The Hyperglycemia and Adverse Pregnancy Outcome Study
Featured Article:
Patrick M. Catalano, M.D., H. David McIntyre, M.D., J. Kennedy Cruickshank, M.D., David R. McCance, M.D., Alan R. Dyer, Ph.D., Boyd E. Metzger, M.D., Lynn P. Lowe, Ph.D., Elisabeth R. Trimble, M.D., Donald R. Coustan, M.D.,
David R. Hadden, M.D., Bengt Persson, M.D. Ph.D., Moshe Hod, M.D., Jeremy J.N. Oats, M.D., For the Hapo Study Cooperative Research Group
Diabetes Care Volume 35: 780-786
April, 2012
Study Objective
• To determine associations of gestational diabetes mellitus (GDM) and obesity with adverse pregnancy outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study
Catalano P et al. Diabetes Care 2012;35:780-786
Study Design
• Participants underwent a 75-g OGTT between 24 and 32 weeks • GDM diagnosed post hoc using IADPSG criteria • Neonatal anthropometrics and cord serum C-peptide were
measured • Adverse pregnancy outcomes included birth weight, newborn
percent body fat, and cord C-peptide >90th percentiles, primary cesarean delivery, preeclampsia, and shoulder dystocia/birth injury
• Multiple logistic regression used to examine associations of
GDM and obesity with outcomes
Catalano P et al. Diabetes Care 2012;35:780-786
Catalano P et al. Diabetes Care 2012;35:780-786
Catalano P et al. Diabetes Care 2012;35:780-786
Catalano P et al. Diabetes Care 2012;35:780-786
Conclusions
•Both maternal GDM and obesity are independently associated with adverse pregnancy outcomes •Their combination has a greater impact than either one alone
Catalano P et al. Diabetes Care 2012;35:780-786