][KOG0108:12%*][.KOG3001:6%][.KOG0123:6%][.KOG0126:6%]
Phaeodactylum tricornutum@jgi_Phatr2_46145[RRM2]Dictyostelium discoideum_AX4@XP_635997[RRM2]
Caenorhabditis elegans@F11A10_7[RRM2][KOG0131]Magnoliophyta@30054_m000807[2][RRM2:100%][KOG1267:50%]Ostreococcus@jgi_Ostta4_30189[2][RRM1:50%][.RRM2:50%][put-sr:50%]
Volvox carteri@jgi_Volca1_118759[RRM2]Trypanosomatidae@XP_847474[2][RRM1:100%]
Trypanosomatidae@XP_001467105[2][RRM1:100%][KOG4209:100%]Saccharomycetaceae@XP_453677[2][RRM1:100%][KOG4209:100%]
Saccharomyces cerevisiae@YIR001C[RRM1][PABP][KOG4209]Candida glabrata_CBS138@XP_447800[RRM1][KOG4209]
Eukaryota@ENSCSAVP00000003369[89][RRM1:100%****][put-sr:17%**][PABP:26%***][KOG4209:100%****]Dictyostelium discoideum_AX4@XP_642788[RRM1][KOG4209]
Caenorhabditis elegans@T08B6_5[RRM1][KOG4209]Caenorhabditis elegans@EEED8_12[2][RRM1:100%][KOG4209:100%]
Ciona@ENSCSAVP00000010162[2][RRM1:100%][KOG4209:100%]Magnoliophyta@IMGA_AC160842_25_1[6][RRM1:100%*][KOG3702:83%*][.KOG4209:17%]
Physcomitrella patens@jgi_Phypa1_1_167236[RRM1][KOG4209]Volvox carteri@jgi_Volca1_103724[RRM1][put-sr][KOG0591]
Arabidopsis thaliana@NP_180012[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_10122[RRM1][KOG0153]
Schizosaccharomyces pombe_972h-@NP_595190[RRM1][KOG0111]Ornithorhynchus anatinus@ENSOANP00000022523[3][RRM1:67%][.RRM2:33%][KOG2248:100%*]
Cryptococcus neoformans_var._neoformans_JEC21@XP_566572[RRM1][KOG0111]Euteleostomi@ENSMODP00000018834[25][RRM1:100%***][put-sr:64%**][KOG0147:48%**][.KOG0132:12%*]
Tribolium castaneum@XP_971953[RRM1]Strongylocentrotus purpuratus@XP_001185731[2][RRM1:100%]
Pezizomycotina@XP_755630[3][RRM1:100%*][KOG0111:100%*]Phytophthora ramorum@jgi_Phyra1_1_76171[2][RRM1:100%][KOG0111:100%]
Thalassiosira pseudonana@jgi_Thaps3_31121[RRM1][KOG0111]Phaeodactylum tricornutum@jgi_Phatr2_11308[RRM1][KOG0111]
Theileria parva_strain_Muguga@XP_765867[RRM1][KOG0111]Plasmodium falciparum_3D7@XP_001349948[RRM1][KOG0111]
Eukaryota@ENSGALP00000021793[59][RRM1:100%****][cyclophilin:59%***][KOG0111:98%****]Eutheria@ENSEEUP00000009324[3][RRM1:100%*][cyclophilin:100%*][KOG0111:100%*]Otolemur garnettii@ENSOGAP00000003225[RRM1][KOG0111]Phytophthora@jgi_Phyra1_1_94266[2][RRM2:100%][KOG0147:100%]
Ascomycota@XP_385341[4][RRM2:100%*][put-sr:100%*][KOG0147:100%*]Plasmodium falciparum_3D7@XP_001349956[RRM2][KOG0147]
Cryptococcus neoformans_var._neoformans_JEC21@XP_571060[RRM2][KOG0147]Yarrowia lipolytica@XP_504318[RRM2][KOG0147]
Ustilago maydis_521@XP_756311[RRM2][put-sr][KOG0147]
19 - Cyclophilin
83 - PABP
74
87 - eIF-4B
Fig. S7
100
61
65
64
93
86
54
92
61
79
88 53
69
63
54 58
64
53
90
Arabidopsis thaliana@NP 192643[2][RRM2:100%][KOG0110:100%]Yarrowia lipolytica@XP_505184[RRM1]
Chlamydomonadales@jgi_Volca1_90315[3][RRM2:67%][.RRM3:33%][KOG0123:67%]Aureococcus anophagefferens@jgi_Auran1_6342[RRM2][KOG0123]
Trypanosomatidae@XP_001465100[2][RRM2:100%][KOG4212:100%]Saccharomycetales@XP_446962[5][RRM1:100%*][put-sr:60%*][KOG0127:60%*][.KOG0123:40%]
Saccharomycetaceae@XP_462023[2][RRM1:100%][put-sr:100%][KOG0123:100%]Dikarya@XP_568231[5][RRM3:100%*][put-sr:80%*][KOG4212:80%*][.KOG0147:20%]
Yarrowia lipolytica@XP_503927[RRM3][put-sr][KOG4212]Saccharomycetales@XP_888678[3][RRM3:67%][.RRM2:33%][put-sr:67%][KOG0123:67%][.KOG4212:33%]
Saccharomycetales@YNL004W[4][RRM3:100%*][put-sr:50%][KOG0123:50%][.KOG0127:50%]Kluyveromyces lactis@XP_453283[RRM2][KOG0123]
Theileria parva_strain_Muguga@XP_764636[RRM1]Plasmodium falciparum_3D7@XP_966143[RRM1][KOG0533]
Yarrowia lipolytica@XP_505140[RRM1][KOG0533]Pezizomycotina@XP_958422[3][RRM1:100%*][put-sr:33%][KOG0533:100%*]
Ustilago maydis_521@XP_757147[RRM1][KOG0533]Eukaryota@GSTENP00007343001[69][RRM1:100%****][FCAFPA:10%*][KOG0533:99%****]
Ostreococcus tauri@jgi_Ostta4_36431[RRM1][KOG0533]Chlamydomonadales@jgi_Volca1_90392[2][RRM1:100%][KOG0533:100%]
Dictyostelium discoideum_AX4@XP_638266[RRM1][KOG0533]Phytophthora@jgi_Phyra1_1_97175[2][RRM1:100%][put-sr:50%][KOG0533:100%]
Cyanidioschyzon merolae@gnl_CMER_CMH135C[RRM1]Euteleostomi@ENSTBEP00000009485[3][RRM1:100%*][PDIP:33%][KOG0533:33%]Endopterygota@CG6961-PA[7][RRM1:100%*][KOG0533:29%]
Coelomata@ENSMLUP00000006206[100][RRM2:88%****][.RRM1:12%**][put-sr:5%*][hnRNP:28%***][KOG4212:98%****]Caenorhabditis elegans@C25A1_4_2[2][RRM2:100%][put-sr:100%][KOG4212:100%]
Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM2][KOG4212]Eukaryota@jgi_Volca1_109965[18][RRM1:78%**][.RRM2:22%*][put-sr:22%*][KOG4212:61%**][.KOG0123:39%*]
Trypanosomatidae@XP_001465100[2][RRM1:100%][KOG4212:100%]Chlamydomonadales@jgi_Chlre3_184854[2][RRM1:100%][KOG0055:50%]
Bacillariophyta@jgi_Phatr2_7426[2][RRM1:100%]Trypanosoma brucei_TREU927@XP_823301[RRM1][KOG0921]
Phytophthora@jgi_Physo1_1_136493[2][RRM2:100%][put-sr:100%][KOG0105:100%]Phytophthora ramorum@jgi_Phyra1_1_84100[RRM2][KOG0105]
Fungi/Metazoa_group@AGAP004592-PA[123][RRM2:81%****][.RRM1:18%***][put-sr:100%****][SR:60%****][KOG0105:50%****][.KOG0106:46%****]Bilateria@XP_967263[73][RRM2:78%****][.RRM1:22%**][put-sr:79%****][SR:75%****][KOG0105:100%****]
Theileria parva_strain_Muguga@XP_766386[RRM2][put-sr][KOG0105]Plasmodium falciparum_3D7@XP_001347501[RRM2][put-sr][KOG0105]
Phytophthora@jgi_Phyra1_1_75500[2][RRM3:100%][KOG0123:100%]Thalassiosira pseudonana@jgi_Thaps3_37126[RRM2][KOG0123]
Phaeodactylum tricornutum@jgi_Phatr2_51303[RRM2][KOG4212]Chlamydomonadales@jgi_Volca1_78979[2][RRM1:100%][KOG3070:100%]
Volvox carteri@jgi_Volca1_109965[RRM2][KOG4212]Strongylocentrotus purpuratus@XP_786244[2][RRM3:100%][put-sr:100%][KOG4212:100%]
Endopterygota@CG9373-PA[4][RRM3:100%*][KOG4212:100%*]Chordata@ENSOGAP00000002890[91][RRM3:80%****][.RRM2:13%**][.RRM1:7%*][hnRNP:37%***][KOG4212:100%****]
Cyanidioschyzon merolae@gnl_CMER_CMM078C[RRM2][KOG4212]Saccharomycetales@XP_001386572[3][RRM2:67%][.RRM1:33%][put-sr:67%][KOG0123:67%][.KOG4212:33%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572539[4][RRM2:100%*][KOG4212:100%*]Saccharomycetaceae@XP_453283[2][RRM1:50%][.RRM2:50%][KOG0123:50%][.KOG0127:50%]
Saccharomyces cerevisiae@YNL004W[RRM2][KOG0127]Saccharomycetales@XP_445179[2][RRM2:100%][put-sr:100%][KOG0123:100%]
Candida glabrata_CBS138@XP_446962[RRM2][put-sr][KOG0127]Basidiomycota@XP_758699[7][RRM1:71%*][.RRM2:29%][put-sr:14%][KOG4212:100%*]
Schizosaccharomyces pombe_972h-@NP_594207[RRM2][KOG4212]Plasmodium falciparum_3D7@XP_001347353[RRM2][KOG4212]
Pezizomycotina@XP_751108[2][RRM2:100%][put-sr:100%][KOG4212:100%]Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM2][put-sr][KOG0147]
Theileria parva_strain_Muguga@XP_765501[RRM1][KOG0127]Kluyveromyces lactis@XP_451368[RRM3][KOG0123]
Ashbya gossypii_ATCC_10895@NP_984845[RRM3][KOG0123]Saccharomyces cerevisiae@YHR015W[RRM3][KOG0123]
Saccharomyces cerevisiae@YFR023W[RRM3][KOG0123]Candida glabrata_CBS138@XP_447635[RRM3][KOG0123]
Trypanosomatidae@XP_001463723[2][RRM1:100%][KOG0110:100%]Drosophila melanogaster@CG2050-PA[RRM2]
Encephalitozoon cuniculi_GB-M1@NP_597583[RRM1][KOG4205]Pichia stipitis_CBS_6054@XP_001387063[RRM1]
Encephalitozoon cuniculi_GB-M1@NP_597583[RRM2][KOG4205]Saccharomycetales@YHL034C[2][RRM1:100%]
Kluyveromyces lactis@XP_453971[RRM1]Percomorpha@ENSGACP00000007987[5][RRM1:100%*][IGF2BP:80%*][KOG2193:100%*]
rosids@30155_m001644[2][RRM1:100%][KOG0116:50%]Physcomitrella patens@jgi_Phypa1_1_12664[RRM1]
Theileria parva_strain_Muguga@XP_766553[RRM1][KOG4208]Cyanidioschyzon merolae@gnl_CMER_CMI122C[RRM1][KOG4208]
Thalassiosira pseudonana@jgi_Thaps3_18198[RRM1][KOG4208]Phaeodactylum tricornutum@jgi_Phatr2_45356[RRM1][KOG4208]
Dictyostelium discoideum_AX4@XP_643547[RRM1]Caenorhabditis elegans@T04A8_6[RRM1][KOG4208]
Eukaryota@CG6937-PA[73][RRM1:100%****][put-sr:5%*][KOG4208:99%****]Anopheles gambiae@AGAP006090-PA[RRM1]
Trypanosoma brucei_TREU927@XP_845742[RRM1][KOG0126]Saccharomycetaceae@XP_459205[2][RRM1:100%][KOG0126:100%]
Eukaryota@AAEL002461-PA[78][RRM1:100%****][put-sr:29%***][KOG0126:100%****]Ustilago maydis_521@XP_760864[RRM1][KOG0126]Chlamydomonadales@jgi_Volca1_120471[2][RRM1:100%][KOG0108:100%]
Dictyostelium discoideum_AX4@XP_640243[RRM1][KOG0117]Oryza sativa_japonica_cultivar-group@NP_001064224[RRM1][KOG0117]
Ricinus communis@30072_m000974[RRM1][KOG0117]Magnoliophyta@29709_m001182[6][RRM1:100%*][put-sr:17%][KOG0117:100%*]
Physcomitrella patens@jgi_Phypa1_1_140180[3][RRM1:100%*][KOG0117:100%*]Endopterygota@XP_624681[6][RRM1:100%*][put-sr:17%][KOG0921:67%*][.KOG1548:33%]
Euteleostomi@ENSDARP00000069729[82][RRM1:100%****][KOG1995:77%****][.KOG0921:16%**][.KOG2044:5%*]Strongylocentrotus purpuratus@XP_001196853[2][RRM1:100%][KOG1995:100%]
Arabidopsis thaliana@NP_564565[RRM1][put-sr][KOG1995]Caenorhabditis elegans@R09B3_3[3][RRM1:100%*][KOG0108:100%*]
Ciona savignyi@ENSCSAVP00000008315[4][RRM1:100%*][KOG0108:100%*]Geobacter uraniumreducens_Rf4@YP_001230384[RRM1][PROK][KOG0108]
Synechococcus@YP_473618[2][RRM1:100%][PROK:100%][KOG0108:100%]Chlamydomonas reinhardtii@jgi_Chlre3_181993[RRM1]
Ustilago maydis_521@XP_758493[RRM2][KOG0110]Aureococcus anophagefferens@jgi_Auran1_1296[RRM1][KOG0110]
Oryza sativa_japonica_cultivar-group@NP_001058465[RRM1][KOG0108]Saccharomycetaceae@XP_001383390[2][RRM1:100%][KOG0108:100%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572946[RRM1][KOG0108]Bacillariophyta@jgi_Phatr2_8451[2][RRM1:100%][KOG0108:100%]
Aureococcus anophagefferens@jgi_Auran1_23269[RRM1][KOG0108]Cryptosporidium parvum_Iowa_II@XP_627975[RRM1][KOG0108]
Theileria parva_strain_Muguga@XP_766096[RRM1]Plasmodium falciparum_3D7@XP_001352196[RRM1][KOG0108]
Thalassiosira pseudonana@jgi_Thaps3_263845[RRM1][KOG0108]Aureococcus anophagefferens@jgi_Auran1_17171[RRM1][KOG0108]
Eukaryota@ENSDARP00000064611[84][RRM1:100%****][KOG0108:99%****]Ostreococcus tauri@jgi_Ostta4_31925[RRM1][KOG0117]
Encephalitozoon cuniculi_GB-M1@NP_597167[RRM1][KOG0108]Chlamydomonadales@jgi_Volca1_54847[2][RRM1:100%][KOG0108:100%]
Yarrowia lipolytica@XP_499736[RRM2][KOG4205]Schizosaccharomyces pombe_972h-@NP_594970[RRM2][KOG4210]
62
69
87 - eIF-4B
48 - IGF2BP
29 - dual-RRM
SR proteins
30 - hnRNP
PDIP
FCA FPA
Fig. S7
101
0.20
59
99
71
61 79
66
69
91 81
60
81
51
67
83
74
87 69
61
Ostreococcus tauri@jgi_Ostta4_19468[RRM1][KOG0127]cellular_organisms@YP_001113853[137][RRM1:100%****][PROK:99%****][KOG0108:58%****][.KOG0116:14%**][.KOG0921:7%**][.KOG0149:7%**][.KOG0111:6%**]
Carboxydothermus hydrogenoformans_Z-2901@YP_359251[RRM1][PROK][KOG0108]Syntrophobacter fumaroxidans_MPOB@YP_844222[RRM1][PROK][KOG0108]Campylobacter@YP_001467322[2][RRM1:100%][PROK:100%][KOG0148:100%]
Bacteroidales@YP_213478[13][RRM1:100%**][PROK:100%**][KOG0108:69%**][.KOG0125:31%*]Bacteroides@YP_001298723[3][RRM1:100%*][PROK:100%*][KOG0108:100%*]Bacteroidales@YP_001302325[2][RRM1:100%][PROK:100%][KOG0123:50%][.KOG0122:50%]
Treponema pallidum_subsp._pallidum_str._Nichols@NP_218796[RRM1][PROK][KOG0149]Methanomicrobiales@YP_503016[5][RRM1:100%*][PROK:100%*][KOG0108:40%][.KOG0125:20%][.KOG0116:20%]
Nitrosococcus oceani_ATCC_19707@YP_344746[RRM1][PROK][KOG0148]Theileria parva_strain_Muguga@XP_766728[RRM2][KOG0124]
Plasmodium falciparum_3D7@XP_001347332[RRM2][put-sr][KOG0105]Percomorpha@ENSGACP00000011877[6][RRM1:100%*][KOG0123:100%*]
Gallus gallus@ENSGALP00000012472[2][RRM1:100%][KOG0123:100%]Syntrophobacter fumaroxidans_MPOB@YP_845575[RRM1][PROK]
Candidatus Protochlamydia_amoebophila_UWE25@YP_007892[RRM1][PROK][KOG0149]Leptospira@YP_000459[4][RRM1:100%*][PROK:100%*][KOG0108:100%*]
Gammaproteobacteria@YP_001083500[11][RRM1:100%**][PROK:100%**][KOG0145:27%*][.KOG0108:18%][.KOG0144:9%][.KOG0122:9%]Vibrio fischeri_ES114@YP_206444[RRM1][PROK][KOG0145]
Alkalilimnicola ehrlichei_MLHE-1@YP_741458[RRM1][PROK]Cyanobacteria@YP_476186[8][RRM1:100%**][PROK:100%**][KOG0108:38%*][.KOG0122:12%]
Synechococcus_elongatus@YP_399809[2][RRM1:100%][PROK:100%][KOG0108:100%]Cyanobacteria@NP_898344[17][RRM1:100%**][PROK:100%**][KOG0108:65%**]
Gammaproteobacteria@YP_561253[27][RRM1:100%***][PROK:100%***][KOG0108:96%***]Neurospora crassa_OR74A@XP_958552[RRM3][KOG0128]
Schizosaccharomyces pombe_972h-@NP_596721[RRM3][KOG0128]Aspergillus fumigatus_Af293@XP_749317[RRM3][KOG0128]
Pezizomycotina@XP_749317[2][RRM2:100%][KOG0128:100%]Schizosaccharomyces pombe_972h-@NP_596721[RRM2][KOG0128]
Saccharomyces cerevisiae@YMR268C[RRM2][KOG0128]Debaryomyces hansenii_CBS767@XP_460681[RRM2][KOG0128]
Plasmodium falciparum_3D7@XP_001350574[RRM3][KOG0110]Eukaryota@NP_001053839[55][RRM6:42%***][.RRM5:35%**][.RRM4:11%*][.RRM3:9%*][KOG0110:100%****]
Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM5][KOG0110]Encephalitozoon cuniculi_GB-M1@NP_597181[RRM3][KOG0110]
Cryptosporidium parvum_Iowa_II@XP_627799[RRM5][KOG0110]Tribolium castaneum@XP_971197[RRM1][KOG4661]Coelomata@ENSTBEP00000011040[87][RRM1:98%****][put-sr:16%**][KOG4661:100%****]
Tribolium castaneum@XP_969134[RRM1]Caenorhabditis elegans@ZC404_8_2[2][RRM1:100%][KOG0125:100%]
Bilateria@ENSORLP00000014121[125][RRM1:100%****][FOX:75%****][KOG0125:100%****]Felis catus@ENSFCAP00000007638[RRM1][KOG0125]
Phytophthora@jgi_Physo1_1_137237[2][RRM1:100%][put-sr:100%][KOG0125:50%][.KOG0148:50%]Plasmodium falciparum_3D7@XP_001347313[RRM1][KOG0127]
Embryophyta@jgi_Phypa1_1_28366[17][RRM1:100%**][put-sr:76%**][KOG0127:29%*][.KOG0125:12%][.KOG4661:6%][.KOG0147:6%]Schizosaccharomyces pombe_972h-@NP_001018280[RRM1][KOG0145]
Cryptococcus neoformans_var._neoformans_JEC21@XP_570425[RRM1][put-sr][KOG0145]Pezizomycotina@XP_960722[3][RRM1:100%*][put-sr:33%][KOG0113:33%]
Yarrowia lipolytica@XP_499712[RRM1][KOG0145]Ciona intestinalis@ENSCINP00000019832[3][RRM1:100%*][KOG0128:100%*]
Culicidae@AAEL011961-PA[3][RRM1:100%*][KOG0128:100%*]Tribolium castaneum@XP_972538[RRM1][KOG0128]
Euteleostomi@ENSSTOP00000002132[31][RRM1:100%***][SART3:68%***][KOG0128:100%***]Strongylocentrotus purpuratus@XP_781643[RRM1][KOG0128]
Ciona intestinalis@ENSCINP00000023563[RRM1][KOG0108]Coelomata@ENSOGAP00000009767[86][RRM1:100%****][hnRNP:34%***][KOG4212:100%****]
Strongylocentrotus purpuratus@XP_001187716[4][RRM1:100%*][put-sr:100%*][KOG4212:50%][.KOG4661:50%]Encephalitozoon cuniculi_GB-M1@NP_585962[RRM2][KOG0123]
Dictyostelium discoideum_AX4@XP_001134510[RRM4][KOG0123]Strongylocentrotus purpuratus@XP_001198098[2][RRM1:100%][put-sr:100%][KOG0147:100%]
Phytophthora@jgi_Physo1_1_157186[2][RRM1:100%][KOG0147:100%]Dictyostelium discoideum_AX4@XP_638966[RRM1][KOG0147]
Eukaryota@ENSMLUP00000011758[47][RRM1:100%***][put-sr:91%***][UMH:64%***][.CAPER:15%*][KOG0147:100%***]Ascomycota@NP_594422[4][RRM1:100%*][put-sr:100%*][KOG0147:100%*]
Yarrowia lipolytica@XP_504318[RRM1][KOG0147]Ostreococcus@jgi_Ost9901_3_42846[2][RRM1:100%][put-sr:50%][KOG0147:100%]
Volvox carteri@jgi_Volca1_84128[2][RRM1:100%][put-sr:50%][KOG0147:100%]Plasmodium falciparum_3D7@XP_001349956[RRM1][KOG0147]
Cryptosporidium parvum_Iowa_II@XP_628665[RRM1][KOG0147]Leptospira@YP_001385[4][RRM1:100%*][PROK:100%*]
Ustilago maydis_521@XP_761797[RRM1][put-sr][KOG3257]Ostreococcus@jgi_Ost9901_3_27365[2][RRM1:100%][KOG0123:50%]
Desulfuromonadales@NP_952377[4][RRM1:100%*][PROK:100%*][KOG0108:50%][.KOG0145:25%]Pelobacter carbinolicus_DSM_2380@YP_357907[RRM1][PROK][KOG0145]
Magnoliophyta@NP_189032[4][RRM1:100%*][put-sr:100%*][KOG0670:100%*]Ostreococcus tauri@jgi_Ostta4_24260[RRM1]
Trypanosomatidae@XP_827855[2][RRM1:100%]Aureococcus anophagefferens@jgi_Auran1_67810[RRM1][put-sr][KOG0120]
Aureococcus anophagefferens@jgi_Auran1_66158[RRM1][put-sr][KOG0149]Magnoliophyta@10511_m000028_AZM5_5258[15][RRM1:100%**][cpRNP:33%*][KOG0127:53%**][.KOG0131:27%*][.KOG0145:13%][.KOG0108:7%]
Chlamydomonadales@jgi_Volca1_103054[2][RRM3:50%][.RRM2:50%][KOG0055:50%]rosids@30054_m000821[3][RRM1:100%*][cpRNP:33%][KOG0127:100%*]
Oryza sativa_japonica_cultivar-group@NP_001053710[RRM1][KOG0127]Magnoliophyta@NP_001058927[3][RRM1:100%*][cpRNP:33%][KOG0131:67%]Magnoliophyta@NP_001062760[4][RRM1:100%*][KOG0124:50%][.KOG0131:50%]
Embryophyta@jgi_Phypa1_1_134646[11][RRM1:100%**][cpRNP:9%][KOG0123:45%*][.KOG0127:36%*][.KOG2029:9%]rosids@NP_171616[3][RRM2:100%*][cpRNP:67%][KOG0148:67%][.KOG0110:33%]
Oryza sativa_japonica_cultivar-group@NP_001060859[RRM2][KOG0110]Magnoliophyta@29333_m001057[3][RRM2:67%][.RRM1:33%][cpRNP:33%][KOG0131:67%][.KOG0148:33%]
Magnoliophyta@NP_001048500[5][RRM2:100%*][cpRNP:20%][KOG0123:100%*]Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM3][KOG0123]
Magnoliophyta@IMGA_AC119413_25_2[4][RRM2:100%*][cpRNP:25%][KOG0127:100%*]Poaceae@19213_m000022_AZM5_85721[2][RRM1:50%][.RRM2:50%][KOG0127:50%]
Ricinus communis@29908_m006094[RRM2][KOG0110]Arabidopsis thaliana@NP_192643[2][RRM2:100%][KOG0110:100%]
75 - CAPER
UMH
73 - SART3
68 - FOX
60
88 - prokaryotic RRMs
Fig. S7
102
91
60
57 74
59
92
82
68
51
53
69
50
Aureococcus anophagefferens@jgi Auran1 60739[RRM1][put-sr][KOG1860]Trypanosomatidae@XP_847111[2][RRM1:100%]
Leishmania infantum_JPCM5@XP_001465764[RRM1]Trypanosoma brucei_TREU927@XP_846161[RRM2]
Trypanosoma brucei_TREU927@XP_846161[RRM1]Leishmania infantum_JPCM5@XP_001463160[RRM2][put-sr]
Ricinus communis@30146_m003481[RRM3][KOG0123]Phytophthora@jgi_Physo1_1_108322[2][RRM3:100%][KOG0123:100%]
Thalassiosira pseudonana@jgi_Thaps3_13224[RRM3][KOG0123]Phaeodactylum tricornutum@jgi_Phatr2_23959[RRM3][KOG0123]
Cryptosporidium parvum_Iowa_II@XP_001388334[RRM3][KOG0123]Theileria parva_strain_Muguga@XP_766466[RRM3][KOG0123]Plasmodium falciparum_3D7@XP_001350640[RRM3][KOG0123]
Debaryomyces hansenii_CBS767@XP_460681[RRM2][KOG0128]Saccharomyces cerevisiae@YMR268C[RRM2][KOG0128]
Schizosaccharomyces pombe_972h-@NP_596721[RRM2][KOG0128]Pezizomycotina@XP_749317[2][RRM2:100%][KOG0128:100%]
Strongylocentrotus purpuratus@XP_786044[2][RRM1:100%][KOG0117:100%]Embryophyta@jgi_Phypa1_1_140180[4][RRM3:100%*][KOG0117:100%*]
Trypanosoma brucei_TREU927@XP_844190[RRM1][KOG0144]Dictyostelium discoideum_AX4@XP_635793[RRM1][KOG0145]
Dictyostelium discoideum_AX4@XP_635793[RRM2][KOG0145]Dictyostelium discoideum_AX4@XP_644081[RRM1][KOG0123]
Dictyostelium discoideum_AX4@XP_646802[RRM1][KOG0145]Bilateria@ENSORLP00000021434[219][RRM1:100%*****][ELAV:79%*****][KOG0145:100%*****]Diptera@AAEL011150-PA[15][RRM1:100%**][KOG0145:100%**]
Drosophila melanogaster@CG5213-PA[RRM1][KOG0145]Trypanosomatidae@XP_828145[5][RRM1:100%*][KOG0145:100%*]
Trypanosoma brucei_TREU927@XP_845996[RRM1][KOG0122]Trypanosomatidae@XP_843886[2][RRM1:100%][KOG0145:100%]
Dictyostelium discoideum_AX4@XP_629639[RRM1][KOG0145]Dictyostelium discoideum_AX4@XP_644081[RRM3][KOG0123]
Dictyostelium discoideum_AX4@XP_635793[RRM3][KOG0145]Caenorhabditis elegans@F35H8_5[RRM3][KOG0145]
Coelomata@ENSTBEP00000015452[229][RRM3:88%*****][.RRM2:9%**][ELAV:82%*****][KOG0145:100%*****]Ciona@ENSCINP00000023191[4][RRM3:75%*][.RRM1:25%][KOG0145:100%*]
Plasmodium falciparum_3D7@XP_001350320[RRM3][KOG0123]Aconoidasida@XP_001349292[3][RRM2:100%*][KOG0146:67%][.KOG0144:33%]
Cryptosporidium parvum_Iowa_II@XP_626331[RRM1][KOG0146]Bilateria@ENSORLP00000004891[130][RRM1:100%****][RBMS:72%****][KOG0145:99%****]
Eukaryota@ENSOANP00000006980[251][RRM3:67%*****][.RRM2:24%****][.RRM1:10%***][Bruno:50%****][KOG0144:55%****][.KOG0146:45%****]Cryptosporidium parvum_Iowa_II@XP_001388078[RRM3][put-sr][KOG0144]
Theileria parva_strain_Muguga@XP_766017[RRM3][KOG0144]Plasmodium falciparum_3D7@XP_001350320[RRM2][KOG0123]
Yarrowia lipolytica@XP_500351[RRM1][KOG0123]Tetraodon nigroviridis@GSTENP00024897001[RRM1][PABP][KOG0123]
Eukaryota@ENSXETP00000023927[236][RRM1:100%*****][PABP:55%****][KOG0123:100%*****]Trypanosomatidae@XP_001469222[2][RRM1:100%][KOG0123:100%]Leishmania infantum_JPCM5@XP_001466041[RRM1][KOG0123]
Trypanosomatidae@XP_001469326[2][RRM1:100%][KOG0123:100%]Saccharomycetaceae@YFR023W[4][RRM1:100%*][KOG0123:100%*]
Candida glabrata_CBS138@XP_447635[RRM1][KOG0123]Oryza sativa_japonica_cultivar-group@NP_001049727[RRM1][KOG0123]
Danio rerio@ENSDARP00000091192[14][RRM1:100%**][put-sr:100%**][KOG0123:100%**]rosids@30078_m002213[3][RRM1:100%*][PABP:33%][KOG0123:100%*]
Ricinus communis@30146_m003481[RRM1][KOG0123]Arabidopsis thaliana@NP_188259[RRM1][PABP][KOG0123]
Encephalitozoon cuniculi_GB-M1@NP_584552[RRM3][KOG0123]Myotis lucifugus@ENSMLUP00000003020[RRM3][PTBP][KOG1190]Embryophyta@IMGA_AC141435_12_2[17][RRM2:76%**][.RRM1:24%*][KOG4660:100%**]
Tetrapoda@ENSXETP00000004736[17][RRM2:59%**][.RRM1:41%*][PTBP:94%**][KOG1190:100%**]Drosophila melanogaster@CG2050-PA[RRM3]
Theria@ENSMODP00000002817[2][RRM1:100%]Theileria parva_strain_Muguga@XP_764943[RRM1][KOG4206]
Pichia stipitis_CBS_6054@XP_001382592[RRM1][KOG4206]Coelomata@ENSORLP00000008206[18][RRM1:100%**][snRNP:83%**][KOG4206:100%**]
Sordariomycetes@XP_962704[2][RRM1:100%][put-sr:50%][KOG4206:100%]Ciona intestinalis@ENSCINP00000027768[RRM1][KOG0548]
Eutheria@ENSETEP00000000464[10][RRM1:100%**][put-sr:100%**][KOG0132:100%**]Endopterygota@CG4266-PA[5][RRM1:100%*][put-sr:100%*][KOG0132:100%*]
Plasmodium falciparum_3D7@XP_001348072[RRM1][KOG0144]Clupeocephala@ENSORLP00000009616[3][RRM1:100%*][KOG0548:100%*]
Strongylocentrotus purpuratus@XP_001188888[2][RRM1:100%][KOG0548:100%]Dictyostelium discoideum_AX4@XP_645138[RRM1]
Danio rerio@ENSDARP00000075089[2][RRM1:100%][KOG0548:100%]Gasterosteus aculeatus@ENSGACP00000006521[RRM1][KOG0548]
Schizosaccharomyces pombe_972h-@NP_595389[RRM1][KOG4574]Yarrowia lipolytica@XP_500252[RRM1][KOG4574]
Cryptococcus neoformans_var._neoformans_JEC21@XP_570411[RRM2][KOG4574]Neurospora crassa_OR74A@XP_962915[RRM1][KOG4574]
Dictyostelium discoideum_AX4@XP_644288[RRM1][KOG3598]Dictyostelium discoideum_AX4@XP_644288[RRM2][KOG3598]
Schizosaccharomyces pombe_972h-@NP_588373[RRM1]Physcomitrella patens@jgi_Phypa1_1_176266[RRM1][KOG1924]
Oryza sativa_japonica_cultivar-group@NP_001063671[RRM2][KOG0123]rosids@NP_001078046[5][RRM2:100%*][FCAFPA:80%*][KOG0117:80%*][.KOG0123:20%]
Physcomitrella patens@jgi_Phypa1_1_161310[RRM2][KOG3598]Dictyostelium discoideum_AX4@XP_629218[RRM2][KOG0151]
Dictyostelium discoideum_AX4@XP_629218[RRM1][KOG0151]Aedes aegypti@AAEL010888-PA[RRM2]
Saccharomyces cerevisiae@YMR302C[RRM1]Physcomitrella patens@jgi_Phypa1_1_161310[RRM3][KOG3598]Volvox carteri@jgi_Volca1_88720[RRM3]
Chlamydomonas reinhardtii@jgi_Chlre3_148816[RRM2][KOG3598]Physcomitrella patens@jgi_Phypa1_1_137240[2][RRM1:100%][KOG3598:50%]
Arabidopsis thaliana@NP_181869[4][RRM1:100%*][FCAFPA:100%*][KOG0117:100%*]Ricinus communis@29577_m000447[RRM1][KOG0123]
Ricinus communis@30005_m001243[RRM1]Oryza sativa_japonica_cultivar-group@NP_001062811[RRM1][KOG1190]
40 - snRNP
43
3 - PABP
9 - Bruno
12 - ELAV
10 - ELAV
Fig. S8
103
98
56 76
81
77
97
51
61 58
85
73
60 59
64
80
51
83
Chlamydomonadales@jgi Volca1 118581[3][RRM2:67%][.RRM4:33%][KOG0144:67%][.KOG1240:33%]Volvox carteri@jgi_Volca1_88093[RRM4][KOG1240]
Embryophyta@30076_m004622[9][RRM1:100%**][FCAFPA:22%][KOG0144:100%**]Arabidopsis thaliana@NP_850472[RRM1][FCAFPA][KOG0144]
Medicago truncatula@IMGA_AC155099_2_2[2][RRM1:100%][KOG0144:100%]Saccharomycetaceae@XP_451236[2][RRM1:100%][KOG0144:100%]
Saccharomyces cerevisiae@YGR250C[RRM1][KOG0108]Eutheria@ENSBTAP00000025092[6][RRM1:100%*][KOG0117:100%*]
Gasterosteus aculeatus@ENSGACP00000025947[RRM1][KOG0117]Aedes aegypti@AAEL015050-PA[2][RRM1:100%][KOG0117:100%]
Anopheles gambiae@AGAP002326-PA[RRM1]Tribolium castaneum@XP_967803[2][RRM1:100%][KOG0117:100%]
Rattus norvegicus@ENSRNOP00000053644[RRM1][KOG0117]Eutheria@ENSCPOP00000011171[3][RRM1:100%*][hnRNP:67%][KOG0117:100%*]Bilateria@ENSGALP00000025475[210][RRM1:100%*****][hnRNP:33%****][KOG0117:100%*****]
Dictyostelium discoideum_AX4@XP_646268[RRM2][KOG0146]Chlamydomonadales@jgi_Volca1_88093[2][RRM1:100%][KOG1240:100%]
Theileria parva_strain_Muguga@XP_766017[RRM1][KOG0144]Cryptosporidium parvum_Iowa_II@XP_001388078[RRM1][put-sr][KOG0144]
Plasmodium falciparum_3D7@XP_001350299[RRM1][KOG0144]Cryptosporidium parvum_Iowa_II@XP_628265[RRM1][KOG0144]
Phytophthora@jgi_Phyra1_1_82644[2][RRM1:100%][KOG0144:100%]Coelomata@XP_782270[24][RRM1:100%***][Bruno:42%**][KOG0144:100%***]
Bilateria@ENSXETP00000031370[81][RRM1:100%****][Bruno:42%***][KOG0146:84%****][.KOG0144:16%**]Thalassiosira pseudonana@jgi_Thaps3_261541[RRM1][KOG0144]
Phaeodactylum tricornutum@jgi_Phatr2_42828[RRM1][KOG0144]Plasmodium falciparum_3D7@XP_001348607[RRM1]
Chlamydomonadales@jgi_Volca1_107765[2][RRM1:100%][KOG0145:100%]Saccharomycetales@NP_984279[4][RRM1:100%*][KOG0921:75%*][.KOG0106:25%]
Drosophila melanogaster@CG3312-PA[2][RRM1:100%][KOG0128:100%]Drosophila melanogaster@CG5213-PA[RRM2][KOG0145]
Dictyostelium discoideum_AX4@XP_645848[RRM1][put-sr]Dictyostelium discoideum_AX4@XP_647083[RRM1]
Cryptococcus neoformans_var._neoformans_JEC21@XP_567374[RRM1][KOG0307]Embryophyta@30128_m008555[15][RRM1:100%**][KOG4660:100%**]
Chlamydomonas reinhardtii@jgi_Chlre3_152680[RRM1][KOG4660]Embryophyta@28611_m000102[4][RRM2:100%*][put-sr:75%*][KOG0154:100%*]
Chlamydomonas reinhardtii@jgi_Chlre3_145376[RRM2]Phytophthora ramorum@jgi_Phyra1_1_77702[RRM1][KOG0154]
Volvox carteri@jgi_Volca1_120369[RRM1][put-sr][KOG0147]Schizosaccharomyces pombe_972h-@NP_596424[RRM2][KOG4206]
Pezizomycotina@XP_753458[2][RRM2:100%][put-sr:50%][KOG4206:100%]Saccharomyces cerevisiae@YBR119W[RRM1]
Plasmodium falciparum_3D7@XP_001349796[RRM2][KOG4206]Theileria parva_strain_Muguga@XP_764943[RRM2][KOG4206]
Eukaryota@ENSGACP00000013006[79][RRM2:96%****][snRNP:30%***][KOG4206:100%****]Cryptococcus neoformans_var._neoformans_JEC21@XP_568533[RRM2][KOG4206]
Cyanidioschyzon merolae@gnl_CMER_CMS187C[RRM1][KOG0123]Dictyostelium discoideum_AX4@XP_644081[RRM2][KOG0123]
Trypanosomatidae@XP_001468777[2][RRM2:100%][KOG0144:100%]Culicidae@AAEL001131-PA[2][RRM1:100%][KOG0113:100%]
Euteleostomi@ENSXETP00000044031[49][RRM2:76%***][.RRM1:24%**][KOG0145:41%**][.KOG0123:14%*][.KOG0110:14%*]Ciona@ENSCSAVP00000018820[2][RRM2:100%][KOG0145:100%]
Aureococcus anophagefferens@jgi_Auran1_31715[RRM1][KOG0149]Volvox carteri@jgi_Volca1_84128[RRM2][KOG0147]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM4][KOG0123]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM5][KOG0123]
Embryophyta@jgi_Phypa1_1_189930[7][RRM1:100%*][KOG0119:86%*][.KOG0307:14%]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM6][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM1][KOG0123]Oryza sativa_japonica_cultivar-group@NP_001054296[RRM2][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001054296[RRM3][KOG0123]Phytophthora ramorum@jgi_Phyra1_1_94226[RRM1][put-sr][KOG0941]
Eukaryota@NP_001063859[35][RRM1:100%***][ZCRB1:69%***][KOG0108:40%**][.KOG0122:9%*][.KOG0117:6%][.KOG0107:6%]Aedes aegypti@AAEL006197-PA[RRM1][KOG0108]
Chlamydomonas reinhardtii@jgi_Chlre3_120019[RRM2][KOG0106]Chlamydomonas reinhardtii@jgi_Chlre3_80366[RRM2][KOG0106]
Embryophyta@29742_m001371[15][RRM2:80%**][.RRM1:20%*][put-sr:87%**][SR:67%**][KOG0106:100%**]Bacillariophyta@jgi_Phatr2_47737[2][RRM1:100%][put-sr:50%]
Cyanidioschyzon merolae@gnl_CMER_CMO009C[RRM2]Thalassiosira pseudonana@jgi_Thaps3_2206[RRM1]
Phaeodactylum tricornutum@jgi_Phatr2_38474[RRM1]Ricinus communis@30169_m006629[RRM1][KOG0123]
Cyanidioschyzon merolae@gnl_CMER_CMG025C[RRM1][KOG1080]Ustilago maydis_521@XP_760296[RRM1]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572996[RRM1]Euteleostomi@ENSOANP00000013028[22][RRM1:100%***]
Endopterygota@XP_967886[3][RRM1:100%*]Drosophila melanogaster@CG14414-PB[RRM1]
Phaeodactylum tricornutum@jgi_Phatr2_10122[RRM1][KOG0153]Leishmania infantum_JPCM5@XP_001466666[RRM1][KOG0145]Leishmania infantum_JPCM5@XP_001464835[2][RRM1:100%][KOG0145:100%]
Leishmania infantum_JPCM5@XP_001464836[RRM1][KOG0145]Trypanosoma brucei_TREU927@XP_843985[3][RRM1:100%*][put-sr:33%][KOG0110:100%*]
Leishmania infantum_JPCM5@XP_001466665[RRM1][KOG0110]Leishmania infantum_JPCM5@XP_001466659[RRM1][KOG0145]
Trypanosomatidae@XP_847495[2][RRM1:100%][KOG0110:50%][.KOG0127:50%]Nasonia vitripennis@XP_001604889[RRM2][KOG0144]
Dictyostelium discoideum_AX4@XP_636266[RRM1][KOG3598]Strongylocentrotus purpuratus@XP_001199679[4][RRM1:100%*][KOG0145:50%]
Euteleostomi@ENSDNOP00000001522[23][RRM1:100%***][RBM:61%**][KOG0144:87%**][.KOG0145:13%*]Endopterygota@CG1316-PA[5][RRM1:100%*][KOG0144:80%*][.KOG0148:20%]
Encephalitozoon cuniculi_GB-M1@NP_584552[RRM1][KOG0123]Dictyostelium discoideum_AX4@XP_641568[RRM3][KOG3598]
Schizosaccharomyces pombe_972h-@NP_595190[RRM1][KOG0111]Chlamydomonas reinhardtii@jgi_Chlre3_194261[RRM1][KOG0123]
Embryophyta@NP_001063403[14][RRM1:100%**][KOG0148:100%**]Clupeocephala@ENSORLP00000016619[5][RRM1:100%*][KOG0131:60%*][.KOG0123:40%]Endopterygota@XP_974444[2][RRM1:100%][KOG0144:100%]
Cryptosporidium parvum_Iowa_II@XP_627780[RRM2][KOG0131]Saccharomyces cerevisiae@YOR319W[RRM2][KOG0131]
Eukaryota@jgi_Physo1_1_108557[316][RRM2:91%*****][.RRM1:9%***][PABP:46%****][KOG0123:79%*****][.KOG0131:21%****]Yarrowia lipolytica@XP_503979[RRM2][KOG0131]
Saccharomycetaceae@XP_001385635[2][RRM2:100%][KOG0131:100%]Plasmodium falciparum_3D7@XP_001348201[RRM1][KOG0151]
Eukaryota@jgi_Volca1_104604[49][RRM1:100%***][put-sr:78%***][KOG0151:100%***]Cryptococcus neoformans_var._neoformans_JEC21@XP_571608[RRM1][put-sr][KOG0151]
Saccharomycetales@XP_454345[4][RRM1:100%*][KOG0148:75%*][.KOG0123:25%]Sordariomycetes@XP_385593[2][RRM1:100%][KOG0148:100%]
Saccharomycetaceae@XP_001383142[2][RRM1:100%][put-sr:100%][KOG0148:100%]Yarrowia lipolytica@XP_501542[RRM1][KOG0131]
Cryptococcus neoformans_var._neoformans_JEC21@XP_570577[RRM1][KOG0148]Ustilago maydis_521@XP_757329[RRM1][KOG0145]
Embryophyta@NP_188026[13][RRM1:100%**][oligoU:38%*][KOG0148:100%**]Bilateria@ENSSARP00000011721[82][RRM1:100%****][TIATIAR:80%****][KOG0148:100%****]
Trypanosoma brucei_TREU927@XP_829272[RRM1][KOG0145]Leishmania infantum_JPCM5@XP_001463465[RRM1][KOG0122]
Trypanosomatidae@XP_829274[2][RRM1:100%][KOG0145:50%]Leishmania infantum_JPCM5@XP_001463468[RRM1]
Aureococcus anophagefferens@jgi_Auran1_60739[RRM1][put sr][KOG1860]
76 - TIA TIAR
OligoU
13
4 - PABP
PSP1
PSF
p54rnb missing
green plant-specific
RS group of SR proteins
- 56
57 - ZCRB1
41 - snRNP
42
2 - hnRNP
7 - Bruno
FCA FPA
Fungal SR (ScNp13) ?
Fig. S8
104
64
61 50
65
89
80
75
68
52
81
73
98
Oryza sativa japonica cultivar-group@NP 001067112[RRM2][put-sr][KOG0117]Saccharomycetales@XP_454821[4][RRM1:100%*][KOG3598:50%][.KOG1984:25%]
Coelomata@XP_974651[54][RRM2:83%***][.RRM1:17%**][put-sr:87%***][RBM:37%**][KOG0112:100%***]Strongylocentrotus purpuratus@XP_001184502[2][RRM2:100%][put-sr:100%][KOG1144:100%]
Coelomata@ENSMMUP00000010529[37][RRM3:54%**][.RRM2:41%**][.RRM1:5%][put-sr:92%***][KOG0112:84%***][.KOG3598:8%*]Ciona intestinalis@ENSCINP00000004384[RRM2][KOG0148]
Dictyostelium discoideum_AX4@XP_641688[RRM1][KOG0117]Strongylocentrotus purpuratus@XP_001183631[2][RRM2:100%][KOG0148:100%]
Physcomitrella patens@jgi_Phypa1_1_170658[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_13402[RRM1][KOG0226]
Thalassiosira pseudonana@jgi_Thaps3_18991[RRM1][KOG0226]Cryptococcus neoformans_var._neoformans_JEC21@XP_571861[RRM1][KOG0226]
Nasonia vitripennis@XP_001603091[RRM1][KOG0226]Eukaryota@XP_964958[72][RRM1:100%****][KOG0226:100%****]
Yarrowia lipolytica@XP_501542[RRM2][KOG0131]Eukaryota@IMGA_AC144483_30_2[123][RRM2:83%****][.RRM1:17%***][TIATIAR:58%****][.oligoU:6%*][KOG0148:99%****]
Ustilago maydis_521@XP_757329[RRM2][KOG0145]Dictyostelium discoideum_AX4@XP_635179[RRM1][KOG0148]
Saccharomycetales@XP_460477[6][RRM1:67%*][.RRM2:33%][KOG0148:67%*][.KOG3598:17%][.KOG0145:17%]Eukaryota@ENSMUSP00000030730[72][RRM2:85%****][.RRM1:15%**][oligoU:10%*][KOG0148:58%***][.KOG0123:25%**][.KOG0131:14%**]
Saccharomycetales@XP_455748[4][RRM2:100%*][KOG0148:75%*][.KOG0145:25%]Pichia stipitis_CBS_6054@XP_001386002[RRM2][KOG0148]
Debaryomyces hansenii_CBS767@XP_461354[RRM2][KOG0148]Aureococcus anophagefferens@jgi_Auran1_28594[RRM2][KOG0148]Endopterygota@AAEL011988-PA[5][RRM2:100%*][KOG0144:80%*][.KOG0145:20%]
Ciona@ENSCSAVP00000020066[4][RRM1:50%][.RRM2:50%][KOG0131:50%]Strongylocentrotus purpuratus@XP_793862[2][RRM2:100%][KOG0144:100%]
Volvox carteri@jgi_Volca1_116517[RRM2][KOG1984]Dictyostelium discoideum_AX4@XP_646802[RRM2][KOG0145]
Coelomata@ENSTBEP00000005385[105][RRM2:86%****][.RRM1:14%**][P54nrb:30%***][.PSP1:24%***][.PSF:21%***][KOG0115:100%****]Trypanosomatidae@XP_001469326[2][RRM4:100%][KOG0123:100%]
Trypanosomatidae@XP_001469222[2][RRM4:100%][KOG0123:100%]Dictyostelium discoideum_AX4@XP_629639[RRM2][KOG0145]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569319[RRM1][KOG0123]Ustilago maydis_521@XP_759458[RRM2][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001049727[RRM3][KOG0123]Dictyostelium discoideum_AX4@XP_001134510[RRM4][KOG0123]
rosids@30078_m002213[3][RRM3:100%*][PABP:33%][KOG0123:100%*]Arabidopsis thaliana@NP_195978[RRM1][KOG0123]
Schizosaccharomyces pombe_972h-@NP_593427[RRM2][KOG0123]Schizosaccharomyces pombe_972h-@NP_001018242[RRM3][KOG0123]
Ashbya gossypii_ATCC_10895@NP_984845[RRM2][KOG0123]Leishmania infantum_JPCM5@XP_001466041[RRM2][KOG0123]
Encephalitozoon cuniculi_GB-M1@NP_586226[RRM2][put-sr][KOG0123]Arabidopsis thaliana@NP_174676[RRM1][PABP][KOG0123]
Oryza sativa_japonica_cultivar-group@NP_001049727[RRM2][KOG0123]rosids@30078_m002213[3][RRM2:100%*][PABP:33%][KOG0123:100%*]
rosids@30146_m003481[2][RRM2:100%][PABP:50%][KOG0123:100%]Yarrowia lipolytica@XP_500351[RRM3][KOG0123]
Aedes aegypti@AAEL007013-PA[RRM1][KOG0123]Pezizomycotina@XP_750167[2][RRM4:100%][KOG0123:100%]
Eukaryota@ENSDNOP00000002400[249][RRM4:82%*****][.RRM3:11%***][.RRM2:6%**][PABP:54%****][KOG0123:100%*****]Arabidopsis thaliana@NP_188259[RRM4][PABP][KOG0123]
Leishmania infantum_JPCM5@XP_001466041[RRM4][KOG0123]Drosophila melanogaster@CG4612-PA[RRM2][KOG0123]
Dictyostelium discoideum_AX4@XP_629007[RRM3][KOG0123]Anopheles gambiae@AGAP000921-PA[3][RRM1:100%*]
Eukaryota@ENSETEP00000015606[204][RRM3:85%*****][.RRM2:11%***][PABP:66%****][KOG0123:100%*****]Trypanosoma brucei_TREU927@XP_827358[RRM3][KOG0123]
Leishmania infantum_JPCM5@XP_001469222[RRM3][KOG0123]Felis catus@ENSFCAP00000004622[RRM3][PABP][KOG0123]
Encephalitozoon cuniculi_GB-M1@NP_586099[RRM2][KOG0131]Caenorhabditis elegans@Y106G6H_2a_4[7][RRM3:71%*][.RRM2:29%][KOG0123:100%*]
Caenorhabditis elegans@F18H3_3b[5][RRM3:100%*][KOG0123:100%*]Trypanosoma brucei_TREU927@XP_827237[RRM3][KOG0123]
Dikarya@XP_960425[12][RRM3:100%**][PABP:17%][KOG0123:100%**]Yarrowia lipolytica@XP_501289[RRM3][KOG0123]
Echinops telfairi@ENSETEP00000008100[RRM3][PABP][KOG0123]Chlamydomonadales@jgi_Volca1_82578[2][RRM3:100%][PABP:100%][KOG0123:100%]
Strongylocentrotus purpuratus@XP_001177782[4][RRM3:50%][.RRM2:50%][KOG0123:100%*]Neurospora crassa_OR74A@XP_958552[RRM3][KOG0128]
Trypanosoma brucei_TREU927@XP_845376[RRM3][KOG0148]Diptera@AGAP003899-PA[15][RRM2:100%**][KOG0145:100%**]Bilateria@CG3151-PE[218][RRM2:92%*****][.RRM1:7%**][ELAV:84%*****][KOG0145:100%*****]
Ciona@ENSCSAVP00000015853[4][RRM2:100%*][KOG0145:100%*]Coelomata@ENSORLP00000004891[62][RRM2:94%****][.RRM1:6%*][RBMS:79%***][KOG0145:100%****]
Ustilago maydis_521@XP_759141[RRM2][KOG0145]Embryophyta@29727_m000492[13][RRM3:92%**][.RRM2:8%][oligoU:46%*][KOG0148:100%**]Dikarya@XP_570577[4][RRM3:100%*][KOG0148:100%*]
Saccharomycetales@YNL016W[6][RRM3:100%*][put-sr:33%][KOG0148:83%*][.KOG0123:17%]Coelomata@CG4787-PA[102][RRM3:74%****][.RRM2:16%**][.RRM1:11%**][TIATIAR:75%****][KOG0148:100%****]
Caenorhabditis elegans@Y46G5A_13[10][RRM2:80%**][.RRM3:20%][KOG0148:100%**]Caenorhabditis elegans@C07A4_1[RRM2][KOG0148]
Embryophyta@NP_001067623[8][RRM1:100%**][KOG0117:100%**]Oryza sativa_japonica_cultivar-group@NP_001066102[RRM1][KOG0117]
rosids@NP_001030849[6][RRM1:100%*][KOG0117:100%*]Ornithorhynchus anatinus@ENSOANP00000022523[3][RRM1:67%][.RRM2:33%][KOG2248:100%*]
Physcomitrella patens@jgi_Phypa1_1_140180[3][RRM1:100%*][KOG0117:100%*]Magnoliophyta@29709_m001182[6][RRM1:100%*][put-sr:17%][KOG0117:100%*]
Ricinus communis@30072_m000974[RRM1][KOG0117]Oryza sativa_japonica_cultivar-group@NP_001064224[RRM1][KOG0117]
Dictyostelium discoideum_AX4@XP_641568[RRM2][KOG3598]Caenorhabditis elegans@F25B5_7d[2][RRM1:100%][KOG0115:100%]Deuterostomia@ENSDNOP00000008593[94][RRM1:100%****][P54nrb:28%***][.PSP1:21%**][.PSF:18%**][KOG0115:99%****]
Endopterygota@CG10328-PA[9][RRM1:100%**][P54nrb:33%*][KOG0115:100%**]Thalassiosira pseudonana@jgi_Thaps3_261541[RRM2][KOG0144]
Aconoidasida@XP_766017[2][RRM2:100%][KOG0144:100%]Cryptosporidium parvum_Iowa_II@XP_001388078[RRM2][put-sr][KOG0144]
Plasmodium falciparum_3D7@XP_001348269[RRM2][KOG0144]Arabidopsis thaliana@NP_850472[RRM2][FCAFPA][KOG0144]
Embryophyta@29889_m003323[11][RRM2:100%**][FCAFPA:18%][KOG0144:100%**]Dictyostelium discoideum_AX4@XP_635247[RRM2][KOG0144]Bilateria@AGAP009477-PA[250][RRM2:73%*****][.RRM1:27%****][Bruno:59%****][KOG0144:56%****][.KOG0146:44%****]
Embryophyta@jgi_Phypa1_1_115029[9][RRM2:100%**][KOG0144:100%**]Phytophthora@jgi_Physo1_1_133760[2][RRM2:100%][KOG0144:100%]
Theileria parva_strain_Muguga@XP_766722[RRM1][KOG0144]Plasmodium falciparum_3D7@XP_001349292[RRM1][KOG0146]
Chlamydomonadales@jgi_Chlre3_99329[2][RRM1:50%][.RRM2:50%][KOG0144:100%]Volvox carteri@jgi_Volca1_72841[RRM1][KOG0144]
Dictyostelium discoideum_AX4@XP_646268[RRM1][KOG0146]Dictyostelium discoideum_AX4@XP_635247[RRM1][KOG0144]
Poaceae@11320_m000014_AZM5_6848[3][RRM1:100%*][KOG0144:100%*]Physcomitrella patens@jgi_Phypa1_1_107590[2][RRM1:100%][KOG0144:100%]Trypanosomatidae@XP_845656[2][RRM1:100%][KOG0131:50%]
Trypanosomatidae@XP_001468238[3][RRM1:100%*][KOG0144:100%*]Leishmania infantum_JPCM5@XP_001468236[RRM1]
Chlamydomonadales@jgi_Volca1_72841[2][RRM3:50%][.RRM2:50%][KOG0144:100%]Trypanosomatidae@XP_827838[2][RRM1:100%][KOG0144:100%]
Cryptosporidium parvum_Iowa_II@XP_628265[RRM2][KOG0144]Chlamydomonadales@jgi_Volca1_118581[3][RRM2:67%][.RRM4:33%][KOG0144:67%][.KOG1240:33%]
8 - Bruno
FCA FPA
Part of 33 - p54nrb
62
79 - TIA TIAR
OligoU11 - ELAV
RBMS
5 - PABP
6 - PABP
66 - PaBP
Part of 4 -
p54rnb
77 - TIA TIAR
OligoU
53 - RBM
5455
Fig. S8
105
60
71 71
82
79
50
80 58
70
69
55 50
53
71
93
Deuterostomia@ENSMODP00000011218[78][RRM1:100%****][G3BP:82%****][KOG0116:100%****]Tribolium castaneum@XP_975463[RRM1][KOG0116]
Apis mellifera@XP_623996[RRM1][KOG0116]Neurospora crassa_OR74A@XP_958552[RRM1][KOG0128]
Leishmania infantum_JPCM5@XP_001466413[RRM3][put-sr][KOG0147]Xenopus tropicalis@ENSXETP00000012439[RRM1][KOG2277]
Strongylocentrotus purpuratus@XP_798256[2][RRM1:100%][KOG2277:100%]Oryzias latipes@ENSORLP00000005442[2][RRM1:100%][KOG2277:100%]
Oryctolagus cuniculus@ENSOCUP00000014792[RRM1][KOG2277]Strongylocentrotus purpuratus@XP_001178467[2][RRM1:100%][put-sr:100%]Endopterygota@CG5655-PA[5][RRM1:100%*][put-sr:100%*][KOG0107:80%*][.KOG0921:20%]
Strongylocentrotus purpuratus@XP_001180596[2][RRM1:100%][put-sr:100%]Eukaryota@ENSGALP00000022397[157][RRM1:100%*****][put-sr:75%****][SR:59%****][KOG0107:66%****]
Theileria parva_strain_Muguga@XP_766728[RRM1][KOG0124]Dictyostelium discoideum_AX4@XP_001134500[RRM1][put-sr][KOG0147]
Strongylocentrotus purpuratus@XP_001185906[2][RRM1:100%][KOG0107:100%]Dictyostelium discoideum_AX4@XP_638672[RRM1][put-sr][KOG0147]
Phytophthora@jgi_Physo1_1_140403[2][RRM1:100%][put-sr:100%][KOG0127:100%]Dictyostelium discoideum_AX4@XP_628876[RRM1]
Yarrowia lipolytica@XP_500797[RRM1][put-sr]Schizosaccharomyces pombe_972h-@NP_596398[RRM1][put-sr][SR]
Ustilago maydis_521@XP_758616[RRM1]Plasmodium falciparum_3D7@XP_001351730[RRM1][put-sr][KOG0105]
Ostreococcus lucimarinus@jgi_Ost9901_3_8794[RRM1][KOG0105]Embryophyta@NP_194280[13][RRM1:100%**][put-sr:77%**][SR:62%**][KOG0106:100%**]
Ascomycota@YDL224C[8][RRM1:88%*][.RRM2:12%][KOG3598:12%][.KOG1457:12%]Ricinus communis@28452_m000049[RRM1][KOG1457]
Medicago truncatula@IMGA_CU012061_4_1[RRM1]Phytophthora@jgi_Physo1_1_138982[2][RRM1:100%][KOG0105:100%]
Eukaryota@ENSTBEP00000007356[92][RRM1:100%****][put-sr:82%****][SR:65%****][KOG0105:100%****]Theileria parva_strain_Muguga@XP_766386[RRM1][put-sr][KOG0105]
Plasmodium falciparum_3D7@XP_001347876[RRM1][KOG0105]Aedes aegypti@AAEL012621-PA[RRM1][put-sr][KOG0105]
Caenorhabditis elegans@T28D9_2a[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*]Cavia porcellus@ENSCPOP00000010577[RRM1][put-sr][SR][KOG0106]
Ciona intestinalis@ENSCINP00000016525[RRM1][put-sr][KOG0106]Eukaryota@ENSOANP00000021053[127][RRM1:100%****][put-sr:91%****][SR:61%****][KOG0106:55%****][.KOG0105:37%***]
Cryptococcus neoformans_var._neoformans_JEC21@XP_567562[RRM1][KOG0106]Schizosaccharomyces pombe_972h-@NP_594570[RRM1][put-sr][KOG0106]
Neurospora crassa_OR74A@XP_960334[RRM1][put-sr][KOG0105]Coxiella_burnetii@YP_001424503[2][RRM1:100%][PROK:100%][KOG0113:100%]
Aedes aegypti@AAEL010887-PA[RRM6][put-sr][KOG1984]Trypanosomatidae@XP_843959[2][RRM3:100%]
Aspergillus fumigatus_Af293@XP_747328[RRM1][KOG0110]Coxiella_burnetii@YP_001424629[2][RRM1:100%][PROK:100%][KOG0108:100%]
Embryophyta@29900_m001607[13][RRM2:100%**][oligoU:38%*][KOG4205:77%**][.KOG0149:23%*]Embryophyta@jgi_Phypa1_1_44443[2][RRM2:100%][KOG0149:100%]
Legionella_pneumophila@YP_001249669[3][RRM1:100%*][PROK:100%*][put-sr:100%*][KOG0149:100%*]Ostreococcus lucimarinus@jgi_Ost9901_3_7602[RRM1][KOG0145]
Dictyostelium discoideum_AX4@XP_643007[RRM1]eurosids_I@IMGA_CT963106_6_1[2][RRM1:100%][KOG0117:50%]
Arabidopsis thaliana@NP_567594[RRM1][KOG0117]Plasmodium falciparum_3D7@XP_966276[RRM2]
Bilateria@ENSLAFP00000012959[197][RRM3:93%*****][.RRM2:5%**][hnRNP:36%****][KOG0117:100%*****]Strongylocentrotus purpuratus@XP_793277[2][RRM3:100%][KOG0117:100%]
Thalassiosira pseudonana@jgi_Thaps3_263845[RRM1][KOG0108]Phaeodactylum tricornutum@jgi_Phatr2_33658[RRM1]
Dictyostelium discoideum_AX4@XP_638262[RRM1][put-sr][KOG0670]Bilateria@Y47G6A_20a[64][RRM1:100%****][UMH:73%***][KOG0124:100%****]
Phytophthora ramorum@jgi_Phyra1_1_81440[2][RRM1:100%][KOG0124:100%]Cryptosporidium parvum_Iowa_II@XP_628096[RRM1][put-sr][KOG0124]
Dictyostelium discoideum_AX4@XP_638262[RRM2][put-sr][KOG0670]Bilateria@ENSCSAVP00000007991[62][RRM2:95%****][.RRM1:5%*][UMH:74%***][KOG0124:100%****]
Phytophthora@jgi_Phyra1_1_84640[3][RRM2:67%][.RRM1:33%][KOG0124:67%][.KOG0120:33%]Cryptosporidium parvum_Iowa_II@XP_628096[RRM2][put-sr][KOG0124]
Plasmodium falciparum_3D7@XP_001349956[RRM2][KOG0147]Phytophthora@jgi_Phyra1_1_94266[2][RRM2:100%][KOG0147:100%]
Dictyostelium discoideum_AX4@XP_638966[RRM2][KOG0147]Eukaryota@ENSFCAP00000006163[84][RRM2:88%****][.RRM1:12%**][put-sr:86%****][UMH:39%***][.CAPER:8%*][KOG0147:100%****]
Bacillariophyta@jgi_Phatr2_20857[2][RRM2:100%][put-sr:100%][KOG0147:100%]Caenorhabditis elegans@Y55F3AM_3c_1[3][RRM2:100%*][put-sr:33%][UMH:100%*][KOG0147:100%*]
Plasmodium falciparum_3D7@XP_001352080[RRM2]Ascomycota@XP_385341[4][RRM2:100%*][put-sr:100%*][KOG0147:100%*]
Cryptococcus neoformans_var._neoformans_JEC21@XP_571060[RRM2][KOG0147]Ustilago maydis_521@XP_756311[RRM2][put-sr][KOG0147]
Yarrowia lipolytica@XP_504318[RRM2][KOG0147]Dictyostelium discoideum_AX4@XP_636266[RRM3][KOG3598]
Volvox carteri@jgi_Volca1_106063[RRM2]Trypanosoma brucei_TREU927@XP_845742[RRM1][KOG0126]
Saccharomycetaceae@XP_459205[2][RRM1:100%][KOG0126:100%]Eukaryota@AAEL002461-PA[78][RRM1:100%****][put-sr:29%***][KOG0126:100%****]Ustilago maydis_521@XP_760864[RRM1][KOG0126]
Theileria parva_strain_Muguga@XP_766553[RRM1][KOG4208]Cyanidioschyzon merolae@gnl_CMER_CMI122C[RRM1][KOG4208]
Dictyostelium discoideum_AX4@XP_643547[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_45356[RRM1][KOG4208]
Thalassiosira pseudonana@jgi_Thaps3_18198[RRM1][KOG4208]Caenorhabditis elegans@T04A8_6[RRM1][KOG4208]
Eukaryota@CG6937-PA[73][RRM1:100%****][put-sr:5%*][KOG4208:99%****]Anopheles gambiae@AGAP006090-PA[RRM1]
Dictyostelium discoideum_AX4@XP_640243[RRM1][KOG0117]Encephalitozoon cuniculi_GB-M1@NP_585962[RRM2][KOG0123]
Thalassiosira pseudonana@jgi_Thaps3_20887[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_44468[RRM1]
Caenorhabditis elegans@T11G6_8_1[2][RRM1:100%][KOG0153:100%]Coelomata@XP_975014[28][RRM1:100%***][RBM:86%***][KOG0153:100%***]
Ciona@ENSCSAVP00000015574[2][RRM1:100%][KOG0153:100%]Embryophyta@jgi_Phypa1_1_185655[7][RRM1:100%*][KOG0153:100%*]
Ostreococcus@jgi_Ost9901_3_41266[2][RRM1:100%][KOG0153:100%]Dictyostelium discoideum_AX4@XP_635179[RRM2][KOG0148]
Ostreococcus tauri@jgi_Ostta4_31833[RRM2][KOG0148]Schizosaccharomyces pombe_972h-@NP_594243[RRM3][KOG0148]
Eukaryota@YHR086W[51][RRM3:76%***][.RRM2:20%**][oligoU:10%*][KOG0148:90%***]Aureococcus anophagefferens@jgi_Auran1_28594[RRM3][KOG0148]
Phytophthora@jgi_Phyra1_1_50314[2][RRM3:100%][KOG0148:100%]Pichia stipitis_CBS_6054@XP_001384462[RRM2]
Debaryomyces hansenii_CBS767@XP_460517[RRM2][KOG0117]Saccharomycetales@XP_445844[3][RRM2:100%*][KOG0123:33%]
Kluyveromyces lactis@XP_455897[RRM2][KOG0123]Tribolium castaneum@XP_969873[RRM1]
Strongylocentrotus purpuratus@XP_001185821[2][RRM1:100%][KOG0670:100%]Apocrita@XP_623710[2][RRM1:100%]
Euteleostomi@ENSOANP00000024755[113][RRM1:100%****][hnRNP:36%***][.RALYL:15%**]Aedes aegypti@AAEL010890-PA[RRM1][put-sr][KOG0132]
Volvox carteri@jgi_Volca1_107013[RRM3][KOG0117]Saccharomyces cerevisiae@YLL046C[RRM1]
Plasmodium falciparum_3D7@XP_001347332[RRM1][put-sr][KOG0105]Apis mellifera@XP_394565[RRM1][KOG0147]
Zea mays@11279_m000026_AZM5_6772[RRM1][put-sr][KOG0117]Oryza sativa_japonica_cultivar group@NP_001067112[RRM2][put sr][KOG0117]
86 - hnRNP/RALYL
78 - OligoU
14 - RBM
82
69
67 - UMH
Part of 63 - hnRNP
31
16 - dual RRM
SR proteins
17 - single-RRM Zn-K
SR proteins
18
34
Part of 35 - Rasputin
Fungal SR (SpSrp1)
Fungal SR (SpSrp2)
Fig. S8
106
84
71 91
76
97
51
56
70
85 75
53
64
66
91
61
62
Coelomata@XP 001182806[39][RRM1:100%***][KOG0108:13%*][.KOG0116:8%*][.KOG0921:5%]Euteleostomi@ENSSARP00000000775[28][RRM1:100%***][eIF4B:54%**]Ciona@ENSCSAVP00000001842[2][RRM1:100%]
Anopheles gambiae@AGAP000525-PA[RRM1]Drosophila melanogaster@CG10837-PA[3][RRM1:100%*]
Ostreococcus@jgi_Ostta4_33150[2][RRM2:100%][KOG0108:50%]Embryophyta@28180_m000395[6][RRM2:100%*][KOG0124:50%*][.KOG4205:33%][.KOG4211:17%]
Phytophthora@jgi_Physo1_1_141766[2][RRM2:100%][KOG0148:100%]Ostreococcus tauri@jgi_Ostta4_32569[RRM2]
Aureococcus anophagefferens@jgi_Auran1_64341[RRM2][KOG0108]Phaeodactylum tricornutum@jgi_Phatr2_44442[RRM2][KOG4211]
Physcomitrella patens@jgi_Phypa1_1_204078[RRM1][KOG0116]Magnoliophyta@NP_001052571[5][RRM1:100%*][KOG0116:100%*]
Arabidopsis thaliana@NP_189151[RRM1][NTF][KOG0116]Physcomitrella patens@jgi_Phypa1_1_96043[RRM1]
Caenorhabditis elegans@B0035_12_2[2][RRM2:100%][KOG0128:100%]Physcomitrella patens@jgi_Phypa1_1_201182[RRM3][KOG0127]
Magnoliophyta@30131_m007093[6][RRM3:83%*][.RRM2:17%][KOG0127:100%*]Ostreococcus@jgi_Ostta4_19569[2][RRM3:100%][KOG0127:100%]
Chlamydomonadales@jgi_Volca1_87629[2][RRM3:100%][KOG0127:100%]Dictyostelium discoideum_AX4@XP_646584[RRM3][KOG0127]
Theileria parva_strain_Muguga@XP_765501[RRM2][KOG0127]Ciona intestinalis@ENSCINP00000018774[2][RRM3:100%][KOG0127:100%]
Caenorhabditis elegans@R05H10_2[RRM2][KOG0127]Oryzias latipes@ENSORLP00000012079[RRM3][KOG0127]
Euteleostomi@ENSGACP00000016696[19][RRM3:79%**][.RRM4:11%][.RRM1:11%][RBM:58%**][KOG0127:100%**]Strongylocentrotus purpuratus@XP_783689[2][RRM2:100%][KOG0127:100%]Endopterygota@XP_001605703[3][RRM2:67%][.RRM3:33%][KOG0127:100%*]
Drosophila melanogaster@CG4806-PA[RRM2][KOG0127]Schizosaccharomyces pombe_972h-@NP_596518[RRM1][KOG0116]
Aedes aegypti@AAEL008572-PA[RRM2][KOG0127]Phytophthora sojae@jgi_Physo1_1_132702[RRM4][KOG0127]
Phytophthora ramorum@jgi_Phyra1_1_79608[2][RRM4:100%][KOG0127:100%]Saccharomycetales@XP_001385462[7][RRM3:100%*][KOG0127:100%*]
Basidiomycota@XP_756663[3][RRM4:67%][.RRM3:33%][KOG0127:100%*]Schizosaccharomyces pombe_972h-@NP_596114[RRM3][KOG0127]
Aspergillus fumigatus_Af293@XP_752199[RRM3][KOG0127]Sordariomycetes@XP_962933[2][RRM3:100%][KOG0127:100%]
Thalassiosira pseudonana@jgi_Thaps3_1374[RRM2][KOG0116]Phytophthora@jgi_Physo1_1_136329[2][RRM2:100%][KOG0123:100%]
Aureococcus anophagefferens@jgi_Auran1_8214[RRM1]Pichia stipitis_CBS_6054@XP_001384763[RRM3][KOG0123]Dictyostelium discoideum_AX4@XP_643642[RRM2][KOG0148]
Cryptosporidium parvum_Iowa_II@XP_001388131[RRM2][KOG1015]Euteleostomi@ENSORLP00000006283[2][RRM1:100%][LA:50%][KOG1855:100%]
Euteleostomi@GSTENP00013801001[29][RRM1:100%***][LA:59%**][KOG1855:100%***]Tribolium castaneum@XP_974730[RRM1][KOG1855]
Apocrita@XP_001600355[2][RRM1:100%][KOG1855:100%]Takifugu rubripes@SINFRUP00000134535[RRM1][KOG0123]
Aspergillus fumigatus_Af293@XP_750045[RRM1]Ostreococcus lucimarinus@jgi_Ost9901_3_32831[RRM1]
Leishmania infantum_JPCM5@XP_001468615[RRM1]Embryophyta@jgi_Phypa1_1_217831[15][RRM3:93%**][.RRM1:7%][KOG0117:100%**]
Plasmodium falciparum_3D7@XP_001347479[RRM1]Debaryomyces hansenii_CBS767@XP_460681[RRM3][KOG0128]
Saccharomyces cerevisiae@YMR268C[RRM3][KOG0128]Candida glabrata_CBS138@XP_446891[RRM3][KOG0128]
Nasonia vitripennis@XP_001604488[RRM1]Phytophthora@jgi_Physo1_1_140019[2][RRM1:100%][KOG0116:100%]
Schizosaccharomyces pombe_972h-@NP_596721[RRM3][KOG0128]Aspergillus fumigatus_Af293@XP_749317[RRM3][KOG0128]
Eukaryota@NP_001053839[55][RRM6:42%***][.RRM5:35%**][.RRM4:11%*][.RRM3:9%*][KOG0110:100%****]Plasmodium falciparum_3D7@XP_001350574[RRM3][KOG0110]Cryptosporidium parvum_Iowa_II@XP_627799[RRM5][KOG0110]
Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM5][KOG0110]Encephalitozoon cuniculi_GB-M1@NP_597181[RRM3][KOG0110]
Embryophyta@jgi_Phypa1_1_201182[6][RRM2:100%*][KOG0127:100%*]Chlamydomonas reinhardtii@jgi_Chlre3_186870[RRM2][KOG0127]
Ostreococcus@jgi_Ost9901_3_26255[2][RRM2:100%][KOG0127:100%]Dictyostelium discoideum_AX4@XP_646584[RRM2][KOG0127]
Schizosaccharomyces pombe_972h-@NP_596114[RRM2][KOG0127]Pezizomycotina@XP_962933[3][RRM2:100%*][KOG0127:100%*]Saccharomycetales@XP_459044[4][RRM2:100%*][KOG0127:100%*]
Yarrowia lipolytica@XP_499726[RRM2][KOG0127]Chordata@ENSOGAP00000005376[31][RRM2:90%***][.RRM3:6%][RBM:39%**][KOG0127:100%***]
Drosophila melanogaster@CG4806-PA[RRM1][KOG0127]Aedes aegypti@AAEL008572-PA[RRM1][KOG0127]
Nasonia vitripennis@XP_001605703[RRM1][KOG0127]Tribolium castaneum@XP_974350[RRM1][KOG0127]
Nasonia vitripennis@XP_001605703[RRM2][KOG0127]Apis mellifera@XP_624495[RRM1][KOG0127]
Plasmodium falciparum_3D7@XP_001348230[RRM1][KOG0130]Yarrowia lipolytica@XP_503462[RRM1][put-sr][KOG0130]
Ustilago maydis_521@XP_760711[RRM1][put-sr][KOG0687]Cryptococcus neoformans_var._neoformans_JEC21@XP_569809[RRM1][KOG0130]
Phaeodactylum tricornutum@jgi_Phatr2_20716[RRM1][KOG0130]Eukaryota@jgi_Thaps3_18841[52][RRM1:100%***][put-sr:56%***][RBM:42%***][KOG0130:100%***]
Sordariomycetes@XP_001522188[3][RRM1:100%*][put-sr:67%]Cryptococcus neoformans_var._neoformans_JEC21@XP_569824[RRM1][put-sr]
Schizosaccharomyces pombe_972h-@NP_596549[RRM1][put-sr]Coelomata@ENSMUSP00000057332[45][RRM1:100%***][put-sr:100%***][RNPS1:64%***][KOG4209:87%***]
Caenorhabditis elegans@K02F3_11_2[2][RRM1:100%][put-sr:100%][KOG4209:100%]Dictyostelium discoideum_AX4@XP_636445[RRM1][put-sr]
Viridiplantae@jgi_Phypa1_1_105411[8][RRM1:100%**][put-sr:100%**][SR:25%][KOG0117:12%][.KOG0462:12%]Phytophthora@jgi_Physo1_1_138873[2][RRM1:100%][put-sr:100%][KOG1611:50%]
Pezizomycotina@XP_958422[3][RRM1:100%*][put-sr:33%][KOG0533:100%*]Ustilago maydis_521@XP_757147[RRM1][KOG0533]
Plasmodium falciparum_3D7@XP_966143[RRM1][KOG0533]Theileria parva_strain_Muguga@XP_764636[RRM1]
Yarrowia lipolytica@XP_505140[RRM1][KOG0533]Eukaryota@GSTENP00007343001[69][RRM1:100%****][FCAFPA:10%*][KOG0533:99%****]
Ostreococcus tauri@jgi_Ostta4_36431[RRM1][KOG0533]Dictyostelium discoideum_AX4@XP_638266[RRM1][KOG0533]
Chlamydomonadales@jgi_Volca1_90392[2][RRM1:100%][KOG0533:100%]Phytophthora@jgi_Phyra1_1_97175[2][RRM1:100%][put-sr:50%][KOG0533:100%]
Cyanidioschyzon merolae@gnl_CMER_CMH135C[RRM1]Euteleostomi@ENSTBEP00000009485[3][RRM1:100%*][PDIP:33%][KOG0533:33%]
Endopterygota@CG6961-PA[7][RRM1:100%*][KOG0533:29%]Saccharomycetales@XP_462132[6][RRM1:100%*][KOG0533:100%*]
Plasmodium falciparum_3D7@XP_001352162[RRM1]Plasmodium falciparum_3D7@XP_001351468[RRM1]
Schizosaccharomyces pombe_972h-@NP_595715[RRM1][KOG0533]Sordariomycetes@XP_956471[2][RRM1:100%][KOG0533:100%]
Ustilago maydis_521@XP_760032[RRM1][KOG0533]Cryptococcus neoformans_var._neoformans_JEC21@XP_572037[RRM1][KOG0533]
Dictyostelium discoideum_AX4@XP_642758[RRM1]Cyanidioschyzon merolae@gnl_CMER_CMT598C[RRM1][KOG0148]
Leptospira@YP_001385[4][RRM1:100%*][PROK:100%*]Ciona@ENSCINP00000009845[4][RRM1:100%*][KOG0116:100%*]
Deuterostomia@ENSMODP00000011218[78][RRM1:100% ][G3BP:82% ][KOG0116:100% ] p
Part of 30 - PDIP
FCA FPA
26 - SR45
27 - RNPS128
20 - RBM
71 - RBM
60
Part of 63 - hnRNP
81 - La
72 - RBM
87 - eIF-4B
Fungal SpRnps1
Fig. S8
107
75
54
75
65
80
72
66
77
63
Viridiplantae@jgi Phypa1 1 207810[3][RRM1:100%*][KOG0110:100%*]Dictyostelium discoideum_AX4@XP_638463[RRM1][KOG0110]
Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM1][KOG0110]Ustilago maydis_521@XP_758493[RRM1][KOG0110]
Saccharomycetaceae@XP_001386803[2][RRM1:100%][KOG0110:100%]Aspergillus fumigatus_Af293@XP_748929[RRM1]
Neurospora crassa_OR74A@XP_964541[RRM1]Theileria parva_strain_Muguga@XP_766096[RRM1]
Chlamydomonadales@jgi_Volca1_54847[2][RRM1:100%][KOG0108:100%]Physcomitrella patens@jgi_Phypa1_1_167900[3][RRM1:100%*][KOG0123:33%][.KOG4210:33%][.KOG1015:33%]
Ostreococcus tauri@jgi_Ostta4_10328[RRM1][KOG2476]Arabidopsis thaliana@NP_175125[7][RRM1:43%*][.RRM2:29%][.RRM4:14%][.RRM3:14%][PABP:29%][KOG0123:100%*]
Magnoliophyta@NP_001053909[5][RRM1:100%*][nucleolin:40%][KOG0123:40%][.KOG4210:40%][.KOG1015:20%]stramenopiles@jgi_Auran1_17857[4][RRM1:50%][.RRM2:50%][KOG0108:50%][.KOG4205:50%]
Phaeodactylum tricornutum@jgi_Phatr2_49387[RRM1]Aureococcus anophagefferens@jgi_Auran1_9434[RRM1]
Ostreococcus lucimarinus@jgi_Ost9901_3_92667[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_569209[RRM2][KOG0144]Thalassiosira pseudonana@jgi_Thaps3_24369[RRM1]
Phaeodactylum tricornutum@jgi_Phatr2_44442[RRM1][KOG4211]Phytophthora@jgi_Phyra1_1_76845[2][RRM1:100%][KOG0123:100%]
Phaeodactylum tricornutum@jgi_Phatr2_44395[RRM1]Poaceae@8373_m000321_c0161G04[2][RRM1:100%][KOG4205:50%][.KOG4211:50%]
Volvox carteri@jgi_Volca1_90315[RRM1]Mammalia@ENSETEP00000003776[19][RRM1:100%**][LA:95%**][KOG4213:100%**]
Embryophyta@28180_m000395[3][RRM1:100%*][KOG0124:100%*]Arabidopsis thaliana@NP_191094[RRM1][KOG4205]
Aureococcus anophagefferens@jgi_Auran1_71372[2][RRM3:50%][.RRM2:50%][put-sr:100%][KOG1178:100%]Phytophthora@jgi_Phyra1_1_77488[2][RRM1:100%][KOG4205:100%]
Phytophthora sojae@jgi_Physo1_1_139998[RRM1]Caenorhabditis elegans@W02D3_11b[2][RRM1:100%][KOG4211:100%]
Coelomata@ENSCINP00000003632[126][RRM2:70%****][.RRM1:30%***][hnRNP:37%***][.GRSRBP:15%**][KOG4211:100%****]Danio rerio@ENSDARP00000069459[RRM2][KOG4211]
Volvox carteri@jgi_Volca1_117772[RRM1][KOG1365]Caenorhabditis elegans@Y73B6BL_33[RRM1][KOG4211]
Physcomitrella patens@jgi_Phypa1_1_162342[RRM3][KOG1365]Ciona savignyi@ENSCSAVP00000001587[RRM5][KOG4307]
Oryzias latipes@ENSORLP00000025180[RRM2][put-sr][KOG4307]Plasmodium falciparum_3D7@XP_001347519[RRM1][KOG1365]
Arabidopsis thaliana@NP_188725[RRM2][hnRNP][KOG1365]Thalassiosira pseudonana@jgi_Thaps3_5686[RRM2][KOG4211]
Saccharomycetales@NP_982813[6][RRM2:100%*][KOG4210:100%*]Aspergillus fumigatus_Af293@XP_755020[RRM2]
Schizosaccharomyces pombe_972h-@NP_594970[RRM2][KOG4210]Yarrowia lipolytica@XP_499736[RRM2][KOG4205]
Caenorhabditis elegans@R09B3_3[3][RRM1:100%*][KOG0108:100%*]Phytophthora@jgi_Phyra1_1_83430[2][RRM1:100%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_566745[2][RRM1:100%]Pichia stipitis_CBS_6054@XP_001384729[RRM1]
Yarrowia lipolytica@XP_504609[RRM1]Neurospora crassa_OR74A@XP_965346[RRM2][KOG0110]
Aspergillus fumigatus_Af293@XP_747328[RRM2][KOG0110]Euteleostomi@GSTENP00022906001[41][RRM3:83%***][.RRM2:10%*][.RRM1:7%*][nucleolin:54%***][KOG0123:93%***]
Tetraodontidae@GSTENP00014994001[2][RRM1:50%][.RRM3:50%][KOG0123:50%]Euteleostomi@ENSMODP00000021210[32][RRM2:97%***][nucleolin:59%**][KOG0123:100%***]
Ciona@ENSCINP00000008105[4][RRM1:100%*][KOG0116:50%][.KOG2141:25%]Pezizomycotina@XP_754840[2][RRM2:100%][KOG0127:50%][.KOG0148:50%]
Aspergillus fumigatus_Af293@XP_754657[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_566835[RRM2][KOG0148]
Ustilago maydis_521@XP_762340[RRM2][KOG0148]Schizosaccharomyces pombe_972h-@NP_593531[RRM2][nucleolin][KOG0147]Saccharomycetales@XP_456900[7][RRM2:100%*][nucleolin:14%][KOG0148:57%*][.KOG0131:29%][.KOG4210:14%]
Drosophila melanogaster@CG12288-PA[RRM2]Culicidae@AGAP003171-PA[3][RRM2:100%*][KOG0148:33%]
Chlamydomonadales@jgi_Volca1_120471[2][RRM1:100%][KOG0108:100%]Ciona intestinalis@ENSCINP00000024280[RRM1][KOG0113]
Cyanidioschyzon merolae@gnl_CMER_CMO334C[RRM2][KOG0126]Ascomycota@XP_505055[6][RRM1:83%*][.RRM2:17%]
Trypanosomatidae@XP_827554[2][RRM1:50%][.RRM2:50%][put-sr:50%]Phaeodactylum tricornutum@jgi_Phatr2_46145[RRM2]
Apis mellifera@XP_394565[RRM2][KOG0147]Coelomata@ENSDARP00000093407[32][RRM2:88%***][.RRM1:12%*][KOG0108:12%*][.KOG3001:6%][.KOG0123:6%][.KOG0126:6%]
Volvox carteri@jgi_Volca1_118759[RRM2]Ostreococcus@jgi_Ostta4_30189[2][RRM1:50%][.RRM2:50%][put-sr:50%]
Magnoliophyta@30054_m000807[2][RRM2:100%][KOG1267:50%]Dictyostelium discoideum_AX4@XP_635997[RRM2]
Caenorhabditis elegans@F11A10_7[RRM2][KOG0131]Ciona@ENSCSAVP00000005375[4][RRM2:75%*][.RRM1:25%][KOG0116:75%*][.KOG2141:25%]
Encephalitozoon cuniculi_GB-M1@NP_597583[RRM1][KOG4205]Physcomitrella patens@jgi_Phypa1_1_188347[RRM2][KOG0123]
Physcomitrella patens@jgi_Phypa1_1_167900[RRM2][KOG1015]Magnoliophyta@29675_m000389[3][RRM2:100%*][KOG0123:67%][.KOG1015:33%]
Arabidopsis thaliana@NP_188491[RRM2][nucleolin][KOG4210]Dictyostelium discoideum_AX4@XP_638966[RRM1][KOG0147]
Phytophthora@jgi_Physo1_1_157186[2][RRM1:100%][KOG0147:100%]Strongylocentrotus purpuratus@XP_001198098[2][RRM1:100%][put-sr:100%][KOG0147:100%]Eukaryota@ENSMLUP00000011758[47][RRM1:100%***][put-sr:91%***][UMH:64%***][.CAPER:15%*][KOG0147:100%***]
Ascomycota@NP_594422[4][RRM1:100%*][put-sr:100%*][KOG0147:100%*]Yarrowia lipolytica@XP_504318[RRM1][KOG0147]
Ostreococcus@jgi_Ost9901_3_42846[2][RRM1:100%][put-sr:50%][KOG0147:100%]Volvox carteri@jgi_Volca1_84128[2][RRM1:100%][put-sr:50%][KOG0147:100%]
Cryptosporidium parvum_Iowa_II@XP_628665[RRM1][KOG0147]Plasmodium falciparum_3D7@XP_001349956[RRM1][KOG0147]
Chlamydomonadales@jgi_Volca1_90315[3][RRM2:67%][.RRM3:33%][KOG0123:67%]Chordata@ENSETEP00000010530[36][RRM1:50%**][.RRM2:50%**][put-sr:100%***][SRrp:75%***][KOG4676:100%***]
Magnoliophyta@15974_m000013_AZM5_17589[3][RRM2:67%][.RRM1:33%]Caenorhabditis elegans@T08B6_5[RRM1][KOG4209]
Caenorhabditis elegans@EEED8_12[2][RRM1:100%][KOG4209:100%]Eukaryota@ENSCSAVP00000003369[89][RRM1:100%****][put-sr:17%**][PABP:26%***][KOG4209:100%****]
Dictyostelium discoideum_AX4@XP_642788[RRM1][KOG4209]Ciona@ENSCSAVP00000010162[2][RRM1:100%][KOG4209:100%]
Magnoliophyta@IMGA_AC160842_25_1[6][RRM1:100%*][KOG3702:83%*][.KOG4209:17%]Physcomitrella patens@jgi_Phypa1_1_167236[RRM1][KOG4209]
Arabidopsis thaliana@NP_180012[RRM1]Volvox carteri@jgi_Volca1_103724[RRM1][put-sr][KOG0591]
Aedes aegypti@AAEL012119-PA[RRM1]Apocrita@XP_001602582[2][RRM1:100%][KOG0128:100%]
Euteleostomi@ENSSTOP00000002132[31][RRM1:100%***][SART3:68%***][KOG0128:100%***]Strongylocentrotus purpuratus@XP_781643[RRM1][KOG0128]
Ciona intestinalis@ENSCINP00000019832[3][RRM1:100%*][KOG0128:100%*]Tribolium castaneum@XP_972538[RRM1][KOG0128]Culicidae@AAEL011961-PA[3][RRM1:100%*][KOG0128:100%*]
Schizosaccharomyces pombe_972h-@NP_595728[RRM1]Ostreococcus@jgi_Ost9901_3_31221[2][RRM1:100%][KOG0128:100%]
Magnoliophyta@29609_m000574[4][RRM1:100%*][KOG0128:100%*]Physcomitrella patens@jgi_Phypa1_1_135986[RRM1][KOG0128]
Ustilago maydis_521@XP_762237[RRM1]Aspergillus fumigatus_Af293@XP_755976[RRM1]
Sordariomycetes@XP_956776[2][RRM1:100%][put-sr:50%]Coelomata@XP_001182806[39][RRM1:100% ][KOG0108:13% ][.KOG0116:8% ][.KOG0921:5%]
73 - SART3
74
83 - PABP
75 - CAPER
UMH
85 - SRrp
80 - hnRNP
84 - La
Fig. S8
108
81 94
93
77
52 68
99
57
94
94
67
54
62
62
57
Pezizomycotina@XP 755630[3][RRM1:100%*][KOG0111:100%*]Cryptococcus neoformans_var._neoformans_JEC21@XP_566572[RRM1][KOG0111]
Plasmodium falciparum_3D7@XP_001349948[RRM1][KOG0111]Theileria parva_strain_Muguga@XP_765867[RRM1][KOG0111]
Eukaryota@ENSGALP00000021793[59][RRM1:100%****][cyclophilin:59%***][KOG0111:98%****]Eutheria@ENSEEUP00000009324[3][RRM1:100%*][cyclophilin:100%*][KOG0111:100%*]Otolemur garnettii@ENSOGAP00000003225[RRM1][KOG0111]Deuterostomia@ENSXETP00000012868[47][RRM1:100%***][KOG4454:60%***][.KOG0131:40%**]
Endopterygota@AGAP002256-PA[4][RRM1:100%*][KOG4454:75%*][.KOG0131:25%]Drosophila melanogaster@CG11454-PA[RRM1][KOG4454]
Magnoliophyta@NP_001055607[4][RRM1:100%*][put-sr:25%][KOG0131:100%*]Caenorhabditis elegans@Y37D8A_21_1[2][RRM1:100%][KOG4454:100%]
Cryptosporidium parvum_Iowa_II@XP_627780[RRM1][KOG0131]Plasmodium falciparum_3D7@XP_001348367[RRM1][KOG0131]
Eukaryota@NP_001064759[59][RRM1:100%****][snRNP:8%*][KOG0131:100%****]Saccharomycetaceae@XP_001385635[2][RRM1:100%][KOG0131:100%]
Dictyostelium discoideum_AX4@XP_647248[RRM1][KOG0131]Ashbya gossypii_ATCC_10895@NP_982888[RRM1][KOG0131]
Candida glabrata_CBS138@XP_447678[RRM1][KOG0131]Saccharomyces cerevisiae@YOR319W[RRM1][KOG0131]
Percomorpha@ENSGACP00000007987[5][RRM1:100%*][IGF2BP:80%*][KOG2193:100%*]Strongylocentrotus purpuratus@XP_001180991[4][RRM1:100%*]
Percomorpha@ENSGACP00000011877[6][RRM1:100%*][KOG0123:100%*]Gallus gallus@ENSGALP00000012472[2][RRM1:100%][KOG0123:100%]
Physcomitrella patens@jgi_Phypa1_1_93324[RRM1]Trypanosomatidae@XP_847474[2][RRM1:100%]Trypanosomatidae@XP_001467105[2][RRM1:100%][KOG4209:100%]
Saccharomycetaceae@XP_453677[2][RRM1:100%][KOG4209:100%]Saccharomyces cerevisiae@YIR001C[RRM1][PABP][KOG4209]
Candida glabrata_CBS138@XP_447800[RRM1][KOG4209]Embryophyta@jgi_Phypa1_1_161416[4][RRM1:100%*][put-sr:75%*][KOG0154:75%*][.KOG0147:25%]
Encephalitozoon cuniculi_GB-M1@NP_586226[RRM1][put-sr][KOG0123]Dictyostelium discoideum_AX4@XP_645848[RRM2][put-sr]
Arabidopsis thaliana@NP_974808[2][RRM1:100%][KOG0123:50%][.KOG0148:50%]Ustilago maydis_521@XP_758439[RRM3][KOG0123]
Caenorhabditis elegans@F56D1_7[RRM1]Takifugu rubripes@SINFRUP00000155469[RRM1]
Coelomata@AAEL001684-PA[39][RRM1:100%***][KOG0125:21%**]Euteleostomi@ENSEEUP00000005436[64][RRM1:95%****]
Tupaia belangeri@ENSTBEP00000015084[RRM1]Spermophilus tridecemlineatus@ENSSTOP00000003171[RRM1]
Amniota@ENSMODP00000004174[11][RRM4:55%*][.RRM3:36%*][.RRM2:9%][put-sr:100%**][KOG0112:100%**]Dictyostelium discoideum_AX4@XP_646990[RRM1][put-sr][KOG0147]
Theileria parva_strain_Muguga@XP_766400[RRM2][put-sr][KOG4205]Strongylocentrotus purpuratus@XP_001185731[2][RRM1:100%]
Tribolium castaneum@XP_971953[RRM1]Euteleostomi@ENSMODP00000018834[25][RRM1:100%***][put-sr:64%**][KOG0147:48%**][.KOG0132:12%*]
Eutheria@ENSMLUP00000005283[2][RRM1:100%][put-sr:100%]Spermophilus tridecemlineatus@ENSSTOP00000006011[RRM1][put-sr]
Dictyostelium discoideum_AX4@XP_642304[RRM1][KOG0415]Aedes aegypti@AAEL004293-PA[RRM1][put-sr]
Coelomata@AGAP006798-PA[81][RRM1:100%****][put-sr:99%****][KOG0122:26%***][.KOG0125:25%**][.KOG0147:14%**][.KOG0108:9%*]Drosophila melanogaster@CG10128-PC[6][RRM1:100%*][put-sr:100%*]Basidiomycota@XP_757472[3][RRM1:100%*][put-sr:33%][KOG0122:33%]Caenorhabditis elegans@C18D11_4_1[2][RRM1:100%][put-sr:100%][KOG0921:100%]
Encephalitozoon cuniculi_GB-M1@NP_585779[RRM1]Saccharomycetaceae@XP_458658[2][RRM1:100%][KOG0921:100%]
Physcomitrella patens@jgi_Phypa1_1_12664[RRM1]rosids@30155_m001644[2][RRM1:100%][KOG0116:50%]
Euteleostomi@ENSDARP00000069729[82][RRM1:100%****][KOG1995:77%****][.KOG0921:16%**][.KOG2044:5%*]Endopterygota@XP_624681[6][RRM1:100%*][put-sr:17%][KOG0921:67%*][.KOG1548:33%]
Strongylocentrotus purpuratus@XP_001196853[2][RRM1:100%][KOG1995:100%]Arabidopsis thaliana@NP_564565[RRM1][put-sr][KOG1995]
Cryptosporidium parvum_Iowa_II@XP_001388131[RRM1][KOG1015]Theileria parva_strain_Muguga@XP_765374[RRM1]
Dictyostelium discoideum_AX4@XP_643642[RRM1][KOG0148]Ostreococcus tauri@jgi_Ostta4_34258[RRM2]
Saccharomycetaceae@XP_001383390[2][RRM1:100%][KOG0108:100%]Oryza sativa_japonica_cultivar-group@NP_001058465[RRM1][KOG0108]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572946[RRM1][KOG0108]Aureococcus anophagefferens@jgi_Auran1_23269[RRM1][KOG0108]
Bacillariophyta@jgi_Phatr2_8451[2][RRM1:100%][KOG0108:100%]Kluyveromyces lactis@XP_453283[RRM2][KOG0123]
Dikarya@NP_596771[2][RRM1:100%][KOG0108:50%]Tribolium castaneum@XP_969008[RRM2][KOG0331]
Cryptosporidium parvum_Iowa_II@XP_627975[RRM1][KOG0108]Plasmodium falciparum_3D7@XP_001352196[RRM1][KOG0108]
Aureococcus anophagefferens@jgi_Auran1_17171[RRM1][KOG0108]Eukaryota@ENSDARP00000064611[84][RRM1:100%****][KOG0108:99%****]
Encephalitozoon cuniculi_GB-M1@NP_597167[RRM1][KOG0108]Ostreococcus tauri@jgi_Ostta4_31925[RRM1][KOG0117]
Viridiplantae@29631_m001006[3][RRM1:100%*][put-sr:33%][KOG0108:67%][.KOG2253:33%]Euteleostomi@ENSGACP00000016390[7][RRM1:100%*][put-sr:86%*][RBM:14%][KOG2253:100%*]
Schizosaccharomyces pombe_972h-@NP_595396[RRM1][put-sr][KOG0120]Chlamydomonadales@jgi_Volca1_48801[2][RRM1:100%][KOG0120:100%]
Plasmodium falciparum_3D7@XP_001348830[RRM2][put-sr][KOG0120]Phaeodactylum tricornutum@jgi_Phatr2_11145[RRM2][KOG0120]
Eukaryota@jgi_Volca1_82970[75][RRM2:91%****][.RRM1:9%*][put-sr:80%****][snRNP:53%***][KOG0120:100%****]Pezizomycotina@XP_387225[3][RRM1:67%][.RRM2:33%][put-sr:100%*][KOG0120:100%*]
Yarrowia lipolytica@XP_503754[RRM1][KOG0120]Trypanosoma brucei_TREU927@XP_829593[RRM1]
Ostreococcus@jgi_Ost9901_3_7913[3][RRM1:100%*][KOG0131:33%]Viridiplantae@jgi_Chlre3_99594[25][RRM1:100%***][KOG0123:8%]
Ostreococcus tauri@jgi_Ostta4_24260[RRM1]Magnoliophyta@NP_189032[4][RRM1:100%*][put-sr:100%*][KOG0670:100%*]
Aureococcus anophagefferens@jgi_Auran1_66158[RRM1][put-sr][KOG0149]Aureococcus anophagefferens@jgi_Auran1_67810[RRM1][put-sr][KOG0120]
Trypanosomatidae@XP_827855[2][RRM1:100%]Kluyveromyces lactis@XP_454447[RRM3][KOG0128]
Saccharomyces cerevisiae@YMR268C[RRM1][KOG0128]Cryptosporidium parvum_Iowa_II@XP_627232[RRM1][put-sr][KOG0105]
Plasmodium falciparum_3D7@XP_966051[RRM2]Ostreococcus lucimarinus@jgi_Ost9901_3_28918[RRM1]
Plasmodium falciparum_3D7@XP_966051[RRM1]Encephalitozoon cuniculi_GB-M1@XP_965888[RRM1][KOG4209]
Neurospora crassa_OR74A@XP_960450[RRM1]Pichia stipitis_CBS_6054@XP_001384763[RRM1][KOG0123]
Trypanosoma brucei_TREU927@XP_951655[RRM3][put-sr][KOG0109]Leishmania infantum_JPCM5@XP_001466413[RRM2][put-sr][KOG0147]
Trypanosoma brucei_TREU927@XP_951655[RRM2][put-sr][KOG0109]Trypanosomatidae@XP_827358[2][RRM2:100%][KOG0123:100%]
Encephalitozoon cuniculi_GB-M1@NP_597181[RRM1][KOG0110]Schizosaccharomyces pombe_972h-@NP_595599[RRM1][KOG0110]
Drosophila melanogaster@CG3335-PA[RRM1][KOG0110]Apocrita@XP_624611[2][RRM1:100%][KOG0110:100%]
Caenorhabditis elegans@T23F6_4_1[2][RRM1:100%][KOG0110:100%]Culicidae@AGAP005249-PA[2][RRM1:100%][KOG0110:100%]
Euteleostomi@GSTENP00029551001[21][RRM1:100%***][put-sr:10%][KOG0110:100%***]Arabidopsis thaliana@NP_196191[RRM1][KOG0110]
Viridiplantae@jgi_Phypa1_1_207810[3][RRM1:100% ][KOG0110:100% ]
1
64 - snRNP
61
46
47
48 - IGF2BP
19 - cyclophilin
49
Fig. S8
109
91
61
91
64
85
97
81
79
72
61
73
87
90 81
79 50
64
Phytophthora sojae@jgi Physo1 1 138511[RRM1][put-sr]Kluyveromyces lactis@XP_451368[RRM3][KOG0123]
Ashbya gossypii_ATCC_10895@NP_984845[RRM3][KOG0123]Saccharomyces cerevisiae@YHR015W[RRM3][KOG0123]
Saccharomyces cerevisiae@YFR023W[RRM3][KOG0123]Candida glabrata_CBS138@XP_447635[RRM3][KOG0123]
Neurospora crassa_OR74A@XP_965346[RRM1][KOG0110]Phytophthora@jgi_Physo1_1_132702[3][RRM3:100%*][KOG0127:100%*]
Cyanidioschyzon merolae@gnl_CMER_CMO246C[RRM2][KOG0110]Anopheles gambiae@AGAP007689-PA[RRM1]
Aedes aegypti@AAEL010101-PA[RRM1]Saccharomycetales@NP_986417[7][RRM1:100%*][KOG0127:100%*]
Schizosaccharomyces pombe_972h-@NP_596114[RRM1][KOG0127]Basidiomycota@XP_568669[3][RRM1:100%*][KOG0127:100%*]
Euteleostomi@ENSOANP00000001262[28][RRM1:100%***][RBM:46%**][KOG0127:100%***]Sordariomycetes@XP_382687[2][RRM1:100%][KOG0127:100%]
Aspergillus fumigatus_Af293@XP_752199[RRM1][KOG0127]Phytophthora@jgi_Physo1_1_132702[3][RRM1:100%*][KOG0127:100%*]
Ostreococcus tauri@jgi_Ostta4_19569[RRM1][KOG0127]Ostreococcus lucimarinus@jgi_Ost9901_3_26255[RRM1][KOG0127]
Ciona@ENSCINP00000018772[3][RRM1:100%*][KOG0127:100%*]Magnoliophyta@NP_565513[6][RRM1:100%*][KOG0127:100%*]
Physcomitrella patens@jgi_Phypa1_1_201182[RRM1][KOG0127]Chlamydomonadales@jgi_Chlre3_186870[2][RRM1:100%][KOG0127:100%]
Dictyostelium discoideum_AX4@XP_646584[RRM1][KOG0127]Saccharomycetaceae@XP_001388004[2][RRM1:100%][KOG0122:100%]
Saccharomycetales@XP_446998[3][RRM1:100%*][KOG0122:100%*]Dictyostelium discoideum_AX4@XP_641693[RRM1][KOG0122]
Yarrowia lipolytica@XP_503515[RRM1][KOG0122]Cryptococcus neoformans_var._neoformans_JEC21@XP_567824[RRM1][KOG0122]Cyanidioschyzon merolae@gnl_CMER_CMH159C[RRM1][KOG0122]
Caenorhabditis elegans@F22B5_2[RRM1][KOG0122]Apicomplexa@XP_001388056[3][RRM1:100%*][KOG0122:100%*]
Eukaryota@NP_187747[49][RRM1:100%***][KOG0122:98%***]Medicago truncatula@IMGA_AC144431_18_2[RRM1][KOG0122]
Phaeodactylum tricornutum@jgi_Phatr2_8457[RRM1][KOG0122]Cryptosporidium parvum_Iowa_II@XP_626158[RRM1][KOG0144]
Volvox carteri@jgi_Volca1_63158[RRM2][KOG0110]Phytophthora@jgi_Phyra1_1_74707[2][RRM3:100%][KOG0110:100%]
Oryza sativa_japonica_cultivar-group@NP_001053839[RRM1][KOG0110]Trypanosomatidae@XP_001463723[2][RRM1:100%][KOG0110:100%]
Phytophthora@jgi_Physo1_1_129427[2][RRM2:100%][KOG0110:100%]Cyanidioschyzon merolae@gnl_CMER_CML202C[RRM1][put-sr]Theileria parva_strain_Muguga@XP_765501[RRM1][KOG0127]
Thalassiosira pseudonana@jgi_Thaps3_268689[RRM2][KOG0110]Encephalitozoon cuniculi_GB-M1@NP_584580[RRM1][KOG0114]Eukaryota@jgi_Phatr2_8132[54][RRM1:100%***][KOG0114:100%***]
Debaryomyces hansenii_CBS767@XP_458197[RRM1][KOG0114]Schizosaccharomyces pombe_972h-@NP_594609[RRM1][KOG4660]
Eukaryota@IMGA_AC183923_6_1[34][RRM3:74%***][.RRM1:15%*][.RRM2:12%*][put-sr:6%][KOG0110:100%***]Ustilago maydis_521@XP_758493[RRM2][KOG0110]
Aureococcus anophagefferens@jgi_Auran1_1296[RRM1][KOG0110]Phaeodactylum tricornutum@jgi_Phatr2_20740[RRM2][KOG0110]
Neurospora crassa_OR74A@XP_965014[RRM2][KOG0110]Cryptococcus neoformans_var._neoformans_JEC21@XP_569873[RRM2][KOG0110]Caenorhabditis elegans@T23F6_4_1[2][RRM3:100%][KOG0110:100%]
Schizosaccharomyces pombe_972h-@NP_595599[RRM2][KOG0110]Aspergillus fumigatus_Af293@XP_750233[RRM2][KOG0110]
Saccharomycetales@NP_984131[7][RRM2:100%*][KOG0110:100%*]Dictyostelium discoideum_AX4@XP_639372[RRM1][KOG0670]Ostreococcus lucimarinus@jgi_Ost9901_3_26750[RRM1]
Embryophyta@NP_001062111[8][RRM1:100%**][put-sr:62%*][KOG4849:38%*][.KOG4246:12%][.KOG0113:12%][.KOG4676:12%]Saccharomycetales@XP_455897[3][RRM1:100%*][KOG0123:67%]
Cryptosporidium parvum_Iowa_II@XP_627799[RRM2][KOG0110]Dictyostelium discoideum_AX4@XP_629950[RRM1][KOG0128]
Ciona intestinalis@ENSCINP00000019833[3][RRM2:100%*][KOG0128:100%*]Culicidae@AAEL011963-PA[3][RRM2:100%*][KOG0128:100%*]
Strongylocentrotus purpuratus@XP_781643[RRM2][KOG0128]Tribolium castaneum@XP_972538[RRM2][KOG0128]Euteleostomi@ENSOCUP00000014007[29][RRM2:97%***][SART3:69%**][KOG0128:100%***]
Apocrita@XP_001602582[2][RRM2:100%][KOG0128:100%]Drosophila melanogaster@CG2050-PA[RRM2]
Apocrita@XP_001602363[2][RRM1:100%][KOG1832:50%]Culicidae@AAEL001997-PA[2][RRM1:100%]
Drosophila melanogaster@CG3594-PA[RRM1][KOG0110]Schizosaccharomyces pombe_972h-@NP_596033[RRM1]Cryptococcus neoformans_var._neoformans_JEC21@XP_570477[RRM1]
Phytophthora@jgi_Physo1_1_136292[2][RRM1:100%]Phaeodactylum tricornutum@jgi_Phatr2_32836[RRM1]
Neurospora crassa_OR74A@XP_964518[RRM1]Sordariomycetes@XP_389032[2][RRM1:100%]
Culicidae@AAEL004075-PA[3][RRM5:67%][.RRM1:33%][KOG0110:100%*]Ostreococcus@jgi_Ost9901_3_710[2][RRM4:100%][KOG0110:100%]
Magnoliophyta@NP_193696[2][RRM3:100%][KOG0110:100%]Thalassiosira pseudonana@jgi_Thaps3_268689[RRM4][KOG0110]
Phaeodactylum tricornutum@jgi_Phatr2_20740[RRM4][KOG0110]Euteleostomi@ENSGALP00000013474[20][RRM5:85%**][.RRM4:5%][.RRM3:5%][.RRM2:5%][put-sr:10%][KOG0110:100%**]
Phytophthora sojae@jgi_Physo1_1_129427[RRM4][KOG0110]Apocrita@XP_001605134[2][RRM5:100%][KOG0110:100%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569873[RRM4][KOG0110]Cryptosporidium parvum_Iowa_II@XP_627799[RRM4][KOG0110]Ascomycota@XP_001386803[10][RRM4:90%**][.RRM2:10%][KOG0110:100%**]
Saccharomycetaceae@XP_001385249[2][RRM1:100%][KOG0113:100%]Saccharomycetales@NP_984033[3][RRM1:100%*][KOG0113:100%*]Kluyveromyces lactis@XP_452557[RRM1][KOG0113]
Yarrowia lipolytica@XP_503802[RRM1][KOG0113]Leishmania infantum_JPCM5@XP_001464648[RRM1][KOG0113]
Apis mellifera@XP_623573[RRM1][KOG0113]Dictyostelium discoideum_AX4@XP_641373[RRM1][put-sr]
Debaryomyces hansenii_CBS767@XP_459815[RRM1][KOG0415]Eukaryota@jgi_Ostta4_3181[66][RRM1:100%****][put-sr:47%***][cyclophilin:32%***][KOG0415:97%****]
Embryophyta@29657_m000467[4][RRM1:100%*][put-sr:50%][snRNP:25%][KOG0113:100%*]Tribolium castaneum@XP_966565[RRM1][KOG0113]
Deuterostomia@XP_001178221[30][RRM1:100%***][put-sr:63%**][snRNP:70%***][KOG0113:100%***]Ciona@ENSCSAVP00000001345[2][RRM1:100%][KOG0113:100%]
Phytophthora@jgi_Phyra1_1_44765[2][RRM1:100%][put-sr:50%][KOG0113:100%]Coelomata@AAEL011340-PB[2][RRM1:100%][put-sr:50%][KOG0113:100%]
Rattus norvegicus@ENSRNOP00000048879[RRM1][snRNP][KOG0113]Felis catus@ENSFCAP00000006212[RRM1][put-sr][KOG0113]
Schizosaccharomyces pombe_972h-@NP_593779[RRM1][KOG0113]Sordariomycetes@XP_959061[2][RRM1:100%][KOG0113:100%]
Aspergillus fumigatus_Af293@XP_753306[RRM1][KOG0113]Eukaryota@jgi_Physo1_1_143842[43][RRM1:100%***][put-sr:47%**][snRNP:14%*][KOG0113:100%***]
Ostreococcus@jgi_Ostta4_11066[2][RRM1:100%][KOG0113:100%]Aureococcus anophagefferens@jgi_Auran1_34517[2][RRM1:100%][put-sr:50%][KOG0113:100%]
Cryptosporidium parvum_Iowa_II@XP_627471[RRM1][KOG0113]Phytophthora ramorum@jgi_Phyra1_1_76171[2][RRM1:100%][KOG0111:100%]
Thalassiosira pseudonana@jgi_Thaps3_31121[RRM1][KOG0111]Phaeodactylum tricornutum@jgi_Phatr2_11308[RRM1][KOG0111]Pezizomycotina@XP_755630[3][RRM1:100% ][KOG0111:100% ]
38 - Cyclophilin
36 - snRNP
37 - SART3
39
59
Part of 32
Part of 32
44
65
70 - RBM
22 - single RRM
SR proteins
Fig. S8
110
50
69
59
87 78
69
67
77
52
53 63
Thalassiosira pseudonana@jgi Thaps3 37126[RRM2][KOG0123]Phytophthora@jgi_Phyra1_1_75500[2][RRM3:100%][KOG0123:100%]
Cyanidioschyzon merolae@gnl_CMER_CMM078C[RRM2][KOG4212]Trypanosomatidae@XP_001465100[2][RRM2:100%][KOG4212:100%]
Saccharomycetales@XP_446962[5][RRM1:100%*][put-sr:60%*][KOG0127:60%*][.KOG0123:40%]Saccharomycetaceae@XP_462023[2][RRM1:100%][put-sr:100%][KOG0123:100%]
Saccharomycetaceae@XP_453283[2][RRM1:50%][.RRM2:50%][KOG0123:50%][.KOG0127:50%]Saccharomyces cerevisiae@YNL004W[RRM2][KOG0127]
Saccharomycetales@XP_445179[2][RRM2:100%][put-sr:100%][KOG0123:100%]Candida glabrata_CBS138@XP_446962[RRM2][put-sr][KOG0127]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572539[4][RRM2:100%*][KOG4212:100%*]Basidiomycota@XP_758699[7][RRM1:71%*][.RRM2:29%][put-sr:14%][KOG4212:100%*]Saccharomycetales@XP_001386572[3][RRM2:67%][.RRM1:33%][put-sr:67%][KOG0123:67%][.KOG4212:33%]
Chlamydomonadales@jgi_Volca1_103054[2][RRM3:50%][.RRM2:50%][KOG0055:50%]Coelomata@ENSMLUP00000006206[100][RRM2:88%****][.RRM1:12%**][put-sr:5%*][hnRNP:28%***][KOG4212:98%****]
Caenorhabditis elegans@C25A1_4_2[2][RRM2:100%][put-sr:100%][KOG4212:100%]Schizosaccharomyces pombe_972h-@NP_594207[RRM2][KOG4212]
Plasmodium falciparum_3D7@XP_001347353[RRM2][KOG4212]Pezizomycotina@XP_751108[2][RRM2:100%][put-sr:100%][KOG4212:100%]
Trypanosomatidae@XP_001465100[2][RRM1:100%][KOG4212:100%]Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM2][put-sr][KOG0147]
Saccharomycetales@YNL004W[4][RRM3:100%*][put-sr:50%][KOG0123:50%][.KOG0127:50%]Saccharomycetales@XP_888678[3][RRM3:67%][.RRM2:33%][put-sr:67%][KOG0123:67%][.KOG4212:33%]
Dikarya@XP_568231[5][RRM3:100%*][put-sr:80%*][KOG4212:80%*][.KOG0147:20%]Yarrowia lipolytica@XP_503927[RRM3][put-sr][KOG4212]
Yarrowia lipolytica@XP_505724[RRM1][KOG4198]Caenorhabditis elegans@ZC404_8_2[2][RRM1:100%][KOG0125:100%]
Felis catus@ENSFCAP00000007638[RRM1][KOG0125]Bilateria@ENSORLP00000014121[125][RRM1:100%****][FOX:75%****][KOG0125:100%****]Gammaproteobacteria@YP_113294[2][RRM1:100%][PROK:100%]
Aureococcus anophagefferens@jgi_Auran1_9354[RRM1]Dictyostelium discoideum_AX4@XP_629578[RRM1][KOG0122]
Cryptosporidium parvum_Iowa_II@XP_626081[RRM1][KOG0122]Coelomata@ENSTBEP00000011040[87][RRM1:98%****][put-sr:16%**][KOG4661:100%****]
Tribolium castaneum@XP_969134[RRM1]Tribolium castaneum@XP_971197[RRM1][KOG4661]
Embryophyta@jgi_Phypa1_1_28366[17][RRM1:100%**][put-sr:76%**][KOG0127:29%*][.KOG0125:12%][.KOG4661:6%][.KOG0147:6%]Phytophthora@jgi_Physo1_1_137237[2][RRM1:100%][put-sr:100%][KOG0125:50%][.KOG0148:50%]
Plasmodium falciparum_3D7@XP_001347313[RRM1][KOG0127]Cryptococcus neoformans_var._neoformans_JEC21@XP_570425[RRM1][put-sr][KOG0145]
Yarrowia lipolytica@XP_499712[RRM1][KOG0145]Pezizomycotina@XP_960722[3][RRM1:100%*][put-sr:33%][KOG0113:33%]Schizosaccharomyces pombe_972h-@NP_001018280[RRM1][KOG0145]
Chlamydomonas reinhardtii@jgi_Chlre3_152139[RRM1][KOG0117]Phaeodactylum tricornutum@jgi_Phatr2_16633[RRM1][KOG0125]
Desulfuromonadales@NP_952377[4][RRM1:100%*][PROK:100%*][KOG0108:50%][.KOG0145:25%]Pelobacter carbinolicus_DSM_2380@YP_357907[RRM1][PROK][KOG0145]
Oryza sativa_japonica_cultivar-group@NP_001053710[RRM1][KOG0127]rosids@30054_m000821[3][RRM1:100%*][cpRNP:33%][KOG0127:100%*]
Magnoliophyta@NP_001062760[4][RRM1:100%*][KOG0124:50%][.KOG0131:50%]Ustilago maydis_521@XP_756401[RRM1]
Magnoliophyta@NP_001058927[3][RRM1:100%*][cpRNP:33%][KOG0131:67%]Embryophyta@jgi_Phypa1_1_134646[11][RRM1:100%**][cpRNP:9%][KOG0123:45%*][.KOG0127:36%*][.KOG2029:9%]
Magnoliophyta@10511_m000028_AZM5_5258[15][RRM1:100%**][cpRNP:33%*][KOG0127:53%**][.KOG0131:27%*][.KOG0145:13%][.KOG0108:7%]Magnoliophyta@NP_001060859[5][RRM1:100%*][cpRNP:40%][KOG0110:40%][.KOG0148:40%]
Magnoliophyta@NP_001062073[4][RRM1:100%*][KOG0110:75%*][.KOG0127:25%]Trypanosoma brucei_TREU927@XP_829716[RRM1]
Clupeocephala@ENSORLP00000002364[10][RRM2:100%**][KOG0109:100%**]Endopterygota@CG7903-PA[5][RRM1:100%*][KOG0109:80%*]
Tribolium castaneum@XP_971700[RRM1]Aedes aegypti@AAEL006876-PA[RRM1][KOG2193]
Euteleostomi@ENSDNOP00000012760[63][RRM2:94%****][.RRM1:6%*][LARK:65%***][.RBM:21%**][KOG0109:97%****]Strongylocentrotus purpuratus@XP_792521[4][RRM1:100%*][put-sr:100%*][KOG0109:100%*]
Coelomata@ENSXETP00000008271[74][RRM1:100%****][LARK:61%***][KOG0109:97%****]Ciona intestinalis@ENSCINP00000017840[RRM1][KOG0109]
Ciona intestinalis@ENSCINP00000023722[RRM1][KOG0109]Ciona intestinalis@ENSCINP00000017840[RRM2][KOG0109]
Ciona@ENSCSAVP00000017501[2][RRM1:50%][.RRM2:50%][KOG0109:50%]Endopterygota@CG8597-PE[8][RRM2:100%**][LARK:62%*][KOG0109:100%**]
Danio rerio@ENSDARP00000065401[RRM2][KOG0109]Eukaryota@8925_m000027_AZM5_1178[67][RRM1:100%****][put-sr:84%****][SR:61%***][KOG4207:61%***][.KOG4368:24%**]Thalassiosira pseudonana@jgi_Thaps3_20266[RRM1][KOG4207]
Bacillariophyta@jgi_Thaps3_20223[2][RRM1:100%][KOG0108:100%]Chlamydomonadales@jgi_Chlre3_184151[2][RRM1:100%][KOG0921:50%][.KOG0116:50%]
Phaeodactylum tricornutum@jgi_Phatr2_8270[RRM1][KOG4207]Phaeodactylum tricornutum@jgi_Phatr2_49481[RRM1][KOG1337]
Aureococcus anophagefferens@jgi_Auran1_17889[RRM1][KOG4207]Theileria parva_strain_Muguga@XP_765374[RRM2]
Yarrowia lipolytica@XP_504884[RRM3][KOG0123]Aedes aegypti@AAEL010807-PA[RRM1][put-sr][KOG1080]
Euteleostomi@ENSORLP00000016244[7][RRM1:100%*][KOG1080:57%*]Pezizomycotina@XP_961985[2][RRM1:100%][KOG0116:50%]
Aureococcus anophagefferens@jgi_Auran1_69134[RRM1][put-sr]Pichia stipitis_CBS_6054@XP_001387063[RRM1]
Ashbya gossypii_ATCC_10895@NP_983970[RRM1]Candida glabrata_CBS138@XP_445637[RRM1]
Ciona intestinalis@ENSCINP00000008726[RRM1][put-sr][KOG2193]Apis mellifera@XP_393878[RRM1][put-sr][KOG2193]
Encephalitozoon cuniculi_GB-M1@NP_586226[RRM3][put-sr][KOG0123]Synechococcus@YP_473618[2][RRM1:100%][PROK:100%][KOG0108:100%]Ostreococcus@jgi_Ostta4_7793[2][RRM1:100%][KOG0108:100%]
Ciona savignyi@ENSCSAVP00000008315[4][RRM1:100%*][KOG0108:100%*]Aureococcus anophagefferens@jgi_Auran1_9018[RRM1]
Aureococcus anophagefferens@jgi_Auran1_9375[2][RRM1:100%][KOG0122:100%]Aureococcus anophagefferens@jgi_Auran1_17018[RRM1][KOG0111]Thalassiosira pseudonana@jgi_Thaps3_33709[RRM1][KOG0111]
Schizosaccharomyces pombe_972h-@NP_595090[RRM1]Saccharomycetales@YHL034C[2][RRM1:100%]
Kluyveromyces lactis@XP_453971[RRM1]Chlamydomonadales@jgi_Volca1_107658[2][RRM1:100%][KOG4205:50%][.KOG0474:50%]
Murinae@ENSMUSP00000078984[3][RRM1:100%*][KOG4207:100%*]Ostreococcus lucimarinus@jgi_Ost9901_3_8174[RRM1][KOG4207]
Tribolium castaneum@XP_970765[RRM2][KOG0127]Bacillariophyta@jgi_Thaps3_19374[2][RRM1:100%][KOG0121:100%]
Cryptosporidium parvum_Iowa_II@XP_627536[RRM1][KOG0121]Encephalitozoon cuniculi_GB-M1@NP_597585[RRM1][KOG0121]
Eukaryota@ENSMODP00000034858[66][RRM1:100%****][KOG0121:100%****]Trypanosomatidae@XP_001466901[2][RRM1:100%][KOG0121:100%]
Plasmodium falciparum_3D7@XP_001351463[RRM1][KOG0121]Theileria parva_strain_Muguga@XP_766484[RRM1][KOG0121]
Aureococcus anophagefferens@jgi_Auran1_17068[RRM1][KOG4207]Cryptosporidium parvum_Iowa_II@XP_628282[2][RRM1:100%][put-sr:100%][KOG0111:50%][.KOG4207:50%]
Plasmodium falciparum_3D7@XP_001347950[RRM1][KOG4207]Plasmodium falciparum_3D7@XP_001351591[RRM1]
Chordata@ENSETEP00000001114[45][RRM1:100%***][put-sr:96%***][SRrp:82%***][KOG0111:29%**][.KOG0415:13%*]Phytophthora@jgi_Physo1_1_136528[2][RRM1:100%][put-sr:50%][KOG3208:50%]
Chlamydomonadales@jgi_Volca1_121229[2][RRM1:100%][put-sr:100%][KOG0415:50%]Viridiplantae@NP_001046448[23][RRM1:100%***][put-sr:91%***][SR:35%**][KOG4207:13%*][.KOG0127:13%*][.KOG0110:9%]
Bacillariophyta@jgi_Thaps3_23196[2][RRM1:100%][KOG4207:50%]Phytophthora sojae@jgi_Physo1_1_138511[RRM1][put sr]
23 - SRrp
24
22 - single RRM
SR proteins
25
51 - LARK
68 - FOX
29 - dual-RRM
SR proteins
Part of 30
- hnRNP
Fig. S8
111
62
93
73
63
52
85
76
89
74
81 61
60
73
64
54
Magnoliophyta@NP 001042672[10][RRM1:100%**][oligoU:50%*][KOG4205:80%**][.KOG0149:20%]Arabidopsis thaliana@NP_850021[4][RRM1:100%*][oligoU:100%*][KOG0149:75%*][.KOG2186:25%]
Ciona intestinalis@ENSCINP00000006182[RRM1][KOG4205]Ciona intestinalis@ENSCINP00000029053[RRM1][KOG4205]
Phytophthora ramorum@jgi_Phyra1_1_73884[RRM1][KOG4205]Aureococcus anophagefferens@jgi_Auran1_6078[RRM1][KOG4205]
Strongylocentrotus purpuratus@XP_001189292[2][RRM1:100%][KOG4205:100%]Strongylocentrotus purpuratus@XP_001176409[2][RRM1:100%][KOG4205:100%]
Bilateria@ENSRNOP00000022054[326][RRM1:100%*****][hnRNP:54%*****][KOG4205:100%*****]Eukaryota@ENSMODP00000031317[289][RRM1:100%*****][hnRNP:28%****][.Musashi:13%***][.Dazap:9%***][KOG4205:99%*****]
Endopterygota@CG16901-PC[19][RRM1:100%**][KOG4205:100%**]Myotis lucifugus@ENSMLUP00000003070[RRM1][hnRNP][KOG4205]
Oryctolagus cuniculus@ENSOCUP00000001170[RRM1][hnRNP][KOG4205]Bacillariophyta@jgi_Phatr2_21039[2][RRM1:100%][KOG4205:100%]
Dictyostelium discoideum_AX4@XP_643377[RRM1][KOG3598]Plasmodium falciparum_3D7@XP_001351452[RRM2][KOG4205]
Theileria parva_strain_Muguga@XP_766400[RRM1][put-sr][KOG4205]Cryptosporidium parvum_Iowa_II@XP_626025[RRM1][KOG4205]
Strongylocentrotus purpuratus@NP_999784[3][RRM1:100%*][KOG4205:100%*]Chlamydomonadales@jgi_Chlre3_181880[2][RRM2:100%][KOG4205:100%]
Drosophila melanogaster@CG9654-PA[RRM1][KOG4205]Cryptosporidium parvum_Iowa_II@XP_001388284[RRM1][KOG4205]
Phytophthora ramorum@jgi_Phyra1_1_73884[RRM2][KOG4205]Ascomycota@XP_961230[5][RRM2:100%*][put-sr:20%][KOG4205:100%*]
Saccharomycetales@XP_449511[7][RRM2:100%*][KOG4205:100%*]Ricinus communis@28976_m000161[RRM2][KOG4205]
Thalassiosira pseudonana@jgi_Thaps3_25203[2][RRM1:100%][KOG4205:100%]Phaeodactylum tricornutum@jgi_Phatr2_41450[RRM1][KOG4205]
Dictyostelium discoideum_AX4@XP_629598[RRM2][KOG4205]Ostreococcus lucimarinus@jgi_Ost9901_3_24530[RRM1][KOG4205]
Ustilago maydis_521@XP_758567[RRM2][KOG4205]Chlamydomonadales@jgi_Volca1_107445[2][RRM2:100%][KOG4205:100%]
Physcomitrella patens@jgi_Phypa1_1_19696[RRM1][KOG4205]Caenorhabditis elegans@Y73B6BL_6b_3[10][RRM1:100%**][KOG4205:100%**]
Phaeodactylum tricornutum@jgi_Phatr2_21039[RRM2][KOG4205]Oryza sativa_japonica_cultivar-group@NP_001067093[RRM1][KOG4177]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568675[RRM2][KOG4205]Endopterygota@AAEL008257-PA[8][RRM2:100%**][KOG4205:100%**]
Viridiplantae@NP_851001[17][RRM2:100%**][put-sr:12%][KOG4205:94%**][.KOG1833:6%]Strongylocentrotus purpuratus@XP_001176409[2][RRM2:100%][KOG4205:100%]
Strongylocentrotus purpuratus@XP_001183095[2][RRM2:100%][KOG4205:100%]Caenorhabditis elegans@F42A6_7a_1[8][RRM2:100%**][KOG4205:100%**]
Coelomata@CG6354-PB[373][RRM2:95%*****][hnRNP:53%*****][KOG4205:100%*****]Drosophila melanogaster@CG9654-PA[RRM2][KOG4205]
Sorex araneus@ENSSARP00000008097[RRM2][hnRNP][KOG4205]Ciona@ENSCINP00000008394[8][RRM2:100%**][KOG4205:100%**]Ciona intestinalis@ENSCINP00000012771[RRM2][put-sr][KOG4205]
Strongylocentrotus purpuratus@NP_999784[3][RRM2:100%*][KOG4205:100%*]Plasmodium falciparum_3D7@XP_001351452[RRM1][KOG4205]
Eukaryota@AGAP006656-PA[121][RRM2:88%****][.RRM1:12%**][Musashi:36%***][.Dazap:21%***][.hnRNP:10%**][KOG4205:100%****]Cryptosporidium parvum_Iowa_II@XP_626025[RRM2][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_626579[RRM2][KOG4205]Cryptosporidium parvum_Iowa_II@XP_001388284[RRM2][KOG4205]
Ciona@ENSCSAVP00000001921[3][RRM2:100%*][Musashi:67%][KOG4205:100%*]Ciona@ENSCINP00000028810[2][RRM2:100%][KOG4205:100%]
Ciona@ENSCSAVP00000016637[3][RRM2:100%*][KOG4205:100%*]Euteleostomi@ENSDARP00000005968[129][RRM2:95%****][.RRM1:5%*][hnRNP:57%****][KOG4205:100%****]
Endopterygota@XP_001121454[19][RRM2:100%**][KOG4205:100%**]Caenorhabditis elegans@Y73B6BL_6a_3[10][RRM2:100%**][KOG4205:100%**]
Physcomitrella patens@jgi_Phypa1_1_120016[RRM2][KOG4205]Plasmodium falciparum_3D7@XP_001347758[RRM2][KOG0149]
Plasmodium falciparum_3D7@XP_001347758[RRM1][KOG0149]Encephalitozoon cuniculi_GB-M1@NP_597583[RRM2][KOG4205]
Embryophyta@jgi_Phypa1_1_112860[6][RRM2:100%*][put-sr:17%][KOG4205:100%*]Chlamydomonadales@jgi_Chlre3_105806[2][RRM2:100%][KOG4205:100%]
Chlamydomonadales@jgi_Volca1_43575[2][RRM3:100%][KOG4205:100%]Encephalitozoon cuniculi_GB-M1@NP_597487[RRM1][KOG4205]
Embryophyta@IMGA_AC144431_42_2[6][RRM3:100%*][put-sr:17%][KOG4205:100%*]Strongylocentrotus purpuratus@XP_789716[2][RRM2:100%][KOG4205:100%]
Strongylocentrotus purpuratus@XP_780859[2][RRM2:100%][KOG4205:100%]Volvox carteri@jgi_Volca1_36996[RRM1][KOG0116]
Tribolium castaneum@XP_970765[RRM1][KOG0127]Ciona intestinalis@ENSCINP00000023563[RRM1][KOG0108]Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM3][KOG0123]
Aureococcus anophagefferens@jgi_Auran1_8994[RRM1][KOG0149]Aureococcus anophagefferens@jgi_Auran1_6342[RRM2][KOG0123]
Magnoliophyta@29333_m001057[3][RRM2:67%][.RRM1:33%][cpRNP:33%][KOG0131:67%][.KOG0148:33%]Magnoliophyta@IMGA_AC119413_25_2[4][RRM2:100%*][cpRNP:25%][KOG0127:100%*]
Poaceae@19213_m000022_AZM5_85721[2][RRM1:50%][.RRM2:50%][KOG0127:50%]Arabidopsis thaliana@NP_192643[2][RRM2:100%][KOG0110:100%]
Ricinus communis@29908_m006094[RRM2][KOG0110]Magnoliophyta@NP_001048500[5][RRM2:100%*][cpRNP:20%][KOG0123:100%*]
rosids@NP_171616[3][RRM2:100%*][cpRNP:67%][KOG0148:67%][.KOG0110:33%]Oryza sativa_japonica_cultivar-group@NP_001060859[RRM2][KOG0110]
Diptera@AAEL006645-PA[2][RRM1:100%][KOG0149:100%]Diptera@AAEL008317-PA[3][RRM1:100%*][KOG0149:100%*]
Dictyostelium discoideum_AX4@XP_643856[3][RRM1:100%*][KOG0149:100%*]Strongylocentrotus purpuratus@XP_001188704[2][RRM1:100%][KOG0149:100%]
Euteleostomi@ENSSTOP00000002923[18][RRM1:100%**][KOG4205:11%]Caenorhabditis elegans@C50B8_1[RRM1]
Ustilago maydis_521@XP_761797[RRM1][put-sr][KOG3257]Yarrowia lipolytica@XP_505184[RRM1]
Ostreococcus@jgi_Ost9901_3_27365[2][RRM1:100%][KOG0123:50%]Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM2][KOG4212]
Cryptosporidium parvum_Iowa_II@XP_628165[RRM2][KOG4212]Eukaryota@jgi_Volca1_109965[18][RRM1:78%**][.RRM2:22%*][put-sr:22%*][KOG4212:61%**][.KOG0123:39%*]
Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM2][KOG0123]Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM1][put-sr][KOG0147]
Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM1][KOG4212]Volvox carteri@jgi_Volca1_103054[RRM2][KOG0055]Chlamydomonadales@jgi_Chlre3_184854[2][RRM1:100%][KOG0055:50%]
Bacillariophyta@jgi_Phatr2_7426[2][RRM1:100%]Strongylocentrotus purpuratus@XP_786244[2][RRM3:100%][put-sr:100%][KOG4212:100%]
Chordata@ENSOGAP00000002890[91][RRM3:80%****][.RRM2:13%**][.RRM1:7%*][hnRNP:37%***][KOG4212:100%****]Endopterygota@CG9373-PA[4][RRM3:100%*][KOG4212:100%*]
Strongylocentrotus purpuratus@XP_001187716[4][RRM1:100%*][put-sr:100%*][KOG4212:50%][.KOG4661:50%]Coelomata@ENSOGAP00000009767[86][RRM1:100%****][hnRNP:34%***][KOG4212:100%****]
Trypanosoma brucei_TREU927@XP_823301[RRM1][KOG0921]Theileria parva_strain_Muguga@XP_766728[RRM2][KOG0124]
Plasmodium falciparum_3D7@XP_001347332[RRM2][put-sr][KOG0105]Phytophthora ramorum@jgi_Phyra1_1_84100[RRM2][KOG0105]
Phytophthora@jgi_Physo1_1_136493[2][RRM2:100%][put-sr:100%][KOG0105:100%]Fungi/Metazoa_group@AGAP004592-PA[123][RRM2:81%****][.RRM1:18%***][put-sr:100%****][SR:60%****][KOG0105:50%****][.KOG0106:46%****]
Theileria parva_strain_Muguga@XP_766386[RRM2][put-sr][KOG0105]Bilateria@XP_967263[73][RRM2:78%****][.RRM1:22%**][put-sr:79%****][SR:75%****][KOG0105:100%****]Plasmodium falciparum_3D7@XP_001347501[RRM2][put-sr][KOG0105]
Volvox carteri@jgi_Volca1_109965[RRM2][KOG4212]Chlamydomonadales@jgi_Volca1_78979[2][RRM1:100%][KOG3070:100%]
Phaeodactylum tricornutum@jgi_Phatr2_51303[RRM2][KOG4212]Thalassiosira pseudonana@jgi_Thaps3_37126[RRM2][KOG0123] SR proteins
35 - G3BP
RBM
30K-RRM
hnRNP
Musashi
Dazap
TARDBP
OligoU
Fig. S8
112
0.20
69
57
65
76
76
91
62 66
Campylobacter@YP_001467322[2][RRM1:100%][PROK:100%][KOG0148:100%]Dictyostelium discoideum_AX4@XP_638767[RRM1][KOG0123]
cellular_organisms@YP_001113853[137][RRM1:100%****][PROK:99%****][KOG0108:58%****][.KOG0116:14%**][.KOG0921:7%**][.KOG0149:7%**][.KOG0111:6%**]Carboxydothermus hydrogenoformans_Z-2901@YP_359251[RRM1][PROK][KOG0108]
Methanomicrobiales@YP_503016[5][RRM1:100%*][PROK:100%*][KOG0108:40%][.KOG0125:20%][.KOG0116:20%]Treponema pallidum_subsp._pallidum_str._Nichols@NP_218796[RRM1][PROK][KOG0149]
Chlamydomonas reinhardtii@jgi_Chlre3_174860[RRM2][KOG1240]Gammaproteobacteria@YP_561253[27][RRM1:100%***][PROK:100%***][KOG0108:96%***]
Geobacter uraniumreducens_Rf4@YP_001230384[RRM1][PROK][KOG0108]Alkalilimnicola ehrlichei_MLHE-1@YP_741458[RRM1][PROK]
Schizosaccharomyces pombe_972h-@NP_593427[RRM1][KOG0123]Chlamydomonas reinhardtii@jgi_Chlre3_181993[RRM1]
Clupeocephala@ENSGACP00000025151[11][RRM1:100%**][KOG0109:100%**]Xenopus tropicalis@ENSXETP00000056096[RRM1][KOG0109]Mammalia@ENSTBEP00000003150[16][RRM1:100%**][RBM:94%**][KOG0109:100%**]
Syntrophobacter fumaroxidans_MPOB@YP_844222[RRM1][PROK][KOG0108]Ostreococcus@jgi_Ost9901_3_12693[2][RRM2:100%][KOG0127:100%]
Ostreococcus tauri@jgi_Ostta4_19468[RRM1][KOG0127]Bacteroidales@YP_001302325[2][RRM1:100%][PROK:100%][KOG0123:50%][.KOG0122:50%]Bacteroidales@YP_213478[13][RRM1:100%**][PROK:100%**][KOG0108:69%**][.KOG0125:31%*]Bacteroides@YP_001298723[3][RRM1:100%*][PROK:100%*][KOG0108:100%*]
Nitrosococcus oceani_ATCC_19707@YP_344746[RRM1][PROK][KOG0148]Syntrophobacter fumaroxidans_MPOB@YP_845575[RRM1][PROK]
Candidatus Protochlamydia_amoebophila_UWE25@YP_007892[RRM1][PROK][KOG0149]Leptospira@YP_000459[4][RRM1:100%*][PROK:100%*][KOG0108:100%*]
Gammaproteobacteria@YP_001083500[11][RRM1:100%**][PROK:100%**][KOG0145:27%*][.KOG0108:18%][.KOG0144:9%][.KOG0122:9%]Vibrio fischeri_ES114@YP_206444[RRM1][PROK][KOG0145]
Ustilago maydis_521@XP_761797[RRM2][put-sr][KOG3257]Schizosaccharomyces pombe_972h-@NP_593531[RRM1][nucleolin][KOG0147]Yarrowia lipolytica@XP_505375[RRM1][KOG0148]
Saccharomycetales@XP_456900[6][RRM1:100%*][nucleolin:17%][KOG0148:50%*][.KOG0131:33%][.KOG4210:17%]Basidiomycota@XP_566835[2][RRM1:100%][KOG0148:100%]
Neurospora crassa_OR74A@XP_963862[RRM1][KOG0127]Aspergillus fumigatus_Af293@XP_754840[RRM1][KOG0148]
Phytophthora@jgi_Phyra1_1_75647[2][RRM1:100%]Magnoliophyta@NP_566958[6][RRM2:67%*][.RRM1:33%][KOG0123:33%][.KOG0124:33%][.KOG0131:33%]
Ostreococcus@jgi_Ost9901_3_34381[2][RRM1:100%][KOG0145:100%]Cyanobacteria@YP_476186[8][RRM1:100%**][PROK:100%**][KOG0108:38%*][.KOG0122:12%]
Cyanobacteria@NP_898344[17][RRM1:100%**][PROK:100%**][KOG0108:65%**]Synechococcus_elongatus@YP_399809[2][RRM1:100%][PROK:100%][KOG0108:100%]
Leishmania infantum_JPCM5@XP_001467067[2][RRM1:100%][KOG0144:100%]Dictyostelium discoideum_AX4@XP_638767[RRM2][KOG0123]
Pezizomycotina@XP_961985[2][RRM2:100%][KOG0116:50%]Schizosaccharomyces pombe_972h-@NP_595090[RRM2]
Eukaryota@XP_391240[27][RRM2:67%**][.RRM1:33%**][cpRNP:19%*][KOG0127:48%**][.KOG0108:22%*][.KOG0131:15%*][.KOG0149:7%][.KOG0145:7%]Oryza sativa_japonica_cultivar-group@NP_001045556[RRM1][KOG0108]
Magnoliophyta@NP_181287[9][RRM1:100%**][oligoU:22%][KOG0148:56%*][.KOG0127:22%][.KOG0145:11%][.KOG0113:11%]Magnoliophyta@29930_m000611[5][RRM1:100%*][KOG0113:100%*]
Magnoliophyta@9946_m000021_AZM5_3995[2][RRM1:100%][KOG0111:50%][.KOG0113:50%]rosids@29154_m000213[5][RRM1:100%*][oligoU:40%][KOG0122:40%][.KOG0113:20%][.KOG0148:20%]
Magnoliophyta@NP_001052753[3][RRM1:100%*][oligoU:33%][KOG0108:33%][.KOG0149:33%][.KOG0127:33%]Medicago truncatula@IMGA_AC122162_7_2[RRM1][KOG0149]Ricinus communis@30055_m001598[RRM1][KOG0149]
Arabidopsis thaliana@NP_565646[RRM1][KOG0149]Eukaryota@jgi_Phypa1_1_37849[169][RRM1:100%*****][put-sr:5%**][GRSRBP:33%****][.hnRNP:18%***][.RBMY:15%***][KOG0108:23%***][.KOG0111:23%***][.KOG0149:18%***][.KOG0117:11%**][.KOG0116:9%**]
Euteleostomi@ENSGALP00000012472[36][RRM4:89%***][.RRM2:8%*][nucleolin:56%**][KOG0123:100%***]Yarrowia lipolytica@XP_500351[RRM2][KOG0123]
Arabidopsis thaliana@NP_173298[RRM1][GRSRBP][KOG0149]Magnoliophyta@NP_001059075[6][RRM1:100%*][put-sr:17%][GRSRBP:50%*][KOG0108:50%*][.KOG0148:33%][.KOG0111:17%]
Physcomitrella patens@jgi_Phypa1_1_151460[4][RRM1:100%*][KOG0108:75%*][.KOG0149:25%]rosids@NP_568388[3][RRM1:100%*][KOG0125:33%][.KOG0148:33%]
Oryza sativa_japonica_cultivar-group@NP_001054954[2][RRM1:100%][KOG0108:100%]Phytophthora@jgi_Phyra1_1_84416[2][RRM1:100%][KOG0148:100%]
Arabidopsis thaliana@NP_179762[RRM1][oligoU]Phytophthora@jgi_Physo1_1_134615[2][RRM1:100%]
Aureococcus anophagefferens@jgi_Auran1_66158[RRM2][put-sr][KOG0149]Ciona@ENSCINP00000012771[9][RRM1:100%**][put-sr:11%][KOG4205:100%**]
Ricinus communis@28976_m000161[RRM1][KOG4205]Ricinus communis@30170_m013671[RRM1][KOG4205]
Arabidopsis thaliana@NP_176143[RRM1][KOG4205]Zea mays@14684_m000016_AZM5_14964[RRM1][KOG4205]
Oryza sativa_japonica_cultivar-group@NP_001058805[RRM1][KOG4205]Oryza sativa_japonica_cultivar-group@NP_001051402[RRM1][KOG0149]
Aureococcus anophagefferens@jgi_Auran1_9576[RRM1][KOG0149]Cyanidioschyzon merolae@gnl_CMER_CMR392C[RRM1][KOG4205]
Chlamydomonadales@jgi_Volca1_107445[2][RRM1:100%][KOG4205:100%]Embryophyta@jgi_Phypa1_1_156290[6][RRM1:100%*][put-sr:17%][KOG4205:100%*]
Chlamydomonadales@jgi_Chlre3_105806[2][RRM1:100%][KOG4205:100%]Strongylocentrotus purpuratus@XP_789716[2][RRM1:100%][KOG4205:100%]
Coelomata@SINFRUP00000146060[58][RRM1:100%****][TARDBP:72%***][KOG4205:98%****]Ostreococcus tauri@jgi_Ostta4_33731[RRM1]
Ostreococcus tauri@jgi_Ostta4_33731[RRM2]Cyanidioschyzon merolae@gnl_CMER_CMR392C[RRM2][KOG4205]
Cryptosporidium parvum_Iowa_II@XP_628599[RRM1][KOG4205]Plasmodium falciparum_3D7@XP_001352039[RRM1][KOG0144]
Cryptosporidium parvum_Iowa_II@XP_626158[RRM2][KOG0144]Plasmodium falciparum_3D7@XP_001352039[RRM2][KOG0144]
Cryptosporidium parvum_Iowa_II@XP_628599[RRM2][KOG4205]Takifugu rubripes@SINFRUP00000163373[RRM1][KOG0149]
Takifugu rubripes@SINFRUP00000145256[RRM1][KOG0149]Arabidopsis thaliana@NP_187353[RRM1][30kRRM][KOG0149]
Arabidopsis thaliana@NP_200183[2][RRM1:100%][oligoU:100%][KOG0149:100%]Eukaryota@NP_001058102[93][RRM1:100%****][RBM:52%***][.30kRRM:13%**][KOG0149:96%****]
Phytophthora sojae@jgi_Physo1_1_139371[RRM2][KOG4205]Phytophthora sojae@jgi_Physo1_1_139371[RRM1][KOG4205]
Oryza sativa_japonica_cultivar-group@NP_001054022[RRM1][KOG4205]Magnoliophyta@NP_001042672[10][RRM1:100% ][oligoU:50% ][KOG4205:80% ][.KOG0149:20%]
58 - GSRBP
hnRNP
RBMY
50 - LARK
88 - prokaryotic RRMS
Fig. S8
113
56
80
60
83
74
72
73
55
Diptera@PRO AAEL008317 PA[8][RRM1:100%**][KOG0149:100%**]Basidiomycota@PRO_XP_568669[11][RRM1:100%**][KOG0127:100%**]
Euteleostomi@PRO_ENSOANP00000001262[52][RRM1:100%***][RBM:54%***][KOG0127:100%***]Pezizomycotina@REF_XP_661934[24][RRM1:100%***][put-sr:12%*][KOG0127:100%***]
Saccharomycetales@REF_XP_710417[26][RRM1:100%***][KOG0127:100%***]Schizosaccharomyces_pombe@PRO_NP_596114[3][RRM1:100%*][KOG0127:100%*]
Phytophthora@PRO_jgi_Physo1_1_132702[3][RRM1:100%*][KOG0127:100%*]Chlamydomonadales@PRO_jgi_Chlre3_186870[2][RRM1:100%][KOG0127:100%]
Nematostella vectensis@REF_XP_001631286[RRM1][KOG0127]Dictyostelium discoideum_AX4@PRO_XP_646584[3][RRM1:100%*][KOG0127:100%*]
Physcomitrella patens@PRO_jgi_Phypa1_1_201182[RRM1][KOG0127]Magnoliophyta@PRO_NP_565513[12][RRM1:100%**][KOG0127:100%**]
Ciona@PRO_ENSCINP00000018772[3][RRM1:100%*][KOG0127:100%*]Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_26255[2][RRM1:100%][KOG0127:100%]
Ostreococcus tauri@PRO_jgi_Ostta4_19569[RRM1][KOG0127]Trichomonas vaginalis_G3@REF_XP_001319505[RRM2]
Strongylocentrotus purpuratus@PRO_XP_001198098[4][RRM1:100%*][put-sr:100%*][KOG0147:100%*]Dictyostelium discoideum_AX4@SMA_Q54QQ7_DICDI[3][RRM1:100%*][KOG0147:100%*]Phytophthora@PRO_jgi_Physo1_1_157186[2][RRM1:100%][KOG0147:100%]Eukaryota@REF_NP_060577[180][RRM1:100%*****][put-sr:93%*****][UMH:38%****][.CAPER:22%***][KOG0147:100%*****]
Yarrowia lipolytica@PRO_XP_504318[3][RRM1:100%*][KOG0147:100%*]Ostreococcus@PRO_jgi_Ost9901_3_42846[3][RRM1:100%*][put-sr:67%][KOG0147:100%*]
Volvox carteri@PRO_jgi_Volca1_84128[2][RRM1:100%][put-sr:50%][KOG0147:100%]Apicomplexa@REF_XP_666635[20][RRM1:100%**][put-sr:25%*][KOG0147:100%**]
Cyanidioschyzon merolae@PRO_gnl_CMER_CMT598C[RRM1][KOG0148]Saccharomycetales@REF_XP_001524014[3][RRM1:100%*]
Yarrowia lipolytica@SMA_Q6C0L4_YARLI[RRM1][put-sr]Saccharomycetales@PRO_XP_454821[11][RRM1:100%**][KOG3598:45%*][.KOG1984:27%*]
Trichocomaceae@REF_XP_001270976[2][RRM1:100%][put-sr:100%][KOG0107:50%]Giardia lamblia_ATCC_50803@REF_XP_001708899[2][RRM1:100%][KOG0131:100%]Saccharomycetales@REF_XP_001525882[11][RRM1:100%**][KOG0131:100%**]
Trypanosoma@SMA_Q4DAT0_TRYCR[2][RRM1:100%][KOG0131:100%]Cryptosporidium@PRO_XP_627780[4][RRM1:100%*][KOG0131:100%*]
Danio rerio@REF_XP_694258[RRM1][KOG4454]Eumetazoa@REF_NP_001084686[104][RRM1:100%****][KOG4454:62%****][.KOG0131:38%***]
Sophophora@PRO_CG11454-PA[5][RRM1:100%*][KOG4454:100%*]Endopterygota@SMA_ENSANGP00000021860[12][RRM1:100%**][KOG4454:58%*][.KOG0131:42%*]
Dictyostelium discoideum_AX4@PRO_XP_647248[3][RRM1:100%*][KOG0131:100%*]Bigelowiella natans@SMA_Q3LWM7_CHLS6[RRM1][KOG0131]
Caenorhabditis@REF_XP_001664456[6][RRM1:100%*][KOG4454:100%*]Entamoeba histolytica_HM-1_IMSS@REF_XP_655332[2][RRM1:100%][KOG0131:100%]
Magnoliophyta@SMA_Q75HQ8_ORYSA[12][RRM1:100%**][put-sr:8%][KOG0131:92%**][.KOG2288:8%]Tetraodon nigroviridis@SMA_Q4SJ30_TETNG[RRM1][KOG0131]
Eukaryota@PRO_NP_001064759[182][RRM1:100%*****][snRNP:5%**][KOG0131:100%*****]Kluyveromyces lactis@SMA_Q6CT95_KLULA[RRM1][KOG0131]
Saccharomycetales@SMA_Q75E82_ASHGO[6][RRM1:100%*][KOG0131:100%*]Saccharomycetaceae@SMA_HSH49_YEAST[4][RRM1:100%*][KOG0131:100%*]
Phytophthora@PRO_jgi_Physo1_1_132702[3][RRM3:100%*][KOG0127:100%*]Schizosaccharomyces_pombe@PRO_NP_001018280[3][RRM1:100%*][KOG0145:100%*]
Arabidopsis thaliana@PRO_NP_974808[5][RRM1:100%*][KOG0123:60%*][.KOG0148:40%]Ustilago maydis_521@PRO_XP_758439[3][RRM3:67%][.RRM2:33%][KOG0123:100%*]
Oryza sativa_japonica_cultivar-group@SMA_Q5F1W8_ORYSA[2][RRM1:100%][put-sr:100%][KOG0147:100%]Chlamydomonas reinhardtii@PRO_jgi_Chlre3_152139[RRM1][KOG0117]
Basidiomycota@PRO_XP_757472[13][RRM1:100%**][put-sr:23%*][KOG0122:38%*]Anopheles gambiae_str._PEST@SMA_Q7QFZ7_ANOGA[RRM2][KOG0145]
Caenorhabditis@PRO_C18D11_4_1[6][RRM1:100%*][put-sr:100%*][KOG0921:67%*][.KOG0122:33%]Encephalitozoon_cuniculi@PRO_NP_585779[3][RRM1:100%*]
Dictyostelium discoideum_AX4@PRO_XP_642304[3][RRM1:100%*][KOG0415:100%*]Anopheles_gambiae@SMA_ENSANGP00000010299[2][RRM1:100%][put-sr:100%]
Aedes aegypti@PRO_AAEL004293-PA[2][RRM1:100%][put-sr:100%]Schistosoma japonicum@SMA_Q5D9L3_SCHJA[RRM1][put-sr]
Pan troglodytes@REF_XP_001157764[RRM1][put-sr]Eutheria@PRO_ENSMLUP00000005283[2][RRM1:100%][put-sr:100%]Spermophilus tridecemlineatus@PRO_ENSSTOP00000006011[RRM1][put-sr]
Entamoeba histolytica_HM-1_IMSS@REF_XP_655465[2][RRM1:100%][put-sr:100%][KOG0145:100%]Ustilago maydis_521@SMA_Q4PBP3_USTMA[RRM1][put-sr]Cryptococcus_neoformans_var._neoformans@SMA_Q55TK9_CRYNE
Yarrowia lipolytica@PRO_XP_499712[3][RRM1:100%*][KOG0145:100%*]Pezizomycotina@PRO_XP_960722[24][RRM1:100%***][put-sr:38%**][KOG0116:17%*][.KOG0113:12%*]
Embryophyta@PRO_jgi_Phypa1_1_28366[34][RRM1:100%***][put-sr:82%***][KOG0127:26%**][.KOG4661:6%][.KOG0125:6%]Tribolium castaneum@PRO_XP_969134[3][RRM1:100%*]
Tribolium castaneum@PRO_XP_971197[3][RRM1:100%*][KOG4661:100%*]Eumetazoa@PRO_ENSTBEP00000011040[221][RRM1:98%*****][put-sr:11%***][KOG4661:100%*****]
Caenorhabditis briggsae@SMA_Q61WJ8_CAEBR[RRM1][put-sr]Dictyostelium discoideum_AX4@SMA_Q54CU2_DICDI[3][RRM1:100%*][KOG0122:100%*]
Pan troglodytes@SMA_UPI0000493D8A[RRM1][KOG0125]Caenorhabditis@PRO_ZC404_8_2[6][RRM1:100%*][KOG0125:100%*]
Eumetazoa@SMA_ENSPTRP00000024635[311][RRM1:100%*****][FOX:80%*****][KOG0125:100%*****]Felis catus@PRO_ENSFCAP00000007638[RRM1][KOG0125]
Phytophthora@PRO_jgi_Physo1_1_137237[2][RRM1:100%][put-sr:100%][KOG0125:50%][.KOG0148:50%]Plasmodium@PRO_XP_001347313[6][RRM1:100%*][KOG0127:100%*]
Entamoeba histolytica_HM-1_IMSS@REF_XP_650669[2][RRM2:100%][KOG0145:100%]Paramecium tetraurelia@REF_XP_001457311[RRM1][put-sr][KOG4207]
Tetrahymena thermophila_SB210@REF_XP_001021930[2][RRM1:100%][put-sr:100%]Tetrahymena thermophila_SB210@SMA_Q23YX0_TETTH[2][RRM2:100%][put-sr:100%]
68 - FOX
46
47
46
49
75 - CAPER
UMH
70 - RBM
Fig. S9
114
62
74
94
53
87
68
93
76
55
65
76
78
Arabidopsis thaliana@SMA Q9FFR1 ARATH[29][RRM1:38%**][ RRM2:34%**][ RRM4:14%*][ RRM3:14%*][PABP:28%**][KOG0123:100%***]Arabidopsis thaliana@SMA_Q9M300_ARATH[RRM1][KOG2159]
Sclerotiniaceae@REF_XP_001593549[2][RRM3:50%][.RRM2:50%][KOG0128:100%]Magnaporthe grisea_70-15@REF_XP_362282[2][RRM3:50%][.RRM2:50%][KOG0123:100%]
Ophiostoma ulmi@SMA_Q01491_OPHUL[RRM3][KOG0128]Sordariales@PRO_XP_958552[5][RRM3:100%*][KOG0128:60%*][.KOG0117:40%]
Trichomonas vaginalis_G3@REF_XP_001326638[RRM1]Caenorhabditis@REF_XP_001670277[6][RRM2:100%*][KOG0128:100%*]
Physcomitrella patens@PRO_jgi_Phypa1_1_201182[RRM3][KOG0127]Magnoliophyta@PRO_NP_001051595[12][RRM3:92%**][.RRM2:8%][KOG0127:100%**]
Dictyostelium discoideum_AX4@PRO_XP_646584[3][RRM3:100%*][KOG0127:100%*]Chlamydomonadales@PRO_jgi_Volca1_87629[2][RRM3:100%][KOG0127:100%]
Ostreococcus@PRO_jgi_Ostta4_19569[3][RRM3:100%*][KOG0127:100%*]Nematostella vectensis@REF_XP_001631286[RRM3][KOG0127]
Ciona intestinalis@PRO_ENSCINP00000018774[2][RRM3:100%][KOG0127:100%]Caenorhabditis@PRO_R05H10_2[4][RRM2:100%*][KOG0127:100%*]
Euteleostomi@PRO_ENSGACP00000016696[46][RRM3:80%***][.RRM1:11%*][.RRM4:9%*][RBM:65%***][KOG0127:100%***]Saccharomycetales@REF_XP_001642245[26][RRM3:96%***][KOG0127:100%***]Pezizomycotina@SMA_Q2H6T1_CHAGB[23][RRM3:100%***][put-sr:13%*][KOG0127:100%***]
Basidiomycota@SMA_Q4PH97_USTMA[11][RRM4:55%*][.RRM3:45%*][KOG0127:100%**]Schizosaccharomyces_pombe@SMA_O74400_SCHPO[3][RRM3:100%*][KOG0127:100%*]
Strongylocentrotus purpuratus@SMA_UPI0000584CE1[5][RRM2:80%*][.RRM1:20%][KOG0127:100%*]Endopterygota@PRO_XP_001605703[8][RRM2:75%*][.RRM3:25%][KOG0127:100%**]
Sophophora@SMA_Q293A7_DROPS[5][RRM2:100%*][KOG0127:100%*]Culicidae@SMA_ENSANGP00000021189[3][RRM2:67%][.RRM1:33%][KOG0127:100%*]
Schizosaccharomyces_pombe@PRO_NP_596518[3][RRM1:100%*][KOG0116:100%*]Filobasidiella_neoformans@PRO_XP_572946[5][RRM1:100%*][KOG0108:100%*]
Poaceae@PRO_NP_001058465[4][RRM1:100%*][KOG0108:100%*]Aureococcus anophagefferens@PRO_jgi_Auran1_23269[RRM1][KOG0108]
Bacillariophyta@PRO_jgi_Phatr2_8451[2][RRM1:100%][KOG0108:100%]Plasmodium@REF_XP_001608355[10][RRM1:100%**][KOG0108:100%**]Cryptosporidium_parvum@PRO_XP_627975[3][RRM1:100%*][KOG0108:100%*]
Pan troglodytes@SMA_ENSPTRP00000041315[RRM1][KOG0108]Eukaryota@PRO_ENSDARP00000064611[234][RRM1:100%*****][KOG0108:98%*****]
Ostreococcus tauri@PRO_jgi_Ostta4_31925[RRM1][KOG0117]Microsporidia@SMA_Q6E6D6_ANTLO[4][RRM1:100%*][KOG0108:100%*]
Viridiplantae@SMA_O80743_ARATH[5][RRM1:100%*][put-sr:20%][KOG2253:60%*][.KOG0108:40%]Cryptosporidium@SMA_Q5CGW1_CRYHO[2][RRM1:100%]Bilateria@SMA_Q22859_CAEEL[44][RRM1:100%***][put-sr:80%***][RBM:70%***][KOG2253:98%***]
Paramecium tetraurelia@REF_XP_001425767[RRM1][KOG2253]Cryptosporidium@PRO_XP_628165[4][RRM2:100%*][KOG4212:100%*]
Yarrowia lipolytica@SMA_Q6C133_YARLI[RRM1]Trichomonas vaginalis_G3@REF_XP_001315389[RRM1]
Dikarya@PRO_NP_596771[7][RRM1:100%*][KOG0108:57%*]Trichomonas vaginalis_G3@REF_XP_001300735[2][RRM1:100%]
Pezizomycotina@REF_XP_001242919[19][RRM1:100%**][put-sr:26%*][KOG0533:89%**][.KOG0122:5%][.KOG0517:5%]Dictyostelium discoideum_AX4@PRO_XP_638266[3][RRM1:100%*][KOG0533:100%*]
Yarrowia lipolytica@PRO_XP_505140[3][RRM1:100%*][KOG0533:100%*]Ustilago maydis_521@PRO_XP_757147[3][RRM1:100%*][KOG0533:100%*]
Theileria@PRO_XP_764636[5][RRM1:100%*][KOG0533:40%]Plasmodium@PRO_XP_966143[6][RRM1:100%*][KOG0533:50%*]
Chlamydomonadales@PRO_jgi_Volca1_90392[2][RRM1:100%][KOG0533:100%]Schizosaccharomyces pombe@SMA_YBLC_SCHPO[RRM1][KOG0533]
Eukaryota@PRO_GSTENP00007343001[207][RRM1:99%*****][FCAFPA:9%**][KOG0533:99%*****]Ostreococcus tauri@PRO_jgi_Ostta4_36431[RRM1][KOG0533]
Drosophila melanogaster@SMA_Q9VK76_DROME[RRM1][KOG0533]Phytophthora@PRO_jgi_Phyra1_1_97175[2][RRM1:100%][put-sr:50%][KOG0533:100%]
Cyanidioschyzon merolae@PRO_gnl_CMER_CMH135C[RRM1]Euteleostomi@PRO_ENSTBEP00000009485[20][RRM1:100%**][PDIP:75%**][KOG0533:60%**]
Strongylocentrotus purpuratus@SMA_UPI000058710F[RRM1]Endopterygota@PRO_CG6961-PA[19][RRM1:100%**][KOG0533:26%*]
Ustilago maydis_521@SMA_Q4P7M8_USTMA[3][RRM1:100%*][KOG0533:100%*]Filobasidiella_neoformans@PRO_XP_572037[4][RRM1:100%*][KOG0533:100%*]
Schizosaccharomyces_pombe@PRO_NP_595715[3][RRM1:100%*][KOG0533:100%*]Sordariomycetes@REF_XP_370171[11][RRM1:100%**][KOG0533:100%**]
Eurotiomycetidae@REF_XP_001259289[6][RRM1:100%*][KOG0533:100%*]Saccharomycetales@PRO_XP_462132[14][RRM1:100%**][KOG0533:100%**]
Leishmania@REF_XP_001682242[5][RRM1:100%*][KOG0113:100%*]Trypanosoma@SMA_Q4D8I9_TRYCR[2][RRM1:100%][KOG0113:100%]
Trichomonas vaginalis_G3@REF_XP_001319130[RRM1]Trichomonas vaginalis_G3@REF_XP_001330225[RRM1]
Phytophthora ramorum@PRO_jgi_Phyra1_1_94226[RRM1][put-sr][KOG0941]Eukaryota@PRO_NP_001063859[81][RRM1:100%****][ZCRB1:69%****][KOG0108:52%***][.KOG0122:10%**][.KOG0117:9%*]
Culicidae@SMA_ENSANGP00000028861[4][RRM1:100%*][KOG0108:50%][.KOG0117:50%]Chlamydomonas reinhardtii@PRO_jgi_Chlre3_120019[RRM2][KOG0106]
Chlamydomonas reinhardtii@PRO_jgi_Chlre3_80366[RRM2][KOG0106]Embryophyta@PRO_29742_m001371[30][RRM2:87%***][.RRM1:13%*][put-sr:93%***][SR:77%***][KOG0106:100%***]
Bacillariophyta@PRO_jgi_Phatr2_47737[2][RRM1:100%][put-sr:50%]Cyanidioschyzon merolae@PRO_gnl_CMER_CMO009C[RRM2]
Dictyostelium discoideum_AX4@PRO_XP_628876[3][RRM1:100%*]Bacillariophyta@PRO_jgi_Thaps3_19374[2][RRM1:100%][KOG0121:100%]
Entamoeba histolytica_HM-1_IMSS@REF_XP_652915[2][RRM1:100%][KOG0121:100%]Trichomonas vaginalis_G3@REF_XP_001315386[RRM1][KOG0121]
Encephalitozoon_cuniculi@PRO_NP_597585[3][RRM1:100%*][KOG0121:100%*]Cryptosporidium@REF_XP_666381[5][RRM1:100%*][KOG0121:100%*]
Paramecium tetraurelia@REF_XP_001451996[2][RRM1:100%][KOG0121:100%]Eukaryota@SMA_UPI00004950A8[177][RRM1:100%*****][KOG0121:100%*****]
Chaetomium globosum_CBS_148.51@SMA_Q2H8U9_CHAGB[RRM1][KOG0121]Tetrahymena thermophila_SB210@SMA_Q22J29_TETTH[2][RRM1:100%][KOG0121:100%]Plasmodium@REF_XP_001615036[8][RRM1:100%**][KOG0121:100%**]
Piroplasmida@SMA_Q8IS02_BABBO[7][RRM1:100%*][KOG0121:100%*]Piroplasmida@REF_XP_953469[5][RRM1:100%*][KOG0117:40%]
Caenorhabditis@PRO_R09B3_3[15][RRM1:100%**][KOG0108:100%**]Brugia malayi@SMA_P90699_BRUMA[RRM1][KOG0108]
Entamoeba histolytica_HM-1_IMSS@REF_XP_648980[3][RRM1:100%*][KOG0123:100%*]Entamoeba histolytica_HM-1_IMSS@REF_XP_654358[3][RRM2:100%*][KOG0123:100%*]
Trichomonas vaginalis_G3@REF_XP_001297747[RRM2][KOG0123]Trichomonas vaginalis_G3@REF_XP_001294506[RRM2][KOG0123]Dikarya@SMA_Q5KLL0_CRYNE[8][RRM2:100%**][KOG0117:38%*]
Nematostella vectensis@REF_XP_001632599[RRM1][KOG0127]Caenorhabditis@REF_XP_001679781[6][RRM1:100%*]
Nematostella vectensis@REF_XP_001635220[RRM1]Trichomonas vaginalis_G3@REF_XP_001305703[RRM3][KOG0123]
Trichomonas vaginalis_G3@REF_XP_001319505[RRM1]Plasmodium@REF_XP_676651[9][RRM1:100%**][KOG0144:100%**]Cryptosporidium@PRO_XP_628599[5][RRM1:100%*][KOG4205:100%*]
Nematostella vectensis@REF_XP_001637248[RRM1]Coelomata@PRO_AAEL001684-PA[87][RRM1:100%****][KOG0125:26%***]Euteleostomi@PRO_ENSEEUP00000005436[162][RRM1:92%*****][.RRM2:6%**]
Takifugu rubripes@PRO_SINFRUP00000155469[2][RRM1:100%]Spermophilus tridecemlineatus@PRO_ENSSTOP00000003171[RRM1]Tupaia belangeri@PRO_ENSTBEP00000015084[RRM1]
Tetrahymena thermophila_SB210@REF_XP_001026299[2][RRM1:100%]Paramecium tetraurelia@REF_XP_001428916[RRM1]
Dictyostelium_discoideum@SMA_Q86I71_DICDI[9][RRM1:100%**][KOG0149:100%**]Nematostella vectensis@REF_XP_001628811[RRM1][KOG0149]Euteleostomi@PRO_ENSSTOP00000002923[42][RRM1:100%***][KOG4205:14%*]
Strongylocentrotus purpuratus@PRO_XP_001188704[4][RRM1:100%*][KOG0149:100%*]Diptera@SMA_Q7PX54_ANOGA[8][RRM1:100%**][KOG0149:100%**]
Diptera@PRO_AAEL008317-PA[8][RRM1:100%**][KOG0149:100%**]
24
56 - green plant-specific
RS group of SR proteins
57 - ZCRB1
part of 30 - hnRNP
PDIP
FCA FPA
72 - RBM
Fig. S9
115
80
59
92
50
53
60 71
62
Anopheles gambiae@PRO AGAP000525 PA[4][RRM1:100%*]Drosophila melanogaster@PRO_CG10837-PA[7][RRM1:100%*]
Entamoeba histolytica_HM-1_IMSS@SMA_Q50YJ3_ENTHI[RRM1]Entamoeba histolytica_HM-1_IMSS@REF_XP_657381[2][RRM1:100%]
Paramecium tetraurelia@REF_XP_001435565[2][RRM2:100%][KOG0123:50%][.KOG0147:50%]Chlamydomonadales@PRO_jgi_Volca1_54847[2][RRM1:100%][KOG0108:100%]
Tetrahymena_thermophila@REF_XP_001019282[5][RRM2:60%*][.RRM3:40%][KOG4205:60%*][.KOG0123:40%]Physcomitrella patens@PRO_jgi_Phypa1_1_167900[3][RRM1:100%*][KOG0123:33%][.KOG4210:33%][.KOG1015:33%]
Ostreococcus tauri@PRO_jgi_Ostta4_10328[RRM1][KOG2476]Magnoliophyta@SMA_Q41042_PEA[16][RRM1:100%**][nucleolin:38%*][KOG0123:44%*][.KOG4210:38%*][.KOG1015:12%][.KOG0148:6%]
Entamoeba histolytica_HM-1_IMSS@REF_XP_655048[2][RRM1:100%][put-sr:100%][KOG0123:100%]Phaeodactylum tricornutum@PRO_jgi_Phatr2_49387[RRM1]
Aureococcus anophagefferens@PRO_jgi_Auran1_9434[RRM1]Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_92667[2][RRM1:100%]
Embryophyta@PRO_28180_m000395[12][RRM2:100%**][KOG4205:50%*][.KOG0124:42%*][.KOG4211:8%]Phytophthora@PRO_jgi_Physo1_1_141766[2][RRM2:100%][KOG0148:100%]
stramenopiles@PRO_jgi_Auran1_17857[4][RRM1:50%][.RRM2:50%][KOG0108:50%][.KOG4205:50%]Aureococcus anophagefferens@PRO_jgi_Auran1_64341[RRM2][KOG0108]
Ostreococcus tauri@PRO_jgi_Ostta4_32569[RRM2]Strongylocentrotus purpuratus@PRO_XP_001180991[8][RRM1:100%**]
Nematostella vectensis@REF_XP_001630508[RRM1][KOG1015]Ostreococcus@PRO_jgi_Ost9901_3_31221[3][RRM1:100%*][KOG0128:100%*]
Magnoliophyta@PRO_29609_m000574[10][RRM1:100%**][KOG0128:100%**]Physcomitrella patens@PRO_jgi_Phypa1_1_135986[RRM1][KOG0128]Ascomycota@PRO_NP_595728[23][RRM1:100%***][put-sr:13%*]
Ustilago maydis_521@PRO_XP_762237[3][RRM1:100%*]Schistosoma japonicum@SMA_Q5D9X4_SCHJA[RRM1]
Ostreococcus@PRO_jgi_Ostta4_33150[3][RRM2:100%*][KOG0108:33%]Trichomonas vaginalis_G3@REF_XP_001317333[RRM2]
Nematostella vectensis@REF_XP_001636038[RRM2][KOG1874]Chordata@PRO_ENSETEP00000010530[72][RRM1:64%***][.RRM2:36%***][put-sr:97%****][SRrp:72%***][KOG4676:100%****]
Caenorhabditis@SMA_RSP7_CAEEL[2][RRM1:100%][put-sr:100%][SR:100%][KOG4676:100%]Culicidae@PRO_AAEL011961-PA[7][RRM1:100%*][KOG0128:100%*]
Tetrahymena thermophila_SB210@REF_XP_001015927[2][RRM2:100%][KOG0128:100%]Apocrita@PRO_XP_001602582[7][RRM1:100%*][KOG0128:100%*]
Caenorhabditis@SMA_Q17430_CAEEL[2][RRM1:100%][KOG0128:100%]Ciona intestinalis@PRO_ENSCINP00000019832[3][RRM1:100%*][KOG0128:100%*]
Nematostella vectensis@REF_XP_001629405[RRM1][KOG0128]Tribolium castaneum@PRO_XP_972538[2][RRM1:100%][KOG0128:100%]
Euteleostomi@PRO_ENSSTOP00000002132[65][RRM1:100%****][SART3:74%***][KOG0128:100%****]Strongylocentrotus purpuratus@PRO_XP_781643[3][RRM1:100%*][KOG0128:100%*]
Strongylocentrotus purpuratus@REF_XP_001198948[RRM1]Cyanidioschyzon merolae@PRO_gnl_CMER_CMO334C[RRM2][KOG0126]
Caenorhabditis@PRO_F11A10_7[5][RRM2:100%*][KOG0131:60%*]Magnoliophyta@PRO_30054_m000807[5][RRM2:100%*][KOG1267:20%]Ostreococcus@PRO_jgi_Ostta4_30189[3][RRM1:67%][.RRM2:33%][put-sr:67%]
Volvox carteri@PRO_jgi_Volca1_118759[RRM2]Filobasidiella neoformans@SMA_Q5KL47_CRYNE[RRM1]
Dictyostelium discoideum_AX4@SMA_Q54GS2_DICDI[3][RRM2:100%*]Trypanosomatidae@PRO_XP_827554[12][RRM2:83%**][.RRM1:17%][put-sr:33%*][KOG0108:33%*]
Apis mellifera@PRO_XP_394565[3][RRM2:100%*][KOG0147:100%*]Eumetazoa@REF_XP_001630180[62][RRM2:87%***][.RRM1:13%**][KOG0108:16%**][.KOG0126:6%*][.KOG3001:5%*][.KOG0123:5%*]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_46145[RRM2]Strongylocentrotus purpuratus@SMA_UPI0000587A00[RRM2][KOG0147]
Tetrahymena thermophila_SB210@REF_XP_001031760[2][RRM2:100%]Paramecium tetraurelia@REF_XP_001427059[RRM2]
Ascomycota@PRO_XP_505055[21][RRM1:86%**][.RRM2:14%*]Drosophila melanogaster@PRO_CG12288-PA[3][RRM2:100%*]
Trypanosomatidae@REF_XP_001566882[11][RRM1:100%**][KOG4209:100%**]Tetrahymena thermophila_SB210@REF_XP_001018896[2][RRM1:100%][KOG4209:100%]
Paramecium tetraurelia@REF_XP_001433584[2][RRM1:100%][KOG4209:100%]Aedes aegypti@PRO_AAEL012119-PA[2][RRM1:100%]
Ciona intestinalis@SMA_ENSCINP00000024280[2][RRM1:100%][KOG0113:100%]Tetrahymena thermophila_SB210@SMA_Q23GR5_TETTH[RRM3][KOG0128]
Saccharomycetaceae@PRO_XP_453677[6][RRM1:100%*][KOG4209:100%*]Saccharomyces cerevisiae@PRO_YIR001C[3][RRM1:100%*][PABP:100%*][KOG4209:100%*]
Candida_glabrata@PRO_XP_447800[3][RRM1:100%*][KOG4209:100%*]Vanderwaltozyma polyspora_DSM_70294@REF_XP_001643854[RRM1][KOG4209]
Trichomonas vaginalis_G3@REF_XP_001305136[RRM1][KOG4209]Eukaryota@PRO_ENSCSAVP00000003369[259][RRM1:100%*****][put-sr:19%***][PABP:27%****][KOG4209:100%*****]
Dictyostelium_discoideum@PRO_XP_642788[4][RRM1:100%*][KOG4209:100%*]Caenorhabditis@REF_XP_001670634[10][RRM1:100%**][KOG4209:100%**]
Caenorhabditis elegans@PRO_T08B6_5[3][RRM1:100%*][KOG4209:100%*]Ciona@PRO_ENSCSAVP00000010162[3][RRM1:100%*][KOG4209:100%*]
Arabidopsis thaliana@PRO_NP_180012[3][RRM1:100%*]Volvox carteri@PRO_jgi_Volca1_103724[RRM1][put-sr][KOG0591]
Physcomitrella patens@PRO_jgi_Phypa1_1_167236[RRM1][KOG4209]Magnoliophyta@PRO_IMGA_AC160842_25_1[14][RRM1:100%**][KOG3702:79%**][.KOG4209:21%*]
Physcomitrella patens@PRO_jgi_Phypa1_1_96043[RRM1]Tetrapoda@PRO_ENSMODP00000004174[30][RRM4:40%**][.RRM3:37%**][.RRM2:23%*][put-sr:97%***][KOG0112:100%***]Leishmania@REF_XP_848168[4][RRM3:100%*][put-sr:100%*][KOG0147:75%*]
Embryophyta@PRO_28611_m000102[9][RRM2:100%**][put-sr:89%**][KOG0154:100%**]Phytophthora ramorum@PRO_jgi_Phyra1_1_77702[RRM1][KOG0154]
Embryophyta@PRO_jgi_Phypa1_1_161416[8][RRM1:100%**][put-sr:88%*][KOG0154:88%*][.KOG0147:12%]Dictyostelium discoideum_AX4@PRO_XP_646990[2][RRM1:100%][put-sr:100%][KOG0147:100%]
Tetrapoda@SMA_ENSPTRP00000025797[17][RRM1:100%**][put-sr:88%**][RBM:82%**][KOG0154:94%**]Amniota@SMA_ENSBTAP00000020421[2][RRM1:50%][.RRM2:50%][KOG0110:100%]
Plasmodium@REF_XP_678221[6][RRM1:100%*][KOG1365:100%*]Trypanosoma@REF_XP_813187[4][RRM2:100%*][KOG4211:100%*]
Caenorhabditis elegans@PRO_Y73B6BL_33[3][RRM1:100%*][KOG4211:100%*]Paramecium tetraurelia@REF_XP_001462005[RRM2][KOG4211]
Strongylocentrotus purpuratus@REF_XP_793087[2][RRM1:100%][KOG4211:100%]Coelomata@SMA_Q5E9J1_BOVIN[34][RRM3:68%***][.RRM2:18%*][.RRM1:15%*][hnRNP:32%**][KOG4211:100%***]
Ciona savignyi@PRO_ENSCSAVP00000001587[RRM5][KOG4307]Physcomitrella patens@PRO_jgi_Phypa1_1_162342[RRM3][KOG1365]
core_eudicotyledons@PRO_NP_188725[3][RRM2:67%][.RRM1:33%][hnRNP:67%][KOG1365:100%*]Thalassiosira pseudonana@PRO_jgi_Thaps3_5686[RRM2][KOG4211]
Caenorhabditis elegans@PRO_W02D3_11b[4][RRM1:100%*][KOG4211:100%*]Oryzias latipes@PRO_ENSORLP00000025180[RRM2][put-sr][KOG4307]
Tetrahymena thermophila_SB210@REF_XP_001023750[RRM2][KOG1365]Danio rerio@PRO_ENSDARP00000069459[2][RRM2:100%][KOG4211:100%]Eumetazoa@PRO_ENSCINP00000003632[278][RRM2:76%*****][.RRM1:24%****][hnRNP:41%****][.GRSRBP:17%***][KOG4211:100%*****]
Volvox carteri@PRO_jgi_Volca1_117772[RRM1][KOG1365]Caenorhabditis briggsae@SMA_Q626N2_CAEBR[RRM1][KOG1365]Xenopus@SMA_Q6GL26_XENTR[3][RRM1:100%*][KOG4211:100%*]Xenopus tropicalis@SMA_UPI000069EA05[RRM1][KOG4211]
Danio rerio@SMA_UPI0000546C4F[RRM1][KOG4211]Theileria_annulata@REF_XP_954308[2][RRM1:100%]
Theileria@SMA_Q4N143_THEPA[2][RRM1:100%][KOG0128:100%]Trypanosomatidae@SMA_Q381I4_9TRYP[2][RRM1:50%][.RRM2:50%][KOG0127:100%]
Entamoeba histolytica_HM-1_IMSS@REF_XP_650506[2][RRM1:100%]Schizosaccharomyces pombe_972h-@PRO_NP_594609[2][RRM1:100%][KOG4660:100%]
Cryptosporidium@PRO_XP_626158[5][RRM1:100%*][KOG0144:100%*]Phaeodactylum tricornutum@PRO_jgi_Phatr2_8457[RRM1][KOG0122]
Trypanosoma brucei@SMA_Q57WD0_9TRYP[RRM2][KOG0110]Ciona@PRO_ENSCSAVP00000005376[7][RRM1:100%*][KOG0116:57%*][.KOG2141:14%]Euteleostomi@PRO_ENSMODP00000021210[88][RRM2:95%****][.RRM1:5%*][nucleolin:67%****][KOG0123:99%****]
Takifugu rubripes@SMA_UPI00003645BC[RRM1]Volvox carteri@PRO_jgi_Volca1_120369[RRM1][put-sr][KOG0147]
Arabidopsis thaliana@SMA_Q9FFR1_ARATH[29][RRM1:38%**][.RRM2:34%**][.RRM4:14%*][.RRM3:14%*][PABP:28%**][KOG0123:100%***]
80 - hnRNP
61
83 - PABP
74
85 - SRrp
73 - SART3
Fig. S9
116
71
71
78
67
61
88
52
57
85
77
65
87
87
72
56
61 53
52
80
Solanum tuberosum@SMA Q2XTB3 SOLTU[2][RRM1:100%][hnRNP:100%][KOG1190:100%]Tetrahymena thermophila_SB210@REF_XP_001013166[3][RRM1:100%*][KOG0123:100%*]
Saccharomyces cerevisiae@PRO_YMR302C[2][RRM1:100%]Tetrahymena thermophila_SB210@REF_XP_001019724[2][RRM1:100%]
Plasmodium@SMA_Q6LFK1_PLAF7[2][RRM1:100%][KOG1190:100%]Trichomonas vaginalis_G3@REF_XP_001324476[RRM3][KOG0110]
Trichocomaceae@REF_XP_658025[3][RRM3:100%*][KOG0110:100%*]Phytophthora@PRO_jgi_Phyra1_1_74707[2][RRM3:100%][KOG0110:100%]
Volvox carteri@PRO_jgi_Volca1_63158[RRM2][KOG0110]Encephalitozoon_cuniculi@SMA_Q8SR30_ENCCU[3][RRM3:100%*][put-sr:100%*][KOG0123:100%*]
Guillardia theta@REF_NP_113380[2][RRM1:50%][.RRM3:50%]Phytophthora@PRO_jgi_Physo1_1_140019[2][RRM1:100%][KOG0116:100%]
Plasmodium_falciparum_3D7@SMA_Q4Z240_PLABE[3][RRM1:67%][.RRM2:33%]Cryptosporidium@PRO_XP_626331[5][RRM1:100%*][KOG0146:100%*]
Paramecium tetraurelia@REF_XP_001454919[RRM5][KOG0110]Entamoeba histolytica_HM-1_IMSS@REF_XP_655058[2][RRM4:50%][.RRM5:50%][KOG0110:100%]
Cyanidioschyzon merolae@PRO_gnl_CMER_CMO246C[RRM5][KOG0110]Giardia lamblia_ATCC_50803@SMA_Q7R479_GIALA[RRM4][KOG0110]
Tetrahymena thermophila_SB210@REF_XP_001020766[2][RRM5:100%][KOG0110:100%]Eukaryota@REF_XP_001670884[186][RRM5:44%****][.RRM6:28%***][.RRM4:12%***][.RRM3:10%**][KOG0110:100%*****]
Encephalitozoon_cuniculi@PRO_NP_597181[3][RRM3:67%][.RRM2:33%][KOG0110:100%*]Trichomonas vaginalis_G3@REF_XP_001324476[RRM4][KOG0110]
Cryptosporidium@PRO_XP_627799[5][RRM5:100%*][KOG0110:100%*]Ciona intestinalis@SMA_ENSCINP00000023563[2][RRM1:100%][KOG0108:100%]
Trypanosomatidae@PRO_XP_843959[10][RRM3:70%*][.RRM1:20%][.RRM2:10%]Plasmodium@SMA_Q4XDU8_PLACH[8][RRM1:100%**]
Trypanosoma_cruzi@REF_XP_810070[3][RRM1:100%*]Trichomonas vaginalis_G3@REF_XP_001579646[RRM1]
Dictyostelium discoideum_AX4@SMA_Q552N9_DICDI[3][RRM1:100%*][KOG0148:100%*]Cryptosporidium@PRO_XP_001388131[4][RRM1:100%*][KOG0117:50%][.KOG1015:50%]Apicomplexa@SMA_Q5PY68_TOXGO[2][RRM1:100%][KOG0116:50%][.KOG1015:50%]Theileria@REF_XP_951908[5][RRM1:100%*][KOG0117:40%]
Paramecium tetraurelia@REF_XP_001432122[2][RRM1:100%][KOG0123:50%][.KOG0147:50%]Tetrahymena_thermophila@REF_XP_001019281[7][RRM1:71%*][.RRM2:29%][KOG0123:57%*][.KOG4205:43%*]
Ostreococcus tauri@PRO_jgi_Ostta4_34258[RRM2]Phytophthora@PRO_jgi_Phyra1_1_77488[2][RRM1:100%][KOG4205:100%]
Phytophthora sojae@PRO_jgi_Physo1_1_139998[RRM1]Aureococcus anophagefferens@PRO_jgi_Auran1_71372[2][RRM3:50%][.RRM2:50%][put-sr:100%][KOG1178:100%]
Amniota@PRO_ENSETEP00000003776[37][RRM1:100%***][LA:97%***][KOG4213:100%***]Gibberella zeae@SMA_Q4ILE0_GIBZE[RRM1]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_44395[RRM1]Volvox carteri@PRO_jgi_Volca1_90315[RRM1]
Poaceae@PRO_8373_m000321_c0161G04[4][RRM1:100%*][KOG4205:75%*][.KOG4211:25%]Arabidopsis thaliana@SMA_Q681R8_ARATH[3][RRM1:100%*][KOG4205:100%*]
Embryophyta@PRO_28180_m000395[5][RRM1:100%*][KOG0124:100%*]Sophophora@REF_NP_648606[4][RRM1:100%*]
Thalassiosira pseudonana@PRO_jgi_Thaps3_24369[RRM1]Tetrahymena thermophila_SB210@REF_XP_001014712[2][RRM1:100%][KOG4211:100%]
Paramecium tetraurelia@REF_XP_001425448[2][RRM1:100%][KOG4205:50%][.KOG0131:50%]Phytophthora@PRO_jgi_Phyra1_1_76845[2][RRM1:100%][KOG0123:100%]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_44442[RRM1][KOG4211]Filobasidiella_neoformans@SMA_Q55YF3_CRYNE[2][RRM1:100%]
Sophophora@REF_XP_001358879[4][RRM2:100%*]Culicidae@PRO_AGAP003171-PA[8][RRM2:100%**][KOG0148:38%*]
Plasmodium@PRO_XP_966051[4][RRM2:75%*][.RRM1:25%][put-sr:50%][KOG0147:25%]Magnoliophyta@PRO_15974_m000013_AZM5_17589[12][RRM2:92%**][.RRM1:8%][KOG0123:8%]
Viridiplantae@PRO_jgi_Chlre3_99594[54][RRM1:100%***][KOG0123:6%*]Ostreococcus@PRO_jgi_Ost9901_3_7913[5][RRM1:100%*][KOG0131:20%]
Trypanosoma_brucei@PRO_XP_829593[3][RRM1:100%*]Magnoliophyta@PRO_NP_189032[9][RRM1:100%**][put-sr:100%**][KOG0670:100%**]
Ostreococcus tauri@PRO_jgi_Ostta4_24260[RRM1]Aedes aegypti@REF_XP_001655024[RRM1][put-sr][KOG1984]
Trypanosomatidae@SMA_Q388M7_9TRYP[10][RRM1:100%**]Filobasidiella_neoformans@SMA_Q55QJ2_CRYNE[2][RRM1:100%][KOG0120:100%]
Dictyostelium discoideum_AX4@REF_XP_637725[RRM1][put-sr][KOG0120]Bilateria@SMA_U2AF2_DROME[24][RRM1:100%***][put-sr:100%***][snRNP:58%**][KOG0120:100%***]
Leishmania@REF_XP_001565981[5][RRM2:80%*][.RRM1:20%][put-sr:100%*][KOG0147:80%*]Trypanosoma@PRO_XP_951655[7][RRM2:100%*][put-sr:100%*][KOG0109:100%*]
Trypanosoma_cruzi@REF_XP_817546[3][RRM3:100%*][put-sr:100%*][KOG0109:100%*]Trypanosoma_brucei@PRO_XP_951655[4][RRM3:100%*][put-sr:100%*][KOG0109:100%*]
Drosophila pseudoobscura@REF_XP_001355406[2][RRM1:100%][KOG0128:100%]Ostreococcus lucimarinus@PRO_jgi_Ost9901_3_28918[RRM1]
Giardia lamblia_ATCC_50803@REF_XP_001706513[2][RRM1:100%][KOG0110:100%]Entamoeba histolytica_HM-1_IMSS@REF_XP_654661[2][RRM1:100%]
Yarrowia lipolytica@SMA_Q6C378_YARLI[RRM2][KOG0123]Apis mellifera@SMA_UPI00003BFBCE[RRM1][put-sr][KOG2193]
Aedes aegypti@PRO_AAEL006876-PA[2][RRM1:100%][KOG2193:100%]Hydra magnipapillata@SMA_Q9GV12_HYDMA[RRM3][KOG0335]
Hydra magnipapillata@SMA_Q9GV12_HYDMA[RRM1][KOG0335]Hydra magnipapillata@SMA_Q9GV12_HYDMA[RRM2][KOG0335]
Theileria@SMA_Q4N895_THEPA[5][RRM1:100%*]Babesia bovis@REF_XP_001608797[RRM1]
Paramecium tetraurelia@REF_XP_001451287[2][RRM2:100%][KOG4205:50%][.KOG0131:50%]Tetrahymena thermophila_SB210@SMA_Q23DH4_TETTH[2][RRM2:100%][KOG4211:100%]
Plasmodium@PRO_XP_966051[2][RRM1:100%][put-sr:50%][KOG0147:50%]Encephalitozoon_cuniculi@PRO_XP_965888[3][RRM1:100%*][KOG4209:100%*]
Pezizomycotina@REF_XP_001226806[5][RRM1:100%*]Pichia stipitis_CBS_6054@PRO_XP_001384763[2][RRM1:100%][KOG0123:100%]
Ajellomyces capsulatus_NAm1@REF_XP_001536207[RRM1][KOG0128]Trichocomaceae@SMA_Q2U0H3_ASPOR[6][RRM1:100%*][KOG0128:100%*]Saccharomycetaceae@REF_XP_001643044[3][RRM1:100%*][KOG0128:100%*]
Pezizomycotina@REF_XP_001593549[7][RRM1:100%*][KOG0128:71%*][.KOG0123:14%]Paramecium tetraurelia@REF_XP_001455469[RRM1][KOG0117]
Tetrahymena thermophila_SB210@SMA_Q23GR5_TETTH[2][RRM1:100%][KOG0128:100%]Pichia stipitis_CBS_6054@PRO_XP_001384763[2][RRM3:100%][KOG0123:100%]
Guillardia theta@SMA_Q98RZ7_GUITH[2][RRM3:100%][KOG0123:100%]Phytophthora@PRO_jgi_Phyra1_1_76845[2][RRM2:100%][KOG0123:100%]
Aureococcus anophagefferens@PRO_jgi_Auran1_8214[RRM1]Thalassiosira pseudonana@PRO_jgi_Thaps3_1374[RRM2][KOG0116]
Entamoeba histolytica_HM-1_IMSS@REF_XP_654966[3][RRM1:100%*][KOG0147:67%]Phaeodactylum tricornutum@PRO_jgi_Phatr2_44442[RRM2][KOG4211]
Oryza sativa_japonica_cultivar-group@SMA_Q6ZG86_ORYSA[RRM1][KOG0116]rosids@SMA_Q2PEQ3_TRIPR[3][RRM1:100%*][NTF:33%][KOG0116:100%*]
Oryza sativa_japonica_cultivar-group@SMA_Q7Y1L6_ORYSA[RRM1][KOG0116]Embryophyta@PRO_NP_001052571[15][RRM1:100%**][NTF:27%*][KOG0116:100%**]
Schizosaccharomyces_pombe@PRO_NP_593531[3][RRM2:100%*][nucleolin:100%*][KOG0147:100%*]Dikarya@SMA_Q2U4B5_ASPOR[53][RRM2:100%***][nucleolin:6%*][KOG0148:79%***][.KOG0131:11%*][.KOG0127:6%*]
Trichocomaceae@REF_XP_001397624[8][RRM1:100%**][KOG1924:12%]Phytophthora@PRO_jgi_Phyra1_1_83430[2][RRM1:100%]
Ajellomyces capsulatus_NAm1@REF_XP_001541377[RRM1]Yarrowia lipolytica@PRO_XP_504609[2][RRM1:100%]
Eumetazoa@REF_XP_001631718[111][RRM1:100%****][KOG0108:14%**][.KOG0116:8%**][.KOG0921:5%*]Ciona@PRO_ENSCSAVP00000001842[3][RRM1:100%*]
Saccharomycetales@SMA_Q5A4L8_CANAL[5][RRM1:100%*]Encephalitozoon_cuniculi@SMA_Q8SSA1_ENCCU[3][RRM2:100%*][KOG4205:100%*]
Eumetazoa@PRO_ENSSARP00000000775[84][RRM1:100%****][eIF4B:68%****]Strongylocentrotus purpuratus@SMA_UPI0000583F6E[RRM1]
Apis mellifera@SMA_UPI0000519CF4[RRM1]Tribolium castaneum@SMA_UPI0000D5730A[RRM1][put-sr]
Anopheles_gambiae@PRO_AGAP000525-PA[4][RRM1:100%*]87 - eIF-4B
84 - La
60
Fig. S9
117
90
97
51
59
99
82
70
95
51 86
60
61
70 63
69
71
50
54
57
Candida glabrata@PRO XP 446891[3][RRM3:67%][ RRM2:33%][KOG0128:100%*]Saccharomyces cerevisiae@PRO_YMR268C[2][RRM3:100%][KOG0128:100%]
Debaryomyces_hansenii@PRO_XP_460681[3][RRM3:67%][.RRM2:33%][KOG0128:100%*]Pichia guilliermondii_ATCC_6260@REF_XP_001485760[RRM3][KOG0123]
Eremothecium gossypii@SMA_Q756X0_ASHGO[RRM2][KOG0128]Paramecium tetraurelia@REF_XP_001428031[RRM1]
Paramecium tetraurelia@REF_XP_001440032[RRM2]Tetrahymena thermophila_SB210@REF_XP_001031517[2][RRM1:100%]
Babesia bovis@REF_XP_001609703[RRM2][KOG0110]Theileria@REF_XP_764035[3][RRM2:67%][.RRM1:33%][KOG0110:100%*]
Tetrahymena thermophila_SB210@REF_XP_001024046[2][RRM1:100%][KOG0127:100%]Nasonia vitripennis@PRO_XP_001605703[2][RRM1:100%][KOG0127:100%]
Sophophora@PRO_CG4806-PA[5][RRM1:100%*][KOG0127:100%*]Aedes aegypti@PRO_AAEL008572-PA[2][RRM1:100%][KOG0127:100%]
Tribolium castaneum@PRO_XP_974350[3][RRM1:100%*][KOG0127:100%*]Apis mellifera@PRO_XP_624495[3][RRM1:100%*][KOG0127:100%*]
Nasonia vitripennis@PRO_XP_001605703[2][RRM2:100%][KOG0127:100%]Chordata@PRO_ENSOGAP00000005376[57][RRM2:91%***][.RRM3:7%*][RBM:47%***][KOG0127:100%****]
Nematostella vectensis@REF_XP_001631286[RRM2][KOG0127]Caenorhabditis@SMA_Q60SI3_CAEBR[2][RRM1:100%][KOG0127:100%]
Trichomonas vaginalis_G3@REF_XP_001330706[2][RRM2:100%][KOG0123:50%]Embryophyta@PRO_jgi_Phypa1_1_201182[12][RRM2:100%**][KOG0127:100%**]
Ostreococcus@PRO_jgi_Ost9901_3_26255[3][RRM2:100%*][KOG0127:100%*]Chlamydomonas reinhardtii@PRO_jgi_Chlre3_186870[RRM2][KOG0127]
Tetrahymena thermophila_SB210@SMA_Q234T4_TETTH[2][RRM2:100%][put-sr:100%][KOG0147:100%]Trichomonas vaginalis_G3@REF_XP_001318929[2][RRM1:100%][KOG0125:100%]
Embryophyta@PRO_jgi_Phypa1_1_217831[33][RRM3:91%***][.RRM1:9%*][KOG0117:100%***]Oryza sativa_japonica_cultivar-group@PRO_NP_001067112[2][RRM2:100%][put-sr:100%][KOG0117:100%]Poaceae@SMA_Q2QN68_ORYSA[2][RRM1:100%][put-sr:100%][KOG0117:100%]
Pezizomycotina@REF_XP_001596374[20][RRM2:100%**][put-sr:10%][KOG0116:35%*]Schizosaccharomyces_pombe@PRO_NP_595090[2][RRM2:100%]
Entamoeba histolytica_HM-1_IMSS@REF_XP_651599[3][RRM2:100%*][KOG0127:100%*]Entamoeba_histolytica@SMA_Q50XT4_ENTHI[6][RRM2:50%*][.RRM3:33%][.RRM1:17%][KOG0123:100%*]
Yarrowia lipolytica@PRO_XP_500351[3][RRM1:100%*][KOG0123:100%*]Aureococcus anophagefferens@PRO_jgi_Auran1_17889[RRM1][KOG4207]
Tribolium castaneum@PRO_XP_970765[3][RRM2:100%*][KOG0127:100%*]Yarrowia lipolytica@PRO_XP_504884[3][RRM3:100%*][KOG0123:100%*]Endopterygota@SMA_UPI0000D56681[3][RRM1:100%*][put-sr:67%][KOG1080:67%]
Euteleostomi@PRO_ENSORLP00000016244[25][RRM1:100%***][KOG1080:68%**]Nematostella vectensis@REF_XP_001636608[RRM1]
Leishmania infantum_JPCM5@PRO_XP_001468615[RRM1]Trypanosoma_cruzi@REF_XP_805765[3][RRM1:100%*][KOG0122:100%*]
Dictyostelium discoideum_AX4@PRO_XP_641693[3][RRM1:100%*][KOG0122:100%*]Yarrowia lipolytica@PRO_XP_503515[3][RRM1:100%*][KOG0122:100%*]
Cryptococcus_neoformans_var._neoformans@PRO_XP_567824_RRMSaccharomycetales@REF_XP_001525703[9][RRM1:100%**][KOG0122:100%**]Saccharomycetales@REF_XP_001646780[11][RRM1:100%**][KOG0122:100%**]
Eukaryota@SMA_Q4L1A3_WHEAT[169][RRM1:100%*****][KOG0122:99%*****]Medicago truncatula@SMA_Q1SH93_MEDTR[2][RRM1:100%][KOG0122:100%]
Schistosoma japonicum@SMA_Q5DF32_SCHJA[RRM1][KOG0122]Cyanidioschyzon merolae@PRO_gnl_CMER_CMH159C[RRM1][KOG0122]Caenorhabditis@PRO_F22B5_2[5][RRM1:100%*][KOG0122:100%*]
Nematostella vectensis@REF_XP_001627253[2][RRM1:100%][KOG0921:100%]Dictyostelium discoideum_AX4@SMA_Q54I03_DICDI[RRM1][put-sr]
Oryza_sativa@SMA_Q33B10_ORYSA[3][RRM2:100%*][KOG0117:100%*]Magnoliophyta@SMA_Q2HTD6_MEDTR[2][RRM2:100%][KOG0117:100%]
Strongylocentrotus purpuratus@REF_XP_782196[2][RRM1:100%][KOG2193:100%]Euteleostomi@PRO_ENSGACP00000007987[16][RRM1:100%**][IGF2BP:88%**][KOG2193:100%**]
Takifugu rubripes@SMA_UPI000065D15B[RRM1][KOG0117]Eumetazoa@PRO_ENSGALP00000025475[469][RRM1:100%******][hnRNP:33%*****][KOG0117:100%******]Eutheria@PRO_ENSCPOP00000011171[3][RRM1:100%*][hnRNP:67%][KOG0117:100%*]
Tribolium castaneum@PRO_XP_967803[6][RRM1:100%*][KOG0117:100%*]Apis mellifera@SMA_UPI0000514B1D[2][RRM1:100%][KOG0117:100%]
Euteleostomi@REF_XP_001086896[19][RRM1:100%**][KOG0117:100%**]Aedes aegypti@PRO_AAEL015050-PA[4][RRM1:100%*][KOG0117:100%*]
Anopheles_gambiae@PRO_AGAP002326-PA[3][RRM1:100%*]Phaeodactylum tricornutum@PRO_jgi_Phatr2_16633[RRM1][KOG0125]
Entamoeba histolytica_HM-1_IMSS@REF_XP_650669[2][RRM1:100%][KOG0145:100%]Trichomonas vaginalis_G3@REF_XP_001312349[RRM1]
Trichomonas vaginalis_G3@REF_XP_001324542[RRM1]Giardia lamblia_ATCC_50803@SMA_Q7R0N0_GIALA[RRM1]
Amniota@SMA_Q2L7G6_HUMAN[13][RRM2:85%**][.RRM1:15%][hnRNP:100%**][KOG0117:100%**]Physcomitrella patens@PRO_jgi_Phypa1_1_12664[RRM1]
Oryza_sativa@SMA_Q259U0_ORYSA[2][RRM1:100%][KOG3671:50%]rosids@PRO_30155_m001644[5][RRM1:100%*][KOG0116:20%]
Saccharomycetaceae@PRO_XP_458658[5][RRM1:100%*][KOG0921:100%*]Candida albicans_SC5314@REF_XP_715038[2][RRM1:100%][KOG0921:100%]
Lodderomyces elongisporus_NRRL_YB-4239@REF_XP_001525705[RRM1][KOG0921]Saccharomyces cerevisiae@SMA_YHH5_YEAST[3][RRM3:100%*][KOG0123:100%*]
Saccharomyces cerevisiae@PRO_YFR023W[3][RRM3:100%*][KOG0123:100%*]Candida_glabrata@PRO_XP_447635[3][RRM3:100%*][KOG0123:100%*]
Nematostella vectensis@REF_XP_001637104[RRM1]Vanderwaltozyma polyspora_DSM_70294@REF_XP_001643543[RRM3][KOG0123]
Eremothecium_gossypii@PRO_NP_984845[3][RRM3:100%*][KOG0123:100%*]Kluyveromyces lactis@PRO_XP_451368[RRM3][KOG0123]
Pezizomycotina@PRO_XP_961985[19][RRM1:100%**][put-sr:11%][KOG0116:37%*]Aureococcus anophagefferens@PRO_jgi_Auran1_69134[RRM1][put-sr]
Entamoeba histolytica_HM-1_IMSS@REF_XP_654958[3][RRM1:100%*][put-sr:100%*]Aspergillus nidulans_FGSC_A4@REF_XP_681204[2][RRM1:100%][KOG0131:100%]
Aspergillus nidulans_FGSC_A4@REF_XP_662872[2][RRM1:100%]Eurotiomycetidae@REF_XP_664326[11][RRM1:100%**][KOG0254:18%]
Sclerotiniaceae@REF_XP_001591248[2][RRM1:100%]Sordariales@PRO_XP_964541[5][RRM1:100%*]
Magnaporthe grisea_70-15@SMA_UPI000021B0CF[RRM1]Magnaporthe grisea_70-15@REF_XP_360963[2][RRM1:100%]
Paramecium tetraurelia@REF_XP_001455469[RRM3][KOG0117]Apis mellifera@PRO_XP_393878[2][RRM1:100%][put-sr:100%][KOG2193:100%]
Ciona intestinalis@PRO_ENSCINP00000008726[2][RRM1:100%][put-sr:100%][KOG2193:100%]Saccharomycetales@PRO_XP_001387063[5][RRM1:100%*]
Pichia guilliermondii_ATCC_6260@REF_XP_001486542[RRM1]Candida_glabrata@PRO_XP_445637[3][RRM1:100%*]
Saccharomyces cerevisiae@SMA_YFK2_YEAST[RRM1]Eremothecium_gossypii@PRO_NP_983970[3][RRM1:100%*]
Kluyveromyces lactis@SMA_Q6CQM2_KLULA[RRM1]Paramecium tetraurelia@REF_XP_001454919[RRM2][KOG0110]
Tetrahymena thermophila_SB210@REF_XP_001020766[2][RRM2:100%][KOG0110:100%]Tetrahymena thermophila_SB210@REF_XP_001033357[2][RRM2:100%][KOG0144:100%]
Caenorhabditis@SMA_O76366_CAEEL[3][RRM1:100%*][KOG0112:100%*]Ciona intestinalis@SMA_ENSCINP00000027547[RRM1][put-sr]
Coelomata@PRO_XP_974651[122][RRM2:68%****][.RRM1:32%***][put-sr:88%****][RBM:30%***][KOG0112:100%****]Sophophora@PRO_CG2050-PA[4][RRM3:75%*][.RRM2:25%]
Nematostella vectensis@REF_XP_001641758[RRM1][KOG0112]Nematostella vectensis@REF_XP_001632954[RRM2][KOG0112]
Strongylocentrotus purpuratus@PRO_XP_001184502[5][RRM2:80%*][.RRM1:20%][put-sr:80%*][KOG1144:80%*][.KOG0123:20%]Coelomata@PRO_ENSMMUP00000010529[79][RRM2:47%***][.RRM3:39%***][.RRM1:14%**][put-sr:92%****][KOG0112:78%****][.KOG3598:10%**]
Triturus carnifex@SMA_Q8QFS6_TRICI[RRM2][KOG0123]Anopheles gambiae_str._PEST@SMA_Q7PZY1_ANOGA[RRM1][KOG2314]
Euteleostomi@PRO_GSTENP00022906001[99][RRM3:86%****][.RRM1:9%**][.RRM2:5%*][nucleolin:62%****][KOG0123:96%****]Tetraodontidae@PRO_GSTENP00014994001[4][RRM1:50%][.RRM3:25%][.RRM2:25%][KOG0123:50%]
Solanum tuberosum@SMA_Q2XTB3_SOLTU[2][RRM1:100%][hnRNP:100%][KOG1190:100%]
55
48 - IGF2BP
2 - hnRNP
65
part of 63 - hnRNP
71 - RBM
53
+
54
Fig. S9
118
63
54
72 71
55
76
56
80
80
60
54
100
54
56
93 66
60
77 89
97
Trichomonas vaginalis G3@REF XP 001312327[RRM2][KOG0123]Trichomonas vaginalis_G3@REF_XP_001326368[RRM2][KOG0123]
Dictyostelium discoideum_AX4@SMA_Q54FZ3_DICDI[RRM1][KOG0153]Dictyostelium discoideum_AX4@PRO_XP_635179[3][RRM2:100%*][KOG0148:100%*]
Ostreococcus tauri@PRO_jgi_Ostta4_31833[RRM2][KOG0148]Candida albicans_SC5314@SMA_Q59U75_CANAL[RRM2][put-sr][KOG0148]
Aureococcus anophagefferens@PRO_jgi_Auran1_28594[RRM3][KOG0148]Phytophthora@PRO_jgi_Phyra1_1_50314[2][RRM3:100%][KOG0148:100%]
Schizosaccharomyces_pombe@PRO_NP_594243[3][RRM3:100%*][KOG0148:100%*]Eukaryota@PRO_YHR086W[145][RRM3:73%****][.RRM2:23%***][oligoU:12%**][KOG0148:91%****]
Encephalitozoon_cuniculi@PRO_NP_584552[3][RRM3:100%*][KOG0123:100%*]Dictyostelium discoideum_AX4@PRO_XP_645138[3][RRM1:100%*]
Percomorpha@SMA_Q4SDN6_TETNG[2][RRM1:100%][KOG0548:100%]Danio rerio@PRO_ENSDARP00000075089[4][RRM1:100%*][KOG0548:100%*]
Plasmodium@SMA_Q8IHX4_PLAF7[8][RRM1:100%**][KOG0144:100%**]Trichomonas vaginalis_G3@REF_XP_001307992[RRM3][KOG0123]
Trichomonas vaginalis_G3@REF_XP_001314386[2][RRM3:100%][KOG0123:100%]Trichomonas vaginalis_G3@REF_XP_001313255[RRM3][KOG0123]
Strongylocentrotus purpuratus@PRO_XP_001188888[5][RRM1:100%*][KOG0548:100%*]Clupeocephala@PRO_ENSORLP00000009616[5][RRM1:100%*][KOG0548:100%*]
Tetrahymena thermophila_SB210@REF_XP_001023234[2][RRM1:100%][KOG0153:100%]Eumetazoa@SMA_UPI0000D56CC9[76][RRM1:100%****][RBM:75%****][KOG0153:100%****]Caenorhabditis@REF_XP_001671467[6][RRM1:100%*][KOG0153:100%*]
Ciona@PRO_ENSCSAVP00000015574[4][RRM1:100%*][KOG0153:100%*]Embryophyta@PRO_jgi_Phypa1_1_185655[18][RRM1:100%**][KOG0153:100%**]
Ostreococcus@PRO_jgi_Ost9901_3_41266[3][RRM1:100%*][KOG0153:100%*]Paramecium tetraurelia@REF_XP_001451420[2][RRM1:100%][put-sr:100%]
Physcomitrella patens@PRO_jgi_Phypa1_1_137240[2][RRM1:100%][KOG3598:50%]Physcomitrella patens@PRO_jgi_Phypa1_1_161310[RRM3][KOG3598]
Arabidopsis thaliana@SMA_UPI000034F1EC[RRM2][put-sr][oligoU][KOG4206]Oryza sativa_japonica_cultivar-group@PRO_NP_001062811[3][RRM1:100%*][KOG1190:100%*]
rosids@REF_NP_193001[5][RRM1:100%*][put-sr:40%][oligoU:60%*][KOG4206:40%]Arabidopsis thaliana@SMA_O22855_ARATH[11][RRM1:100%**][FCAFPA:100%**][KOG0117:82%**]
Ricinus communis@PRO_29577_m000447[RRM1][KOG0123]Oryza sativa_japonica_cultivar-group@SMA_Q69IL3_ORYSA[RRM1][KOG0123]
Euteleostomi@SMA_UPI000061000C[15][RRM1:100%**][put-sr:100%**][KOG0112:93%**]Filobasidiella_neoformans@SMA_Q55UF0_CRYNE[2][RRM1:100%][KOG4574:100%]Pezizomycotina@SMA_Q5AW56_EMENI[10][RRM1:100%**][KOG4574:100%**]
Basidiomycota@SMA_Q55UF0_CRYNE[6][RRM2:100%*][KOG4574:100%*]Yarrowia lipolytica@PRO_XP_500252[3][RRM1:100%*][KOG4574:100%*]
Schizosaccharomyces pombe_972h-@PRO_NP_595389[2][RRM1:100%][KOG4574:100%]Trypanosoma@SMA_Q584Q1_9TRYP[3][RRM2:100%*][KOG0148:67%]
Leishmania major@SMA_Q4Q7J2_LEIMA[RRM1]Volvox carteri@PRO_jgi_Volca1_88720[RRM3]
Chlamydomonas reinhardtii@PRO_jgi_Chlre3_148816[RRM2][KOG3598]Dictyostelium discoideum_AX4@PRO_XP_629218[3][RRM2:100%*][KOG0151:100%*]
Dictyostelium discoideum_AX4@PRO_XP_629218[3][RRM1:100%*][KOG0151:100%*]Deuterostomia@SMA_PTBP1_HUMAN[23][RRM4:43%**][.RRM3:35%**][.RRM2:17%*][PTBP:83%**][KOG1190:100%***]
Physcomitrella patens@PRO_jgi_Phypa1_1_176266[RRM1][KOG1924]Oryza sativa_japonica_cultivar-group@PRO_NP_001063671[3][RRM2:100%*][KOG0123:100%*]
Physcomitrella patens@PRO_jgi_Phypa1_1_161310[RRM2][KOG3598]rosids@PRO_NP_001078046[11][RRM2:100%**][FCAFPA:91%**][KOG0117:82%**][.KOG0123:9%]
Dictyostelium discoideum_AX4@PRO_XP_644288[3][RRM1:100%*][KOG3598:100%*]Dikarya@SMA_Q4P665_USTMA[8][RRM4:100%**][KOG0117:38%*]
Schizosaccharomyces pombe@SMA_NRD1_SCHPO[RRM4]Dictyostelium discoideum_AX4@PRO_XP_644288[3][RRM2:100%*][KOG3598:100%*]
Schizosaccharomyces pombe@SMA_YCQ9_SCHPO[RRM1]Schizosaccharomyces pombe_972h-@PRO_NP_588373[2][RRM1:100%]
Entamoeba histolytica_HM-1_IMSS@REF_XP_654040[2][RRM1:50%][.RRM2:50%]Vanderwaltozyma polyspora_DSM_70294@REF_XP_001643044[RRM3][KOG0128]
Aedes aegypti@PRO_AAEL010887-PA[2][RRM6:100%][put-sr:100%][KOG1984:100%]Anopheles gambiae@SMA_ENSANGP00000026818[RRM1]
Entamoeba histolytica_HM-1_IMSS@SMA_Q517P3_ENTHI[2][RRM1:100%]Volvox carteri@PRO_jgi_Volca1_107013[RRM3][KOG0117]
Kluyveromyces lactis@PRO_XP_454447[3][RRM3:100%*][KOG0128:100%*]Xenopus laevis@SMA_Q569S7_XENLA[RRM1][KOG4205]
Tetrahymena thermophila_SB210@SMA_Q22FI2_TETTH[RRM1]Dictyostelium discoideum_AX4@SMA_Q54GS2_DICDI[RRM1]
Plasmodium@REF_XP_726028[8][RRM1:100%**]Trypanosoma_cruzi@REF_XP_803950[4][RRM1:100%*]
Apis mellifera@PRO_XP_394565[3][RRM1:100%*][KOG0147:100%*]Anopheles_gambiae@SMA_ENSANGP00000016551[2][RRM1:100%][KOG0148:50%]
Caenorhabditis@SMA_Q95QL3_CAEEL[2][RRM1:100%][KOG0131:50%]Nematostella vectensis@REF_XP_001637979[RRM1][KOG0149]
Dictyostelium discoideum_AX4@SMA_Q54D57_DICDI[RRM3][KOG0145]Paramecium tetraurelia@REF_XP_001425411[RRM1][KOG0123]
Paramecium tetraurelia@REF_XP_001459353[3][RRM1:100%*][KOG0123:100%*]Tetrahymena thermophila_SB210@REF_XP_001023043[2][RRM2:100%][KOG0144:100%]
Tetrapoda@REF_XP_001092330[39][RRM1:59%***][.RRM2:41%**][PTBP:97%***][KOG1190:100%***]Coelomata@REF_XP_424912[51][RRM2:63%***][.RRM3:31%**][.RRM1:6%*][PTBP:84%***][KOG1190:100%***]
Magnoliophyta@SMA_Q1RYN5_MEDTR[5][RRM2:80%*][.RRM1:20%][put-sr:20%][hnRNP:60%*][KOG1190:80%*][.KOG2946:20%]Coelomata@SMA_UPI0000587D6B[17][RRM3:88%**][.RRM2:12%][UMH:82%**][KOG0124:100%**]
Candida albicans_SC5314@REF_XP_718102[2][RRM1:100%][KOG1548:100%]Paramecium tetraurelia@REF_XP_001444867[RRM2]
Oryza sativa_japonica_cultivar-group@REF_NP_001053200[2][RRM1:100%][KOG1548:100%]Tribolium castaneum@PRO_XP_969008[2][RRM2:100%][KOG0331:100%]Caenorhabditis elegans@SMA_Q9BL57_CAEEL[RRM1][UMH][KOG1548]
Caenorhabditis@SMA_Q18265_CAEEL[2][RRM1:100%][KOG0921:100%]Sophophora@SMA_Q294Y2_DROPS[2][RRM1:100%][KOG1995:100%]
Coelomata@PRO_ENSDARP00000069729[324][RRM1:100%*****][KOG1995:79%*****][.KOG0921:15%***]Strongylocentrotus purpuratus@PRO_XP_001196853[5][RRM1:100%*][KOG1995:100%*]
Magnoliophyta@SMA_Q69TN3_ORYSA[5][RRM1:100%*][put-sr:60%*][KOG1995:100%*]Coxiella_burnetii@PRO_YP_001424503[7][RRM1:100%*][PROK:100%*][KOG0113:100%*]Coxiella_burnetii@SMA_Q83CD7_COXBU[6][RRM1:100%*][PROK:100%*][KOG0108:100%*]
Embryophyta@PRO_jgi_Phypa1_1_44443[2][RRM2:100%][KOG0149:100%]Embryophyta@PRO_29900_m001607[30][RRM2:100%***][oligoU:43%**][KOG4205:87%***][.KOG0149:13%*]
Oryza sativa_japonica_cultivar-group@SMA_Q2R1J0_ORYSA[RRM2][KOG0148]Dictyostelium discoideum_AX4@SMA_Q55CC1_DICDI[RRM1]
Paramecium tetraurelia@REF_XP_001454031[2][RRM1:100%][put-sr:100%]Tetrahymena thermophila_SB210@REF_XP_001030321[2][RRM1:100%]
Eukaryota@REF_XP_001541559[147][RRM1:100%****][KOG0114:100%****]Encephalitozoon_cuniculi@SMA_Q8SWE3_ENCCU[3][RRM1:100%*][KOG0114:100%*]
Trichomonas vaginalis_G3@REF_XP_001325623[RRM1][KOG0114]Saccharomycetaceae@PRO_XP_458197[4][RRM1:100%*][KOG0114:100%*]
Lodderomyces elongisporus_NRRL_YB-4239@REF_XP_001527422[RRM1][KOG0114]Candida albicans_SC5314@REF_XP_714695[2][RRM1:100%][KOG0114:100%]
Caenorhabditis@SMA_Q621Q9_CAEBR[2][RRM1:100%][KOG1947:100%]Trichomonas vaginalis_G3@REF_XP_001328261[RRM1]
Euteleostomi@SMA_ENSPTRP00000017835[12][RRM1:100%**][KOG0145:42%*][.KOG0123:33%*]Trichomonas vaginalis_G3@REF_XP_001301635[RRM2][KOG0123]
Babesia bovis@REF_XP_001609195[RRM2][put-sr][KOG0127]Theileria@SMA_Q4UFR5_THEAN[5][RRM2:100%*][KOG0127:100%*]
Tetrahymena thermophila_SB210@SMA_Q246Z1_TETTH[2][RRM2:100%][KOG0127:100%]Entamoeba histolytica_HM-1_IMSS@SMA_Q50UL9_ENTHI[4][RRM1:100%*][KOG0127:100%*]
Phytophthora ramorum@PRO_jgi_Phyra1_1_79608[2][RRM4:100%][KOG0127:100%]Phytophthora sojae@PRO_jgi_Physo1_1_132702[RRM4][KOG0127]
Theileria@REF_XP_951783[5][RRM1:100%*][KOG0127:100%*]Plasmodium@REF_XP_001614741[10][RRM2:90%**][.RRM1:10%][KOG0123:10%]
Debaryomyces hansenii@SMA_Q6BS29_DEBHA[RRM1]Candida_glabrata@PRO_XP_446891[3][RRM3:67%][.RRM2:33%][KOG0128:100%*]
44
14 - RBM
78 - OligoU
Fig. S9
119
81
63
59
67
62
53
97 65
55
63
Schizosaccharomyces pombe@PRO NP 594970[3][RRM2:100%*][KOG4210:100%*]Pezizomycotina@REF_XP_661031[11][RRM2:82%**][.RRM1:18%][put-sr:9%][KOG4210:27%*][.KOG0149:18%]
Saccharomycetales@REF_XP_719745[23][RRM2:87%**][.RRM1:13%*][KOG4210:100%***]Strongylocentrotus purpuratus@SMA_UPI0000583E2F[RRM1]
Nematostella vectensis@REF_XP_001641436[RRM1]Apocrita@PRO_XP_001602363[4][RRM1:100%*][KOG1832:50%]
Culicidae@PRO_AAEL001997-PA[6][RRM1:100%*]Sophophora@PRO_CG3594-PA[5][RRM1:100%*][KOG0110:100%*]
Cryptococcus_neoformans_var._neoformans@PRO_XP_570477_RRMPhaeodactylum tricornutum@PRO_jgi_Phatr2_32836[RRM1]
Phytophthora@PRO_jgi_Physo1_1_136292[2][RRM1:100%]Schizosaccharomyces_pombe@PRO_NP_596033[3][RRM1:100%*]
Ustilago maydis_521@SMA_Q4PGP7_USTMA[RRM1]Neurospora_crassa@PRO_XP_964518[3][RRM1:100%*]
Sordariomycetes@PRO_XP_389032[6][RRM1:100%*]Trichocomaceae@SMA_Q4WWL6_ASPFU[2][RRM1:100%]
Cryptosporidium@PRO_XP_627799[5][RRM2:100%*][KOG0110:100%*]Tetrahymena thermophila_SB210@SMA_Q22V25_TETTH[RRM1][KOG2476]
Schizosaccharomyces pombe@SMA_MSA1_SCHPO[RRM1][KOG0123]Sclerotiniaceae@REF_XP_001594190[2][RRM1:100%][put-sr:100%][KOG0123:100%]
Saccharomycetales@REF_XP_001482891[11][RRM1:100%**][KOG0123:55%*]Magnoliophyta@SMA_Q9C5A7_ARATH[7][RRM3:71%*][.RRM4:29%][KOG0110:100%*]
Paramecium tetraurelia@REF_XP_001454919[RRM4][KOG0110]Tetrahymena thermophila_SB210@REF_XP_001020766[2][RRM4:100%][KOG0110:100%]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_20740[RRM4][KOG0110]Thalassiosira pseudonana@PRO_jgi_Thaps3_268689[RRM4][KOG0110]
Plasmodium vivax@REF_XP_001617268[RRM3][KOG0110]Ornithorhynchus anatinus@REF_XP_001519607[RRM2][KOG0110]
Babesia bovis@REF_XP_001609703[RRM4][KOG0110]Cryptosporidium@PRO_XP_627799[5][RRM4:100%*][KOG0110:100%*]
Dictyostelium discoideum_AX4@SMA_Q54PB2_DICDI[RRM4][KOG0110]Dikarya@REF_XP_721604[52][RRM4:88%***][.RRM3:6%*][.RRM2:6%*][KOG0110:100%***]
Filobasidiella_neoformans@PRO_XP_569873[2][RRM4:50%][.RRM3:50%][KOG0110:100%]Caenorhabditis@SMA_Q9XU67_CAEEL[3][RRM4:33%][.RRM3:33%][.RRM5:33%][KOG0110:100%*]
Ostreococcus@PRO_jgi_Ost9901_3_710[3][RRM4:100%*][KOG0110:100%*]Apocrita@PRO_XP_001605134[8][RRM4:50%*][.RRM5:50%*][KOG0110:100%**]Euteleostomi@SMA_UPI00004BE5E2[55][RRM5:64%***][.RRM4:24%**][.RRM3:5%*][.RRM2:5%*][put-sr:9%*][KOG0110:100%****]
Phytophthora sojae@PRO_jgi_Physo1_1_129427[RRM4][KOG0110]Entamoeba histolytica_HM-1_IMSS@REF_XP_655058[2][RRM4:50%][.RRM3:50%][KOG0110:100%]
Nematostella vectensis@REF_XP_001639550[RRM5][KOG0110]Strongylocentrotus purpuratus@SMA_UPI0000583F7B[RRM1][KOG0110]
Chironomus tentans@SMA_Q95ZH1_CHITE[RRM5][KOG0110]Culicidae@PRO_AAEL004075-PA[8][RRM5:75%*][.RRM1:25%][KOG0110:100%**]Drosophila melanogaster@SMA_Q9VT19_DROME[RRM3][KOG0110]
Yarrowia lipolytica@PRO_XP_503802[3][RRM1:100%*][KOG0113:100%*]Saccharomycetales@PRO_XP_001385249[10][RRM1:100%**][KOG0113:100%**]
Saccharomycetales@PRO_NP_984033[10][RRM1:100%**][put-sr:10%][KOG0113:100%**]Kluyveromyces lactis@PRO_XP_452557[3][RRM1:100%*][KOG0113:100%*]
Apis mellifera@PRO_XP_623573[3][RRM1:100%*][KOG0113:100%*]Entamoeba histolytica_HM-1_IMSS@SMA_Q51GC5_ENTHI[RRM1][KOG0144]
Entamoeba histolytica_HM-1_IMSS@SMA_Q50S61_ENTHI[2][RRM1:100%][KOG0148:50%]Entamoeba histolytica_HM-1_IMSS@REF_XP_648918[2][RRM1:100%][KOG0148:100%]
Bigelowiella natans@SMA_Q3LVZ3_CHLS6[RRM1][KOG0415]Trichomonas vaginalis_G3@REF_XP_001324009[RRM1][KOG0415]
Eukaryota@PRO_jgi_Ostta4_3181[197][RRM1:100%*****][put-sr:42%****][cyclophilin:23%***][KOG0415:97%*****]Debaryomyces_hansenii@PRO_XP_459815[3][RRM1:100%*][KOG0415:100%*]
Ciona@PRO_ENSCSAVP00000001345[3][RRM1:100%*][KOG0113:100%*]Nematostella vectensis@REF_XP_001634361[RRM1][KOG0113]Embryophyta@PRO_29657_m000467[9][RRM1:100%**][put-sr:22%][snRNP:44%*][KOG0113:100%**]
Deuterostomia@PRO_XP_001178221[66][RRM1:100%****][put-sr:62%***][snRNP:71%***][KOG0113:100%****]Tribolium castaneum@PRO_XP_966565[3][RRM1:100%*][KOG0113:100%*]
Entamoeba histolytica_HM-1_IMSS@REF_XP_656357[2][RRM1:100%][KOG0113:100%]Phytophthora@PRO_jgi_Phyra1_1_44765[2][RRM1:100%][put-sr:50%][KOG0113:100%]
Aureococcus anophagefferens@PRO_jgi_Auran1_34517[2][RRM1:100%][put-sr:50%][KOG0113:100%]Aspergillus fumigatus_Af293@PRO_XP_753306[2][RRM1:100%][KOG0113:100%]
Schizosaccharomyces_pombe@PRO_NP_593779[3][RRM1:100%*][KOG0113:100%*]Tetrahymena thermophila_SB210@REF_XP_001011681[2][RRM1:100%][KOG0113:100%]
Ostreococcus@PRO_jgi_Ostta4_11066[3][RRM1:100%*][KOG0113:100%*]Eukaryota@SMA_Q94LP1_ORYSA[146][RRM1:100%****][put-sr:38%****][snRNP:10%**][KOG0113:100%****]
Paramecium tetraurelia@REF_XP_001457841[3][RRM1:100%*][put-sr:100%*][KOG0113:100%*]Coelomata@PRO_AAEL011340-PB[3][RRM1:100%*][put-sr:33%][KOG0113:100%*]Felis catus@PRO_ENSFCAP00000006212[RRM1][put-sr][KOG0113]
Rattus norvegicus@PRO_ENSRNOP00000048879[RRM1][snRNP][KOG0113]Geobacter uraniumreducens_Rf4@SMA_Q2DJM1_9DELT[3][RRM1:100%*][PROK:100%*][KOG0108:100%*]
Beggiatoa sp._PS@REF_ZP_02002958[RRM1][PROK][KOG0145]Pedobacter sp._BAL39@REF_ZP_01882770[RRM1][PROK][KOG0108]
Leptospira@PRO_YP_000459[9][RRM1:100%**][PROK:100%**][KOG0108:100%**]Entamoeba_histolytica@REF_XP_649106[3][RRM2:67%][.RRM1:33%][KOG0123:67%][.KOG0125:33%]
Candidatus Protochlamydia_amoebophila_UWE25@SMA_Q6MCT2_PARUW_RRSyntrophobacter fumaroxidans_MPOB@PRO_YP_845575[2][RRM1:100%][PROK:100%]Schizosaccharomyces_pombe@PRO_NP_595396[3][RRM1:100%*][put-sr:100%*][KOG0120:100%*]Chlamydomonadales@PRO_jgi_Volca1_48801[2][RRM1:100%][KOG0120:100%]
Tetrahymena thermophila_SB210@REF_XP_001021657[2][RRM1:100%][put-sr:100%][KOG0120:100%]Yarrowia lipolytica@PRO_XP_503754[2][RRM1:100%][KOG0120:100%]
Tetrahymena thermophila_SB210@REF_XP_001470832[2][RRM1:50%][.RRM2:50%][put-sr:50%][KOG0120:100%]Piroplasmida@SMA_Q4N3F2_THEPA[5][RRM2:60%*][.RRM1:40%][KOG0120:100%*]
Plasmodium@PRO_XP_001348830[10][RRM2:60%*][.RRM1:40%*][put-sr:40%*][KOG0120:100%**]Eukaryota@PRO_jgi_Volca1_82970[198][RRM2:88%*****][.RRM1:12%***][put-sr:82%*****][snRNP:51%****][KOG0120:100%*****]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_11145[RRM2][KOG0120]Oligohymenophorea@REF_XP_001028025[6][RRM1:100%*][KOG0120:100%*]
Dictyostelium_discoideum@PRO_XP_642758[4][RRM1:100%*]Dictyostelium discoideum_AX4@PRO_XP_641568[3][RRM3:67%][.RRM2:33%][KOG3598:100%*]
Nematostella vectensis@REF_XP_001638999[RRM3][KOG0144]Eukaryota@PRO_jgi_Volca1_104604[103][RRM1:100%****][put-sr:80%****][KOG0151:100%****]
Filobasidiella_neoformans@SMA_Q55R42_CRYNE[5][RRM1:100%*][put-sr:100%*][KOG0151:100%*]Plasmodium@REF_XP_672919[11][RRM1:100%**][KOG0151:100%**]
Pichia guilliermondii_ATCC_6260@REF_XP_001486325[RRM1][put-sr][KOG0148]Saccharomycetales@PRO_XP_454345[13][RRM1:100%**][KOG0148:77%**][.KOG0123:23%*]
Saccharomycetales@PRO_XP_001383142[8][RRM1:100%**][put-sr:100%**][KOG0148:100%**]Yarrowia lipolytica@PRO_XP_501542[3][RRM1:100%*][KOG0131:100%*]
Filobasidiella_neoformans@PRO_XP_570577[4][RRM1:100%*][KOG0148:100%*]Pezizomycotina@REF_XP_658695[19][RRM1:100%**][KOG0148:100%**]
Encephalitozoon_cuniculi@PRO_NP_584552[3][RRM1:100%*][KOG0123:100%*]Saccharomyces cerevisiae@PRO_YBR119W[RRM1]
Trichomonas vaginalis_G3@REF_XP_001328901[RRM2][KOG4206]Theileria parva_strain_Muguga@PRO_XP_764943[RRM2][KOG4206]
Tetrahymena thermophila_SB210@REF_XP_001027266[RRM2][KOG4206]Plasmodium@PRO_XP_001349796[6][RRM2:100%*][KOG4206:100%*]
Schizosaccharomyces_pombe@PRO_NP_596424[3][RRM2:100%*][KOG4206:100%*]Pezizomycotina@SMA_Q5BH71_EMENI[9][RRM2:100%**][put-sr:33%*][KOG4206:89%**][.KOG1943:11%]
Eukaryota@PRO_ENSGACP00000013006[198][RRM2:95%*****][.RRM1:5%**][snRNP:35%****][KOG4206:100%*****]Cryptococcus_neoformans_var._neoformans@PRO_XP_568533_RRM
Caenorhabditis@SMA_Q21322_CAEEL[2][RRM2:100%][KOG4206:100%]Caenorhabditis@SMA_Q61A17_CAEBR[2][RRM2:100%][KOG4206:100%]
Entamoeba histolytica_HM-1_IMSS@REF_XP_655803[2][RRM1:100%][KOG0148:100%]Trichomonas vaginalis_G3@REF_XP_001318438[RRM1]
Trichomonas vaginalis_G3@REF_XP_001317501[RRM1]Saccharomyces cerevisiae@PRO_YOR319W[2][RRM2:100%][KOG0131:100%]
Plasmodium@REF_XP_742863[2][RRM1:100%]Trichomonas vaginalis_G3@REF_XP_001312327[RRM2][KOG0123]
41 - snRNP
13
64 - snRNP
38 - cyclophilin
36 - snRNP
59
part of 39
Fig. S9
120
83 78
52
52
71
83
93
54
61
71
67
75 52
57
61
Dictyostelium discoideum AX4@PRO XP 638262[3][RRM2:100%*][put sr:100%*][KOG0670:100%*]Cryptosporidium@PRO_XP_628096[5][RRM2:100%*][put-sr:100%*][KOG0124:100%*]Eumetazoa@PRO_ENSCSAVP00000007991[136][RRM2:97%****][UMH:82%****][KOG0124:100%****]
Phytophthora@PRO_jgi_Phyra1_1_84640[3][RRM2:67%][.RRM1:33%][KOG0124:67%][.KOG0120:33%]Dictyostelium discoideum_AX4@PRO_XP_638262[3][RRM1:100%*][put-sr:100%*][KOG0670:100%*]
Eumetazoa@PRO_Y47G6A_20a[142][RRM1:100%****][UMH:81%****][KOG0124:100%****]Theileria@SMA_Q4U9D6_THEAN[4][RRM1:100%*][put-sr:100%*][KOG0124:100%*]
Cryptosporidium@PRO_XP_628096[5][RRM1:100%*][put-sr:100%*][KOG0124:100%*]Phytophthora ramorum@PRO_jgi_Phyra1_1_81440[2][RRM1:100%][KOG0124:100%]
Phytophthora@PRO_jgi_Phyra1_1_94266[2][RRM2:100%][KOG0147:100%]Cryptococcus_neoformans_var._neoformans@PRO_XP_571060_RRM
Cicer arietinum@SMA_Q9FT01_CICAR[RRM2][KOG0147]Yarrowia lipolytica@PRO_XP_504318[3][RRM2:100%*][KOG0147:100%*]
Volvox carteri@PRO_jgi_Volca1_106063[RRM2]Dictyostelium discoideum_AX4@SMA_Q54HN5_DICDI[3][RRM3:100%*][KOG3598:100%*]
Nematostella vectensis@REF_XP_001635913[RRM3][KOG0144]Arabidopsis thaliana@SMA_Q9LYN7_ARATH[RRM2][KOG4660]
Embryophyta@PRO_IMGA_AC141435_12_2[42][RRM2:79%***][.RRM1:21%**][KOG4660:100%***]Entamoeba histolytica_HM-1_IMSS@REF_XP_652879[2][RRM2:100%][KOG4660:100%]
Entamoeba histolytica_HM-1_IMSS@SMA_Q50LX7_ENTHI[2][RRM1:100%][KOG4660:100%]Entamoeba histolytica_HM-1_IMSS@REF_XP_655248[4][RRM1:50%][.RRM2:50%][KOG4660:100%*]
Coelomata@SMA_Q80VS9_MOUSE[12][RRM2:67%**][.RRM1:33%*][RBM:67%**]Amniota@PRO_ENSMODP00000002817[15][RRM1:100%**]Pezizomycotina@PRO_XP_962704[12][RRM1:100%**][put-sr:17%][KOG4206:100%**]
Debaryomyces hansenii@SMA_Q6BW78_DEBHA[RRM1][KOG4206]Pichia stipitis_CBS_6054@PRO_XP_001382592[RRM1][KOG4206]
Entamoeba histolytica_HM-1_IMSS@SMA_Q51EE9_ENTHI[RRM1][KOG4206]Candida albicans_SC5314@SMA_Q5A4F9_CANAL[RRM1][KOG4206]Schizosaccharomyces pombe@SMA_O74968_SCHPO[RRM1][KOG4206]
Theileria annulata@SMA_Q4UD23_THEAN[RRM1][KOG4206]Plasmodium falciparum_3D7@SMA_Q8IEP6_PLAF7[RRM1][KOG4206]
Ascomycota@SMA_RU2B_SCHPO[4][RRM1:100%*][KOG4206:100%*]Yarrowia lipolytica@SMA_Q6C824_YARLI[RRM1][KOG4206]
root@SMA_UPI00005145B2[100][RRM1:100%****][snRNP:54%***][KOG4206:100%****]Schistosoma japonicum@SMA_Q5DD61_SCHJA[RRM1][KOG4206]
Tetrahymena thermophila_SB210@REF_XP_001027266[2][RRM1:100%][KOG4206:100%]Plasmodium@SMA_Q7RQA6_PLAYO[4][RRM1:100%*][KOG4206:100%*]
Theileria@PRO_XP_764943[5][RRM1:100%*][KOG4206:100%*]Tetrahymena thermophila_SB210@SMA_Q22CK3_TETTH[RRM1][KOG4206]
Kluyveromyces lactis@SMA_Q6CVJ3_KLULA[RRM1][KOG4206]Saccharomyces cerevisiae@SMA_MSL1_YEAST[RRM1][KOG4206]
Nematostella vectensis@REF_XP_001624470[RRM1]Gallus gallus@PRO_ENSGALP00000012472[3][RRM1:100%*][KOG0123:100%*]
Euteleostomi@PRO_ENSGACP00000011877[11][RRM1:100%**][nucleolin:27%*][KOG0123:100%**]Trichomonas vaginalis_G3@REF_XP_001315258[RRM1][KOG0116]
Sclerotiniaceae@REF_XP_001591252[2][RRM1:100%][KOG0148:100%]Coccidioides immitis_RS@REF_XP_001244865[RRM1][KOG0110]
Trichocomaceae@REF_XP_001213939[9][RRM1:100%**][KOG0110:100%**]Trichomonas vaginalis_G3@REF_XP_001314467[2][RRM1:100%][KOG0108:100%]
Eurotiomycetidae@REF_XP_001246170[12][RRM3:100%**][KOG0128:100%**]Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_27365[2][RRM2:100%][KOG0123:100%]
Trichomonas vaginalis_G3@REF_XP_001319048[RRM1]Entamoeba histolytica_HM-1_IMSS@SMA_Q50UR4_ENTHI[3][RRM1:100%*][KOG0127:100%*]
Entamoeba histolytica_HM-1_IMSS@SMA_Q50Q51_ENTHI[2][RRM1:100%][KOG0123:100%]Trichomonas vaginalis_G3@REF_XP_001304682[RRM1]
Trichomonas vaginalis_G3@REF_XP_001319448[RRM1][KOG0148]Trichomonas vaginalis_G3@REF_XP_001329123[RRM1]
cellular_organisms@REF_XP_657084[3][RRM1:100%*][PROK:33%][KOG0148:67%][.KOG0149:33%]Entamoeba histolytica_HM-1_IMSS@REF_XP_652707[2][RRM1:100%][put-sr:100%][KOG0117:100%]
Ustilago maydis_521@PRO_XP_761797[3][RRM2:100%*][put-sr:100%*][KOG3257:100%*]Trichomonas vaginalis_G3@REF_XP_001295319[RRM1]
Nematostella vectensis@REF_XP_001630508[RRM2][KOG1015]Trichomonas_vaginalis@REF_XP_001323895[2][RRM1:100%][KOG4205:50%][.KOG0149:50%]
Trichomonas vaginalis_G3@REF_XP_001315624[RRM1][KOG0149]Trichomonas vaginalis_G3@REF_XP_001308576[RRM1]
Trichomonas vaginalis_G3@REF_XP_001327731[RRM1]Yarrowia lipolytica@SMA_Q6CG61_YARLI[3][RRM2:100%*][KOG0123:100%*]
Tetraodontidae@SMA_Q4SP55_TETNG[2][RRM3:50%][.RRM2:50%][KOG0123:50%]Euteleostomi@PRO_ENSGALP00000012472[89][RRM4:89%****][.RRM2:7%*][nucleolin:62%****][KOG0123:99%****]
Nectria haematococca@SMA_Q00880_NECHA[RRM1][KOG0148]Pezizomycotina@REF_XP_001585064[13][RRM1:100%**][KOG0148:100%**]
Sordariomycetes@REF_XP_363342[7][RRM1:100%*][KOG0148:57%*][.KOG0127:43%*]Dikarya@PRO_XP_566835[36][RRM1:100%***][nucleolin:17%*][KOG0148:69%***][.KOG0131:17%*][.KOG0147:8%*][.KOG4210:6%]
Trichomonas vaginalis_G3@REF_XP_001323074[RRM1]Dictyostelium discoideum_AX4@PRO_XP_641373[3][RRM1:100%*][put-sr:100%*]
Paramecium tetraurelia@REF_XP_001427555[4][RRM1:100%*][KOG0107:25%]Phytophthora@PRO_jgi_Physo1_1_140403[2][RRM1:100%][put-sr:100%][KOG0127:100%]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_10122[RRM1][KOG0153]Paramecium tetraurelia@REF_XP_001458086[RRM1][put-sr]
Tetrahymena thermophila_SB210@SMA_Q246W1_TETTH[RRM1][put-sr]Dictyostelium discoideum_AX4@PRO_XP_639372[3][RRM1:100%*][KOG0670:100%*]
Tetrapoda@SMA_CPSF6_MOUSE[19][RRM1:100%**][put-sr:95%**][KOG4849:100%**]Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_26750[2][RRM1:100%]
Oryza sativa@SMA_Q7XJW3_ORYSA[RRM1][put-sr]Embryophyta@SMA_Q6ZBP8_ORYSA[16][RRM1:100%**][put-sr:69%**][KOG4849:31%*][.KOG4246:19%*][.KOG4676:19%*][.KOG0113:6%]
Embryophyta@SMA_Q9SX79_ARATH[45][RRM1:100%***][oligoU:16%*][KOG0148:98%***]Tetrahymena thermophila_SB210@REF_XP_001022345[RRM1][KOG0148]
Euteleostomi@REF_XP_865602[9][RRM1:100%**][KOG0131:56%*][.KOG0123:22%]Bilateria@PRO_XP_974444[8][RRM1:100%**][KOG0144:62%*][.KOG0123:25%]Schizosaccharomyces pombe@SMA_YG41_SCHPO[RRM1][KOG0148]
Aspergillus fumigatus@SMA_Q4WAR5_ASPFU[RRM1][KOG0148]rosids@PRO_NP_200794[10][RRM1:100%**][oligoU:70%*][KOG0113:30%*][.KOG0122:30%*][.KOG0148:10%]
Magnoliophyta@PRO_29930_m000611[11][RRM1:100%**][KOG0113:100%**]Magnoliophyta@PRO_9946_m000021_AZM5_3995[4][RRM1:100%*][KOG0113:75%*][.KOG0111:25%]Magnoliophyta@PRO_NP_001052753[7][RRM1:100%*][oligoU:43%*][KOG0108:43%*][.KOG0149:43%*][.KOG0127:14%]
Giardia lamblia_ATCC_50803@REF_XP_001706513[2][RRM2:100%][KOG0110:100%]Ricinus communis@PRO_30055_m001598[RRM1][KOG0149]
Arabidopsis thaliana@PRO_NP_565646[3][RRM1:100%*][KOG0149:100%*]Medicago truncatula@SMA_Q1T5G5_MEDTR[2][RRM1:100%][KOG0149:100%]
Oryza sativa_japonica_cultivar-group@PRO_NP_001045556[3][RRM1:100%*][KOG0108:67%][.KOG0113:33%]Entamoeba histolytica_HM-1_IMSS@REF_XP_651783[2][RRM1:100%][KOG0123:100%]
Paramecium tetraurelia@REF_XP_001436649[2][RRM1:100%][KOG0123:100%]Cyanidioschyzon merolae@PRO_gnl_CMER_CMG025C[RRM1][KOG1080]
Trichomonas vaginalis_G3@REF_XP_001329617[RRM1][put-sr]Plasmodium@REF_XP_001615651[10][RRM2:100%**][KOG0147:100%**]
Babesia bovis@REF_XP_001611287[RRM2][put-sr][KOG0147]Theileria@REF_XP_762815[4][RRM2:100%*][put-sr:100%*][KOG0147:100%*]
Ciona intestinalis@PRO_ENSCINP00000019833[3][RRM2:100%*][KOG0128:100%*]Eumetazoa@SMA_ENSDARP00000051594[63][RRM2:98%****][SART3:75%***][KOG0128:100%****]
Culicidae@PRO_AAEL011963-PA[8][RRM2:100%**][KOG0128:100%**]Strongylocentrotus purpuratus@SMA_UPI0000584378[3][RRM2:100%*][KOG0128:100%*]
Tribolium castaneum@PRO_XP_972538[3][RRM2:100%*][KOG0128:100%*]Apocrita@PRO_XP_001602582[5][RRM2:100%*][KOG0128:100%*]
Schistosoma japonicum@SMA_Q5DH08_SCHJA[RRM1][KOG0123]Ascomycota@SMA_Q6C1Y4_YARLI[28][RRM1:96%***][KOG1457:14%*][.KOG3598:7%]
Dictyostelium discoideum_AX4@PRO_XP_629950[3][RRM1:100%*][KOG0128:100%*]Candida albicans_SC5314@SMA_Q5A422_CANAL[RRM1]
Trichomonas vaginalis_G3@REF_XP_001312066[RRM1]Yarrowia lipolytica@PRO_XP_499736[3][RRM2:67%][.RRM1:33%][KOG4205:100%*]
Schizosaccharomyces_pombe@PRO_NP_594970[3][RRM2:100%*][KOG4210:100%*]
37 - SART3
40 - snRNP
43
67 - UMH
part of 39
Fig. S9
121
96
62
67
96
100
56
69
61
Trichomonas vaginalis G3@REF XP 001313255[RRM1][KOG0123]Trichomonas vaginalis_G3@REF_XP_001314386[2][RRM1:100%][KOG0123:100%]
Strongylocentrotus purpuratus@PRO_XP_001185731[4][RRM1:100%*]Endopterygota@SMA_NELFE_DROVI[8][RRM1:100%**]
Yarrowia lipolytica@PRO_XP_503462[3][RRM1:100%*][put-sr:100%*][KOG0130:100%*]Filobasidiella_neoformans@PRO_XP_569809[5][RRM1:100%*][KOG0130:100%*]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_20716[RRM1][KOG0130]Babesia bovis@REF_XP_001611322[RRM1][KOG0130]
Eukaryota@REF_XP_001462151[152][RRM1:100%*****][put-sr:58%****][RBM:35%***][KOG0130:98%*****]Plasmodium_yoelii_yoelii@REF_XP_724364[2][RRM1:100%][KOG0130:100%]
Plasmodium@REF_XP_001616889[4][RRM1:100%*][KOG0130:100%*]Schistosoma japonicum@SMA_Q5DH48_SCHJA[RRM2][KOG4205]Trichomonas vaginalis_G3@REF_XP_001321938[3][RRM1:100%*][KOG0111:100%*]
Cryptococcus_neoformans_var._neoformans@PRO_XP_566572_RRMOrnithorhynchus anatinus@PRO_ENSOANP00000022523[3][RRM1:67%][.RRM2:33%][KOG2248:100%*]
Paramecium tetraurelia@REF_XP_001461630[2][RRM1:100%][KOG0111:100%]Schizosaccharomyces_pombe@PRO_NP_595190[3][RRM1:100%*][KOG0111:100%*]
Theileria@SMA_Q4UGS2_THEAN[5][RRM1:100%*][KOG0111:100%*]Babesia bovis@REF_XP_001610344[RRM1][KOG0111]
Entamoeba histolytica_HM-1_IMSS@REF_XP_656069[2][RRM1:100%][KOG0111:100%]Plasmodium@PRO_XP_001349948[8][RRM1:100%**][KOG0111:100%**]
Thalassiosira pseudonana@PRO_jgi_Thaps3_31121[RRM1][KOG0111]Phaeodactylum tricornutum@PRO_jgi_Phatr2_11308[RRM1][KOG0111]
Eukaryota@SMA_Q4G338_HAECO[134][RRM1:100%****][cyclophilin:66%****][KOG0111:98%****]Pezizomycotina@PRO_XP_755630[23][RRM1:100%***][KOG0111:100%***]
Apis mellifera@SMA_UPI00005132BD[RRM1][cyclophilin][KOG0111]Eutheria@PRO_ENSEEUP00000009324[3][RRM1:100%*][cyclophilin:100%*][KOG0111:100%*]Otolemur garnettii@PRO_ENSOGAP00000003225[RRM1][KOG0111]Caenorhabditis@REF_XP_001671871[8][RRM2:100%**][put-sr:62%*][UMH:100%**][KOG0147:100%**]
Euteleostomi@SMA_ENSBTAP00000008515[11][RRM2:91%**][.RRM1:9%][put-sr:82%**][RBM:9%][KOG0112:100%**]Anopheles gambiae@SMA_ENSANGP00000011942[RRM1][KOG0880]
Caenorhabditis briggsae@REF_XP_001680458[RRM1][KOG0105]Cryptosporidium_parvum@PRO_XP_627232[3][RRM1:100%*][put-sr:100%*][KOG0105:100%*]
Tetrahymena thermophila_SB210@REF_XP_001012866[2][RRM2:100%][put-sr:100%][KOG0117:100%]Tetrahymena thermophila_SB210@REF_XP_001012866[2][RRM3:100%][put-sr:100%][KOG0117:100%]
Saccharomyces cerevisiae@PRO_YLL046C[3][RRM1:100%*]Plasmodium@REF_XP_001617331[10][RRM3:100%**][KOG0123:100%**]
Theileria@SMA_Q4N775_THEPA[5][RRM3:100%*][KOG0123:100%*]Babesia bovis@REF_XP_001610750[RRM3][KOG0123]
Cryptosporidium@SMA_Q5CLX5_CRYHO[5][RRM3:100%*][KOG0123:100%*]Dictyostelium discoideum_AX4@PRO_XP_645848[3][RRM1:100%*][put-sr:100%*]
Encephalitozoon cuniculi@SMA_Q8SR30_ENCCU[RRM4][put-sr][KOG0123]Entamoeba histolytica_HM-1_IMSS@REF_XP_648918[2][RRM2:100%][KOG0148:100%]
Entamoeba histolytica_HM-1_IMSS@SMA_Q51CH0_ENTHI[RRM1][KOG0144]Entamoeba histolytica_HM-1_IMSS@SMA_Q511G4_ENTHI[RRM2][KOG0148]
Aconoidasida@REF_XP_001613785[16][RRM1:100%**][put-sr:88%**][KOG0105:100%**]Tetrahymena thermophila_SB210@REF_XP_001023381[RRM1][put-sr]
Sclerotiniaceae@REF_XP_001594190[2][RRM2:100%][put-sr:100%][KOG0123:100%]Theileria@REF_XP_953908[5][RRM1:100%*][put-sr:100%*][KOG0105:100%*]
Plasmodium@PRO_XP_001347876[4][RRM1:100%*][KOG0105:100%*]Toxoplasma gondii@SMA_Q6GYB0_TOXGO[RRM1][put-sr][KOG0105]
Eukaryota@PRO_ENSTBEP00000007356[224][RRM1:100%*****][put-sr:83%*****][SR:73%*****][KOG0105:100%*****]Eutheria@REF_XP_001160597[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%]
Caenorhabditis briggsae@REF_XP_001676750[2][RRM1:100%][KOG0107:100%]Theileria@REF_XP_954918[3][RRM1:100%*][put-sr:67%][KOG0107:33%]
Bigelowiella natans@SMA_Q5YES7_CHLS6[RRM1][put-sr]Yarrowia lipolytica@PRO_XP_505724[2][RRM1:100%][KOG4198:100%]
Endopterygota@PRO_CG5655-PA[19][RRM1:100%**][put-sr:89%**][KOG0107:79%**][.KOG0921:16%*]Strongylocentrotus purpuratus@PRO_XP_001178467[5][RRM1:100%*][put-sr:100%*]
Eukaryota@SMA_UPI0000D68409[351][RRM1:100%*****][put-sr:74%*****][SR:61%*****][KOG0107:69%*****]Schistosoma japonicum@SMA_Q5DD33_SCHJA[2][RRM1:100%][put-sr:50%][KOG0107:50%]
Bilateria@PRO_XP_001180596[7][RRM1:100%*][put-sr:71%*][KOG0107:14%]Phytophthora@PRO_jgi_Physo1_1_138982[2][RRM1:100%][KOG0105:100%]
Trichomonas vaginalis_G3@REF_XP_001299622[2][RRM1:100%]Eremothecium gossypii@SMA_Q756B8_ASHGO[RRM1]
Dikarya@PRO_NP_596398[10][RRM1:100%**][put-sr:70%*][SR:30%*]Yarrowia lipolytica@PRO_XP_500797[2][RRM1:100%][put-sr:100%]
Embryophyta@PRO_NP_194280[27][RRM1:100%***][put-sr:89%***][SR:74%**][KOG0106:100%***]Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_8794[2][RRM1:100%][KOG0105:100%]
Dictyostelium discoideum_AX4@PRO_XP_638672[3][RRM1:100%*][put-sr:100%*][KOG0147:100%*]Dictyostelium_discoideum@PRO_XP_001134500[4][RRM1:100%*][put-sr:100%*][KOG0147:100%*]
Strongylocentrotus purpuratus@SMA_UPI0000587C32[6][RRM1:100%*][KOG0107:83%*]Nematostella vectensis@REF_XP_001641195[RRM1][put-sr][KOG0109]
Nematostella vectensis@REF_XP_001623720[RRM1][put-sr][KOG0106]Ciona intestinalis@PRO_ENSCINP00000016525[RRM1][put-sr][KOG0106]
Caenorhabditis@REF_XP_001679560[11][RRM1:100%**][put-sr:100%**][SR:100%**][KOG0106:100%**]Cavia porcellus@PRO_ENSCPOP00000010577[RRM1][put-sr][SR][KOG0106]
Aedes aegypti@PRO_AAEL012621-PA[2][RRM1:100%][put-sr:100%][KOG0105:100%]Eukaryota@PRO_ENSOANP00000021053[343][RRM1:100%*****][put-sr:83%*****][SR:65%*****][KOG0106:57%*****][.KOG0105:36%****]
Filobasidiella_neoformans@PRO_XP_567562[4][RRM1:100%*][KOG0106:100%*]Schizosaccharomyces_pombe@PRO_NP_594570[3][RRM1:100%*][put-sr:100%*][KOG0106:100%*]
Pezizomycotina@PRO_XP_960334[15][RRM1:100%**][put-sr:87%**][KOG0105:53%**][.KOG0106:47%*]Entamoeba histolytica_HM-1_IMSS@REF_XP_656450[2][RRM1:100%]
Thalassiosira pseudonana@PRO_jgi_Thaps3_2206[RRM1]Dictyostelium discoideum_AX4@PRO_XP_638966[3][RRM2:100%*][KOG0147:100%*]
Dictyostelium discoideum_AX4@PRO_XP_643007[3][RRM1:100%*]Paramecium tetraurelia@REF_XP_001426030[RRM2][put-sr][KOG0148]
Tetrahymena thermophila_SB210@REF_XP_001024078[2][RRM1:100%]Tetrahymena thermophila_SB210@SMA_Q247H9_TETTH[2][RRM1:50%][.RRM2:50%][KOG1190:100%]Tetrahymena thermophila_SB210@SMA_Q22GW9_TETTH[RRM1][KOG1190]
Babesia bovis@REF_XP_001610592[RRM1][KOG0123]Theileria@SMA_Q4UJ52_THEAN[5][RRM1:100%*][KOG0124:100%*]
Aedes aegypti@PRO_AAEL010890-PA[2][RRM1:100%][put-sr:100%][KOG0132:100%]Trichomonas vaginalis_G3@REF_XP_001305138[RRM1]
Tetrahymena thermophila_SB210@REF_XP_001020597[2][RRM1:100%][put-sr:50%][KOG0107:50%][.KOG0109:50%]Plasmodium@SMA_Q4YSH6_PLABE[10][RRM1:100%**][put-sr:80%**][KOG0105:100%**]
Dictyostelium discoideum_AX4@PRO_XP_645848[3][RRM2:100%*][put-sr:100%*]Trichomonas vaginalis_G3@REF_XP_001312176[RRM1]
Paramecium tetraurelia@REF_XP_001450678[RRM1]Paramecium tetraurelia@REF_XP_001442708[4][RRM1:100%*][put-sr:100%*][KOG0105:25%]
Chlamydomonadales@PRO_jgi_Volca1_120471[2][RRM1:100%][KOG0108:100%]Trichomonas vaginalis_G3@REF_XP_001316284[RRM1]
Trichomonas vaginalis_G3@REF_XP_001326015[RRM1]Trichomonas vaginalis_G3@REF_XP_001317742[RRM1]Paramecium tetraurelia@REF_XP_001448078[2][RRM1:100%][KOG1029:50%]
Phytophthora@PRO_jgi_Physo1_1_138873[2][RRM1:100%][put-sr:100%][KOG1611:50%]Theileria@REF_XP_764360[2][RRM1:100%]
Plasmodium@REF_XP_001615424[7][RRM1:100%*]Viridiplantae@PRO_jgi_Phypa1_1_105411[16][RRM1:100%**][put-sr:100%**][SR:31%*][KOG0117:19%*][.KOG0462:6%]
Dictyostelium discoideum_AX4@PRO_XP_636445[3][RRM1:100%*][put-sr:100%*]Eumetazoa@PRO_ENSMUSP00000057332[133][RRM1:100%****][put-sr:97%****][RNPS1:64%****][KOG4209:86%****]Apis mellifera@SMA_UPI0000513642[RRM1][put-sr]Caenorhabditis@PRO_K02F3_11_2[6][RRM1:100%*][put-sr:100%*][KOG4209:67%*]
Schizosaccharomyces_pombe@PRO_NP_596549[4][RRM1:100%*][put-sr:100%*]Pezizomycotina@SMA_Q2PIY9_ASPOR[16][RRM1:100%**][put-sr:81%**][KOG0111:6%]Filobasidiella_neoformans@PRO_XP_569824[5][RRM1:100%*][put-sr:100%*]
Pan troglodytes@SMA_UPI0000494C3A[RRM1][put-sr][KOG0147]Eukaryota@PRO_ENSFCAP00000006163[253][RRM2:92%*****][.RRM1:8%***][put-sr:87%*****][UMH:28%****][.CAPER:19%***][KOG0147:100%*****]
Bacillariophyta@PRO_jgi_Phatr2_20857[2][RRM2:100%][put-sr:100%][KOG0147:100%]Dictyostelium discoideum_AX4@PRO_XP_638262[3][RRM2:100%*][put-sr:100%*][KOG0670:100%*]
2827 - RNPS1
26 - SR45
17 - single-RRM
Zc-K SR proteins
part of 16
- dual-RRM
SR proteins
18
21
19 - cyclophilin
20 - RBM
part of 16
- dual-RRM
SR proteins
Fungal SR (SpSrp2)
Fungal SR (SpSrp1)
Fungal SpRnps1Fig. S9
122
79
80
84
51
83
58
69
65
86
66
Dictyostelium discoideum AX4@PRO XP 644081[3][RRM3:100%*][KOG0123:100%*]Paramecium tetraurelia@REF_XP_001432601[2][RRM2:100%][KOG0146:100%]
Tetrahymena thermophila_SB210@SMA_Q22JW6_TETTH[4][RRM1:50%][.RRM3:50%][KOG0144:50%][.KOG0146:50%]Cryptosporidium@SMA_Q5CJX5_CRYHO[4][RRM3:100%*][put-sr:100%*][KOG0144:100%*]
Eukaryota@REF_XP_742626[566][RRM3:69%*****][.RRM2:20%****][.RRM1:10%****][Bruno:46%*****][KOG0144:51%*****][.KOG0146:49%*****]Tetrahymena thermophila_SB210@REF_XP_001023043[2][RRM3:100%][KOG0144:100%]
Plasmodium@PRO_XP_001350320[4][RRM2:75%*][.RRM1:25%][KOG0123:100%*]Plasmodium@PRO_XP_001350320[4][RRM3:75%*][.RRM2:25%][KOG0123:100%*]Aconoidasida@REF_XP_672316[30][RRM2:60%**][.RRM1:40%**][KOG0146:73%***][.KOG0144:17%*][.KOG0145:10%*]
Plasmodium yoelii_yoelii@SMA_Q7RL66_PLAYO[RRM2][KOG0146]Trichomonas vaginalis_G3@REF_XP_001302991[2][RRM4:100%][KOG0123:100%]Trichomonas vaginalis_G3@REF_XP_001303266[RRM4][KOG0123]
Caenorhabditis briggsae@REF_XP_001670970[RRM2][KOG0117]Trichomonas vaginalis_G3@REF_XP_001302992[11][RRM2:100%**][KOG0123:100%**]
Sordariomycetes@REF_XP_360527[6][RRM1:100%*][KOG0110:83%*][.KOG0123:17%]Saccharomycetaceae@PRO_NP_984845[4][RRM2:100%*][KOG0123:100%*]
Encephalitozoon_cuniculi@SMA_Q8SR30_ENCCU[3][RRM2:100%*][put-sr:100%*][KOG0123:100%*]Eukaryota@SMA_UPI0000494B5B[859][RRM2:95%******][.RRM1:5%***][PABP:44%*****][KOG0123:78%******][.KOG0131:22%*****]
Leishmania@PRO_XP_001466041[5][RRM2:100%*][KOG0123:100%*]Arabidopsis thaliana@SMA_Q9FX22_ARATH[4][RRM1:75%*][.RRM2:25%][PABP:100%*][KOG0123:100%*]
Schizosaccharomyces_pombe@PRO_NP_593427[3][RRM2:100%*][KOG0123:100%*]Schizosaccharomyces_pombe@SMA_PABPX_SCHPO[3][RRM3:100%*][KOG0123:100%*]
Oryza sativa_japonica_cultivar-group@PRO_NP_001049727[2][RRM2:100%][KOG0123:100%]rosids@PRO_30146_m003481[4][RRM2:100%*][PABP:75%*][KOG0123:100%*]
rosids@PRO_30078_m002213[5][RRM2:100%*][PABP:60%*][KOG0123:100%*]Trypanosomatidae@SMA_Q643Z0_CRIFA[11][RRM4:100%**][KOG0123:100%**]
Trypanosomatidae@SMA_Q4E4I9_TRYCR[11][RRM4:100%**][KOG0123:100%**]Oryza sativa_japonica_cultivar-group@PRO_NP_001049727[2][RRM3:100%][KOG0123:100%]
rosids@PRO_30078_m002213[5][RRM3:100%*][PABP:60%*][KOG0123:100%*]Arabidopsis thaliana@PRO_NP_195978[3][RRM1:100%*][KOG0123:100%*]
Ricinus communis@PRO_30146_m003481[RRM3][KOG0123]Dictyostelium discoideum_AX4@SMA_Q54D57_DICDI[3][RRM2:100%*][KOG0145:100%*]
Filobasidiella_neoformans@SMA_Q55XM4_CRYNE[5][RRM1:100%*][put-sr:40%][KOG0123:60%*][.KOG0148:40%]Ustilago maydis_521@SMA_Q4P9A2_USTMA[3][RRM2:100%*][KOG0123:100%*]
Dictyostelium_discoideum@PRO_XP_001134510[4][RRM4:100%*][KOG0123:100%*]Trichomonas vaginalis_G3@REF_XP_001324580[RRM2][KOG0131]
Yarrowia lipolytica@PRO_XP_503979[3][RRM2:100%*][KOG0131:100%*]Saccharomycetales@PRO_XP_001385635[11][RRM2:100%**][KOG0131:100%**]
Tetrahymena thermophila_SB210@REF_XP_001008485[2][RRM2:100%][KOG0131:100%]Bigelowiella natans@SMA_Q3LWM7_CHLS6[RRM2][KOG0131]
Cryptosporidium@SMA_Q5CWM4_CRYPV[4][RRM2:100%*][KOG0131:100%*]Dictyostelium discoideum_AX4@SMA_Q556F3_DICDI[3][RRM2:100%*][KOG0123:100%*]
Trypanosomatidae@PRO_XP_001468777[9][RRM2:100%**][KOG0144:100%**]Volvox carteri@PRO_jgi_Volca1_116517[RRM2][KOG1984]
Dictyostelium discoideum_AX4@PRO_XP_646802[3][RRM2:100%*][KOG0145:100%*]Eumetazoa@PRO_ENSTBEP00000005385[198][RRM2:90%*****][.RRM1:10%**][P54nrb:38%****][.PSF:22%***][.PSP1:20%***][KOG0115:100%*****]
Yarrowia lipolytica@SMA_Q6CG61_YARLI[3][RRM3:100%*][KOG0123:100%*]Bilateria@SMA_Q5U586_XENLA[4][RRM3:100%*][KOG0123:100%*]
Leishmania@PRO_XP_001466041[5][RRM4:100%*][KOG0123:100%*]Sophophora@SMA_Q28WW6_DROPS[5][RRM2:100%*][KOG0123:100%*]
Pezizomycotina@SMA_Q5B630_EMENI[15][RRM4:100%**][KOG0123:100%**]Arabidopsis thaliana@SMA_O04319_ARATH[3][RRM4:100%*][PABP:100%*][KOG0123:100%*]
Aedes aegypti@PRO_AAEL007013-PA[2][RRM1:100%][KOG0123:100%]Oryza_sativa@SMA_Q259G3_ORYSA[4][RRM3:100%*][KOG0123:100%*]
Oikopleura dioica@SMA_Q6E7B9_OIKDI[RRM4][KOG0123]Canis familiaris@SMA_UPI00005A28E0[2][RRM4:100%][PABP:100%][KOG0123:100%]Pan troglodytes@SMA_UPI0000494B5B[RRM4][KOG0123]
Trypanosomatidae@SMA_O96971_9TRYP[11][RRM3:100%**][KOG0123:100%**]Echinops telfairi@PRO_ENSETEP00000008100[RRM3][PABP][KOG0123]
Rattus norvegicus@REF_XP_001070732[RRM1][KOG0123]Eukaryota@REF_XP_001154366[1189][RRM4:46%******][.RRM3:45%******][.RRM2:6%****][PABP:61%******][KOG0123:100%*******]
Encephalitozoon cuniculi_GB-M1@PRO_NP_586099[RRM2][KOG0131]Felis catus@PRO_ENSFCAP00000004622[RRM3][PABP][KOG0123]
Trypanosomatidae@SMA_Q4E4I9_TRYCR[5][RRM3:100%*][KOG0123:100%*]Trichomonas vaginalis_G3@REF_XP_001303266[RRM3][KOG0123]
Dikarya@REF_XP_001560741[58][RRM3:100%****][PABP:10%*][KOG0123:100%****]Yarrowia lipolytica@SMA_Q6CDH3_YARLI[3][RRM3:100%*][KOG0123:100%*]
Strongylocentrotus purpuratus@REF_NP_001091917[7][RRM3:71%*][.RRM2:29%][KOG0123:100%*]Dictyostelium discoideum_AX4@SMA_Q54BM2_DICDI[3][RRM3:100%*][KOG0123:100%*]
Chlamydomonadales@PRO_jgi_Volca1_82578[3][RRM3:100%*][PABP:100%*][KOG0123:100%*]Oikopleura dioica@SMA_Q6E7B9_OIKDI[RRM3][KOG0123]
Thalassiosira pseudonana@PRO_jgi_Thaps3_13224[RRM3][KOG0123]Phytophthora@PRO_jgi_Physo1_1_108322[2][RRM3:100%][KOG0123:100%]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_23959[RRM3][KOG0123]Strongylocentrotus purpuratus@SMA_UPI0000584A56[5][RRM1:100%*][KOG0117:80%*][.KOG0122:20%]
Trypanosomatidae@REF_XP_001568515[11][RRM2:100%**][KOG0123:100%**]Entamoeba histolytica_HM-1_IMSS@SMA_Q50S75_ENTHI[RRM1][KOG0123]
Entamoeba histolytica_HM-1_IMSS@REF_XP_649839[2][RRM2:100%][KOG0123:100%]Trypanosomatidae@SMA_Q4D576_TRYCR[5][RRM1:100%*][KOG0144:100%*]
Oryza sativa_japonica_cultivar-group@SMA_Q7EY44_ORYSA[RRM2][KOG0117]Embryophyta@PRO_jgi_Phypa1_1_140180[10][RRM2:50%*][.RRM3:40%*][.RRM1:10%][KOG0117:100%**]
Oryza sativa_japonica_cultivar-group@SMA_Q6ZLD1_ORYSA[RRM3][KOG0117]Entamoeba_histolytica@REF_XP_655058[3][RRM1:100%*][KOG0110:67%][.KOG0123:33%]
Schizosaccharomyces_pombe@PRO_NP_595599[2][RRM1:100%][KOG0110:100%]Plasmodium@SMA_Q4X692_PLACH[10][RRM1:90%**][.RRM2:10%]
Kluyveromyces lactis@SMA_MRD1_KLULA[RRM1][KOG0110]Saccharomycetales@SMA_MRD1_ASHGO[3][RRM1:100%*][KOG0110:100%*]
Dictyostelium discoideum_AX4@PRO_XP_638463[3][RRM1:100%*][KOG0110:100%*]Cryptosporidium@SMA_Q5CMP8_CRYHO[2][RRM1:100%][KOG0110:100%]
Trichomonas vaginalis_G3@REF_XP_001324476[RRM1][KOG0110]Trichocomaceae@SMA_MRD1_ASPFU[3][RRM1:100%*][KOG0110:100%*]
Pezizomycotina@SMA_UPI000021AFC7[6][RRM1:100%*][KOG0110:100%*]Viridiplantae@PRO_jgi_Phypa1_1_207810[5][RRM1:100%*][KOG0110:100%*]
Cyanidioschyzon merolae@PRO_gnl_CMER_CMO246C[RRM1][KOG0110]Saccharomycetales@PRO_XP_001386803[11][RRM1:100%**][KOG0110:100%**]
Ustilago_maydis@PRO_XP_758493[3][RRM1:100%*][KOG0110:100%*]Arabidopsis thaliana@PRO_NP_196191[5][RRM1:100%*][KOG0110:100%*]
Encephalitozoon_cuniculi@PRO_NP_597181[2][RRM1:100%][KOG0110:100%]Drosophila melanogaster@PRO_CG3335-PA[3][RRM1:100%*][KOG0110:100%*]
Apocrita@PRO_XP_624611[8][RRM1:100%**][KOG0110:100%**]Oligohymenophorea@REF_XP_001454919[3][RRM1:100%*][KOG0110:100%*]
Chironomus tentans@SMA_Q95ZH1_CHITE[RRM1][KOG0110]Caenorhabditis@PRO_T23F6_4_1[6][RRM1:100%*][KOG0110:100%*]
Culicidae@PRO_AGAP005249-PA[6][RRM1:100%*][KOG0110:100%*]Euteleostomi@PRO_GSTENP00029551001[53][RRM1:100%***][put-sr:9%*][KOG0110:100%***]
Rattus norvegicus@SMA_UPI0000507A4B[RRM1][KOG0110]Entamoeba histolytica_HM-1_IMSS@SMA_Q50XW2_ENTHI[RRM1][put-sr]
Entamoeba histolytica_HM-1_IMSS@REF_XP_649199[2][RRM1:100%][put-sr:100%]Bombyx mori@REF_NP_001037313[2][RRM1:100%][KOG4365:100%]
Nasonia vitripennis@PRO_XP_001604488[2][RRM1:100%]Gallus gallus@SMA_UPI0000448E6E[2][RRM1:100%][KOG4365:100%]
Encephalitozoon_cuniculi@SMA_Q8SR30_ENCCU[3][RRM1:100%*][put-sr:100%*][KOG0123:100%*]Apis mellifera@SMA_UPI0000519A16[RRM1][KOG4341]
Trichomonas vaginalis_G3@REF_XP_001300794[RRM1]Trichomonas vaginalis_G3@REF_XP_001328309[3][RRM1:100%*][KOG0123:100%*]
Trichomonas vaginalis_G3@REF_XP_001303266[RRM1][KOG0123]Trichomonas vaginalis_G3@REF_XP_001309092[RRM1][KOG0123]
Trichomonas vaginalis_G3@REF_XP_001301635[RRM1][KOG0123]Trichomonas vaginalis_G3@REF_XP_001307992[RRM1][KOG0123]
Trichomonas vaginalis_G3@REF_XP_001313255[RRM1][KOG0123]
1
5 - PABP
6 - PABP
4 - PABP
p54nrb
PSP1
PSF
includes 67 - UMH
9 - Bruno
Fig. S9
123
57
78
96
80
78
88 68
68
90
87
67 56
89
Oryza sativa japonica cultivar group@SMA Q6ZLD1 ORYSA[RRM1][KOG0117]Trichomonas vaginalis_G3@REF_XP_001300116[RRM1]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_44468[RRM1]Thalassiosira pseudonana@PRO_jgi_Thaps3_20887[RRM1]
Plasmodium@PRO_XP_966276[8][RRM1:50%*][.RRM2:50%*][KOG0117:38%*][.KOG0148:12%]Tribolium castaneum@SMA_UPI0000D5702C[RRM1][put-sr]
Paramecium tetraurelia@REF_XP_001459353[4][RRM2:100%*][KOG0123:100%*]Paramecium tetraurelia@REF_XP_001425411[RRM2][KOG0123]
Nematostella vectensis@REF_XP_001628761[RRM1]Tribolium castaneum@PRO_XP_969873[3][RRM1:100%*]
Apocrita@PRO_XP_001604373[7][RRM1:100%*]Strongylocentrotus purpuratus@PRO_XP_001185821[5][RRM1:100%*][KOG0670:80%*]
Euteleostomi@SMA_UPI0000548A84[3][RRM1:100%*][put-sr:33%][KOG0670:33%]Caenorhabditis briggsae@SMA_Q61CW8_CAEBR[RRM1]
Strongylocentrotus purpuratus@REF_XP_001176395[3][RRM1:100%*]Drosophila melanogaster@REF_NP_996010[2][RRM1:100%][KOG0107:100%]
Euteleostomi@PRO_ENSOANP00000024755[315][RRM1:100%*****][hnRNP:53%*****][.RALYL:13%***]Tetrahymena thermophila_SB210@REF_XP_001022345[2][RRM1:50%][.RRM2:50%][KOG0148:50%]
Encephalitozoon_cuniculi@PRO_NP_585962[3][RRM2:100%*][KOG0123:100%*]Aureococcus anophagefferens@PRO_jgi_Auran1_67810[RRM1][put-sr][KOG0120]
Aureococcus anophagefferens@PRO_jgi_Auran1_66158[RRM1][put-sr][KOG0149]Nematostella vectensis@REF_XP_001640397[RRM1][KOG0111]Theileria@SMA_Q4N1I8_THEPA[4][RRM1:100%*][KOG0151:100%*]
rosids@PRO_NP_568388[5][RRM1:100%*][KOG0148:60%*][.KOG0125:20%]Physcomitrella patens@PRO_jgi_Phypa1_1_151460[4][RRM1:100%*][KOG0108:75%*][.KOG0149:25%]
Chlamydomonas reinhardtii@PRO_jgi_Chlre3_194261[RRM1][KOG0123]Aureococcus anophagefferens@PRO_jgi_Auran1_17171[RRM1][KOG0108]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_33658[RRM1]Thalassiosira pseudonana@PRO_jgi_Thaps3_263845[RRM1][KOG0108]
Anopheles_gambiae@PRO_AGAP000921-PA[9][RRM1:100%**]Ustilago maydis_521@PRO_XP_757329[3][RRM1:100%*][KOG0145:100%*]
Entamoeba histolytica_HM-1_IMSS@REF_XP_649094[2][RRM1:100%][KOG0148:100%]Nematostella vectensis@REF_XP_001624592[RRM1][KOG0148]
Bilateria@PRO_ENSSARP00000011721[211][RRM1:100%*****][TIATIAR:80%*****][KOG0148:100%*****]Oryza_sativa@SMA_Q9XEV3_ORYSA[2][RRM1:100%][KOG0148:100%]
Embryophyta@PRO_NP_188026[30][RRM1:100%***][oligoU:43%**][KOG0148:100%***]Vanderwaltozyma polyspora_DSM_70294@REF_XP_001647444[RRM1][KOG0123]
Saccharomycetaceae@SMA_PES4_YEAST[13][RRM1:100%**][KOG0123:100%**]Candida_glabrata@PRO_XP_447635[3][RRM1:100%*][KOG0123:100%*]
rosids@PRO_30078_m002213[5][RRM1:100%*][PABP:60%*][KOG0123:100%*]Ricinus communis@PRO_30146_m003481[RRM1][KOG0123]
Arabidopsis thaliana@PRO_NP_188259[3][RRM1:100%*][PABP:100%*][KOG0123:100%*]Oryza sativa_japonica_cultivar-group@PRO_NP_001049727[2][RRM1:100%][KOG0123:100%]
Leishmania@REF_XP_001565513[5][RRM1:100%*][KOG0123:100%*]Trypanosomatidae@REF_XP_001568515[11][RRM1:100%**][KOG0123:100%**]
Danio rerio@PRO_ENSDARP00000091192[32][RRM1:100%***][put-sr:97%***][KOG0123:100%***]Tetraodon nigroviridis@PRO_GSTENP00024897001[RRM1][PABP][KOG0123]
Pan troglodytes@SMA_UPI00004927B4[RRM1][PABP][KOG0123]Eukaryota@PRO_ENSXETP00000023927[663][RRM1:100%******][PABP:56%*****][KOG0123:100%******]
Tetraodon nigroviridis@SMA_Q4RJX8_TETNG[RRM1][KOG0123]Ciona intestinalis@PRO_ENSCINP00000004384[RRM2][KOG0148]
Nematostella vectensis@REF_XP_001624592[RRM2][KOG0148]Entamoeba histolytica_HM-1_IMSS@SMA_Q50Q39_ENTHI[2][RRM2:100%][KOG0148:100%]
Dictyostelium discoideum_AX4@PRO_XP_641688[3][RRM1:100%*][KOG0117:100%*]Strongylocentrotus purpuratus@PRO_XP_001183631[5][RRM2:100%*][KOG0148:100%*]
Physcomitrella patens@PRO_jgi_Phypa1_1_170658[RRM1]Phaeodactylum tricornutum@PRO_jgi_Phatr2_13402[RRM1][KOG0226]
Thalassiosira pseudonana@PRO_jgi_Thaps3_18991[RRM1][KOG0226]Cryptococcus_neoformans_var._neoformans@PRO_XP_571861_RRM
Trichomonas vaginalis_G3@REF_XP_001324421[RRM1][KOG0226]Nasonia vitripennis@PRO_XP_001603091[2][RRM1:100%][KOG0226:100%]Eukaryota@PRO_XP_964958[208][RRM1:100%*****][KOG0226:100%*****]
Eukaryota@PRO_IMGA_AC144483_30_2[327][RRM2:85%*****][.RRM1:15%***][TIATIAR:53%*****][.oligoU:5%**][KOG0148:99%*****]Ustilago maydis_521@PRO_XP_757329[3][RRM2:100%*][KOG0145:100%*]
Yarrowia lipolytica@PRO_XP_501542[3][RRM2:100%*][KOG0131:100%*]Saccharomycetales@REF_XP_001525917[4][RRM2:75%*][.RRM1:25%][put-sr:75%*][KOG0148:100%*]
Saccharomycetaceae@PRO_XP_461354[6][RRM2:83%*][.RRM1:17%][KOG0148:100%*]Dictyostelium discoideum_AX4@PRO_XP_635179[3][RRM1:100%*][KOG0148:100%*]
Aureococcus anophagefferens@PRO_jgi_Auran1_28594[RRM2][KOG0148]Saccharomycetales@PRO_XP_448512[22][RRM1:68%**][.RRM2:32%*][KOG0148:73%**][.KOG3598:14%*][.KOG0145:14%*]
Strongylocentrotus purpuratus@PRO_XP_793862[5][RRM2:80%*][.RRM1:20%][KOG0144:80%*][.KOG0148:20%]Endopterygota@PRO_AAEL011988-PA[16][RRM2:94%**][.RRM1:6%][KOG0144:62%**][.KOG0145:31%*][.KOG0123:6%]
Schistosoma japonicum@SMA_Q5DE20_SCHJA[RRM2][KOG0123]Gallus gallus@SMA_UPI0000447A2F[RRM1]
Eukaryota@PRO_ENSMUSP00000030730[184][RRM2:86%*****][.RRM1:14%***][oligoU:12%***][KOG0148:64%****][.KOG0123:19%***][.KOG0131:11%**]Caenorhabditis@SMA_Q22318_CAEEL[2][RRM2:100%][KOG0144:100%]
Cyanidioschyzon merolae@PRO_gnl_CMER_CMS187C[RRM1][KOG0123]Trichomonas vaginalis_G3@REF_XP_001309092[RRM2][KOG0123]
Chlamydomonadales@PRO_jgi_Volca1_107765[2][RRM1:100%][KOG0145:100%]Dictyostelium discoideum_AX4@PRO_XP_629639[3][RRM1:100%*][KOG0145:100%*]
Nematostella vectensis@REF_XP_001634736[RRM1][KOG0145]Trypanosoma_cruzi@REF_XP_803891[2][RRM1:100%][put-sr:100%][KOG0145:100%]
Eumetazoa@PRO_ENSORLP00000021434[539][RRM1:100%******][ELAV:70%*****][KOG0145:100%******]Drosophila melanogaster@PRO_CG5213-PA[3][RRM1:100%*][KOG0145:100%*]
Trypanosomatidae@REF_XP_806018[11][RRM1:100%**][KOG0145:100%**]Trypanosomatidae@PRO_XP_828145[27][RRM1:100%***][KOG0145:100%***]Trypanosoma@PRO_XP_845996[6][RRM1:100%*][KOG0145:50%*][.KOG0122:50%*]
Trypanosomatidae@PRO_XP_829272[11][RRM1:100%**][KOG0122:73%**][.KOG0145:27%*]Leishmania@PRO_XP_001463468[5][RRM1:100%*]
Trypanosomatidae@SMA_Q382W9_9TRYP[11][RRM1:100%**][KOG0145:45%*]Bilateria@SMA_UPI000065CB41[270][RRM1:100%*****][RBMS:74%*****][KOG0145:99%*****]
Schizosaccharomyces pombe@SMA_O94381_SCHPO[RRM1][KOG0145]Sordariales@SMA_Q2H0P1_CHAGB[2][RRM1:100%][KOG0145:100%]Aspergillus fumigatus@SMA_Q4WM63_ASPFU[RRM1][KOG0145]
Trypanosomatidae@SMA_Q57W93_9TRYP[11][RRM1:100%**]Leishmania@REF_XP_001683407[5][RRM1:100%*]Trypanosoma@REF_XP_811157[6][RRM2:100%*][KOG0145:50%*]Trypanosoma@SMA_Q4DZG2_TRYCR[6][RRM1:100%*][KOG0145:50%*]
Leishmania@PRO_XP_001463160[4][RRM2:100%*][put-sr:100%*]Leishmania major@SMA_Q4QJ00_LEIMA[RRM1][put-sr]
Tetrahymena thermophila_SB210@REF_XP_001023873[2][RRM1:100%][KOG0108:100%]Paramecium tetraurelia@REF_XP_001435827[2][RRM1:100%][KOG4208:100%]
Dictyostelium_discoideum@PRO_XP_643547[4][RRM1:100%*]Anopheles_gambiae@PRO_AGAP006090-PA[4][RRM1:100%*][KOG4208:25%]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_45356[RRM1][KOG4208]Eukaryota@PRO_CG6937-PA[195][RRM1:100%*****][KOG4208:98%*****]
Caenorhabditis@REF_XP_001665662[5][RRM1:100%*][KOG4208:100%*]Trypanosomatidae@PRO_XP_001467067[14][RRM1:100%**][KOG0144:100%**]
Leishmania major_strain_Friedlin@SMA_Q4FXR5_LEIMA[RRM1][KOG0144]Dictyostelium discoideum_AX4@SMA_Q556F3_DICDI[3][RRM1:100%*][KOG0123:100%*]
Dictyostelium discoideum_AX4@SMA_Q55BM9_DICDI[3][RRM1:100%*][KOG0145:100%*]Guillardia theta@REF_NP_113243[2][RRM2:100%][KOG0123:100%]
Dictyostelium discoideum_AX4@SMA_Q54G90_DICDI[3][RRM2:100%*][KOG0145:100%*]Dictyostelium discoideum_AX4@PRO_XP_635793[3][RRM1:100%*][KOG0145:100%*]
Trichomonas vaginalis_G3@REF_XP_001319541[RRM1][KOG0144]Trichomonas vaginalis_G3@REF_XP_001579752[2][RRM1:100%][KOG0145:100%]
Trichomonas vaginalis_G3@REF_XP_001325514[RRM1][KOG0145]Kluyveromyces lactis@SMA_Q6CXV3_KLULA[RRM2][KOG0144]
Saccharomycetales@SMA_Q6FTW8_CANGA[2][RRM3:50%][.RRM2:50%][KOG0108:50%]Dictyostelium discoideum_AX4@PRO_XP_644081[3][RRM3:100%*][KOG0123:100%*]
82
10 - ELAV
77 - TIA TIAR
OligoU
3 - PABP
76 - TIA TIAR
OligoU
86 - hnRNP
RALYL
62
Fig. S9
124
52
70 65
65
67
61
63 67
96
56 64
68
70
77
63
83
67
Coelomata@PRO CG4787 PA[243][RRM3:73%*****][ RRM2:16%***][ RRM1:12%***][TIATIAR:75%*****][KOG0148:100%*****]Caenorhabditis@PRO_Y46G5A_13[22][RRM2:55%**][.RRM3:45%**][KOG0148:100%***]
Embryophyta@SMA_Q1SGW2_MEDTR[34][RRM3:91%***][.RRM2:9%*][oligoU:47%**][KOG0148:100%***]Entamoeba histolytica_HM-1_IMSS@SMA_Q50Q39_ENTHI[2][RRM3:100%][KOG0148:100%]
Dikarya@REF_XP_001486325[48][RRM3:94%***][put-sr:19%**][KOG0148:96%***]Anopheles_gambiae@SMA_ENSANGP00000019784[2][RRM1:100%]
Anopheles gambiae_str._PEST@SMA_Q7QK15_ANOGA[RRM1]Euteleostomi@SMA_ENSDARP00000002433[17][RRM2:100%**][RBM:59%**][KOG0144:76%**][.KOG0145:18%*]
Apocrita@PRO_XP_001604889[3][RRM2:100%*][KOG0144:100%*]Dictyostelium discoideum_AX4@PRO_XP_636266[3][RRM1:100%*][KOG3598:100%*]
Endopterygota@PRO_CG1316-PA[17][RRM1:100%**][KOG0144:71%**][.KOG0148:29%*]Euteleostomi@PRO_ENSDNOP00000001522[53][RRM1:100%***][RBM:64%***][KOG0144:83%***][.KOG0145:13%*]
Strongylocentrotus purpuratus@PRO_XP_001199679[9][RRM1:100%**][KOG0145:56%*]Culicidae@PRO_AAEL001131-PA[6][RRM1:100%*][KOG0113:100%*]
Nematostella vectensis@REF_XP_001638999[RRM2][KOG0144]Ciona@PRO_ENSCSAVP00000018820[2][RRM2:100%][KOG0145:100%]
Euteleostomi@PRO_ENSXETP00000044031[104][RRM2:79%****][.RRM1:21%***][KOG0145:38%***][.KOG0123:18%**][.KOG0110:12%**]Nematostella vectensis@REF_XP_001630797[RRM2][KOG0117]
Eumetazoa@PRO_ENSLAFP00000012959[458][RRM3:90%******][.RRM2:7%***][hnRNP:36%*****][KOG0117:100%******]Aureococcus anophagefferens@PRO_jgi_Auran1_31715[RRM1][KOG0149]Volvox carteri@PRO_jgi_Volca1_84128[RRM2][KOG0147]
Oryza_sativa@SMA_Q259G3_ORYSA[4][RRM4:100%*][KOG0123:100%*]Oryza_sativa@SMA_Q259G3_ORYSA[4][RRM5:100%*][KOG0123:100%*]
Ustilago maydis_521@SMA_Q4PI09_USTMA[3][RRM1:100%*]Cryptococcus neoformans_var._neoformans_B-3501A@SMA_Q55MI2_CRYN
Embryophyta@PRO_jgi_Phypa1_1_189930[13][RRM1:100%**][KOG0119:85%**][.KOG0307:15%]Oryza_sativa@SMA_Q259G3_ORYSA[4][RRM6:100%*][KOG0123:100%*]
Oryza_sativa@SMA_Q259G3_ORYSA[4][RRM1:100%*][KOG0123:100%*]Oryza_sativa@PRO_NP_001054296[4][RRM2:100%*][KOG0123:100%*]
Drosophila melanogaster@PRO_CG5213-PA[3][RRM2:100%*][KOG0145:100%*]Anopheles gambiae_str._PEST@SMA_Q5TTX2_ANOGA[RRM1]
Caenorhabditis@REF_XP_001664781[8][RRM1:100%**][KOG0115:100%**]Ricinus communis@PRO_30169_m006629[RRM1][KOG0123]
Filobasidiella_neoformans@PRO_XP_572996[5][RRM1:100%*]Ustilago maydis_521@PRO_XP_760296[3][RRM1:100%*]
Endopterygota@REF_NP_001040210[9][RRM1:100%**]Drosophila melanogaster@PRO_CG14414-PB[3][RRM1:100%*]
Euteleostomi@PRO_ENSOANP00000013028[46][RRM1:100%***]Nematostella vectensis@REF_XP_001638014[RRM1]
Trypanosomatidae@SMA_Q57TU8_9TRYP[11][RRM1:100%**][KOG0110:45%*][.KOG0127:27%*][.KOG0145:18%][.KOG0144:9%]Leishmania@PRO_XP_001466659[5][RRM1:100%*][KOG0145:100%*]
Leishmania@SMA_Q4FXR8_LEIMA[5][RRM1:100%*][KOG0110:100%*]Trypanosoma@SMA_Q57WC9_9TRYP[15][RRM1:100%**][put-sr:20%*][KOG0110:100%**]
Leishmania@SMA_Q4FXR7_LEIMA[5][RRM1:100%*][KOG0148:60%*][.KOG0145:40%]Leishmania@REF_XP_001563945[10][RRM1:100%**][put-sr:10%][KOG0145:100%**]
Leishmania@PRO_XP_001464836[5][RRM1:100%*][KOG0145:80%*][.KOG0148:20%]Endopterygota@SMA_SXL_CHRRU[56][RRM2:100%****][KOG0145:100%****]
Trichocomaceae@SMA_Q5BFT8_EMENI[3][RRM1:67%][.RRM2:33%][KOG0145:67%]Eumetazoa@PRO_ENSORLP00000004891[177][RRM2:92%*****][.RRM1:8%**][RBMS:80%****][KOG0145:100%*****]Sordariomycetes@SMA_UPI000021B021[4][RRM2:100%*][KOG0145:100%*]
Nematostella vectensis@REF_XP_001634736[RRM2][KOG0145]Ustilago maydis_521@PRO_XP_759141[3][RRM2:100%*][KOG0145:100%*]
Bilateria@SMA_Q966S6_BRABE[470][RRM2:95%******][.RRM1:5%***][ELAV:83%*****][KOG0145:100%******]Nematostella vectensis@REF_XP_001626979[RRM2][KOG0145]
Thalassiosira pseudonana@PRO_jgi_Thaps3_261541[RRM2][KOG0144]Apicomplexa@REF_XP_678037[28][RRM2:96%***][put-sr:14%*][KOG0144:96%***]
Embryophyta@PRO_29889_m003323[28][RRM2:96%***][FCAFPA:36%**][KOG0144:100%***]Cryptosporidium_parvum@PRO_XP_628265[3][RRM2:100%*][KOG0144:100%*]
Tetrahymena thermophila_SB210@SMA_Q22JW7_TETTH[2][RRM2:100%][KOG0144:100%]Eumetazoa@SMA_ENSANGP00000005501[568][RRM2:74%******][.RRM1:26%****][Bruno:56%*****][KOG0146:53%*****][.KOG0144:47%*****]
Dictyostelium discoideum_AX4@SMA_Q54EJ3_DICDI[3][RRM2:100%*][KOG0144:100%*]Dictyostelium discoideum_AX4@SMA_Q55D63_DICDI[3][RRM2:100%*][KOG0146:100%*]
Phytophthora@PRO_jgi_Physo1_1_133760[2][RRM2:100%][KOG0144:100%]Embryophyta@PRO_jgi_Phypa1_1_115029[20][RRM2:95%**][.RRM1:5%][KOG0144:100%**]
Oryza sativa_japonica_cultivar-group@SMA_Q7XAN8_ORYSA[3][RRM2:100%*][KOG0144:100%*]Volvox carteri@PRO_jgi_Volca1_72841[RRM1][KOG0144]
Chlamydomonadales@SMA_Q6RBZ0_CHLRE[3][RRM1:67%][.RRM2:33%][KOG0144:100%*]Chlamydomonadales@PRO_jgi_Volca1_72841[3][RRM2:67%][.RRM3:33%][KOG0144:100%*]Trypanosomatidae@SMA_Q4E5H3_TRYCR[10][RRM1:100%**][KOG0144:100%**]Chlamydomonadales@PRO_jgi_Volca1_118581[3][RRM2:67%][.RRM4:33%][KOG0144:67%][.KOG1240:33%]
Volvox carteri@PRO_jgi_Volca1_88093[RRM4][KOG1240]Embryophyta@PRO_30076_m004622[20][RRM1:100%**][FCAFPA:30%*][KOG0144:100%**]
Arabidopsis thaliana@SMA_O22905_ARATH[4][RRM1:100%*][FCAFPA:100%*][KOG0144:100%*]Medicago truncatula@PRO_IMGA_AC155099_2_2[3][RRM1:100%*][KOG0144:100%*]Chlamydomonadales@PRO_jgi_Volca1_88093[2][RRM1:100%][KOG1240:100%]
Thalassiosira pseudonana@PRO_jgi_Thaps3_261541[RRM1][KOG0144]Phaeodactylum tricornutum@PRO_jgi_Phatr2_42828[RRM1][KOG0144]
Phytophthora@PRO_jgi_Phyra1_1_82644[2][RRM1:100%][KOG0144:100%]Cryptosporidium@SMA_Q5CJX5_CRYHO[4][RRM1:100%*][put-sr:100%*][KOG0144:100%*]
Aconoidasida@SMA_Q8IDB7_PLAF7[17][RRM1:100%**][KOG0144:100%**]Plasmodium_vivax@SMA_Q4Z2X6_PLABE[3][RRM1:100%*][KOG0144:100%*]
Plasmodium@REF_XP_001614930[11][RRM1:100%**][KOG0146:55%*][.KOG0145:27%*][.KOG0144:18%]Theileria@SMA_Q4N6G9_THEPA[5][RRM1:100%*][KOG0144:100%*]
Eumetazoa@SMA_UPI0000583CBC[354][RRM1:100%*****][Bruno:51%*****][KOG0146:56%*****][.KOG0144:44%*****]Tetrahymena thermophila_SB210@REF_XP_001033355[2][RRM1:100%][KOG0144:100%]
Tetrahymena thermophila_SB210@SMA_Q242R7_TETTH[RRM1][KOG0144]Trypanosomatidae@SMA_Q57U22_9TRYP[12][RRM1:100%**][KOG0144:33%*][.KOG0131:25%*]
Leishmania@PRO_XP_001468236[2][RRM1:100%]Trypanosomatidae@PRO_XP_001468238[22][RRM1:100%***][KOG0144:100%***]
Embryophyta@PRO_jgi_Phypa1_1_107590[15][RRM1:100%**][KOG0144:100%**]Cryptosporidium_parvum@SMA_Q5CYW5_CRYPV[3][RRM1:100%*][KOG0144:100%*]
Dictyostelium discoideum_AX4@PRO_XP_646268[3][RRM1:100%*][KOG0146:100%*]Rattus norvegicus@SMA_UPI000050653E[RRM1][KOG0146]
Dictyostelium discoideum_AX4@SMA_Q54EJ3_DICDI[3][RRM1:100%*][KOG0144:100%*]Trichomonas vaginalis_G3@REF_XP_001312833[RRM1]Endopterygota@SMA_UPI0000D5773E[17][RRM1:100%**][put-sr:100%**][KOG0132:100%**]
Euteleostomi@SMA_UPI0000D61501[57][RRM1:100%****][put-sr:95%***][KOG0132:100%****]Theileria@REF_XP_953895[5][RRM2:100%*][put-sr:100%*][KOG4205:100%*]
Babesia bovis@REF_XP_001610820[RRM2][KOG4205]Saccharomyces cerevisiae@PRO_YGR250C[3][RRM1:100%*][KOG0108:100%*]
Saccharomycetaceae@SMA_Q6CXV3_KLULA[7][RRM1:100%*][put-sr:14%][KOG0144:86%*][.KOG0108:14%]Paramecium tetraurelia@REF_XP_001458533[RRM1][put-sr]
Sordariomycetes@SMA_Q2KH70_MAGGR[3][RRM1:100%*][KOG0153:100%*]Euteleostomi@PRO_ENSMODP00000018834[60][RRM1:100%****][put-sr:70%***][KOG0147:47%***][.KOG0132:18%**]
Ciona intestinalis@SMA_ENSCINP00000011919[RRM1]Ciona intestinalis@PRO_ENSCINP00000027768[2][RRM1:100%][KOG0548:100%]
Dictyostelium_discoideum@PRO_XP_640243[4][RRM1:100%*][KOG0117:100%*]Cryptosporidium@SMA_Q5CI46_CRYHO[2][RRM1:100%]
Trypanosoma brucei_TREU927@PRO_XP_845742[2][RRM1:100%][KOG0126:100%]Eukaryota@PRO_ENSCINP00000014101[206][RRM1:100%*****][put-sr:35%****][KOG0126:100%*****]
Ustilago maydis_521@PRO_XP_760864[3][RRM1:100%*][KOG0126:100%*]Entamoeba histolytica_HM-1_IMSS@REF_XP_656000[2][RRM1:100%][KOG0126:100%]
Embryophyta@PRO_NP_001067623[18][RRM1:100%**][KOG0117:100%**]Oryza sativa_japonica_cultivar-group@PRO_NP_001066102[3][RRM1:100%*][KOG0117:100%*]rosids@PRO_NP_001030849[10][RRM1:100%**][KOG0117:100%**]
Oryza sativa_japonica_cultivar-group@PRO_NP_001064224[3][RRM1:100%*][KOG0117:100%*]Magnoliophyta@SMA_Q6YH14_VITVI[13][RRM1:100%**][put-sr:8%][KOG0117:100%**]
Physcomitrella patens@PRO_jgi_Phypa1_1_140180[3][RRM1:100%*][KOG0117:100%*]Ricinus communis@PRO_30072_m000974[RRM1][KOG0117]
Oryza sativa_japonica_cultivar-group@SMA_Q6ZLD1_ORYSA[RRM1][KOG0117] 62
69
7 - Bruno
FCA FPA
8 - Bruno
FCA FPA
11 - ELAV
RBMS
part of 63 - hnRNP
79 - TIA TIAR
OligoU
15
Fig. S9
125
88
58
66
53
69
88
83
64
52
88
68
Ciona@PRO ENSCSAVP00000005375[6][RRM2:83%*][ RRM1:17%][KOG0116:83%*][ KOG2141:17%]Trichomonas vaginalis_G3@REF_XP_001319495[RRM1]
Encephalitozoon_cuniculi@SMA_Q8SSA1_ENCCU[3][RRM1:100%*][KOG4205:100%*]Physcomitrella patens@PRO_jgi_Phypa1_1_167900[RRM2][KOG1015]
Physcomitrella patens@PRO_jgi_Phypa1_1_188347[RRM2][KOG0123]Magnoliophyta@SMA_Q9FVQ1_ARATH[11][RRM2:91%**][.RRM1:9%][nucleolin:18%][KOG0123:55%*][.KOG4210:18%][.KOG1015:18%][.KOG0148:9%]
Arabidopsis thaliana@PRO_NP_188491[3][RRM2:100%*][nucleolin:100%*][KOG4210:100%*]Sordariomycetes@REF_XP_001221988[7][RRM2:86%*][.RRM1:14%][KOG0110:71%*][.KOG0108:14%][.KOG0123:14%]
Pezizomycotina@REF_XP_001262069[12][RRM2:100%**][KOG0110:83%**][.KOG0148:17%]Aureococcus anophagefferens@PRO_jgi_Auran1_9375[2][RRM1:100%][KOG0122:100%]
Aureococcus anophagefferens@PRO_jgi_Auran1_17018[RRM1][KOG0111]Opitutaceae bacterium_TAV2@REF_ZP_02010994[RRM1][PROK][KOG0108]
Thalassiosira pseudonana@PRO_jgi_Thaps3_33709[RRM1][KOG0111]Eukaryota@PRO_8925_m000027_AZM5_1178[175][RRM1:100%*****][put-sr:87%*****][SR:60%****][KOG4207:60%****][.KOG4368:22%***]
Thalassiosira pseudonana@PRO_jgi_Thaps3_20266[RRM1][KOG4207]Bacillariophyta@PRO_jgi_Thaps3_20223[2][RRM1:100%][KOG0108:100%]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_8270[RRM1][KOG4207]Phaeodactylum tricornutum@PRO_jgi_Phatr2_49481[RRM1][KOG1337]
Cryptosporidium@PRO_XP_626081[5][RRM1:100%*][KOG0122:100%*]Pezizomycotina@PRO_XP_962933[24][RRM2:100%***][put-sr:12%*][KOG0127:100%***]
Ascomycota@PRO_XP_499726[23][RRM2:100%***][KOG0127:100%***]Plesiocystis pacifica_SIR-1@REF_ZP_01913111[RRM1][PROK][KOG0149]
Guillardia theta@SMA_Q5K255_GUITH[RRM1][put-sr][KOG0116]Chlamydomonadales@PRO_jgi_Chlre3_184151[3][RRM1:100%*][KOG0116:67%][.KOG0921:33%]
Schizosaccharomyces_pombe@PRO_NP_595090[3][RRM1:100%*]Saccharomycetales@PRO_YHL034C[4][RRM1:100%*]
Kluyveromyces lactis@PRO_XP_453971[RRM1]Trichomonas vaginalis_G3@REF_XP_001582304[RRM1]
Entamoeba histolytica_HM-1_IMSS@REF_XP_651660[2][RRM1:100%][KOG0117:100%]Cryptosporidium@SMA_Q5CKZ4_CRYHO[2][RRM1:100%]
Dictyostelium discoideum_AX4@SMA_Q55GV1_DICDI[3][RRM1:100%*]Ustilago maydis_521@SMA_Q4PBP1_USTMA[RRM1]
Filobasidiella_neoformans@PRO_XP_567374[4][RRM1:100%*][KOG0307:100%*]Embryophyta@PRO_30128_m008555[34][RRM1:100%***][KOG4660:100%***]
Entamoeba histolytica_HM-1_IMSS@SMA_Q511G8_ENTHI[RRM1][KOG4660]Chlamydomonas reinhardtii@PRO_jgi_Chlre3_152680[RRM1][KOG4660]
Filobasidiella_neoformans@SMA_Q55HC8_CRYNE[2][RRM2:100%][KOG0127:100%]Dictyostelium discoideum_AX4@PRO_XP_646584[3][RRM2:100%*][KOG0127:100%*]
Culicidae@PRO_AAEL010888-PA[3][RRM2:100%*]Aureococcus anophagefferens@PRO_jgi_Auran1_9018[RRM1]
Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_8174[2][RRM1:100%][KOG4207:100%]Ostreococcus@PRO_jgi_Ostta4_7793[3][RRM1:100%*][KOG0108:100%*]
Aureococcus anophagefferens@PRO_jgi_Auran1_17068[RRM1][KOG4207]Apicomplexa@REF_XP_764028[35][RRM1:100%***][put-sr:54%**][KOG4207:66%***][.KOG0111:14%*]
Murinae@PRO_ENSMUSP00000078984[6][RRM1:100%*][KOG4207:100%*]Phytophthora@PRO_jgi_Physo1_1_136528[2][RRM1:100%][put-sr:50%][KOG3208:50%]
Chlamydomonadales@PRO_jgi_Volca1_121229[2][RRM1:100%][put-sr:100%][KOG0415:50%]Bacillariophyta@PRO_jgi_Thaps3_23196[2][RRM1:100%][KOG4207:50%]
Phytophthora sojae@PRO_jgi_Physo1_1_138511[RRM1][put-sr]Viridiplantae@PRO_NP_001046448[46][RRM1:100%***][put-sr:96%***][SR:54%***][KOG0127:15%*][.KOG0110:11%*][.KOG4207:9%*][.KOG0122:9%*]
Schistosoma japonicum@SMA_Q86EX2_SCHJA[RRM1][put-sr]Eumetazoa@PRO_ENSETEP00000001114[107][RRM1:100%****][put-sr:93%****][SRrp:82%****][KOG0111:33%***][.KOG0415:17%**][.KOG4207:8%**]
Ciona@SMA_Q9U5Y7_CIOIN[6][RRM1:100%*][KOG0108:100%*]Euteleostomi@PRO_ENSORLP00000006283[3][RRM1:100%*][LA:67%][KOG1855:100%*]
Euteleostomi@PRO_GSTENP00013801001[72][RRM1:100%****][LA:71%***][KOG1855:97%****]Strongylocentrotus purpuratus@SMA_UPI0000586A7E[RRM1][KOG1855]
Nematostella vectensis@REF_XP_001625158[RRM1][KOG1855]Anopheles_gambiae@SMA_ENSANGP00000006836[3][RRM1:100%*][KOG1855:100%*]
Apocrita@PRO_XP_001600355[4][RRM1:100%*][KOG1855:100%*]Tribolium castaneum@SMA_UPI0000D55A0F[3][RRM1:100%*][KOG1855:100%*]
Trichomonas vaginalis_G3@REF_XP_001328836[RRM1]Drosophila melanogaster@PRO_CG3312-PA[5][RRM1:100%*][KOG0128:100%*]
Magnaporthe grisea_70-15@SMA_UPI000021BBA8[RRM2][KOG0123]Chaetomium globosum_CBS_148.51@REF_XP_001222664[2][RRM2:100%][KOG0123:100%]Schizosaccharomyces_pombe@PRO_NP_593427[3][RRM1:100%*][KOG0123:100%*]
Coelomata@REF_XP_001507449[6][RRM1:100%*][KOG1457:100%*]Ricinus communis@PRO_28452_m000049[RRM1][KOG1457]
Medicago truncatula@PRO_IMGA_CU012061_4_1[RRM1]Oryza sativa_japonica_cultivar-group@REF_NP_001063729[RRM1]
Pedobacter sp._BAL39@REF_ZP_01882800[RRM1][PROK][KOG0126]Endopterygota@SMA_Q9VAC9_DROME[21][RRM1:100%***][KOG0109:62%**]
Euteleostomi@PRO_ENSTBEP00000003150[66][RRM1:100%****][RBM:56%***][.LARK:5%*][KOG0109:98%****]Nematostella vectensis@REF_XP_001622030[RRM1][put-sr][KOG0109]
Euteleostomi@SMA_Q4SYG3_TETNG[162][RRM2:93%*****][LARK:56%****][.RBM:21%***][KOG0109:98%*****]Strongylocentrotus purpuratus@PRO_XP_792521[9][RRM1:100%**][put-sr:100%**][KOG0109:100%**]
Clupeocephala@PRO_ENSORLP00000002364[17][RRM2:100%**][KOG0109:100%**]Drosophila melanogaster@REF_NP_659571[RRM1]
Sophophora@SMA_Q7KLX0_DROME[2][RRM1:100%]Bilateria@SMA_ENSCINP00000023722[197][RRM1:85%*****][.RRM2:13%***][LARK:61%****][KOG0109:98%*****]
Ciona intestinalis@PRO_ENSCINP00000017840[RRM1][KOG0109]Danio rerio@PRO_ENSDARP00000065401[3][RRM2:100%*][KOG0109:100%*]
Caenorhabditis@SMA_RNP1_CAEEL[2][RRM1:100%][KOG0109:100%]Ciona intestinalis@PRO_ENSCINP00000017840[RRM2][KOG0109]
Ciona@PRO_ENSCSAVP00000017501[2][RRM1:50%][.RRM2:50%][KOG0109:50%]Trypanosomatidae@PRO_XP_847474[11][RRM1:100%**]
Trichomonas vaginalis_G3@REF_XP_001303000[RRM1][KOG0113]Cryptococcus_neoformans_var._neoformans@PRO_XP_566745_RRM
Physcomitrella patens@PRO_jgi_Phypa1_1_93324[RRM1]Schizosaccharomyces pombe@SMA_MSA1_SCHPO[RRM2][KOG0123]
Trypanosoma@PRO_XP_845376[2][RRM1:50%][.RRM3:50%][KOG0148:50%]Saccharomycetales@PRO_XP_001384462[10][RRM2:90%**][.RRM1:10%][KOG0117:70%*]
Pichia guilliermondii_ATCC_6260@REF_XP_001482891[RRM2]Saccharomycetales@REF_XP_001643628[10][RRM2:100%**][KOG0123:30%*]
Kluyveromyces lactis@PRO_XP_455897[3][RRM2:100%*][KOG0123:100%*]Dictyostelium discoideum_AX4@PRO_XP_641568[3][RRM2:67%][.RRM1:33%][KOG3598:100%*]
Legionella_pneumophila@SMA_Q5X8D2_LEGPA[8][RRM1:100%**][PROK:100%**][put-sr:100%**][KOG0149:100%**]Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_7602[2][RRM1:100%][KOG0145:100%]
Caenorhabditis@REF_XP_001665847[3][RRM1:100%*][KOG0108:100%*]Aedes aegypti@PRO_AAEL010101-PA[2][RRM1:100%]Anopheles_gambiae@PRO_AGAP007689-PA[2][RRM1:100%]
Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_32831[2][RRM1:100%]Cryptococcus neoformans_var._neoformans_B-3501A@SMA_Q55Z21_CRYN
Bos taurus@REF_XP_875206[RRM1]Oryza sativa_japonica_cultivar-group@SMA_Q6H4H7_ORYSA[2][RRM1:100%][KOG1520:50%][.KOG0122:50%]
Oryza sativa_japonica_cultivar-group@SMA_Q2QMF0_ORYSA[RRM1][KOG0122]Filobasidiella_neoformans@PRO_XP_569209[4][RRM2:100%*][KOG0144:100%*]
Plesiocystis pacifica_SIR-1@REF_ZP_01911510[RRM1][PROK]Paramecium tetraurelia@REF_XP_001459639[RRM2][KOG0120]Ciona@PRO_ENSCSAVP00000015853[5][RRM2:100%*][KOG0145:100%*]
Ciona@PRO_ENSCINP00000023191[5][RRM3:80%*][.RRM1:20%][KOG0145:100%*]Nematostella vectensis@REF_XP_001634736[RRM3][KOG0145]
Coelomata@PRO_ENSTBEP00000015452[492][RRM3:91%******][.RRM2:6%***][ELAV:80%*****][KOG0145:100%******]Caenorhabditis@REF_XP_001678192[5][RRM3:100%*][KOG0145:100%*]
Nematostella vectensis@REF_XP_001626979[RRM3][KOG0145]Dictyostelium discoideum_AX4@SMA_Q54G90_DICDI[3][RRM3:100%*][KOG0145:100%*]
Saccharomycetales@PRO_NP_984279[13][RRM1:100%**][KOG0921:77%**][.KOG0106:23%*]Entamoeba histolytica_HM-1_IMSS@REF_XP_655235[2][RRM1:100%]
Dictyostelium discoideum_AX4@SMA_Q55CI7_DICDI[RRM1]Caenorhabditis@REF_XP_001676254[5][RRM2:100%*][KOG0148:100%*]Coelomata@PRO_CG4787-PA[243][RRM3:73%*****][.RRM2:16%***][.RRM1:12%***][TIATIAR:75%*****][KOG0148:100%*****] OligoU
12 - ELAV
51 - LARK
50 - LARK
52
81 - La
part of 22 - single-RRM
SR proteins
part of 22 - single-RRM
SR proteins
23 - SRrp
4225
Fungal SR (ScNp13) ?Fig. S9
126
59
84
69
95 73
59
93 74
89
79
72
73
Strongylocentrotus purpuratus@PRO NP 999784[8][RRM1:100%**][KOG4205:100%**]Dictyostelium discoideum_AX4@SMA_Q54D98_DICDI[RRM1][KOG4205]
Eukaryota@PRO_ENSMODP00000031317[717][RRM1:100%******][hnRNP:29%*****][.Musashi:15%****][.Dazap:7%***][KOG4205:100%******]Phytophthora ramorum@PRO_jgi_Phyra1_1_73884[RRM1][KOG4205]
Aureococcus anophagefferens@PRO_jgi_Auran1_6078[RRM1][KOG4205]Strongylocentrotus purpuratus@SMA_UPI0000584744[7][RRM1:100%*][KOG4205:100%*]
Strongylocentrotus purpuratus@SMA_UPI000058437F[RRM1][KOG4205]Strongylocentrotus purpuratus@SMA_UPI0000585178[5][RRM1:100%*][KOG4205:100%*]
Plasmodium@REF_XP_001615026[12][RRM1:100%**][KOG4205:100%**]Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_24530[2][RRM1:100%][KOG4205:100%]
Oryza_sativa@PRO_NP_001067093[5][RRM1:100%*][KOG4177:100%*]Chlamydomonadales@PRO_jgi_Volca1_107445[2][RRM2:100%][KOG4205:100%]
Physcomitrella patens@PRO_jgi_Phypa1_1_19696[RRM1][KOG4205]Oryza sativa_japonica_cultivar-group@SMA_Q5ZAN1_ORYSA[2][RRM2:100%][KOG4205:100%]
Cryptosporidium_parvum@PRO_XP_626579[3][RRM2:67%][.RRM1:33%][KOG4205:100%*]Cryptosporidium@SMA_Q5CS11_CRYPV[4][RRM2:100%*][KOG4205:100%*]Cryptosporidium@SMA_Q5CEI5_CRYHO[4][RRM2:100%*][KOG4205:100%*]
Ricinus communis@PRO_28976_m000161[RRM2][KOG4205]Filobasidiella_neoformans@PRO_XP_568675[4][RRM2:100%*][KOG4205:100%*]
Endopterygota@PRO_AAEL008257-PA[26][RRM2:100%***][KOG4205:100%***]Viridiplantae@SMA_Q8W4A6_ARATH[35][RRM2:97%***][put-sr:17%*][KOG4205:97%***]
Caenorhabditis@SMA_Q4W5P0_CAEEL[15][RRM1:100%**][KOG4205:100%**]Ascomycota@REF_XP_723052[54][RRM2:100%***][put-sr:6%*][KOG4205:100%***]
Strongylocentrotus purpuratus@PRO_NP_999784[8][RRM2:100%**][KOG4205:100%**]Plasmodium@REF_XP_723811[8][RRM1:100%**][KOG0149:38%*][.KOG4205:38%*][.KOG0113:25%]
Babesia bovis@REF_XP_001609124[RRM1]Theileria@REF_XP_955210[4][RRM1:100%*][KOG0149:50%]
Plasmodium@REF_XP_001615199[6][RRM2:100%*][KOG0149:50%*][.KOG0113:33%][.KOG4205:17%]Theileria@SMA_Q4MZK1_THEPA[3][RRM2:100%*][KOG0149:67%]
Babesia bovis@REF_XP_001609123[RRM1][KOG0149]Embryophyta@PRO_IMGA_AC144431_42_2[12][RRM3:92%**][.RRM2:8%][put-sr:25%*][KOG4205:100%**]
Nematostella vectensis@REF_XP_001637003[RRM2][KOG4205]Coelomata@SMA_UPI000051750E[26][RRM2:100%***][TARDBP:15%*][KOG4205:100%***]
Embryophyta@PRO_jgi_Phypa1_1_112860[11][RRM2:100%**][put-sr:27%*][KOG4205:100%**]Chlamydomonadales@PRO_jgi_Chlre3_105806[2][RRM2:100%][KOG4205:100%]
Chlamydomonadales@PRO_jgi_Volca1_43575[2][RRM3:100%][KOG4205:100%]Encephalitozoon_cuniculi@PRO_NP_597487[2][RRM1:100%][KOG4205:100%]
Nematostella vectensis@REF_XP_001625489[RRM2][KOG4205]Caenorhabditis@REF_XP_001672132[5][RRM1:100%*]
Phytophthora ramorum@PRO_jgi_Phyra1_1_73884[RRM2][KOG4205]Bacillariophyta@PRO_jgi_Phatr2_21039[2][RRM1:100%][KOG4205:100%]
Piroplasmida@REF_XP_001610820[6][RRM1:100%*][put-sr:83%*][KOG4205:100%*]Plasmodium@SMA_Q7RMH6_PLAYO[5][RRM2:100%*][KOG4205:100%*]
Dictyostelium discoideum_AX4@SMA_Q552K5_DICDI[3][RRM1:100%*][KOG3598:100%*]Nematostella vectensis@REF_XP_001641412[RRM1][KOG4205]
Schistosoma japonicum@SMA_Q5DH48_SCHJA[RRM1][KOG4205]Endopterygota@SMA_Q297Q0_DROPS[53][RRM1:100%***][KOG4205:100%***]
Nematostella vectensis@REF_XP_001630480[RRM1][KOG4205]Myotis lucifugus@PRO_ENSMLUP00000003070[RRM1][hnRNP][KOG4205]
Oryctolagus cuniculus@PRO_ENSOCUP00000001170[RRM1][hnRNP][KOG4205]Dictyostelium discoideum_AX4@SMA_Q54D98_DICDI[3][RRM2:100%*][KOG4205:100%*]
Nematostella vectensis@REF_XP_001642130[RRM1][KOG4205]Piroplasmida@REF_XP_001611990[5][RRM2:100%*][KOG4205:100%*]
Ciona@PRO_ENSCINP00000009845[4][RRM1:100%*][KOG0116:100%*]Deuterostomia@REF_NP_001085483[190][RRM1:100%*****][G3BP:85%*****][KOG0116:100%*****]Apis mellifera@PRO_XP_623996[3][RRM1:100%*][KOG0116:100%*]
Tribolium castaneum@PRO_XP_975463[3][RRM1:100%*][KOG0116:100%*]Diptera@SMA_ENSANGP00000007476[2][RRM1:100%][KOG0116:100%]
Anopheles gambiae_str._PEST@SMA_Q5TV30_ANOGA[RRM1]Strongylocentrotus purpuratus@PRO_XP_001176409[7][RRM2:100%*][KOG4205:100%*]
Nematostella vectensis@REF_XP_001634214[RRM1][KOG4205]Canis familiaris@SMA_UPI00005A10B6[RRM1][hnRNP][KOG4205]
Canis familiaris@SMA_UPI00004BDE56[2][RRM1:100%][KOG4205:100%]Sorex araneus@PRO_ENSSARP00000008097[RRM2][hnRNP][KOG4205]
Caenorhabditis@REF_XP_001671843[15][RRM2:100%**][KOG4205:100%**]Bilateria@SMA_RB97D_DROME[955][RRM2:91%******][.RRM1:9%****][hnRNP:57%******][KOG4205:100%******]
Drosophila melanogaster@PRO_CG9654-PA[3][RRM2:100%*][KOG4205:100%*]Ciona intestinalis@PRO_ENSCINP00000012771[RRM2][put-sr][KOG4205]
Ciona@PRO_ENSCINP00000008394[8][RRM2:100%**][KOG4205:100%**]Paracentrotus lividus@SMA_Q6PNM9_PARLI[RRM2][KOG4205]
Caenorhabditis@SMA_Q4W5P0_CAEEL[15][RRM2:100%**][KOG4205:100%**]Physcomitrella patens@PRO_jgi_Phypa1_1_120016[RRM2][KOG4205]
Strongylocentrotus purpuratus@PRO_XP_001183095[5][RRM2:100%*][KOG4205:100%*]Nematostella vectensis@REF_XP_001641412[RRM2][KOG4205]
Eukaryota@SMA_Q5U4T5_XENLA[284][RRM2:86%*****][.RRM1:14%***][Musashi:41%****][.Dazap:18%***][.hnRNP:12%***][KOG4205:100%*****]Apis mellifera@SMA_UPI0000519F31[RRM2][KOG2281]
Ciona@PRO_ENSCSAVP00000001921[5][RRM2:100%*][Musashi:80%*][KOG4205:100%*]Halocynthia roretzi@SMA_Q9UAF2_HALRO[RRM2][Musashi][KOG4205]Ciona@SMA_ENSCINP00000028810[3][RRM2:100%*][KOG4205:100%*]
Ciona@PRO_ENSCSAVP00000016637[4][RRM2:100%*][KOG4205:100%*]Nematostella vectensis@REF_XP_001630480[RRM2][KOG4205]
Euteleostomi@PRO_ENSDARP00000005968[318][RRM2:97%*****][hnRNP:57%*****][KOG4205:100%*****]Endopterygota@SMA_UPI0000514895[54][RRM2:100%***][KOG4205:100%***]
Gammaproteobacteria@SMA_Q60AQ3_METCA[6][RRM1:100%*][PROK:100%*]Aureococcus anophagefferens@PRO_jgi_Auran1_1296[RRM1][KOG0110]Chlamydomonas reinhardtii@PRO_jgi_Chlre3_181993[RRM1]
Eumetazoa@PRO_ENSDNOP00000008593[244][RRM1:100%*****][P54nrb:38%****][.PSP1:16%***][.PSF:16%***][KOG0115:99%*****]Cyanidioschyzon merolae@PRO_gnl_CMER_CML202C[RRM1][put-sr]
Cyanidioschyzon merolae@PRO_gnl_CMER_CMO246C[RRM2][KOG0110]Eukaryota@PRO_IMGA_AC183923_6_1[89][RRM3:70%****][.RRM2:17%**][.RRM1:13%**][put-sr:6%*][KOG0110:100%****]
Thalassiosira pseudonana@PRO_jgi_Thaps3_268689[RRM2][KOG0110]Arabidopsis thaliana@SMA_O49430_ARATH[4][RRM1:100%*][KOG0117:50%][.KOG0127:25%]
eurosids_I@PRO_IMGA_CT963106_6_1[2][RRM1:100%][KOG0117:50%]Trypanosomatidae@PRO_XP_001463723[11][RRM1:82%**][.RRM2:18%][KOG0110:100%**]
Oryza sativa_japonica_cultivar-group@PRO_NP_001053839[3][RRM1:67%][.RRM2:33%][KOG0110:100%*]Phytophthora@PRO_jgi_Physo1_1_129427[2][RRM2:100%][KOG0110:100%]
Caenorhabditis@PRO_T23F6_4_1[6][RRM3:67%*][.RRM2:33%][KOG0110:100%*]Ascomycota@PRO_NP_984131[38][RRM2:100%***][KOG0110:100%***]
Schizosaccharomyces_pombe@PRO_NP_595599[3][RRM2:100%*][KOG0110:100%*]Sordariales@PRO_XP_965014[5][RRM2:100%*][KOG0110:100%*]
Sclerotiniaceae@REF_XP_001548634[2][RRM2:100%][KOG0110:100%]Magnaporthe grisea_70-15@REF_XP_363291[2][RRM2:100%][KOG0110:100%]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_20740[RRM2][KOG0110]Filobasidiella_neoformans@PRO_XP_569873[4][RRM2:75%*][.RRM1:25%][KOG0110:100%*]
Ustilago_maydis@PRO_XP_758493[3][RRM2:100%*][KOG0110:100%*]Entamoeba_histolytica@REF_XP_655058[3][RRM2:100%*][KOG0110:67%][.KOG0123:33%]
Trichomonas vaginalis_G3@REF_XP_001324476[RRM2][KOG0110]Acaryochloris marina_MBIC11017@REF_YP_001521497[RRM1][PROK][KOG0111]
Synechococcus@PRO_YP_473618[6][RRM1:100%*][PROK:100%*][KOG0108:100%*]Piroplasmida@REF_XP_001611590[6][RRM2:100%*][KOG0117:33%][.KOG0116:17%]
Chlamydomonadales@PRO_jgi_Volca1_90315[3][RRM2:67%][.RRM3:33%][KOG0123:67%]Entamoeba histolytica_HM-1_IMSS@REF_XP_653167[3][RRM1:100%*][KOG4209:100%*]
Caenorhabditis briggsae@REF_XP_001678677[RRM1]Entamoeba histolytica_HM-1_IMSS@REF_XP_655803[2][RRM2:100%][KOG0148:100%]
Dictyostelium discoideum_AX4@PRO_XP_643642[3][RRM2:100%*][KOG0148:100%*]Cryptosporidium@PRO_XP_001388131[4][RRM2:100%*][KOG0117:50%][.KOG1015:50%]
Ostreococcus@PRO_jgi_Ost9901_3_27365[3][RRM1:100%*][KOG0123:67%]Strongylocentrotus purpuratus@SMA_UPI0000587E0B[RRM3][KOG0116]
Strongylocentrotus purpuratus@SMA_UPI0000587E0B[RRM1][KOG0116]Ciona@PRO_ENSCSAVP00000005375[6][RRM2:83%*][.RRM1:17%][KOG0116:83%*][.KOG2141:17%]
31
32 33 - p54nrb
PSP1
PSF
35 - G3BP
RBM
30K RRM
hnRNP
Musashi
Dazap
TARDBP
OligoU
Fig. S9
127
52
58
79
100
53 60
59
58
54
93
53
95
77 87
Chlamydomonadales@SMA Q39568 CHLRE[3][RRM2:100%*][KOG0108:67%][ KOG4212:33%]Giardia lamblia_ATCC_50803@SMA_Q7R0B6_GIALA[RRM1][put-sr][KOG0127]
Trypanosomatidae@SMA_Q4FWP9_LEIMA[11][RRM2:100%**][KOG4212:100%**]Saccharomycetaceae@PRO_XP_462023[6][RRM1:100%*][put-sr:83%*][KOG0123:100%*]
Saccharomycetales@PRO_XP_446962[16][RRM1:100%**][put-sr:62%**][KOG0123:50%**][.KOG0127:50%**]Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_34965[2][RRM1:100%][KOG4212:100%]
Trypanosomatidae@PRO_XP_001465100[11][RRM1:100%**][KOG4212:100%**]Chlamydomonadales@PRO_jgi_Chlre3_184854[2][RRM1:100%][KOG0055:50%]
Bacillariophyta@PRO_jgi_Phatr2_7426[2][RRM1:100%]Volvox carteri@PRO_jgi_Volca1_103054[RRM2][KOG0055]
Filobasidiella_neoformans@REF_XP_773466[5][RRM1:100%*][put-sr:100%*][KOG0147:100%*]Trypanosomatidae@PRO_XP_823301[5][RRM1:100%*][KOG0921:60%*]
Nematostella vectensis@REF_XP_001637595[RRM1][put-sr][KOG4212]Strongylocentrotus purpuratus@PRO_XP_001187716[9][RRM1:100%**][put-sr:89%**][KOG4212:56%*][.KOG4661:44%*]
Schistosoma japonicum@SMA_Q5DC86_SCHJA[RRM1][put-sr][KOG4212]Coelomata@SMA_UPI00005A3D66[197][RRM1:100%*****][hnRNP:39%****][KOG4212:100%*****]Caenorhabditis@SMA_Q9XVS2_CAEEL[2][RRM1:100%][put-sr:100%][KOG4212:100%]
Bilateria@PRO_XP_967263[124][RRM2:82%****][.RRM1:18%***][put-sr:85%****][SR:77%****][KOG0105:100%****]Plasmodium falciparum_3D7@PRO_XP_001347501[RRM2][put-sr][KOG0105]
Theileria@PRO_XP_766386[3][RRM2:100%*][put-sr:100%*][KOG0105:100%*]Fungi/Metazoa_group@REF_XP_001623720[290][RRM2:86%*****][.RRM1:13%***][put-sr:100%*****][SR:59%*****][KOG0105:52%*****][.KOG0106:44%****]
Phytophthora@PRO_jgi_Physo1_1_136493[2][RRM2:100%][put-sr:100%][KOG0105:100%]Phytophthora ramorum@PRO_jgi_Phyra1_1_84100[RRM2][KOG0105]
Plasmodium@PRO_XP_001347332[6][RRM2:100%*][put-sr:83%*][KOG0105:100%*]Babesia bovis@REF_XP_001610592[RRM2][KOG0123]
Theileria@PRO_XP_766728[5][RRM2:100%*][KOG0124:100%*]Nematostella vectensis@REF_XP_001637595[RRM3][put-sr][KOG4212]
Cyanidioschyzon merolae@PRO_gnl_CMER_CMM078C[RRM2][KOG4212]Chordata@PRO_ENSOGAP00000002890[198][RRM3:79%*****][.RRM2:14%***][.RRM1:7%**][hnRNP:45%****][KOG4212:100%*****]
Strongylocentrotus purpuratus@PRO_XP_786244[5][RRM3:100%*][put-sr:80%*][KOG4212:100%*]Endopterygota@REF_XP_001657115[16][RRM3:100%**][hnRNP:6%][KOG4212:100%**]
Caenorhabditis@REF_XP_001668553[3][RRM3:100%*][put-sr:100%*][KOG4212:100%*]Theileria@REF_XP_763694[4][RRM2:100%*][KOG4212:100%*]
Babesia bovis@REF_XP_001610597[RRM2][KOG4212]Dikarya@PRO_XP_568231[30][RRM3:90%***][.RRM2:10%*][put-sr:83%***][KOG4212:90%***][.KOG0147:10%*]
Yarrowia lipolytica@PRO_XP_503927[3][RRM3:100%*][put-sr:100%*][KOG4212:100%*]Saccharomycetales@REF_XP_001483552[11][RRM3:55%*][.RRM2:45%*][put-sr:45%*][KOG0123:64%*][.KOG4212:36%*]
Kluyveromyces lactis@PRO_XP_453283[3][RRM2:100%*][KOG0123:100%*]Saccharomycetales@PRO_YNL004W[14][RRM3:93%**][.RRM2:7%][put-sr:50%*][KOG0123:57%**][.KOG0127:36%*]
Eukaryota@SMA_Q5B6U1_EMENI[102][RRM1:65%****][.RRM2:35%***][put-sr:45%***][KOG4212:86%****][.KOG0123:7%*][.KOG0147:5%*]Candida_glabrata@PRO_XP_446962[3][RRM2:100%*][put-sr:100%*][KOG0127:100%*]
Plasmodium@REF_XP_746250[10][RRM2:90%**][.RRM1:10%][KOG4212:90%**]Schizosaccharomyces pombe_972h-@PRO_NP_594207[2][RRM2:100%][KOG4212:100%]Schizosaccharomyces pombe@SMA_Q9P3U1_SCHPO[RRM2][KOG4212]
Nematostella vectensis@REF_XP_001637595[RRM2][put-sr][KOG4212]Schistosoma japonicum@SMA_Q5DC86_SCHJA[RRM2][put-sr][KOG4212]
Caenorhabditis@PRO_C25A1_4_2[5][RRM2:100%*][put-sr:100%*][KOG4212:100%*]Coelomata@PRO_ENSMLUP00000006206[233][RRM2:88%*****][.RRM1:12%***][hnRNP:36%****][KOG4212:98%*****]
Arabidopsis thaliana@PRO_NP_179762[3][RRM1:100%*][oligoU:100%*]Nematostella vectensis@REF_XP_001627235[RRM1]Phytophthora@PRO_jgi_Physo1_1_141766[2][RRM1:100%][KOG0148:100%]
Guillardia theta@SMA_Q5K249_GUITH[RRM1][KOG0149]Phytophthora@PRO_jgi_Physo1_1_134615[2][RRM1:100%]
Plesiocystis pacifica_SIR-1@REF_ZP_01910335[RRM1][PROK][KOG0921]Chlamydomonadales@PRO_jgi_Volca1_107658[2][RRM1:100%][KOG4205:50%][.KOG0474:50%]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_21039[RRM2][KOG4205]Arabidopsis thaliana@PRO_NP_173298[3][RRM1:100%*][GRSRBP:100%*][KOG0149:100%*]
Oryza sativa_japonica_cultivar-group@SMA_Q8LLX3_ORYSA[RRM1][KOG0148]Magnoliophyta@PRO_NP_001059075[15][RRM1:100%**][put-sr:7%][GRSRBP:53%**][KOG0108:47%*][.KOG0148:33%*][.KOG0111:20%*]
Sorghum bicolor@SMA_GRP1_SORBI[RRM1][GRSRBP][KOG0921]Oryza sativa@SMA_O04432_ORYSA[RRM1][put-sr][KOG0921]
Arabidopsis thaliana@SMA_Q1PES4_ARATH[4][RRM1:100%*][30kRRM:100%*][KOG0149:100%*]Eukaryota@PRO_NP_001058102[212][RRM1:100%*****][RBM:55%****][.30kRRM:17%***][KOG0149:95%*****]
Arabidopsis thaliana@PRO_NP_200183[6][RRM1:100%*][oligoU:100%*][KOG0149:100%*]Phytophthora sojae@PRO_jgi_Physo1_1_139371[RRM2][KOG4205]
Phytophthora sojae@PRO_jgi_Physo1_1_139371[RRM1][KOG4205]Magnoliophyta@SMA_UPI000017A786[34][RRM1:100%***][oligoU:68%***][KOG4205:59%**][.KOG0149:32%**][.KOG2186:9%*]
Oryza_sativa@SMA_Q7XTU5_ORYSA[3][RRM1:100%*][KOG4205:100%*]Oryza sativa_japonica_cultivar-group@SMA_Q2R1J0_ORYSA[RRM1][KOG0148]
Cyanidioschyzon merolae@PRO_gnl_CMER_CMR392C[RRM2][KOG4205]Ostreococcus tauri@PRO_jgi_Ostta4_33731[RRM1]
Ostreococcus tauri@PRO_jgi_Ostta4_33731[RRM2]Aureococcus anophagefferens@PRO_jgi_Auran1_66158[RRM2][put-sr][KOG0149]
Oryza sativa_japonica_cultivar-group@SMA_UPI00000A9C56[2][RRM1:100%][KOG4205:100%]Oryza sativa_japonica_cultivar-group@SMA_Q8GW06_ORYSA[RRM1]
Strongylocentrotus purpuratus@PRO_XP_798256[5][RRM1:100%*][KOG2277:100%*]Xenopus@PRO_ENSXETP00000012439[3][RRM1:100%*][KOG2277:100%*]
Eutheria@SMA_Q5RE94_PONPY[12][RRM1:100%**][KOG2277:100%**]Percomorpha@PRO_ENSORLP00000005442[3][RRM1:100%*][KOG2277:100%*]
Danio rerio@SMA_Q4KMD7_BRARE[RRM1][KOG2277]Oryza sativa_japonica_cultivar-group@PRO_NP_001058805[3][RRM1:100%*][KOG4205:100%*]
Oryza sativa_japonica_cultivar-group@SMA_Q6AU49_ORYSA[4][RRM1:100%*][KOG0149:75%*][.KOG4205:25%]Zea mays@PRO_14684_m000016_AZM5_14964[RRM1][KOG4205]
Ricinus communis@PRO_28976_m000161[RRM1][KOG4205]Piroplasmida@REF_XP_764402[5][RRM1:100%*][KOG4205:100%*]
Ricinus communis@PRO_30170_m013671[RRM1][KOG4205]Arabidopsis thaliana@SMA_Q9SM01_ARATH[3][RRM1:100%*][KOG4205:100%*]
Embryophyta@PRO_jgi_Phypa1_1_156290[11][RRM1:100%**][put-sr:27%*][KOG4205:100%**]Arabidopsis thaliana@SMA_O23189_ARATH[RRM1][KOG4205]
Chlamydomonadales@PRO_jgi_Chlre3_105806[2][RRM1:100%][KOG4205:100%]Nematostella vectensis@REF_XP_001637003[RRM1][KOG4205]
Coelomata@PRO_ENSMLUP00000003881[137][RRM1:100%****][TARDBP:66%****][KOG4205:97%****]Caenorhabditis@SMA_Q20414_CAEEL[2][RRM1:100%][KOG4205:100%]
Strongylocentrotus purpuratus@SMA_UPI00005846A2[6][RRM1:100%*][KOG4205:100%*]Ciona@PRO_ENSCINP00000012771[9][RRM1:100%**][put-sr:11%][KOG4205:100%**]Bilateria@SMA_UPI0000D6301C[874][RRM1:100%******][hnRNP:57%******][KOG4205:100%******]
Cryptosporidium@SMA_Q5CKR7_CRYHO[5][RRM2:100%*][KOG0144:100%*]Plasmodium_falciparum_3D7@SMA_Q8I2Y5_PLAF7[9][RRM2:100%**][KOG0144:100%**]
Cryptosporidium@SMA_Q5CM52_CRYHO[5][RRM2:100%*][KOG4205:100%*]Takifugu rubripes@SMA_UPI000065CE8D[RRM3][KOG4205]
Aureococcus anophagefferens@PRO_jgi_Auran1_9354[RRM1]Ornithorhynchus anatinus@REF_XP_001521058[RRM1]
Tribolium castaneum@PRO_XP_970765[3][RRM1:100%*][KOG0127:100%*]Aureococcus anophagefferens@PRO_jgi_Auran1_9576[RRM1][KOG0149]
Chlamydomonadales@PRO_jgi_Volca1_107445[2][RRM1:100%][KOG4205:100%]Cyanidioschyzon merolae@PRO_gnl_CMER_CMR392C[RRM1][KOG4205]
Nematostella vectensis@REF_XP_001628585[RRM1][KOG4205]Thalassiosira pseudonana@PRO_jgi_Thaps3_25203[2][RRM1:100%][KOG4205:100%]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_41450[RRM1][KOG4205]Ciona intestinalis@PRO_ENSCINP00000029053[2][RRM1:100%][KOG4205:100%]
Ciona intestinalis@PRO_ENSCINP00000006182[RRM1][KOG4205]Ustilago maydis_521@SMA_Q4PBU3_USTMA[3][RRM2:100%*][KOG4205:100%*]
Takifugu rubripes@SMA_UPI000065DA3A[RRM1][KOG0149]Takifugu rubripes@SMA_UPI000065FE7B[RRM1][KOG0149]
Takifugu rubripes@SMA_UPI000065F126[4][RRM1:100%*][KOG0149:100%*]Mus musculus@SMA_UPI0000D66F4E[RRM1][RBM][KOG0149]
Eukaryota@REF_XP_665248[7][RRM1:100%*][KOG4205:100%*]Cryptosporidium@PRO_XP_626025[4][RRM1:100%*][KOG4205:100%*]Chlamydomonadales@PRO_jgi_Volca1_121254[2][RRM2:100%][KOG4205:100%]
Strongylocentrotus purpuratus@PRO_NP_999784[8][RRM1:100%**][KOG4205:100%**]
34
29 - dual-RRM
SR proteins
30 - hnRNP
PDIP
FCA FPA
Fig. S9
128
0.20
52
55
83
78
50
77 54
57
Leptospira@PRO_YP_001385[9][RRM1:100%**][PROK:100%**]Pelobacter carbinolicus_DSM_2380@PRO_YP_357907[3][RRM1:100%*][PROK:100%*][KOG0145:100%*]
Desulfuromonadales@PRO_NP_952377[14][RRM1:100%**][PROK:100%**][KOG0108:43%*][.KOG0145:21%*][.KOG0111:7%][.KOG4207:7%]Pedobacter sp._BAL39@REF_ZP_01882661[RRM1][PROK][KOG0108]
Aureococcus anophagefferens@PRO_jgi_Auran1_60739[RRM1][put-sr][KOG1860]Microscilla marina_ATCC_23134@REF_ZP_01693505[RRM1][PROK][KOG0148]
Vibrio fischeri_ES114@PRO_YP_206444[3][RRM1:100%*][PROK:100%*][KOG0145:100%*]Gammaproteobacteria@REF_ZP_01476992[67][RRM1:100%****][PROK:100%****][KOG0144:21%**][.KOG0108:19%**][.KOG0145:18%**][.KOG0122:9%*]
Dictyostelium discoideum_AX4@PRO_XP_638767[3][RRM1:100%*][KOG0123:100%*]Bacteroides@PRO_YP_001298723[7][RRM1:100%*][PROK:100%*][KOG0108:100%*]
Bacteroidales@PRO_YP_001302325[6][RRM1:100%*][PROK:100%*][KOG0122:67%*][.KOG0123:33%]Methanomicrobiales@PRO_YP_001047169[14][RRM1:100%**][PROK:100%**][KOG0108:43%*][.KOG0116:21%*][.KOG0125:14%]
Ostreococcus tauri@PRO_jgi_Ostta4_19468[RRM1][KOG0127]Oryza sativa_japonica_cultivar-group@SMA_Q6ERT8_ORYSA[RRM1]
Ostreococcus@PRO_jgi_Ost9901_3_12693[3][RRM2:100%*][KOG0127:100%*]Nematostella vectensis@REF_XP_001621824[5][RRM1:100%*][KOG0108:100%*]
Phytophthora@PRO_jgi_Phyra1_1_75647[2][RRM1:100%]Nematostella vectensis@REF_XP_001627237[RRM1][KOG0921]
Proteobacteria@PRO_YP_844222[3][RRM1:100%*][PROK:100%*][KOG0108:100%*]Carboxydothermus hydrogenoformans_Z-2901@SMA_Q3AF33_CARHZ[3][RRM1:100%*][PROK:100%*][KOG0108:100%*]
cellular_organisms@SMA_Q41VF2_DESHA[1326][RRM1:95%*******][.RRM2:5%****][PROK:39%******][put-sr:17%*****][GRSRBP:12%*****][.hnRNP:6%****][.RBMY:5%****][KOG0108:34%******][.KOG0149:11%*****][.KOG0111:10%****][.KOG0116:7%****][.KOG0117:5%****][.KOG0125:5%****]Chloroflexus@SMA_Q3DVT1_CHLAU[5][RRM1:100%*][PROK:100%*][KOG0149:60%*][.KOG0108:40%]
Comamonas testosteroni_KF-1@REF_ZP_01521959[2][RRM1:100%][PROK:100%][KOG0108:50%][.KOG0123:50%]Volvox carteri@PRO_jgi_Volca1_36996[RRM1][KOG0116]Ostreococcus@PRO_jgi_Ost9901_3_34381[3][RRM1:100%*][KOG0145:100%*]
Cyanobacteria@PRO_YP_476186[31][RRM1:100%***][PROK:100%***][KOG0108:32%**][.KOG0122:10%*]Cyanobacteria@PRO_NP_898344[50][RRM1:100%***][PROK:100%***][KOG0108:76%***]
Synechococcus_elongatus@PRO_YP_399809[6][RRM1:100%*][PROK:100%*][KOG0108:100%*]Magnoliophyta@PRO_NP_001060859[12][RRM1:100%**][cpRNP:50%*][KOG0148:42%*][.KOG0110:33%*][.KOG0225:8%]
Magnoliophyta@SMA_Q9FYW5_LYCES[14][RRM1:100%**][put-sr:79%**][snRNP:79%**][KOG0120:100%**]Chlamydomonas reinhardtii@PRO_jgi_Chlre3_145376[RRM2]
Alkalilimnicola ehrlichei_MLHE-1@PRO_YP_741458[3][RRM1:100%*][PROK:100%*]Proteobacteria@SMA_UPI00005F3438[101][RRM1:100%****][PROK:100%****][KOG0108:90%****]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_38474[RRM1]Chlamydomonas reinhardtii@PRO_jgi_Chlre3_174860[RRM2][KOG1240]
Trypanosoma@REF_XP_818775[6][RRM1:100%*]Mariprofundus ferrooxydans_PV-1@REF_ZP_01453708[RRM1][PROK][KOG0108]
Magnoliophyta@PRO_NP_001062073[9][RRM1:100%**][KOG0110:67%*][.KOG0127:33%*]Oryza_sativa@SMA_Q5VSX4_ORYSA[4][RRM1:100%*][KOG0127:75%*]
rosids@PRO_30054_m000821[6][RRM1:100%*][cpRNP:50%*][KOG0127:100%*]Trichomonas vaginalis_G3@REF_XP_001580806[RRM1]
Schizosaccharomyces_pombe@PRO_NP_596721[3][RRM3:100%*][KOG0128:100%*]Trichomonas vaginalis_G3@REF_XP_001325677[2][RRM1:100%][KOG1924:50%]
Schizosaccharomyces_pombe@PRO_NP_596721[3][RRM2:100%*][KOG0128:100%*]Pezizomycotina@SMA_Q01491_OPHUL[15][RRM2:93%**][.RRM1:7%][KOG0128:93%**][.KOG0123:7%]
Ustilago maydis_521@SMA_Q4PC71_USTMA[RRM1][KOG0123]Pichia guilliermondii_ATCC_6260@REF_XP_001485760[RRM2][KOG0123]
Debaryomyces_hansenii@SMA_Q6BM90_DEBHA[3][RRM2:67%][.RRM1:33%][KOG0128:100%*]Eremothecium gossypii@SMA_Q756X0_ASHGO[RRM1][KOG0128]
Saccharomyces cerevisiae@PRO_YMR268C[2][RRM2:100%][KOG0128:100%]Ustilago maydis_521@PRO_XP_761797[3][RRM1:100%*][put-sr:100%*][KOG3257:100%*]Magnoliophyta@PRO_NP_566958[15][RRM2:73%**][.RRM1:27%*][KOG0124:40%*][.KOG0131:33%*][.KOG0123:13%][.KOG0148:7%]
Oryza sativa_japonica_cultivar-group@SMA_Q69UI3_ORYSA[3][RRM2:100%*][KOG0110:100%*]rosids@SMA_Q9MAM6_ARATH[7][RRM2:100%*][cpRNP:86%*][KOG0148:71%*][.KOG0110:14%][.KOG0225:14%]
Aureococcus anophagefferens@PRO_jgi_Auran1_6342[RRM2][KOG0123]Magnoliophyta@PRO_29333_m001057[10][RRM2:90%**][.RRM1:10%][cpRNP:30%*][KOG0131:80%**][.KOG0127:10%][.KOG0148:10%]
Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_27365[2][RRM3:100%][KOG0123:100%]Chlamydomonadales@PRO_jgi_Volca1_103054[2][RRM3:50%][.RRM2:50%][KOG0055:50%]
Aureococcus anophagefferens@PRO_jgi_Auran1_8994[RRM1][KOG0149]Entamoeba histolytica_HM-1_IMSS@REF_XP_655048[2][RRM2:100%][put-sr:100%][KOG0123:100%]
Dictyostelium discoideum_AX4@PRO_XP_638767[3][RRM2:100%*][KOG0123:100%*]Magnoliophyta@PRO_IMGA_AC119413_25_2[9][RRM2:100%**][cpRNP:33%*][KOG0127:100%**]
Poaceae@PRO_19213_m000022_AZM5_85721[4][RRM2:75%*][.RRM1:25%][KOG0127:75%*]Ricinus communis@PRO_29908_m006094[RRM2][KOG0110]
Arabidopsis thaliana@PRO_NP_192643[6][RRM2:83%*][.RRM1:17%][KOG0110:83%*]Magnoliophyta@PRO_10511_m000028_AZM5_5258[52][RRM1:100%***][cpRNP:29%**][KOG0127:56%***][.KOG0131:33%**][.KOG0145:10%*]
Magnoliophyta@SMA_O81989_HORVU[10][RRM1:100%**][cpRNP:30%*][KOG0131:80%**][.KOG0127:10%]Embryophyta@PRO_jgi_Phypa1_1_134646[17][RRM1:100%**][cpRNP:18%*][KOG0123:59%**][.KOG0127:24%*][.KOG0144:6%][.KOG2029:6%]
Magnoliophyta@SMA_Q6H443_ORYSA[11][RRM1:100%**][KOG0124:55%*][.KOG0131:45%*]Cryptococcus_neoformans_var._neoformans@PRO_XP_572539_RRM
Saccharomycetales@PRO_XP_001386572[28][RRM2:68%**][.RRM1:32%**][put-sr:43%**][KOG0123:64%**][.KOG0127:18%*][.KOG4212:14%*]Yarrowia lipolytica@PRO_XP_505184[3][RRM1:100%*]
Trichocomaceae@REF_XP_001388936[8][RRM1:100%**]Coccidioides immitis_RS@REF_XP_001245337[RRM1][put-sr]
Ajellomyces capsulatus_NAm1@REF_XP_001540919[RRM2]Ostreococcus_lucimarinus@PRO_jgi_Ost9901_3_34965[2][RRM2:100%][KOG4212:100%]
Phytophthora@PRO_jgi_Phyra1_1_75500[2][RRM3:100%][KOG0123:100%]Thalassiosira pseudonana@PRO_jgi_Thaps3_37126[RRM2][KOG0123]
Phaeodactylum tricornutum@PRO_jgi_Phatr2_51303[RRM2][KOG4212]Chlamydomonadales@PRO_jgi_Volca1_78979[3][RRM1:100%*][KOG3070:100%*]Chlamydomonadales@SMA_Q39568_CHLRE[3][RRM2:100%*][KOG0108:67%][.KOG4212:33%]
88 - prokaryotic RRMs
Fig. S9
129
RRM1 hnRNPr (land plants)
RRM4/5 RBP
RRM4/5/6 RBP
RRM1 CID1RRM1 Rasputin + RRM1 SEB4 + RRM1/2 HRP1
RRM1 SART3 (excl. green plants)
RRM1 SART3 (green plants)
RRM1 U1 snRNPRRM2 SART3[RRM1 peptidyl-prolyl cis-trans isomerase]
RRM2 U1A/U2B snRNP
RRM2 Mei2[RRM1 RBP]
RRM1/2/3 hnRNPm [+RRM1 RRM-containing protein]RRM2 dual RRM SR proteins (excl. plants)
RRM1 LARK
RRM2 dual RRM of plant-specific RS group of SR proteins
RRM1 CAPER/UMH
RRM1 U1A/U2B snRNP
RRM2 U2AF
RRM1 predicted RBP
RRM1 TIF3/eIF3
RRM3 hnRNPr
RRM1 NIFK
RRM1 RBP La
RRM1 RBP
RRM1 splicing factor 2bRRM1 RBP
RRM4 RBP
RRM2 splicing factor SR rich
RRM1 fibrillarin
RRM2 fibrillarin
RRM3 fibrillarin[RRM1 RBP p54 nrb]
RRM3 RBPRRM1 hnRNPr (flowering plants)
RRM1 single RRM SR proteins
[RRM1 cyclophilin-type peptidyl-prolyl cis-trans isomerase][RRM1 RBP RBM8]
[RRM1 CBP20]
RRM? fusillin + RRM2 hnRNPf
RRM2 PUF60 + RRM2 CAPER/UMH [+ RRM1 PUF60]
RRM1 ataxin-2 binding-protein + RRM1 fibrillarin (land plants) + RRM1 SAF-B
RRM2 TIA1/TIAR + RRM1 RBP
RRM1 RBP
RRM1 PABPRRM2 PABP + RRM2 splicing factor 2b (fungi) [+ RRM2 RBP p54 nrb]RRM3 PABP (minor subgroup)RRM4 PABPRRM1 BRUNORRM2 BRUNORRM3 BRUNORRM1 ELAV/HURRM2 ELAV/HURRM3 ELAV/HU
RRM1 hnRNPr (excl. flowering plants)
[RRM1 RBP][RRM1 predicted splicing regulator]
16
17
42
1
2
3
4
5
6
7
8
9
10
11
12
81
13
14
15
19
24
20
29
30
3132
33
34
35
36
37
3839
40
41
44
45
46
4749
50
5152
55
56
59
60
61
62
64
65
67
68
69
70
71
72
73
74
80
82
83
84
85
87
53
54 RRM3 RBP
75
77
RRM1 splicing factor RNPS1
86
prokaryotic RRMs
63
RRM1 Mei243
RRM1 dual RRM SR proteins[RRM1 single RRM Zn-K SR proteins]
RRM1 cyclophilin-type peptidyl-prolyl cis-trans isomerase (SRrp)
1821
22
2325
RRM1 SR45 (green plants)RRM1 splicing factor RNPS1
26
2728
[RRM1 IGF2BP]48
RRM2 RBP
RRM2 LARK
RRM1 RNA15/ZCRB1
RRM1 RNA15/hnRNP/GRSRBP/RBMY
57
58
RRM3 PABP (major subgroup)66
RRM1 TIA1/TIAR76
RRM3 TIA1/TIAR78
RRM3 TIA1/TIAR79
RRM1 hnRNP/RALYL
RRM1 eIF4B
88
= RRM1 of SR proteins
Fig. S10
130
56 RRM2 dual RRM of plant-specific RS group of SR proteins
30b PDIP/FCA/FPA
30a RRM1/2/3 hnRNPm
29 RRM2 dual RRM SR proteins (excl. plants)
24 RRM1 CBP20
misc
misc
22b RRM1 single RRM SR proteins (animals)
22a RRM1 single RRM SR proteins (plants)
23 RRM1 SRrp
20 RRM1 RBP RBM8
27 RRM1 splicing factor RNPS1
26 RRM1 SR45
17 RRM1 single RRM Zn-K SR proteins
16 RRM1 dual RRM SR proteins
57 RRM1 RNA15/ZCRB1
56 RRM2 dual RRM of plant-specific RS group of SR proteins
24 RRM1 CBP20
30b PDIP/FCA/FPA
30a RRM1/2/3 hnRNPm
29 RRM2 dual RRM SR proteins (excl. plants)
22b RRM1 single RRM SR proteins (animals)
42 RRM1 Mei2
22a RRM1 single RRM SR proteins (plants)
23 RRM1 SRrp
20 RRM1 RBP RBM8
19 RRM1 cyclophilin-type peptidyl-prolyl cis-trans isomerase
misc
16b RRM1 dual RRM SR proteins
17 RRM1 single RRM Zn-K SR proteins
16a RRM1 dual RRM SR proteins
misc
27 RRM1 splicing factor RNPS1
26 RRM1 SR45
67 RRM2 CAPER/UMH
43 RRM2 Mei2
40 RRM1 U1A/U2B snRNP
56 RRM2 dual RRM of plant-specific RS group of SR proteins
37 RRM2 SART3
38 RRM1 peptidyl-prolyl cis-trans isomerase (cyclophilin)
36 RRM1 U1 snRNP
30 RRM1/2/3 hnRNPm / PDIP/FCA/FPA
29 RRM2 dual RRM SR proteins (excl. plants)
84 RRM1 RBP La
27 RRM1 splicing factor RNPS1
26 RRM1 SR45
71 RRM2 fibrillarin (RBM)
20 RRM1 RBP RBM8
24 RRM1 CBP20
17 RRM1 single RRM Zn-K SR proteins
22a RRM1 single RRM SR proteins (plants)
23 RRM1 SRrp
22b RRM1 single RRM SR proteins (animals)
42 RRM1 Mei2
33 RRM1 RBP p54 nrb
54 RRM3 RBP
53 RRM2 RBP
16 RRM1 dual RRM SR proteins
20 RRM1 RBP RBM8
27 RRM1 splicing factor RNPS1
26 RRM1 SR45
71 RRM2 fibrillarin (RBM)
63 RRM3 hnRNPr
56 RRM2 dual RRM of plant-specific RS group of SR proteins
30b PDIP/FCA/FPA
30a RRM1/2/3 hnRNPm
29 RRM2 dual RRM SR proteins (excl. plants)
22b RRM1 single RRM SR proteins (animals)
65 RRM1 TIF3/eIF3
24 RRM1 CBP20
22a RRM1 single RRM SR proteins (plants)
23 RRM1 SRrp
17 RRM1 single RRM Zn-K SR proteins
16 RRM1 dual RRM SR proteins
71 RRM2 fibrillarin (RBM)63 RRM3 hnRNPr
41 RRM2 U1A/U2B snRNP
56 RRM2 dual RRM of plant-specific RS group of SR proteins
30 RRM1/2/3 hnRNPm / PDIP/FCA/FPA
29 RRM2 dual RRM SR proteins (excl. plants)
22b RRM1 single RRM SR proteins (animals)
24 RRM1 CBP20
27 RRM1 splicing factor RNPS1
26 RRM1 SR45
22a RRM1 single RRM SR proteins (plants)
23 RRM1 SRrp
17 RRM1 single RRM Zn-K SR proteins
43 RRM2 Mei2
16 RRM1 dual RRM SR proteins
C TREEFINDER (WAG+!4)
B RAXML (WAG+!4)
D RAXML (LG+F+!4)
E large RAXML (WAG+!4)
57 RRM1 RNA15/ZCRB1
34 RRM1 CID1
misc
A PAUP* (MP)
Fig. S11
131
0.25
36
57
56
34 21
7
1
1
7
30
97 56
16
29
11 3
6
8
39 4
6
59
13 18
8
32 14
6
1
18
48 13
2
1
27 18
28 2
33
38
8
13
3
20 6
31
18
1
3
47
1
62
45 38
6
2
1
13
8
26
84
9
7
18
12
19 24
40 48
6
2 1
14
19 1
4 1
48
5
67 4
52 6
24
7
16
3
38
2
2
cellular_organisms@YP_001113853[137][RRM1:100%****][PROK:99%****][KOG0108:58%****][.KOG0116:14%**][.KOG0921:7%**][.KOG0149:7%**][.KOG0111:6%**]
Bacteroidales@YP_213478[13][RRM1:100%**][PROK:100%**][KOG0108:69%**][.KOG0125:31%*]
Embryophyta@jgi_Phypa1_1_28366[17][RRM1:100%**][put-sr:76%**][KOG0127:29%*][.KOG0125:12%][.KOG4661:6%][.KOG0147:6%]
Coelomata@ENSTBEP00000011040[87][RRM1:98%****][put-sr:16%**][KOG4661:100%****]
Gammaproteobacteria@YP_561253[27][RRM1:100%***][PROK:100%***][KOG0108:96%***]
Embryophyta@jgi_Phypa1_1_134646[11][RRM1:100%**][cpRNP:9%][KOG0123:45%*][.KOG0127:36%*][.KOG2029:9%]
Magnoliophyta@10511_m000028_AZM5_5258[15][RRM1:100%**][cpRNP:33%*][KOG0127:53%**][.KOG0131:27%*][.KOG0145:13%][.KOG0108:7%]
Coelomata@ENSTBEP00000015452[229][RRM3:88%*****][.RRM2:9%**][ELAV:82%*****][KOG0145:100%*****]
Embryophyta@NP_001063403[14][RRM1:100%**][KOG0148:100%**]
Cyanobacteria@YP_476186[8][RRM1:100%**][PROK:100%**][KOG0108:38%*][.KOG0122:12%]
Cyanobacteria@NP_898344[17][RRM1:100%**][PROK:100%**][KOG0108:65%**]
Coelomata@ENSORLP00000004891[62][RRM2:94%****][.RRM1:6%*][RBMS:79%***][KOG0145:100%****]
Bilateria@ENSORLP00000014121[125][RRM1:100%****][FOX:75%****][KOG0125:100%****]
Euteleostomi@ENSOANP00000001262[28][RRM1:100%***][RBM:46%**][KOG0127:100%***]
Eukaryota@NP_187747[49][RRM1:100%***][KOG0122:98%***]
Coelomata@ENSMLUP00000006206[100][RRM2:88%****][.RRM1:12%**][put-sr:5%*][hnRNP:28%***][KOG4212:98%****]
Chordata@ENSOGAP00000002890[91][RRM3:80%****][.RRM2:13%**][.RRM1:7%*][hnRNP:37%***][KOG4212:100%****]
Coelomata@ENSOGAP00000009767[86][RRM1:100%****][hnRNP:34%***][KOG4212:100%****]
Eukaryota@jgi_Volca1_109965[18][RRM1:78%**][.RRM2:22%*][put-sr:22%*][KOG4212:61%**][.KOG0123:39%*]
Fungi_Metazoa_group@AGAP004592-PA[123][RRM2:81%****][.RRM1:18%***][put-sr:100%****][SR:60%****][KOG0105:50%****][.KOG0106:46%****]
Bilateria@XP_967263[73][RRM2:78%****][.RRM1:22%**][put-sr:79%****][SR:75%****][KOG0105:100%****]
Euteleostomi@ENSDNOP00000001522[23][RRM1:100%***][RBM:61%**][KOG0144:87%**][.KOG0145:13%*]
Eukaryota@ENSDNOP00000002400[249][RRM4:82%*****][.RRM3:11%***][.RRM2:6%**][PABP:54%****][KOG0123:100%*****]
Eukaryota@XP_964958[72][RRM1:100%****][KOG0226:100%****]
Eukaryota@ENSETEP00000015606[204][RRM3:85%*****][.RRM2:11%***][PABP:66%****][KOG0123:100%*****]
Eukaryota@ENSGALP00000021793[59][RRM1:100%****][cyclophilin:59%***][KOG0111:98%****]
Eukaryota@jgi_Phypa1_1_37849[169][RRM1:100%*****][put-sr:5%**][GRSRBP:33%****][.hnRNP:18%***][.RBMY:15%***][KOG0108:23%***][.KOG0111:23%***][.KOG0149:18%***][.KOG0117:11%**][.KOG0116:9%**]
Euteleostomi@ENSGALP00000012472[36][RRM4:89%***][.RRM2:8%*][nucleolin:56%**][KOG0123:100%***]
Magnoliophyta@NP_181287[9][RRM1:100%**][oligoU:22%][KOG0148:56%*][.KOG0127:22%][.KOG0145:11%][.KOG0113:11%]
Eukaryota@XP_391240[27][RRM2:67%**][.RRM1:33%**][cpRNP:19%*][KOG0127:48%**][.KOG0108:22%*][.KOG0131:15%*][.KOG0149:7%][.KOG0145:7%]
Coelomata@AGAP006798-PA[81][RRM1:100%****][put-sr:99%****][KOG0122:26%***][.KOG0125:25%**][.KOG0147:14%**][.KOG0108:9%*]
Eukaryota@jgi_Physo1_1_108557[316][RRM2:91%*****][.RRM1:9%***][PABP:46%****][KOG0123:79%*****][.KOG0131:21%****]
Embryophyta@29727_m000492[13][RRM3:92%**][.RRM2:8%][oligoU:46%*][KOG0148:100%**]
Eukaryota@IMGA_AC144483_30_2[123][RRM2:83%****][.RRM1:17%***][TIATIAR:58%****][.oligoU:6%*][KOG0148:99%****]
Eukaryota@ENSMUSP00000030730[72][RRM2:85%****][.RRM1:15%**][oligoU:10%*][KOG0148:58%***][.KOG0123:25%**][.KOG0131:14%**]
Embryophyta@NP_001067623[8][RRM1:100%**][KOG0117:100%**]
Bilateria@ENSORLP00000004891[130][RRM1:100%****][RBMS:72%****][KOG0145:99%****]
Eukaryota@NP_001058102[93][RRM1:100%****][RBM:52%***][.30kRRM:13%**][KOG0149:96%****]
Magnoliophyta@NP_001042672[10][RRM1:100%**][oligoU:50%*][KOG4205:80%**][.KOG0149:20%]
Coelomata@SINFRUP00000146060[58][RRM1:100%****][TARDBP:72%***][KOG4205:98%****]
Endopterygota@CG16901-PC[19][RRM1:100%**][KOG4205:100%**]
Eukaryota@ENSMODP00000031317[289][RRM1:100%*****][hnRNP:28%****][.Musashi:13%***][.Dazap:9%***][KOG4205:99%*****]
Bilateria@ENSRNOP00000022054[326][RRM1:100%*****][hnRNP:54%*****][KOG4205:100%*****]
Ciona@ENSCINP00000012771[9][RRM1:100%**][put-sr:11%][KOG4205:100%**]
Eukaryota@AGAP006656-PA[121][RRM2:88%****][.RRM1:12%**][Musashi:36%***][.Dazap:21%***][.hnRNP:10%**][KOG4205:100%****]
Endopterygota@AAEL008257-PA[8][RRM2:100%**][KOG4205:100%**]
Deuterostomia@ENSMODP00000011218[78][RRM1:100%****][G3BP:82%****][KOG0116:100%****]
Viridiplantae@NP_851001[17][RRM2:100%**][put-sr:12%][KOG4205:94%**][.KOG1833:6%]
Euteleostomi@ENSEEUP00000005436[64][RRM1:95%****]
Coelomata@AAEL001684-PA[39][RRM1:100%***][KOG0125:21%**]
Endopterygota@XP_001121454[19][RRM2:100%**][KOG4205:100%**]
Mammalia@ENSETEP00000003776[19][RRM1:100%**][LA:95%**][KOG4213:100%**]
Euteleostomi@ENSDARP00000005968[129][RRM2:95%****][.RRM1:5%*][hnRNP:57%****][KOG4205:100%****]
Coelomata@CG6354-PB[373][RRM2:95%*****][hnRNP:53%*****][KOG4205:100%*****]
Ciona@ENSCINP00000008394[8][RRM2:100%**][KOG4205:100%**]
Embryophyta@NP_001062111[8][RRM1:100%**][put-sr:62%*][KOG4849:38%*][.KOG4246:12%][.KOG0113:12%][.KOG4676:12%]
Eukaryota@IMGA_AC183923_6_1[34][RRM3:74%***][.RRM1:15%*][.RRM2:12%*][put-sr:6%][KOG0110:100%***]
Euteleostomi@ENSSTOP00000002132[31][RRM1:100%***][SART3:68%***][KOG0128:100%***]
Coelomata@ENSDARP00000093407[32][RRM2:88%***][.RRM1:12%*][KOG0108:12%*][.KOG3001:6%][.KOG0123:6%][.KOG0126:6%]
Coelomata@XP_001182806[39][RRM1:100%***][KOG0108:13%*][.KOG0116:8%*][.KOG0921:5%]
Euteleostomi@ENSSARP00000000775[28][RRM1:100%***][eIF4B:54%**]
Eukaryota@ENSMLUP00000011758[47][RRM1:100%***][put-sr:91%***][UMH:64%***][.CAPER:15%*][KOG0147:100%***]
Eukaryota@ENSCSAVP00000003369[89][RRM1:100%****][put-sr:17%**][PABP:26%***][KOG4209:100%****]
Viridiplantae@jgi_Chlre3_99594[25][RRM1:100%***][KOG0123:8%]
Chordata@ENSETEP00000010530[36][RRM1:50%**][.RRM2:50%**][put-sr:100%***][SRrp:75%***][KOG4676:100%***]
Eukaryota@8925_m000027_AZM5_1178[67][RRM1:100%****][put-sr:84%****][SR:61%***][KOG4207:61%***][.KOG4368:24%**]
Embryophyta@30076_m004622[9][RRM1:100%**][FCAFPA:22%][KOG0144:100%**]
Deuterostomia@ENSDNOP00000008593[94][RRM1:100%****][P54nrb:28%***][.PSP1:21%**][.PSF:18%**][KOG0115:99%****]
Endopterygota@CG10328-PA[9][RRM1:100%**][P54nrb:33%*][KOG0115:100%**]
Euteleostomi@GSTENP00013801001[29][RRM1:100%***][LA:59%**][KOG1855:100%***]
Euteleostomi@ENSGACP00000016696[19][RRM3:79%**][.RRM4:11%][.RRM1:11%][RBM:58%**][KOG0127:100%**]
Eukaryota@ENSMODP00000034858[66][RRM1:100%****][KOG0121:100%****]
Eukaryota@jgi_Phatr2_8132[54][RRM1:100%***][KOG0114:100%***]
Embryophyta@jgi_Phypa1_1_217831[15][RRM3:93%**][.RRM1:7%][KOG0117:100%**]
Euteleostomi@ENSSTOP00000002923[18][RRM1:100%**][KOG4205:11%]
Eukaryota@NP_001053839[55][RRM6:42%***][.RRM5:35%**][.RRM4:11%*][.RRM3:9%*][KOG0110:100%****]
Embryophyta@30128_m008555[15][RRM1:100%**][KOG4660:100%**]
Euteleostomi@GSTENP00022906001[41][RRM3:83%***][.RRM2:10%*][.RRM1:7%*][nucleolin:54%***][KOG0123:93%***]
Euteleostomi@ENSMODP00000021210[32][RRM2:97%***][nucleolin:59%**][KOG0123:100%***]
Chordata@ENSOGAP00000005376[31][RRM2:90%***][.RRM3:6%][RBM:39%**][KOG0127:100%***]
Embryophyta@29742_m001371[15][RRM2:80%**][.RRM1:20%*][put-sr:87%**][SR:67%**][KOG0106:100%**]
Coelomata@ENSCINP00000003632[126][RRM2:70%****][.RRM1:30%***][hnRNP:37%***][.GRSRBP:15%**][KOG4211:100%****]
Euteleostomi@ENSOCUP00000014007[29][RRM2:97%***][SART3:69%**][KOG0128:100%***]
Coelomata@ENSMUSP00000057332[45][RRM1:100%***][put-sr:100%***][RNPS1:64%***][KOG4209:87%***]
Viridiplantae@jgi_Phypa1_1_105411[8][RRM1:100%**][put-sr:100%**][SR:25%][KOG0117:12%][.KOG0462:12%]
Chordata@ENSETEP00000001114[45][RRM1:100%***][put-sr:96%***][SRrp:82%***][KOG0111:29%**][.KOG0415:13%*]
Viridiplantae@NP_001046448[23][RRM1:100%***][put-sr:91%***][SR:35%**][KOG4207:13%*][.KOG0127:13%*][.KOG0110:9%]
Eukaryota@ENSGALP00000022397[157][RRM1:100%*****][put-sr:75%****][SR:59%****][KOG0107:66%****]
Euteleostomi@ENSOANP00000024755[113][RRM1:100%****][hnRNP:36%***][.RALYL:15%**]
Eukaryota@ENSOANP00000021053[127][RRM1:100%****][put-sr:91%****][SR:61%****][KOG0106:55%****][.KOG0105:37%***]
Embryophyta@NP_194280[13][RRM1:100%**][put-sr:77%**][SR:62%**][KOG0106:100%**]
Eukaryota@ENSTBEP00000007356[92][RRM1:100%****][put-sr:82%****][SR:65%****][KOG0105:100%****]
Eukaryota@ENSGACP00000013006[79][RRM2:96%****][snRNP:30%***][KOG4206:100%****]
Ascomycota@YDL224C[8][RRM1:88%*][.RRM2:12%][KOG3598:12%][.KOG1457:12%]
Bilateria@ENSLAFP00000012959[197][RRM3:93%*****][.RRM2:5%**][hnRNP:36%****][KOG0117:100%*****]
Endopterygota@CG8597-PE[8][RRM2:100%**][LARK:62%*][KOG0109:100%**]
Coelomata@ENSXETP00000008271[74][RRM1:100%****][LARK:61%***][KOG0109:97%****]
Euteleostomi@ENSDNOP00000012760[63][RRM2:94%****][.RRM1:6%*][LARK:65%***][.RBM:21%**][KOG0109:97%****]
Clupeocephala@ENSORLP00000002364[10][RRM2:100%**][KOG0109:100%**]
Clupeocephala@ENSGACP00000025151[11][RRM1:100%**][KOG0109:100%**]
Mammalia@ENSTBEP00000003150[16][RRM1:100%**][RBM:94%**][KOG0109:100%**]
Eukaryota@jgi_Ostta4_3181[66][RRM1:100%****][put-sr:47%***][cyclophilin:32%***][KOG0415:97%****]
Deuterostomia@XP_001178221[30][RRM1:100%***][put-sr:63%**][snRNP:70%***][KOG0113:100%***]
Coelomata@XP_974651[54][RRM2:83%***][.RRM1:17%**][put-sr:87%***][RBM:37%**][KOG0112:100%***]
Coelomata@ENSMMUP00000010529[37][RRM3:54%**][.RRM2:41%**][.RRM1:5%][put-sr:92%***][KOG0112:84%***][.KOG3598:8%*]
Eukaryota@GSTENP00007343001[69][RRM1:100%****][FCAFPA:10%*][KOG0533:99%****]
Coelomata@XP_782270[24][RRM1:100%***][Bruno:42%**][KOG0144:100%***]
Bilateria@ENSXETP00000031370[81][RRM1:100%****][Bruno:42%***][KOG0146:84%****][.KOG0144:16%**]
Bilateria@ENSGALP00000025475[210][RRM1:100%*****][hnRNP:33%****][KOG0117:100%*****]
Bilateria@AGAP009477-PA[250][RRM2:73%*****][.RRM1:27%****][Bruno:59%****][KOG0144:56%****][.KOG0146:44%****]
Embryophyta@jgi_Phypa1_1_115029[9][RRM2:100%**][KOG0144:100%**]
Embryophyta@29889_m003323[11][RRM2:100%**][FCAFPA:18%][KOG0144:100%**]
Eukaryota@NP_001063859[35][RRM1:100%***][ZCRB1:69%***][KOG0108:40%**][.KOG0122:9%*][.KOG0117:6%][.KOG0107:6%]
Eukaryota@jgi_Volca1_104604[49][RRM1:100%***][put-sr:78%***][KOG0151:100%***]
Coelomata@XP_975014[28][RRM1:100%***][RBM:86%***][KOG0153:100%***]
Eutheria@ENSETEP00000000464[10][RRM1:100%**][put-sr:100%**][KOG0132:100%**]
Euteleostomi@ENSOANP00000013028[22][RRM1:100%***]
Euteleostomi@ENSMODP00000018834[25][RRM1:100%***][put-sr:64%**][KOG0147:48%**][.KOG0132:12%*]
Diptera@AGAP003899-PA[15][RRM2:100%**][KOG0145:100%**]
Bilateria@CG3151-PE[218][RRM2:92%*****][.RRM1:7%**][ELAV:84%*****][KOG0145:100%*****]
Tetrapoda@ENSXETP00000004736[17][RRM2:59%**][.RRM1:41%*][PTBP:94%**][KOG1190:100%**]
Embryophyta@IMGA_AC141435_12_2[17][RRM2:76%**][.RRM1:24%*][KOG4660:100%**]
Coelomata@ENSORLP00000008206[18][RRM1:100%**][snRNP:83%**][KOG4206:100%**]
Diptera@AAEL011150-PA[15][RRM1:100%**][KOG0145:100%**]
Bilateria@ENSORLP00000021434[219][RRM1:100%*****][ELAV:79%*****][KOG0145:100%*****]
Euteleostomi@ENSXETP00000044031[49][RRM2:76%***][.RRM1:24%**][KOG0145:41%**][.KOG0123:14%*][.KOG0110:14%*]
Coelomata@ENSTBEP00000005385[105][RRM2:86%****][.RRM1:14%**][P54nrb:30%***][.PSP1:24%***][.PSF:21%***][KOG0115:100%****]
Gammaproteobacteria@YP_001083500[11][RRM1:100%**][PROK:100%**][KOG0145:27%*][.KOG0108:18%][.KOG0144:9%][.KOG0122:9%]
Euteleostomi@GSTENP00029551001[21][RRM1:100%***][put-sr:10%][KOG0110:100%***]
Ascomycota@XP_001386803[10][RRM4:90%**][.RRM2:10%][KOG0110:100%**]
Euteleostomi@ENSGALP00000013474[20][RRM5:85%**][.RRM4:5%][.RRM3:5%][.RRM2:5%][put-sr:10%][KOG0110:100%**]
Eukaryota@ENSXETP00000023927[236][RRM1:100%*****][PABP:55%****][KOG0123:100%*****]
Eukaryota@NP_001064759[59][RRM1:100%****][snRNP:8%*][KOG0131:100%****]
Deuterostomia@ENSXETP00000012868[47][RRM1:100%***][KOG4454:60%***][.KOG0131:40%**]
Eukaryota@jgi_Volca1_82970[75][RRM2:91%****][.RRM1:9%*][put-sr:80%****][snRNP:53%***][KOG0120:100%****]
Eukaryota@AAEL002461-PA[78][RRM1:100%****][put-sr:29%***][KOG0126:100%****]
Euteleostomi@ENSDARP00000069729[82][RRM1:100%****][KOG1995:77%****][.KOG0921:16%**][.KOG2044:5%*]
Amniota@ENSMODP00000004174[11][RRM4:55%*][.RRM3:36%*][.RRM2:9%][put-sr:100%**][KOG0112:100%**]
Eukaryota@YHR086W[51][RRM3:76%***][.RRM2:20%**][oligoU:10%*][KOG0148:90%***]
Eukaryota@ENSOANP00000006980[251][RRM3:67%*****][.RRM2:24%****][.RRM1:10%***][Bruno:50%****][KOG0144:55%****][.KOG0146:45%****]
Eukaryota@CG6937-PA[73][RRM1:100%****][put-sr:5%*][KOG4208:99%****]
Eukaryota@jgi_Physo1_1_143842[43][RRM1:100%***][put-sr:47%**][snRNP:14%*][KOG0113:100%***]
Embryophyta@29900_m001607[13][RRM2:100%**][oligoU:38%*][KOG4205:77%**][.KOG0149:23%*]
Eukaryota@ENSDARP00000064611[84][RRM1:100%****][KOG0108:99%****]
Eukaryota@jgi_Thaps3_18841[52][RRM1:100%***][put-sr:56%***][RBM:42%***][KOG0130:100%***]
Embryophyta@NP_188026[13][RRM1:100%**][oligoU:38%*][KOG0148:100%**]
Bilateria@ENSSARP00000011721[82][RRM1:100%****][TIATIAR:80%****][KOG0148:100%****]
Dikarya@XP_960425[12][RRM3:100%**][PABP:17%][KOG0123:100%**]
Eukaryota@ENSFCAP00000006163[84][RRM2:88%****][.RRM1:12%**][put-sr:86%****][UMH:39%***][.CAPER:8%*][KOG0147:100%****]
Bilateria@ENSCSAVP00000007991[62][RRM2:95%****][.RRM1:5%*][UMH:74%***][KOG0124:100%****]
Bilateria@Y47G6A_20a[64][RRM1:100%****][UMH:73%***][KOG0124:100%****]
Coelomata@CG4787-PA[102][RRM3:74%****][.RRM2:16%**][.RRM1:11%**][TIATIAR:75%****][KOG0148:100%****] part of 79 - TIA TIAR OligoU
67 - UMH
5 - PABP
76 - TIA TIAR OligoU
20 - RBM
part of 79 - TIA TIAR OligoU
Part of 36 - snRNP82
9 - Bruno78 - OligoU
61
6964 - snRNP
4746
49
3 - PABP
59
1
Part of 4 - p54rnb
10 - ELAV
43
Part of 11 - ELAV RBMS
14 - RBM13
57 - ZCRB18 - Bruno
FCA FPA
2 - hnRNP
7 - Bruno FCA FPA
Part of 30 - PDIP FCA FPA
5453 - RBM
55
Part of 36 - snRNP38 - Cyclophilin
50 -51- 52 - LARK
Part of 63 - hnRNP
41 - snRNP
16 - dual RRM SR proteins
86 - hnRNP/RALYL17 - single-RRM Zn-K SR proteins
18
22a - single RRM SR proteins (plants)23 - SRrp
26 - SR4527 - RNPS1
37 - SART380 - hnRNP
56 - green plant-specific RS group of SR proteins71 - RBM
4260
Part of 63 - hnRNP
4424
72 - RBM81 - La
Part of 33 - p54nrb
22b - single RRM SR proteins (animals)85 - SRrp
83 - PABP75 - CAPER UMH
87 - eIF-4B
73 - SART3Part of 32
35 - G3BP
RBM
30K-RRM
hnRNP
Musashi
Dazap
TARDBP
OligoU
84 - La
62
77 - TIA TIAR OligoU
4 - PABP PSP1 PSF p54rnb missing
19 - cyclophilin66 - PaBP
6 - PABP
29 - dual-RRM
SR proteins
Part of 30
- hnRNP
6570 - RBM
Part of 68 - FOXPart of 11 - ELAV RBMS
12 - ELAV
Part of 68
88 - prokaryotic RRMS
28
Fig. S12
132
52 60
94 59
96
57
97
58
63
55
93
100 69
98 53
70
50
74
57 98
93
92
98
99
73
71 91
70
52
71
55
96
70 92
71
54
75 58
84
81
80 85
72
64
X t i li @ENSXETP00000057107[2][RRM1 100%][ t 100%][SR 100%][KOG0106 100%][SR 40]Ciona intestinalis@ENSCINP00000014783[RRM1][put-sr][KOG0106]
Caenorhabditis elegans@W02B12_3a[3][RRM1:100%*][put-sr:33%][SR:100%*][KOG0106:100%*][CeSRp75/rsp-1]Caenorhabditis elegans@W02B12_2[RRM1][put-sr][SR][KOG0106][CeSRp40/rsp-2]
Xenopus tropicalis@ENSXETP00000031465[2][RRM1:100%][put-sr:100%][KOG0105:100%]Ciona savignyi@ENSCSAVP00000019399[RRM1][put-sr][KOG0106]
Ciona intestinalis@ENSCINP00000022868[RRM1][KOG0106]Ciona savignyi@ENSCSAVP00000004366[3][RRM1:100%*][put-sr:100%*][KOG0106:100%*]Ciona intestinalis@ENSCINP00000010131[3][RRM1:100%*][put-sr:100%*][KOG0106:100%*]
Ciona intestinalis@ENSCINP00000016525[RRM1][put-sr][KOG0106]Theria@ENSBTAP00000017699[12][RRM1:100%**][put-sr:100%**][SR:100%**][KOG0106:50%*][.KOG0105:50%*][SRp75]Myotis lucifugus@ENSMLUP00000013443[RRM1][put-sr][SR][KOG0105][SRp75]Tetraodon nigroviridis@GSTENP00010110001[RRM1][put-sr][KOG0598]Smegmamorpha@ENSGACP00000003112[3][RRM1:100%*][put-sr:100%*][KOG0106:100%*]
Danio rerio@ENSDARP00000025299[RRM1][put-sr][KOG0105]Danio rerio@ENSDARP00000094522[RRM1][put-sr]
Danio rerio@ENSDARP00000095990[2][RRM1:100%][put-sr:100%][SR:50%][KOG0105:100%][SRp55]Oryzias latipes@ENSORLP00000004399[RRM1][put-sr][KOG0105]Tetraodontidae@SINFRUP00000158023[2][RRM1:100%][put-sr:100%][KOG3766:50%][.KOG0105:50%]
Danio rerio@ENSDARP00000022089[RRM1][put-sr][KOG0105]Gasterosteus aculeatus@ENSGACP00000008092[3][RRM1:100%*][put-sr:100%*][KOG0105:100%*]
Xenopus tropicalis@ENSXETP00000054329[RRM1][put-sr][KOG0105]Monodelphis domestica@ENSMODP00000030967[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:50%][.KOG0105:50%][SRp55]Cavia porcellus@ENSCPOP00000010577[RRM1][put-sr][SR][KOG0106][SRp55]Eutheria@ENSDNOP00000006506[3][RRM1:100%*][put-sr:67%][SR:100%*][KOG0105:67%][.KOG0106:33%][SRp55]Echinops telfairi@ENSETEP00000005046[RRM1][put-sr][SR][KOG0105][SRp55]Murinae@ENSMUSP00000017065[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp55]
Bos taurus@ENSBTAP00000011240[RRM1][put-sr][SR][KOG0105][SRp55]Oryza sativa_japonica_cultivar-group@NP_001052061[RRM1][put-sr][SR][KOG0106][RSp29]
Arabidopsis thaliana@NP_182184[RRM1][put-sr][SR][KOG0106][RSp31a]Arabidopsis thaliana@NP_567120[RRM1][put-sr][SR][KOG0106][RSp31]
Ricinus communis@29742_m001371[RRM1][KOG0106]Physcomitrella patens@jgi_Phypa1_1_167387[RRM1][put-sr][KOG0106]Oryza sativa_japonica_cultivar-group@NP_001045729[RRM1][put-sr][SR][KOG0106][RSp33]
Zea mays@8514_m000507_c0216K08[RRM1][SR][KOG0106][RSp33]Zea mays@10633_m000022_AZM5_5503[RRM1][KOG0106]
Ricinus communis@30147_m014308[RRM1][put-sr][KOG0106]Medicago truncatula@IMGA_AC152177_25_1[RRM1][put-sr][KOG0106]
Arabidopsis thaliana@NP_194280[RRM1][put-sr][SR][KOG0106][RSp40/SRp35]Arabidopsis thaliana@NP_851174[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][RSp41]
Ostreococcus lucimarinus@jgi_Ost9901_3_8794[RRM1][KOG0105]Caenorhabditis elegans@Y111B2A_18_1[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0105:100%*][CeSF2/ASF/rsp-3]
Phytophthora sojae@jgi_Physo1_1_142377[RRM1][put-sr][KOG0105]Phytophthora ramorum@jgi_Phyra1_1_46108[RRM1][KOG0105]
Volvox carteri@jgi_Volca1_45192[RRM1][put-sr][KOG0105]Chlamydomonas reinhardtii@jgi_Chlre3_129159[RRM1][put-sr][KOG0105]
Phytophthora ramorum@jgi_Phyra1_1_84100[RRM1][KOG0105]Phytophthora sojae@jgi_Physo1_1_138982[RRM1][KOG0105]
Volvox carteri@jgi_Volca1_72532[RRM1][put-sr][KOG0105]Chlamydomonas reinhardtii@jgi_Chlre3_120469[RRM1][KOG0105]
Oryza sativa_japonica_cultivar-group@NP_001060608[RRM1][put-sr][SR][KOG0105][SRp33a]Arabidopsis thaliana@NP_190512[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp34a]Medicago truncatula@IMGA_CT868739_2_1[RRM1][put-sr][SR][KOG0105][SRp34a]Ricinus communis@29827_m002610[RRM1][put-sr][KOG0105]
Physcomitrella patens@jgi_Phypa1_1_140978[RRM1][put-sr][KOG0105]Physcomitrella patens@jgi_Phypa1_1_113630[RRM1][put-sr][KOG0105]Physcomitrella patens@jgi_Phypa1_1_205547[RRM1][put-sr][KOG0105]
Oryza sativa_japonica_cultivar-group@NP_001050082[RRM1][put-sr][SR][KOG0105][SRp32]Oryza sativa_japonica_cultivar-group@NP_001055323[RRM1][put-sr][SR][KOG0105][SRp33b]
Arabidopsis thaliana@NP_683288[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp30]Arabidopsis thaliana@NP_850933[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0105:100%*][SR1/SRp34]
Arabidopsis thaliana@NP_567235[2][RRM1:100%][put-sr:50%][SR:100%][KOG0105:100%][SRp34b]Medicago truncatula@IMGA_AC134522_46_2[2][RRM1:100%][put-sr:100%][KOG0105:100%]Medicago truncatula@IMGA_AC144541_27_2[RRM1][put-sr][KOG0105]
Ricinus communis@29986_m001610[RRM1][put-sr][SR][KOG0105][SRp33a]Medicago truncatula@IMGA_AC174141_23_1[RRM1][put-sr][KOG0105]
Ricinus communis@30128_m008837[RRM1][put-sr][KOG0105]Ricinus communis@30128_m008840[RRM1][put-sr][KOG0105]
Plasmodium falciparum_3D7@XP_001351730[RRM1][put-sr][KOG0105]Plasmodium falciparum_3D7@XP_001347501[RRM1][put-sr][KOG0105]
Theileria parva_strain_Muguga@XP_766386[RRM1][put-sr][KOG0105]Ciona savignyi@ENSCSAVP00000010348[2][RRM1:100%][put-sr:100%][KOG0105:100%]
Ciona intestinalis@ENSCINP00000015147[RRM1][put-sr][KOG0105]Danio rerio@ENSDARP00000091488[2][RRM1:100%][put-sr:100%][KOG0105:100%]
Takifugu rubripes@SINFRUP00000145791[RRM1][put-sr][SR][KOG0105][SRp30c]Gasterosteus aculeatus@ENSGACP00000022361[2][RRM1:100%][put-sr:100%][KOG0105:100%]
Xenopus tropicalis@ENSXETP00000026703[RRM1][put-sr][SR][KOG0105][SRp30c]Monodelphis domestica@ENSMODP00000003831[RRM1][put-sr][SR][KOG0105][SRp30c]
Mus musculus@ENSMUSP00000031513[RRM1][put-sr][SR][KOG0105][SRp30c]Bos taurus@ENSBTAP00000016997[RRM1][put-sr][SR][KOG0105][SRp30c]Tupaia belangeri@ENSTBEP00000007356[RRM1][put-sr][SR][KOG0105][SRp30c]
Myotis lucifugus@ENSMLUP00000009421[RRM1][put-sr][SR][KOG0105][SRp30c]Eutheria@ENSCAFP00000015146[7][RRM1:100%*][put-sr:100%*][SR:86%*][KOG0105:100%*][SRp30c]
Oryctolagus cuniculus@ENSOCUP00000009368[RRM1][KOG0105]Nasonia vitripennis@XP_001605411[RRM1][put-sr][KOG0105]Apis mellifera@XP_393525[RRM1][put-sr][KOG0105]Diptera@AAEL006473-PA[3][RRM1:100%*][put-sr:100%*][KOG0105:100%*]
Tribolium castaneum@XP_967263[RRM1][put-sr][KOG0105]Oryzias latipes@ENSORLP00000006698[RRM1][put-sr][SR][KOG0105][ASF/SF2]Gasterosteus aculeatus@ENSGACP00000027276[RRM1][put-sr][SR][KOG0105][ASF/SF2]
Takifugu rubripes@SINFRUP00000151768[RRM1][put-sr][SR][KOG0105][ASF/SF2]Danio rerio@ENSDARP00000074866[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]Gasterosteus aculeatus@ENSGACP00000014666[RRM1][SR][KOG0105][ASF/SF2]Oryzias latipes@ENSORLP00000005758[RRM1][put-sr][SR][KOG0105][ASF/SF2]Tetraodontidae@SINFRUP00000136750[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]
Otolemur garnettii@ENSOGAP00000012982[RRM1][SR][KOG0105][ASF/SF2]Tupaia belangeri@ENSTBEP00000013333[RRM1][SR][KOG0105][ASF/SF2]Tetrapoda@ENSBTAP00000019644[17][RRM1:100%**][put-sr:53%**][SR:100%**][KOG0105:100%**][ASF/SF2]
Macaca mulatta@ENSMMUP00000004343[RRM1][SR][KOG0105][ASF/SF2]Echinops telfairi@ENSETEP00000004344[RRM1][SR][KOG0105][ASF/SF2]
ASF-like
"plant"
SRp75
SRp55
RS "plant"
SRp30c
ASF/SF2
N5
N6
Fig. S13
133
95
92
56
56
99 81
95
100 79
58 77
72 53
88
94
93
61
90
72 72
75
67 69
100
84 59
55
100
99
60
62 66
63
69
98
87
95
70
72 67
97
65
77
87
50
Th l i i d @j i Th 3 32790[RRM1][KOG0122]Chlamydomonas reinhardtii@jgi_Chlre3_112621[RRM1][KOG0122]Ostreococcus lucimarinus@jgi_Ost9901_3_6420[RRM1][KOG0122]
Ostreococcus tauri@jgi_Ostta4_5527[RRM1][KOG0122]Physcomitrella patens@jgi_Phypa1_1_196691[RRM1][KOG0122]Physcomitrella patens@jgi_Phypa1_1_164814[RRM1][KOG0122]
Oryza sativa_japonica_cultivar-group@NP_001048346[RRM1][KOG0122]Oryza sativa_japonica_cultivar-group@NP_001048347[RRM1][KOG0122]
Ricinus communis@29973_m000409[RRM1][KOG0122]Medicago truncatula@IMGA_AC174277_12_1[2][RRM1:100%][KOG0122:100%]
Medicago truncatula@IMGA_AC144431_18_2[RRM1][KOG0122]Arabidopsis thaliana@NP_187747[RRM1][TIF3][KOG0122][TIF3]
Arabidopsis thaliana@NP_196219[RRM1][TIF3][KOG0122][TIF3]Ciona savignyi@ENSCSAVP00000018514[RRM1][put-sr]
Strongylocentrotus purpuratus@XP_001178467[2][RRM1:100%][put-sr:100%]Drosophila melanogaster@CG5655-PA[RRM1][put-sr][KOG0107]
Anopheles gambiae@AGAP009142-PA[RRM1][put-sr][KOG0921]Tribolium castaneum@XP_969323[RRM1][put-sr][KOG0107]
Nasonia vitripennis@XP_001605989[RRM1][put-sr][KOG0107]Apis mellifera@XP_396951[RRM1][put-sr][KOG0107]
Phytophthora@jgi_Phyra1_1_75301[2][RRM1:100%][put-sr:100%][KOG0105:100%]Strongylocentrotus purpuratus@XP_001178394[2][RRM1:100%][put-sr:100%][KOG0116:100%]
Caenorhabditis elegans@C33H5_12a_1[5][RRM1:100%*][put-sr:40%][SR:100%*][KOG0107:60%*][.KOG0116:40%][CeSRp20/rsp-6]Chlamydomonas reinhardtii@jgi_Chlre3_132362[RRM1][KOG0107]
Chlamydomonas reinhardtii@jgi_Chlre3_192053[RRM1][put-sr][KOG0107]Volvox carteri@jgi_Volca1_121301[RRM1][put-sr][KOG0107]
Physcomitrella patens@jgi_Phypa1_1_143810[2][RRM1:100%][KOG0107:100%]Oryza sativa_japonica_cultivar-group@NP_001048352[RRM1][put-sr][SR][RSZp21b]
Oryza sativa_japonica_cultivar-group@NP_001057018[RRM1][put-sr][SR][RSZp21a]Oryza sativa_japonica_cultivar-group@NP_001047400[RRM1][put-sr][SR][KOG0107][RSZp23]
Arabidopsis thaliana@NP_973901[2][RRM1:100%][SR:100%][SRZ21/RSZ21]Arabidopsis thaliana@NP_194886[2][RRM1:100%][put-sr:100%][SR:100%][KOG0107:100%][SRZ22/RSZ22]
Arabidopsis thaliana@NP_180035[RRM1][put-sr][SR][RSZ22a]Ricinus communis@28610_m000073[RRM1][SR][KOG0107][SRZ21/RSZ21]
Ricinus communis@29848_m004475[RRM1][put-sr][SR][SRZ22/RSZ22]Medicago truncatula@IMGA_CR936368_17_2[RRM1][put-sr][KOG0107]
Ciona intestinalis@ENSCINP00000026132[3][RRM1:100%*][put-sr:100%*][KOG0415:67%]Ciona savignyi@ENSCSAVP00000012556[4][RRM1:100%*][put-sr:100%*]
Tribolium castaneum@XP_968789[RRM1][put-sr][KOG4368]Apis mellifera@XP_001122800[RRM1][put-sr][KOG0107]
Anopheles gambiae@AGAP008303-PA[RRM1][put-sr]Drosophila melanogaster@CG10203-PA[RRM1][put-sr][SR][KOG0107][9G8]Ciona intestinalis@ENSCINP00000022204[2][RRM1:100%][put-sr:100%][KOG0107:100%]Ciona savignyi@ENSCSAVP00000004510[RRM1][put-sr]
Strongylocentrotus purpuratus@XP_788595[2][RRM1:100%][put-sr:100%]Strongylocentrotus purpuratus@XP_001180596[2][RRM1:100%][put-sr:100%]
Apis mellifera@XP_001123058[2][RRM1:100%][put-sr:50%][KOG0107:100%]Endopterygota@XP_001599712[6][RRM1:100%*][put-sr:17%][KOG0107:83%*][.KOG2490:17%]Culicidae@AAEL001356-PA[3][RRM1:100%*][put-sr:100%*][KOG0108:67%][.KOG0107:33%]Drosophila melanogaster@CG1987-PA[RRM1][put-sr][KOG0107]Drosophila melanogaster@CG17136-PD[4][RRM1:100%*][put-sr:50%][KOG0107:100%*]
Danio rerio@ENSDARP00000051184[2][RRM1:100%][put-sr:100%]Percomorpha@ENSGACP00000016280[4][RRM1:100%*][put-sr:100%*][KOG0107:50%][.KOG4368:25%]
Oryzias latipes@ENSORLP00000000921[3][RRM1:100%*][put-sr:100%*][KOG4368:33%][.KOG0107:33%]Danio rerio@ENSDARP00000070952[RRM1][SR][KOG0107][9G8]Xenopus tropicalis@ENSXETP00000054077[2][RRM1:100%][put-sr:100%][SR:100%][9G8]Mammalia@ENSBTAP00000033048[27][RRM1:100%***][put-sr:78%***][SR:93%***][KOG0107:81%***][9G8]Spermophilus tridecemlineatus@ENSSTOP00000003936[RRM1][put-sr]
Gallus gallus@ENSGALP00000022397[RRM1][put-sr][SR][9G8]Gallus gallus@ENSGALP00000038155[RRM1][put-sr][SR][9G8]
Rattus norvegicus@ENSRNOP00000058047[RRM1][put-sr]Rattus norvegicus@ENSRNOP00000011102[RRM1][put-sr][SR][KOG0107][9G8]
Gallus gallus@ENSGALP00000022386[RRM1][put-sr][SR][9G8]Monodelphis domestica@ENSMODP00000010787[RRM1][put-sr][SR][KOG0107][9G8]
Canis familiaris@ENSCAFP00000009434[RRM1][put-sr][KOG0107]Rattus norvegicus@ENSRNOP00000040587[RRM1][put-sr][SR][KOG0107][9G8]
Xenopus tropicalis@ENSXETP00000033870[RRM1][KOG0107]Xenopus tropicalis@ENSXETP00000018945[RRM1][KOG0107]
Strongylocentrotus purpuratus@XP_789661[2][RRM1:100%][put-sr:100%][KOG0116:100%]Strongylocentrotus purpuratus@XP_001178879[2][RRM1:100%][put-sr:100%][KOG0107:100%]
Danio rerio@ENSDARP00000076899[2][RRM1:100%][put-sr:50%][SR:100%][KOG0107:100%][SRp20]Gasterosteus aculeatus@ENSGACP00000001355[RRM1][put-sr][SR][KOG0107][SRp20]
Oryzias latipes@ENSORLP00000000358[RRM1][put-sr][SR][KOG0107][SRp20]Danio rerio@ENSDARP00000035207[2][RRM1:100%][put-sr:50%][SR:100%][KOG0107:100%][SRp20]
Takifugu rubripes@SINFRUP00000136850[RRM1][SR][KOG0107][SRp20]Tetraodon nigroviridis@GSTENP00027331001[RRM1][SR][KOG0107][SRp20]
Gasterosteus aculeatus@ENSGACP00000001909[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0107:100%*][SRp20]Oryzias latipes@ENSORLP00000024888[RRM1][put-sr][SR][KOG0107][SRp20]
Takifugu rubripes@SINFRUP00000147448[RRM1][put-sr][SR][KOG0107][SRp20]Mus musculus@ENSMUSP00000100538[RRM1][put-sr][SR][KOG0107][SRp20]Tetrapoda@ENSBTAP00000004154[28][RRM1:100%***][put-sr:68%**][SR:100%***][KOG0107:100%***][SRp20]Eutheria@ENSEEUP00000001001[3][RRM1:100%*][put-sr:100%*]
Arabidopsis thaliana@NP_190918[RRM1][put-sr][SR][KOG0107][RSZ32]Arabidopsis thaliana@NP_850280[RRM1][put-sr][SR][KOG0107][RSZ33]
Oryza sativa_japonica_cultivar-group@NP_001042066[RRM1][put-sr][SR][KOG0109][RSZ37a]Oryza sativa_japonica_cultivar-group@NP_001054731[RRM1][put-sr][SR][RSZ39]
Ricinus communis@29805_m001527[RRM1][put-sr][KOG0109]Oryza sativa_japonica_cultivar-group@NP_001054489[RRM1][put-sr][SR][KOG0109][RSZ36]
Oryza sativa_japonica_cultivar-group@NP_001049771[RRM1][put-sr][SR][KOG0109][RSZ37b]Nasonia vitripennis@XP_001603815[2][RRM1:100%][put-sr:100%][KOG0105:100%]
Tribolium castaneum@XP_969451[RRM1][put-sr][KOG0105]Apis mellifera@XP_391860[RRM1][put-sr][KOG0105]
Tribolium castaneum@XP_966697[RRM1][put-sr][KOG0106]Aedes aegypti@AAEL012621-PA[RRM1][put-sr][KOG0105]
Diptera@AGAP004592-PA[7][RRM1:100%*][put-sr:71%*][SR:86%*][KOG0105:57%*][.KOG0106:43%*]Aedes aegypti@AAEL000769-PA[RRM1][put-sr][KOG0106]
Caenorhabditis elegans@T28D9_2a[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*][CeSC35-2/rsp-5]Cryptococcus neoformans_var._neoformans_JEC21@XP_567562[RRM1][KOG0106]
Schizosaccharomyces pombe_972h-@NP_594570[RRM1][put-sr][KOG0106]Neurospora crassa_OR74A@XP_960334[RRM1][put-sr][KOG0105]
Strongylocentrotus purpuratus@XP_001180940[2][RRM1:100%][put-sr:100%][KOG0106:100%]Danio rerio@ENSDARP00000043311[RRM1][put-sr][KOG0106]
Xenopus tropicalis@ENSXETP00000038885[RRM1][put-sr][KOG0106]Gasterosteus aculeatus@ENSGACP00000015556[RRM1][put-sr][KOG0106]Tetraodon nigroviridis@GSTENP00035800001[RRM1][put-sr][KOG0106]
Takifugu rubripes@SINFRUP00000169885[RRM1][put-sr][KOG0106]Gallus gallus@ENSGALP00000015427[RRM1][put-sr][KOG0106]
Gallus gallus@ENSGALP00000037225[RRM1][KOG0106]Oryzias latipes@ENSORLP00000011623[3][RRM1:100%*][put-sr:67%][SR:33%][KOG0106:100%*]
Gasterosteus aculeatus@ENSGACP00000010395[2][RRM1:100%][put-sr:100%][SR:50%][KOG0106:100%][SRp40]Tetraodontidae@SINFRUP00000132279[2][RRM1:100%][put-sr:50%][SR:50%][KOG0106:100%]
Danio rerio@ENSDARP00000069997[3][RRM1:100%*][put-sr:67%][SR:33%][KOG0106:100%*][SRp40]Ornithorhynchus anatinus@ENSOANP00000021051[RRM1][put-sr][SR][KOG0105][SRp40]
Ornithorhynchus anatinus@ENSOANP00000021052[RRM1][put-sr][SR][KOG0106][SRp40]Ornithorhynchus anatinus@ENSOANP00000021053[RRM1][put-sr][SR][KOG0106][SRp40]Afrotheria@ENSETEP00000016575[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][SRp40]Amniota@ENSBTAP00000015408[24][RRM1:100%***][put-sr:96%***][SR:100%***][KOG0106:54%**][.KOG0105:46%**][SRp40]
Sorex araneus@ENSSARP00000000971[RRM1][put-sr][SR][KOG0105][SRp40]Catarrhini@ENSP00000342294[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*][SRp40]
Xenopus tropicalis@ENSXETP00000057107[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][SRp40]
SRp20
RS2Z "plant"
RSZ "plant"
9G8
SRp40
N3
N4
Fig. S13
134
57
57 50 84
67
96
59 69
83
52
79 52
100
82
99 50
94
100 99
57
100
93
58
83
99
95
98
91
56 72
57 94
77 98
90 96
60
59 81
86 77
54 94
89
100
65 62
G t t l t @ENSGACP00000002897[RRM1][ t ][KOG0415]Tetraodon nigroviridis@GSTENP00010468001[RRM1][SRrp][KOG4207][SRp38]
Takifugu rubripes@SINFRUP00000150947[RRM1][put-sr]Oryzias latipes@ENSORLP00000009635[RRM1][SRrp][KOG4207][SRp38]
Xenopus tropicalis@ENSXETP00000011851[RRM1][put-sr]Mus musculus@ENSMUSP00000103794[RRM1][put-sr][SRrp][KOG0111][SRrp35]Echinops telfairi@ENSETEP00000001114[RRM1][put-sr]Catarrhini@ENSP00000358479[3][RRM1:100%*][put-sr:100%*][SRrp:100%*][SRrp35]
Erinaceus europaeus@ENSEEUP00000010036[RRM1][put-sr][SRrp][SRrp35]Cavia porcellus@ENSCPOP00000009809[RRM1][put-sr][SRrp][SRrp35]
Monodelphis domestica@ENSMODP00000022797[RRM1][put-sr][SRrp][SRrp35]Canis familiaris@ENSCAFP00000019234[RRM1][put-sr][SRrp][SRp38]Eutheria@ENSBTAP00000010616[19][RRM1:100%**][put-sr:100%**][SRrp:100%**][KOG0111:58%**][.KOG0415:21%*][SRp38]
Canis familiaris@ENSCAFP00000004604[RRM1][put-sr][SRrp][SRp38]Eutheria@ENSEEUP00000013029[3][RRM1:100%*][put-sr:100%*][SRrp:100%*][SRp38]Monodelphis domestica@ENSMODP00000016281[RRM1][put-sr][SRrp][SRp38]Rattus norvegicus@ENSRNOP00000011154[2][RRM1:100%][put-sr:100%][SRrp:100%][SRp38]Gallus gallus@ENSGALP00000006566[RRM1][put-sr][SRrp][SRp38]
Drosophila melanogaster@CG5442-PB[RRM1][put-sr][SR][KOG4207][SC35]Aedes aegypti@AAEL010340-PB[2][RRM1:100%][put-sr:100%][KOG4207:100%]
Anopheles gambiae@AGAP009742-PA[RRM1][put-sr][KOG4207]Tribolium castaneum@XP_969931[RRM1][put-sr]Apis mellifera@XP_393352[RRM1][put-sr]
Caenorhabditis elegans@EEED8_7b[2][RRM1:100%][put-sr:50%][SR:100%][KOG4207:50%][CeSC35/rsp-4]Strongylocentrotus purpuratus@XP_785989[2][RRM1:100%][put-sr:100%][KOG4207:100%]Strongylocentrotus purpuratus@XP_001180179[4][RRM1:100%*][KOG4207:100%*]Ciona intestinalis@ENSCINP00000008678[RRM1][put-sr][KOG4207]
Ciona savignyi@ENSCSAVP00000015651[RRM1][put-sr][KOG4207]Oryzias latipes@ENSORLP00000023350[RRM1][put-sr][SR][KOG4368][SC35]
Takifugu rubripes@SINFRUP00000176738[RRM1][put-sr][SR][KOG4207][SC35]Percomorpha@ENSGACP00000004058[2][RRM1:100%][put-sr:100%][SR:100%][SC35]Clupeocephala@ENSDARP00000074623[3][RRM1:100%*][put-sr:100%*][SR:67%][KOG4207:100%*][SC35]
Oryzias latipes@ENSORLP00000001513[RRM1][put-sr][SR][KOG4207][SC35]Bos taurus@ENSBTAP00000012614[2][RRM1:100%][put-sr:100%][KOG4207:100%]
Rattus norvegicus@ENSRNOP00000045342[2][RRM1:100%][KOG4207:100%]Mus musculus@ENSMUSP00000078984[RRM1][KOG4207]
Danio rerio@ENSDARP00000015569[RRM1][put-sr][SR][KOG4207][SC35]Xenopus tropicalis@ENSXETP00000054042[RRM1][put-sr][SR][SC35]
Homo sapiens@ENSP00000381889[RRM1][put-sr][KOG4207]Macaca mulatta@ENSMMUP00000010035[RRM1][put-sr][SR][SRp46]
Mammalia@ENSBTAP00000024299[19][RRM1:100%**][put-sr:95%**][SR:100%**][KOG4368:74%**][.KOG4207:26%*][SC35]Dasypus novemcinctus@ENSDNOP00000000330[RRM1][put-sr][SR][KOG4368][SC35]
Erinaceus europaeus@ENSEEUP00000008808[RRM1][put-sr][SR][SC35]Homo sapiens@ENSP00000350877[RRM1][KOG4207]Macaca mulatta@ENSMMUP00000034012[RRM1][SR][KOG4207][SC35]Pan troglodytes@ENSPTRP00000032751[RRM1][KOG4207]
Ostreococcus lucimarinus@jgi_Ost9901_3_8174[RRM1][KOG4207]Tribolium castaneum@XP_970765[RRM2][KOG0127]
Ostreococcus lucimarinus@jgi_Ost9901_3_9858[RRM1][KOG0108]Ostreococcus tauri@jgi_Ostta4_7793[RRM1][KOG0108]
Cyanidioschyzon merolae@gnl_CMER_CML202C[RRM1][put-sr]Zea mays@8925_m000027_AZM5_1178[RRM1][KOG4207]
Oryza sativa_japonica_cultivar-group@NP_001062094[RRM1][put-sr][SR][KOG0415][SC35a]Zea mays@20810_m000015_AZM5_89637[2][RRM1:100%][put-sr:50%][SR:50%][KOG4207:100%][SC35a]
Oryza sativa_japonica_cultivar-group@NP_001050263[RRM1][put-sr][SR][KOG4207][SC35c]Physcomitrella patens@jgi_Phypa1_1_172957[RRM1][put-sr][KOG0415]
Physcomitrella patens@jgi_Phypa1_1_122960[RRM1][put-sr][KOG4207]Oryza sativa_japonica_cultivar-group@NP_001060322[RRM1][put-sr][SR][KOG4207][SC35b]
Medicago truncatula@IMGA_AC144459_24_2[2][RRM1:100%][put-sr:100%][KOG4207:100%]Ricinus communis@29581_m000256[RRM1][put-sr][KOG4207]
Arabidopsis thaliana@NP_201225[2][RRM1:100%][put-sr:100%][SR:100%][KOG4207:100%][SC35]Neurospora crassa_OR74A@XP_965346[RRM1][KOG0110]
Yarrowia lipolytica@XP_500351[RRM2][KOG0123]Theileria parva_strain_Muguga@XP_765374[RRM2]Methylococcus capsulatus_str._Bath@YP_113294[RRM1][PROK]
Nitrosococcus oceani_ATCC_19707@YP_344593[RRM1][PROK]Aureococcus anophagefferens@jgi_Auran1_9404[RRM1][KOG0122]
Aureococcus anophagefferens@jgi_Auran1_9375[RRM1][KOG0122]Aureococcus anophagefferens@jgi_Auran1_9018[RRM1]
Aureococcus anophagefferens@jgi_Auran1_17018[RRM1][KOG0111]Cryptosporidium parvum_Iowa_II@XP_626081[RRM1][KOG0122]
Chlamydomonas reinhardtii@jgi_Chlre3_184151[RRM1][KOG0921]Volvox carteri@jgi_Volca1_103546[RRM1][KOG0116]
Thalassiosira pseudonana@jgi_Thaps3_20266[RRM1][KOG4207]Phaeodactylum tricornutum@jgi_Phatr2_8270[RRM1][KOG4207]
Thalassiosira pseudonana@jgi_Thaps3_20223[RRM1][KOG0108]Phaeodactylum tricornutum@jgi_Phatr2_8269[RRM1][KOG0108]
Aureococcus anophagefferens@jgi_Auran1_17889[RRM1][KOG4207]Yarrowia lipolytica@XP_503515[RRM1][KOG0122]
Candida glabrata_CBS138@XP_446998[RRM1][KOG0122]Saccharomyces cerevisiae@YDR429C[RRM1][KOG0122]
Ashbya gossypii_ATCC_10895@NP_984285[RRM1][KOG0122]Pichia stipitis_CBS_6054@XP_001388004[RRM1][KOG0122]
Debaryomyces hansenii_CBS767@XP_458660[RRM1][KOG0122]Aedes aegypti@AAEL010807-PA[RRM1][put-sr][KOG1080]
Oryzias latipes@ENSORLP00000016244[RRM1][KOG1080]Tetraodon nigroviridis@GSTENP00000272001[RRM1]
Mus musculus@ENSMUSP00000098297[RRM1]Macaca mulatta@ENSMMUP00000016612[RRM1]Eutheria@ENSBTAP00000022553[3][RRM1:100%*][KOG1080:100%*]
Ustilago maydis_521@XP_760099[RRM1][KOG0122]Schizosaccharomyces pombe_972h-@NP_595727[RRM1][KOG0122]
Aspergillus fumigatus_Af293@XP_755320[RRM1][KOG0122]Neurospora crassa_OR74A@XP_962716[RRM1][KOG0122]
Gibberella zeae_PH-1@XP_385241[RRM1][KOG0122]Leishmania infantum_JPCM5@XP_001468615[RRM1]
Plasmodium falciparum_3D7@XP_001349368[RRM1][KOG0122]Theileria parva_strain_Muguga@XP_765841[RRM1][KOG0122]
Caenorhabditis elegans@F22B5_2[RRM1][KOG0122]Cyanidioschyzon merolae@gnl_CMER_CMH159C[RRM1][KOG0122]
Dictyostelium discoideum_AX4@XP_641693[RRM1][KOG0122]Gasterosteus aculeatus@ENSGACP00000018150[RRM1][KOG0122]Clupeocephala@ENSDARP00000027672[2][RRM1:100%][KOG0122:100%]Tetrapoda@ENSBTAP00000003545[10][RRM1:100%**][KOG0122:100%**]Takifugu rubripes@SINFRUP00000147763[RRM1][KOG0122]
Tetraodon nigroviridis@GSTENP00034383001[RRM1][KOG0122]Strongylocentrotus purpuratus@XP_791582[2][RRM1:100%][KOG0122:100%]Ciona intestinalis@ENSCINP00000000359[RRM1][KOG0122]
Tribolium castaneum@XP_971711[RRM1][KOG0122]Apis mellifera@XP_391934[RRM1][KOG0122]
Nasonia vitripennis@XP_001606020[RRM1][KOG0122]Nasonia vitripennis@XP_001606872[RRM1][KOG0122]
Drosophila melanogaster@CG8636-PA[RRM1][KOG0122]Aedes aegypti@AAEL006851-PA[2][RRM1:100%][KOG0122:100%]
Anopheles gambiae@AGAP007668-PA[RRM1][KOG0122]Phytophthora sojae@jgi_Physo1_1_108333[RRM1][KOG0122]
Phytophthora ramorum@jgi_Phyra1_1_79758[RRM1][KOG0122]Phaeodactylum tricornutum@jgi_Phatr2_16281[RRM1][KOG0122]
Aureococcus anophagefferens@jgi_Auran1_9314[2][RRM1:100%][KOG0585:50%][.KOG0122:50%]Thalassiosira pseudonana@jgi_Thaps3_32790[RRM1][KOG0122]
SC35 "plant"
SRrp
SC35
Fig. S13
135
0.27
95
76
98
97
96 97
97
97
75
61
60
56 54
75
57 72
57
93
98
77
98
89
86
88
94
84 83
67
59
98 59
78
93 79
57 96
55
Thalassiosira pseudonana@jgi_Thaps3_19374[RRM1][KOG0121]Phaeodactylum tricornutum@jgi_Phatr2_13520[RRM1][KOG0121]
Caenorhabditis elegans@F26A3_2[RRM1][KOG0121]Phytophthora ramorum@jgi_Phyra1_1_46906[RRM1][KOG0121]
Cyanidioschyzon merolae@gnl_CMER_CMQ282C[RRM1][KOG0121]Cryptosporidium parvum_Iowa_II@XP_627536[RRM1][KOG0121]
Encephalitozoon cuniculi_GB-M1@NP_597585[RRM1][KOG0121]Pichia stipitis_CBS_6054@XP_001387884[RRM1][KOG0121]
Debaryomyces hansenii_CBS767@XP_458582[RRM1][KOG0121]Kluyveromyces lactis@XP_451996[RRM1][KOG0121]Candida glabrata_CBS138@XP_445241[RRM1][KOG0121]
Ashbya gossypii_ATCC_10895@NP_985498[RRM1][KOG0121]Saccharomyces cerevisiae@YPL178W[RRM1][KOG0121]
Plasmodium falciparum_3D7@XP_001351463[RRM1][KOG0121]Leishmania infantum_JPCM5@XP_001466901[RRM1][KOG0121]
Trypanosoma brucei_TREU927@XP_845318[RRM1][KOG0121]Theileria parva_strain_Muguga@XP_766484[RRM1][KOG0121]
Chlamydomonas reinhardtii@jgi_Chlre3_169371[RRM1][KOG0121]Volvox carteri@jgi_Volca1_79141[RRM1][KOG0121]
Oryza sativa_japonica_cultivar-group@NP_001047412[RRM1][KOG0121]Arabidopsis thaliana@NP_199233[2][RRM1:100%][KOG0121:100%]
Ricinus communis@29983_m003140[RRM1][KOG0121]Ostreococcus lucimarinus@jgi_Ost9901_3_43898[RRM1][KOG0121]
Ostreococcus tauri@jgi_Ostta4_21085[RRM1][KOG0121]Drosophila melanogaster@CG12357-PA[RRM1][KOG0121]
Aedes aegypti@AAEL006135-PA[RRM1][KOG0121]Anopheles gambiae@AGAP002547-PA[RRM1][KOG0121]
Ciona savignyi@ENSCSAVP00000009906[RRM1][KOG0121]Ciona intestinalis@ENSCINP00000006257[2][RRM1:100%][KOG0121:100%]Nasonia vitripennis@XP_001600470[RRM1][KOG0121]
Nasonia vitripennis@XP_001608109[RRM1][KOG0121]Apis mellifera@XP_397316[RRM1][KOG0121]
Strongylocentrotus purpuratus@XP_001187788[2][RRM1:100%][KOG0121:100%]Tribolium castaneum@XP_975066[RRM1][KOG0121]
Dictyostelium discoideum_AX4@XP_637361[RRM1][KOG0121]Schizosaccharomyces pombe_972h-@NP_596414[RRM1][KOG0121]
Aspergillus fumigatus_Af293@XP_755191[RRM1][KOG0121]Gibberella zeae_PH-1@XP_385664[RRM1][KOG0121]
Eutheria@ENSBTAP00000011684[11][RRM1:100%**][KOG0121:100%**]Sorex araneus@ENSSARP00000012929[RRM1][KOG0121]
Cavia porcellus@ENSCPOP00000002703[RRM1][KOG0121]Loxodonta africana@ENSLAFP00000005354[RRM1][KOG0121]
Spermophilus tridecemlineatus@ENSSTOP00000001416[RRM1][KOG0121]Oryctolagus cuniculus@ENSOCUP00000012352[RRM1][KOG0121]Monodelphis domestica@ENSMODP00000029243[RRM1][KOG0121]
Monodelphis domestica@ENSMODP00000034858[2][RRM1:100%][KOG0121:100%]Monodelphis domestica@ENSMODP00000019849[RRM1][KOG0121]
Gallus gallus@ENSGALP00000011061[RRM1][KOG0121]Gallus gallus@ENSGALP00000009225[RRM1][KOG0121]Xenopus tropicalis@ENSXETP00000041997[RRM1][KOG0121]
Erinaceus europaeus@ENSEEUP00000004164[RRM1][KOG0121]Equus caballus@XP_001492661[RRM1][KOG0121]
Canis familiaris@ENSCAFP00000026571[RRM1][KOG0121]Oryzias latipes@ENSORLP00000014087[RRM1][KOG0121]Danio rerio@ENSDARP00000020688[RRM1][KOG0121]
Gasterosteus aculeatus@ENSGACP00000008263[RRM1][KOG0121]Tetraodon nigroviridis@GSTENP00011485001[RRM1][KOG0121]
Takifugu rubripes@SINFRUP00000128783[RRM1][KOG0121]Aureococcus anophagefferens@jgi_Auran1_17068[RRM1][KOG4207]
Phytophthora sojae@jgi_Physo1_1_136528[RRM1][put-sr]Phytophthora ramorum@jgi_Phyra1_1_75322[RRM1][KOG3208]
Cryptosporidium parvum_Iowa_II@XP_628282[RRM1][put-sr][KOG4207]Cryptosporidium parvum_Iowa_II@XP_627626[RRM1][put-sr][KOG0111]
Plasmodium falciparum_3D7@XP_001347950[RRM1][KOG4207]Plasmodium falciparum_3D7@XP_001351591[RRM1]
Chlamydomonas reinhardtii@jgi_Chlre3_116256[RRM1][put-sr]Volvox carteri@jgi_Volca1_121229[RRM1][put-sr][KOG0415]
Arabidopsis thaliana@NP_187966[RRM1][put-sr][SR][SCL30a]Arabidopsis thaliana@NP_001031195[2][RRM1:100%][put-sr:100%][SR:100%][KOG0110:100%][SR33/SCL33]Ricinus communis@30084_m000177[RRM1][put-sr]
Ricinus communis@27553_m000316[RRM1][put-sr]Medicago truncatula@IMGA_AC146760_9_2[RRM1][put-sr]
Oryza sativa_japonica_cultivar-group@NP_001060372[RRM1][put-sr][SR][SCL25]Oryza sativa_japonica_cultivar-group@NP_001050213[RRM1][put-sr][KOG4207]
Physcomitrella patens@jgi_Phypa1_1_141868[RRM1]Physcomitrella patens@jgi_Phypa1_1_108464[RRM1][put-sr]
Oryza sativa_japonica_cultivar-group@NP_001050168[RRM1][put-sr]Ricinus communis@29726_m003960[RRM1][put-sr]
Arabidopsis thaliana@NP_197382[RRM1][put-sr][SR][KOG0127][SCL28]Oryza sativa_japonica_cultivar-group@NP_001068546[RRM1][put-sr][KOG0127]
Oryza sativa_japonica_cultivar-group@NP_001046448[RRM1][put-sr][SR][SCL30a]Oryza sativa_japonica_cultivar-group@NP_001067091[RRM1][put-sr][SR][SCL30b]
Ricinus communis@27383_m000159[RRM1][put-sr][KOG0127]Medicago truncatula@IMGA_CR962128_15_2[RRM1][put-sr]
Arabidopsis thaliana@NP_567021[RRM1][put-sr][SR][KOG0122][SCL30]Phytophthora sojae@jgi_Physo1_1_138511[RRM1][put-sr]
Phaeodactylum tricornutum@jgi_Phatr2_12366[RRM1]Thalassiosira pseudonana@jgi_Thaps3_23196[RRM1][KOG4207]
Chlamydomonas reinhardtii@jgi_Chlre3_188086[RRM1][put-sr]Volvox carteri@jgi_Volca1_120666[RRM1][put-sr]
Volvox carteri@jgi_Volca1_73973[RRM1][put-sr][KOG4207]Chlamydomonas reinhardtii@jgi_Chlre3_113900[RRM1][KOG4207]
Ciona savignyi@ENSCSAVP00000008618[RRM1][put-sr][KOG0111]Gasterosteus aculeatus@ENSGACP00000018038[RRM1][put-sr]Danio rerio@ENSDARP00000091866[RRM1][put-sr]
Danio rerio@ENSDARP00000031512[RRM1][put-sr][KOG0415]Gasterosteus aculeatus@ENSGACP00000002897[RRM1][put-sr][KOG0415]
SCL
N2
Fig. S13
136
64 76
96
95
97
63
93
98 57
99 54
75
66
99
98
99
95
94
70 92
78
62
60
62
67
56
97
72 98
63
63
62
85
73 91
73 70
57
64
G t t l t @ENSGACP00000010395[2][RRM1 100%][ t 100%][SR 50%][KOG0106 100%][SR 40]Tetraodontidae@SINFRUP00000132279[2][RRM1:100%][put-sr:50%][SR:50%][KOG0106:100%]
Danio rerio@ENSDARP00000069997[3][RRM1:100%*][put-sr:67%][SR:33%][KOG0106:100%*][SRp40]Ciona intestinalis@ENSCINP00000014783[RRM1][put-sr][KOG0106]
Caenorhabditis elegans@W02B12_3a[3][RRM1:100%*][put-sr:33%][SR:100%*][KOG0106:100%*][CeSRp75/rsp-1]Caenorhabditis elegans@W02B12_2[RRM1][put-sr][SR][KOG0106][CeSRp40/rsp-2]
Theria@ENSBTAP00000017699[12][RRM1:100%**][put-sr:100%**][SR:100%**][KOG0106:50%*][.KOG0105:50%*][SRp75]Myotis lucifugus@ENSMLUP00000013443[RRM1][put-sr][SR][KOG0105][SRp75]
Xenopus tropicalis@ENSXETP00000031465[2][RRM1:100%][put-sr:100%][KOG0105:100%]Ciona savignyi@ENSCSAVP00000019399[RRM1][put-sr][KOG0106]
Ciona intestinalis@ENSCINP00000022868[RRM1][KOG0106]Ciona savignyi@ENSCSAVP00000004366[3][RRM1:100%*][put-sr:100%*][KOG0106:100%*]
Ciona intestinalis@ENSCINP00000016525[RRM1][put-sr][KOG0106]Ciona intestinalis@ENSCINP00000010131[3][RRM1:100%*][put-sr:100%*][KOG0106:100%*]
Tetraodon nigroviridis@GSTENP00010110001[RRM1][put-sr][KOG0598]Smegmamorpha@ENSGACP00000003112[3][RRM1:100%*][put-sr:100%*][KOG0106:100%*]
Danio rerio@ENSDARP00000025299[RRM1][put-sr][KOG0105]Danio rerio@ENSDARP00000094522[RRM1][put-sr]
Danio rerio@ENSDARP00000095990[2][RRM1:100%][put-sr:100%][SR:50%][KOG0105:100%][SRp55]Oryzias latipes@ENSORLP00000004399[RRM1][put-sr][KOG0105]Tetraodontidae@SINFRUP00000158023[2][RRM1:100%][put-sr:100%][KOG3766:50%][.KOG0105:50%]
Gasterosteus aculeatus@ENSGACP00000008092[3][RRM1:100%*][put-sr:100%*][KOG0105:100%*]Danio rerio@ENSDARP00000022089[RRM1][put-sr][KOG0105]
Xenopus tropicalis@ENSXETP00000054329[RRM1][put-sr][KOG0105]Monodelphis domestica@ENSMODP00000030967[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:50%][.KOG0105:50%][SRp55]Murinae@ENSMUSP00000017065[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp55]
Bos taurus@ENSBTAP00000011240[RRM1][put-sr][SR][KOG0105][SRp55]Eutheria@ENSDNOP00000006506[3][RRM1:100%*][put-sr:67%][SR:100%*][KOG0105:67%][.KOG0106:33%][SRp55]
Echinops telfairi@ENSETEP00000005046[RRM1][put-sr][SR][KOG0105][SRp55]Cavia porcellus@ENSCPOP00000010577[RRM1][put-sr][SR][KOG0106][SRp55]
Oryza sativa_japonica_cultivar-group@NP_001052061[RRM1][put-sr][SR][KOG0106][RSp29]Ricinus communis@29742_m001371[RRM1][KOG0106]
Arabidopsis thaliana@NP_182184[RRM1][put-sr][SR][KOG0106][RSp31a]Arabidopsis thaliana@NP_567120[RRM1][put-sr][SR][KOG0106][RSp31]
Physcomitrella patens@jgi_Phypa1_1_167387[RRM1][put-sr][KOG0106]Oryza sativa_japonica_cultivar-group@NP_001045729[RRM1][put-sr][SR][KOG0106][RSp33]
Zea mays@10633_m000022_AZM5_5503[RRM1][KOG0106]Zea mays@8514_m000507_c0216K08[RRM1][SR][KOG0106][RSp33]
Ricinus communis@30147_m014308[RRM1][put-sr][KOG0106]Medicago truncatula@IMGA_AC152177_25_1[RRM1][put-sr][KOG0106]
Arabidopsis thaliana@NP_851174[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][RSp41]Arabidopsis thaliana@NP_194280[RRM1][put-sr][SR][KOG0106][RSp40/SRp35]
Phytophthora ramorum@jgi_Phyra1_1_84100[RRM1][KOG0105]Phytophthora sojae@jgi_Physo1_1_138982[RRM1][KOG0105]
Volvox carteri@jgi_Volca1_72532[RRM1][put-sr][KOG0105]Chlamydomonas reinhardtii@jgi_Chlre3_120469[RRM1][KOG0105]
Caenorhabditis elegans@Y111B2A_18_1[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0105:100%*][CeSF2/ASF/rsp-3]Volvox carteri@jgi_Volca1_45192[RRM1][put-sr][KOG0105]
Chlamydomonas reinhardtii@jgi_Chlre3_129159[RRM1][put-sr][KOG0105]Phytophthora ramorum@jgi_Phyra1_1_46108[RRM1][KOG0105]
Phytophthora sojae@jgi_Physo1_1_142377[RRM1][put-sr][KOG0105]Oryza sativa_japonica_cultivar-group@NP_001060608[RRM1][put-sr][SR][KOG0105][SRp33a]
Physcomitrella patens@jgi_Phypa1_1_140978[RRM1][put-sr][KOG0105]Physcomitrella patens@jgi_Phypa1_1_113630[RRM1][put-sr][KOG0105]
Physcomitrella patens@jgi_Phypa1_1_205547[RRM1][put-sr][KOG0105]Arabidopsis thaliana@NP_190512[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp34a]Ricinus communis@29827_m002610[RRM1][put-sr][KOG0105]Medicago truncatula@IMGA_CT868739_2_1[RRM1][put-sr][SR][KOG0105][SRp34a]
Ricinus communis@29986_m001610[RRM1][put-sr][SR][KOG0105][SRp33a]Ricinus communis@30128_m008840[RRM1][put-sr][KOG0105]
Ricinus communis@30128_m008837[RRM1][put-sr][KOG0105]Medicago truncatula@IMGA_AC174141_23_1[RRM1][put-sr][KOG0105]
Medicago truncatula@IMGA_AC134522_46_2[2][RRM1:100%][put-sr:100%][KOG0105:100%]Medicago truncatula@IMGA_AC144541_27_2[RRM1][put-sr][KOG0105]
Arabidopsis thaliana@NP_850933[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0105:100%*][SR1/SRp34]Arabidopsis thaliana@NP_567235[2][RRM1:100%][put-sr:50%][SR:100%][KOG0105:100%][SRp34b]Arabidopsis thaliana@NP_683288[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp30]
Oryza sativa_japonica_cultivar-group@NP_001055323[RRM1][put-sr][SR][KOG0105][SRp33b]Oryza sativa_japonica_cultivar-group@NP_001050082[RRM1][put-sr][SR][KOG0105][SRp32]
Theileria parva_strain_Muguga@XP_766386[RRM1][put-sr][KOG0105]Plasmodium falciparum_3D7@XP_001347501[RRM1][put-sr][KOG0105]
Ciona savignyi@ENSCSAVP00000010348[2][RRM1:100%][put-sr:100%][KOG0105:100%]Ciona intestinalis@ENSCINP00000015147[RRM1][put-sr][KOG0105]
Danio rerio@ENSDARP00000091488[2][RRM1:100%][put-sr:100%][KOG0105:100%]Takifugu rubripes@SINFRUP00000145791[RRM1][put-sr][SR][KOG0105][SRp30c]
Gasterosteus aculeatus@ENSGACP00000022361[2][RRM1:100%][put-sr:100%][KOG0105:100%]Xenopus tropicalis@ENSXETP00000026703[RRM1][put-sr][SR][KOG0105][SRp30c]
Myotis lucifugus@ENSMLUP00000009421[RRM1][put-sr][SR][KOG0105][SRp30c]Eutheria@ENSCAFP00000015146[7][RRM1:100%*][put-sr:100%*][SR:86%*][KOG0105:100%*][SRp30c]
Tupaia belangeri@ENSTBEP00000007356[RRM1][put-sr][SR][KOG0105][SRp30c]Monodelphis domestica@ENSMODP00000003831[RRM1][put-sr][SR][KOG0105][SRp30c]
Mus musculus@ENSMUSP00000031513[RRM1][put-sr][SR][KOG0105][SRp30c]Bos taurus@ENSBTAP00000016997[RRM1][put-sr][SR][KOG0105][SRp30c]Oryctolagus cuniculus@ENSOCUP00000009368[RRM1][KOG0105]
Diptera@AAEL006473-PA[3][RRM1:100%*][put-sr:100%*][KOG0105:100%*]Tribolium castaneum@XP_967263[RRM1][put-sr][KOG0105]Nasonia vitripennis@XP_001605411[RRM1][put-sr][KOG0105]
Apis mellifera@XP_393525[RRM1][put-sr][KOG0105]Oryzias latipes@ENSORLP00000006698[RRM1][put-sr][SR][KOG0105][ASF/SF2]
Takifugu rubripes@SINFRUP00000151768[RRM1][put-sr][SR][KOG0105][ASF/SF2]Gasterosteus aculeatus@ENSGACP00000027276[RRM1][put-sr][SR][KOG0105][ASF/SF2]
Danio rerio@ENSDARP00000074866[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]Gasterosteus aculeatus@ENSGACP00000014666[RRM1][SR][KOG0105][ASF/SF2]Tetraodontidae@SINFRUP00000136750[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]Oryzias latipes@ENSORLP00000005758[RRM1][put-sr][SR][KOG0105][ASF/SF2]
Macaca mulatta@ENSMMUP00000004343[RRM1][SR][KOG0105][ASF/SF2]Echinops telfairi@ENSETEP00000004344[RRM1][SR][KOG0105][ASF/SF2]
Tetrapoda@ENSBTAP00000019644[17][RRM1:100%**][put-sr:53%**][SR:100%**][KOG0105:100%**][ASF/SF2]Tupaia belangeri@ENSTBEP00000013333[RRM1][SR][KOG0105][ASF/SF2]
Otolemur garnettii@ENSOGAP00000012982[RRM1][SR][KOG0105][ASF/SF2]
SRp75
ASF/SF2
SRp30c
ASF-like "plant"
RS "plant"
SRp55
N5
N6
Fig. S14
137
93
85 78
59 97
93
99 81
86 87
95
92
99 77
95
100
98
97
72
99
60 67
64
87
70 82
55 85
79
83
100 60
60
79
98
99
98
54
81
79 60
97
66
93
55
Ci i t ti li @ENSCINP00000000359[RRM1][KOG0122]Tetrapoda@ENSBTAP00000003545[10][RRM1:100%**][KOG0122:100%**]Clupeocephala@ENSDARP00000027672[2][RRM1:100%][KOG0122:100%]
Gasterosteus aculeatus@ENSGACP00000018150[RRM1][KOG0122]Tetraodon nigroviridis@GSTENP00034383001[RRM1][KOG0122]Takifugu rubripes@SINFRUP00000147763[RRM1][KOG0122]
Tribolium castaneum@XP_971711[RRM1][KOG0122]Apis mellifera@XP_391934[RRM1][KOG0122]
Nasonia vitripennis@XP_001606872[RRM1][KOG0122]Nasonia vitripennis@XP_001606020[RRM1][KOG0122]
Drosophila melanogaster@CG8636-PA[RRM1][KOG0122]Anopheles gambiae@AGAP007668-PA[RRM1][KOG0122]
Aedes aegypti@AAEL006851-PA[2][RRM1:100%][KOG0122:100%]Plasmodium falciparum_3D7@XP_001351730[RRM1][put-sr][KOG0105]
Ostreococcus lucimarinus@jgi_Ost9901_3_8794[RRM1][KOG0105]Phytophthora@jgi_Phyra1_1_75301[2][RRM1:100%][put-sr:100%][KOG0105:100%]
Caenorhabditis elegans@C33H5_12a_1[5][RRM1:100%*][put-sr:40%][SR:100%*][KOG0107:60%*][.KOG0116:40%][CeSRp20/rsp-6]Chlamydomonas reinhardtii@jgi_Chlre3_132362[RRM1][KOG0107]
Volvox carteri@jgi_Volca1_121301[RRM1][put-sr][KOG0107]Chlamydomonas reinhardtii@jgi_Chlre3_192053[RRM1][put-sr][KOG0107]
Physcomitrella patens@jgi_Phypa1_1_143810[2][RRM1:100%][KOG0107:100%]Oryza sativa_japonica_cultivar-group@NP_001048352[RRM1][put-sr][SR][RSZp21b]
Oryza sativa_japonica_cultivar-group@NP_001047400[RRM1][put-sr][SR][KOG0107][RSZp23]Oryza sativa_japonica_cultivar-group@NP_001057018[RRM1][put-sr][SR][RSZp21a]
Ricinus communis@28610_m000073[RRM1][SR][KOG0107][SRZ21/RSZ21]Medicago truncatula@IMGA_CR936368_17_2[RRM1][put-sr][KOG0107]
Ricinus communis@29848_m004475[RRM1][put-sr][SR][SRZ22/RSZ22]Arabidopsis thaliana@NP_180035[RRM1][put-sr][SR][RSZ22a]
Arabidopsis thaliana@NP_973901[2][RRM1:100%][SR:100%][SRZ21/RSZ21]Arabidopsis thaliana@NP_194886[2][RRM1:100%][put-sr:100%][SR:100%][KOG0107:100%][SRZ22/RSZ22]
Ciona savignyi@ENSCSAVP00000018514[RRM1][put-sr]Strongylocentrotus purpuratus@XP_001178467[2][RRM1:100%][put-sr:100%]
Drosophila melanogaster@CG5655-PA[RRM1][put-sr][KOG0107]Anopheles gambiae@AGAP009142-PA[RRM1][put-sr][KOG0921]
Tribolium castaneum@XP_969323[RRM1][put-sr][KOG0107]Nasonia vitripennis@XP_001605989[RRM1][put-sr][KOG0107]
Apis mellifera@XP_396951[RRM1][put-sr][KOG0107]Strongylocentrotus purpuratus@XP_001178394[2][RRM1:100%][put-sr:100%][KOG0116:100%]Ciona savignyi@ENSCSAVP00000012556[4][RRM1:100%*][put-sr:100%*]
Ciona intestinalis@ENSCINP00000026132[3][RRM1:100%*][put-sr:100%*][KOG0415:67%]Strongylocentrotus purpuratus@XP_789661[2][RRM1:100%][put-sr:100%][KOG0116:100%]Strongylocentrotus purpuratus@XP_001178879[2][RRM1:100%][put-sr:100%][KOG0107:100%]
Strongylocentrotus purpuratus@XP_001180596[2][RRM1:100%][put-sr:100%]Ciona savignyi@ENSCSAVP00000004510[RRM1][put-sr]Ciona intestinalis@ENSCINP00000022204[2][RRM1:100%][put-sr:100%][KOG0107:100%]
Drosophila melanogaster@CG10203-PA[RRM1][put-sr][SR][KOG0107][9G8]Anopheles gambiae@AGAP008303-PA[RRM1][put-sr]Tribolium castaneum@XP_968789[RRM1][put-sr][KOG4368]
Apis mellifera@XP_001122800[RRM1][put-sr][KOG0107]Xenopus tropicalis@ENSXETP00000033870[RRM1][KOG0107]
Xenopus tropicalis@ENSXETP00000018945[RRM1][KOG0107]Eutheria@ENSEEUP00000001001[3][RRM1:100%*][put-sr:100%*]
Gasterosteus aculeatus@ENSGACP00000001909[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0107:100%*][SRp20]Takifugu rubripes@SINFRUP00000147448[RRM1][put-sr][SR][KOG0107][SRp20]
Oryzias latipes@ENSORLP00000024888[RRM1][put-sr][SR][KOG0107][SRp20]Tetrapoda@ENSBTAP00000004154[28][RRM1:100%***][put-sr:68%**][SR:100%***][KOG0107:100%***][SRp20]
Mus musculus@ENSMUSP00000100538[RRM1][put-sr][SR][KOG0107][SRp20]Danio rerio@ENSDARP00000035207[2][RRM1:100%][put-sr:50%][SR:100%][KOG0107:100%][SRp20]
Oryzias latipes@ENSORLP00000000358[RRM1][put-sr][SR][KOG0107][SRp20]Tetraodon nigroviridis@GSTENP00027331001[RRM1][SR][KOG0107][SRp20]
Takifugu rubripes@SINFRUP00000136850[RRM1][SR][KOG0107][SRp20]Gasterosteus aculeatus@ENSGACP00000001355[RRM1][put-sr][SR][KOG0107][SRp20]Danio rerio@ENSDARP00000076899[2][RRM1:100%][put-sr:50%][SR:100%][KOG0107:100%][SRp20]
Strongylocentrotus purpuratus@XP_788595[2][RRM1:100%][put-sr:100%]Apis mellifera@XP_001123058[2][RRM1:100%][put-sr:50%][KOG0107:100%]Endopterygota@XP_001599712[6][RRM1:100%*][put-sr:17%][KOG0107:83%*][.KOG2490:17%]
Culicidae@AAEL001356-PA[3][RRM1:100%*][put-sr:100%*][KOG0108:67%][.KOG0107:33%]Drosophila melanogaster@CG17136-PD[4][RRM1:100%*][put-sr:50%][KOG0107:100%*]
Drosophila melanogaster@CG1987-PA[RRM1][put-sr][KOG0107]Percomorpha@ENSGACP00000016280[4][RRM1:100%*][put-sr:100%*][KOG0107:50%][.KOG4368:25%]
Oryzias latipes@ENSORLP00000000921[3][RRM1:100%*][put-sr:100%*][KOG4368:33%][.KOG0107:33%]Danio rerio@ENSDARP00000051184[2][RRM1:100%][put-sr:100%]
Gallus gallus@ENSGALP00000022386[RRM1][put-sr][SR][9G8]Spermophilus tridecemlineatus@ENSSTOP00000003936[RRM1][put-sr]
Monodelphis domestica@ENSMODP00000010787[RRM1][put-sr][SR][KOG0107][9G8]Rattus norvegicus@ENSRNOP00000040587[RRM1][put-sr][SR][KOG0107][9G8]
Canis familiaris@ENSCAFP00000009434[RRM1][put-sr][KOG0107]Xenopus tropicalis@ENSXETP00000054077[2][RRM1:100%][put-sr:100%][SR:100%][9G8]Mammalia@ENSBTAP00000033048[27][RRM1:100%***][put-sr:78%***][SR:93%***][KOG0107:81%***][9G8]
Danio rerio@ENSDARP00000070952[RRM1][SR][KOG0107][9G8]Rattus norvegicus@ENSRNOP00000058047[RRM1][put-sr]
Rattus norvegicus@ENSRNOP00000011102[RRM1][put-sr][SR][KOG0107][9G8]Gallus gallus@ENSGALP00000022397[RRM1][put-sr][SR][9G8]Gallus gallus@ENSGALP00000038155[RRM1][put-sr][SR][9G8]
Arabidopsis thaliana@NP_850280[RRM1][put-sr][SR][KOG0107][RSZ33]Arabidopsis thaliana@NP_190918[RRM1][put-sr][SR][KOG0107][RSZ32]
Oryza sativa_japonica_cultivar-group@NP_001054731[RRM1][put-sr][SR][RSZ39]Oryza sativa_japonica_cultivar-group@NP_001042066[RRM1][put-sr][SR][KOG0109][RSZ37a]
Ricinus communis@29805_m001527[RRM1][put-sr][KOG0109]Oryza sativa_japonica_cultivar-group@NP_001049771[RRM1][put-sr][SR][KOG0109][RSZ37b]
Oryza sativa_japonica_cultivar-group@NP_001054489[RRM1][put-sr][SR][KOG0109][RSZ36]Caenorhabditis elegans@T28D9_2a[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*][CeSC35-2/rsp-5]
Tribolium castaneum@XP_969451[RRM1][put-sr][KOG0105]Nasonia vitripennis@XP_001603815[2][RRM1:100%][put-sr:100%][KOG0105:100%]
Tribolium castaneum@XP_966697[RRM1][put-sr][KOG0106]Apis mellifera@XP_391860[RRM1][put-sr][KOG0105]
Aedes aegypti@AAEL000769-PA[RRM1][put-sr][KOG0106]Diptera@AGAP004592-PA[7][RRM1:100%*][put-sr:71%*][SR:86%*][KOG0105:57%*][.KOG0106:43%*]
Aedes aegypti@AAEL012621-PA[RRM1][put-sr][KOG0105]Cryptococcus neoformans_var._neoformans_JEC21@XP_567562[RRM1][KOG0106]
Schizosaccharomyces pombe_972h-@NP_594570[RRM1][put-sr][KOG0106]Neurospora crassa_OR74A@XP_960334[RRM1][put-sr][KOG0105]
Strongylocentrotus purpuratus@XP_001180940[2][RRM1:100%][put-sr:100%][KOG0106:100%]Gallus gallus@ENSGALP00000037225[RRM1][KOG0106]
Gallus gallus@ENSGALP00000015427[RRM1][put-sr][KOG0106]Oryzias latipes@ENSORLP00000011623[3][RRM1:100%*][put-sr:67%][SR:33%][KOG0106:100%*]
Xenopus tropicalis@ENSXETP00000038885[RRM1][put-sr][KOG0106]Gasterosteus aculeatus@ENSGACP00000015556[RRM1][put-sr][KOG0106]
Danio rerio@ENSDARP00000043311[RRM1][put-sr][KOG0106]Tetraodon nigroviridis@GSTENP00035800001[RRM1][put-sr][KOG0106]
Takifugu rubripes@SINFRUP00000169885[RRM1][put-sr][KOG0106]Sorex araneus@ENSSARP00000000971[RRM1][put-sr][SR][KOG0105][SRp40]Catarrhini@ENSP00000342294[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*][SRp40]
Xenopus tropicalis@ENSXETP00000057107[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][SRp40]Amniota@ENSBTAP00000015408[24][RRM1:100%***][put-sr:96%***][SR:100%***][KOG0106:54%**][.KOG0105:46%**][SRp40]Afrotheria@ENSETEP00000016575[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][SRp40]
Ornithorhynchus anatinus@ENSOANP00000021053[RRM1][put-sr][SR][KOG0106][SRp40]Ornithorhynchus anatinus@ENSOANP00000021052[RRM1][put-sr][SR][KOG0106][SRp40]
Ornithorhynchus anatinus@ENSOANP00000021051[RRM1][put-sr][SR][KOG0105][SRp40]Gasterosteus aculeatus@ENSGACP00000010395[2][RRM1:100%][put-sr:100%][SR:50%][KOG0106:100%][SRp40]
RS2Z "plant"
SRp40
RSZ "plant"
SRp20
9G8
N3
N4
Fig. S14
138
54 76
74
90
76
99
100 57
99
100
82
71 58
99
88 92
94
84
92
56 85
77 99
100
63
95
57 54
94
99
98
89
62
100
92 94
58
81
69 91
85
97
98
74 67
98
59
71
Ci i i@ENSCSAVP00000008618[RRM1][ t ][KOG0111]Gasterosteus aculeatus@ENSGACP00000018038[RRM1][put-sr]
Danio rerio@ENSDARP00000031512[RRM1][put-sr][KOG0415]Danio rerio@ENSDARP00000091866[RRM1][put-sr]Gasterosteus aculeatus@ENSGACP00000002897[RRM1][put-sr][KOG0415]
Tetraodon nigroviridis@GSTENP00010468001[RRM1][SRrp][KOG4207][SRp38]Takifugu rubripes@SINFRUP00000150947[RRM1][put-sr]
Oryzias latipes@ENSORLP00000009635[RRM1][SRrp][KOG4207][SRp38]Xenopus tropicalis@ENSXETP00000011851[RRM1][put-sr]
Mus musculus@ENSMUSP00000103794[RRM1][put-sr][SRrp][KOG0111][SRrp35]Echinops telfairi@ENSETEP00000001114[RRM1][put-sr]
Catarrhini@ENSP00000358479[3][RRM1:100%*][put-sr:100%*][SRrp:100%*][SRrp35]Erinaceus europaeus@ENSEEUP00000010036[RRM1][put-sr][SRrp][SRrp35]
Monodelphis domestica@ENSMODP00000022797[RRM1][put-sr][SRrp][SRrp35]Cavia porcellus@ENSCPOP00000009809[RRM1][put-sr][SRrp][SRrp35]
Canis familiaris@ENSCAFP00000019234[RRM1][put-sr][SRrp][SRp38]Eutheria@ENSBTAP00000010616[19][RRM1:100%**][put-sr:100%**][SRrp:100%**][KOG0111:58%**][.KOG0415:21%*][SRp38]
Canis familiaris@ENSCAFP00000004604[RRM1][put-sr][SRrp][SRp38]Eutheria@ENSEEUP00000013029[3][RRM1:100%*][put-sr:100%*][SRrp:100%*][SRp38]
Monodelphis domestica@ENSMODP00000016281[RRM1][put-sr][SRrp][SRp38]Rattus norvegicus@ENSRNOP00000011154[2][RRM1:100%][put-sr:100%][SRrp:100%][SRp38]Gallus gallus@ENSGALP00000006566[RRM1][put-sr][SRrp][SRp38]
Phytophthora sojae@jgi_Physo1_1_138511[RRM1][put-sr]Thalassiosira pseudonana@jgi_Thaps3_23196[RRM1][KOG4207]
Phaeodactylum tricornutum@jgi_Phatr2_12366[RRM1]Phytophthora sojae@jgi_Physo1_1_136528[RRM1][put-sr]
Phytophthora ramorum@jgi_Phyra1_1_75322[RRM1][KOG3208]Volvox carteri@jgi_Volca1_121229[RRM1][put-sr][KOG0415]
Chlamydomonas reinhardtii@jgi_Chlre3_116256[RRM1][put-sr]Oryza sativa_japonica_cultivar-group@NP_001068546[RRM1][put-sr][KOG0127]
Oryza sativa_japonica_cultivar-group@NP_001067091[RRM1][put-sr][SR][SCL30b]Oryza sativa_japonica_cultivar-group@NP_001046448[RRM1][put-sr][SR][SCL30a]
Ricinus communis@27383_m000159[RRM1][put-sr][KOG0127]Medicago truncatula@IMGA_CR962128_15_2[RRM1][put-sr]
Arabidopsis thaliana@NP_567021[RRM1][put-sr][SR][KOG0122][SCL30]Physcomitrella patens@jgi_Phypa1_1_141868[RRM1]
Physcomitrella patens@jgi_Phypa1_1_108464[RRM1][put-sr]Oryza sativa_japonica_cultivar-group@NP_001050168[RRM1][put-sr]
Ricinus communis@29726_m003960[RRM1][put-sr]Arabidopsis thaliana@NP_197382[RRM1][put-sr][SR][KOG0127][SCL28]
Arabidopsis thaliana@NP_187966[RRM1][put-sr][SR][SCL30a]Arabidopsis thaliana@NP_001031195[2][RRM1:100%][put-sr:100%][SR:100%][KOG0110:100%][SR33/SCL33]
Ricinus communis@30084_m000177[RRM1][put-sr]Ricinus communis@27553_m000316[RRM1][put-sr]
Medicago truncatula@IMGA_AC146760_9_2[RRM1][put-sr]Oryza sativa_japonica_cultivar-group@NP_001060372[RRM1][put-sr][SR][SCL25]
Oryza sativa_japonica_cultivar-group@NP_001050213[RRM1][put-sr][KOG4207]Aureococcus anophagefferens@jgi_Auran1_9018[RRM1]
Aureococcus anophagefferens@jgi_Auran1_17889[RRM1][KOG4207]Theileria parva_strain_Muguga@XP_765374[RRM2]
Aedes aegypti@AAEL010807-PA[RRM1][put-sr][KOG1080]Oryzias latipes@ENSORLP00000016244[RRM1][KOG1080]
Tetraodon nigroviridis@GSTENP00000272001[RRM1]Mus musculus@ENSMUSP00000098297[RRM1]Eutheria@ENSBTAP00000022553[3][RRM1:100%*][KOG1080:100%*]Macaca mulatta@ENSMMUP00000016612[RRM1]
Ostreococcus tauri@jgi_Ostta4_7793[RRM1][KOG0108]Ostreococcus lucimarinus@jgi_Ost9901_3_9858[RRM1][KOG0108]
Cyanidioschyzon merolae@gnl_CMER_CML202C[RRM1][put-sr]Aureococcus anophagefferens@jgi_Auran1_17068[RRM1][KOG4207]
Tribolium castaneum@XP_970765[RRM2][KOG0127]Ostreococcus lucimarinus@jgi_Ost9901_3_8174[RRM1][KOG4207]
Zea mays@20810_m000015_AZM5_89637[2][RRM1:100%][put-sr:50%][SR:50%][KOG4207:100%][SC35a]Oryza sativa_japonica_cultivar-group@NP_001050263[RRM1][put-sr][SR][KOG4207][SC35c]
Zea mays@8925_m000027_AZM5_1178[RRM1][KOG4207]Oryza sativa_japonica_cultivar-group@NP_001062094[RRM1][put-sr][SR][KOG0415][SC35a]
Physcomitrella patens@jgi_Phypa1_1_122960[RRM1][put-sr][KOG4207]Physcomitrella patens@jgi_Phypa1_1_172957[RRM1][put-sr][KOG0415]
Oryza sativa_japonica_cultivar-group@NP_001060322[RRM1][put-sr][SR][KOG4207][SC35b]Medicago truncatula@IMGA_AC144459_24_2[2][RRM1:100%][put-sr:100%][KOG4207:100%]
Ricinus communis@29581_m000256[RRM1][put-sr][KOG4207]Arabidopsis thaliana@NP_201225[2][RRM1:100%][put-sr:100%][SR:100%][KOG4207:100%][SC35]
Neurospora crassa_OR74A@XP_965346[RRM1][KOG0110]Nitrosococcus oceani_ATCC_19707@YP_344593[RRM1][PROK]
Methylococcus capsulatus_str._Bath@YP_113294[RRM1][PROK]Cryptosporidium parvum_Iowa_II@XP_626081[RRM1][KOG0122]
Volvox carteri@jgi_Volca1_103546[RRM1][KOG0116]Chlamydomonas reinhardtii@jgi_Chlre3_184151[RRM1][KOG0921]
Thalassiosira pseudonana@jgi_Thaps3_20223[RRM1][KOG0108]Phaeodactylum tricornutum@jgi_Phatr2_8269[RRM1][KOG0108]
Thalassiosira pseudonana@jgi_Thaps3_20266[RRM1][KOG4207]Phaeodactylum tricornutum@jgi_Phatr2_8270[RRM1][KOG4207]
Aureococcus anophagefferens@jgi_Auran1_9404[RRM1][KOG0122]Aureococcus anophagefferens@jgi_Auran1_9375[RRM1][KOG0122]
Leishmania infantum_JPCM5@XP_001468615[RRM1]Yarrowia lipolytica@XP_503515[RRM1][KOG0122]
Ustilago maydis_521@XP_760099[RRM1][KOG0122]Schizosaccharomyces pombe_972h-@NP_595727[RRM1][KOG0122]
Aspergillus fumigatus_Af293@XP_755320[RRM1][KOG0122]Neurospora crassa_OR74A@XP_962716[RRM1][KOG0122]
Gibberella zeae_PH-1@XP_385241[RRM1][KOG0122]Caenorhabditis elegans@F22B5_2[RRM1][KOG0122]
Theileria parva_strain_Muguga@XP_765841[RRM1][KOG0122]Plasmodium falciparum_3D7@XP_001349368[RRM1][KOG0122]
Dictyostelium discoideum_AX4@XP_641693[RRM1][KOG0122]Pichia stipitis_CBS_6054@XP_001388004[RRM1][KOG0122]
Debaryomyces hansenii_CBS767@XP_458660[RRM1][KOG0122]Candida glabrata_CBS138@XP_446998[RRM1][KOG0122]
Saccharomyces cerevisiae@YDR429C[RRM1][KOG0122]Ashbya gossypii_ATCC_10895@NP_984285[RRM1][KOG0122]
Chlamydomonas reinhardtii@jgi_Chlre3_112621[RRM1][KOG0122]Physcomitrella patens@jgi_Phypa1_1_164814[RRM1][KOG0122]Physcomitrella patens@jgi_Phypa1_1_196691[RRM1][KOG0122]
Ostreococcus tauri@jgi_Ostta4_5527[RRM1][KOG0122]Ostreococcus lucimarinus@jgi_Ost9901_3_6420[RRM1][KOG0122]
Medicago truncatula@IMGA_AC144431_18_2[RRM1][KOG0122]Ricinus communis@29973_m000409[RRM1][KOG0122]
Oryza sativa_japonica_cultivar-group@NP_001048346[RRM1][KOG0122]Oryza sativa_japonica_cultivar-group@NP_001048347[RRM1][KOG0122]
Medicago truncatula@IMGA_AC174277_12_1[2][RRM1:100%][KOG0122:100%]Arabidopsis thaliana@NP_196219[RRM1][TIF3][KOG0122][TIF3]
Arabidopsis thaliana@NP_187747[RRM1][TIF3][KOG0122][TIF3]Phytophthora ramorum@jgi_Phyra1_1_79758[RRM1][KOG0122]
Phytophthora sojae@jgi_Physo1_1_108333[RRM1][KOG0122]Phaeodactylum tricornutum@jgi_Phatr2_16281[RRM1][KOG0122]
Thalassiosira pseudonana@jgi_Thaps3_32790[RRM1][KOG0122]Aureococcus anophagefferens@jgi_Auran1_9314[2][RRM1:100%][KOG0585:50%][.KOG0122:50%]
Cyanidioschyzon merolae@gnl_CMER_CMH159C[RRM1][KOG0122]Strongylocentrotus purpuratus@XP_791582[2][RRM1:100%][KOG0122:100%]
Ciona intestinalis@ENSCINP00000000359[RRM1][KOG0122]
SC35 "plant"
SCL
SRrp
N2
Fig. S14
139
0.15
98
92
100
96
62
52
97 98
86 50
95
55 89
52
100
67
58 72
74
69 52 57
53
83
50
94
86
100
92
100
55 52
89
100 99
74
64
63
92
96 80
Aureococcus anophagefferens@jgi_Auran1_17018[RRM1][KOG0111]Ostreococcus lucimarinus@jgi_Ost9901_3_43898[RRM1][KOG0121]
Ostreococcus tauri@jgi_Ostta4_21085[RRM1][KOG0121]Thalassiosira pseudonana@jgi_Thaps3_19374[RRM1][KOG0121]
Phaeodactylum tricornutum@jgi_Phatr2_13520[RRM1][KOG0121]Encephalitozoon cuniculi_GB-M1@NP_597585[RRM1][KOG0121]
Cryptosporidium parvum_Iowa_II@XP_627536[RRM1][KOG0121]Trypanosoma brucei_TREU927@XP_845318[RRM1][KOG0121]
Leishmania infantum_JPCM5@XP_001466901[RRM1][KOG0121]Theileria parva_strain_Muguga@XP_766484[RRM1][KOG0121]
Volvox carteri@jgi_Volca1_79141[RRM1][KOG0121]Chlamydomonas reinhardtii@jgi_Chlre3_169371[RRM1][KOG0121]
Erinaceus europaeus@ENSEEUP00000004164[RRM1][KOG0121]Equus caballus@XP_001492661[RRM1][KOG0121]Canis familiaris@ENSCAFP00000026571[RRM1][KOG0121]
Phytophthora ramorum@jgi_Phyra1_1_46906[RRM1][KOG0121]Caenorhabditis elegans@F26A3_2[RRM1][KOG0121]
Drosophila melanogaster@CG12357-PA[RRM1][KOG0121]Anopheles gambiae@AGAP002547-PA[RRM1][KOG0121]
Aedes aegypti@AAEL006135-PA[RRM1][KOG0121]Oryza sativa_japonica_cultivar-group@NP_001047412[RRM1][KOG0121]Ricinus communis@29983_m003140[RRM1][KOG0121]
Arabidopsis thaliana@NP_199233[2][RRM1:100%][KOG0121:100%]Dictyostelium discoideum_AX4@XP_637361[RRM1][KOG0121]
Schizosaccharomyces pombe_972h-@NP_596414[RRM1][KOG0121]Gibberella zeae_PH-1@XP_385664[RRM1][KOG0121]
Aspergillus fumigatus_Af293@XP_755191[RRM1][KOG0121]Plasmodium falciparum_3D7@XP_001351463[RRM1][KOG0121]
Cyanidioschyzon merolae@gnl_CMER_CMQ282C[RRM1][KOG0121]Pichia stipitis_CBS_6054@XP_001387884[RRM1][KOG0121]
Debaryomyces hansenii_CBS767@XP_458582[RRM1][KOG0121]Kluyveromyces lactis@XP_451996[RRM1][KOG0121]
Candida glabrata_CBS138@XP_445241[RRM1][KOG0121]Saccharomyces cerevisiae@YPL178W[RRM1][KOG0121]
Ashbya gossypii_ATCC_10895@NP_985498[RRM1][KOG0121]Ciona savignyi@ENSCSAVP00000009906[RRM1][KOG0121]
Ciona intestinalis@ENSCINP00000006257[2][RRM1:100%][KOG0121:100%]Strongylocentrotus purpuratus@XP_001187788[2][RRM1:100%][KOG0121:100%]
Nasonia vitripennis@XP_001600470[RRM1][KOG0121]Nasonia vitripennis@XP_001608109[RRM1][KOG0121]
Tribolium castaneum@XP_975066[RRM1][KOG0121]Apis mellifera@XP_397316[RRM1][KOG0121]
Xenopus tropicalis@ENSXETP00000041997[RRM1][KOG0121]Gallus gallus@ENSGALP00000009225[RRM1][KOG0121]
Oryzias latipes@ENSORLP00000014087[RRM1][KOG0121]Danio rerio@ENSDARP00000020688[RRM1][KOG0121]
Gasterosteus aculeatus@ENSGACP00000008263[RRM1][KOG0121]Tetraodon nigroviridis@GSTENP00011485001[RRM1][KOG0121]
Takifugu rubripes@SINFRUP00000128783[RRM1][KOG0121]Eutheria@ENSBTAP00000011684[11][RRM1:100%**][KOG0121:100%**]Sorex araneus@ENSSARP00000012929[RRM1][KOG0121]Loxodonta africana@ENSLAFP00000005354[RRM1][KOG0121]
Cavia porcellus@ENSCPOP00000002703[RRM1][KOG0121]Oryctolagus cuniculus@ENSOCUP00000012352[RRM1][KOG0121]
Spermophilus tridecemlineatus@ENSSTOP00000001416[RRM1][KOG0121]Gallus gallus@ENSGALP00000011061[RRM1][KOG0121]
Monodelphis domestica@ENSMODP00000029243[RRM1][KOG0121]Monodelphis domestica@ENSMODP00000019849[RRM1][KOG0121]Monodelphis domestica@ENSMODP00000034858[2][RRM1:100%][KOG0121:100%]
Yarrowia lipolytica@XP_500351[RRM2][KOG0123]Drosophila melanogaster@CG5442-PB[RRM1][put-sr][SR][KOG4207][SC35]
Tribolium castaneum@XP_969931[RRM1][put-sr]Apis mellifera@XP_393352[RRM1][put-sr]Anopheles gambiae@AGAP009742-PA[RRM1][put-sr][KOG4207]
Aedes aegypti@AAEL010340-PB[2][RRM1:100%][put-sr:100%][KOG4207:100%]Caenorhabditis elegans@EEED8_7b[2][RRM1:100%][put-sr:50%][SR:100%][KOG4207:50%][CeSC35/rsp-4]
Strongylocentrotus purpuratus@XP_001180179[4][RRM1:100%*][KOG4207:100%*]Strongylocentrotus purpuratus@XP_785989[2][RRM1:100%][put-sr:100%][KOG4207:100%]
Ciona savignyi@ENSCSAVP00000015651[RRM1][put-sr][KOG4207]Ciona intestinalis@ENSCINP00000008678[RRM1][put-sr][KOG4207]
Rattus norvegicus@ENSRNOP00000045342[2][RRM1:100%][KOG4207:100%]Mus musculus@ENSMUSP00000078984[RRM1][KOG4207]
Percomorpha@ENSGACP00000004058[2][RRM1:100%][put-sr:100%][SR:100%][SC35]Takifugu rubripes@SINFRUP00000176738[RRM1][put-sr][SR][KOG4207][SC35]Oryzias latipes@ENSORLP00000023350[RRM1][put-sr][SR][KOG4368][SC35]
Oryzias latipes@ENSORLP00000001513[RRM1][put-sr][SR][KOG4207][SC35]Clupeocephala@ENSDARP00000074623[3][RRM1:100%*][put-sr:100%*][SR:67%][KOG4207:100%*][SC35]
Danio rerio@ENSDARP00000015569[RRM1][put-sr][SR][KOG4207][SC35]Xenopus tropicalis@ENSXETP00000054042[RRM1][put-sr][SR][SC35]
Macaca mulatta@ENSMMUP00000010035[RRM1][put-sr][SR][SRp46]Homo sapiens@ENSP00000381889[RRM1][put-sr][KOG4207]
Bos taurus@ENSBTAP00000012614[2][RRM1:100%][put-sr:100%][KOG4207:100%]Mammalia@ENSBTAP00000024299[19][RRM1:100%**][put-sr:95%**][SR:100%**][KOG4368:74%**][.KOG4207:26%*][SC35]
Dasypus novemcinctus@ENSDNOP00000000330[RRM1][put-sr][SR][KOG4368][SC35]Erinaceus europaeus@ENSEEUP00000008808[RRM1][put-sr][SR][SC35]
Homo sapiens@ENSP00000350877[RRM1][KOG4207]Pan troglodytes@ENSPTRP00000032751[RRM1][KOG4207]
Macaca mulatta@ENSMMUP00000034012[RRM1][SR][KOG4207][SC35]Cryptosporidium parvum_Iowa_II@XP_628282[RRM1][put-sr][KOG4207]
Plasmodium falciparum_3D7@XP_001347950[RRM1][KOG4207]Plasmodium falciparum_3D7@XP_001351591[RRM1]
Cryptosporidium parvum_Iowa_II@XP_627626[RRM1][put-sr][KOG0111]Volvox carteri@jgi_Volca1_120666[RRM1][put-sr]
Chlamydomonas reinhardtii@jgi_Chlre3_188086[RRM1][put-sr]Volvox carteri@jgi_Volca1_73973[RRM1][put-sr][KOG4207]
Chlamydomonas reinhardtii@jgi_Chlre3_113900[RRM1][KOG4207]Ciona savignyi@ENSCSAVP00000008618[RRM1][put-sr][KOG0111]
SC35
Fig. S14
140
0.10
100
77
52
83
100
67 88
79
53
76
57
59
100
Volvox carteri@jgi_Volca1_105177[RRM1][put-sr][KOG0462]Phytophthora sojae@jgi_Physo1_1_138873[RRM1][put-sr][KOG1611]
Phytophthora ramorum@jgi_Phyra1_1_78424[RRM1][put-sr]Physcomitrella patens@jgi_Phypa1_1_166555[RRM1][put-sr]Physcomitrella patens@jgi_Phypa1_1_105411[RRM1][put-sr]
Oryza sativa_japonica_cultivar-group@NP_001054414[RRM1][put-sr][KOG0117]Oryza sativa_japonica_cultivar-group@NP_001045458[RRM1][put-sr]
Ricinus communis@30169_m006358[RRM1][put-sr]Arabidopsis thaliana@NP_173107[2][RRM1:100%][put-sr:100%][SR:100%][SR45]
Dictyostelium discoideum_AX4@XP_636445[RRM1][put-sr]Ciona savignyi@ENSCSAVP00000002175[RRM1][put-sr]
Ciona intestinalis@ENSCINP00000028346[RRM1][put-sr]Caenorhabditis elegans@K02F3_11_2[2][RRM1:100%][put-sr:100%][KOG4209:100%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569824[RRM1][put-sr]Schizosaccharomyces pombe_972h-@NP_596549[RRM1][put-sr]
Magnaporthe grisea_70-15@XP_001522188[RRM1][put-sr]Neurospora crassa_OR74A@XP_958016[RRM1][put-sr]
Gibberella zeae_PH-1@XP_388712[RRM1]Strongylocentrotus purpuratus@XP_800344[2][RRM1:100%][put-sr:100%][KOG4209:100%]
Nasonia vitripennis@XP_001604831[RRM1][put-sr][KOG1311]Apis mellifera@XP_624099[RRM1][put-sr]
Tribolium castaneum@XP_975044[RRM1][put-sr][KOG4209]Anopheles gambiae@AGAP009570-PA[RRM1][put-sr][KOG4209]
Drosophila melanogaster@CG16788-PA[RRM1][put-sr]Drosophila melanogaster@CG41105-PC[RRM1][put-sr]
Gasterosteus aculeatus@ENSGACP00000014885[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Takifugu rubripes@SINFRUP00000147394[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Oryzias latipes@ENSORLP00000010076[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Danio rerio@ENSDARP00000016052[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Oryzias latipes@ENSORLP00000023176[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Tetraodon nigroviridis@GSTENP00014231001[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Gasterosteus aculeatus@ENSGACP00000007466[2][RRM1:100%][put-sr:100%][RNPS1:50%][KOG4209:100%][RNPS1]
Gallus gallus@ENSGALP00000015093[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Xenopus tropicalis@ENSXETP00000052845[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Bos taurus@ENSBTAP00000043081[RRM1][put-sr][KOG4209]Rattus norvegicus@ENSRNOP00000045977[RRM1][put-sr][KOG4209]
Rattus norvegicus@ENSRNOP00000038996[RRM1][put-sr][KOG4209]Eutheria@ENSBTAP00000013151[18][RRM1:100%**][put-sr:100%**][RNPS1:100%**][KOG4209:100%**][RNPS1]
Monodelphis domestica@ENSMODP00000019828[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Rattus norvegicus@ENSRNOP00000046403[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Rattus norvegicus@ENSRNOP00000011681[RRM1][put-sr][KOG4209]Mus musculus@ENSMUSP00000057332[RRM1][put-sr][KOG4209]
RNPS1
SR45
Fig. S15
141
0.11
76
74
51 70
89
100
100
76 87
87
60
86
70
100 62
59 60
Volvox carteri@jgi_Volca1_105177[RRM1][put-sr][KOG0462]Physcomitrella patens@jgi_Phypa1_1_105411[RRM1][put-sr]
Physcomitrella patens@jgi_Phypa1_1_166555[RRM1][put-sr]Oryza sativa_japonica_cultivar-group@NP_001054414[RRM1][put-sr][KOG0117]
Oryza sativa_japonica_cultivar-group@NP_001045458[RRM1][put-sr]Ricinus communis@30169_m006358[RRM1][put-sr]Arabidopsis thaliana@NP_173107[2][RRM1:100%][put-sr:100%][SR:100%][SR45]
Dictyostelium discoideum_AX4@XP_636445[RRM1][put-sr]Ciona savignyi@ENSCSAVP00000002175[RRM1][put-sr]
Ciona intestinalis@ENSCINP00000028346[RRM1][put-sr]Caenorhabditis elegans@K02F3_11_2[2][RRM1:100%][put-sr:100%][KOG4209:100%]
Cryptococcus neoformans_var._neoformans_JEC21@XP_569824[RRM1][put-sr]Schizosaccharomyces pombe_972h-@NP_596549[RRM1][put-sr]
Phytophthora sojae@jgi_Physo1_1_138873[RRM1][put-sr][KOG1611]Phytophthora ramorum@jgi_Phyra1_1_78424[RRM1][put-sr]
Magnaporthe grisea_70-15@XP_001522188[RRM1][put-sr]Neurospora crassa_OR74A@XP_958016[RRM1][put-sr]
Gibberella zeae_PH-1@XP_388712[RRM1]Strongylocentrotus purpuratus@XP_800344[2][RRM1:100%][put-sr:100%][KOG4209:100%]
Nasonia vitripennis@XP_001604831[RRM1][put-sr][KOG1311]Apis mellifera@XP_624099[RRM1][put-sr]
Drosophila melanogaster@CG16788-PA[RRM1][put-sr]Drosophila melanogaster@CG41105-PC[RRM1][put-sr]
Tribolium castaneum@XP_975044[RRM1][put-sr][KOG4209]Anopheles gambiae@AGAP009570-PA[RRM1][put-sr][KOG4209]
Gallus gallus@ENSGALP00000015093[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Xenopus tropicalis@ENSXETP00000052845[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Oryzias latipes@ENSORLP00000023176[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Tetraodon nigroviridis@GSTENP00014231001[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Gasterosteus aculeatus@ENSGACP00000007466[2][RRM1:100%][put-sr:100%][RNPS1:50%][KOG4209:100%][RNPS1]Danio rerio@ENSDARP00000016052[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Oryzias latipes@ENSORLP00000010076[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Takifugu rubripes@SINFRUP00000147394[RRM1][put-sr][RNPS1][KOG4209][RNPS1]Gasterosteus aculeatus@ENSGACP00000014885[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Bos taurus@ENSBTAP00000043081[RRM1][put-sr][KOG4209]Rattus norvegicus@ENSRNOP00000038996[RRM1][put-sr][KOG4209]
Rattus norvegicus@ENSRNOP00000045977[RRM1][put-sr][KOG4209]Monodelphis domestica@ENSMODP00000019828[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Eutheria@ENSBTAP00000013151[18][RRM1:100%**][put-sr:100%**][RNPS1:100%**][KOG4209:100%**][RNPS1]Rattus norvegicus@ENSRNOP00000046403[RRM1][put-sr][RNPS1][KOG4209][RNPS1]
Rattus norvegicus@ENSRNOP00000011681[RRM1][put-sr][KOG4209]Mus musculus@ENSMUSP00000057332[RRM1][put-sr][KOG4209]
SR45
RNPS1
Fig. S16
142
51
75 50
80
92 91
75
58 67
65
56 76
67 80
76
66 66
61
81
63
Danio rerio@ENSDARP00000002874[RRM2][put-sr][KOG0105]Theria@ENSBTAP00000046374[8][RRM2:100%**][put-sr:100%**][SR:100%**][KOG0105:100%**][ASF/SF2]
Oryzias latipes@ENSORLP00000005758[RRM2][put-sr][SR][KOG0105][ASF/SF2]Takifugu rubripes@SINFRUP00000151768[RRM2][put-sr][SR][KOG0105][ASF/SF2]Tetraodontidae@SINFRUP00000136750[2][RRM2:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]
Gasterosteus aculeatus@ENSGACP00000027276[RRM2][put-sr][SR][KOG0105][ASF/SF2]Xenopus tropicalis@ENSXETP00000019608[RRM2][put-sr][SR][KOG0105][ASF/SF2]Euteleostomi@ENSDARP00000074866[6][RRM1:67%*][.RRM2:33%][put-sr:100%*][SR:100%*][KOG0105:100%*][ASF/SF2]
Gasterosteus aculeatus@ENSGACP00000014666[RRM2][SR][KOG0105][ASF/SF2]Ornithorhynchus anatinus@ENSOANP00000011650[RRM1][SR][KOG0105][ASF/SF2]Eutheria@ENSBTAP00000019644[10][RRM2:90%**][.RRM1:10%][SR:100%**][KOG0105:100%**][ASF/SF2]
Macaca mulatta@ENSMMUP00000004343[RRM2][SR][KOG0105][ASF/SF2]Mus musculus@ENSMUSP00000103553[RRM2][SR][KOG0105][ASF/SF2]
Rattus norvegicus@ENSRNOP00000052565[RRM2][SR][KOG0105][ASF/SF2]Schizosaccharomyces pombe_972h-@NP_594570[RRM2][put-sr][KOG0106]
Danio rerio@ENSDARP00000084873[2][RRM2:100%][put-sr:100%][KOG0106:100%]Takifugu rubripes@SINFRUP00000132279[RRM2][put-sr][KOG0106]Eutheria@ENSBTAP00000015408[22][RRM2:95%***][.RRM1:5%][put-sr:100%***][SR:100%***][KOG0106:50%**][.KOG0105:50%**][SRp40]Tetrapoda@ENSGALP00000015326[6][RRM2:100%*][put-sr:100%*][SR:100%*][KOG0106:83%*][.KOG0105:17%][SRp40]
Xenopus tropicalis@ENSXETP00000038885[RRM2][put-sr][KOG0106]Gallus gallus@ENSGALP00000015427[RRM2][put-sr][KOG0106]
Danio rerio@ENSDARP00000043311[RRM2][put-sr][KOG0106]Tetraodontidae@SINFRUP00000169885[2][RRM2:100%][put-sr:100%][KOG0106:100%]
Oryzias latipes@ENSORLP00000011623[RRM2][put-sr][KOG0106]Gasterosteus aculeatus@ENSGACP00000015556[RRM2][put-sr][KOG0106]Ciona intestinalis@ENSCINP00000014783[RRM2][put-sr][KOG0106]
Strongylocentrotus purpuratus@XP_001180940[2][RRM2:100%][put-sr:100%][KOG0106:100%]Tribolium castaneum@XP_969451[RRM2][put-sr][KOG0105]
Ciona intestinalis@ENSCINP00000016525[RRM2][put-sr][KOG0106]Ciona intestinalis@ENSCINP00000010229[3][RRM2:100%*][put-sr:100%*][KOG0106:100%*]
Ciona savignyi@ENSCSAVP00000004366[3][RRM2:100%*][put-sr:100%*][KOG0106:100%*]Tribolium castaneum@XP_966697[RRM2][put-sr][KOG0106]
Apis mellifera@XP_391860[RRM2][put-sr][KOG0105]Nasonia vitripennis@XP_001603815[2][RRM2:100%][put-sr:100%][KOG0105:100%]Drosophila melanogaster@CG10851-PA[3][RRM2:100%*][put-sr:100%*][SR:100%*][KOG0105:67%][.KOG0106:33%][SRp55]
Aedes aegypti@AAEL012621-PA[RRM2][put-sr][KOG0105]Anopheles gambiae@AGAP004592-PA[RRM2][put-sr][KOG0105]
Gallus gallus@ENSGALP00000002147[2][RRM1:50%][.RRM2:50%][put-sr:100%][SR:100%][KOG0106:50%][.KOG0105:50%][SRp75]Afrotheria@ENSETEP00000007936[2][RRM1:50%][.RRM2:50%][put-sr:100%][SR:100%][KOG0106:50%][.KOG0105:50%][SRp75]Mammalia@ENSBTAP00000017699[17][RRM2:59%**][.RRM1:41%*][put-sr:100%**][SR:88%**][KOG0105:53%**][.KOG0106:41%*][SRp75]
Danio rerio@ENSDARP00000025299[RRM2][put-sr][KOG0105]Tetraodontidae@SINFRUP00000181560[3][RRM2:67%][.RRM4:33%][put-sr:100%*][KOG0598:100%*]
Gasterosteus aculeatus@ENSGACP00000003112[RRM2][put-sr][KOG0106]Oryzias latipes@ENSORLP00000011823[2][RRM2:100%][put-sr:100%][KOG0106:100%]
Xenopus tropicalis@ENSXETP00000054329[RRM2][put-sr][KOG0105]Danio rerio@ENSDARP00000095990[2][RRM2:100%][put-sr:100%][SR:50%][KOG0105:100%][SRp55]
Xenopus tropicalis@ENSXETP00000031474[2][RRM2:100%][put-sr:100%][KOG0105:100%]Amniota@ENSGALP00000001460[3][RRM1:67%][.RRM2:33%][put-sr:100%*][SR:100%*][KOG0105:100%*][SRp55]Cavia porcellus@ENSCPOP00000010577[RRM2][put-sr][SR][KOG0106][SRp55]
Otolemur garnettii@ENSOGAP00000012965[RRM1][put-sr][SR][KOG0105][SRp55]Theria@ENSBTAP00000011240[18][RRM1:50%**][.RRM2:50%**][put-sr:100%**][SR:94%**][KOG0105:78%**][.KOG0106:22%*][SRp55]
Echinops telfairi@ENSETEP00000005046[RRM2][put-sr][SR][KOG0105][SRp55]Oryzias latipes@ENSORLP00000004399[RRM2][put-sr][KOG0105]
Tetraodon nigroviridis@GSTENP00022576001[RRM2][put-sr][KOG3766]Takifugu rubripes@SINFRUP00000158023[RRM2][put-sr][KOG0105]
Gasterosteus aculeatus@ENSGACP00000008087[3][RRM2:100%*][put-sr:100%*][KOG0105:100%*]Danio rerio@ENSDARP00000022089[RRM2][put-sr][KOG0105]
RRM2
RRM2
SRp40
SRp55
SRp75
Fig. S17
143
69 52 87
51
53 50 92
66
100
60
60
58
53
100
98
99
59
53
83
95
64 72
96
98 62
71 59
95100
73
91 91
79 82
71
99
88
93
62
50
51
77
76
69
95
79
100
60
64
51 51
74
95
79 73
92
61 71
74
50
Ciona savignyi@ENSCSAVP00000001354[2][RRM1:50%][ RRM3:50%][KOG4212:100%]Rattus norvegicus@ENSRNOP00000007103[2][RRM3:100%][KOG4212:100%]Mus musculus@ENSMUSP00000106126[4][RRM3:100%*][KOG4212:100%*]
Cavia porcellus@ENSCPOP00000009504[RRM2][KOG4212]Amniota@ENSBTAP00000035742[18][RRM3:89%**][.RRM1:6%][.RRM2:6%][KOG4212:100%**]Otolemur garnettii@ENSOGAP00000009767[RRM3][KOG4212]
Xenopus tropicalis@ENSXETP00000039881[RRM3][KOG4212]Gasterosteus aculeatus@ENSGACP00000022130[2][RRM3:100%][KOG4212:100%]
Oryzias latipes@ENSORLP00000003410[3][RRM3:100%*][KOG4212:100%*]Danio rerio@ENSDARP00000076939[3][RRM3:67%][.RRM1:33%][KOG4212:100%*]Takifugu rubripes@SINFRUP00000133120[RRM3][KOG4212]
Tetraodon nigroviridis@GSTENP00018073001[RRM1][KOG4212]Xenopus tropicalis@ENSXETP00000003694[5][RRM3:100%*][KOG4212:100%*]
Gallus gallus@ENSGALP00000000511[2][RRM3:100%][hnRNP:50%][KOG4212:100%][hnRNP_M]Danio rerio@ENSDARP00000082808[2][RRM3:50%][.RRM2:50%][KOG4212:100%]
Gasterosteus aculeatus@ENSGACP00000013576[2][RRM3:100%][KOG4212:100%]Oryzias latipes@ENSORLP00000006803[RRM3][KOG4212]
Tetraodontidae@SINFRUP00000183106[2][RRM3:50%][.RRM2:50%][KOG4212:100%]Mammalia@ENSMODP00000004659[5][RRM1:40%][.RRM3:40%][.RRM2:20%][hnRNP:100%*][KOG4212:100%*][hnRNP_M]
Cavia porcellus@ENSCPOP00000013686[RRM2][hnRNP][KOG4212][hnRNP_M]Tupaia belangeri@ENSTBEP00000007557[RRM3][hnRNP][KOG4212][hnRNP_M]
Sorex araneus@ENSSARP00000000242[RRM3][hnRNP][KOG4212][hnRNP_M]Eutheria@ENSBTAP00000028022[21][RRM3:86%**][.RRM2:14%*][hnRNP:90%**][KOG4212:100%***][HNRP_M]Otolemur garnettii@ENSOGAP00000002890[RRM3][hnRNP][KOG4212][hnRNP_M]
Bos taurus@ENSBTAP00000047141[2][RRM2:100%][KOG4212:100%]Rattus norvegicus@ENSRNOP00000056410[3][RRM3:100%*][hnRNP:100%*][KOG4212:100%*][hnRNP_M]
Loxodonta africana@ENSLAFP00000011385[RRM2][hnRNP][KOG4212][hnRNP_M]Felis catus@ENSFCAP00000014117[RRM3][hnRNP][KOG4212][hnRNP_M]
Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM1][KOG4212]Trypanosoma brucei_TREU927@XP_827596[RRM1][KOG4212]Leishmania infantum_JPCM5@XP_001465100[RRM1][KOG4212]
Thalassiosira pseudonana@jgi_Thaps3_2921[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_7426[RRM1]
Chlamydomonas reinhardtii@jgi_Chlre3_184854[RRM1]Volvox carteri@jgi_Volca1_103054[RRM1][KOG0055]
Volvox carteri@jgi_Volca1_109965[RRM1][KOG4212]Volvox carteri@jgi_Volca1_103054[RRM2][KOG0055]
Aureococcus anophagefferens@jgi_Auran1_32583[RRM1][KOG0123]Aureococcus anophagefferens@jgi_Auran1_32583[RRM2][KOG0123]
Thalassiosira pseudonana@jgi_Thaps3_37126[RRM1][KOG0123]Trypanosoma brucei_TREU927@XP_823301[RRM1][KOG0921]
Cyanidioschyzon merolae@gnl_CMER_CMM217C[RRM1][KOG4212]Plasmodium falciparum_3D7@XP_001347353[RRM1][KOG4212]
Cryptosporidium parvum_Iowa_II@XP_628165[RRM1][KOG4212]Phytophthora ramorum@jgi_Phyra1_1_75500[RRM2][KOG0123]
Phytophthora sojae@jgi_Physo1_1_141148[RRM2][KOG0123]Phaeodactylum tricornutum@jgi_Phatr2_51303[RRM1][KOG4212]
Cyanidioschyzon merolae@gnl_CMER_CMM078C[RRM1][KOG4212]Phytophthora ramorum@jgi_Phyra1_1_75500[RRM1][KOG0123]
Phytophthora sojae@jgi_Physo1_1_141148[RRM1][KOG0123]Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM1][put-sr][KOG0147]
Yarrowia lipolytica@XP_503927[RRM1][put-sr][KOG4212]Neurospora crassa_OR74A@XP_959532[RRM1][put-sr][KOG4212]
Aspergillus fumigatus_Af293@XP_751108[RRM1][put-sr][KOG4212]Schizosaccharomyces pombe_972h-@NP_594207[RRM1][KOG4212]
Strongylocentrotus purpuratus@XP_001187716[4][RRM1:100%*][put-sr:100%*][KOG4212:50%][.KOG4661:50%]Drosophila melanogaster@CG9373-PA[RRM1][KOG4212]
Tribolium castaneum@XP_974319[RRM1][KOG4212]Nasonia vitripennis@XP_001603370[RRM1][KOG4212]
Apis mellifera@XP_395436[RRM1][KOG4212]Aedes aegypti@AAEL003670-PA[RRM1][KOG4212]
Anopheles gambiae@AGAP001460-PA[RRM1][KOG4212]Ciona intestinalis@ENSCINP00000006201[RRM1][KOG4212]
Ciona savignyi@ENSCSAVP00000001355[RRM1][KOG4212]Ciona savignyi@ENSCSAVP00000001356[RRM1][put-sr][KOG4212]
Takifugu rubripes@SINFRUP00000183106[RRM1][KOG4212]Gasterosteus aculeatus@ENSGACP00000013583[2][RRM1:100%][KOG4212:100%]
Danio rerio@ENSDARP00000082808[RRM1][KOG4212]Oryzias latipes@ENSORLP00000006803[RRM1][KOG4212]Rattus norvegicus@ENSRNOP00000048850[RRM1][hnRNP][KOG4212][hnRNP_M]
Rattus norvegicus@ENSRNOP00000010809[RRM1][hnRNP][KOG4212][hnRNP_M]Rattus norvegicus@ENSRNOP00000056410[RRM1][hnRNP][KOG4212][hnRNP_M]
Gallus gallus@ENSGALP00000000509[2][RRM1:100%][hnRNP:50%][KOG4212:100%]Theria@ENSCAFP00000027344[24][RRM1:100%***][hnRNP:92%***][KOG4212:100%***][hnRNP_M]
Myotis lucifugus@ENSMLUP00000006124[RRM1][hnRNP][KOG4212][hnRNP_M]Monodelphis domestica@ENSMODP00000004247[RRM1][hnRNP][KOG4212][HNRP_M]Bos taurus@ENSBTAP00000011559[RRM1][hnRNP][KOG4212][hnRNP_M]
Xenopus tropicalis@ENSXETP00000039881[RRM1][KOG4212]Danio rerio@ENSDARP00000076939[RRM1][KOG4212]
Danio rerio@ENSDARP00000076941[RRM1][KOG4212]Oryzias latipes@ENSORLP00000003410[RRM1][KOG4212]
Oryzias latipes@ENSORLP00000003405[2][RRM1:100%][KOG4212:100%]Takifugu rubripes@SINFRUP00000133120[RRM1][KOG4212]
Tetraodon nigroviridis@GSTENP00018074001[RRM1][KOG4212]Gasterosteus aculeatus@ENSGACP00000022128[RRM1][KOG4212]
Gasterosteus aculeatus@ENSGACP00000022130[RRM1][KOG4212]Eutheria@ENSBTAP00000035744[2][RRM1:100%][KOG4212:100%]
Otolemur garnettii@ENSOGAP00000009767[RRM1][KOG4212]Amniota@ENSBTAP00000035742[23][RRM1:100%***][KOG4212:100%***]
Loxodonta africana@ENSLAFP00000010861[RRM1][KOG4212]Monodelphis domestica@ENSMODP00000003337[RRM1][KOG4212]
Ornithorhynchus anatinus@ENSOANP00000011737[2][RRM1:100%][KOG4212:100%]Theileria parva_strain_Muguga@XP_766728[RRM2][KOG0124]
Plasmodium falciparum_3D7@XP_001347332[RRM2][put-sr][KOG0105]Phytophthora ramorum@jgi_Phyra1_1_84100[RRM2][KOG0105]
Phytophthora sojae@jgi_Physo1_1_136493[RRM2][put-sr][KOG0105]Phytophthora ramorum@jgi_Phyra1_1_75301[RRM2][put-sr][KOG0105]
Plasmodium falciparum_3D7@XP_001347501[RRM2][put-sr][KOG0105]Theileria parva_strain_Muguga@XP_766386[RRM2][put-sr][KOG0105]
Strongylocentrotus purpuratus@XP_788257[2][RRM1:100%][put-sr:100%][KOG0105:100%]Aedes aegypti@AAEL006473-PA[RRM2][put-sr][KOG0105]
Drosophila melanogaster@CG6987-PA[RRM2][put-sr][KOG0105]Anopheles gambiae@AGAP010496-PA[RRM2][put-sr][KOG0105]
Nasonia vitripennis@XP_001605411[RRM2][put-sr][KOG0105]Apis mellifera@XP_393525[RRM2][put-sr][KOG0105]
Tribolium castaneum@XP_967263[RRM2][put-sr][KOG0105]Ciona savignyi@ENSCSAVP00000005983[RRM1][put-sr][KOG0105]
Ciona intestinalis@ENSCINP00000000458[RRM1][put-sr][KOG0105]Ciona savignyi@ENSCSAVP00000010348[2][RRM2:100%][put-sr:100%][KOG0105:100%]Ciona intestinalis@ENSCINP00000015147[RRM2][put-sr][KOG0105]Caenorhabditis elegans@Y111B2A_18_2[3][RRM2:100%*][put-sr:100%*][SR:100%*][KOG0105:100%*][CeSF2/ASF/rsp-3]
Xenopus tropicalis@ENSXETP00000026703[RRM2][put-sr][SR][KOG0105][SRp30c]Bos taurus@ENSBTAP00000016997[RRM2][put-sr][SR][KOG0105][SRp30c]Eutheria@ENSCAFP00000015146[11][RRM2:55%*][.RRM1:45%*][put-sr:100%**][SR:91%**][KOG0105:100%**][SRp30c]Catarrhini@ENSP00000229390[3][RRM2:67%][.RRM1:33%][put-sr:100%*][SR:100%*][KOG0105:100%*][SRp30c]Tupaia belangeri@ENSTBEP00000007356[RRM2][put-sr][SR][KOG0105][SRp30c]Monodelphis domestica@ENSMODP00000003831[RRM2][put-sr][SR][KOG0105][SRp30c]
Gasterosteus aculeatus@ENSGACP00000022358[2][RRM2:100%][put-sr:100%][KOG0105:100%]Danio rerio@ENSDARP00000091488[RRM2][put-sr][KOG0105]
Danio rerio@ENSDARP00000002874[RRM2][put sr][KOG0105]
RRM3
hnRNP M
RRM1
hnRNP M
RRM2
ASF-like
AnimalFig. S17
144
68
81
99
83 72
57 86
100
81
64
100
97
61
64
73
61
70
91
78
74 88
93
89
70
83
99
100
50
98
100
50 70
53 51
62
81
87
69 70
57 71
64
51
95
85 77
92
80
61
67 64
63
100
82
98 97
92
Apis mellifera@XP 001121250[RRM1][KOG0533]Nasonia vitripennis@XP_001605125[RRM1][KOG0433]
Tribolium castaneum@XP_971598[RRM1][KOG0533]Aedes aegypti@AAEL005114-PA[2][RRM1:100%][KOG0533:100%]
Anopheles gambiae@AGAP006733-PA[RRM1][KOG0533]Ciona savignyi@ENSCSAVP00000005567[RRM1][KOG0533]
Ciona intestinalis@ENSCINP00000024858[RRM1][KOG0533]Gasterosteus aculeatus@ENSGACP00000024021[3][RRM1:100%*][KOG0533:100%*]
Oryzias latipes@ENSORLP00000002010[RRM1][KOG0533]Takifugu rubripes@SINFRUP00000132916[RRM1][KOG0533]
Tetraodon nigroviridis@GSTENP00026384001[RRM1][KOG0533]Tetraodon nigroviridis@GSTENP00007343001[RRM1][KOG0533]Myotis lucifugus@ENSMLUP00000006845[RRM1][KOG0533]
Myotis lucifugus@ENSMLUP00000013791[RRM1][KOG0533]Myotis lucifugus@ENSMLUP00000008945[4][RRM1:100%*][KOG0533:100%*]
Myotis lucifugus@ENSMLUP00000014758[2][RRM1:100%][KOG0533:100%]Tetrapoda@ENSBTAP00000011202[16][RRM1:100%**][KOG0533:100%**]Homo sapiens@ENSP00000383553[RRM1][KOG0533]
Mus musculus@ENSMUSP00000080242[RRM1][KOG0533]Gasterosteus aculeatus@ENSGACP00000017621[RRM1][put-sr][KOG0533]
Oryzias latipes@ENSORLP00000015435[RRM1][KOG0533]Tetraodon nigroviridis@GSTENP00021828001[RRM1][KOG0533]
Takifugu rubripes@SINFRUP00000169188[RRM1][KOG0533]Trypanosoma brucei_TREU927@XP_827596[RRM2][KOG4212]
Leishmania infantum_JPCM5@XP_001465100[RRM2][KOG4212]Debaryomyces hansenii_CBS767@XP_462023[RRM1][put-sr][KOG0123]
Pichia stipitis_CBS_6054@XP_001386572[RRM1][put-sr][KOG0123]Ashbya gossypii_ATCC_10895@NP_982524[RRM1][KOG0127]
Candida glabrata_CBS138@XP_445179[RRM1][put-sr][KOG0123]Saccharomyces cerevisiae@YCL011C[RRM1][put-sr][KOG0123]
Candida glabrata_CBS138@XP_446962[RRM1][put-sr][KOG0127]Saccharomyces cerevisiae@YNL004W[RRM1][KOG0127]
Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM3][KOG0123]Aureococcus anophagefferens@jgi_Auran1_6342[RRM2][KOG0123]
Schizosaccharomyces pombe_972h-@NP_594207[RRM3][KOG4212]Ustilago maydis_521@XP_759231[RRM3][put-sr][KOG4212]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM3][put-sr][KOG0147]Neurospora crassa_OR74A@XP_959532[RRM3][put-sr][KOG4212]
Aspergillus fumigatus_Af293@XP_751108[RRM3][put-sr][KOG4212]Yarrowia lipolytica@XP_503927[RRM3][put-sr][KOG4212]
Candida albicans_SC5314@XP_888678[RRM2][KOG4212]Debaryomyces hansenii_CBS767@XP_462023[RRM3][put-sr][KOG0123]
Pichia stipitis_CBS_6054@XP_001386572[RRM3][put-sr][KOG0123]Ashbya gossypii_ATCC_10895@NP_982524[RRM3][KOG0127]
Kluyveromyces lactis@XP_453283[RRM2][KOG0123]Saccharomyces cerevisiae@YNL004W[RRM3][KOG0127]
Saccharomyces cerevisiae@YCL011C[RRM3][put-sr][KOG0123]Candida glabrata_CBS138@XP_445179[RRM3][put-sr][KOG0123]
Volvox carteri@jgi_Volca1_109965[RRM2][KOG4212]Chlamydomonas reinhardtii@jgi_Chlre3_126810[RRM1][KOG3070]
Volvox carteri@jgi_Volca1_78979[RRM1][KOG3070]Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM2][KOG4212]
Phytophthora ramorum@jgi_Phyra1_1_75500[RRM3][KOG0123]Phytophthora sojae@jgi_Physo1_1_141148[RRM3][KOG0123]
Thalassiosira pseudonana@jgi_Thaps3_37126[RRM2][KOG0123]Phaeodactylum tricornutum@jgi_Phatr2_51303[RRM2][KOG4212]
Ostreococcus tauri@jgi_Ostta4_7882[RRM1]Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM1][KOG0123]
Yarrowia lipolytica@XP_503927[RRM2][put-sr][KOG4212]Strongylocentrotus purpuratus@XP_001188339[4][RRM2:100%*][put-sr:100%*][KOG4661:50%][.KOG4212:50%]
Ciona savignyi@ENSCSAVP00000001355[2][RRM2:100%][put-sr:50%][KOG4212:100%]Ciona intestinalis@ENSCINP00000006201[2][RRM1:50%][.RRM2:50%][KOG4212:100%]
Caenorhabditis elegans@C25A1_4_2[2][RRM2:100%][put-sr:100%][KOG4212:100%]Apocrita@XP_395436[2][RRM2:100%][KOG4212:100%]
Tribolium castaneum@XP_974319[RRM2][KOG4212]Drosophila melanogaster@CG9373-PA[RRM2][KOG4212]
Aedes aegypti@AAEL003670-PA[RRM2][KOG4212]Anopheles gambiae@AGAP001460-PA[RRM2][KOG4212]
Gasterosteus aculeatus@ENSGACP00000013576[2][RRM2:100%][KOG4212:100%]Danio rerio@ENSDARP00000082789[3][RRM1:67%][.RRM2:33%][KOG4212:100%*]
Oryzias latipes@ENSORLP00000006803[RRM2][KOG4212]Tetraodon nigroviridis@GSTENP00028898001[RRM1][KOG4212]Takifugu rubripes@SINFRUP00000183106[RRM2][KOG4212]
Xenopus tropicalis@ENSXETP00000057903[5][RRM2:100%*][KOG4212:100%*]Gallus gallus@ENSGALP00000000509[2][RRM2:100%][hnRNP:50%][KOG4212:100%]Mammalia@ENSMODP00000032153[4][RRM2:75%*][.RRM1:25%][hnRNP:100%*][KOG4212:100%*][HNRP_M]Eutheria@ENSBTAP00000011559[22][RRM2:86%**][.RRM1:14%*][hnRNP:91%**][KOG4212:100%***][hnRNP_M]
Oryctolagus cuniculus@ENSOCUP00000000477[RRM1][hnRNP][KOG4212][hnRNP_M]Mus musculus@ENSMUSP00000110027[2][RRM2:100%][hnRNP:100%][KOG4212:100%][HNRP_M]
Tetraodon nigroviridis@GSTENP00018074001[RRM2][KOG4212]Oryzias latipes@ENSORLP00000003408[3][RRM2:100%*][KOG4212:100%*]
Takifugu rubripes@SINFRUP00000133120[RRM2][KOG4212]Gasterosteus aculeatus@ENSGACP00000022130[2][RRM2:100%][KOG4212:100%]
Danio rerio@ENSDARP00000076941[2][RRM2:100%][KOG4212:100%]Xenopus tropicalis@ENSXETP00000039881[RRM2][KOG4212]
Ornithorhynchus anatinus@ENSOANP00000011736[2][RRM2:100%][KOG4212:100%]Myotis lucifugus@ENSMLUP00000006206[RRM1][KOG4212]
Sorex araneus@ENSSARP00000002953[RRM2][KOG4212]Amniota@ENSBTAP00000035742[26][RRM2:92%***][.RRM1:8%][KOG4212:100%***]Spermophilus tridecemlineatus@ENSSTOP00000006938[RRM2][KOG4212]Monodelphis domestica@ENSMODP00000003337[RRM2][KOG4212]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572539[4][RRM2:100%*][KOG4212:100%*]Pichia stipitis_CBS_6054@XP_001386572[RRM2][put-sr][KOG0123]
Candida albicans_SC5314@XP_888678[RRM1][KOG4212]Debaryomyces hansenii_CBS767@XP_462023[RRM2][put-sr][KOG0123]
Ustilago maydis_521@XP_758699[RRM2][KOG4212]Cryptococcus neoformans_var._neoformans_JEC21@XP_567941[4][RRM1:100%*][KOG4212:100%*]
Ustilago maydis_521@XP_758699[RRM1][KOG4212]Ustilago maydis_521@XP_759231[RRM2][put-sr][KOG4212]
Schizosaccharomyces pombe_972h-@NP_594207[RRM2][KOG4212]Plasmodium falciparum_3D7@XP_001347353[RRM2][KOG4212]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM2][put-sr][KOG0147]Neurospora crassa_OR74A@XP_959532[RRM2][put-sr][KOG4212]
Aspergillus fumigatus_Af293@XP_751108[RRM2][put-sr][KOG4212]Saccharomyces cerevisiae@YNL004W[RRM2][KOG0127]
Ashbya gossypii_ATCC_10895@NP_982524[RRM2][KOG0127]Kluyveromyces lactis@XP_453283[RRM1][KOG0123]
Candida glabrata_CBS138@XP_446962[RRM2][put-sr][KOG0127]Saccharomyces cerevisiae@YCL011C[RRM2][put-sr][KOG0123]
Candida glabrata_CBS138@XP_445179[RRM2][put-sr][KOG0123]Volvox carteri@jgi_Volca1_103054[RRM3][KOG0055]
Chlamydomonas reinhardtii@jgi_Chlre3_95535[RRM2]Cyanidioschyzon merolae@gnl_CMER_CMM078C[RRM2][KOG4212]
Strongylocentrotus purpuratus@XP_786244[2][RRM3:100%][put-sr:100%][KOG4212:100%]Drosophila melanogaster@CG9373-PA[RRM3][KOG4212]
Anopheles gambiae@AGAP001460-PA[RRM3][KOG4212]Nasonia vitripennis@XP_001603370[RRM3][KOG4212]
Apis mellifera@XP_395436[RRM3][KOG4212]Ciona intestinalis@ENSCINP00000006201[RRM3][KOG4212]
Ciona savignyi@ENSCSAVP00000001354[2][RRM1:50%][.RRM3:50%][KOG4212:100%]
RRM2
hnRNP M
Fig. S17
145
0.13
98
71
52
80
81
62 92
100
65
97 99
63 81
100
92 93
61
99
97
70
84 50
59
92 63
62
62
68
78
Cryptosporidium parvum_Iowa_II@XP_628165[RRM2][KOG4212]Neurospora crassa_OR74A@XP_956471[RRM1][KOG0533]
Gibberella zeae_PH-1@XP_391006[RRM1][KOG0533]Schizosaccharomyces pombe_972h-@NP_595715[RRM1][KOG0533]
Ustilago maydis_521@XP_760032[RRM1][KOG0533]Cryptococcus neoformans_var._neoformans_JEC21@XP_572037[RRM1][KOG0533]
Pichia stipitis_CBS_6054@XP_001387082[RRM1][KOG0533]Debaryomyces hansenii_CBS767@XP_462132[RRM1][KOG0533]
Saccharomyces cerevisiae@YDR381W[RRM1][KOG0533]Candida glabrata_CBS138@XP_444903[RRM1][KOG0533]
Kluyveromyces lactis@XP_454070[RRM1][KOG0533]Ashbya gossypii_ATCC_10895@NP_985696[RRM1][KOG0533]
Tupaia belangeri@ENSTBEP00000009485[RRM1][PDIP][KOG0533][PDIP3]Oryzias latipes@ENSORLP00000018556[RRM1]
Tetraodon nigroviridis@GSTENP00020488001[RRM1]Cyanidioschyzon merolae@gnl_CMER_CMH135C[RRM1]
Drosophila melanogaster@CG6961-PA[2][RRM1:100%][KOG0533:100%]Anopheles gambiae@AGAP000924-PA[RRM1]
Aedes aegypti@AAEL008938-PB[2][RRM1:100%]Tribolium castaneum@XP_969371[RRM1]
Nasonia vitripennis@XP_001600231[RRM1]Phytophthora ramorum@jgi_Phyra1_1_97175[RRM1][KOG0533]
Phytophthora sojae@jgi_Physo1_1_157747[RRM1][put-sr][KOG0533]Yarrowia lipolytica@XP_505140[RRM1][KOG0533]
Ustilago maydis_521@XP_757147[RRM1][KOG0533]Aspergillus fumigatus_Af293@XP_753805[RRM1][KOG0533]
Neurospora crassa_OR74A@XP_958422[RRM1][put-sr][KOG0533]Gibberella zeae_PH-1@XP_387031[RRM1][KOG0533]
Theileria parva_strain_Muguga@XP_764636[RRM1]Plasmodium falciparum_3D7@XP_966143[RRM1][KOG0533]
Dictyostelium discoideum_AX4@XP_638266[RRM1][KOG0533]Volvox carteri@jgi_Volca1_90392[RRM1][KOG0533]
Chlamydomonas reinhardtii@jgi_Chlre3_168261[RRM1][KOG0533]Ostreococcus tauri@jgi_Ostta4_36431[RRM1][KOG0533]
Oryza sativa_japonica_cultivar-group@NP_001049725[RRM1][KOG0533]Arabidopsis thaliana@NP_200803[3][RRM1:100%*][FCAFPA:100%*][KOG0533:100%*][AtREF]
Arabidopsis thaliana@NP_195873[RRM1][FCAFPA][KOG0533][AtREF]Ricinus communis@29876_m000260[RRM1][KOG0533]
Oryza sativa_japonica_cultivar-group@NP_001065229[RRM1][KOG0533]Oryza sativa_japonica_cultivar-group@NP_001065221[RRM1][KOG0533]
Physcomitrella patens@jgi_Phypa1_1_172894[RRM1][KOG0533]Physcomitrella patens@jgi_Phypa1_1_129553[RRM1][KOG0533]
Physcomitrella patens@jgi_Phypa1_1_112481[RRM1][KOG0533]Physcomitrella patens@jgi_Phypa1_1_57202[RRM1][KOG0533]
Ricinus communis@29585_m000588[RRM1][KOG0533]Oryza sativa_japonica_cultivar-group@NP_001059250[RRM1][KOG0533]
Oryza sativa_japonica_cultivar-group@NP_001061845[RRM1][KOG0533]Oryza sativa_japonica_cultivar-group@NP_001057314[RRM1][KOG0533]
Ricinus communis@29005_m000257[RRM1][KOG0533]Medicago truncatula@IMGA_CT963094_22_1[RRM1][KOG0533]
Arabidopsis thaliana@NP_001078676[2][RRM1:100%][FCAFPA:100%][KOG0533:100%][AtREF]Arabidopsis thaliana@NP_564871[RRM1][FCAFPA][KOG0533][AtREF]
Drosophila melanogaster@CG1101-PA[RRM1][KOG0533]Strongylocentrotus purpuratus@XP_782040[2][RRM1:100%][KOG0533:100%]
Apis mellifera@XP_001121250[RRM1][KOG0533]
Fig. S17
146
55 63
67 53
93
92 95
81
57
78 83
69
58
74 74
64 80
84
57
65 59
55
90
55
74
Aedes aegypti@AAEL006473-PA[RRM2][put-sr][KOG0105]Theria@ENSBTAP00000046374[8][RRM2:100%**][put-sr:100%**][SR:100%**][KOG0105:100%**][ASF/SF2]
Gasterosteus aculeatus@ENSGACP00000027276[RRM2][put-sr][SR][KOG0105][ASF/SF2]Oryzias latipes@ENSORLP00000005758[RRM2][put-sr][SR][KOG0105][ASF/SF2]Tetraodontidae@SINFRUP00000136750[2][RRM2:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]Takifugu rubripes@SINFRUP00000151768[RRM2][put-sr][SR][KOG0105][ASF/SF2]
Xenopus tropicalis@ENSXETP00000019608[RRM2][put-sr][SR][KOG0105][ASF/SF2]Euteleostomi@ENSDARP00000074866[6][RRM1:67%*][.RRM2:33%][put-sr:100%*][SR:100%*][KOG0105:100%*][ASF/SF2]
Gasterosteus aculeatus@ENSGACP00000014666[RRM2][SR][KOG0105][ASF/SF2]Ornithorhynchus anatinus@ENSOANP00000011650[RRM1][SR][KOG0105][ASF/SF2]Eutheria@ENSBTAP00000019644[10][RRM2:90%**][.RRM1:10%][SR:100%**][KOG0105:100%**][ASF/SF2]
Macaca mulatta@ENSMMUP00000004343[RRM2][SR][KOG0105][ASF/SF2]Rattus norvegicus@ENSRNOP00000052565[RRM2][SR][KOG0105][ASF/SF2]Mus musculus@ENSMUSP00000103553[RRM2][SR][KOG0105][ASF/SF2]
Schizosaccharomyces pombe_972h-@NP_594570[RRM2][put-sr][KOG0106]Danio rerio@ENSDARP00000084873[2][RRM2:100%][put-sr:100%][KOG0106:100%]
Takifugu rubripes@SINFRUP00000132279[RRM2][put-sr][KOG0106]Tetrapoda@ENSGALP00000015326[6][RRM2:100%*][put-sr:100%*][SR:100%*][KOG0106:83%*][.KOG0105:17%][SRp40]Eutheria@ENSBTAP00000015408[22][RRM2:95%***][.RRM1:5%][put-sr:100%***][SR:100%***][KOG0106:50%**][.KOG0105:50%**][SRp40]Xenopus tropicalis@ENSXETP00000038885[RRM2][put-sr][KOG0106]Gallus gallus@ENSGALP00000015427[RRM2][put-sr][KOG0106]
Danio rerio@ENSDARP00000043311[RRM2][put-sr][KOG0106]Tetraodontidae@SINFRUP00000169885[2][RRM2:100%][put-sr:100%][KOG0106:100%]
Oryzias latipes@ENSORLP00000011623[RRM2][put-sr][KOG0106]Gasterosteus aculeatus@ENSGACP00000015556[RRM2][put-sr][KOG0106]
Ciona intestinalis@ENSCINP00000014783[RRM2][put-sr][KOG0106]Tribolium castaneum@XP_969451[RRM2][put-sr][KOG0105]
Ciona intestinalis@ENSCINP00000016525[RRM2][put-sr][KOG0106]Ciona savignyi@ENSCSAVP00000004366[3][RRM2:100%*][put-sr:100%*][KOG0106:100%*]
Ciona intestinalis@ENSCINP00000010229[3][RRM2:100%*][put-sr:100%*][KOG0106:100%*]Tribolium castaneum@XP_966697[RRM2][put-sr][KOG0106]Nasonia vitripennis@XP_001603815[2][RRM2:100%][put-sr:100%][KOG0105:100%]
Apis mellifera@XP_391860[RRM2][put-sr][KOG0105]Drosophila melanogaster@CG10851-PA[3][RRM2:100%*][put-sr:100%*][SR:100%*][KOG0105:67%][.KOG0106:33%][SRp55]
Anopheles gambiae@AGAP004592-PA[RRM2][put-sr][KOG0105]Aedes aegypti@AAEL012621-PA[RRM2][put-sr][KOG0105]
Strongylocentrotus purpuratus@XP_001180940[2][RRM2:100%][put-sr:100%][KOG0106:100%]Gallus gallus@ENSGALP00000002147[2][RRM1:50%][.RRM2:50%][put-sr:100%][SR:100%][KOG0106:50%][.KOG0105:50%][SRp75]Mammalia@ENSBTAP00000017699[17][RRM2:59%**][.RRM1:41%*][put-sr:100%**][SR:88%**][KOG0105:53%**][.KOG0106:41%*][SRp75]Afrotheria@ENSETEP00000007936[2][RRM1:50%][.RRM2:50%][put-sr:100%][SR:100%][KOG0106:50%][.KOG0105:50%][SRp75]
Oryzias latipes@ENSORLP00000011823[2][RRM2:100%][put-sr:100%][KOG0106:100%]Gasterosteus aculeatus@ENSGACP00000003112[RRM2][put-sr][KOG0106]
Tetraodontidae@SINFRUP00000181560[3][RRM2:67%][.RRM4:33%][put-sr:100%*][KOG0598:100%*]Danio rerio@ENSDARP00000025299[RRM2][put-sr][KOG0105]
Xenopus tropicalis@ENSXETP00000054329[RRM2][put-sr][KOG0105]Xenopus tropicalis@ENSXETP00000031474[2][RRM2:100%][put-sr:100%][KOG0105:100%]
Danio rerio@ENSDARP00000095990[2][RRM2:100%][put-sr:100%][SR:50%][KOG0105:100%][SRp55]Oryzias latipes@ENSORLP00000004399[RRM2][put-sr][KOG0105]
Tetraodon nigroviridis@GSTENP00022576001[RRM2][put-sr][KOG3766]Takifugu rubripes@SINFRUP00000158023[RRM2][put-sr][KOG0105]
Gasterosteus aculeatus@ENSGACP00000008087[3][RRM2:100%*][put-sr:100%*][KOG0105:100%*]Danio rerio@ENSDARP00000022089[RRM2][put-sr][KOG0105]
Amniota@ENSGALP00000001460[3][RRM1:67%][.RRM2:33%][put-sr:100%*][SR:100%*][KOG0105:100%*][SRp55]Cavia porcellus@ENSCPOP00000010577[RRM2][put-sr][SR][KOG0106][SRp55]Theria@ENSBTAP00000011240[18][RRM1:50%**][.RRM2:50%**][put-sr:100%**][SR:94%**][KOG0105:78%**][.KOG0106:22%*][SRp55]
Otolemur garnettii@ENSOGAP00000012965[RRM1][put-sr][SR][KOG0105][SRp55]Echinops telfairi@ENSETEP00000005046[RRM2][put-sr][SR][KOG0105][SRp55]
RRM2
SRp40
SRp55
SRp75
RRM2
Fig. S18
147
88 51
92
60 61
55 61
63 74
52 78
58
66
74
98
99
100
98
87
58
65 76
94
98 71
70 67
86100
79
84 91
79 83
53 60
99
89
86
60
54
91
77
67
94
97
90 99
83
100
52
95 62
58
72
91 73
61
71 55
71
94
Gasterosteus aculeatus@ENSGACP00000013576[2][RRM2:100%][KOG4212:100%]Danio rerio@ENSDARP00000082789[3][RRM1:67%][.RRM2:33%][KOG4212:100%*]
Oryzias latipes@ENSORLP00000006803[RRM2][KOG4212]Tetraodon nigroviridis@GSTENP00028898001[RRM1][KOG4212]Takifugu rubripes@SINFRUP00000183106[RRM2][KOG4212]
Xenopus tropicalis@ENSXETP00000057903[5][RRM2:100%*][KOG4212:100%*]Gallus gallus@ENSGALP00000000509[2][RRM2:100%][hnRNP:50%][KOG4212:100%]Mammalia@ENSMODP00000032153[4][RRM2:75%*][.RRM1:25%][hnRNP:100%*][KOG4212:100%*][HNRP_M]Oryctolagus cuniculus@ENSOCUP00000000477[RRM1][hnRNP][KOG4212][hnRNP_M]Eutheria@ENSBTAP00000011559[22][RRM2:86%**][.RRM1:14%*][hnRNP:91%**][KOG4212:100%***][hnRNP_M]
Mus musculus@ENSMUSP00000110027[2][RRM2:100%][hnRNP:100%][KOG4212:100%][HNRP_M]Tetraodon nigroviridis@GSTENP00018074001[RRM2][KOG4212]
Takifugu rubripes@SINFRUP00000133120[RRM2][KOG4212]Oryzias latipes@ENSORLP00000003408[3][RRM2:100%*][KOG4212:100%*]Gasterosteus aculeatus@ENSGACP00000022130[2][RRM2:100%][KOG4212:100%]
Danio rerio@ENSDARP00000076941[2][RRM2:100%][KOG4212:100%]Xenopus tropicalis@ENSXETP00000039881[RRM2][KOG4212]
Ornithorhynchus anatinus@ENSOANP00000011736[2][RRM2:100%][KOG4212:100%]Myotis lucifugus@ENSMLUP00000006206[RRM1][KOG4212]Amniota@ENSBTAP00000035742[26][RRM2:92%***][.RRM1:8%][KOG4212:100%***]Sorex araneus@ENSSARP00000002953[RRM2][KOG4212]
Spermophilus tridecemlineatus@ENSSTOP00000006938[RRM2][KOG4212]Monodelphis domestica@ENSMODP00000003337[RRM2][KOG4212]
Trypanosoma brucei_TREU927@XP_823301[RRM1][KOG0921]Cyanidioschyzon merolae@gnl_CMER_CMM217C[RRM1][KOG4212]
Thalassiosira pseudonana@jgi_Thaps3_2921[RRM1]Phaeodactylum tricornutum@jgi_Phatr2_7426[RRM1]
Volvox carteri@jgi_Volca1_103054[RRM1][KOG0055]Chlamydomonas reinhardtii@jgi_Chlre3_184854[RRM1]
Volvox carteri@jgi_Volca1_109965[RRM1][KOG4212]Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM1][KOG4212]
Trypanosoma brucei_TREU927@XP_827596[RRM1][KOG4212]Leishmania infantum_JPCM5@XP_001465100[RRM1][KOG4212]
Aureococcus anophagefferens@jgi_Auran1_32583[RRM1][KOG0123]Volvox carteri@jgi_Volca1_103054[RRM2][KOG0055]
Aureococcus anophagefferens@jgi_Auran1_32583[RRM2][KOG0123]Thalassiosira pseudonana@jgi_Thaps3_37126[RRM1][KOG0123]
Phaeodactylum tricornutum@jgi_Phatr2_51303[RRM1][KOG4212]Cyanidioschyzon merolae@gnl_CMER_CMM078C[RRM1][KOG4212]
Phytophthora sojae@jgi_Physo1_1_141148[RRM1][KOG0123]Phytophthora ramorum@jgi_Phyra1_1_75500[RRM1][KOG0123]
Phytophthora ramorum@jgi_Phyra1_1_75500[RRM2][KOG0123]Phytophthora sojae@jgi_Physo1_1_141148[RRM2][KOG0123]
Plasmodium falciparum_3D7@XP_001347353[RRM1][KOG4212]Cryptosporidium parvum_Iowa_II@XP_628165[RRM1][KOG4212]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM1][put-sr][KOG0147]Schizosaccharomyces pombe_972h-@NP_594207[RRM1][KOG4212]
Yarrowia lipolytica@XP_503927[RRM1][put-sr][KOG4212]Neurospora crassa_OR74A@XP_959532[RRM1][put-sr][KOG4212]
Aspergillus fumigatus_Af293@XP_751108[RRM1][put-sr][KOG4212]Strongylocentrotus purpuratus@XP_001187716[4][RRM1:100%*][put-sr:100%*][KOG4212:50%][.KOG4661:50%]
Drosophila melanogaster@CG9373-PA[RRM1][KOG4212]Tribolium castaneum@XP_974319[RRM1][KOG4212]
Nasonia vitripennis@XP_001603370[RRM1][KOG4212]Apis mellifera@XP_395436[RRM1][KOG4212]
Anopheles gambiae@AGAP001460-PA[RRM1][KOG4212]Aedes aegypti@AAEL003670-PA[RRM1][KOG4212]
Ciona intestinalis@ENSCINP00000006201[RRM1][KOG4212]Ciona savignyi@ENSCSAVP00000001356[RRM1][put-sr][KOG4212]
Ciona savignyi@ENSCSAVP00000001355[RRM1][KOG4212]Takifugu rubripes@SINFRUP00000183106[RRM1][KOG4212]
Gasterosteus aculeatus@ENSGACP00000013583[2][RRM1:100%][KOG4212:100%]Oryzias latipes@ENSORLP00000006803[RRM1][KOG4212]
Danio rerio@ENSDARP00000082808[RRM1][KOG4212]Rattus norvegicus@ENSRNOP00000048850[RRM1][hnRNP][KOG4212][hnRNP_M]
Rattus norvegicus@ENSRNOP00000056410[RRM1][hnRNP][KOG4212][hnRNP_M]Rattus norvegicus@ENSRNOP00000010809[RRM1][hnRNP][KOG4212][hnRNP_M]Monodelphis domestica@ENSMODP00000004247[RRM1][hnRNP][KOG4212][HNRP_M]Bos taurus@ENSBTAP00000011559[RRM1][hnRNP][KOG4212][hnRNP_M]
Theria@ENSCAFP00000027344[24][RRM1:100%***][hnRNP:92%***][KOG4212:100%***][hnRNP_M]Myotis lucifugus@ENSMLUP00000006124[RRM1][hnRNP][KOG4212][hnRNP_M]Gallus gallus@ENSGALP00000000509[2][RRM1:100%][hnRNP:50%][KOG4212:100%]
Xenopus tropicalis@ENSXETP00000039881[RRM1][KOG4212]Danio rerio@ENSDARP00000076939[RRM1][KOG4212]
Danio rerio@ENSDARP00000076941[RRM1][KOG4212]Oryzias latipes@ENSORLP00000003410[RRM1][KOG4212]
Oryzias latipes@ENSORLP00000003405[2][RRM1:100%][KOG4212:100%]Takifugu rubripes@SINFRUP00000133120[RRM1][KOG4212]
Tetraodon nigroviridis@GSTENP00018074001[RRM1][KOG4212]Gasterosteus aculeatus@ENSGACP00000022128[RRM1][KOG4212]
Gasterosteus aculeatus@ENSGACP00000022130[RRM1][KOG4212]Otolemur garnettii@ENSOGAP00000009767[RRM1][KOG4212]Eutheria@ENSBTAP00000035744[2][RRM1:100%][KOG4212:100%]
Loxodonta africana@ENSLAFP00000010861[RRM1][KOG4212]Amniota@ENSBTAP00000035742[23][RRM1:100%***][KOG4212:100%***]
Ornithorhynchus anatinus@ENSOANP00000011737[2][RRM1:100%][KOG4212:100%]Monodelphis domestica@ENSMODP00000003337[RRM1][KOG4212]
Plasmodium falciparum_3D7@XP_001347353[RRM2][KOG4212]Nasonia vitripennis@XP_001603370[RRM3][KOG4212]
Apis mellifera@XP_395436[RRM3][KOG4212]Drosophila melanogaster@CG9373-PA[RRM3][KOG4212]
Anopheles gambiae@AGAP001460-PA[RRM3][KOG4212]Theileria parva_strain_Muguga@XP_766728[RRM2][KOG0124]
Plasmodium falciparum_3D7@XP_001347332[RRM2][put-sr][KOG0105]Phytophthora ramorum@jgi_Phyra1_1_84100[RRM2][KOG0105]
Phytophthora ramorum@jgi_Phyra1_1_75301[RRM2][put-sr][KOG0105]Phytophthora sojae@jgi_Physo1_1_136493[RRM2][put-sr][KOG0105]
Theileria parva_strain_Muguga@XP_766386[RRM2][put-sr][KOG0105]Plasmodium falciparum_3D7@XP_001347501[RRM2][put-sr][KOG0105]
Danio rerio@ENSDARP00000091488[RRM2][put-sr][KOG0105]Danio rerio@ENSDARP00000002874[RRM2][put-sr][KOG0105]
Gasterosteus aculeatus@ENSGACP00000022358[2][RRM2:100%][put-sr:100%][KOG0105:100%]Xenopus tropicalis@ENSXETP00000026703[RRM2][put-sr][SR][KOG0105][SRp30c]
Monodelphis domestica@ENSMODP00000003831[RRM2][put-sr][SR][KOG0105][SRp30c]Tupaia belangeri@ENSTBEP00000007356[RRM2][put-sr][SR][KOG0105][SRp30c]Eutheria@ENSCAFP00000015146[11][RRM2:55%*][.RRM1:45%*][put-sr:100%**][SR:91%**][KOG0105:100%**][SRp30c]Catarrhini@ENSP00000229390[3][RRM2:67%][.RRM1:33%][put-sr:100%*][SR:100%*][KOG0105:100%*][SRp30c]Bos taurus@ENSBTAP00000016997[RRM2][put-sr][SR][KOG0105][SRp30c]
Caenorhabditis elegans@Y111B2A_18_2[3][RRM2:100%*][put-sr:100%*][SR:100%*][KOG0105:100%*][CeSF2/ASF/rsp-3]Ciona savignyi@ENSCSAVP00000010348[2][RRM2:100%][put-sr:100%][KOG0105:100%]Ciona intestinalis@ENSCINP00000015147[RRM2][put-sr][KOG0105]
Ciona savignyi@ENSCSAVP00000005983[RRM1][put-sr][KOG0105]Ciona intestinalis@ENSCINP00000000458[RRM1][put-sr][KOG0105]
Strongylocentrotus purpuratus@XP_788257[2][RRM1:100%][put-sr:100%][KOG0105:100%]Nasonia vitripennis@XP_001605411[RRM2][put-sr][KOG0105]
Tribolium castaneum@XP_967263[RRM2][put-sr][KOG0105]Apis mellifera@XP_393525[RRM2][put-sr][KOG0105]
Anopheles gambiae@AGAP010496-PA[RRM2][put-sr][KOG0105]Drosophila melanogaster@CG6987-PA[RRM2][put-sr][KOG0105]
Aedes aegypti@AAEL006473 PA[RRM2][put sr][KOG0105] RRM2
ASF-like
Animal
RRM1
hnRNP M
Fig. S18
148
80 75
76
82 56
69
74100
52
77
61
84
96
78
79 94
95
87
73
91
100
98
54
60 91
71
99
97
100
58 62
89 70
100
95
80
92
75 51 88
55 58
52 52 98
95
50
67
56
66
83
87
61
99
73 93
54
70
98
Ciona intestinalis@ENSCINP00000024858[RRM1][KOG0533]Oryzias latipes@ENSORLP00000002010[RRM1][KOG0533]
Gasterosteus aculeatus@ENSGACP00000024021[3][RRM1:100%*][KOG0533:100%*]Takifugu rubripes@SINFRUP00000132916[RRM1][KOG0533]
Tetraodon nigroviridis@GSTENP00007343001[RRM1][KOG0533]Tetraodon nigroviridis@GSTENP00026384001[RRM1][KOG0533]
Strongylocentrotus purpuratus@XP_782040[2][RRM1:100%][KOG0533:100%]Nasonia vitripennis@XP_001605125[RRM1][KOG0433]
Apis mellifera@XP_001121250[RRM1][KOG0533]Tribolium castaneum@XP_971598[RRM1][KOG0533]
Anopheles gambiae@AGAP006733-PA[RRM1][KOG0533]Aedes aegypti@AAEL005114-PA[2][RRM1:100%][KOG0533:100%]
Tetraodon nigroviridis@GSTENP00021828001[RRM1][KOG0533]Mus musculus@ENSMUSP00000080242[RRM1][KOG0533]Gasterosteus aculeatus@ENSGACP00000017621[RRM1][put-sr][KOG0533]
Takifugu rubripes@SINFRUP00000169188[RRM1][KOG0533]Oryzias latipes@ENSORLP00000015435[RRM1][KOG0533]Tetrapoda@ENSBTAP00000011202[16][RRM1:100%**][KOG0533:100%**]Homo sapiens@ENSP00000383553[RRM1][KOG0533]
Myotis lucifugus@ENSMLUP00000006845[RRM1][KOG0533]Myotis lucifugus@ENSMLUP00000013791[RRM1][KOG0533]
Myotis lucifugus@ENSMLUP00000008945[4][RRM1:100%*][KOG0533:100%*]Myotis lucifugus@ENSMLUP00000014758[2][RRM1:100%][KOG0533:100%]
Schizosaccharomyces pombe_972h-@NP_594207[RRM3][KOG4212]Ustilago maydis_521@XP_759231[RRM3][put-sr][KOG4212]
Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM3][put-sr][KOG0147]Neurospora crassa_OR74A@XP_959532[RRM3][put-sr][KOG4212]
Aspergillus fumigatus_Af293@XP_751108[RRM3][put-sr][KOG4212]Yarrowia lipolytica@XP_503927[RRM3][put-sr][KOG4212]
Candida albicans_SC5314@XP_888678[RRM2][KOG4212]Pichia stipitis_CBS_6054@XP_001386572[RRM3][put-sr][KOG0123]
Debaryomyces hansenii_CBS767@XP_462023[RRM3][put-sr][KOG0123]Kluyveromyces lactis@XP_453283[RRM2][KOG0123]
Ashbya gossypii_ATCC_10895@NP_982524[RRM3][KOG0127]Saccharomyces cerevisiae@YNL004W[RRM3][KOG0127]
Saccharomyces cerevisiae@YCL011C[RRM3][put-sr][KOG0123]Candida glabrata_CBS138@XP_445179[RRM3][put-sr][KOG0123]
Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM3][KOG0123]Aureococcus anophagefferens@jgi_Auran1_6342[RRM2][KOG0123]
Trypanosoma brucei_TREU927@XP_827596[RRM2][KOG4212]Leishmania infantum_JPCM5@XP_001465100[RRM2][KOG4212]
Pichia stipitis_CBS_6054@XP_001386572[RRM1][put-sr][KOG0123]Debaryomyces hansenii_CBS767@XP_462023[RRM1][put-sr][KOG0123]
Candida glabrata_CBS138@XP_445179[RRM1][put-sr][KOG0123]Ashbya gossypii_ATCC_10895@NP_982524[RRM1][KOG0127]
Saccharomyces cerevisiae@YCL011C[RRM1][put-sr][KOG0123]Saccharomyces cerevisiae@YNL004W[RRM1][KOG0127]
Candida glabrata_CBS138@XP_446962[RRM1][put-sr][KOG0127]Ostreococcus tauri@jgi_Ostta4_7882[RRM1]
Ostreococcus lucimarinus@jgi_Ost9901_3_27365[RRM1][KOG0123]Volvox carteri@jgi_Volca1_78979[RRM1][KOG3070]
Chlamydomonas reinhardtii@jgi_Chlre3_126810[RRM1][KOG3070]Volvox carteri@jgi_Volca1_109965[RRM2][KOG4212]
Volvox carteri@jgi_Volca1_103054[RRM3][KOG0055]Chlamydomonas reinhardtii@jgi_Chlre3_95535[RRM2]
Cyanidioschyzon merolae@gnl_CMER_CMM078C[RRM2][KOG4212]Ostreococcus lucimarinus@jgi_Ost9901_3_34965[RRM2][KOG4212]
Saccharomyces cerevisiae@YNL004W[RRM2][KOG0127]Kluyveromyces lactis@XP_453283[RRM1][KOG0123]
Ashbya gossypii_ATCC_10895@NP_982524[RRM2][KOG0127]Candida glabrata_CBS138@XP_446962[RRM2][put-sr][KOG0127]
Saccharomyces cerevisiae@YCL011C[RRM2][put-sr][KOG0123]Candida glabrata_CBS138@XP_445179[RRM2][put-sr][KOG0123]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572539[4][RRM2:100%*][KOG4212:100%*]Pichia stipitis_CBS_6054@XP_001386572[RRM2][put-sr][KOG0123]
Debaryomyces hansenii_CBS767@XP_462023[RRM2][put-sr][KOG0123]Candida albicans_SC5314@XP_888678[RRM1][KOG4212]
Yarrowia lipolytica@XP_503927[RRM2][put-sr][KOG4212]Phytophthora sojae@jgi_Physo1_1_141148[RRM3][KOG0123]
Phytophthora ramorum@jgi_Phyra1_1_75500[RRM3][KOG0123]Thalassiosira pseudonana@jgi_Thaps3_37126[RRM2][KOG0123]
Phaeodactylum tricornutum@jgi_Phatr2_51303[RRM2][KOG4212]Schizosaccharomyces pombe_972h-@NP_594207[RRM2][KOG4212]Ustilago maydis_521@XP_758699[RRM2][KOG4212]
Ustilago maydis_521@XP_758699[RRM1][KOG4212]Cryptococcus neoformans_var._neoformans_JEC21@XP_567941[4][RRM1:100%*][KOG4212:100%*]
Ustilago maydis_521@XP_759231[RRM2][put-sr][KOG4212]Cryptococcus neoformans_var._neoformans_JEC21@XP_568231[RRM2][put-sr][KOG0147]
Neurospora crassa_OR74A@XP_959532[RRM2][put-sr][KOG4212]Aspergillus fumigatus_Af293@XP_751108[RRM2][put-sr][KOG4212]
Strongylocentrotus purpuratus@XP_786244[2][RRM3:100%][put-sr:100%][KOG4212:100%]Ciona savignyi@ENSCSAVP00000001354[2][RRM1:50%][.RRM3:50%][KOG4212:100%]
Ciona intestinalis@ENSCINP00000006201[RRM3][KOG4212]Gasterosteus aculeatus@ENSGACP00000022130[2][RRM3:100%][KOG4212:100%]
Tetraodon nigroviridis@GSTENP00018073001[RRM1][KOG4212]Takifugu rubripes@SINFRUP00000133120[RRM3][KOG4212]
Oryzias latipes@ENSORLP00000003410[3][RRM3:100%*][KOG4212:100%*]Danio rerio@ENSDARP00000076939[3][RRM3:67%][.RRM1:33%][KOG4212:100%*]
Rattus norvegicus@ENSRNOP00000007103[2][RRM3:100%][KOG4212:100%]Mus musculus@ENSMUSP00000106126[4][RRM3:100%*][KOG4212:100%*]
Cavia porcellus@ENSCPOP00000009504[RRM2][KOG4212]Amniota@ENSBTAP00000035742[18][RRM3:89%**][.RRM1:6%][.RRM2:6%][KOG4212:100%**]Otolemur garnettii@ENSOGAP00000009767[RRM3][KOG4212]
Xenopus tropicalis@ENSXETP00000039881[RRM3][KOG4212]Danio rerio@ENSDARP00000082808[2][RRM3:50%][.RRM2:50%][KOG4212:100%]
Gasterosteus aculeatus@ENSGACP00000013576[2][RRM3:100%][KOG4212:100%]Tetraodontidae@SINFRUP00000183106[2][RRM3:50%][.RRM2:50%][KOG4212:100%]
Oryzias latipes@ENSORLP00000006803[RRM3][KOG4212]Xenopus tropicalis@ENSXETP00000003694[5][RRM3:100%*][KOG4212:100%*]
Gallus gallus@ENSGALP00000000511[2][RRM3:100%][hnRNP:50%][KOG4212:100%][hnRNP_M]Mammalia@ENSMODP00000004659[5][RRM1:40%][.RRM3:40%][.RRM2:20%][hnRNP:100%*][KOG4212:100%*][hnRNP_M]
Cavia porcellus@ENSCPOP00000013686[RRM2][hnRNP][KOG4212][hnRNP_M]Tupaia belangeri@ENSTBEP00000007557[RRM3][hnRNP][KOG4212][hnRNP_M]
Eutheria@ENSBTAP00000028022[21][RRM3:86%**][.RRM2:14%*][hnRNP:90%**][KOG4212:100%***][HNRP_M]Sorex araneus@ENSSARP00000000242[RRM3][hnRNP][KOG4212][hnRNP_M]
Loxodonta africana@ENSLAFP00000011385[RRM2][hnRNP][KOG4212][hnRNP_M]Felis catus@ENSFCAP00000014117[RRM3][hnRNP][KOG4212][hnRNP_M]
Otolemur garnettii@ENSOGAP00000002890[RRM3][hnRNP][KOG4212][hnRNP_M]Rattus norvegicus@ENSRNOP00000056410[3][RRM3:100%*][hnRNP:100%*][KOG4212:100%*][hnRNP_M]
Bos taurus@ENSBTAP00000047141[2][RRM2:100%][KOG4212:100%]Strongylocentrotus purpuratus@XP_001188339[4][RRM2:100%*][put-sr:100%*][KOG4661:50%][.KOG4212:50%]
Ciona savignyi@ENSCSAVP00000001355[2][RRM2:100%][put-sr:50%][KOG4212:100%]Ciona intestinalis@ENSCINP00000006201[2][RRM1:50%][.RRM2:50%][KOG4212:100%]
Apocrita@XP_395436[2][RRM2:100%][KOG4212:100%]Tribolium castaneum@XP_974319[RRM2][KOG4212]
Caenorhabditis elegans@C25A1_4_2[2][RRM2:100%][put-sr:100%][KOG4212:100%]Drosophila melanogaster@CG9373-PA[RRM2][KOG4212]
Anopheles gambiae@AGAP001460-PA[RRM2][KOG4212]Aedes aegypti@AAEL003670-PA[RRM2][KOG4212]
Gasterosteus aculeatus@ENSGACP00000013576[2][RRM2:100%][KOG4212:100%]
RRM2 and RRM3
hnRNP M
Fig. S18
149
0.14
92
90 91
67 65
94
61
70
85
61 97
100
59
100
97 99
64 63
88
97 58
86 51
62
86
88
71
100 77
71
Cyanidioschyzon merolae@gnl_CMER_CMH135C[RRM1]Cryptosporidium parvum_Iowa_II@XP_628165[RRM2][KOG4212]
Theileria parva_strain_Muguga@XP_764636[RRM1]Plasmodium falciparum_3D7@XP_966143[RRM1][KOG0533]
Yarrowia lipolytica@XP_505140[RRM1][KOG0533]Ustilago maydis_521@XP_757147[RRM1][KOG0533]Aspergillus fumigatus_Af293@XP_753805[RRM1][KOG0533]
Neurospora crassa_OR74A@XP_958422[RRM1][put-sr][KOG0533]Gibberella zeae_PH-1@XP_387031[RRM1][KOG0533]
Neurospora crassa_OR74A@XP_956471[RRM1][KOG0533]Gibberella zeae_PH-1@XP_391006[RRM1][KOG0533]
Schizosaccharomyces pombe_972h-@NP_595715[RRM1][KOG0533]Ustilago maydis_521@XP_760032[RRM1][KOG0533]
Cryptococcus neoformans_var._neoformans_JEC21@XP_572037[RRM1][KOG0533]Pichia stipitis_CBS_6054@XP_001387082[RRM1][KOG0533]
Debaryomyces hansenii_CBS767@XP_462132[RRM1][KOG0533]Saccharomyces cerevisiae@YDR381W[RRM1][KOG0533]
Candida glabrata_CBS138@XP_444903[RRM1][KOG0533]Kluyveromyces lactis@XP_454070[RRM1][KOG0533]
Ashbya gossypii_ATCC_10895@NP_985696[RRM1][KOG0533]Phytophthora sojae@jgi_Physo1_1_157747[RRM1][put-sr][KOG0533]
Phytophthora ramorum@jgi_Phyra1_1_97175[RRM1][KOG0533]Tupaia belangeri@ENSTBEP00000009485[RRM1][PDIP][KOG0533][PDIP3]
Tetraodon nigroviridis@GSTENP00020488001[RRM1]Oryzias latipes@ENSORLP00000018556[RRM1]
Drosophila melanogaster@CG6961-PA[2][RRM1:100%][KOG0533:100%]Tribolium castaneum@XP_969371[RRM1]
Nasonia vitripennis@XP_001600231[RRM1]Anopheles gambiae@AGAP000924-PA[RRM1]
Aedes aegypti@AAEL008938-PB[2][RRM1:100%]Dictyostelium discoideum_AX4@XP_638266[RRM1][KOG0533]
Volvox carteri@jgi_Volca1_90392[RRM1][KOG0533]Chlamydomonas reinhardtii@jgi_Chlre3_168261[RRM1][KOG0533]Ostreococcus tauri@jgi_Ostta4_36431[RRM1][KOG0533]
Oryza sativa_japonica_cultivar-group@NP_001061845[RRM1][KOG0533]Oryza sativa_japonica_cultivar-group@NP_001057314[RRM1][KOG0533]
Ricinus communis@29005_m000257[RRM1][KOG0533]Medicago truncatula@IMGA_CT963094_22_1[RRM1][KOG0533]
Arabidopsis thaliana@NP_001078676[2][RRM1:100%][FCAFPA:100%][KOG0533:100%][AtREF]Arabidopsis thaliana@NP_564871[RRM1][FCAFPA][KOG0533][AtREF]
Arabidopsis thaliana@NP_195873[RRM1][FCAFPA][KOG0533][AtREF]Oryza sativa_japonica_cultivar-group@NP_001049725[RRM1][KOG0533]
Arabidopsis thaliana@NP_200803[3][RRM1:100%*][FCAFPA:100%*][KOG0533:100%*][AtREF]Ricinus communis@29876_m000260[RRM1][KOG0533]
Ricinus communis@29585_m000588[RRM1][KOG0533]Oryza sativa_japonica_cultivar-group@NP_001065221[RRM1][KOG0533]
Oryza sativa_japonica_cultivar-group@NP_001065229[RRM1][KOG0533]Oryza sativa_japonica_cultivar-group@NP_001059250[RRM1][KOG0533]
Physcomitrella patens@jgi_Phypa1_1_172894[RRM1][KOG0533]Physcomitrella patens@jgi_Phypa1_1_129553[RRM1][KOG0533]
Physcomitrella patens@jgi_Phypa1_1_57202[RRM1][KOG0533]Physcomitrella patens@jgi_Phypa1_1_112481[RRM1][KOG0533]
Drosophila melanogaster@CG1101-PA[RRM1][KOG0533]Ciona savignyi@ENSCSAVP00000005567[RRM1][KOG0533]
Ciona intestinalis@ENSCINP00000024858[RRM1][KOG0533]
Fig. S18
150
59
74
80
60
97
70
98 52
50
67
59
88
66
61
100 67
97 52
75
55
79
99
65
73 89
59
75
71
68 92
69
56
71 53
50
92
86
76 97
80 57
57
51
74
85
87
Tribolium castaneum@XP 966697[RRM1][put-sr][KOG0106]Strongylocentrotus purpuratus@XP_001180940[2][RRM1:100%][put-sr:100%][KOG0106:100%]
Oryzias latipes@ENSORLP00000011623[3][RRM1:100%*][put-sr:67%][SR:33%][KOG0106:100%*]Danio rerio@ENSDARP00000043311[RRM1][put-sr][KOG0106]
Gasterosteus aculeatus@ENSGACP00000015556[RRM1][put-sr][KOG0106]Xenopus tropicalis@ENSXETP00000038885[RRM1][put-sr][KOG0106]
Takifugu rubripes@SINFRUP00000169885[RRM1][put-sr][KOG0106]Tetraodon nigroviridis@GSTENP00035800001[RRM1][put-sr][KOG0106]
Sorex araneus@ENSSARP00000000971[RRM1][put-sr][SR][KOG0105][SRp40]Catarrhini@ENSP00000342294[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*][SRp40]
Xenopus tropicalis@ENSXETP00000057107[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][SRp40]Amniota@ENSBTAP00000015408[24][RRM1:100%***][put-sr:96%***][SR:100%***][KOG0106:54%**][.KOG0105:46%**][SRp40]Afrotheria@ENSETEP00000016575[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][SRp40]
Ornithorhynchus anatinus@ENSOANP00000021053[RRM1][put-sr][SR][KOG0106][SRp40]Ornithorhynchus anatinus@ENSOANP00000021052[RRM1][put-sr][SR][KOG0106][SRp40]
Ornithorhynchus anatinus@ENSOANP00000021051[RRM1][put-sr][SR][KOG0105][SRp40]Gasterosteus aculeatus@ENSGACP00000010395[2][RRM1:100%][put-sr:100%][SR:50%][KOG0106:100%][SRp40]
Tetraodontidae@SINFRUP00000132279[2][RRM1:100%][put-sr:50%][SR:50%][KOG0106:100%]Danio rerio@ENSDARP00000069997[3][RRM1:100%*][put-sr:67%][SR:33%][KOG0106:100%*][SRp40]
Theria@ENSBTAP00000017699[12][RRM1:100%**][put-sr:100%**][SR:100%**][KOG0106:50%*][.KOG0105:50%*][SRp75]Myotis lucifugus@ENSMLUP00000013443[RRM1][put-sr][SR][KOG0105][SRp75]
Tetraodon nigroviridis@GSTENP00010110001[RRM1][put-sr][KOG0598]Smegmamorpha@ENSGACP00000003112[3][RRM1:100%*][put-sr:100%*][KOG0106:100%*]
Danio rerio@ENSDARP00000025299[RRM1][put-sr][KOG0105]Danio rerio@ENSDARP00000094522[RRM1][put-sr]
Danio rerio@ENSDARP00000095990[2][RRM1:100%][put-sr:100%][SR:50%][KOG0105:100%][SRp55]Oryzias latipes@ENSORLP00000004399[RRM1][put-sr][KOG0105]Tetraodontidae@SINFRUP00000158023[2][RRM1:100%][put-sr:100%][KOG3766:50%][.KOG0105:50%]
Danio rerio@ENSDARP00000022089[RRM1][put-sr][KOG0105]Gasterosteus aculeatus@ENSGACP00000008092[3][RRM1:100%*][put-sr:100%*][KOG0105:100%*]
Xenopus tropicalis@ENSXETP00000054329[RRM1][put-sr][KOG0105]Monodelphis domestica@ENSMODP00000030967[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:50%][.KOG0105:50%][SRp55]Cavia porcellus@ENSCPOP00000010577[RRM1][put-sr][SR][KOG0106][SRp55]Eutheria@ENSDNOP00000006506[3][RRM1:100%*][put-sr:67%][SR:100%*][KOG0105:67%][.KOG0106:33%][SRp55]
Echinops telfairi@ENSETEP00000005046[RRM1][put-sr][SR][KOG0105][SRp55]Murinae@ENSMUSP00000017065[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp55]
Bos taurus@ENSBTAP00000011240[RRM1][put-sr][SR][KOG0105][SRp55]Oryza sativa_japonica_cultivar-group@NP_001052061[RRM1][put-sr][SR][KOG0106][RSp29]
Arabidopsis thaliana@NP_182184[RRM1][put-sr][SR][KOG0106][RSp31a]Arabidopsis thaliana@NP_567120[RRM1][put-sr][SR][KOG0106][RSp31]
Ricinus communis@29742_m001371[RRM1][KOG0106]Physcomitrella patens@jgi_Phypa1_1_167387[RRM1][put-sr][KOG0106]
Oryza sativa_japonica_cultivar-group@NP_001045729[RRM1][put-sr][SR][KOG0106][RSp33]Zea mays@8514_m000507_c0216K08[RRM1][SR][KOG0106][RSp33]
Zea mays@10633_m000022_AZM5_5503[RRM1][KOG0106]Ricinus communis@30147_m014308[RRM1][put-sr][KOG0106]
Medicago truncatula@IMGA_AC152177_25_1[RRM1][put-sr][KOG0106]Arabidopsis thaliana@NP_851174[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][RSp41]
Arabidopsis thaliana@NP_194280[RRM1][put-sr][SR][KOG0106][RSp40/SRp35]Oryza sativa_japonica_cultivar-group@NP_001055323[RRM1][put-sr][SR][KOG0105][SRp33b]
Oryza sativa_japonica_cultivar-group@NP_001050082[RRM1][put-sr][SR][KOG0105][SRp32]Oryza sativa_japonica_cultivar-group@NP_001060608[RRM1][put-sr][SR][KOG0105][SRp33a]
Arabidopsis thaliana@NP_190512[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp34a]Ricinus communis@29827_m002610[RRM1][put-sr][KOG0105]Medicago truncatula@IMGA_CT868739_2_1[RRM1][put-sr][SR][KOG0105][SRp34a]
Physcomitrella patens@jgi_Phypa1_1_140978[RRM1][put-sr][KOG0105]Physcomitrella patens@jgi_Phypa1_1_205547[RRM1][put-sr][KOG0105]
Physcomitrella patens@jgi_Phypa1_1_113630[RRM1][put-sr][KOG0105]Arabidopsis thaliana@NP_683288[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp30]
Ricinus communis@29986_m001610[RRM1][put-sr][SR][KOG0105][SRp33a]Ricinus communis@30128_m008840[RRM1][put-sr][KOG0105]
Medicago truncatula@IMGA_AC174141_23_1[RRM1][put-sr][KOG0105]Ricinus communis@30128_m008837[RRM1][put-sr][KOG0105]
Medicago truncatula@IMGA_AC144541_27_2[RRM1][put-sr][KOG0105]Medicago truncatula@IMGA_AC134522_46_2[2][RRM1:100%][put-sr:100%][KOG0105:100%]
Arabidopsis thaliana@NP_567235[2][RRM1:100%][put-sr:50%][SR:100%][KOG0105:100%][SRp34b]Arabidopsis thaliana@NP_850933[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0105:100%*][SR1/SRp34]
Xenopus tropicalis@ENSXETP00000026703[RRM1][put-sr][SR][KOG0105][SRp30c]Danio rerio@ENSDARP00000091488[2][RRM1:100%][put-sr:100%][KOG0105:100%]
Takifugu rubripes@SINFRUP00000145791[RRM1][put-sr][SR][KOG0105][SRp30c]Gasterosteus aculeatus@ENSGACP00000022361[2][RRM1:100%][put-sr:100%][KOG0105:100%]
Monodelphis domestica@ENSMODP00000003831[RRM1][put-sr][SR][KOG0105][SRp30c]Mus musculus@ENSMUSP00000031513[RRM1][put-sr][SR][KOG0105][SRp30c]
Bos taurus@ENSBTAP00000016997[RRM1][put-sr][SR][KOG0105][SRp30c]Tupaia belangeri@ENSTBEP00000007356[RRM1][put-sr][SR][KOG0105][SRp30c]Eutheria@ENSCAFP00000015146[7][RRM1:100%*][put-sr:100%*][SR:86%*][KOG0105:100%*][SRp30c]
Myotis lucifugus@ENSMLUP00000009421[RRM1][put-sr][SR][KOG0105][SRp30c]Oryctolagus cuniculus@ENSOCUP00000009368[RRM1][KOG0105]
Tribolium castaneum@XP_967263[RRM1][put-sr][KOG0105]Diptera@AAEL006473-PA[3][RRM1:100%*][put-sr:100%*][KOG0105:100%*]
Apis mellifera@XP_393525[RRM1][put-sr][KOG0105]Nasonia vitripennis@XP_001605411[RRM1][put-sr][KOG0105]
Oryzias latipes@ENSORLP00000006698[RRM1][put-sr][SR][KOG0105][ASF/SF2]Gasterosteus aculeatus@ENSGACP00000027276[RRM1][put-sr][SR][KOG0105][ASF/SF2]
Takifugu rubripes@SINFRUP00000151768[RRM1][put-sr][SR][KOG0105][ASF/SF2]Danio rerio@ENSDARP00000074866[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]
Gasterosteus aculeatus@ENSGACP00000014666[RRM1][SR][KOG0105][ASF/SF2]Oryzias latipes@ENSORLP00000005758[RRM1][put-sr][SR][KOG0105][ASF/SF2]Tetraodontidae@SINFRUP00000136750[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]
Macaca mulatta@ENSMMUP00000004343[RRM1][SR][KOG0105][ASF/SF2]Tetrapoda@ENSBTAP00000019644[17][RRM1:100%**][put-sr:53%**][SR:100%**][KOG0105:100%**][ASF/SF2]
Echinops telfairi@ENSETEP00000004344[RRM1][SR][KOG0105][ASF/SF2]Otolemur garnettii@ENSOGAP00000012982[RRM1][SR][KOG0105][ASF/SF2]
Tupaia belangeri@ENSTBEP00000013333[RRM1][SR][KOG0105][ASF/SF2]
ASF/SF2
SRp30c
ASF-like "plant"
SRp75
SRp40
SRp55
RS
N6
N5
Fig. S19
151
98
100 98
77
59
100 81
80
55
96
92 95
98
93
89
83
57
54 59
95
54 57
82
58
88
65
64
96
68
100 70
66 85
70 50
66
94
68 55
57
91
82 62
63
72
62
95
54
58 77
62
85
64
74
81
98
83
93
81
Oryzias latipes@ENSORLP00000001513[RRM1][put-sr][SR][KOG4207][SC35]Danio rerio@ENSDARP00000015569[RRM1][put-sr][SR][KOG4207][SC35]
Xenopus tropicalis@ENSXETP00000054042[RRM1][put-sr][SR][SC35]Homo sapiens@ENSP00000381889[RRM1][put-sr][KOG4207]
Macaca mulatta@ENSMMUP00000010035[RRM1][put-sr][SR][SRp46]Mammalia@ENSBTAP00000024299[19][RRM1:100%**][put-sr:95%**][SR:100%**][KOG4368:74%**][.KOG4207:26%*][SC35]
Dasypus novemcinctus@ENSDNOP00000000330[RRM1][put-sr][SR][KOG4368][SC35]Erinaceus europaeus@ENSEEUP00000008808[RRM1][put-sr][SR][SC35]
Homo sapiens@ENSP00000350877[RRM1][KOG4207]Macaca mulatta@ENSMMUP00000034012[RRM1][SR][KOG4207][SC35]
Pan troglodytes@ENSPTRP00000032751[RRM1][KOG4207]Chlamydomonas reinhardtii@jgi_Chlre3_188086[RRM1][put-sr]
Volvox carteri@jgi_Volca1_120666[RRM1][put-sr]Chlamydomonas reinhardtii@jgi_Chlre3_113900[RRM1][KOG4207]
Volvox carteri@jgi_Volca1_73973[RRM1][put-sr][KOG4207]Oryza sativa_japonica_cultivar-group@NP_001068546[RRM1][put-sr][KOG0127]
Oryza sativa_japonica_cultivar-group@NP_001067091[RRM1][put-sr][SR][SCL30b]Oryza sativa_japonica_cultivar-group@NP_001046448[RRM1][put-sr][SR][SCL30a]
Ricinus communis@27383_m000159[RRM1][put-sr][KOG0127]Medicago truncatula@IMGA_CR962128_15_2[RRM1][put-sr]
Arabidopsis thaliana@NP_567021[RRM1][put-sr][SR][KOG0122][SCL30]Physcomitrella patens@jgi_Phypa1_1_141868[RRM1]
Physcomitrella patens@jgi_Phypa1_1_108464[RRM1][put-sr]Oryza sativa_japonica_cultivar-group@NP_001050168[RRM1][put-sr]Arabidopsis thaliana@NP_197382[RRM1][put-sr][SR][KOG0127][SCL28]
Ricinus communis@29726_m003960[RRM1][put-sr]Chlamydomonas reinhardtii@jgi_Chlre3_116256[RRM1][put-sr]
Volvox carteri@jgi_Volca1_121229[RRM1][put-sr][KOG0415]Arabidopsis thaliana@NP_187966[RRM1][put-sr][SR][SCL30a]
Arabidopsis thaliana@NP_001031195[2][RRM1:100%][put-sr:100%][SR:100%][KOG0110:100%][SR33/SCL33]Ricinus communis@30084_m000177[RRM1][put-sr]
Ricinus communis@27553_m000316[RRM1][put-sr]Medicago truncatula@IMGA_AC146760_9_2[RRM1][put-sr]
Oryza sativa_japonica_cultivar-group@NP_001050213[RRM1][put-sr][KOG4207]Oryza sativa_japonica_cultivar-group@NP_001060372[RRM1][put-sr][SR][SCL25]
Ciona savignyi@ENSCSAVP00000008618[RRM1][put-sr][KOG0111]Gasterosteus aculeatus@ENSGACP00000018038[RRM1][put-sr]
Danio rerio@ENSDARP00000031512[RRM1][put-sr][KOG0415]Danio rerio@ENSDARP00000091866[RRM1][put-sr]Gasterosteus aculeatus@ENSGACP00000002897[RRM1][put-sr][KOG0415]
Tetraodon nigroviridis@GSTENP00010468001[RRM1][SRrp][KOG4207][SRp38]Oryzias latipes@ENSORLP00000009635[RRM1][SRrp][KOG4207][SRp38]
Takifugu rubripes@SINFRUP00000150947[RRM1][put-sr]Canis familiaris@ENSCAFP00000019234[RRM1][put-sr][SRrp][SRp38]Eutheria@ENSBTAP00000010616[19][RRM1:100%**][put-sr:100%**][SRrp:100%**][KOG0111:58%**][.KOG0415:21%*][SRp38]
Canis familiaris@ENSCAFP00000004604[RRM1][put-sr][SRrp][SRp38]Eutheria@ENSEEUP00000013029[3][RRM1:100%*][put-sr:100%*][SRrp:100%*][SRp38]
Monodelphis domestica@ENSMODP00000016281[RRM1][put-sr][SRrp][SRp38]Rattus norvegicus@ENSRNOP00000011154[2][RRM1:100%][put-sr:100%][SRrp:100%][SRp38]Gallus gallus@ENSGALP00000006566[RRM1][put-sr][SRrp][SRp38]
Xenopus tropicalis@ENSXETP00000011851[RRM1][put-sr]Echinops telfairi@ENSETEP00000001114[RRM1][put-sr]Mus musculus@ENSMUSP00000103794[RRM1][put-sr][SRrp][KOG0111][SRrp35]
Catarrhini@ENSP00000358479[3][RRM1:100%*][put-sr:100%*][SRrp:100%*][SRrp35]Erinaceus europaeus@ENSEEUP00000010036[RRM1][put-sr][SRrp][SRrp35]
Monodelphis domestica@ENSMODP00000022797[RRM1][put-sr][SRrp][SRrp35]Cavia porcellus@ENSCPOP00000009809[RRM1][put-sr][SRrp][SRrp35]
Chlamydomonas reinhardtii@jgi_Chlre3_132362[RRM1][KOG0107]Volvox carteri@jgi_Volca1_121301[RRM1][put-sr][KOG0107]
Chlamydomonas reinhardtii@jgi_Chlre3_192053[RRM1][put-sr][KOG0107]Physcomitrella patens@jgi_Phypa1_1_143810[2][RRM1:100%][KOG0107:100%]
Oryza sativa_japonica_cultivar-group@NP_001048352[RRM1][put-sr][SR][RSZp21b]Oryza sativa_japonica_cultivar-group@NP_001057018[RRM1][put-sr][SR][RSZp21a]Oryza sativa_japonica_cultivar-group@NP_001047400[RRM1][put-sr][SR][KOG0107][RSZp23]
Arabidopsis thaliana@NP_973901[2][RRM1:100%][SR:100%][SRZ21/RSZ21]Arabidopsis thaliana@NP_194886[2][RRM1:100%][put-sr:100%][SR:100%][KOG0107:100%][SRZ22/RSZ22]
Arabidopsis thaliana@NP_180035[RRM1][put-sr][SR][RSZ22a]Ricinus communis@28610_m000073[RRM1][SR][KOG0107][SRZ21/RSZ21]
Ricinus communis@29848_m004475[RRM1][put-sr][SR][SRZ22/RSZ22]Medicago truncatula@IMGA_CR936368_17_2[RRM1][put-sr][KOG0107]
Apis mellifera@XP_001123058[2][RRM1:100%][put-sr:50%][KOG0107:100%]Endopterygota@XP_001599712[6][RRM1:100%*][put-sr:17%][KOG0107:83%*][.KOG2490:17%]
Culicidae@AAEL001356-PA[3][RRM1:100%*][put-sr:100%*][KOG0108:67%][.KOG0107:33%]Drosophila melanogaster@CG1987-PA[RRM1][put-sr][KOG0107]
Drosophila melanogaster@CG17136-PD[4][RRM1:100%*][put-sr:50%][KOG0107:100%*]Percomorpha@ENSGACP00000016280[4][RRM1:100%*][put-sr:100%*][KOG0107:50%][.KOG4368:25%]
Oryzias latipes@ENSORLP00000000921[3][RRM1:100%*][put-sr:100%*][KOG4368:33%][.KOG0107:33%]Danio rerio@ENSDARP00000051184[2][RRM1:100%][put-sr:100%]
Spermophilus tridecemlineatus@ENSSTOP00000003936[RRM1][put-sr]Danio rerio@ENSDARP00000070952[RRM1][SR][KOG0107][9G8]
Gallus gallus@ENSGALP00000038155[RRM1][put-sr][SR][9G8]Rattus norvegicus@ENSRNOP00000011102[RRM1][put-sr][SR][KOG0107][9G8]
Rattus norvegicus@ENSRNOP00000058047[RRM1][put-sr]Mammalia@ENSBTAP00000033048[27][RRM1:100%***][put-sr:78%***][SR:93%***][KOG0107:81%***][9G8]
Xenopus tropicalis@ENSXETP00000054077[2][RRM1:100%][put-sr:100%][SR:100%][9G8]Gallus gallus@ENSGALP00000022386[RRM1][put-sr][SR][9G8]
Monodelphis domestica@ENSMODP00000010787[RRM1][put-sr][SR][KOG0107][9G8]Rattus norvegicus@ENSRNOP00000040587[RRM1][put-sr][SR][KOG0107][9G8]
Canis familiaris@ENSCAFP00000009434[RRM1][put-sr][KOG0107]Apis mellifera@XP_001122800[RRM1][put-sr][KOG0107]
Tribolium castaneum@XP_968789[RRM1][put-sr][KOG4368]Anopheles gambiae@AGAP008303-PA[RRM1][put-sr]
Drosophila melanogaster@CG10203-PA[RRM1][put-sr][SR][KOG0107][9G8]Ciona savignyi@ENSCSAVP00000004510[RRM1][put-sr]Ciona intestinalis@ENSCINP00000022204[2][RRM1:100%][put-sr:100%][KOG0107:100%]
Eutheria@ENSEEUP00000001001[3][RRM1:100%*][put-sr:100%*]Mus musculus@ENSMUSP00000100538[RRM1][put-sr][SR][KOG0107][SRp20]Tetrapoda@ENSBTAP00000004154[28][RRM1:100%***][put-sr:68%**][SR:100%***][KOG0107:100%***][SRp20]
Gasterosteus aculeatus@ENSGACP00000001909[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0107:100%*][SRp20]Takifugu rubripes@SINFRUP00000147448[RRM1][put-sr][SR][KOG0107][SRp20]
Oryzias latipes@ENSORLP00000024888[RRM1][put-sr][SR][KOG0107][SRp20]Danio rerio@ENSDARP00000035207[2][RRM1:100%][put-sr:50%][SR:100%][KOG0107:100%][SRp20]
Oryzias latipes@ENSORLP00000000358[RRM1][put-sr][SR][KOG0107][SRp20]Gasterosteus aculeatus@ENSGACP00000001355[RRM1][put-sr][SR][KOG0107][SRp20]Danio rerio@ENSDARP00000076899[2][RRM1:100%][put-sr:50%][SR:100%][KOG0107:100%][SRp20]Tetraodon nigroviridis@GSTENP00027331001[RRM1][SR][KOG0107][SRp20]
Takifugu rubripes@SINFRUP00000136850[RRM1][SR][KOG0107][SRp20]Arabidopsis thaliana@NP_850280[RRM1][put-sr][SR][KOG0107][RSZ33]
Arabidopsis thaliana@NP_190918[RRM1][put-sr][SR][KOG0107][RSZ32]Oryza sativa_japonica_cultivar-group@NP_001042066[RRM1][put-sr][SR][KOG0109][RSZ37a]
Oryza sativa_japonica_cultivar-group@NP_001054731[RRM1][put-sr][SR][RSZ39]Ricinus communis@29805_m001527[RRM1][put-sr][KOG0109]
Oryza sativa_japonica_cultivar-group@NP_001049771[RRM1][put-sr][SR][KOG0109][RSZ37b]Oryza sativa_japonica_cultivar-group@NP_001054489[RRM1][put-sr][SR][KOG0109][RSZ36]
Nasonia vitripennis@XP_001603815[2][RRM1:100%][put-sr:100%][KOG0105:100%]Tribolium castaneum@XP_969451[RRM1][put-sr][KOG0105]
Aedes aegypti@AAEL000769-PA[RRM1][put-sr][KOG0106]Apis mellifera@XP_391860[RRM1][put-sr][KOG0105]
Diptera@AGAP004592-PA[7][RRM1:100%*][put-sr:71%*][SR:86%*][KOG0105:57%*][.KOG0106:43%*]Tribolium castaneum@XP_966697[RRM1][put sr][KOG0106]
RS2Z "plant"
SRp20
RSZ "plant"
9G8
SRrp
SCL
SC35
N2
N4
N3
Fig. S19
152
0.12 70
96
94 99
67 67
97
64 50 53
91
66 78
67
74
83
99
100
89 99
59
96
99
72 73
60 76
100
66 61
57
57
56 73 87
54
96
56
54
95
70
55
63
77
67
99
98
56 64
66
65
Thalassiosira pseudonana@jgi_Thaps3_19374[RRM1][KOG0121]Phaeodactylum tricornutum@jgi_Phatr2_13520[RRM1][KOG0121]
Volvox carteri@jgi_Volca1_79141[RRM1][KOG0121]Chlamydomonas reinhardtii@jgi_Chlre3_169371[RRM1][KOG0121]
Cyanidioschyzon merolae@gnl_CMER_CMQ282C[RRM1][KOG0121]Oryza sativa_japonica_cultivar-group@NP_001047412[RRM1][KOG0121]
Arabidopsis thaliana@NP_199233[2][RRM1:100%][KOG0121:100%]Ricinus communis@29983_m003140[RRM1][KOG0121]
Dictyostelium discoideum_AX4@XP_637361[RRM1][KOG0121]Schizosaccharomyces pombe_972h-@NP_596414[RRM1][KOG0121]
Aspergillus fumigatus_Af293@XP_755191[RRM1][KOG0121]Gibberella zeae_PH-1@XP_385664[RRM1][KOG0121]
Strongylocentrotus purpuratus@XP_001187788[2][RRM1:100%][KOG0121:100%]Apis mellifera@XP_397316[RRM1][KOG0121]
Tribolium castaneum@XP_975066[RRM1][KOG0121]Ciona intestinalis@ENSCINP00000006257[2][RRM1:100%][KOG0121:100%]
Ciona savignyi@ENSCSAVP00000009906[RRM1][KOG0121]Anopheles gambiae@AGAP002547-PA[RRM1][KOG0121]
Aedes aegypti@AAEL006135-PA[RRM1][KOG0121]Drosophila melanogaster@CG12357-PA[RRM1][KOG0121]
Nasonia vitripennis@XP_001608109[RRM1][KOG0121]Nasonia vitripennis@XP_001600470[RRM1][KOG0121]
Eutheria@ENSBTAP00000011684[11][RRM1:100%**][KOG0121:100%**]Sorex araneus@ENSSARP00000012929[RRM1][KOG0121]
Cavia porcellus@ENSCPOP00000002703[RRM1][KOG0121]Loxodonta africana@ENSLAFP00000005354[RRM1][KOG0121]Spermophilus tridecemlineatus@ENSSTOP00000001416[RRM1][KOG0121]
Oryctolagus cuniculus@ENSOCUP00000012352[RRM1][KOG0121]Monodelphis domestica@ENSMODP00000029243[RRM1][KOG0121]
Monodelphis domestica@ENSMODP00000034858[2][RRM1:100%][KOG0121:100%]Monodelphis domestica@ENSMODP00000019849[RRM1][KOG0121]
Gallus gallus@ENSGALP00000011061[RRM1][KOG0121]Xenopus tropicalis@ENSXETP00000041997[RRM1][KOG0121]
Oryzias latipes@ENSORLP00000014087[RRM1][KOG0121]Danio rerio@ENSDARP00000020688[RRM1][KOG0121]
Takifugu rubripes@SINFRUP00000128783[RRM1][KOG0121]Gasterosteus aculeatus@ENSGACP00000008263[RRM1][KOG0121]
Tetraodon nigroviridis@GSTENP00011485001[RRM1][KOG0121]Volvox carteri@jgi_Volca1_103546[RRM1][KOG0116]
Chlamydomonas reinhardtii@jgi_Chlre3_184151[RRM1][KOG0921]Ustilago maydis_521@XP_760099[RRM1][KOG0122]
Schizosaccharomyces pombe_972h-@NP_595727[RRM1][KOG0122]Aspergillus fumigatus_Af293@XP_755320[RRM1][KOG0122]
Neurospora crassa_OR74A@XP_962716[RRM1][KOG0122]Gibberella zeae_PH-1@XP_385241[RRM1][KOG0122]
Ostreococcus tauri@jgi_Ostta4_5527[RRM1][KOG0122]Ostreococcus lucimarinus@jgi_Ost9901_3_6420[RRM1][KOG0122]
Physcomitrella patens@jgi_Phypa1_1_164814[RRM1][KOG0122]Physcomitrella patens@jgi_Phypa1_1_196691[RRM1][KOG0122]
Oryza sativa_japonica_cultivar-group@NP_001048346[RRM1][KOG0122]Oryza sativa_japonica_cultivar-group@NP_001048347[RRM1][KOG0122]Medicago truncatula@IMGA_AC174277_12_1[2][RRM1:100%][KOG0122:100%]
Arabidopsis thaliana@NP_196219[RRM1][TIF3][KOG0122][TIF3]Arabidopsis thaliana@NP_187747[RRM1][TIF3][KOG0122][TIF3]
Chlamydomonas reinhardtii@jgi_Chlre3_112621[RRM1][KOG0122]Phytophthora ramorum@jgi_Phyra1_1_79758[RRM1][KOG0122]
Phytophthora sojae@jgi_Physo1_1_108333[RRM1][KOG0122]Phaeodactylum tricornutum@jgi_Phatr2_16281[RRM1][KOG0122]
Thalassiosira pseudonana@jgi_Thaps3_32790[RRM1][KOG0122]Aureococcus anophagefferens@jgi_Auran1_9314[2][RRM1:100%][KOG0585:50%][.KOG0122:50%]
Strongylocentrotus purpuratus@XP_791582[2][RRM1:100%][KOG0122:100%]Ciona intestinalis@ENSCINP00000000359[RRM1][KOG0122]
Gasterosteus aculeatus@ENSGACP00000018150[RRM1][KOG0122]Clupeocephala@ENSDARP00000027672[2][RRM1:100%][KOG0122:100%]Tetrapoda@ENSBTAP00000003545[10][RRM1:100%**][KOG0122:100%**]
Takifugu rubripes@SINFRUP00000147763[RRM1][KOG0122]Tetraodon nigroviridis@GSTENP00034383001[RRM1][KOG0122]
Cyanidioschyzon merolae@gnl_CMER_CML202C[RRM1][put-sr]Oryza sativa_japonica_cultivar-group@NP_001060322[RRM1][put-sr][SR][KOG4207][SC35b]
Medicago truncatula@IMGA_AC144459_24_2[2][RRM1:100%][put-sr:100%][KOG4207:100%]Ricinus communis@29581_m000256[RRM1][put-sr][KOG4207]
Arabidopsis thaliana@NP_201225[2][RRM1:100%][put-sr:100%][SR:100%][KOG4207:100%][SC35]Physcomitrella patens@jgi_Phypa1_1_172957[RRM1][put-sr][KOG0415]
Physcomitrella patens@jgi_Phypa1_1_122960[RRM1][put-sr][KOG4207]Zea mays@8925_m000027_AZM5_1178[RRM1][KOG4207]
Oryza sativa_japonica_cultivar-group@NP_001062094[RRM1][put-sr][SR][KOG0415][SC35a]Oryza sativa_japonica_cultivar-group@NP_001050263[RRM1][put-sr][SR][KOG4207][SC35c]
Zea mays@20810_m000015_AZM5_89637[2][RRM1:100%][put-sr:50%][SR:50%][KOG4207:100%][SC35a]Drosophila melanogaster@CG5442-PB[RRM1][put-sr][SR][KOG4207][SC35]
Tribolium castaneum@XP_969931[RRM1][put-sr]Apis mellifera@XP_393352[RRM1][put-sr]Anopheles gambiae@AGAP009742-PA[RRM1][put-sr][KOG4207]
Aedes aegypti@AAEL010340-PB[2][RRM1:100%][put-sr:100%][KOG4207:100%]Strongylocentrotus purpuratus@XP_001180179[4][RRM1:100%*][KOG4207:100%*]
Strongylocentrotus purpuratus@XP_785989[2][RRM1:100%][put-sr:100%][KOG4207:100%]Ciona savignyi@ENSCSAVP00000015651[RRM1][put-sr][KOG4207]
Ciona intestinalis@ENSCINP00000008678[RRM1][put-sr][KOG4207]Oryzias latipes@ENSORLP00000023350[RRM1][put-sr][SR][KOG4368][SC35]
Takifugu rubripes@SINFRUP00000176738[RRM1][put-sr][SR][KOG4207][SC35]Percomorpha@ENSGACP00000004058[2][RRM1:100%][put-sr:100%][SR:100%][SC35]Clupeocephala@ENSDARP00000074623[3][RRM1:100%*][put-sr:100%*][SR:67%][KOG4207:100%*][SC35]
Oryzias latipes@ENSORLP00000001513[RRM1][put sr][SR][KOG4207][SC35] SC35
SC35
"plant"
N1
Fig. S19
153
61
50 51
58
84
70
96
76
97 74
57
66
91
79
58
98 69
100 50
72
52
78
60100
83 92
73
61
64
65
90
67 93
66
62
87
91
75 94
61
55
81 77
60
89
84
87
57
55
Apis mellifera@XP 391860[RRM1][put-sr][KOG0105]Strongylocentrotus purpuratus@XP_001180940[2][RRM1:100%][put-sr:100%][KOG0106:100%]
Danio rerio@ENSDARP00000043311[RRM1][put-sr][KOG0106]Xenopus tropicalis@ENSXETP00000038885[RRM1][put-sr][KOG0106]
Tetraodon nigroviridis@GSTENP00035800001[RRM1][put-sr][KOG0106]Takifugu rubripes@SINFRUP00000169885[RRM1][put-sr][KOG0106]
Gasterosteus aculeatus@ENSGACP00000015556[RRM1][put-sr][KOG0106]Oryzias latipes@ENSORLP00000011623[3][RRM1:100%*][put-sr:67%][SR:33%][KOG0106:100%*]
Gasterosteus aculeatus@ENSGACP00000010395[2][RRM1:100%][put-sr:100%][SR:50%][KOG0106:100%][SRp40]Tetraodontidae@SINFRUP00000132279[2][RRM1:100%][put-sr:50%][SR:50%][KOG0106:100%]
Danio rerio@ENSDARP00000069997[3][RRM1:100%*][put-sr:67%][SR:33%][KOG0106:100%*][SRp40]Ornithorhynchus anatinus@ENSOANP00000021051[RRM1][put-sr][SR][KOG0105][SRp40]
Ornithorhynchus anatinus@ENSOANP00000021053[RRM1][put-sr][SR][KOG0106][SRp40]Ornithorhynchus anatinus@ENSOANP00000021052[RRM1][put-sr][SR][KOG0106][SRp40]
Sorex araneus@ENSSARP00000000971[RRM1][put-sr][SR][KOG0105][SRp40]Amniota@ENSBTAP00000015408[24][RRM1:100%***][put-sr:96%***][SR:100%***][KOG0106:54%**][.KOG0105:46%**][SRp40]Afrotheria@ENSETEP00000016575[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][SRp40]
Catarrhini@ENSP00000342294[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0106:100%*][SRp40]Xenopus tropicalis@ENSXETP00000057107[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][SRp40]
Theria@ENSBTAP00000017699[12][RRM1:100%**][put-sr:100%**][SR:100%**][KOG0106:50%*][.KOG0105:50%*][SRp75]Myotis lucifugus@ENSMLUP00000013443[RRM1][put-sr][SR][KOG0105][SRp75]
Smegmamorpha@ENSGACP00000003112[3][RRM1:100%*][put-sr:100%*][KOG0106:100%*]Tetraodon nigroviridis@GSTENP00010110001[RRM1][put-sr][KOG0598]
Danio rerio@ENSDARP00000094522[RRM1][put-sr]Danio rerio@ENSDARP00000025299[RRM1][put-sr][KOG0105]
Danio rerio@ENSDARP00000095990[2][RRM1:100%][put-sr:100%][SR:50%][KOG0105:100%][SRp55]Oryzias latipes@ENSORLP00000004399[RRM1][put-sr][KOG0105]Tetraodontidae@SINFRUP00000158023[2][RRM1:100%][put-sr:100%][KOG3766:50%][.KOG0105:50%]
Gasterosteus aculeatus@ENSGACP00000008092[3][RRM1:100%*][put-sr:100%*][KOG0105:100%*]Danio rerio@ENSDARP00000022089[RRM1][put-sr][KOG0105]
Xenopus tropicalis@ENSXETP00000054329[RRM1][put-sr][KOG0105]Monodelphis domestica@ENSMODP00000030967[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:50%][.KOG0105:50%][SRp55]Cavia porcellus@ENSCPOP00000010577[RRM1][put-sr][SR][KOG0106][SRp55]Eutheria@ENSDNOP00000006506[3][RRM1:100%*][put-sr:67%][SR:100%*][KOG0105:67%][.KOG0106:33%][SRp55]
Echinops telfairi@ENSETEP00000005046[RRM1][put-sr][SR][KOG0105][SRp55]Murinae@ENSMUSP00000017065[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp55]
Bos taurus@ENSBTAP00000011240[RRM1][put-sr][SR][KOG0105][SRp55]Oryza sativa_japonica_cultivar-group@NP_001052061[RRM1][put-sr][SR][KOG0106][RSp29]
Arabidopsis thaliana@NP_182184[RRM1][put-sr][SR][KOG0106][RSp31a]Arabidopsis thaliana@NP_567120[RRM1][put-sr][SR][KOG0106][RSp31]
Ricinus communis@29742_m001371[RRM1][KOG0106]Physcomitrella patens@jgi_Phypa1_1_167387[RRM1][put-sr][KOG0106]
Oryza sativa_japonica_cultivar-group@NP_001045729[RRM1][put-sr][SR][KOG0106][RSp33]Zea mays@10633_m000022_AZM5_5503[RRM1][KOG0106]
Zea mays@8514_m000507_c0216K08[RRM1][SR][KOG0106][RSp33]Ricinus communis@30147_m014308[RRM1][put-sr][KOG0106]
Medicago truncatula@IMGA_AC152177_25_1[RRM1][put-sr][KOG0106]Arabidopsis thaliana@NP_851174[2][RRM1:100%][put-sr:100%][SR:100%][KOG0106:100%][RSp41]
Arabidopsis thaliana@NP_194280[RRM1][put-sr][SR][KOG0106][RSp40/SRp35]Oryza sativa_japonica_cultivar-group@NP_001055323[RRM1][put-sr][SR][KOG0105][SRp33b]
Oryza sativa_japonica_cultivar-group@NP_001050082[RRM1][put-sr][SR][KOG0105][SRp32]Oryza sativa_japonica_cultivar-group@NP_001060608[RRM1][put-sr][SR][KOG0105][SRp33a]
Physcomitrella patens@jgi_Phypa1_1_140978[RRM1][put-sr][KOG0105]Physcomitrella patens@jgi_Phypa1_1_113630[RRM1][put-sr][KOG0105]
Physcomitrella patens@jgi_Phypa1_1_205547[RRM1][put-sr][KOG0105]Arabidopsis thaliana@NP_190512[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp34a]Ricinus communis@29827_m002610[RRM1][put-sr][KOG0105]Medicago truncatula@IMGA_CT868739_2_1[RRM1][put-sr][SR][KOG0105][SRp34a]
Arabidopsis thaliana@NP_683288[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][SRp30]Medicago truncatula@IMGA_AC144541_27_2[RRM1][put-sr][KOG0105]
Medicago truncatula@IMGA_AC134522_46_2[2][RRM1:100%][put-sr:100%][KOG0105:100%]Ricinus communis@29986_m001610[RRM1][put-sr][SR][KOG0105][SRp33a]
Ricinus communis@30128_m008837[RRM1][put-sr][KOG0105]Ricinus communis@30128_m008840[RRM1][put-sr][KOG0105]
Arabidopsis thaliana@NP_567235[2][RRM1:100%][put-sr:50%][SR:100%][KOG0105:100%][SRp34b]Medicago truncatula@IMGA_AC174141_23_1[RRM1][put-sr][KOG0105]
Arabidopsis thaliana@NP_850933[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0105:100%*][SR1/SRp34]Xenopus tropicalis@ENSXETP00000026703[RRM1][put-sr][SR][KOG0105][SRp30c]
Danio rerio@ENSDARP00000091488[2][RRM1:100%][put-sr:100%][KOG0105:100%]Takifugu rubripes@SINFRUP00000145791[RRM1][put-sr][SR][KOG0105][SRp30c]
Gasterosteus aculeatus@ENSGACP00000022361[2][RRM1:100%][put-sr:100%][KOG0105:100%]Myotis lucifugus@ENSMLUP00000009421[RRM1][put-sr][SR][KOG0105][SRp30c]
Eutheria@ENSCAFP00000015146[7][RRM1:100%*][put-sr:100%*][SR:86%*][KOG0105:100%*][SRp30c]Tupaia belangeri@ENSTBEP00000007356[RRM1][put-sr][SR][KOG0105][SRp30c]
Monodelphis domestica@ENSMODP00000003831[RRM1][put-sr][SR][KOG0105][SRp30c]Mus musculus@ENSMUSP00000031513[RRM1][put-sr][SR][KOG0105][SRp30c]
Bos taurus@ENSBTAP00000016997[RRM1][put-sr][SR][KOG0105][SRp30c]Oryctolagus cuniculus@ENSOCUP00000009368[RRM1][KOG0105]
Diptera@AAEL006473-PA[3][RRM1:100%*][put-sr:100%*][KOG0105:100%*]Tribolium castaneum@XP_967263[RRM1][put-sr][KOG0105]
Nasonia vitripennis@XP_001605411[RRM1][put-sr][KOG0105]Apis mellifera@XP_393525[RRM1][put-sr][KOG0105]
Oryzias latipes@ENSORLP00000006698[RRM1][put-sr][SR][KOG0105][ASF/SF2]Takifugu rubripes@SINFRUP00000151768[RRM1][put-sr][SR][KOG0105][ASF/SF2]
Gasterosteus aculeatus@ENSGACP00000027276[RRM1][put-sr][SR][KOG0105][ASF/SF2]Danio rerio@ENSDARP00000074866[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]
Gasterosteus aculeatus@ENSGACP00000014666[RRM1][SR][KOG0105][ASF/SF2]Tetraodontidae@SINFRUP00000136750[2][RRM1:100%][put-sr:100%][SR:100%][KOG0105:100%][ASF/SF2]Oryzias latipes@ENSORLP00000005758[RRM1][put-sr][SR][KOG0105][ASF/SF2]
Macaca mulatta@ENSMMUP00000004343[RRM1][SR][KOG0105][ASF/SF2]Tetrapoda@ENSBTAP00000019644[17][RRM1:100%**][put-sr:53%**][SR:100%**][KOG0105:100%**][ASF/SF2]
Echinops telfairi@ENSETEP00000004344[RRM1][SR][KOG0105][ASF/SF2]Tupaia belangeri@ENSTBEP00000013333[RRM1][SR][KOG0105][ASF/SF2]
Otolemur garnettii@ENSOGAP00000012982[RRM1][SR][KOG0105][ASF/SF2]
ASF-like
"plant"
SRp30c
ASF/SF2
RS
SRp55
SRp75
SRp40
N5
N6
Fig. S20
154
58 56
100 98
69
69
61 73
58
83
88
73
100
100
63 84
100
96
87
93
98
87 94
82
73
51
58
62
100 72
82 87
53
80
99
70 81
86
94
84 58
64
75
84
97
54
72 86
63 56
91
84
85
99
85
96
95
60 50 88
Clupeocephala@ENSDARP00000074623[3][RRM1:100%*][put-sr:100%*][SR:67%][KOG4207:100%*][SC35]Oryzias latipes@ENSORLP00000001513[RRM1][put-sr][SR][KOG4207][SC35]Percomorpha@ENSGACP00000004058[2][RRM1:100%][put-sr:100%][SR:100%][SC35]Takifugu rubripes@SINFRUP00000176738[RRM1][put-sr][SR][KOG4207][SC35]Oryzias latipes@ENSORLP00000023350[RRM1][put-sr][SR][KOG4368][SC35]Mammalia@ENSBTAP00000024299[19][RRM1:100%**][put-sr:95%**][SR:100%**][KOG4368:74%**][.KOG4207:26%*][SC35]
Dasypus novemcinctus@ENSDNOP00000000330[RRM1][put-sr][SR][KOG4368][SC35]Erinaceus europaeus@ENSEEUP00000008808[RRM1][put-sr][SR][SC35]
Homo sapiens@ENSP00000350877[RRM1][KOG4207]Pan troglodytes@ENSPTRP00000032751[RRM1][KOG4207]
Macaca mulatta@ENSMMUP00000034012[RRM1][SR][KOG4207][SC35]Ciona savignyi@ENSCSAVP00000008618[RRM1][put-sr][KOG0111]
Gasterosteus aculeatus@ENSGACP00000018038[RRM1][put-sr]Danio rerio@ENSDARP00000091866[RRM1][put-sr]
Danio rerio@ENSDARP00000031512[RRM1][put-sr][KOG0415]Gasterosteus aculeatus@ENSGACP00000002897[RRM1][put-sr][KOG0415]
Tetraodon nigroviridis@GSTENP00010468001[RRM1][SRrp][KOG4207][SRp38]Takifugu rubripes@SINFRUP00000150947[RRM1][put-sr]Oryzias latipes@ENSORLP00000009635[RRM1][SRrp][KOG4207][SRp38]
Echinops telfairi@ENSETEP00000001114[RRM1][put-sr]Mus musculus@ENSMUSP00000103794[RRM1][put-sr][SRrp][KOG0111][SRrp35]
Catarrhini@ENSP00000358479[3][RRM1:100%*][put-sr:100%*][SRrp:100%*][SRrp35]Erinaceus europaeus@ENSEEUP00000010036[RRM1][put-sr][SRrp][SRrp35]
Monodelphis domestica@ENSMODP00000022797[RRM1][put-sr][SRrp][SRrp35]Cavia porcellus@ENSCPOP00000009809[RRM1][put-sr][SRrp][SRrp35]
Canis familiaris@ENSCAFP00000004604[RRM1][put-sr][SRrp][SRp38]Eutheria@ENSBTAP00000010616[19][RRM1:100%**][put-sr:100%**][SRrp:100%**][KOG0111:58%**][.KOG0415:21%*][SRp38]Canis familiaris@ENSCAFP00000019234[RRM1][put-sr][SRrp][SRp38]
Eutheria@ENSEEUP00000013029[3][RRM1:100%*][put-sr:100%*][SRrp:100%*][SRp38]Monodelphis domestica@ENSMODP00000016281[RRM1][put-sr][SRrp][SRp38]Rattus norvegicus@ENSRNOP00000011154[2][RRM1:100%][put-sr:100%][SRrp:100%][SRp38]
Xenopus tropicalis@ENSXETP00000011851[RRM1][put-sr]Gallus gallus@ENSGALP00000006566[RRM1][put-sr][SRrp][SRp38]
Volvox carteri@jgi_Volca1_73973[RRM1][put-sr][KOG4207]Chlamydomonas reinhardtii@jgi_Chlre3_113900[RRM1][KOG4207]
Volvox carteri@jgi_Volca1_120666[RRM1][put-sr]Chlamydomonas reinhardtii@jgi_Chlre3_188086[RRM1][put-sr]
Volvox carteri@jgi_Volca1_121229[RRM1][put-sr][KOG0415]Chlamydomonas reinhardtii@jgi_Chlre3_116256[RRM1][put-sr]
Arabidopsis thaliana@NP_187966[RRM1][put-sr][SR][SCL30a]Arabidopsis thaliana@NP_001031195[2][RRM1:100%][put-sr:100%][SR:100%][KOG0110:100%][SR33/SCL33]
Ricinus communis@30084_m000177[RRM1][put-sr]Ricinus communis@27553_m000316[RRM1][put-sr]
Medicago truncatula@IMGA_AC146760_9_2[RRM1][put-sr]Oryza sativa_japonica_cultivar-group@NP_001060372[RRM1][put-sr][SR][SCL25]
Oryza sativa_japonica_cultivar-group@NP_001050213[RRM1][put-sr][KOG4207]Physcomitrella patens@jgi_Phypa1_1_108464[RRM1][put-sr]
Physcomitrella patens@jgi_Phypa1_1_141868[RRM1]Oryza sativa_japonica_cultivar-group@NP_001050168[RRM1][put-sr]
Ricinus communis@29726_m003960[RRM1][put-sr]Arabidopsis thaliana@NP_197382[RRM1][put-sr][SR][KOG0127][SCL28]
Oryza sativa_japonica_cultivar-group@NP_001068546[RRM1][put-sr][KOG0127]Oryza sativa_japonica_cultivar-group@NP_001046448[RRM1][put-sr][SR][SCL30a]
Oryza sativa_japonica_cultivar-group@NP_001067091[RRM1][put-sr][SR][SCL30b]Ricinus communis@27383_m000159[RRM1][put-sr][KOG0127]
Medicago truncatula@IMGA_CR962128_15_2[RRM1][put-sr]Arabidopsis thaliana@NP_567021[RRM1][put-sr][SR][KOG0122][SCL30]
Chlamydomonas reinhardtii@jgi_Chlre3_132362[RRM1][KOG0107]Volvox carteri@jgi_Volca1_121301[RRM1][put-sr][KOG0107]
Chlamydomonas reinhardtii@jgi_Chlre3_192053[RRM1][put-sr][KOG0107]Ricinus communis@28610_m000073[RRM1][SR][KOG0107][SRZ21/RSZ21]
Physcomitrella patens@jgi_Phypa1_1_143810[2][RRM1:100%][KOG0107:100%]Oryza sativa_japonica_cultivar-group@NP_001048352[RRM1][put-sr][SR][RSZp21b]
Oryza sativa_japonica_cultivar-group@NP_001057018[RRM1][put-sr][SR][RSZp21a]Oryza sativa_japonica_cultivar-group@NP_001047400[RRM1][put-sr][SR][KOG0107][RSZp23]
Ricinus communis@29848_m004475[RRM1][put-sr][SR][SRZ22/RSZ22]Medicago truncatula@IMGA_CR936368_17_2[RRM1][put-sr][KOG0107]
Arabidopsis thaliana@NP_180035[RRM1][put-sr][SR][RSZ22a]Arabidopsis thaliana@NP_973901[2][RRM1:100%][SR:100%][SRZ21/RSZ21]
Arabidopsis thaliana@NP_194886[2][RRM1:100%][put-sr:100%][SR:100%][KOG0107:100%][SRZ22/RSZ22]Apis mellifera@XP_001123058[2][RRM1:100%][put-sr:50%][KOG0107:100%]Endopterygota@XP_001599712[6][RRM1:100%*][put-sr:17%][KOG0107:83%*][.KOG2490:17%]
Culicidae@AAEL001356-PA[3][RRM1:100%*][put-sr:100%*][KOG0108:67%][.KOG0107:33%]Drosophila melanogaster@CG17136-PD[4][RRM1:100%*][put-sr:50%][KOG0107:100%*]
Drosophila melanogaster@CG1987-PA[RRM1][put-sr][KOG0107]Percomorpha@ENSGACP00000016280[4][RRM1:100%*][put-sr:100%*][KOG0107:50%][.KOG4368:25%]
Oryzias latipes@ENSORLP00000000921[3][RRM1:100%*][put-sr:100%*][KOG4368:33%][.KOG0107:33%]Danio rerio@ENSDARP00000051184[2][RRM1:100%][put-sr:100%]
Gallus gallus@ENSGALP00000022386[RRM1][put-sr][SR][9G8]Spermophilus tridecemlineatus@ENSSTOP00000003936[RRM1][put-sr]
Xenopus tropicalis@ENSXETP00000054077[2][RRM1:100%][put-sr:100%][SR:100%][9G8]Mammalia@ENSBTAP00000033048[27][RRM1:100%***][put-sr:78%***][SR:93%***][KOG0107:81%***][9G8]
Monodelphis domestica@ENSMODP00000010787[RRM1][put-sr][SR][KOG0107][9G8]Rattus norvegicus@ENSRNOP00000040587[RRM1][put-sr][SR][KOG0107][9G8]
Canis familiaris@ENSCAFP00000009434[RRM1][put-sr][KOG0107]Danio rerio@ENSDARP00000070952[RRM1][SR][KOG0107][9G8]
Gallus gallus@ENSGALP00000038155[RRM1][put-sr][SR][9G8]Rattus norvegicus@ENSRNOP00000011102[RRM1][put-sr][SR][KOG0107][9G8]
Rattus norvegicus@ENSRNOP00000058047[RRM1][put-sr]Tribolium castaneum@XP_968789[RRM1][put-sr][KOG4368]
Apis mellifera@XP_001122800[RRM1][put-sr][KOG0107]Drosophila melanogaster@CG10203-PA[RRM1][put-sr][SR][KOG0107][9G8]
Anopheles gambiae@AGAP008303-PA[RRM1][put-sr]Ciona savignyi@ENSCSAVP00000004510[RRM1][put-sr]Ciona intestinalis@ENSCINP00000022204[2][RRM1:100%][put-sr:100%][KOG0107:100%]
Mus musculus@ENSMUSP00000100538[RRM1][put-sr][SR][KOG0107][SRp20]Tetrapoda@ENSBTAP00000004154[28][RRM1:100%***][put-sr:68%**][SR:100%***][KOG0107:100%***][SRp20]Eutheria@ENSEEUP00000001001[3][RRM1:100%*][put-sr:100%*]
Gasterosteus aculeatus@ENSGACP00000001909[3][RRM1:100%*][put-sr:100%*][SR:100%*][KOG0107:100%*][SRp20]Takifugu rubripes@SINFRUP00000147448[RRM1][put-sr][SR][KOG0107][SRp20]
Oryzias latipes@ENSORLP00000024888[RRM1][put-sr][SR][KOG0107][SRp20]Danio rerio@ENSDARP00000035207[2][RRM1:100%][put-sr:50%][SR:100%][KOG0107:100%][SRp20]
Oryzias latipes@ENSORLP00000000358[RRM1][put-sr][SR][KOG0107][SRp20]Tetraodon nigroviridis@GSTENP00027331001[RRM1][SR][KOG0107][SRp20]
Takifugu rubripes@SINFRUP00000136850[RRM1][SR][KOG0107][SRp20]Gasterosteus aculeatus@ENSGACP00000001355[RRM1][put-sr][SR][KOG0107][SRp20]Danio rerio@ENSDARP00000076899[2][RRM1:100%][put-sr:50%][SR:100%][KOG0107:100%][SRp20]
Ricinus communis@29805_m001527[RRM1][put-sr][KOG0109]Oryza sativa_japonica_cultivar-group@NP_001054731[RRM1][put-sr][SR][RSZ39]
Oryza sativa_japonica_cultivar-group@NP_001054489[RRM1][put-sr][SR][KOG0109][RSZ36]Oryza sativa_japonica_cultivar-group@NP_001049771[RRM1][put-sr][SR][KOG0109][RSZ37b]
Oryza sativa_japonica_cultivar-group@NP_001042066[RRM1][put-sr][SR][KOG0109][RSZ37a]Arabidopsis thaliana@NP_190918[RRM1][put-sr][SR][KOG0107][RSZ32]
Arabidopsis thaliana@NP_850280[RRM1][put-sr][SR][KOG0107][RSZ33]Tribolium castaneum@XP_969451[RRM1][put-sr][KOG0105]
Nasonia vitripennis@XP_001603815[2][RRM1:100%][put-sr:100%][KOG0105:100%]Aedes aegypti@AAEL000769-PA[RRM1][put-sr][KOG0106]
Diptera@AGAP004592-PA[7][RRM1:100%*][put-sr:71%*][SR:86%*][KOG0105:57%*][.KOG0106:43%*]Tribolium castaneum@XP_966697[RRM1][put-sr][KOG0106]
Apis mellifera@XP_391860[RRM1][put sr][KOG0105]
RS2Z "plant"
SRp20
9G8
RSZ
"plant"
SRrp
SCL
SC35
N1
N2
N3
N4
Fig. S20
155
0.11 69
98
91 99
56
70 70
99
65
54
55
85
63 71
50
58
56
68
93
99
100
83 99
99
99
78 79
60 72
100
70
65
52
82
77
99
56
73
96
53 52
90 52
86
77
100
97
98
69
55
96
83
Thalassiosira pseudonana@jgi_Thaps3_19374[RRM1][KOG0121]Phaeodactylum tricornutum@jgi_Phatr2_13520[RRM1][KOG0121]
Volvox carteri@jgi_Volca1_79141[RRM1][KOG0121]Chlamydomonas reinhardtii@jgi_Chlre3_169371[RRM1][KOG0121]
Cyanidioschyzon merolae@gnl_CMER_CMQ282C[RRM1][KOG0121]Oryza sativa_japonica_cultivar-group@NP_001047412[RRM1][KOG0121]
Ricinus communis@29983_m003140[RRM1][KOG0121]Arabidopsis thaliana@NP_199233[2][RRM1:100%][KOG0121:100%]
Anopheles gambiae@AGAP002547-PA[RRM1][KOG0121]Drosophila melanogaster@CG12357-PA[RRM1][KOG0121]
Aedes aegypti@AAEL006135-PA[RRM1][KOG0121]Dictyostelium discoideum_AX4@XP_637361[RRM1][KOG0121]
Schizosaccharomyces pombe_972h-@NP_596414[RRM1][KOG0121]Gibberella zeae_PH-1@XP_385664[RRM1][KOG0121]
Aspergillus fumigatus_Af293@XP_755191[RRM1][KOG0121]Strongylocentrotus purpuratus@XP_001187788[2][RRM1:100%][KOG0121:100%]
Nasonia vitripennis@XP_001600470[RRM1][KOG0121]Nasonia vitripennis@XP_001608109[RRM1][KOG0121]
Apis mellifera@XP_397316[RRM1][KOG0121]Tribolium castaneum@XP_975066[RRM1][KOG0121]
Ciona savignyi@ENSCSAVP00000009906[RRM1][KOG0121]Ciona intestinalis@ENSCINP00000006257[2][RRM1:100%][KOG0121:100%]
Eutheria@ENSBTAP00000011684[11][RRM1:100%**][KOG0121:100%**]Sorex araneus@ENSSARP00000012929[RRM1][KOG0121]
Loxodonta africana@ENSLAFP00000005354[RRM1][KOG0121]Cavia porcellus@ENSCPOP00000002703[RRM1][KOG0121]
Spermophilus tridecemlineatus@ENSSTOP00000001416[RRM1][KOG0121]Oryctolagus cuniculus@ENSOCUP00000012352[RRM1][KOG0121]
Monodelphis domestica@ENSMODP00000019849[RRM1][KOG0121]Monodelphis domestica@ENSMODP00000034858[2][RRM1:100%][KOG0121:100%]
Monodelphis domestica@ENSMODP00000029243[RRM1][KOG0121]Gallus gallus@ENSGALP00000011061[RRM1][KOG0121]
Xenopus tropicalis@ENSXETP00000041997[RRM1][KOG0121]Oryzias latipes@ENSORLP00000014087[RRM1][KOG0121]Danio rerio@ENSDARP00000020688[RRM1][KOG0121]
Takifugu rubripes@SINFRUP00000128783[RRM1][KOG0121]Tetraodon nigroviridis@GSTENP00011485001[RRM1][KOG0121]
Gasterosteus aculeatus@ENSGACP00000008263[RRM1][KOG0121]Volvox carteri@jgi_Volca1_103546[RRM1][KOG0116]
Chlamydomonas reinhardtii@jgi_Chlre3_184151[RRM1][KOG0921]Schizosaccharomyces pombe_972h-@NP_595727[RRM1][KOG0122]
Ustilago maydis_521@XP_760099[RRM1][KOG0122]Aspergillus fumigatus_Af293@XP_755320[RRM1][KOG0122]
Neurospora crassa_OR74A@XP_962716[RRM1][KOG0122]Gibberella zeae_PH-1@XP_385241[RRM1][KOG0122]
Physcomitrella patens@jgi_Phypa1_1_164814[RRM1][KOG0122]Physcomitrella patens@jgi_Phypa1_1_196691[RRM1][KOG0122]
Ostreococcus tauri@jgi_Ostta4_5527[RRM1][KOG0122]Ostreococcus lucimarinus@jgi_Ost9901_3_6420[RRM1][KOG0122]
Chlamydomonas reinhardtii@jgi_Chlre3_112621[RRM1][KOG0122]Oryza sativa_japonica_cultivar-group@NP_001048346[RRM1][KOG0122]
Oryza sativa_japonica_cultivar-group@NP_001048347[RRM1][KOG0122]Medicago truncatula@IMGA_AC174277_12_1[2][RRM1:100%][KOG0122:100%]
Arabidopsis thaliana@NP_187747[RRM1][TIF3][KOG0122][TIF3]Arabidopsis thaliana@NP_196219[RRM1][TIF3][KOG0122][TIF3]
Phytophthora ramorum@jgi_Phyra1_1_79758[RRM1][KOG0122]Phytophthora sojae@jgi_Physo1_1_108333[RRM1][KOG0122]
Phaeodactylum tricornutum@jgi_Phatr2_16281[RRM1][KOG0122]Thalassiosira pseudonana@jgi_Thaps3_32790[RRM1][KOG0122]
Aureococcus anophagefferens@jgi_Auran1_9314[2][RRM1:100%][KOG0585:50%][.KOG0122:50%]Strongylocentrotus purpuratus@XP_791582[2][RRM1:100%][KOG0122:100%]
Ciona intestinalis@ENSCINP00000000359[RRM1][KOG0122]Tetraodon nigroviridis@GSTENP00034383001[RRM1][KOG0122]Takifugu rubripes@SINFRUP00000147763[RRM1][KOG0122]
Gasterosteus aculeatus@ENSGACP00000018150[RRM1][KOG0122]Tetrapoda@ENSBTAP00000003545[10][RRM1:100%**][KOG0122:100%**]Clupeocephala@ENSDARP00000027672[2][RRM1:100%][KOG0122:100%]
Cyanidioschyzon merolae@gnl_CMER_CML202C[RRM1][put-sr]Oryza sativa_japonica_cultivar-group@NP_001050263[RRM1][put-sr][SR][KOG4207][SC35c]
Zea mays@20810_m000015_AZM5_89637[2][RRM1:100%][put-sr:50%][SR:50%][KOG4207:100%][SC35a]Zea mays@8925_m000027_AZM5_1178[RRM1][KOG4207]
Oryza sativa_japonica_cultivar-group@NP_001062094[RRM1][put-sr][SR][KOG0415][SC35a]Physcomitrella patens@jgi_Phypa1_1_172957[RRM1][put-sr][KOG0415]
Physcomitrella patens@jgi_Phypa1_1_122960[RRM1][put-sr][KOG4207]Oryza sativa_japonica_cultivar-group@NP_001060322[RRM1][put-sr][SR][KOG4207][SC35b]
Medicago truncatula@IMGA_AC144459_24_2[2][RRM1:100%][put-sr:100%][KOG4207:100%]Ricinus communis@29581_m000256[RRM1][put-sr][KOG4207]
Arabidopsis thaliana@NP_201225[2][RRM1:100%][put-sr:100%][SR:100%][KOG4207:100%][SC35]Drosophila melanogaster@CG5442-PB[RRM1][put-sr][SR][KOG4207][SC35]
Tribolium castaneum@XP_969931[RRM1][put-sr]Apis mellifera@XP_393352[RRM1][put-sr]Anopheles gambiae@AGAP009742-PA[RRM1][put-sr][KOG4207]
Aedes aegypti@AAEL010340-PB[2][RRM1:100%][put-sr:100%][KOG4207:100%]Strongylocentrotus purpuratus@XP_001180179[4][RRM1:100%*][KOG4207:100%*]
Strongylocentrotus purpuratus@XP_785989[2][RRM1:100%][put-sr:100%][KOG4207:100%]Ciona savignyi@ENSCSAVP00000015651[RRM1][put-sr][KOG4207]
Ciona intestinalis@ENSCINP00000008678[RRM1][put-sr][KOG4207]Danio rerio@ENSDARP00000015569[RRM1][put-sr][SR][KOG4207][SC35]
Xenopus tropicalis@ENSXETP00000054042[RRM1][put-sr][SR][SC35]Macaca mulatta@ENSMMUP00000010035[RRM1][put-sr][SR][SRp46]
Homo sapiens@ENSP00000381889[RRM1][put-sr][KOG4207]Clupeocephala@ENSDARP00000074623[3][RRM1:100% ][put sr:100% ][SR:67%][KOG4207:100% ][SC35]
SC35
SC35
"plant"
Fig. S20
156
0
1
2
3
4
bit
s
1
L2
LK
3
V4
LD
5
N6
VIL
7
ST
8
T
FY
9
G
SR
10
T11
A
TS
12AP
13
ED
14
S
C
DT
15
L16
S
L
KYFR
17
Y
A
PR
18
S
A
CLV
19
F20
ADE
21
RK
22
CY
23
G
24
DKER
25
V
26
LVG
27
D
28
IV
29
R
FY
30
I
31
P
32
R
33
ED
34
PHKR
35
HFRY
36
ST
37
GRK
38
ADE
39
PS
40
R
41
G
42
S
F
43
A
44
F
45 46
V
47
R
48
YF
49
N
L
F
PYKH
50
YD
51
REAK
52
S
E
DR
53
ED
54
A
55
SH
QE
56
KD
57
A
58
EL
IVM
59
N
AED
60
G
SRA
61
LM
62
D
63
W
A
G
64
M
KNRA
65
W
R
D
T
E
MLV
66
M
FPYVL
67
GD
68
V
A
C
G
69
P
L
G
R
70
V
NAKE
71
V
AI
L
72
P
VDTMR
73
Q
G
LV
0
1
2
3
4
bit
s
1
L
2
FL
3
IFV
4
SR
5
N
6
IL
7
SRP
8
KRHL
9
TSD
10
TAC
11
STR
12
GTQAP
13
NDE
14
ED
15
VI
L16
QR
17
K
H
G
A
VI
R
18
YTSP
19
TAF
20
QGE
21HKQR
22YF
23
G24
ARVP
25
ILV
26
RK
27
D28
VI
29
Y30
IL
31
P
32
KR
33
ND
34
FY
35
QNHY
36
ST
37
RG
38
L
QDE
39
LP
40
R
41
G
42
LF
43
AG
44
F
45 46
IV
47
KEQ
48
YF
49
YSLARMV
50
HEYD
51
TSAP
52
S
Q
D
RKEYA
53
ED
54
A
55
MGESA
56
VKDE
57
A
58
MRQK
59
RKQHY
60
Y
Q
E
SRCH
61
LM
62
ND
63
RHG
64
E
SRYKQ
65
S
M
TL
IV
66
VF
IL
67
S
Q
FGAL
68
G
69
R
70
VE
71
VL
I
72
RAST
73
IV
RRM1 SC35
RRM1 SCL
RRM1 SRrp
63 domains
21 domains
41 domains
A. RRM1 of Single RRM SR proteins
�1 �2 �3 �4�1 �2L1 L2 L3 L4 L5
0
1
2
3
4
bit
s
1
L
2
F
3
IV
4
R
5
N
6
SIV
7
TG
SA
8
D
9
V
NEAD
10
IST
11
R
12
PS
13
E
14
D
15
L
16
PR
17
R
18
E
19
F
20
V
G
21
R22
FY
23
G24
SP
25
VI
26
SV
27
D28
V29
Y30
IV
31P
32VL
33
D34
YF
35
Y36
ST
37
R38
HQR
39
SP
40
R41
G
42
F
43
A
44
Y
45
FL
46
S
FIV
47
ETI
Q
48
YIF
49
V
PD
QE
50
D
51
V
52
R
53
D
54
A
55
E
56
D
57
A
58
L
59
YH
60
ASN
61
ML
62
ND
63
KR
64
NK
65
W
66
VI
67
C
68
G
69
R
70
Y
Q
71
I
72
E
73
VI
RNP2 RNP1
Fig. S21
157
0
1
2
3
4
bit
s
1
LIV
2
Y
3
IV
4
G
5
N
6
L
7
PD
8
SAP
9
GDR
10
AIV
11
RSAT
12
SAE
13
GER
14
DE
15
IVL
16
RE
17
TD
18
DE
19
F
20
VHKER
21
SMRAV
22
YF
23
G24
RV
25
IVL
26
R27
TNS
28
IV
29W
30
V31
GA
32
R33
RK
34
P35
P36
G
37
YF
38
A
39
F
40
VML
I
41
ED
42
MF
43
ED
44
D
45
S
L
PKEDR
46
R
47
D
48
A
49
RLED
50
D
51
A
52
LVI
53
HSR
54
KEDA
55
VIL
56
ND
57
RG
58
MFK
59
KQN
60 61 62
G
63
W
64
R
65
V
66
E
67
IFL
0
1
2
3
4
bit
s
1
V2
Y3
V4
G5
DN
6
L7
E
G8
NT
9
G10
VA
11S
AG
12
RK
13
R
G14
E15
L16
KE
17
R18
SA
19
LF
20
G
S
21
Y
22
Y
23
G
24
SP
25
L
26
R
27
ST
28
V
29
W
30
VI
31
VA
32
KR
33
N
34
P
35
AP
36
G
37
F
38
PA
39
F
40
V
41
E
42
YF
43
E
44
D
45
TAP
46
TR
47
HD
48
A
49
KE
50
PD
51
V
SLA
52
LV
53
L
G
QKR
54
S
RD
G
55
S
ML
56
KG
D
57
S
G
58
RK
59
I
LV
60
LI
61
C
62
G
63
A
S
64
GR
65
MV
66
R
67
V
0
1
2
3
4
bit
s
1
L
2
Y
3
V
4
G
5
HR
6
IL
7
AS
8
LS
9
R
10
T
11
R
12
ATS
13
ER
14
D
15
L
16
E
17
N
DRY
18
HL
19
F
20
GS
21
KR
22
Y
23
G
24
R
25
IV
26
R
27
Y
FED
28
V
29
ED
30
LM
31
K
32 33 34 35
NHR
36
ED
37
FY
38
GA
39
F40
IV
41
E42
F43
GS
44
D45
AP
46
R
47
D
48
A
49
NED
50
ED
51
A
52
R
53
LHY
54
H
DYN
55
L
56
D
57
G
58
KR
59
KD
60
Y
LVF
61
D
62
G
63
S
64
DR
65
MI
66
TL
I
67
V
0
1
2
3
4
bit
s
1
V
2
Y
3
V
4
G
5
N
6
L
7
G
8
SN
9
SN
10
G11
N12
K13
ST
14
DE
15
L16
E17
W
SR
18
SA
19
F20
G21
Y22
Y23
G24
P25
L26
R27
T
S28
V29
W
30
V
31
A
32
R
33
N
34
P
35
P
36
G
37
F
38
A
39
F
40
V
41
E
42
F
43
E
44
D
45
SP
46
R
47
D
48
A
49
SNTA
50
D
51
A
52
V
53
KR
54
E
55
L
56
D
57
G
58
R
59
HT
60
ML
61
C
62
G
63
C
64
R
65
V
66
R
67
V
RRM1 9G8
RRM1 SRp20
RRM1 RS2Z
RRM1 RSZ
47 domains
45 domains
16 domains
7 domains
B. RRM1 of Single RRM ZnK-like SR proteins
L5L4L3L2L1�2�1 �4�3�2�1
RNP2 RNP1
Fig. S21
158
0
1
2
3
4
bit
s
1
IV
2
YF
3
VI
4
G
5
HKR
6
L
7
NS
8
YP
9
SRNHQA
10
VA
11
R
12
E
13
RK
14
D
15
IV
16
QE
17
KR
18
F
19
F
20
R
GSK
21
G22
FY
23
G24
KR
25
LI
26
K
MLR
27
DE
28
VI
29
ND
30M
L31
K32 33 34 35 36 37
K
RN
38
G39
YF
40
G
41
F
42
V
43
E
44
F
45
DE
46
D
47
Y
T
NHSLP
48
R
49
D
50
A
51
ED
52
D
53
V
A
54
Y
V
55
E
Y
56
DE
57
L
58
DN
59
S
G
60
K
61
DE
62
L
63
VL
C
64 65 66
NGS
67
KE
68
R
69
Y
V
70
M
IT
71
VI
0
1
2
3
4
bit
s
1
V
I2
Y3
V4
E
G5
N6
L7
Q
P8
VSAMTP
9
D10
VI
11G
QR
12SET
13
RK
14
ED
15
VL
I
16
K
QE
17
V
D18
M
VL
19
F20
D
FHY
21
R
K
22
FY
23
G
24
TKRA
25
VI
26
S
I
TR
27
T
FED
28
VI
29
ED
30
L
31
K
32
N
33
Q
L
NR
34
S
HR
35
W
SG
36
A
TLG
37
R
AI
VP
38
L
P
39
F
40
A
41
F
42
IV
43
S
QRE
44
F
45
Q
N
DE
46
S
N
E
D
47
L
AP
48
R
49
D
50
SA
51
H
G
DE
52
N
D
53
V
A
54
IV
55
KFHY
56
E
AG
57
R
58
ND
59
G
60
Y
61
V
E
GD
62
FY
63
Y
E
GD
64 65 66
S
DQG
67
SCY
68
KR
69
L
70
R
71
V
0
1
2
3
4
bit
s
1
IV
2
YF
3
VC
4
G
5
N
6
LF
7
DE
8
FY
9
ED
10
CVTA
11
R
12
IHEQ
13
GS
14
DE
15
VIL
16
DE
17
R
18
L
19
F
20
Y
KD
GSR
21
ERK
22
FY
23
G
24
KR
25
IV
26
KDE
27
R
28
IV
29
D
30
LM
31
K
32 33 34 35 36 37
TAS
38
G39
YF
40SA
41F
42
IV
43
Y44
FM
45
E46
D47
E48
R
49
D
50
GA
51
ADE
52
AED
53
A
54
I
55
HSR
56
KHGRA
57
TL
58
D
59
GNR
60
YTMF
I
61
TSPDE
62
YF
63
G
64
PYR
65
QE
DTGK
66
KRG
67
R
68
KR
69
IL
70
KSR
71
V
0
1
2
3
4
bit
s
1
VL
I
2
Y
3
V
4
G
5
N
6
L
7
P
8
SAG
9
D
10
VI
11
R12
WQKLE
13
WSHCR
14
E15
IV
16
KE
17
HD
18
IL
19
F20
MSY
21K
22FY
23
G24
LHRP
25
VI
26
TMLAV
27
HREQD
28
VI
29
ED
30
L
31
RK
32
NLVI
33
P
34
P
35
KR
36
TP
37
P
38
CG
39
FY
40
CA
41
F
42
LI
V
43
VQE
44
F
45
KDE
46
ENHD
47
TGSPA
48
LCR
49
ND
50
A
51
QDE
52
ED
53
A
54
CI
55
C
A
KHYR
56
EYG
57
CR
58
HD
59
G
60
Y
61
KND
62
LF
63
ND
64 65 66
G
67
F
YNHC
68
QHR
69
L
70
LR
71
V
RRM1 ASF-like (animals)
RRM1 ASF-like (plants)
RRM1 RS
RRM1 SRp40-55-75
55 domains
24 domains
91 domains
13 domains
C. RRM1 of Dual RRM SR proteins
L5L4L3L2L1�2�1 �4�3�2�1
RNP2 RNP1
Fig. S21
159
0
1
2
3
4
bit
s
1
L
2
VH
3
IV
4
GD
5
NHCS
6
L7
TS
8
R9
N10
V11
TN
12E
13
TGDA
14
H15
IL
16
RK
17
E18
I
19
F
20
ESG
21
LCN
22
YF
23
G
24
VE
25
LIV
26
KIV
27
SNH
28
V
29
E
30
IL
31
SA
32
M
33
D
34
R
35 36
V
S
M
TA
37
V
38
N
39
L
40
P
41
KR
42
G
43
FHY
44
AG
45
HY
46
IV
47
E
48
YF
49
EK
50 51
HR
52
V
G
E
TA
53
D
54
A
55
E
56
RK
57
A
58
QL
59
DAL
60
FHY
61
LM
62
ND
63
NG
64
AG
65
Q
66
I
67
D
68
G
69
KN
70
IAV
71
V
72
SRK
73
LVA
0
1
2
3
4
bit
s
1
CL
IV
2
TYH
3
VL
I
4
KE
A
G
5
KHGR
6
SL
7
PST
8
PK
GR
9
T
QK
IN
10
TI
V
11
NIT
12
ERK
13
ED
14
H15
VL
I16
V
R
L
H
F
T
QM
17
E18
I19
F20
TA
G
S21
H
SIT
22FY
23
R
G24
R
Q
P
N
D
EAK
25
L
VI
26
TS
RK
27
N
H
KASM
28
VI
29
ED
30
L
IFM
31
RA
P
32
S
R
K
I
A
PMV
33
NDE
34
HKR
35
Y
A
FIVLM
36
R
Q
N
L
FYH
37
QG
AP
38
R
PA
NH
39
V
P
H
QMFL
40
T
CGS
41
Q
RK
42
C
G
43
V
S
H
FY
44
VCA
45
FY
46
IV
47
DE
48
YF
49
V
TS
A
ME
50
R
D
A
STN
51
SHAP
52
GNED
53
G
DE
54
CA
55
DAQE
56
SNK
57
TA
58
I
VML
59
K
60
YH
61
M
62
ND
63
G
64
G
65
Q
66
I
67
D
68
G
69
K
Q
70
QL
E
71
I
72
SR
MT
73
VA
RRM1 SR45
RRM1 RNPS1
8 domains
43 domains
D. RRM1 of RNPS1-like proteins
L5L4L3L2L1�2�1 �4�3�2�1
RNP2 RNP1
Fig. S21
160
�2
0
1
2
3
4
bit
s
1
MI
L
2
FLY
3
IV
4
SARG
5
GN
6
V
M
IL
7 8
T
DANSP
9
RY
10
ADSKNR
11
M
LTAV
12
R
SKTHN
13
TQNDE
14
T
QDESAG
15
TAQHED
16
MIVL
17
T
L
E
A
QGKR
18
N
S
DVQAE
19
M
H
FAVL
20
LMF
21
Q
RSGAE
22
V
P
K
DAQE
23
R
QHFY
24
W
G
25
V
KQTPE
26
F
LIV
27
N
28
T
RN
L
GAS
29
ACV
30
V
N
STKR
31
VI
L
32
P
MIV
33
V
E
ILTMRK
34
V
R
N
G
E
QD
35
P
QKR
36
Y
H
D
ARKE
37
ST
38
QN
RG
39
L
EQKR
40
TP
RS
41
RK
42
K
G43
YF
44
AG
45
F46
AIV
47K
IDVE
48
ILM
49
I
G
D
SEAP
50
A
KTEDNS
51
P
V
SKADE
52
R
N
GDSEA
53
Q
AGDE
54
V
L
E
GA
55
S
N
IAEDKQ
56
V
P
T
ENAK
57
VA
58
LM
I
59
SNEDVAK
60
Q
N
SD
KEA
61
M
E
AL
62
HDN
63
T
QEDG
64
V
Q
S
YTFAK
65
V
R
T
P
DSKNE
66
I
LVYF
67
V
L
K
GDMAEQ
68
D
A
TKQEG
69
QNSKR
70
V
S
R
G
QNPKT
71
V
MI
L
72
S
A
VRK
73
LIV
0
1
2
3
4
bit
s
1
VI
L
2
Y
3
VI
4
G
5
N
6
L
7
P
8
KP
9
REQ
10
S
DVNGET
11
M
LVI
F
12
T
S
K
DNE
13
V
SEQPR
14
EAQK
15
DAE
16
FL
17
V
AQDE
18
N
G
E
D
SKTA
19
M
F
IQVL
20
IFL
21
S
R
Q
N
TKA
22
Q
PG
AES
23
EI
AV
24
TNSG
25
KAED
26
AVSG
27GVI
28KTSR
29
LATF
30
K31
T
SVLA
32
IV
33
RKFTL
34
D35
KR
36
R
DKE
37
T
38
KG
39
V
S
GEAK
40
SC
41
R
42
G
43
F
44
AG
45
F
46
LVA
47
NT
48
S
LA
ITV
49
E
AKSDN
50
STND
51
PDE
52
QNDKE
53
M
IALQNV
54
TSA
55
EQND
56
S
EQLA
57
YF
ILV
58
I
59
QE
60
ARQK
61
YFL
62
N
63
N
G
64
TH
YRQKF
65
T
Q
MSDE
66
YVF
67
R
M
QKGN
68
EDG
69
VTNS
70
S
Q
ATPNK
71
IL
72
KR
73
LIV
0
1
2
3
4
bit
s
1
V
M
LI
2
S
LFY
3
IV
4
A
RG
5
G
SN
6
M
I
L7
P8
V
D
NASP
9
E
RWQFY
10
G
A
K
N
TQ
EDSR
11
M
ILFTAV
12
D
K
HRSNET
13
A
P
SRDQE
14
S
KQGADE
15
T
SHAQED
16
FIVL
17
I
T
EQKR
18
T
K
S
DQAE
19
T
F
S
Q
I
AVL
20
MLF
21
KTGESA
22
D
PASQE
23
A
VHFY
24
S
G
25
DSQPKATE
26
SGIV
27
E
I
T
K
28
A
T
K
ENRS
29
I
T
FCAV
30
A
T
H
NQSRK
31
AVI
L
32
MVP
I
33
V
I
RKMLT
34
ED
35
P
QKR
36
L
RFKDE
37
ST
38
RKG
39
AEQKR
40
MPCRKS
41
L
KR
42
S
G
43
L
C
YF
44
AG
45
YS
F
46
L
AIV
47
R
V
NDTE
48
Y
T
I
LVM
49
DN
EGSPA
50
A
ETNSD
51
Q
P
KS
ADE
52
N
G
KDSEA
53
VQGADE
54
T
GEA
55
T
R
N
AEKDQ
56
L
Q
T
N
SEKA
57
LIVA
58
V
ALM
I
59
V
S
Q
NKADE
60
Q
S
DEKGA
61
Y
AFML
62
HQDN
63
Q
NEDG
64
S
Y
FVQTKA
65
K
Q
TPNSDE
66
IVYWLF
67
A
E
K
DNQGM
68
T
K
N
DQEG
69
T
KNSR
70
Q
K
N
A
D
S
PT
71
V
MI
L
72
A
N
TVKR
73
LIV
0
1
2
3
4
bit
s
1
VL
I
2
FY
3
F
IV
4
G
5
SN
6
L
7 8
VASP
9
WFY
10
KA
E
TDQRS
11
F
MI
TVA
12
D
SRET
13
A
SRDQE
14
N
QADE
15
T
H
SQED
16
IVL
17
L
E
K
T
IQR
18
K
S
G
AQDE
19
T
SAVL
20
VF
21
TGESA
22
T
D
SAPEQ
23
HFY
24
A
G
25
P
KQTASE
26
IV
27
V
E
A
L
S
DTK
28
Q
KRNS
29
I
S
CAV
30
V
A
NRQSK
31
VI
L32
VM
IP
33
Y
S
N
I
VMLT
34
ED
35
KR
36
L
FDE
37ST
38R
K
G39
QKR
40
A
V
L
MPKS
41
KR
42
G43
LF
44
AG
45
F46
IV
47
DE
48
VLM
49
D
N
EPSGA
50
A
T
ENSD
51
S
N
K
AED
52
T
N
G
DSEA
53
S
I
G
V
QADE
54
GAE
55
N
KETRADQ
56
R
Q
STEKA
57
I
M
VA
58
A
MI
59
T
S
Q
NADE
60
K
SEDGA
61
V
A
ML
62
HQDN
63
ENDG
64
Y
S
R
KVQTA
65
N
Q
PTSDE
66
Y
M
VIFLW
67
RNK
DGM
68
N
G
69
R
70
Q
N
E
T
SADP
71
V
M
IL
72
M
NVTKR
73
IV
0
1
2
3
4
bit
s
1
VL
I
2
FY
3
IV
4
G
5
N
6
L7
P
8
N
KPS
9
R
WEQYF
10
G
S
N
TK
QEDR
11
L
T
IFVA
12
SDNTE
13
S
VP
REQ
14
DAQKE
15
T
H
ASED
16
FIVL
17L
K
D
T
I
E
18L
K
G
Q
TDEA
19
I
FQAVL
20
LF
21
Q
TKSA
22
T
A
PQSE
23
R
EI
AFVY
24
WSG
25
N
K
ATSDE
26
A
SGV
27
L
ATVSI
K
28
Q
TKSNR
29
I
A
TFVC
30
T
VAQSK
31
S
VI
AL
32
IVP
33
R
K
IF
VTL
34
ED
35
KR
36
KDE
37
ST
38
KG
39
G
QEAKR
40
S
VL
MPCK
41
R
42
G
43
F
44
GA
45
F
46
LIAV
47
NDTE
48
I
TLVM
49
V
DGESNA
50
A
ETNSD
51
S
A
PDE
52
T
Q
N
DSKEA
53
N
L
I
VAQDE
54
AE
55
S
KE
NATQD
56
TQLESKA
57
Y
F
ILVA
58
I
59
T
S
AQDE
60
S
EQGKDA
61
A
YFL
62
NDQ
63
NDG
64
Y
R
KQFTVA
65
M
SDTE
66
V
M
LFW
67
Q
F
KGNM
68
NEDG
69
VTNSR
70
E
N
Q
M
A
KDP
71
IL
72
S
KR
73
LIV
all prokaryotic RRM domains across tree
all cyanobacterial RRM domains across tree
prokaryotic RRM domains in prok-1 subtree
prokaryotic RRM domains in prok-2 subtree
prokaryotic RRM domains in prok-3 subtree (cyanobacteria)
259 domains
95 domains
27 domains
138 domains
76 domains
RNP2 RNP1
L5L4L3L2L1�2�1 �4�3�1
Fig. S22
161
9G8 ZnK
RSZ ZnK
RS2Z ZnK (right)
RS2Z ZnK (left)
C-�-X-C-G-±-X-G-H-X-X-X-�-C
45 domains
22 domains
13 domains
13 domains
0
1
2
3
4
bit
s
1
DG
2
HR
3
C
4
YF
5
N
6
C
7
G
8
VM
I
9
ED
10
G11
H12
W
13
VHA
14
R
15
ND
16
C
17
TK
18
A
0
1
2
3
4
bit
s
1
D2
KR
3
C4
Y
5
QE
6
C
7
G
8
G
DE
9
Q
TRK
10
G
11
H
12
FY
13
A
14
RY
15
HD
16
Y
C
17
S
R
Q
YH
18
KE
R
0
1
2
3
4
bit
s
1
SML
2
RK
3
C4
Y5
E6
C7
G
8
E
9
S
LI
ATP
10
G
11
H
12
IF
13
A
14
R
15
DE
16
C
17
NVR
18
RSNL
0
1
2
3
4
bit
s
1
DN
2
RK
3
C
4
FY
5
GR
6
C7
G8
DE
9
LR
10
G
11
H
12
I
13
LE
14
R
15
EDN
16
C
17
RQK
18
N
Fig. S23
162
Word density cumulative distributions <plotdist> - page 1
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
E after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
G after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
G before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
G between RRM 1 and RRM 2
asf-like-anim (50)asf-like-plt (23)
rs (12)srp40-55-75-ins (74)
Fig. S24
163
Word density cumulative distributions <plotdist> - page 2
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
G between RRM 1 and ZNK 1
9g8 (44)rs2z (7)rsz (13)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
K after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
P after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
P before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
Fig. S24
164
Word density cumulative distributions <plotdist> - page 3
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
R after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
R before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
R between RRM 1 and RRM 2
asf-like-anim (50)asf-like-plt (23)
rs (12)srp40-55-75-ins (74)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
R between RRM 1 and ZNK 1
9g8 (44)rs2z (7)rsz (13)
Fig. S24
165
Word density cumulative distributions <plotdist> - page 4
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
S after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
S before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
S between RRM 1 and RRM 2
asf-like-anim (50)asf-like-plt (23)
rs (12)srp40-55-75-ins (74)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
S between RRM 1 and ZNK 1
9g8 (44)rs2z (7)rsz (13)
Fig. S24
166
Word density cumulative distributions <plotdist> - page 5
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[GGG] between RRM 1 and RRM 2
asf-like-anim (50)asf-like-plt (23)
rs (12)srp40-55-75-ins (74)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[GGG] between RRM 1 and ZNK 1
9g8 (44)rs2z (7)rsz (13)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[GG] between RRM 1 and RRM 2
asf-like-anim (50)asf-like-plt (23)
rs (12)srp40-55-75-ins (74)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[GG] between RRM 1 and ZNK 1
9g8 (44)rs2z (7)rsz (13)
Fig. S24
167
Word density cumulative distributions <plotdist> - page 6
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[GR] before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[GR] between RRM 1 and RRM 2
asf-like-anim (50)asf-like-plt (23)
rs (12)srp40-55-75-ins (74)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[GR] between RRM 1 and ZNK 1
9g8 (44)rs2z (7)rsz (13)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[GS] before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
Fig. S24
168
Word density cumulative distributions <plotdist> - page 7
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[GS] between RRM 1 and RRM 2
asf-like-anim (50)asf-like-plt (23)
rs (12)srp40-55-75-ins (74)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[KS] after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[PPP] after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[PP] after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
Fig. S24
169
Word density cumulative distributions <plotdist> - page 8
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[PRS] after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[PS] after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[RR] after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[RS] after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
Fig. S24
170
Word density cumulative distributions <plotdist> - page 9
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[RS] before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[RS] between RRM 1 and ZNK 1
9g8 (44)rs2z (7)rsz (13)
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[SSS] after last domain
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[SSS] before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
Fig. S24
171
Word density cumulative distributions <plotdist> - page 10
0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[SS] before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42) 0
10
20
30
40
50
60
70
80
90
100
0 1 2 3 4 5 6 7 8
cum
ulat
ive
freq
uenc
y (%
)
max word density (24-AA window)
[ST] before RRM 1
9g8 (47)asf-like-anim (55)
asf-like-plt (23)rnps1 (39)
rs (13)rs2z (7)rsz (14)
sc35 (53)scl (21)sr45 (8)
srp20 (44)srp40-55-75-ins (97)
srrp (42)
Fig. S24
172
0
4
8
12
16
20
0 50 100 150 200
com
posi
tion
A. SC35
0
8
16
24
cons
erva
tion
N CRRM1
0
4
8
12
0 50 100 150 200
com
posi
tion
B. SCL
0
8
16
24
cons
erva
tion
N CRRM1
0
4
8
12
0 50 100 150 200 250
com
posi
tion
C. SRrp
0
10
20
30
cons
erva
tion
N CRRM1
0
4
8
12
16
0 50 100 150 200
com
posi
tion
D. 9G8
0
10
20
30
cons
erva
tion
N CZ1RRM1
0
4
8
12
16
0 20 40 60 80 100 120 140 160
com
posi
tion
E. SRp20
0
10
20
30
cons
erva
tion
N CRRM1
0
4
8
12
0 20 40 60 80 100 120 140 160 180
com
posi
tion
F. RSZ
0
8
16
24
cons
erva
tion
N CRRM1 ZNK1
0
4
8
12
16
0 50 100 150 200 250 300
com
posi
tion
G. RS2Z
0
10
20
30
cons
erva
tion
N CZ1 Z2RRM1
0
4
8
12
16
20
0 50 100 150 200
com
posi
tion
H. ASF/SF2
0
8
16
24
cons
erva
tion
N CRRM2RRM1
RS
RS
RS
G
G
R
S
KS
KP
R
PS
R
GR E
S
P
G
GG
GR
R
S P
RS
R
SRS
PK KS
RS
G
P
R
S
GR
RS
R
S
G
P
RS
R
S
Fig. S25
173
0
3
6
9
0 50 100 150 200
com
posi
tion
I. SRp30c
0
8
16
24
cons
erva
tion
N CRRM2RRM1
0
4
8
12
16
0 50 100 150 200 250
com
posi
tion
J. ASF-like (plants)
0
8
16
24
cons
erva
tion
N CRRM1 RRM2
0
4
8
12
16
20
0 50 100 150 200 250
com
posi
tion
K. SRp40
0
8
16
24
cons
erva
tion
N CRRM1 RRM2
0
4
8
12
16
20
0 50 100 150 200 250 300
com
posi
tion
L. SRp55
0
8
16
24
cons
erva
tion
N CRRM2RRM1
0
4
8
12
16
0 50 100 150 200 250 300 350 400 450
com
posi
tion
M. SRp75
0
8
16
24
cons
erva
tion
N CRRM2RRM1
0
5
10
0 50 100 150 200 250 300 350
com
posi
tion
N. RS
0
8
16
24
cons
erva
tion
N CRRM2RRM1
0
4
8
12
16
0 50 100 150 200 250 300 350 400
com
posi
tion
O. SR45
0
8
16
24
cons
erva
tion
N CRRM1
0
4
8
12
16
20
0 50 100 150 200 250 300
com
posi
tion
P. RNPS1
0
8
16
24
cons
erva
tion
N CRRM1
G
P
R
S
RS RS
G
S
R
KKS
RS
G
R S KS
SS
R
E
PS
RS
RS
R
S
GK
KS
RS
K
P
R
S
PPSS
SSS
RS
G
K
R
S
KS
S
SS
SSS
ST
P
R
PPRS
Fig. S25
174
98
90
100 86
67
82
100
100
100 77
72
99
100
100 68
100
99 84
68 85
60
100
55
98 55
100
61
55 52
100
65 71
79
51
asflkpl-Volvox carteri@jgi Volca1 72532 RRM 1[KOG0105]asflkan-Caenorhabditis elegans@Y111B2A_18_3_RRM_1[SR|CeSF2/ASF/rsp-3][KOG0105]
asflkpl-Chlamydomonas reinhardtii@jgi_Chlre3_129159_RRM_1[KOG0105]asflkpl-Volvox carteri@jgi_Volca1_45192_RRM_1[KOG0105]
asflkpl-Chlorella sp._NC64A@jgi_ChlNC64A_1_36976_estExt_Genewise1Plus___RRM_1[KOG0105]asflkpl-Oryza sativa_japonica_cultivar_group@NP_001060608_RRM_1[SR|SRp33a][KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_250704_gw1_XV_140_1_RRM_1[SR|SRp34a][KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_421685_gw1_XII_145_1_RRM_1[SR|SRp34a][KOG0105]
asflkpl-Arabidopsis thaliana@NP_001078264_RRM_1[SR|SRp34a][KOG0105]asflkpl-Arabidopsis thaliana@NP_190512_RRM_1[SR|SRp34a][KOG0105]
asflkpl-Physcomitrella patens@jgi_Phypa1_1_140978_RRM_1[KOG0105]asflkpl-Physcomitrella patens@jgi_Phypa1_1_113630_RRM_1[KOG0105]
asflkpl-Physcomitrella patens@jgi_Phypa1_1_205547_RRM_1[KOG0105]asflkpl-Selaginella moellendorfii@jgi_Selmo1_36388_gw1_41_236_1_RRM_1[KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_811208_fgenesh4_pm___RRM_1[KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_773626_fgenesh4_pg___RRM_1[SR|SRp30][KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_409414_gw1_II_749_1_RRM_1[KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_664446_grail3_0061020502_RRM_1[SR|SRp33a][KOG0105]
asflkpl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049442_Sb01g035680_RRM_1[SR|SRp32][KOG0105]asflkpl-Oryza sativa_japonica_cultivar_group@NP_001050082_RRM_1[SR|SRp32][KOG0105]
asflkpl-Selaginella moellendorfii@jgi_Selmo1_119951_e_gw1_61_278_1_RRM_1[KOG0105]asflkpl-Selaginella moellendorfii@jgi_Selmo1_97566_e_gw1_19_485_1_RRM_1[KOG0105]
asflkpl-Sorghum bicolor_BTx623@jgi_Sorbi1_5035702_Sb03g013010_RRM_1[SR|SR20][KOG0105]asflkan-Mus musculus@ENSMUSP00000031513_RRM_1[SR|SRp30c][KOG0105]
asflkan-Homo sapiens@ENSP00000229390_RRM_1[SR|SRp30c][KOG0105]asflkan-Drosophila melanogaster@CG6987_PA_RRM_1[KOG0105]
asflkan-Homo sapiens@ENSP00000258962_RRM_1[SR|ASF/SF2][KOG0105]asflkan-Mus musculus@ENSMUSP00000078792_RRM_1[SR|ASF/SF2][KOG0105]asflkan-Mus musculus@ENSMUSP00000103553_RRM_1[SR|ASF/SF2][KOG0105]
asflkpl-Oryza sativa_japonica_cultivar_group@NP_001055323_RRM_1[SR|SRp33b][KOG0105]asflkpl-Arabidopsis thaliana@NP_683288_RRM_1[SR|SRp30][KOG0105]asflkpl-Arabidopsis thaliana@NP_172386_RRM_1[SR|SRp30][KOG0105]
asflkpl-Arabidopsis thaliana@NP_849537_RRM_1[SR|SRp34b][KOG0105]asflkpl-Arabidopsis thaliana@NP_567235_RRM_1[SR|SRp34b][KOG0105]
asflkpl-Arabidopsis thaliana@NP_850933_RRM_1[SR|SR1/SRp34][KOG0105]asflkpl-Arabidopsis thaliana@NP_850934_RRM_1[SR|SR1/SRp34][KOG0105]
9g8-Caenorhabditis elegans@C33H5_12c_RRM_1[SR|CeSRp20/rsp-6][KOG0107]9g8-Caenorhabditis elegans@C33H5_12b_1_RRM_1[SR|CeSRp20/rsp-6][KOG0107]9g8-Caenorhabditis elegans@C33H5_12a_2_RRM_1[SR|CeSRp20/rsp-6][KOG0116]
9g8-Drosophila melanogaster@CG1987_PA_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PD_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PB_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PC_RRM_1[KOG0107]
srp20-Drosophila melanogaster@CG10203_PA_RRM_1[SR|9G8][KOG0107]srp20-Mus musculus@ENSMUSP00000100538_RRM_1[SR|SRp20][KOG0107]
srp20-Mus musculus@ENSMUSP00000110365_RRM_1[SR|SRp20][KOG0107]srp20-Homo sapiens@ENSP00000344762_RRM_1[SR|SRp20][KOG0107]srp20-Mus musculus@ENSMUSP00000049025_RRM_1[SR|SRp20][KOG0107]srp20-Homo sapiens@ENSP00000362820_RRM_1[SR|SRp20][KOG0107]
9g8-Homo sapiens@ENSP00000325905_RRM_1[SR|9G8]9g8-Mus musculus@ENSMUSP00000066393_RRM_1[SR|9G8][KOG0107]9g8-Homo sapiens@ENSP00000368134_RRM_1[SR|9G8][KOG0107]9g8-Homo sapiens@ENSP00000368146_RRM_1[SR|9G8][KOG0107]9g8-Mus musculus@ENSMUSP00000070983_RRM_1[SR|9G8][KOG0107]9g8-Mus musculus@ENSMUSP00000108040_RRM_1[SR|9G8][KOG0107]
9g8-Drosophila melanogaster@CG5655_PA_RRM_1[KOG0107]rsz-Chlorella sp._NC64A@jgi_ChlNC64A_1_139931_IGS_gm_27_00109_RRM_1[KOG0107]
rsz-Chlamydomonas reinhardtii@jgi_Chlre3_132362_RRM_1[KOG0107]rsz-Chlamydomonas reinhardtii@jgi_Chlre3_192053_RRM_1[KOG0107]
rsz-Volvox carteri@jgi_Volca1_121301_RRM_1[KOG0107]rsz-Chlorella sp._NC64A@jgi_ChlNC64A_1_135849_IGS_gm_14_00382_RRM_1
rsz-Populus trichocarpa@jgi_Poptr1_1_248500_gw1_XIX_900_1_RRM_1[SR|SRZ21/RSZ21][KOG0107]rsz-Physcomitrella patens@jgi_Phypa1_1_143810_RRM_1[KOG0107]rsz-Physcomitrella patens@jgi_Phypa1_1_151194_RRM_1[KOG0107]
rsz-Oryza sativa_japonica_cultivar_group@NP_001057018_RRM_1[SR|RSZp21a]rsz-Oryza sativa_japonica_cultivar_group@NP_001047400_RRM_1[SR|RSZp23][KOG0107]
rsz-Sorghum bicolor_BTx623@jgi_Sorbi1_5061430_Sb10g005960_RRM_1[SR|RSZp21a]rsz-Sorghum bicolor_BTx623@jgi_Sorbi1_5056021_Sb04g035540_RRM_1[SR|RSZp21b]
rsz-Oryza sativa_japonica_cultivar_group@NP_001048352_RRM_1[SR|RSZp21b]rsz-Selaginella moellendorfii@jgi_Selmo1_172361_estExt_Genewise1Plus___RRM_1[KOG0107]rsz-Selaginella moellendorfii@jgi_Selmo1_68846_gw1_3_1555_1_RRM_1[KOG0107]
rsz-Populus trichocarpa@jgi_Poptr1_1_261622_gw1_XVIII_2163_1_RRM_1[KOG0116]rsz-Populus trichocarpa@jgi_Poptr1_1_583120_eugene3_01470005_RRM_1[SR|RSZ22a]rsz-Populus trichocarpa@jgi_Poptr1_1_583122_eugene3_01470007_RRM_1[SR|RSZp21a][KOG0107]
rsz-Arabidopsis thaliana@NP_180035_RRM_1[SR|RSZ22a]rsz-Arabidopsis thaliana@NP_194886_RRM_1[SR|SRZ22/RSZ22][KOG0107]
rsz-Arabidopsis thaliana@NP_564208_RRM_1[SR|SRZ21/RSZ21]
9G8SRp20
RSZ
"plant"
ASF-like
"animal"
ASF-like
"plant"
N3
N4
Fig. S26
175
90
81
51 57
50
91
83 78
99
99 86
52
94
83 78
85 58
97
100
98
95
98 98
100 69
99
95
74
80
90
82
74
100
96100
100
92 92
77
100 77
100
51
68
91
97
83
100 67
88
56
98 87
95
98
100
scl-Chlamydomonas reinhardtii@jgi Chlre3 116256 RRM 1scl-Selaginella moellendorfii@jgi_Selmo1_8401_gw1_62_42_1_RRM_1[KOG4207]
scl-Physcomitrella patens@jgi_Phypa1_1_108464_RRM_1scl-Physcomitrella patens@jgi_Phypa1_1_141868_RRM_1
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5056881_Sb05g027700_RRM_1scl-Arabidopsis thaliana@NP_567021_RRM_1[SR|SCL30][KOG0122]
scl-Populus trichocarpa@jgi_Poptr1_1_656109_grail3_0049021701_RRM_1[KOG0122]scl-Populus trichocarpa@jgi_Poptr1_1_227475_gw1_X_2172_1_RRM_1[KOG0127]
scl-Oryza sativa_japonica_cultivar_group@NP_001068546_RRM_1[KOG0127]scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5047478_Sb0514s002010_RRM_1[KOG0110]
scl-Oryza sativa_japonica_cultivar_group@NP_001046448_RRM_1[SR|SCL30a]scl-Oryza sativa_japonica_cultivar_group@NP_001067091_RRM_1[SR|SCL30b]
scl-Selaginella moellendorfii@jgi_Selmo1_8339_gw1_49_32_1_RRM_1[KOG4207]scl-Oryza sativa_japonica_cultivar_group@NP_001050168_RRM_1
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049384_Sb01g034590_RRM_1[KOG0127]scl-Populus trichocarpa@jgi_Poptr1_1_814124_estExt_fgenesh4_kg___RRM_1
scl-Arabidopsis thaliana@NP_197382_RRM_1[SR|SCL28][KOG0127]scl-Populus trichocarpa@jgi_Poptr1_1_420699_gw1_VIII_2127_1_RRM_1[SR|SCL28]
scl-Selaginella moellendorfii@jgi_Selmo1_102070_e_gw1_25_62_1_RRM_1[KOG0148]scl-Selaginella moellendorfii@jgi_Selmo1_79810_e_gw1_3_146_1_RRM_1[KOG4207]
scl-Populus trichocarpa@jgi_Poptr1_1_256035_gw1_XVI_1974_1_RRM_1[SR|SCL25][KOG0111]scl-Populus trichocarpa@jgi_Poptr1_1_547618_eugene3_00010059_RRM_1
scl-Arabidopsis thaliana@NP_187966_RRM_1[SR|SCL30a]scl-Arabidopsis thaliana@NP_564685_RRM_1[SR|SR33/SCL33][KOG0110]scl-Arabidopsis thaliana@NP_001031195_RRM_1[SR|SR33/SCL33][KOG0110]
scl-Oryza sativa_japonica_cultivar_group@NP_001060372_RRM_1[SR|SCL25]scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5052097_Sb02g040350_RRM_1[SR|SCL25]
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049360_Sb01g034200_RRM_1scl-Oryza sativa_japonica_cultivar_group@NP_001050213_RRM_1[KOG4207]
2rs-Chlorella sp._NC64A@jgi_ChlNC64A_1_25380_e_gw1_15_148_1_RRM_22rs-Cyanidioschyzon merolae@gnl_CMER_CMO009C_RRM_22rs-Chlamydomonas reinhardtii@jgi_Chlre3_120019_RRM_2[KOG0106]
2rs-Chlamydomonas reinhardtii@jgi_Chlre3_80366_RRM_2[KOG0106]2rs-Volvox carteri@jgi_Volca1_80657_RRM_1
2rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5054582_Sb04g001910_RRM_22rs-Oryza sativa_japonica_cultivar_group@NP_001045729_RRM_2
2rs-Oryza sativa_japonica_cultivar_group@NP_001052061_RRM_22rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5056945_Sb06g001100_RRM_2
2rs-Arabidopsis thaliana@NP_973702_RRM_12rs-Arabidopsis thaliana@NP_182184_RRM_2
2rs-Populus trichocarpa@jgi_Poptr1_1_552308_eugene3_00021623_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_245070_gw1_XIV_1813_1_RRM_2
2rs-Arabidopsis thaliana@NP_567120_RRM_22rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5030607_Sb01g049590_RRM_2
2rs-Arabidopsis thaliana@NP_851174_RRM_22rs-Arabidopsis thaliana@NP_200017_RRM_2
2rs-Arabidopsis thaliana@NP_974616_RRM_1[SR|RSp40/SRp35][KOG0106]2rs-Arabidopsis thaliana@NP_194280_RRM_22rs-Arabidopsis thaliana@NP_001078447_RRM_1
2rs-Physcomitrella patens@jgi_Phypa1_1_167387_RRM_22rs-Selaginella moellendorfii@jgi_Selmo1_124209_e_gw1_74_375_1_RRM_22rs-Selaginella moellendorfii@jgi_Selmo1_82477_e_gw1_5_1267_1_RRM_2
2rs-Populus trichocarpa@jgi_Poptr1_1_423171_gw1_XII_1631_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_253698_gw1_XV_3134_1_RRM_2
2rs-Populus trichocarpa@jgi_Poptr1_1_411608_gw1_II_2943_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_244286_gw1_XIV_1029_1_RRM_2
rs2z-Arabidopsis thaliana@NP_850280_RRM_1[SR|RSZ33][KOG0107]rs2z-Arabidopsis thaliana@NP_190918_RRM_1[SR|RSZ32][KOG0107]
rs2z-Oryza sativa_japonica_cultivar_group@NP_001042066_RRM_1[SR|RSZ37a][KOG0109]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5052652_Sb03g005500_RRM_1[KOG0109]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5059999_Sb09g001910_RRM_1[SR|RSZ36][KOG0109]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5060000_Sb09g001920_RRM_1[SR|RSZ36][KOG0106]
rs2z-Oryza sativa_japonica_cultivar_group@NP_001054489_RRM_1[SR|RSZ36][KOG0109]rs2z-Oryza sativa_japonica_cultivar_group@NP_001049771_RRM_1[SR|RSZ37b][KOG0109]
rs2z-Populus trichocarpa@jgi_Poptr1_1_667717_grail3_0004036801_RRM_1[SR|RSZ37b][KOG0107]rs2z-Populus trichocarpa@jgi_Poptr1_1_653760_grail3_0013007302_RRM_1[SR|RSZ37b][KOG0107]
rs2z-Oryza sativa_japonica_cultivar_group@NP_001054731_RRM_1[SR|RSZ39]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045949_Sb09g004685_RRM_1[KOG0106]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045954_Sb09g004726_RRM_1[KOG0107]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045953_Sb09g004723_RRM_1[KOG0109]
srp457-Caenorhabditis elegans@T28D9_2d_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]srp457-Caenorhabditis elegans@T28D9_2a_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]srp457-Caenorhabditis elegans@T28D9_2b_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]
srp457-Homo sapiens@ENSP00000342294_RRM_1[SR|SRp40][KOG0106]srp457-Mus musculus@ENSMUSP00000021562_RRM_1[SR|SRp40][KOG0106]srp457-Mus musculus@ENSMUSP00000105985_RRM_1[SR|SRp40][KOG0106]srp457-Mus musculus@ENSMUSP00000105983_RRM_1[SR|SRp40][KOG0106]srp457-Homo sapiens@ENSP00000377892_RRM_1[SR|SRp40][KOG0105]
srp457-Homo sapiens@ENSP00000362900_RRM_1[SR|SRp75][KOG0105]srp457-Mus musculus@ENSMUSP00000061474_RRM_1[SR|SRp75][KOG0105]
srp457-Mus musculus@ENSMUSP00000017065_RRM_1[SR|SRp55][KOG0105]srp457-Homo sapiens@ENSP00000244020_RRM_1[SR|SRp55][KOG0105]srp457-Homo sapiens@ENSP00000362251_RRM_1[SR|SRp55][KOG0106]
srp457-Caenorhabditis elegans@W02B12_2_RRM_1[SR|CeSRp40/rsp-2][KOG0106]srp457-Caenorhabditis elegans@W02B12_3a_RRM_1[SR|CeSRp75/rsp-1][KOG0106]srp457-Caenorhabditis elegans@W02B12_3b_RRM_1[SR|CeSRp75/rsp-1][KOG0106]srp457-Caenorhabditis elegans@W02B12_3c_RRM_1[SR|CeSRp75/rsp-1][KOG0106]
srp457-Drosophila melanogaster@CG10851_PB_RRM_1[SR|SRp55][KOG0106]srp457-Drosophila melanogaster@CG10851_PC_RRM_1[SR|SRp55][KOG0105]srp457-Drosophila melanogaster@CG10851_PE_RRM_1[SR|SRp55][KOG0105]srp457-Drosophila melanogaster@CG10851_PF_RRM_1[SR|Hrp45][KOG0106]srp457-Drosophila melanogaster@CG10851_PD_RRM_1[SR|Hrp45][KOG0106]
asflkpl-Ostreococcus lucimarinus@jgi_Ost9901_3_8794_RRM_1[KOG0105]asflkpl-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16551_gw1_5_1077_1_RRM_1[KOG0105]
rs-Chlorella sp._NC64A@jgi_ChlNC64A_1_25380_e_gw1_15_148_1_RRM_1[KOG0106]rs-Cyanidioschyzon merolae@gnl_CMER_CMO009C_RRM_1
rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5056945_Sb06g001100_RRM_1[SR|RSp29][KOG0106]rs-Oryza sativa_japonica_cultivar_group@NP_001052061_RRM_1[SR|RSp29][KOG0106]
rs-Populus trichocarpa@jgi_Poptr1_1_245070_gw1_XIV_1813_1_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_552308_eugene3_00021623_RRM_1[KOG0106]
rs-Arabidopsis thaliana@NP_567120_RRM_1[SR|RSp31][KOG0106]rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5030607_Sb01g049590_RRM_1[KOG0106]
rs-Arabidopsis thaliana@NP_182184_RRM_1[SR|RSp31a][KOG0106]rs-Physcomitrella patens@jgi_Phypa1_1_167387_RRM_1[KOG0106]
rs-Selaginella moellendorfii@jgi_Selmo1_82477_e_gw1_5_1267_1_RRM_1[KOG0106]rs-Selaginella moellendorfii@jgi_Selmo1_124209_e_gw1_74_375_1_RRM_1[KOG0106]
rs-Populus trichocarpa@jgi_Poptr1_1_253698_gw1_XV_3134_1_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_423171_gw1_XII_1631_1_RRM_1[KOG0106]
rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5054582_Sb04g001910_RRM_1[KOG0106]rs-Oryza sativa_japonica_cultivar_group@NP_001045729_RRM_1[SR|RSp33][KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_244286_gw1_XIV_1029_1_RRM_1[KOG0106]
rs-Populus trichocarpa@jgi_Poptr1_1_644386_grail3_0033034501_RRM_1[SR|RSp33][KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_411608_gw1_II_2943_1_RRM_1[SR|RSp33][KOG0106]
rs-Arabidopsis thaliana@NP_194280_RRM_1[SR|RSp40/SRp35][KOG0106]rs-Arabidopsis thaliana@NP_851174_RRM_1[SR|RSp41][KOG0106]rs-Arabidopsis thaliana@NP_200017_RRM_1[SR|RSp41][KOG0106]
rs-Chlamydomonas reinhardtii@jgi_Chlre3_120019_RRM_1rs-Chlamydomonas reinhardtii@jgi_Chlre3_80366_RRM_1
asflkpl-Chlamydomonas reinhardtii@jgi_Chlre3_120469_RRM_1[KOG0105]asflkpl Volvox carteri@jgi_Volca1_72532_RRM_1[KOG0105]
SRp40
SRp55
SRp75
RRM1
RS "plant"
RS2Z
"plant"
SCL
RRM2
RS
"plant"
N6Fig. S26
176
0.12
76
99 97
55
65
100
73
100
97 63
52
70
93
83
87
100 53
100 75 61
51
93
68
57
66
66100
100
100
98
75
90
100
rnps1-Caenorhabditis elegans@K02F3_11_1_RRM_1[KOG4209]rnps1-Drosophila melanogaster@CG41105_PC_RRM_1
rnps1-Drosophila melanogaster@CG16788_PA_RRM_1rnps1-Mus musculus@ENSMUSP00000057332_RRM_1[KOG4209]
rnps1-Homo sapiens@ENSP00000380275_RRM_1[RNPS1|RNPS1][KOG4209]rnps1-Mus musculus@ENSMUSP00000111025_RRM_1[RNPS1|RNPS1][KOG4209]rnps1-Mus musculus@ENSMUSP00000111028_RRM_1[RNPS1|RNPS1][KOG4209]
sr45-Volvox carteri@jgi_Volca1_105177_RRM_1[KOG0462]sr45-Chlorella sp._NC64A@jgi_ChlNC64A_1_138910_IGS_gm_22_00151_RRM_1
sr45-Micromonas pusilla_RCC299@jgi_MicpuN3_63440_EuGene_1300010090_RRM_1sr45-Micromonas pusilla_CCMP1545@jgi_MicpuC2_9037_gw1_7_479_1_RRM_1
sr45-Selaginella moellendorfii@jgi_Selmo1_446044_estExt_fgenesh2_pg___RRM_1[KOG0122]sr45-Selaginella moellendorfii@jgi_Selmo1_424875_fgenesh2_pg___RRM_1[KOG0122]
sr45-Physcomitrella patens@jgi_Phypa1_1_166555_RRM_1sr45-Physcomitrella patens@jgi_Phypa1_1_105411_RRM_1
sr45-Populus trichocarpa@jgi_Poptr1_1_823076_estExt_fgenesh4_pg___RRM_1sr45-Arabidopsis thaliana@NP_173107_RRM_1[SR|SR45]sr45-Arabidopsis thaliana@NP_973844_RRM_1[SR|SR45]
sr45-Oryza sativa_japonica_cultivar_group@NP_001054414_RRM_1[KOG0117]sr45-Oryza sativa_japonica_cultivar_group@NP_001045458_RRM_1
sr45-Sorghum bicolor_BTx623@jgi_Sorbi1_5054420_Sb03g046480_RRM_1sc35-Micromonas pusilla_CCMP1545@jgi_MicpuC2_9129_gw1_3_931_1_RRM_1[KOG4207]
sc35-Micromonas pusilla_RCC299@jgi_MicpuN3_91839_estExt_Genewise2___RRM_1[KOG4207]sc35-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16908_gw1_5_1114_1_RRM_1[KOG4207]
sc35-Ostreococcus lucimarinus@jgi_Ost9901_3_8174_RRM_1[KOG4207]sc35-Drosophila melanogaster@CG5442_PB_RRM_1[SR|SC35][KOG4207]
sc35-Caenorhabditis elegans@EEED8_7a_RRM_1[SR|CeSC35/rsp-4]sc35-Caenorhabditis elegans@EEED8_7b_RRM_1[SR|CeSC35/rsp-4][KOG4207]
sc35-Mus musculus@ENSMUSP00000078984_RRM_1[KOG4207]sc35-Homo sapiens@ENSP00000381889_RRM_1[KOG4207]
sc35-Mus musculus@ENSMUSP00000090059_RRM_1[SR|SC35][KOG4368]sc35-Homo sapiens@ENSP00000293233_RRM_1[SR|SC35][KOG4368]sc35-Homo sapiens@ENSP00000353089_RRM_1[SR|SC35][KOG4368]sc35-Mus musculus@ENSMUSP00000072182_RRM_1[SR|SC35][KOG4207]
sc35-Oryza sativa_japonica_cultivar_group@NP_001060322_RRM_1[SR|SC35b][KOG4207]sc35-Arabidopsis thaliana@NP_851261_RRM_1[SR|SC35][KOG4207]
sc35-Populus trichocarpa@jgi_Poptr1_1_672394_grail3_1445000102_RRM_1[SR|SC35a][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_645719_grail3_0067008905_RRM_1[SR|SC35b][KOG4207]
sc35-Populus trichocarpa@jgi_Poptr1_1_709848_estExt_Genewise1___RRM_1[KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_559112_eugene3_00050727_RRM_1[SR|SC35a][KOG4207]
sc35-Oryza sativa_japonica_cultivar_group@NP_001062094_RRM_1[SR|SC35a][KOG0415]sc35-Oryza sativa_japonica_cultivar_group@NP_001050263_RRM_1[SR|SC35c][KOG4207]
sc35-Sorghum bicolor_BTx623@jgi_Sorbi1_5029845_Sb01g033710_RRM_1[KOG4207]sc35-Sorghum bicolor_BTx623@jgi_Sorbi1_5059167_Sb07g029000_RRM_1[KOG0147]
sc35-Selaginella moellendorfii@jgi_Selmo1_134332_e_gw1_124_43_1_RRM_1[SR|SC35a][KOG4207]sc35-Cyanidioschyzon merolae@gnl_CMER_CML202C_RRM_1
sc35-Physcomitrella patens@jgi_Phypa1_1_122960_RRM_1[KOG4207]sc35-Physcomitrella patens@jgi_Phypa1_1_172957_RRM_1[KOG0415]
sc35-Selaginella moellendorfii@jgi_Selmo1_7952_gw1_7_122_1_RRM_1[SR|SC35a][KOG4207]scl-Micromonas pusilla_RCC299@jgi_MicpuN3_74643_gw2_11_587_1_RRM_1[KOG0107]
scl-Micromonas pusilla_CCMP1545@jgi_MicpuC2_11901_gw1_8_619_1_RRM_1[KOG4207]scl-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16959_gw1_4_1177_1_RRM_1[KOG0108]
scl-Ostreococcus lucimarinus@jgi_Ost9901_3_9858_RRM_1[KOG0108]scl-Ostreococcus tauri@jgi_Ostta4_7793_RRM_1[KOG0108]
scl-Chlorella sp._NC64A@jgi_ChlNC64A_1_135593_IGS_gm_14_00126_RRM_1[KOG4207]srrp-Homo sapiens@ENSP00000358479_RRM_1[SRrp|SRrp35]
srrp-Mus musculus@ENSMUSP00000103794_RRM_1[SRrp|SRrp35][KOG0111]srrp-Mus musculus@ENSMUSP00000095455_RRM_1[SRrp|SRp38]srrp-Mus musculus@ENSMUSP00000101479_RRM_1[SRrp|SRp38][KOG0415]srrp-Homo sapiens@ENSP00000340764_RRM_1[SRrp|SRp38][KOG0111]srrp-Mus musculus@ENSMUSP00000030438_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000363577_RRM_1[SRrp|SRp38][KOG0111]srrp-Mus musculus@ENSMUSP00000099603_RRM_1[SRrp|SRp38][KOG0111]srrp-Mus musculus@ENSMUSP00000030437_RRM_1[SRrp|SRp38][KOG0415]srrp-Homo sapiens@ENSP00000345293_RRM_1[SRrp|SRp38]srrp-Homo sapiens@ENSP00000363573_RRM_1[SRrp|SRp38][KOG0415]srrp-Homo sapiens@ENSP00000342913_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000363576_RRM_1[SRrp|SRp38][KOG0111]
scl-Volvox carteri@jgi_Volca1_120666_RRM_1scl-Chlamydomonas reinhardtii@jgi_Chlre3_188086_RRM_1
scl-Volvox carteri@jgi_Volca1_73973_RRM_1[KOG4207]scl-Chlamydomonas reinhardtii@jgi_Chlre3_113900_RRM_1[KOG4207]
scl-Chlorella sp._NC64A@jgi_ChlNC64A_1_17896_gw1_13_295_1_RRM_1scl-Volvox carteri@jgi_Volca1_121229_RRM_1[KOG0415]
scl Chlamydomonas reinhardtii@jgi_Chlre3_116256_RRM_1
SC35
SRrp
RNPS1
SR45
N1
N2
Fig. S26
177
88
100 81
100
56
70
100
81
100
100 72
89
99
92
63
91 86
88
100 67
99 89
95
83 50
93
100
100
97
99 97
100 94
96
99 54
52
60
90
80
asflkpl-Populus trichocarpa@jgi Poptr1 1 421685 gw1 XII 145 1 RRM 1[SR|SRp34a][KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_250704_gw1_XV_140_1_RRM_1[SR|SRp34a][KOG0105]
asflkpl-Arabidopsis thaliana@NP_190512_RRM_1[SR|SRp34a][KOG0105]asflkpl-Arabidopsis thaliana@NP_001078264_RRM_1[SR|SRp34a][KOG0105]
asflkpl-Physcomitrella patens@jgi_Phypa1_1_140978_RRM_1[KOG0105]asflkpl-Physcomitrella patens@jgi_Phypa1_1_113630_RRM_1[KOG0105]
asflkpl-Selaginella moellendorfii@jgi_Selmo1_36388_gw1_41_236_1_RRM_1[KOG0105]asflkpl-Physcomitrella patens@jgi_Phypa1_1_205547_RRM_1[KOG0105]
asflkpl-Selaginella moellendorfii@jgi_Selmo1_97566_e_gw1_19_485_1_RRM_1[KOG0105]asflkpl-Selaginella moellendorfii@jgi_Selmo1_119951_e_gw1_61_278_1_RRM_1[KOG0105]
asflkpl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049442_Sb01g035680_RRM_1[SR|SRp32][KOG0105]asflkpl-Oryza sativa_japonica_cultivar_group@NP_001050082_RRM_1[SR|SRp32][KOG0105]
asflkpl-Sorghum bicolor_BTx623@jgi_Sorbi1_5035702_Sb03g013010_RRM_1[SR|SR20][KOG0105]asflkpl-Oryza sativa_japonica_cultivar_group@NP_001055323_RRM_1[SR|SRp33b][KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_811208_fgenesh4_pm____RRM_1asflkpl-Populus trichocarpa@jgi_Poptr1_1_773626_fgenesh4_pg___RRM_1[SR|SRp30][KOG0105]
asflkpl-Arabidopsis thaliana@NP_683288_RRM_1[SR|SRp30][KOG0105]asflkpl-Arabidopsis thaliana@NP_172386_RRM_1[SR|SRp30][KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_409414_gw1_II_749_1_RRM_1[KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_664446_grail3_0061020502_RRM_1[SR|SRp33a][KOG0105]asflkpl-Arabidopsis thaliana@NP_849537_RRM_1[SR|SRp34b][KOG0105]asflkpl-Arabidopsis thaliana@NP_567235_RRM_1[SR|SRp34b][KOG0105]asflkpl-Arabidopsis thaliana@NP_850934_RRM_1[SR|SR1/SRp34][KOG0105]asflkpl-Arabidopsis thaliana@NP_850933_RRM_1[SR|SR1/SRp34][KOG0105]
asflkpl-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16551_gw1_5_1077_1_RRM_1[KOG0105]asflkpl-Ostreococcus lucimarinus@jgi_Ost9901_3_8794_RRM_1[KOG0105]
rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5056945_Sb06g001100_RRM_1[SR|RSp29][KOG0106]rs-Oryza sativa_japonica_cultivar_group@NP_001052061_RRM_1[SR|RSp29][KOG0106]
rs-Populus trichocarpa@jgi_Poptr1_1_245070_gw1_XIV_1813_1_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_552308_eugene3_00021623_RRM_1[KOG0106]rs-Arabidopsis thaliana@NP_567120_RRM_1[SR|RSp31][KOG0106]
rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5030607_Sb01g049590_RRM_1[KOG0106]rs-Arabidopsis thaliana@NP_182184_RRM_1[SR|RSp31a][KOG0106]
rs-Arabidopsis thaliana@NP_194280_RRM_1[SR|RSp40/SRp35][KOG0106]rs-Arabidopsis thaliana@NP_851174_RRM_1[SR|RSp41][KOG0106]rs-Arabidopsis thaliana@NP_200017_RRM_1[SR|RSp41][KOG0106]
rs-Populus trichocarpa@jgi_Poptr1_1_423171_gw1_XII_1631_1_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_253698_gw1_XV_3134_1_RRM_1[KOG0106]
rs-Physcomitrella patens@jgi_Phypa1_1_167387_RRM_1[KOG0106]rs-Selaginella moellendorfii@jgi_Selmo1_124209_e_gw1_74_375_1_RRM_1[KOG0106]rs-Selaginella moellendorfii@jgi_Selmo1_82477_e_gw1_5_1267_1_RRM_1[KOG0106]rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5054582_Sb04g001910_RRM_1[KOG0106]
rs-Oryza sativa_japonica_cultivar_group@NP_001045729_RRM_1[SR|RSp33][KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_244286_gw1_XIV_1029_1_RRM_1[KOG0106]
rs-Populus trichocarpa@jgi_Poptr1_1_644386_grail3_0033034501_RRM_1[SR|RSp33][KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_411608_gw1_II_2943_1_RRM_1[SR|RSp33][KOG0106]
rs-Chlorella sp._NC64A@jgi_ChlNC64A_1_25380_e_gw1_15_148_1_RRM_1[KOG0106]rs-Chlamydomonas reinhardtii@jgi_Chlre3_80366_RRM_1
rs-Chlamydomonas reinhardtii@jgi_Chlre3_120019_RRM_1rs-Cyanidioschyzon merolae@gnl_CMER_CMO009C_RRM_1
2rs-Chlorella sp._NC64A@jgi_ChlNC64A_1_25380_e_gw1_15_148_1_RRM_22rs-Cyanidioschyzon merolae@gnl_CMER_CMO009C_RRM_2
2rs-Chlamydomonas reinhardtii@jgi_Chlre3_120019_RRM_2[KOG0106]2rs-Volvox carteri@jgi_Volca1_80657_RRM_1
2rs-Chlamydomonas reinhardtii@jgi_Chlre3_80366_RRM_2[KOG0106]2rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5054582_Sb04g001910_RRM_2
2rs-Oryza sativa_japonica_cultivar_group@NP_001045729_RRM_22rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5056945_Sb06g001100_RRM_2
2rs-Oryza sativa_japonica_cultivar_group@NP_001052061_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_245070_gw1_XIV_1813_1_RRM_2
2rs-Populus trichocarpa@jgi_Poptr1_1_552308_eugene3_00021623_RRM_22rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5030607_Sb01g049590_RRM_2
2rs-Arabidopsis thaliana@NP_567120_RRM_22rs-Arabidopsis thaliana@NP_182184_RRM_22rs-Arabidopsis thaliana@NP_973702_RRM_1
2rs-Arabidopsis thaliana@NP_200017_RRM_22rs-Arabidopsis thaliana@NP_851174_RRM_2
2rs-Arabidopsis thaliana@NP_974616_RRM_1[SR|RSp40/SRp35][KOG0106]2rs-Arabidopsis thaliana@NP_194280_RRM_22rs-Arabidopsis thaliana@NP_001078447_RRM_1
2rs-Physcomitrella patens@jgi_Phypa1_1_167387_RRM_22rs-Selaginella moellendorfii@jgi_Selmo1_82477_e_gw1_5_1267_1_RRM_22rs-Selaginella moellendorfii@jgi_Selmo1_124209_e_gw1_74_375_1_RRM_2
2rs-Populus trichocarpa@jgi_Poptr1_1_244286_gw1_XIV_1029_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_411608_gw1_II_2943_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_253698_gw1_XV_3134_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_423171_gw1_XII_1631_1_RRM_2
ASF-like
"plant"
RRM1
RS
"plant"
RRM2
RS "plant"
Fig. S27
178
67 75
77
50
90 65
100
95
92 72
99 86
91
94 85
69
71
88
59
93
92
58
100
79100
100
92 93
72
100 88
93 62
100
50
81
67
51 97
89
59 56 88
87 62
92 68
99
60
100
99
62 80
62 51
100
100
56
53 64
87
58
100
100
100
96 71
66
88
62
scl-Chlamydomonas reinhardtii@jgi Chlre3 116256 RRM 1scl-Oryza sativa_japonica_cultivar_group@NP_001068546_RRM_1[KOG0127]
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5056881_Sb05g027700_RRM_1scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5047478_Sb0514s002010_RRM_1[KOG0110]scl-Oryza sativa_japonica_cultivar_group@NP_001067091_RRM_1[SR|SCL30b]scl-Oryza sativa_japonica_cultivar_group@NP_001046448_RRM_1[SR|SCL30a]
scl-Arabidopsis thaliana@NP_567021_RRM_1[SR|SCL30][KOG0122]scl-Populus trichocarpa@jgi_Poptr1_1_227475_gw1_X_2172_1_RRM_1[KOG0127]
scl-Populus trichocarpa@jgi_Poptr1_1_656109_grail3_0049021701_RRM_1[KOG0122]scl-Selaginella moellendorfii@jgi_Selmo1_8401_gw1_62_42_1_RRM_1[KOG4207]
scl-Physcomitrella patens@jgi_Phypa1_1_141868_RRM_1scl-Physcomitrella patens@jgi_Phypa1_1_108464_RRM_1
scl-Selaginella moellendorfii@jgi_Selmo1_8339_gw1_49_32_1_RRM_1[KOG4207]scl-Selaginella moellendorfii@jgi_Selmo1_102070_e_gw1_25_62_1_RRM_1[KOG0148]scl-Selaginella moellendorfii@jgi_Selmo1_79810_e_gw1_3_146_1_RRM_1[KOG4207]
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049384_Sb01g034590_RRM_1[KOG0127]scl-Oryza sativa_japonica_cultivar_group@NP_001050168_RRM_1
scl-Populus trichocarpa@jgi_Poptr1_1_814124_estExt_fgenesh4_kg___RRM_1scl-Populus trichocarpa@jgi_Poptr1_1_420699_gw1_VIII_2127_1_RRM_1[SR|SCL28]
scl-Arabidopsis thaliana@NP_197382_RRM_1[SR|SCL28][KOG0127]scl-Populus trichocarpa@jgi_Poptr1_1_547618_eugene3_00010059_RRM_1
scl-Arabidopsis thaliana@NP_187966_RRM_1[SR|SCL30a]scl-Arabidopsis thaliana@NP_564685_RRM_1[SR|SR33/SCL33][KOG0110]scl-Arabidopsis thaliana@NP_001031195_RRM_1[SR|SR33/SCL33][KOG0110]
scl-Populus trichocarpa@jgi_Poptr1_1_256035_gw1_XVI_1974_1_RRM_1[SR|SCL25][KOG0111]scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049360_Sb01g034200_RRM_1
scl-Oryza sativa_japonica_cultivar_group@NP_001050213_RRM_1[KOG4207]scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5052097_Sb02g040350_RRM_1[SR|SCL25]scl-Oryza sativa_japonica_cultivar_group@NP_001060372_RRM_1[SR|SCL25]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5052652_Sb03g005500_RRM_1[KOG0109]rs2z-Oryza sativa_japonica_cultivar_group@NP_001042066_RRM_1[SR|RSZ37a][KOG0109]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045953_Sb09g004723_RRM_1[KOG0109]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045954_Sb09g004726_RRM_1[KOG0107]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045949_Sb09g004685_RRM_1[KOG0106]rs2z-Oryza sativa_japonica_cultivar_group@NP_001054731_RRM_1[SR|RSZ39]
rs2z-Oryza sativa_japonica_cultivar_group@NP_001054489_RRM_1[SR|RSZ36][KOG0109]rs2z-Oryza sativa_japonica_cultivar_group@NP_001049771_RRM_1[SR|RSZ37b][KOG0109]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5060000_Sb09g001920_RRM_1[SR|RSZ36][KOG0106]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5059999_Sb09g001910_RRM_1[SR|RSZ36][KOG0109]
rs2z-Populus trichocarpa@jgi_Poptr1_1_653760_grail3_0013007302_RRM_1[SR|RSZ37b][KOG0107]rs2z-Populus trichocarpa@jgi_Poptr1_1_667717_grail3_0004036801_RRM_1[SR|RSZ37b][KOG0107]
rs2z-Arabidopsis thaliana@NP_190918_RRM_1[SR|RSZ32][KOG0107]rs2z-Arabidopsis thaliana@NP_850280_RRM_1[SR|RSZ33][KOG0107]
srp457-Caenorhabditis elegans@T28D9_2a_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]srp457-Caenorhabditis elegans@T28D9_2d_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]srp457-Caenorhabditis elegans@T28D9_2b_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]
srp457-Homo sapiens@ENSP00000342294_RRM_1[SR|SRp40][KOG0106]srp457-Homo sapiens@ENSP00000377892_RRM_1[SR|SRp40][KOG0105]srp457-Mus musculus@ENSMUSP00000021562_RRM_1[SR|SRp40][KOG0106]srp457-Mus musculus@ENSMUSP00000105985_RRM_1[SR|SRp40][KOG0106]srp457-Mus musculus@ENSMUSP00000105983_RRM_1[SR|SRp40][KOG0106]
srp457-Mus musculus@ENSMUSP00000061474_RRM_1[SR|SRp75][KOG0105]srp457-Homo sapiens@ENSP00000362900_RRM_1[SR|SRp75][KOG0105]
srp457-Mus musculus@ENSMUSP00000017065_RRM_1[SR|SRp55][KOG0105]srp457-Homo sapiens@ENSP00000244020_RRM_1[SR|SRp55][KOG0105]srp457-Homo sapiens@ENSP00000362251_RRM_1[SR|SRp55][KOG0106]
srp457-Caenorhabditis elegans@W02B12_2_RRM_1[SR|CeSRp40/rsp-2][KOG0106]srp457-Caenorhabditis elegans@W02B12_3a_RRM_1[SR|CeSRp75/rsp-1][KOG0106]srp457-Caenorhabditis elegans@W02B12_3c_RRM_1[SR|CeSRp75/rsp-1][KOG0106]srp457-Caenorhabditis elegans@W02B12_3b_RRM_1[SR|CeSRp75/rsp-1][KOG0106]
srp457-Drosophila melanogaster@CG10851_PF_RRM_1[SR|Hrp45][KOG0106]srp457-Drosophila melanogaster@CG10851_PB_RRM_1[SR|SRp55][KOG0106]srp457-Drosophila melanogaster@CG10851_PC_RRM_1[SR|SRp55][KOG0105]srp457-Drosophila melanogaster@CG10851_PE_RRM_1[SR|SRp55][KOG0105]srp457-Drosophila melanogaster@CG10851_PD_RRM_1[SR|Hrp45][KOG0106]
9g8-Drosophila melanogaster@CG5655_PA_RRM_1[KOG0107]srp20-Drosophila melanogaster@CG10203_PA_RRM_1[SR|9G8][KOG0107]
9g8-Drosophila melanogaster@CG1987_PA_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PC_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PD_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PB_RRM_1[KOG0107]
srp20-Mus musculus@ENSMUSP00000100538_RRM_1[SR|SRp20][KOG0107]srp20-Mus musculus@ENSMUSP00000049025_RRM_1[SR|SRp20][KOG0107]srp20-Mus musculus@ENSMUSP00000110365_RRM_1[SR|SRp20][KOG0107]srp20-Homo sapiens@ENSP00000344762_RRM_1[SR|SRp20][KOG0107]srp20-Homo sapiens@ENSP00000362820_RRM_1[SR|SRp20][KOG0107]
9g8-Mus musculus@ENSMUSP00000066393_RRM_1[SR|9G8][KOG0107]9g8-Mus musculus@ENSMUSP00000070983_RRM_1[SR|9G8][KOG0107]9g8-Mus musculus@ENSMUSP00000108040_RRM_1[SR|9G8][KOG0107]9g8-Homo sapiens@ENSP00000368146_RRM_1[SR|9G8][KOG0107]9g8-Homo sapiens@ENSP00000325905_RRM_1[SR|9G8]9g8-Homo sapiens@ENSP00000368134_RRM_1[SR|9G8][KOG0107]
9g8-Caenorhabditis elegans@C33H5_12a_2_RRM_1[SR|CeSRp20/rsp-6][KOG0116]9g8-Caenorhabditis elegans@C33H5_12c_RRM_1[SR|CeSRp20/rsp-6][KOG0107]9g8-Caenorhabditis elegans@C33H5_12b_1_RRM_1[SR|CeSRp20/rsp-6][KOG0107]
rsz-Chlorella sp._NC64A@jgi_ChlNC64A_1_139931_IGS_gm_27_00109_RRM_1[KOG0107]rsz-Chlamydomonas reinhardtii@jgi_Chlre3_132362_RRM_1[KOG0107]
rsz-Volvox carteri@jgi_Volca1_121301_RRM_1[KOG0107]rsz-Chlamydomonas reinhardtii@jgi_Chlre3_192053_RRM_1[KOG0107]
rsz-Chlorella sp._NC64A@jgi_ChlNC64A_1_135849_IGS_gm_14_00382_RRM_1rsz-Populus trichocarpa@jgi_Poptr1_1_248500_gw1_XIX_900_1_RRM_1[SR|SRZ21/RSZ21][KOG0107]
rsz-Populus trichocarpa@jgi_Poptr1_1_261622_gw1_XVIII_2163_1_RRM_1[KOG0116]rsz-Populus trichocarpa@jgi_Poptr1_1_583120_eugene3_01470005_RRM_1[SR|RSZ22a]rsz-Populus trichocarpa@jgi_Poptr1_1_583122_eugene3_01470007_RRM_1[SR|RSZp21a][KOG0107]
rsz-Arabidopsis thaliana@NP_564208_RRM_1[SR|SRZ21/RSZ21]rsz-Arabidopsis thaliana@NP_180035_RRM_1[SR|RSZ22a]
rsz-Arabidopsis thaliana@NP_194886_RRM_1[SR|SRZ22/RSZ22][KOG0107]rsz-Selaginella moellendorfii@jgi_Selmo1_68846_gw1_3_1555_1_RRM_1[KOG0107]rsz-Selaginella moellendorfii@jgi_Selmo1_172361_estExt_Genewise1Plus____RRM_1
rsz-Physcomitrella patens@jgi_Phypa1_1_151194_RRM_1[KOG0107]rsz-Physcomitrella patens@jgi_Phypa1_1_143810_RRM_1[KOG0107]
rsz-Oryza sativa_japonica_cultivar_group@NP_001057018_RRM_1[SR|RSZp21a]rsz-Oryza sativa_japonica_cultivar_group@NP_001047400_RRM_1[SR|RSZp23][KOG0107]
rsz-Sorghum bicolor_BTx623@jgi_Sorbi1_5061430_Sb10g005960_RRM_1[SR|RSZp21a]rsz-Sorghum bicolor_BTx623@jgi_Sorbi1_5056021_Sb04g035540_RRM_1[SR|RSZp21b]
rsz-Oryza sativa_japonica_cultivar_group@NP_001048352_RRM_1[SR|RSZp21b]asflkpl-Chlamydomonas reinhardtii@jgi_Chlre3_120469_RRM_1[KOG0105]
asflkpl-Volvox carteri@jgi_Volca1_72532_RRM_1[KOG0105]asflkan-Caenorhabditis elegans@Y111B2A_18_3_RRM_1[SR|CeSF2/ASF/rsp-3][KOG0105]
asflkpl-Volvox carteri@jgi_Volca1_45192_RRM_1[KOG0105]asflkpl-Chlamydomonas reinhardtii@jgi_Chlre3_129159_RRM_1[KOG0105]
asflkpl-Chlorella sp._NC64A@jgi_ChlNC64A_1_36976_estExt_Genewise1Plus____RRM_1asflkan-Mus musculus@ENSMUSP00000031513_RRM_1[SR|SRp30c][KOG0105]asflkan-Homo sapiens@ENSP00000229390_RRM_1[SR|SRp30c][KOG0105]
asflkan-Drosophila melanogaster@CG6987_PA_RRM_1[KOG0105]asflkan-Mus musculus@ENSMUSP00000103553_RRM_1[SR|ASF/SF2][KOG0105]asflkan-Mus musculus@ENSMUSP00000078792_RRM_1[SR|ASF/SF2][KOG0105]asflkan-Homo sapiens@ENSP00000258962_RRM_1[SR|ASF/SF2][KOG0105]
asflkpl-Oryza sativa_japonica_cultivar_group@NP_001060608_RRM_1[SR|SRp33a][KOG0105]asflkpl Populus trichocarpa@jgi_Poptr1_1_421685_gw1_XII_145_1_RRM_1[SR|SRp34a][KOG0105]
RSZ
"plant"
9G8SRp20
ASF-like
"animal"
SRp40
SRp55
SRp75
RS2Z
"plant"
SCL
N3
N4
N6Fig. S27
179
0.16
83
93100
57
76
100
73
100
98 64
74
83
96
90
82
100
97 77
59
55
66 99
58
94
84
77
68
99
55
57
89
100
62
93
51
100
64
rnps1-Caenorhabditis elegans@K02F3_11_1_RRM_1[KOG4209]rnps1-Drosophila melanogaster@CG16788_PA_RRM_1
rnps1-Drosophila melanogaster@CG41105_PC_RRM_1rnps1-Mus musculus@ENSMUSP00000057332_RRM_1[KOG4209]
rnps1-Mus musculus@ENSMUSP00000111025_RRM_1[RNPS1|RNPS1][KOG4209]rnps1-Mus musculus@ENSMUSP00000111028_RRM_1[RNPS1|RNPS1][KOG4209]rnps1-Homo sapiens@ENSP00000380275_RRM_1[RNPS1|RNPS1][KOG4209]
sr45-Volvox carteri@jgi_Volca1_105177_RRM_1[KOG0462]sr45-Chlorella sp._NC64A@jgi_ChlNC64A_1_138910_IGS_gm_22_00151_RRM_1
sr45-Micromonas pusilla_CCMP1545@jgi_MicpuC2_9037_gw1_7_479_1_RRM_1sr45-Micromonas pusilla_RCC299@jgi_MicpuN3_63440_EuGene_1300010090_RRM_1
sr45-Selaginella moellendorfii@jgi_Selmo1_446044_estExt_fgenesh2_pg____RRM_1sr45-Selaginella moellendorfii@jgi_Selmo1_424875_fgenesh2_pg____RRM_1
sr45-Physcomitrella patens@jgi_Phypa1_1_105411_RRM_1sr45-Physcomitrella patens@jgi_Phypa1_1_166555_RRM_1
sr45-Populus trichocarpa@jgi_Poptr1_1_823076_estExt_fgenesh4_pg___RRM_1sr45-Arabidopsis thaliana@NP_173107_RRM_1[SR|SR45]sr45-Arabidopsis thaliana@NP_973844_RRM_1[SR|SR45]
sr45-Oryza sativa_japonica_cultivar_group@NP_001054414_RRM_1[KOG0117]sr45-Sorghum bicolor_BTx623@jgi_Sorbi1_5054420_Sb03g046480_RRM_1
sr45-Oryza sativa_japonica_cultivar_group@NP_001045458_RRM_1sc35-Ostreococcus lucimarinus@jgi_Ost9901_3_8174_RRM_1[KOG4207]
sc35-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16908_gw1_5_1114_1_RRM_1[KOG4207]sc35-Micromonas pusilla_CCMP1545@jgi_MicpuC2_9129_gw1_3_931_1_RRM_1[KOG4207]
sc35-Micromonas pusilla_RCC299@jgi_MicpuN3_91839_estExt_Genewise2____RRM_1sc35-Drosophila melanogaster@CG5442_PB_RRM_1[SR|SC35][KOG4207]
sc35-Caenorhabditis elegans@EEED8_7b_RRM_1[SR|CeSC35/rsp-4][KOG4207]sc35-Caenorhabditis elegans@EEED8_7a_RRM_1[SR|CeSC35/rsp-4]
sc35-Mus musculus@ENSMUSP00000078984_RRM_1[KOG4207]sc35-Homo sapiens@ENSP00000381889_RRM_1[KOG4207]
sc35-Mus musculus@ENSMUSP00000072182_RRM_1[SR|SC35][KOG4207]sc35-Homo sapiens@ENSP00000293233_RRM_1[SR|SC35][KOG4368]sc35-Mus musculus@ENSMUSP00000090059_RRM_1[SR|SC35][KOG4368]sc35-Homo sapiens@ENSP00000353089_RRM_1[SR|SC35][KOG4368]
scl-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16959_gw1_4_1177_1_RRM_1[KOG0108]scl-Ostreococcus lucimarinus@jgi_Ost9901_3_9858_RRM_1[KOG0108]
scl-Ostreococcus tauri@jgi_Ostta4_7793_RRM_1[KOG0108]sc35-Cyanidioschyzon merolae@gnl_CMER_CML202C_RRM_1
sc35-Oryza sativa_japonica_cultivar_group@NP_001060322_RRM_1[SR|SC35b][KOG4207]sc35-Sorghum bicolor_BTx623@jgi_Sorbi1_5029845_Sb01g033710_RRM_1[KOG4207]
sc35-Oryza sativa_japonica_cultivar_group@NP_001050263_RRM_1[SR|SC35c][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_709848_estExt_Genewise1___RRM_1[KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_559112_eugene3_00050727_RRM_1[SR|SC35a][KOG4207]
sc35-Arabidopsis thaliana@NP_851261_RRM_1[SR|SC35][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_672394_grail3_1445000102_RRM_1[SR|SC35a][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_645719_grail3_0067008905_RRM_1[SR|SC35b][KOG4207]
sc35-Selaginella moellendorfii@jgi_Selmo1_134332_e_gw1_124_43_1_RRM_1[SR|SC35a][KOG4207]sc35-Sorghum bicolor_BTx623@jgi_Sorbi1_5059167_Sb07g029000_RRM_1[KOG0147]
sc35-Oryza sativa_japonica_cultivar_group@NP_001062094_RRM_1[SR|SC35a][KOG0415]sc35-Selaginella moellendorfii@jgi_Selmo1_7952_gw1_7_122_1_RRM_1[SR|SC35a][KOG4207]
sc35-Physcomitrella patens@jgi_Phypa1_1_122960_RRM_1[KOG4207]sc35-Physcomitrella patens@jgi_Phypa1_1_172957_RRM_1[KOG0415]
scl-Micromonas pusilla_CCMP1545@jgi_MicpuC2_11901_gw1_8_619_1_RRM_1[KOG4207]scl-Micromonas pusilla_RCC299@jgi_MicpuN3_74643_gw2_11_587_1_RRM_1[KOG0107]
scl-Chlorella sp._NC64A@jgi_ChlNC64A_1_135593_IGS_gm_14_00126_RRM_1[KOG4207]srrp-Mus musculus@ENSMUSP00000103794_RRM_1[SRrp|SRrp35][KOG0111]
srrp-Homo sapiens@ENSP00000358479_RRM_1[SRrp|SRrp35]srrp-Mus musculus@ENSMUSP00000095455_RRM_1[SRrp|SRp38]srrp-Mus musculus@ENSMUSP00000030437_RRM_1[SRrp|SRp38][KOG0415]srrp-Mus musculus@ENSMUSP00000101479_RRM_1[SRrp|SRp38][KOG0415]srrp-Mus musculus@ENSMUSP00000099603_RRM_1[SRrp|SRp38][KOG0111]srrp-Mus musculus@ENSMUSP00000030438_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000342913_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000340764_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000363577_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000363576_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000363573_RRM_1[SRrp|SRp38][KOG0415]srrp-Homo sapiens@ENSP00000345293_RRM_1[SRrp|SRp38]
scl-Chlorella sp._NC64A@jgi_ChlNC64A_1_17896_gw1_13_295_1_RRM_1scl-Volvox carteri@jgi_Volca1_120666_RRM_1scl-Chlamydomonas reinhardtii@jgi_Chlre3_188086_RRM_1
scl-Volvox carteri@jgi_Volca1_73973_RRM_1[KOG4207]scl-Chlamydomonas reinhardtii@jgi_Chlre3_113900_RRM_1[KOG4207]
scl-Volvox carteri@jgi_Volca1_121229_RRM_1[KOG0415]scl Chlamydomonas reinhardtii@jgi_Chlre3_116256_RRM_1
SRrp
SC35
RNPS1
SR45
N1
N2
Fig. S27
180
95
100
100
100 84
97
95
79
95
100 62
94
92 88
99 86
100
95
100
100
99
100 74
64
100
100 62
78
69
93
100 92
60
srp457-Homo sapiens@ENSP00000362251 RRM 1[SR|SRp55][KOG0106]srp457-Homo sapiens@ENSP00000244020_RRM_1[SR|SRp55][KOG0105]
srp457-Drosophila melanogaster@CG10851_PE_RRM_1[SR|SRp55][KOG0105]srp457-Drosophila melanogaster@CG10851_PC_RRM_1[SR|SRp55][KOG0105]srp457-Drosophila melanogaster@CG10851_PF_RRM_1[SR|Hrp45][KOG0106]srp457-Drosophila melanogaster@CG10851_PD_RRM_1[SR|Hrp45][KOG0106]srp457-Drosophila melanogaster@CG10851_PB_RRM_1[SR|SRp55][KOG0106]
srp457-Caenorhabditis elegans@T28D9_2b_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]srp457-Caenorhabditis elegans@T28D9_2a_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]srp457-Caenorhabditis elegans@T28D9_2d_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]
srp457-Caenorhabditis elegans@W02B12_2_RRM_1[SR|CeSRp40/rsp-2][KOG0106]srp457-Caenorhabditis elegans@W02B12_3c_RRM_1[SR|CeSRp75/rsp-1][KOG0106]srp457-Caenorhabditis elegans@W02B12_3b_RRM_1[SR|CeSRp75/rsp-1][KOG0106]srp457-Caenorhabditis elegans@W02B12_3a_RRM_1[SR|CeSRp75/rsp-1][KOG0106]
asflkpl-Ostreococcus lucimarinus@jgi_Ost9901_3_8794_RRM_1[KOG0105]asflkpl-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16551_gw1_5_1077_1_RRM_1[KOG0105]
rs-Chlorella sp._NC64A@jgi_ChlNC64A_1_25380_e_gw1_15_148_1_RRM_1[KOG0106]rs-Cyanidioschyzon merolae@gnl_CMER_CMO009C_RRM_1
rs-Chlamydomonas reinhardtii@jgi_Chlre3_120019_RRM_1rs-Chlamydomonas reinhardtii@jgi_Chlre3_80366_RRM_1
rs-Populus trichocarpa@jgi_Poptr1_1_245070_gw1_XIV_1813_1_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_552308_eugene3_00021623_RRM_1[KOG0106]
rs-Oryza sativa_japonica_cultivar_group@NP_001052061_RRM_1[SR|RSp29][KOG0106]rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5056945_Sb06g001100_RRM_1[SR|RSp29][KOG0106]
rs-Arabidopsis thaliana@NP_567120_RRM_1[SR|RSp31][KOG0106]rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5030607_Sb01g049590_RRM_1[KOG0106]
rs-Arabidopsis thaliana@NP_182184_RRM_1[SR|RSp31a][KOG0106]rs-Physcomitrella patens@jgi_Phypa1_1_167387_RRM_1[KOG0106]
rs-Selaginella moellendorfii@jgi_Selmo1_124209_e_gw1_74_375_1_RRM_1[KOG0106]rs-Selaginella moellendorfii@jgi_Selmo1_82477_e_gw1_5_1267_1_RRM_1[KOG0106]
rs-Populus trichocarpa@jgi_Poptr1_1_423171_gw1_XII_1631_1_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_253698_gw1_XV_3134_1_RRM_1[KOG0106]
rs-Arabidopsis thaliana@NP_194280_RRM_1[SR|RSp40/SRp35][KOG0106]rs-Arabidopsis thaliana@NP_200017_RRM_1[SR|RSp41][KOG0106]rs-Arabidopsis thaliana@NP_851174_RRM_1[SR|RSp41][KOG0106]
rs-Oryza sativa_japonica_cultivar_group@NP_001045729_RRM_1[SR|RSp33][KOG0106]rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5054582_Sb04g001910_RRM_1[KOG0106]
rs-Populus trichocarpa@jgi_Poptr1_1_244286_gw1_XIV_1029_1_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_411608_gw1_II_2943_1_RRM_1[SR|RSp33][KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_644386_grail3_0033034501_RRM_1[SR|RSp33][KOG0106]
asflkpl-Volvox carteri@jgi_Volca1_72532_RRM_1[KOG0105]asflkpl-Chlamydomonas reinhardtii@jgi_Chlre3_120469_RRM_1[KOG0105]
asflkan-Caenorhabditis elegans@Y111B2A_18_3_RRM_1[SR|CeSF2/ASF/rsp-3][KOG0105]asflkpl-Chlamydomonas reinhardtii@jgi_Chlre3_129159_RRM_1[KOG0105]
asflkpl-Volvox carteri@jgi_Volca1_45192_RRM_1[KOG0105]asflkpl-Chlorella sp._NC64A@jgi_ChlNC64A_1_36976_estExt_Genewise1Plus____RRM_1
asflkpl-Oryza sativa_japonica_cultivar_group@NP_001060608_RRM_1[SR|SRp33a][KOG0105]asflkpl-Selaginella moellendorfii@jgi_Selmo1_97566_e_gw1_19_485_1_RRM_1[KOG0105]asflkpl-Selaginella moellendorfii@jgi_Selmo1_119951_e_gw1_61_278_1_RRM_1[KOG0105]
asflkpl-Sorghum bicolor_BTx623@jgi_Sorbi1_5035702_Sb03g013010_RRM_1[SR|SR20][KOG0105]asflkpl-Oryza sativa_japonica_cultivar_group@NP_001055323_RRM_1[SR|SRp33b][KOG0105]
asflkpl-Arabidopsis thaliana@NP_683288_RRM_1[SR|SRp30][KOG0105]asflkpl-Arabidopsis thaliana@NP_172386_RRM_1[SR|SRp30][KOG0105]
asflkan-Homo sapiens@ENSP00000229390_RRM_1[SR|SRp30c][KOG0105]asflkan-Mus musculus@ENSMUSP00000031513_RRM_1[SR|SRp30c][KOG0105]
asflkan-Drosophila melanogaster@CG6987_PA_RRM_1[KOG0105]asflkan-Mus musculus@ENSMUSP00000103553_RRM_1[SR|ASF/SF2][KOG0105]asflkan-Mus musculus@ENSMUSP00000078792_RRM_1[SR|ASF/SF2][KOG0105]asflkan-Homo sapiens@ENSP00000258962_RRM_1[SR|ASF/SF2][KOG0105]
asflkpl-Arabidopsis thaliana@NP_849537_RRM_1[SR|SRp34b][KOG0105]asflkpl-Arabidopsis thaliana@NP_567235_RRM_1[SR|SRp34b][KOG0105]
asflkpl-Arabidopsis thaliana@NP_850934_RRM_1[SR|SR1/SRp34][KOG0105]asflkpl-Arabidopsis thaliana@NP_850933_RRM_1[SR|SR1/SRp34][KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_409414_gw1_II_749_1_RRM_1[KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_664446_grail3_0061020502_RRM_1[SR|SRp33a][KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_773626_fgenesh4_pg___RRM_1[SR|SRp30][KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_811208_fgenesh4_pm____RRM_1
asflkpl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049442_Sb01g035680_RRM_1[SR|SRp32][KOG0105]asflkpl-Oryza sativa_japonica_cultivar_group@NP_001050082_RRM_1[SR|SRp32][KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_250704_gw1_XV_140_1_RRM_1[SR|SRp34a][KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_421685_gw1_XII_145_1_RRM_1[SR|SRp34a][KOG0105]
asflkpl-Arabidopsis thaliana@NP_190512_RRM_1[SR|SRp34a][KOG0105]asflkpl-Arabidopsis thaliana@NP_001078264_RRM_1[SR|SRp34a][KOG0105]
asflkpl-Selaginella moellendorfii@jgi_Selmo1_36388_gw1_41_236_1_RRM_1[KOG0105]asflkpl-Physcomitrella patens@jgi_Phypa1_1_205547_RRM_1[KOG0105]
asflkpl-Physcomitrella patens@jgi_Phypa1_1_113630_RRM_1[KOG0105]asflkpl-Physcomitrella patens@jgi_Phypa1_1_140978_RRM_1[KOG0105]
ASF-like
"plant"ASF-like
"animal"
RRM1
RS "plant"
SRp40
SRp55
SRp75
N5
N6
Fig. S28
181
67 83
73
100
67
52
91
61
55 52
57
71
81
98
100
95 69 52
55
68
86
96
97
100100
90
73
71 67
99
88 70
100
90
87 84
100 88
57
64
100
75
62
87
52 83
100
100
95 86
67 55
srp20-Drosophila melanogaster@CG10203 PA RRM 1[SR|9G8][KOG0107]srp20-Mus musculus@ENSMUSP00000100538_RRM_1[SR|SRp20][KOG0107]
srp20-Mus musculus@ENSMUSP00000049025_RRM_1[SR|SRp20][KOG0107]srp20-Homo sapiens@ENSP00000344762_RRM_1[SR|SRp20][KOG0107]srp20-Homo sapiens@ENSP00000362820_RRM_1[SR|SRp20][KOG0107]srp20-Mus musculus@ENSMUSP00000110365_RRM_1[SR|SRp20][KOG0107]
9g8-Mus musculus@ENSMUSP00000070983_RRM_1[SR|9G8][KOG0107]9g8-Mus musculus@ENSMUSP00000108040_RRM_1[SR|9G8][KOG0107]9g8-Homo sapiens@ENSP00000325905_RRM_1[SR|9G8]9g8-Homo sapiens@ENSP00000368134_RRM_1[SR|9G8][KOG0107]9g8-Homo sapiens@ENSP00000368146_RRM_1[SR|9G8][KOG0107]9g8-Mus musculus@ENSMUSP00000066393_RRM_1[SR|9G8][KOG0107]
scl-Micromonas pusilla_RCC299@jgi_MicpuN3_74643_gw2_11_587_1_RRM_1[KOG0107]scl-Micromonas pusilla_CCMP1545@jgi_MicpuC2_11901_gw1_8_619_1_RRM_1[KOG4207]
sc35-Cyanidioschyzon merolae@gnl_CMER_CML202C_RRM_1sc35-Oryza sativa_japonica_cultivar_group@NP_001060322_RRM_1[SR|SC35b][KOG4207]
sc35-Populus trichocarpa@jgi_Poptr1_1_559112_eugene3_00050727_RRM_1[SR|SC35a][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_709848_estExt_Genewise1___RRM_1[KOG4207]
sc35-Arabidopsis thaliana@NP_851261_RRM_1[SR|SC35][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_645719_grail3_0067008905_RRM_1[SR|SC35b][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_672394_grail3_1445000102_RRM_1[SR|SC35a][KOG4207]
sc35-Oryza sativa_japonica_cultivar_group@NP_001062094_RRM_1[SR|SC35a][KOG0415]sc35-Sorghum bicolor_BTx623@jgi_Sorbi1_5029845_Sb01g033710_RRM_1[KOG4207]
sc35-Oryza sativa_japonica_cultivar_group@NP_001050263_RRM_1[SR|SC35c][KOG4207]sc35-Sorghum bicolor_BTx623@jgi_Sorbi1_5059167_Sb07g029000_RRM_1[KOG0147]
sc35-Selaginella moellendorfii@jgi_Selmo1_134332_e_gw1_124_43_1_RRM_1[SR|SC35a][KOG4207]sc35-Selaginella moellendorfii@jgi_Selmo1_7952_gw1_7_122_1_RRM_1[SR|SC35a][KOG4207]
sc35-Physcomitrella patens@jgi_Phypa1_1_122960_RRM_1[KOG4207]sc35-Physcomitrella patens@jgi_Phypa1_1_172957_RRM_1[KOG0415]
sc35-Micromonas pusilla_CCMP1545@jgi_MicpuC2_9129_gw1_3_931_1_RRM_1[KOG4207]sc35-Micromonas pusilla_RCC299@jgi_MicpuN3_91839_estExt_Genewise2____RRM_1
sc35-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16908_gw1_5_1114_1_RRM_1[KOG4207]sc35-Ostreococcus lucimarinus@jgi_Ost9901_3_8174_RRM_1[KOG4207]
scl-Ostreococcus tauri@jgi_Ostta4_7793_RRM_1[KOG0108]scl-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16959_gw1_4_1177_1_RRM_1[KOG0108]
scl-Ostreococcus lucimarinus@jgi_Ost9901_3_9858_RRM_1[KOG0108]sc35-Drosophila melanogaster@CG5442_PB_RRM_1[SR|SC35][KOG4207]
sc35-Caenorhabditis elegans@EEED8_7b_RRM_1[SR|CeSC35/rsp-4][KOG4207]sc35-Caenorhabditis elegans@EEED8_7a_RRM_1[SR|CeSC35/rsp-4]
sc35-Mus musculus@ENSMUSP00000078984_RRM_1[KOG4207]sc35-Homo sapiens@ENSP00000381889_RRM_1[KOG4207]
sc35-Mus musculus@ENSMUSP00000090059_RRM_1[SR|SC35][KOG4368]sc35-Homo sapiens@ENSP00000353089_RRM_1[SR|SC35][KOG4368]sc35-Homo sapiens@ENSP00000293233_RRM_1[SR|SC35][KOG4368]sc35-Mus musculus@ENSMUSP00000072182_RRM_1[SR|SC35][KOG4207]
scl-Chlamydomonas reinhardtii@jgi_Chlre3_188086_RRM_1scl-Volvox carteri@jgi_Volca1_120666_RRM_1
scl-Volvox carteri@jgi_Volca1_73973_RRM_1[KOG4207]scl-Chlamydomonas reinhardtii@jgi_Chlre3_113900_RRM_1[KOG4207]
scl-Chlorella sp._NC64A@jgi_ChlNC64A_1_135593_IGS_gm_14_00126_RRM_1[KOG4207]scl-Volvox carteri@jgi_Volca1_121229_RRM_1[KOG0415]scl-Chlamydomonas reinhardtii@jgi_Chlre3_116256_RRM_1scl-Chlorella sp._NC64A@jgi_ChlNC64A_1_17896_gw1_13_295_1_RRM_1
srrp-Mus musculus@ENSMUSP00000103794_RRM_1[SRrp|SRrp35][KOG0111]srrp-Homo sapiens@ENSP00000358479_RRM_1[SRrp|SRrp35]
srrp-Mus musculus@ENSMUSP00000101479_RRM_1[SRrp|SRp38][KOG0415]srrp-Homo sapiens@ENSP00000363573_RRM_1[SRrp|SRp38][KOG0415]srrp-Homo sapiens@ENSP00000342913_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000345293_RRM_1[SRrp|SRp38]srrp-Mus musculus@ENSMUSP00000095455_RRM_1[SRrp|SRp38]srrp-Homo sapiens@ENSP00000340764_RRM_1[SRrp|SRp38][KOG0111]srrp-Mus musculus@ENSMUSP00000099603_RRM_1[SRrp|SRp38][KOG0111]srrp-Mus musculus@ENSMUSP00000030437_RRM_1[SRrp|SRp38][KOG0415]srrp-Mus musculus@ENSMUSP00000030438_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000363577_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000363576_RRM_1[SRrp|SRp38][KOG0111]
scl-Selaginella moellendorfii@jgi_Selmo1_8401_gw1_62_42_1_RRM_1[KOG4207]scl-Physcomitrella patens@jgi_Phypa1_1_141868_RRM_1scl-Physcomitrella patens@jgi_Phypa1_1_108464_RRM_1
scl-Populus trichocarpa@jgi_Poptr1_1_227475_gw1_X_2172_1_RRM_1[KOG0127]scl-Populus trichocarpa@jgi_Poptr1_1_656109_grail3_0049021701_RRM_1[KOG0122]
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5047478_Sb0514s002010_RRM_1[KOG0110]scl-Oryza sativa_japonica_cultivar_group@NP_001046448_RRM_1[SR|SCL30a]scl-Oryza sativa_japonica_cultivar_group@NP_001067091_RRM_1[SR|SCL30b]
scl-Arabidopsis thaliana@NP_567021_RRM_1[SR|SCL30][KOG0122]scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5056881_Sb05g027700_RRM_1
scl-Oryza sativa_japonica_cultivar_group@NP_001068546_RRM_1[KOG0127]scl-Selaginella moellendorfii@jgi_Selmo1_8339_gw1_49_32_1_RRM_1[KOG4207]
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049384_Sb01g034590_RRM_1[KOG0127]scl-Oryza sativa_japonica_cultivar_group@NP_001050168_RRM_1
scl-Populus trichocarpa@jgi_Poptr1_1_814124_estExt_fgenesh4_kg___RRM_1scl-Populus trichocarpa@jgi_Poptr1_1_420699_gw1_VIII_2127_1_RRM_1[SR|SCL28]
scl-Arabidopsis thaliana@NP_197382_RRM_1[SR|SCL28][KOG0127]scl-Selaginella moellendorfii@jgi_Selmo1_102070_e_gw1_25_62_1_RRM_1[KOG0148]scl-Selaginella moellendorfii@jgi_Selmo1_79810_e_gw1_3_146_1_RRM_1[KOG4207]
scl-Populus trichocarpa@jgi_Poptr1_1_256035_gw1_XVI_1974_1_RRM_1[SR|SCL25][KOG0111]scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5052097_Sb02g040350_RRM_1[SR|SCL25]scl-Oryza sativa_japonica_cultivar_group@NP_001060372_RRM_1[SR|SCL25]
scl-Oryza sativa_japonica_cultivar_group@NP_001050213_RRM_1[KOG4207]scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049360_Sb01g034200_RRM_1
scl-Populus trichocarpa@jgi_Poptr1_1_547618_eugene3_00010059_RRM_1scl-Arabidopsis thaliana@NP_187966_RRM_1[SR|SCL30a]scl-Arabidopsis thaliana@NP_001031195_RRM_1[SR|SR33/SCL33][KOG0110]scl-Arabidopsis thaliana@NP_564685_RRM_1[SR|SR33/SCL33][KOG0110]
9g8-Caenorhabditis elegans@C33H5_12c_RRM_1[SR|CeSRp20/rsp-6][KOG0107]9g8-Caenorhabditis elegans@C33H5_12b_1_RRM_1[SR|CeSRp20/rsp-6][KOG0107]9g8-Caenorhabditis elegans@C33H5_12a_2_RRM_1[SR|CeSRp20/rsp-6][KOG0116]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045953_Sb09g004723_RRM_1[KOG0109]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045954_Sb09g004726_RRM_1[KOG0107]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045949_Sb09g004685_RRM_1[KOG0106]rs2z-Oryza sativa_japonica_cultivar_group@NP_001054731_RRM_1[SR|RSZ39]
rs2z-Populus trichocarpa@jgi_Poptr1_1_667717_grail3_0004036801_RRM_1[SR|RSZ37b][KOG0107]rs2z-Populus trichocarpa@jgi_Poptr1_1_653760_grail3_0013007302_RRM_1[SR|RSZ37b][KOG0107]rs2z-Arabidopsis thaliana@NP_190918_RRM_1[SR|RSZ32][KOG0107]
rs2z-Arabidopsis thaliana@NP_850280_RRM_1[SR|RSZ33][KOG0107]rs2z-Oryza sativa_japonica_cultivar_group@NP_001042066_RRM_1[SR|RSZ37a][KOG0109]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5052652_Sb03g005500_RRM_1[KOG0109]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5059999_Sb09g001910_RRM_1[SR|RSZ36][KOG0109]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5060000_Sb09g001920_RRM_1[SR|RSZ36][KOG0106]
rs2z-Oryza sativa_japonica_cultivar_group@NP_001054489_RRM_1[SR|RSZ36][KOG0109]rs2z-Oryza sativa_japonica_cultivar_group@NP_001049771_RRM_1[SR|RSZ37b][KOG0109]
srp457-Mus musculus@ENSMUSP00000105983_RRM_1[SR|SRp40][KOG0106]srp457-Mus musculus@ENSMUSP00000021562_RRM_1[SR|SRp40][KOG0106]srp457-Homo sapiens@ENSP00000377892_RRM_1[SR|SRp40][KOG0105]srp457-Mus musculus@ENSMUSP00000105985_RRM_1[SR|SRp40][KOG0106]srp457-Homo sapiens@ENSP00000342294_RRM_1[SR|SRp40][KOG0106]
srp457-Homo sapiens@ENSP00000362900_RRM_1[SR|SRp75][KOG0105]srp457-Mus musculus@ENSMUSP00000061474_RRM_1[SR|SRp75][KOG0105]
srp457-Mus musculus@ENSMUSP00000017065_RRM_1[SR|SRp55][KOG0105]p p _ _ [ p ][ ] SRp75
RS2Z
"plant"
SCL
SRrp
SC35
9G8SRp20
N1
N2
Fig. S28
182
0.17
71
99 94
52
63
100
72
100
94 87
52
85
78
82 50
100 60
98
95
97 98
93
89
100
100
64
77
100 53
100
100
57
54
58
56 82
74
62
100 85
sr45-Volvox carteri@jgi_Volca1_105177_RRM_1[KOG0462]rnps1-Caenorhabditis elegans@K02F3_11_1_RRM_1[KOG4209]
rnps1-Drosophila melanogaster@CG41105_PC_RRM_1rnps1-Drosophila melanogaster@CG16788_PA_RRM_1rnps1-Mus musculus@ENSMUSP00000057332_RRM_1[KOG4209]
rnps1-Homo sapiens@ENSP00000380275_RRM_1[RNPS1|RNPS1][KOG4209]rnps1-Mus musculus@ENSMUSP00000111025_RRM_1[RNPS1|RNPS1][KOG4209]rnps1-Mus musculus@ENSMUSP00000111028_RRM_1[RNPS1|RNPS1][KOG4209]
sr45-Chlorella sp._NC64A@jgi_ChlNC64A_1_138910_IGS_gm_22_00151_RRM_1sr45-Micromonas pusilla_CCMP1545@jgi_MicpuC2_9037_gw1_7_479_1_RRM_1
sr45-Micromonas pusilla_RCC299@jgi_MicpuN3_63440_EuGene_1300010090_RRM_1sr45-Selaginella moellendorfii@jgi_Selmo1_424875_fgenesh2_pg____RRM_1sr45-Selaginella moellendorfii@jgi_Selmo1_446044_estExt_fgenesh2_pg____RRM_1
sr45-Physcomitrella patens@jgi_Phypa1_1_166555_RRM_1sr45-Physcomitrella patens@jgi_Phypa1_1_105411_RRM_1
sr45-Populus trichocarpa@jgi_Poptr1_1_823076_estExt_fgenesh4_pg___RRM_1sr45-Arabidopsis thaliana@NP_973844_RRM_1[SR|SR45]sr45-Arabidopsis thaliana@NP_173107_RRM_1[SR|SR45]
sr45-Oryza sativa_japonica_cultivar_group@NP_001054414_RRM_1[KOG0117]sr45-Sorghum bicolor_BTx623@jgi_Sorbi1_5054420_Sb03g046480_RRM_1
sr45-Oryza sativa_japonica_cultivar_group@NP_001045458_RRM_12rs-Cyanidioschyzon merolae@gnl_CMER_CMO009C_RRM_2
2rs-Chlorella sp._NC64A@jgi_ChlNC64A_1_25380_e_gw1_15_148_1_RRM_22rs-Chlamydomonas reinhardtii@jgi_Chlre3_120019_RRM_2[KOG0106]
2rs-Volvox carteri@jgi_Volca1_80657_RRM_12rs-Chlamydomonas reinhardtii@jgi_Chlre3_80366_RRM_2[KOG0106]
2rs-Physcomitrella patens@jgi_Phypa1_1_167387_RRM_22rs-Selaginella moellendorfii@jgi_Selmo1_124209_e_gw1_74_375_1_RRM_22rs-Selaginella moellendorfii@jgi_Selmo1_82477_e_gw1_5_1267_1_RRM_2
2rs-Populus trichocarpa@jgi_Poptr1_1_423171_gw1_XII_1631_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_253698_gw1_XV_3134_1_RRM_22rs-Arabidopsis thaliana@NP_200017_RRM_22rs-Arabidopsis thaliana@NP_851174_RRM_2
2rs-Arabidopsis thaliana@NP_974616_RRM_1[SR|RSp40/SRp35][KOG0106]2rs-Arabidopsis thaliana@NP_194280_RRM_22rs-Arabidopsis thaliana@NP_001078447_RRM_1
2rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5054582_Sb04g001910_RRM_22rs-Oryza sativa_japonica_cultivar_group@NP_001045729_RRM_2
2rs-Populus trichocarpa@jgi_Poptr1_1_411608_gw1_II_2943_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_244286_gw1_XIV_1029_1_RRM_2
2rs-Oryza sativa_japonica_cultivar_group@NP_001052061_RRM_22rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5056945_Sb06g001100_RRM_2
2rs-Populus trichocarpa@jgi_Poptr1_1_245070_gw1_XIV_1813_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_552308_eugene3_00021623_RRM_2
2rs-Arabidopsis thaliana@NP_973702_RRM_12rs-Arabidopsis thaliana@NP_182184_RRM_22rs-Arabidopsis thaliana@NP_567120_RRM_2
2rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5030607_Sb01g049590_RRM_29g8-Drosophila melanogaster@CG5655_PA_RRM_1[KOG0107]
rsz-Chlorella sp._NC64A@jgi_ChlNC64A_1_135849_IGS_gm_14_00382_RRM_1rsz-Chlamydomonas reinhardtii@jgi_Chlre3_132362_RRM_1[KOG0107]
rsz-Volvox carteri@jgi_Volca1_121301_RRM_1[KOG0107]rsz-Chlamydomonas reinhardtii@jgi_Chlre3_192053_RRM_1[KOG0107]
rsz-Chlorella sp._NC64A@jgi_ChlNC64A_1_139931_IGS_gm_27_00109_RRM_1[KOG0107]rsz-Selaginella moellendorfii@jgi_Selmo1_68846_gw1_3_1555_1_RRM_1[KOG0107]rsz-Selaginella moellendorfii@jgi_Selmo1_172361_estExt_Genewise1Plus____RRM_1
rsz-Physcomitrella patens@jgi_Phypa1_1_151194_RRM_1[KOG0107]rsz-Physcomitrella patens@jgi_Phypa1_1_143810_RRM_1[KOG0107]
rsz-Arabidopsis thaliana@NP_564208_RRM_1[SR|SRZ21/RSZ21]rsz-Populus trichocarpa@jgi_Poptr1_1_248500_gw1_XIX_900_1_RRM_1[SR|SRZ21/RSZ21][KOG0107]
rsz-Oryza sativa_japonica_cultivar_group@NP_001057018_RRM_1[SR|RSZp21a]rsz-Oryza sativa_japonica_cultivar_group@NP_001047400_RRM_1[SR|RSZp23][KOG0107]
rsz-Sorghum bicolor_BTx623@jgi_Sorbi1_5061430_Sb10g005960_RRM_1[SR|RSZp21a]rsz-Sorghum bicolor_BTx623@jgi_Sorbi1_5056021_Sb04g035540_RRM_1[SR|RSZp21b]
rsz-Oryza sativa_japonica_cultivar_group@NP_001048352_RRM_1[SR|RSZp21b]rsz-Arabidopsis thaliana@NP_180035_RRM_1[SR|RSZ22a]rsz-Arabidopsis thaliana@NP_194886_RRM_1[SR|SRZ22/RSZ22][KOG0107]
rsz-Populus trichocarpa@jgi_Poptr1_1_261622_gw1_XVIII_2163_1_RRM_1[KOG0116]rsz-Populus trichocarpa@jgi_Poptr1_1_583120_eugene3_01470005_RRM_1[SR|RSZ22a]rsz-Populus trichocarpa@jgi_Poptr1_1_583122_eugene3_01470007_RRM_1[SR|RSZp21a][KOG0107]
9g8-Drosophila melanogaster@CG1987_PA_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PC_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PB_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PD_RRM_1[KOG0107]
p p g _ _ _ [ ][ ]
RSZ
"plant"
RRM2
RS
"plant"
SR45
RNPS1
N4Fig. S28
183
8894
99
70 96
100
70 68
60
100
100100
62
99
71
96 95
98
92 88
99
100 86
95 58
57
99
60
99
99
100
64
82
94
90
94 57
100
99 99
52
66
88
53
52
62
68
56
99
58
75
asflkpl-Arabidopsis thaliana@NP_850934_RRM_1[SR|SR1/SRp34][KOG0105]asflkpl-Arabidopsis thaliana@NP_567235_RRM_1[SR|SRp34b][KOG0105]asflkpl-Arabidopsis thaliana@NP_849537_RRM_1[SR|SRp34b][KOG0105]
asflkpl-Oryza sativa_japonica_cultivar_group@NP_001050082_RRM_1[SR|SRp32][KOG0105]asflkpl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049442_Sb01g035680_RRM_1[SR|SRp32][KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_664446_grail3_0061020502_RRM_1[SR|SRp33a][KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_409414_gw1_II_749_1_RRM_1[KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_773626_fgenesh4_pg___RRM_1[SR|SRp30][KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_811208_fgenesh4_pm____RRM_1
asflkpl-Volvox carteri@jgi_Volca1_72532_RRM_1[KOG0105]asflkpl-Chlamydomonas reinhardtii@jgi_Chlre3_120469_RRM_1[KOG0105]
asflkpl-Selaginella moellendorfii@jgi_Selmo1_119951_e_gw1_61_278_1_RRM_1[KOG0105]asflkpl-Selaginella moellendorfii@jgi_Selmo1_97566_e_gw1_19_485_1_RRM_1[KOG0105]
asflkpl-Physcomitrella patens@jgi_Phypa1_1_113630_RRM_1[KOG0105]asflkpl-Physcomitrella patens@jgi_Phypa1_1_140978_RRM_1[KOG0105]asflkpl-Physcomitrella patens@jgi_Phypa1_1_205547_RRM_1[KOG0105]
asflkpl-Selaginella moellendorfii@jgi_Selmo1_36388_gw1_41_236_1_RRM_1[KOG0105]asflkpl-Arabidopsis thaliana@NP_001078264_RRM_1[SR|SRp34a][KOG0105]asflkpl-Arabidopsis thaliana@NP_190512_RRM_1[SR|SRp34a][KOG0105]
asflkpl-Populus trichocarpa@jgi_Poptr1_1_250704_gw1_XV_140_1_RRM_1[SR|SRp34a][KOG0105]asflkpl-Populus trichocarpa@jgi_Poptr1_1_421685_gw1_XII_145_1_RRM_1[SR|SRp34a][KOG0105]
asflkan-Caenorhabditis elegans@Y111B2A_18_3_RRM_1[SR|CeSF2/ASF/rsp-3][KOG0105]asflkpl-Ostreococcus lucimarinus@jgi_Ost9901_3_8794_RRM_1[KOG0105]asflkpl-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16551_gw1_5_1077_1_RRM_1[KOG0105]
asflkpl-Chlamydomonas reinhardtii@jgi_Chlre3_129159_RRM_1[KOG0105]asflkpl-Volvox carteri@jgi_Volca1_45192_RRM_1[KOG0105]
rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5054582_Sb04g001910_RRM_1[KOG0106]rs-Oryza sativa_japonica_cultivar_group@NP_001045729_RRM_1[SR|RSp33][KOG0106]
rs-Populus trichocarpa@jgi_Poptr1_1_244286_gw1_XIV_1029_1_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_411608_gw1_II_2943_1_RRM_1[SR|RSp33][KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_644386_grail3_0033034501_RRM_1[SR|RSp33][KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_253698_gw1_XV_3134_1_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_423171_gw1_XII_1631_1_RRM_1[KOG0106]rs-Arabidopsis thaliana@NP_194280_RRM_1[SR|RSp40/SRp35][KOG0106]rs-Arabidopsis thaliana@NP_200017_RRM_1[SR|RSp41][KOG0106]rs-Arabidopsis thaliana@NP_851174_RRM_1[SR|RSp41][KOG0106]
rs-Cyanidioschyzon merolae@gnl_CMER_CMO009C_RRM_1rs-Chlorella sp._NC64A@jgi_ChlNC64A_1_25380_e_gw1_15_148_1_RRM_1[KOG0106]
rs-Chlamydomonas reinhardtii@jgi_Chlre3_120019_RRM_1rs-Chlamydomonas reinhardtii@jgi_Chlre3_80366_RRM_1
rs-Physcomitrella patens@jgi_Phypa1_1_167387_RRM_1[KOG0106]rs-Selaginella moellendorfii@jgi_Selmo1_82477_e_gw1_5_1267_1_RRM_1[KOG0106]rs-Selaginella moellendorfii@jgi_Selmo1_124209_e_gw1_74_375_1_RRM_1[KOG0106]
rs-Arabidopsis thaliana@NP_567120_RRM_1[SR|RSp31][KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_552308_eugene3_00021623_RRM_1[KOG0106]rs-Populus trichocarpa@jgi_Poptr1_1_245070_gw1_XIV_1813_1_RRM_1[KOG0106]rs-Arabidopsis thaliana@NP_182184_RRM_1[SR|RSp31a][KOG0106]
rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5030607_Sb01g049590_RRM_1[KOG0106]rs-Oryza sativa_japonica_cultivar_group@NP_001052061_RRM_1[SR|RSp29][KOG0106]
rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5056945_Sb06g001100_RRM_1[SR|RSp29][KOG0106]2rs-Chlamydomonas reinhardtii@jgi_Chlre3_120019_RRM_2[KOG0106]
2rs-Chlamydomonas reinhardtii@jgi_Chlre3_80366_RRM_2[KOG0106]2rs-Volvox carteri@jgi_Volca1_80657_RRM_1
2rs-Chlorella sp._NC64A@jgi_ChlNC64A_1_25380_e_gw1_15_148_1_RRM_22rs-Cyanidioschyzon merolae@gnl_CMER_CMO009C_RRM_2
2rs-Selaginella moellendorfii@jgi_Selmo1_124209_e_gw1_74_375_1_RRM_22rs-Selaginella moellendorfii@jgi_Selmo1_82477_e_gw1_5_1267_1_RRM_2
2rs-Physcomitrella patens@jgi_Phypa1_1_167387_RRM_22rs-Oryza sativa_japonica_cultivar_group@NP_001052061_RRM_2
2rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5056945_Sb06g001100_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_552308_eugene3_00021623_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_245070_gw1_XIV_1813_1_RRM_22rs-Arabidopsis thaliana@NP_973702_RRM_12rs-Arabidopsis thaliana@NP_182184_RRM_22rs-Arabidopsis thaliana@NP_567120_RRM_2
2rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5030607_Sb01g049590_RRM_22rs-Oryza sativa_japonica_cultivar_group@NP_001045729_RRM_2
2rs-Sorghum bicolor_BTx623@jgi_Sorbi1_5054582_Sb04g001910_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_411608_gw1_II_2943_1_RRM_2
2rs-Populus trichocarpa@jgi_Poptr1_1_244286_gw1_XIV_1029_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_423171_gw1_XII_1631_1_RRM_22rs-Populus trichocarpa@jgi_Poptr1_1_253698_gw1_XV_3134_1_RRM_22rs-Arabidopsis thaliana@NP_200017_RRM_22rs-Arabidopsis thaliana@NP_851174_RRM_2
2rs-Arabidopsis thaliana@NP_974616_RRM_1[SR|RSp40/SRp35][KOG0106]2rs-Arabidopsis thaliana@NP_001078447_RRM_12rs-Arabidopsis thaliana@NP_194280_RRM_2
RRM2
RS "plant"
RRM1
RS "plant"
ASF-like
"plant"
Fig. S29
184
54 82
56
98
91 88
98
75 93
89
100
99 98
71
87
97 94
69
83
64
78
64
64
80
56
99
62
98 95
100
50 51
56
90
80
74 68
82
74
98
90
56
52 70
98
99
88
99
56
100
96
99 92
99
100
100 56
78
94
50
100
73 73
98
92
96 94
57
scl-Volvox carteri@jgi_Volca1_121229_RRM_1[KOG0415]scl-Arabidopsis thaliana@NP_567021_RRM_1[SR|SCL30][KOG0122]
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5056881_Sb05g027700_RRM_1scl-Oryza sativa_japonica_cultivar_group@NP_001068546_RRM_1[KOG0127]
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5047478_Sb0514s002010_RRM_1[KOG0110]scl-Oryza sativa_japonica_cultivar_group@NP_001046448_RRM_1[SR|SCL30a]scl-Oryza sativa_japonica_cultivar_group@NP_001067091_RRM_1[SR|SCL30b]
scl-Populus trichocarpa@jgi_Poptr1_1_656109_grail3_0049021701_RRM_1[KOG0122]scl-Populus trichocarpa@jgi_Poptr1_1_227475_gw1_X_2172_1_RRM_1[KOG0127]
scl-Selaginella moellendorfii@jgi_Selmo1_8401_gw1_62_42_1_RRM_1[KOG4207]scl-Physcomitrella patens@jgi_Phypa1_1_108464_RRM_1scl-Physcomitrella patens@jgi_Phypa1_1_141868_RRM_1scl-Selaginella moellendorfii@jgi_Selmo1_8339_gw1_49_32_1_RRM_1[KOG4207]
scl-Oryza sativa_japonica_cultivar_group@NP_001050168_RRM_1scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049384_Sb01g034590_RRM_1[KOG0127]scl-Populus trichocarpa@jgi_Poptr1_1_814124_estExt_fgenesh4_kg___RRM_1
scl-Arabidopsis thaliana@NP_197382_RRM_1[SR|SCL28][KOG0127]scl-Populus trichocarpa@jgi_Poptr1_1_420699_gw1_VIII_2127_1_RRM_1[SR|SCL28]
scl-Selaginella moellendorfii@jgi_Selmo1_79810_e_gw1_3_146_1_RRM_1[KOG4207]scl-Selaginella moellendorfii@jgi_Selmo1_102070_e_gw1_25_62_1_RRM_1[KOG0148]
scl-Populus trichocarpa@jgi_Poptr1_1_256035_gw1_XVI_1974_1_RRM_1[SR|SCL25][KOG0111]scl-Populus trichocarpa@jgi_Poptr1_1_547618_eugene3_00010059_RRM_1scl-Arabidopsis thaliana@NP_187966_RRM_1[SR|SCL30a]scl-Arabidopsis thaliana@NP_001031195_RRM_1[SR|SR33/SCL33][KOG0110]scl-Arabidopsis thaliana@NP_564685_RRM_1[SR|SR33/SCL33][KOG0110]scl-Oryza sativa_japonica_cultivar_group@NP_001060372_RRM_1[SR|SCL25]scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5052097_Sb02g040350_RRM_1[SR|SCL25]scl-Oryza sativa_japonica_cultivar_group@NP_001050213_RRM_1[KOG4207]
scl-Sorghum bicolor_BTx623@jgi_Sorbi1_5049360_Sb01g034200_RRM_1srrp-Homo sapiens@ENSP00000358479_RRM_1[SRrp|SRrp35]
srrp-Mus musculus@ENSMUSP00000103794_RRM_1[SRrp|SRrp35][KOG0111]srrp-Homo sapiens@ENSP00000345293_RRM_1[SRrp|SRp38]srrp-Mus musculus@ENSMUSP00000030437_RRM_1[SRrp|SRp38][KOG0415]srrp-Homo sapiens@ENSP00000363576_RRM_1[SRrp|SRp38][KOG0111]srrp-Mus musculus@ENSMUSP00000099603_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000363577_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000340764_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000342913_RRM_1[SRrp|SRp38][KOG0111]srrp-Homo sapiens@ENSP00000363573_RRM_1[SRrp|SRp38][KOG0415]srrp-Mus musculus@ENSMUSP00000095455_RRM_1[SRrp|SRp38]srrp-Mus musculus@ENSMUSP00000101479_RRM_1[SRrp|SRp38][KOG0415]srrp-Mus musculus@ENSMUSP00000030438_RRM_1[SRrp|SRp38][KOG0111]
sc35-Micromonas pusilla_RCC299@jgi_MicpuN3_91839_estExt_Genewise2____RRM_1sc35-Micromonas pusilla_CCMP1545@jgi_MicpuC2_9129_gw1_3_931_1_RRM_1[KOG4207]sc35-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16908_gw1_5_1114_1_RRM_1[KOG4207]
sc35-Ostreococcus lucimarinus@jgi_Ost9901_3_8174_RRM_1[KOG4207]sc35-Drosophila melanogaster@CG5442_PB_RRM_1[SR|SC35][KOG4207]
sc35-Caenorhabditis elegans@EEED8_7a_RRM_1[SR|CeSC35/rsp-4]sc35-Caenorhabditis elegans@EEED8_7b_RRM_1[SR|CeSC35/rsp-4][KOG4207]
sc35-Mus musculus@ENSMUSP00000078984_RRM_1[KOG4207]sc35-Homo sapiens@ENSP00000381889_RRM_1[KOG4207]
sc35-Homo sapiens@ENSP00000353089_RRM_1[SR|SC35][KOG4368]sc35-Mus musculus@ENSMUSP00000072182_RRM_1[SR|SC35][KOG4207]sc35-Homo sapiens@ENSP00000293233_RRM_1[SR|SC35][KOG4368]sc35-Mus musculus@ENSMUSP00000090059_RRM_1[SR|SC35][KOG4368]
sc35-Oryza sativa_japonica_cultivar_group@NP_001060322_RRM_1[SR|SC35b][KOG4207]sc35-Oryza sativa_japonica_cultivar_group@NP_001050263_RRM_1[SR|SC35c][KOG4207]
sc35-Sorghum bicolor_BTx623@jgi_Sorbi1_5029845_Sb01g033710_RRM_1[KOG4207]sc35-Arabidopsis thaliana@NP_851261_RRM_1[SR|SC35][KOG4207]
sc35-Populus trichocarpa@jgi_Poptr1_1_645719_grail3_0067008905_RRM_1[SR|SC35b][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_672394_grail3_1445000102_RRM_1[SR|SC35a][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_559112_eugene3_00050727_RRM_1[SR|SC35a][KOG4207]sc35-Populus trichocarpa@jgi_Poptr1_1_709848_estExt_Genewise1___RRM_1[KOG4207]
sc35-Oryza sativa_japonica_cultivar_group@NP_001062094_RRM_1[SR|SC35a][KOG0415]sc35-Selaginella moellendorfii@jgi_Selmo1_7952_gw1_7_122_1_RRM_1[SR|SC35a][KOG4207]sc35-Physcomitrella patens@jgi_Phypa1_1_172957_RRM_1[KOG0415]
sc35-Physcomitrella patens@jgi_Phypa1_1_122960_RRM_1[KOG4207]sc35-Selaginella moellendorfii@jgi_Selmo1_134332_e_gw1_124_43_1_RRM_1[SR|SC35a][KOG4207]
sc35-Cyanidioschyzon merolae@gnl_CMER_CML202C_RRM_1sc35-Sorghum bicolor_BTx623@jgi_Sorbi1_5059167_Sb07g029000_RRM_1[KOG0147]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045954_Sb09g004726_RRM_1[KOG0107]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045953_Sb09g004723_RRM_1[KOG0109]
rs2z-Oryza sativa_japonica_cultivar_group@NP_001054731_RRM_1[SR|RSZ39]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5045949_Sb09g004685_RRM_1[KOG0106]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5060000_Sb09g001920_RRM_1[SR|RSZ36][KOG0106]rs2z-Oryza sativa_japonica_cultivar_group@NP_001054489_RRM_1[SR|RSZ36][KOG0109]rs2z-Oryza sativa_japonica_cultivar_group@NP_001049771_RRM_1[SR|RSZ37b][KOG0109]
rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5059999_Sb09g001910_RRM_1[SR|RSZ36][KOG0109]rs2z-Oryza sativa_japonica_cultivar_group@NP_001042066_RRM_1[SR|RSZ37a][KOG0109]rs2z-Sorghum bicolor_BTx623@jgi_Sorbi1_5052652_Sb03g005500_RRM_1[KOG0109]
rs2z-Arabidopsis thaliana@NP_850280_RRM_1[SR|RSZ33][KOG0107]rs2z-Arabidopsis thaliana@NP_190918_RRM_1[SR|RSZ32][KOG0107]
rs2z-Populus trichocarpa@jgi_Poptr1_1_667717_grail3_0004036801_RRM_1[SR|RSZ37b][KOG0107]rs2z-Populus trichocarpa@jgi_Poptr1_1_653760_grail3_0013007302_RRM_1[SR|RSZ37b][KOG0107]
srp457-Homo sapiens@ENSP00000377892_RRM_1[SR|SRp40][KOG0105]srp457-Homo sapiens@ENSP00000342294_RRM_1[SR|SRp40][KOG0106]srp457-Mus musculus@ENSMUSP00000105985_RRM_1[SR|SRp40][KOG0106]srp457-Mus musculus@ENSMUSP00000105983_RRM_1[SR|SRp40][KOG0106]srp457-Mus musculus@ENSMUSP00000021562_RRM_1[SR|SRp40][KOG0106]srp457-Homo sapiens@ENSP00000362900_RRM_1[SR|SRp75][KOG0105]srp457-Mus musculus@ENSMUSP00000061474_RRM_1[SR|SRp75][KOG0105]
srp457-Mus musculus@ENSMUSP00000017065_RRM_1[SR|SRp55][KOG0105]srp457-Homo sapiens@ENSP00000362251_RRM_1[SR|SRp55][KOG0106]srp457-Homo sapiens@ENSP00000244020_RRM_1[SR|SRp55][KOG0105]srp457-Drosophila melanogaster@CG10851_PE_RRM_1[SR|SRp55][KOG0105]srp457-Drosophila melanogaster@CG10851_PD_RRM_1[SR|Hrp45][KOG0106]srp457-Drosophila melanogaster@CG10851_PC_RRM_1[SR|SRp55][KOG0105]srp457-Drosophila melanogaster@CG10851_PB_RRM_1[SR|SRp55][KOG0106]srp457-Drosophila melanogaster@CG10851_PF_RRM_1[SR|Hrp45][KOG0106]
srp457-Caenorhabditis elegans@T28D9_2a_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]srp457-Caenorhabditis elegans@T28D9_2b_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]srp457-Caenorhabditis elegans@T28D9_2d_RRM_1[SR|CeSC35-2/rsp-5][KOG0106]
srp457-Caenorhabditis elegans@W02B12_2_RRM_1[SR|CeSRp40/rsp-2][KOG0106]srp457-Caenorhabditis elegans@W02B12_3b_RRM_1[SR|CeSRp75/rsp-1][KOG0106]srp457-Caenorhabditis elegans@W02B12_3a_RRM_1[SR|CeSRp75/rsp-1][KOG0106]srp457-Caenorhabditis elegans@W02B12_3c_RRM_1[SR|CeSRp75/rsp-1][KOG0106]
asflkpl-Chlorella sp._NC64A@jgi_ChlNC64A_1_36976_estExt_Genewise1Plus____RRM_1asflkpl-Oryza sativa_japonica_cultivar_group@NP_001060608_RRM_1[SR|SRp33a][KOG0105]
asflkpl-Sorghum bicolor_BTx623@jgi_Sorbi1_5035702_Sb03g013010_RRM_1[SR|SR20][KOG0105]asflkan-Homo sapiens@ENSP00000229390_RRM_1[SR|SRp30c][KOG0105]asflkan-Mus musculus@ENSMUSP00000031513_RRM_1[SR|SRp30c][KOG0105]
asflkan-Drosophila melanogaster@CG6987_PA_RRM_1[KOG0105]asflkan-Mus musculus@ENSMUSP00000103553_RRM_1[SR|ASF/SF2][KOG0105]asflkan-Homo sapiens@ENSP00000258962_RRM_1[SR|ASF/SF2][KOG0105]asflkan-Mus musculus@ENSMUSP00000078792_RRM_1[SR|ASF/SF2][KOG0105]
asflkpl-Oryza sativa_japonica_cultivar_group@NP_001055323_RRM_1[SR|SRp33b][KOG0105]asflkpl-Arabidopsis thaliana@NP_172386_RRM_1[SR|SRp30][KOG0105]asflkpl-Arabidopsis thaliana@NP_683288_RRM_1[SR|SRp30][KOG0105]
asflkpl-Arabidopsis thaliana@NP_850933_RRM_1[SR|SR1/SRp34][KOG0105]p p p
ASF-like
"animal"
SRp40
SRp55
SRp75
RS2Z
"plant"
SC35
SRrp
SCL
N1
N5
N6
Fig. S29
185
0.36
100
98 92
92
80
77100
72
100 72
62
83
62 96
100
74
51
54 80
99
99
99
100
88 58
93100
51
77 86
85
55
78100
96
99
100
92
60
sr45-Chlorella sp._NC64A@jgi_ChlNC64A_1_138910_IGS_gm_22_00151_RRM_1sr45-Volvox carteri@jgi_Volca1_105177_RRM_1[KOG0462]
rnps1-Caenorhabditis elegans@K02F3_11_1_RRM_1[KOG4209]rnps1-Drosophila melanogaster@CG41105_PC_RRM_1
rnps1-Drosophila melanogaster@CG16788_PA_RRM_1rnps1-Homo sapiens@ENSP00000380275_RRM_1[RNPS1|RNPS1][KOG4209]rnps1-Mus musculus@ENSMUSP00000111028_RRM_1[RNPS1|RNPS1][KOG4209]
rnps1-Mus musculus@ENSMUSP00000057332_RRM_1[KOG4209]rnps1-Mus musculus@ENSMUSP00000111025_RRM_1[RNPS1|RNPS1][KOG4209]
sr45-Micromonas pusilla_RCC299@jgi_MicpuN3_63440_EuGene_1300010090_RRM_1sr45-Micromonas pusilla_CCMP1545@jgi_MicpuC2_9037_gw1_7_479_1_RRM_1
sr45-Physcomitrella patens@jgi_Phypa1_1_105411_RRM_1sr45-Physcomitrella patens@jgi_Phypa1_1_166555_RRM_1
sr45-Populus trichocarpa@jgi_Poptr1_1_823076_estExt_fgenesh4_pg___RRM_1sr45-Oryza sativa_japonica_cultivar_group@NP_001054414_RRM_1[KOG0117]
sr45-Oryza sativa_japonica_cultivar_group@NP_001045458_RRM_1sr45-Sorghum bicolor_BTx623@jgi_Sorbi1_5054420_Sb03g046480_RRM_1
sr45-Arabidopsis thaliana@NP_973844_RRM_1[SR|SR45]sr45-Arabidopsis thaliana@NP_173107_RRM_1[SR|SR45]
sr45-Selaginella moellendorfii@jgi_Selmo1_424875_fgenesh2_pg____RRM_1sr45-Selaginella moellendorfii@jgi_Selmo1_446044_estExt_fgenesh2_pg____RRM_1
9g8-Drosophila melanogaster@CG5655_PA_RRM_1[KOG0107]9g8-Homo sapiens@ENSP00000368134_RRM_1[SR|9G8][KOG0107]9g8-Homo sapiens@ENSP00000368146_RRM_1[SR|9G8][KOG0107]9g8-Homo sapiens@ENSP00000325905_RRM_1[SR|9G8]9g8-Mus musculus@ENSMUSP00000070983_RRM_1[SR|9G8][KOG0107]9g8-Mus musculus@ENSMUSP00000108040_RRM_1[SR|9G8][KOG0107]9g8-Mus musculus@ENSMUSP00000066393_RRM_1[SR|9G8][KOG0107]
srp20-Drosophila melanogaster@CG10203_PA_RRM_1[SR|9G8][KOG0107]srp20-Mus musculus@ENSMUSP00000110365_RRM_1[SR|SRp20][KOG0107]srp20-Homo sapiens@ENSP00000362820_RRM_1[SR|SRp20][KOG0107]srp20-Mus musculus@ENSMUSP00000100538_RRM_1[SR|SRp20][KOG0107]srp20-Homo sapiens@ENSP00000344762_RRM_1[SR|SRp20][KOG0107]srp20-Mus musculus@ENSMUSP00000049025_RRM_1[SR|SRp20][KOG0107]9g8-Drosophila melanogaster@CG1987_PA_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PB_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PD_RRM_1[KOG0107]9g8-Drosophila melanogaster@CG17136_PC_RRM_1[KOG0107]
9g8-Caenorhabditis elegans@C33H5_12c_RRM_1[SR|CeSRp20/rsp-6][KOG0107]9g8-Caenorhabditis elegans@C33H5_12b_1_RRM_1[SR|CeSRp20/rsp-6][KOG0107]9g8-Caenorhabditis elegans@C33H5_12a_2_RRM_1[SR|CeSRp20/rsp-6][KOG0116]
rsz-Chlamydomonas reinhardtii@jgi_Chlre3_132362_RRM_1[KOG0107]rsz-Chlorella sp._NC64A@jgi_ChlNC64A_1_139931_IGS_gm_27_00109_RRM_1[KOG0107]rsz-Chlamydomonas reinhardtii@jgi_Chlre3_192053_RRM_1[KOG0107]rsz-Volvox carteri@jgi_Volca1_121301_RRM_1[KOG0107]
rsz-Chlorella sp._NC64A@jgi_ChlNC64A_1_135849_IGS_gm_14_00382_RRM_1rsz-Populus trichocarpa@jgi_Poptr1_1_248500_gw1_XIX_900_1_RRM_1[SR|SRZ21/RSZ21][KOG0107]
rsz-Physcomitrella patens@jgi_Phypa1_1_143810_RRM_1[KOG0107]rsz-Physcomitrella patens@jgi_Phypa1_1_151194_RRM_1[KOG0107]rsz-Selaginella moellendorfii@jgi_Selmo1_172361_estExt_Genewise1Plus____RRM_1rsz-Selaginella moellendorfii@jgi_Selmo1_68846_gw1_3_1555_1_RRM_1[KOG0107]
rsz-Arabidopsis thaliana@NP_564208_RRM_1[SR|SRZ21/RSZ21]rsz-Arabidopsis thaliana@NP_194886_RRM_1[SR|SRZ22/RSZ22][KOG0107]
rsz-Arabidopsis thaliana@NP_180035_RRM_1[SR|RSZ22a]rsz-Populus trichocarpa@jgi_Poptr1_1_261622_gw1_XVIII_2163_1_RRM_1[KOG0116]rsz-Populus trichocarpa@jgi_Poptr1_1_583122_eugene3_01470007_RRM_1[SR|RSZp21a][KOG0107]rsz-Populus trichocarpa@jgi_Poptr1_1_583120_eugene3_01470005_RRM_1[SR|RSZ22a]
rsz-Oryza sativa_japonica_cultivar_group@NP_001057018_RRM_1[SR|RSZp21a]rsz-Oryza sativa_japonica_cultivar_group@NP_001047400_RRM_1[SR|RSZp23][KOG0107]rsz-Sorghum bicolor_BTx623@jgi_Sorbi1_5061430_Sb10g005960_RRM_1[SR|RSZp21a]
rsz-Oryza sativa_japonica_cultivar_group@NP_001048352_RRM_1[SR|RSZp21b]rsz-Sorghum bicolor_BTx623@jgi_Sorbi1_5056021_Sb04g035540_RRM_1[SR|RSZp21b]
scl-Micromonas pusilla_RCC299@jgi_MicpuN3_74643_gw2_11_587_1_RRM_1[KOG0107]scl-Micromonas pusilla_CCMP1545@jgi_MicpuC2_11901_gw1_8_619_1_RRM_1[KOG4207]
scl-Ostreococcus sp._RCC809@jgi_OstRCC809_1_16959_gw1_4_1177_1_RRM_1[KOG0108]scl-Ostreococcus tauri@jgi_Ostta4_7793_RRM_1[KOG0108]
scl-Ostreococcus lucimarinus@jgi_Ost9901_3_9858_RRM_1[KOG0108]scl-Chlorella sp._NC64A@jgi_ChlNC64A_1_135593_IGS_gm_14_00126_RRM_1[KOG4207]scl-Chlamydomonas reinhardtii@jgi_Chlre3_188086_RRM_1scl-Volvox carteri@jgi_Volca1_120666_RRM_1
scl-Chlamydomonas reinhardtii@jgi_Chlre3_113900_RRM_1[KOG4207]scl-Volvox carteri@jgi_Volca1_73973_RRM_1[KOG4207]scl-Chlorella sp._NC64A@jgi_ChlNC64A_1_17896_gw1_13_295_1_RRM_1
scl-Chlamydomonas reinhardtii@jgi_Chlre3_116256_RRM_1jg
SRp20 9G8
RSZ
"plant"
SR45
RNPS1
N1
Fig. S29
186