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Proceedings of the

National Academy ofs Sciences

of the United States of America

VOLUME 5 5 JANUARY-JUNE, 1966

S O F T

EDITORIAL BOARD OF THlE PROCEEDINGS

SAUNDERS MAC LANE, Chairman and Editor JOHN T. EDSALL, Vice Chairman and Associate Editor

MERLE A. TuvE, Home Secretary HARRISON S. BROWN, Foreign Secretary

MANSON BENEDICT CARL DJERASSI KATHERINE ESAU WTILLIAM A. FOWLER

L. V. BERKNER, Treasurer HERBERT FRIEDMAN R. W. GERARD ARTHUR KORNBERG S. E. LURIA

GORDON J. F. MACDONALD THEODORE T. PUCK H. L. SHAPIRO D. C. SPENCER

Editorial Associate: JOSEPHINE A. WILLIAMS

*

PUBLISHED MONTHLY BY THE NATIONAL ACADEMY OF SCIENCES



CONTENTS

NATIONAL ACADEMY OF SCIENCES

SYMPOSIUM ON MECHANISMS OF COLOR VISION .1311 INTRODUCTION .By C. H. Graham, Chairman 1311 FUNDAMENTAL STUDIES OF COLOR VISION FROM 1860 TO 1960 . By Deane B. Judd 1313 RETINAL PROCESSING OF VISUAL DATA .By Edward F. MacNichol, Jr. 1331 EFFECTS OF VARYING STIMULUS SIZE AND COLOR ON SINGLE LATERAL GENICULATE

CELLS IN RIHESUS MONKEYS . . . . By David H. Hubel and Torsten N. Wiesel 1345 DEFECTIVFE COLOR VISION AND ITS INHERITANCE .By George Wald 1347

PHYSICAL SCIENCES

MATHEMATICS

APPROXIMATION BY POLYNOMIALS: UNIFORM CONVERGENCE AS IMPLIED BY MEAN

CONVERGENCE .By J. L. Walsh 20 HEREDITARY RINGS .By Lance W. Small 25 ASYMPTOTIC DIOPHANTINE APPROXIMATIONS TO E .By William W. Adams 28 ASYMPTOTIC DIOPHANTINE APPROXIMATIONS .By Serge Lang 31 COMPLEX STRUCTURES ON S1 X S3 .By K. Kodaira 240 STRUCTURE THEORY FOR A CLASS OF JORDAN ALGEBRAS .By N. Jacobson 243 FUNDAMENTAL POLYHEDRONS AND LIMIT POINT SETS OF KLEINIAN GROUPS.

By Lars V. Ahlfors 251 INVESTIGATION ON GRoUPs OF EVEN ORDER, II. By Richard Brauer 254 SHRINKING A MANIFOLD IN A MANIFOLD . . By J. G. Hocking and Kyung Whan Kwun 259 ON THE CONTROLLABILITY OF A NONLINEAR SYSTEM . . . . By A. V. Balakrishnan 465 ON THE SYMMETRIES OF CERTAIN HYPERELASTIC SIMPLE LIQUID CRYSTALS

By C.-C. Wang 468 ON RIEMANNIAN MANIFOLDS WITH CONSTANT SCALAR CURVATURE ADMITTING A

CONFORMAL TRANSFORMATION GROUP .By Kentaro Yano 472 ON THE MATHEMATICAL MECHANISM OF PHASE TRANSITION

By Mark Kac and Colin J. Thompson 676 FURTHER REMARKS ON NONLINEAR P-COMPACT OPERATORS IN BANACH SPACE

.By W. V. Petryshyn 684 THE CLASSIFICATION OF THE COMPLEX PRIMITIVE INFINITE PSEUDOGROUPS

By V. Guillemin, D. Quillen, and S. Sternberg 687 ON THE CONSTRUCTION OF DIVISION RINGS BY THE DEFORMATION OF FIELDS

By Murray Gerstenhaber 690 ALGEBRAIC COMPLEXES APPLIED TO CHEMISTRY .By Peter H. Sellers 693 THE CATEGORY OF NOETHERIAN MODULES .By Tsit-Yuen Lam 1038 CONNECTIVITY OF PERIPHERALLY CONTINUOUS FUNCTIONS. . . By G. T. Whyburn 1040 HYPERFUNCTIONS AND LINEAR PARTIAL DIFFERENTIAL EQUATIONS . . By Reese Harvey 1042 THE PLEMELJ FORMULAS WITH UNRESTRICTED APPROACH, AND THE CONTINUITY OF

CAUCHY-TYPE INTEGRALS .By Frederick Bagemihl 1046 THE RESIDUE CALCULUS AND SOME TRANSCENDENTAL RESULTS IN ALGEBRAIC GEOMETRY, I

By Phillip A. Griffiths 1303 THE RESIDUE CALCULUS AND SOME TRANSCENDENTAL RESULTS IN ALGEBRAIC

GEOMETRY, II .By Phillip A. Griffiths 1392 EXAMPLES OF SINGULAR NORMAL COMPLEX SPACES WHICH ARE TOPOLOGICAL MANIFOLDS

.By Egbert V. Brieskorn 1395 UNIQUENESS THEOREMS FOR POLYHEDRA. By J. J. Stoker 1398



ii CONTENTS

APPROXIMATION BY POLYNOMIALS: UNIFORM CONVERGENCE AS IMPLIED BY MVIEAN

CONVERGENCE, II. By J. L. Walsh 1405 ON THE CHERN NUMBERS OF CERTAIN COMPLEX AND ALMOST COMPLEX MANIFOLDS .

By A. Van de Ven 1624

ASTRONOMY

DYNAMICS OF SPHERICAL GALAXIES, II .By Philip M. Campbell 1 ON THE SPIRAL STRUCTURE OF DISK GALAXIES, II. OUTLINE OF A THEORY oF DENSITY

WAVES .By C. C. Lin and Frank H. Shu 229 PHOTOELECTRIC SPECTROPHOTOMETRY OF n CARINAE. By L. H. Aller 671 APPARENT L-UNAR ACTIVITY: HISTORICAL REVIEW.

By Jaylee Burley and Barbara Ml. Middlehurst 1007

PHYSICS

ON THE STRtESS-STRAIN RELATIONS FOR CUBIC CRYSTALS . . By T. Y. T homas 235 ANALOGY BETWEEN BODY FORCE AND INELASTIC STRAIN GRADIENT IN CUBIC CRYSTALS

AND ISOTROPIC BODIES. By Y. H. Lin 477 A STUDY OF WATER IN BIOLOGICAL SYSTEMS BY 017 MAGNETIC RESONANCE SPECTROSCOPY,

I. PRELIMINARY STUDIES AND XENON HYDRATES . . By Jay A. Glasel 479 ESR STUDY OF -y-IRRADIATED POLYNUCLEOTIDES By Janko N. Herak and Walter Gordy 698 QUANTUM CORRECTIONS TO THE THIRD AND FO-URTH VIRIAL COEFFICIENTS USING THE 6:12

POTENTIAL. By Sungwoon Kim and Douglas Henderson 705 LONGITUDINAL WAVES IN CUBIC CRYSTALS. By '. Y. 1Thomas lOtl HYDROGEN ADDITION RADICALS ON RNA AND THE NUCLEIC-ACID BASES AT 77?K

.By J. N. Herak and W. Gordy 1373

ENGINEERING

OBSERVATIONS CONCERNING MVJAGNETOAEBODYNAMIC DRAG AND SHOCI STfANDOFF

DISTANCE. By Gerald R. Seemann and Ali Bulent Cambel 457

CHEMISTRY

A NITIROXIDE-MALEIMIDE SPIN LABEL . By 0. Hayes Griffith and Harden M. McConnell 8 A FREQUENCY-MODULATED ULTRASONIC INTERFEROMETER: ADIABATIC COMP1RESSIBILITY

OF AQUEOUS SOLUTIONS OF NACL AND KCL AT 25?C By Frank T. Gucker, Cedric L. Chernick, and Phanibusan Roy-Chowdhury 12

SYNTHESIS OF HIGHLY DEUTERATED AMINO ACIDS .By A. 7'. Blomquist, . R. J. Cedergren, Bruce F. Hiscock, Spencer L. 7'ripp, and David N. Harpp 453

A QUANTITATIVE ANALYSIS OF THE BINDING OF N-AcYL DERlVATIVES OF a-AMINO-

AMIDES BY a-CHYMOQTRYPSIN. . By Carole L. Hamilton, Carl Niemann, and George S. Hammond 664

A SPIN-LABELED SUBSTRATE FOR a-CHYMOTRYPSIN By Lawrence J. Berliner and Harden Al. McConnell 708

CONFORMATION AND REACTION SPECIFICITY IN PYRIDOXAL PHOSPHATE ENZYMES

By Harmon C. Dunathan 712 TWISTED CIRCULAR DNA: SEDIMENTATION COEFFICIENTS AND THE NUMBER OF TWISTS

By Victor A. Bloomfield 717 PURINE BINDING TO DIN-UCLEOTIDES: EVIDENCE FOR BASE STACKING AND INSERTION

By Sunney I. Chan, Benedict W. Bangerter, and Heinrich H. Peter 720 ExcIMER FLUORESCENCE OF DINUCLEOTIDES, POLYNUCLEOTIDES, AND DNA

By J. Eisinger, M. Gueron, R. G. Shulman, and T. Yamane 1015 HALIDE IONS AS CHEMICAL PROBES FOR NMR ST'UDIES OF PROTEINS

By Thomas R. Stengle and John D. Baldeschwieler 1020



CONTENTS iii

THERMODYNAMIC FACTORS IN THE SYNTHESIS OF TWO-STRANDED NUCLEIC ACIDS

By Leonard Peller 1025 SIGNIFICANT STRUCTURE THEORY OF MOLECULES HAVING HINDERED INTERMOLECULAR

ROTATION IN THE CONDENSED PHASES . By Don R. McLaughlin and Henry Eyring 1031 STUDIES IN IRREVERSIBLE THERMODYNAMICS, V. STATISTICAL THERMODYNAMICS OF A

SIMPLE STEADY-STATE MEMBRANE MODEL. By Terrell L. Hill 1379 8-AZACYL(2.2.2)AZINE. . By V. Boekelheide and N. A. Fedoruk 1385 TRIPLET EXCITONS IN POLYADENYLIC ACID . By J. Eisinger and R. G. Shulman 1387

GEOPHYSICS

CHEMICAL EVENTS ON THEE PRIMITIVE EARTH .By Philip H. Abelson 1365

BIOLOGICAL SCIENCES

BOTANY

THE INTERACTION BETWEEN AUXIN AND ETHYLENE AND ITS ROLE IN PLANT GROWTH

By Stanley P. Burg and Ellen A. Burg 262 ORGANIZATION OF BEET YELLOWS-VIRUS INCLUSIONS IN LEAF CELLS OF Beta

.By K. Esau, J. Cronshaw, and L. L. Hoefert 486 LUMINESCENCE OF CHLOROPHYLL IN SPINACH CHLOROPLASTS INDUCED BY ACID-BASE

TRANSITION .By Berger C. Mayne and Roderick K. Clayton 494 FRACTURE FACES OF FROZEN MEMBRANES. By Daniel Branton 1048 THE HILL REACTION OF CHLOROPLASTS ISOLATED FROM GLUTARALDEHYDE-FIXED SPINACH

LEAVES . . By Roderic B. Park, Jeffrey Kelly, Susan Drury, and Kenneth Sauer 1056 THE ROLE OF CAROTENOIDS IN THE PHOTOSYNTHESIS OF GREEN PLANTS

By H. Lundegardh 1062 Ti-m ROLE OF SOLVENT PRESSURE IN OSMOTIC SYSTEMS . . . By P. F. Scholander 1407

GENETICS

INTERACTION OF NONALLELIC GENES ON CELLULAR ANTIGENS IN SPECIES HYBRIDS OF

COLUMBIDAE, II. IDENTIFICATION OF INTERACTING GENES . . . By M. R. Irwin 34 SYNTHESIS OF COLLAGEN AND HYALURONIC ACID BY FIBROBLAST HYBRIDS.

. . By Howard Green, Boris Ephrussi, Michihiro Yoshida, and David Hamerman 41 DOUBLE-STRANDEDNESS OF MEIOTIC PROPHASE CHROMATIDS TO LIGHT MICROSCOPE

OPTICS AND ITS RELATIONSHIP TO GENETIC RECOMBINATION.

By Marjorie P. Maguire 44 STUDIES ON MECHANISMS FOR THE MAINTENANCE OF CONSTANT MIUTABILITY:

MUTABILITY AND THE RESISTANCE TO MUTAGENS. . By Stephen Zamenhof, Lilo H. Heldenmuth, and Patrice J. Zamenhof 50

MUTATION WITHOUT SEGREGATION IN BACTERIA WITH REDUCED DARK REPAIR ABILITY

By H. E. Kubitschek 269 THE UNUSUAL MUTAGENIC SPECIFICITY OF AN E. coli MUTATOR GENE

By Charles Yanofsky, Edward C. Cox, and Virginia Horn 274 A MODEL FOR MRNA TRANSCRIPTION SUGGESTED BY SOME CHARACTERISTICS OF 2-AMINO-

PURINE MUTAGENESIS IN Salmonella . . . By Paul Margolin and F. H. Mukai 282 MORPHOGENESIS OF BACTERIOPHAGE T4 IN EXTRACTS OF MUTANT-INFECTED CEILLS .

By R. S. Edgar and W. B. Wood 498 HETERODUPLEX HETEROZYGOTES IN BACTERIOPHAGE T4 INVOLVING MUTATIONS OF

VARIOUS D[MENSIONS .By John W. Drake 506 DNA REPLICAT[ON. By H. E. Kubitschek and T. R. Henderson 512



iv CONTENTS

SPONTANEOUS ORIGIN OF AN INCIPIENT SPECIES IN THE Drosophila paulistorum COMPLEX .By Theodosius Dobzhansky and Olga Pavlovsky 727

ON THE INFLUENCE OF NATURAL SELECTION ON POPULATION SIZE . By William Felle? 733 SPONTANEOUS MUTATIONS ACCUMULATING IN BACTERIOPHAGE T4 IN THE COMPLETE

ABSENCE OF DNA REPLICATION. By John W. Drake 738 THE MOLECULAR BASIS FOR THE GENETIC CODE

By C. R. Woese, D. H. Dugre, W. C. Saxinger, and S. A. Dugre 966 HYBRIDIZATION OF DWARF HAMSTER CELLS BY UV-INACTIVATED SENDAI VIRUS

.By George Yerganian and Marilyn B. Nell 1066 POLYALLELIC RANDOM DRIFT IN RELATION TO EVOLUTION. . . . By Sewall Wright 1074 GENE-SPECIFIC MRNA, II. REGULATION OF MRNA SYNTHESIS IN E. COI? AFTER

INFECTION WITH BACTERIOPHAGE T4 By E. K. F. Bautz, T. Kasai, E. Reilly, and F. A. Bautz 1081

FUNCTION OF THE N CISTRON OF BACTERIOPHAGE LAMBDA

By Jay J. Protass and David Korn 1089 LOCATION OF GENETIC LOCI OF SOLUBLE RNA ON Bacillus subtilis CHRtOMOSOME

By M. Oishi, A. Oishi, and N. Sueoka 1095 DNA-STRAND SCISSION AND LOSS OF VIABILITY AFTER X IRRADIATION OF NORMAL AND

SENSITIZED BACTERIAL CELLS. By Henry S. Kaplan 1442 THE EFFECT OF CHROMOSOMES 5B, 5D, and 5A ON CHROMOSOMAL PAIRING IN Triticum

aestivum .By Moshe Feldman 1447 THE ANTIMUTAGENIC ACTION OF POLYAMINES: SUPPRESSION OF THE MUTAGENIC ACTION

OF AN E. coli MUTATOR GENE AND OF 2-AMINOPURINE

.By Herbert G. Johnson and Michael K. Bach 1453 GENE AGGREGATION: EVIDENCE FOR A COMING TOGETHER OF FUNCTIONALLY RELATED,

NOT CLOSELY LINKED GENES. . . . . By Henry J. Vogel and Donald F. Bacon 1456 FUNCTIONAL UNITS OF PHAGE S13: IDENTIFICATION OF Two GENES THAT 1)ETERMINE

THE STRUCTURE OF THE PHAGE COAT . . By Irwin Tessman and Ethel S. Tessman 1459 ASSEMBLY OF PHAGE LAMBDA in vitro .By J. Weigle 1462

ZOOLOGY

HERITABILITY OF CELLULAR DIFFERENTIATION: CLONAL GROWTH AND EXPRESSION OF

DIFFERENTIATION IN RETINAL PIGMENT CELLS in vitro .By Robert D. Cahn and Martha B. Cahn 106

HYBRIDIZATION OF MITOCHONDRIAL RNA WITH MITOCHONDRIAL AND NUCLEAR DNA IN

AGAR. By Douglas G. Humm and Jane H. Humm 114 THE INFLUENCE OF COLLAGEN ON THE DEVELOPMENT OF MUSCLE CLONES.

By Stephen D. Hauschka and Irwin R. Konigsberg 119 A GLIAL PROTEIN SPECIFIC FOR THE NERVOUS SYSTEM. . By H. Hyden and B. McEwen 354 ACTIVATION OF RNA SYNTHESIS ASSOCIATED WITH GASTRULATION ..

. By R. Bachvarova, E. H. Davidson, V. G. Allfrey, and A. E. Mirsky 358 CHANGING POPULATIONS OF MESSENGER RNA DURING SEA URCHIN DEVELOPMENT

By A. H. Whiteley, B. J. McCarthy, and H. R. Whiteley 519 EFFECTS OF RNA ON THE DEVELOPMENTAL POTENTIALITY OF THE POSTERIOR PRIMITIVE

STREAK OF THE CHICK BLASTODERM. By Somes Sanyal and M. C. Niu 743 EVAPORATIVE COOLING AND RESPIRATORY ALKALOSIS IN THE PIGEON

By William A. Calder, Jr., and Knut Schmidt-Nielsen 750 ACCUMULATION IN THE O6CYTE NUCLEUS OF A GENE PRODUCT ESSENTIAL FOR EMBRYONIC

DEVELOPMENT BEYOND GASTRULATION . . . By Robert Briggs and Gloria Cassens 1103 SPECTRAL ANALYSIS OF THE BINDING OF ACRIDINE ORANGE TO POLYTENE CHROMOSOMES

.By James W. Maclnnes and Robert B. Uretz 1109 THE FOUNDER PRINCIPLE AND COMPETITIVE ABILITY OF Tribolium.

By Peter S. Dawson and I. Michael Lerner 1114 THE FINE STRUCTURE OF THE IHYPOPHARYNGEAL GLAND CELI, OF THE HONEY BEE DIJRING

DEVELOPMENT AND SECRETION . . By Theophilus S. Painter and John J. Beisele 1414



CONTENTS v

PHYSIOLOGY

TOWARD A QUANTITATIVE VIEW OF THE ENGRAM .By Arthur Cherkin 88 THEORY OF THE FLOW OF ACTION CURRENTS IN ISOLATED MYELINATED NERVE FIBERS, IX

.By R. Lorente de No and V. Honrubia 91 RADIOIMMUNOASSAYABLE GLUCAGON LEVELS IN MAN: EFFECTS OF STARVATION, Hypo-

GLYCEMIA, AND GLUCOSE ADMINISTRATION. By A. M. Lawrence 316 THEORY OF THE FLOW OF ACTION CURRENTS IN ISOLATED MYELINATED NERVE FIBERS, X

.By R. Lorente de No and V. Honrubia 321 CONNECTIONS BETWEEN CELLS OF THE DEVELOPING SQUID AS REVEALED BY ELECTRO-

PHYSIOLOGICAL METHODS . . . By D. D. Potter, E. J. Furshpan, and E. S. Lennox 328 LACTATE AND PYRUVATE CONCENTRATIONS IN EXERCISED ISCHEMIC CANINE MUSCLE:

RELATIONSHIP OF TISSUE SUBSTRATE LEVEL TO LACTATE DEHYDROGENASE ISOZYME

PATTERN. . . . . . . . . . . . By Elliot S. Vesell and Peter E. Pool 756 REVERSIBLE ALTERATION OF THE STRUCTURE OF GLOBULAR PROTEINS BY ANESTHETIC

AGENTS .By D. Balasubramanian and D. B. Wetlaufer 762 THEORY OF THE FLOW OF ACTION CURRENTS IN ISOLATED MYELINATED NERVE FIBERS, XI

. By R. Lorente de No and V. Honrubia 766 THEORY OF THE FLOW OF ACTION CURRENTS IN ISOLATED MYELINATED NERVE FIBERS, XII

.By R. Lorente de No and V. Honrubia 1118

PATHOLOGY

INDUCTION OF LEUKEMIA IN RAT BY PULSE DOSES OF 7,12-DIMETHYLBENZ(A)ANTHRACENE

. . . . . 6 . . . . . By Charles B. Huggins and Taketoshi Sugiyama 74 POTENTIATION OF ONCOGENICITY OF ADENOVIRUS TYPE 12 GROWN IN AFRICAN GREEN

MONKEY KIDNEY CELL CULTURES PREINFECTED WITH SV40 VIRUS: PERSISTENCE OF BOTH T ANTIGENS IN THE TUMORS AND EVIDENCE FOR POSSIBLE HYBRIDIZATION

By Klaus Schell, W. T. Lane, M. J. Casey, and R. J. Huebner 81 A FURTHER CORRELATION BETWEEN THE RESPONSE OF LYSOGENIC BACTERIA AND TUMOR

CELLS TO CHEMICAL AGENTS.

By Albert H. Gelderman, Thomas L. Lincoln, Dean B. Cowie, and Richard B. Roberts 289 FURTHER OBSERVATIONS OF THE LYMPHOMAS OF AFRICAN CHILDREN.

By Gilbert Dalldorf, Fernanda Bergamini, and Patricia Frost 297 CELL GROWTH AND THE INITIATION OF TRANSFORMATION BY SV40

By George J. Todaro and Howard Green 302 AMYLOID, III. A PROTEIN RELATED TO THE SUBUNIT STRUCTURE OF HUMAN AMYLOID

FIBRILS . . . . . . . . . . . . By Earl P. Benditt and Nils Eriksen 308 THE EFFECTS OF NONTUMOR VIRUSES ON VIRUS-INDUCED LEUKEMIA IN MICE:

RECIPROCAL INTERFERENCE BETWEEN SENDAI VIRUS AND FRIEND LEUKEMIA VIRUS IN DBA/2 MICE .By E. Frederick Wheelock 774

RADIOMIMETIC BEVERAGES, DRUGS, AND MUTAGENS . . By Karl Sax and Hally J. Sax 1431 EVIDENCE FOR THE in vitro TRANSFER OF DEFECTIVE ROUS SARCOMA VIRUS GENOME FROM

HAMSTER TUMOR CELLS TO CHICK CELLS . . . . . . . i By Padman S. Sarma, William Vass, and Robert J. Huebner 1435

SEARCH FOR TUMOR-SPECIFIC IMMUNE REACTIONS IN BURKITT LYMPHOMA PATIENTS BY

THE MEMBRANE IMMUNOFLUORESCENCE REACTION

By George Klein, Peter Clifford, Eva Klein, and Jan Stjernsward 1628

MICROBIOLOGY

ON THE NATURE OF THE PNEUMOCOCCAL ACTIVATOR SUBSTANCE.

By Alexander Tomasz and J. L. Mosser 58 CLONAL STABILITY AND PHENOTYPIC EXPRESSION OF CHICK CARTILAGE CELLS in vitro

.By Hayden G. Coon 66



vi CONTENTS

NUCLEIC ACID HOMOLOGY STUDIES OF ADENOVIRUS TYPE 7-SV40 INTERACTIONS

By Paul R. Reich, Stephen G. Baum, James A. Rose, Wallace P. Rowe, and Sherman M. Weissman 336

IMMUNOFLUORESCENT STUDIES OF GROUP-SPECIFIC ANTIGEN OF THE AVIA\N SARCOMA-

LEUKOSIS VIRUSES . . . . By F. E. Payne, J. J. Solomon, and H. G. Purchase 341 ON THE CULTURE OF A MICROORGANISM SIMILAR TO THE PRECAMBRIAN MICROFOSSIL

Kakabekia umbellata BARGHOORN IN NH3-RICH ATMOSPHERES . - . . . . By S. M. Siegel and Constance Giumarro 349

STUDIES OF ADENOVIRUS-SV40 HYBRID VIRUSES, IV. AN ADENOVIRUS TYPE 2 STRAIN

CARRYING THE INFECTIOUS -SV40 GENOME

By Andrew M. Lewis, Jr., Kirsten 0. Prigge, and Wallace P. Rowe 526 DETERMINING FACTOR IN THE CAPACITY OF ROUS SARCOMA VIRUS TO INDUCE TUMORS IN

MAMMALS. By Hidesaburo Hanafusa and Teruko Hanafusa 532 PRODUCTION OF ALTERED CELL FOCI IN TISSUE CULTURE BY DEFECTIVE MOLONEY

SARCOMA VIRUS PARTICLES . . . . By Janet W. Hartley and Wallace P. Rowe 780 HETEROGENEOUS RNA'S OCCURRING DURING THE REPLICATION OF WESTERN EQUINE

ENCEPHALOMYELITIS VIRUS .By T. Sreevalsan and R. Z. Lockart, Jr. 974 STUDIES OF ADENOVIRUS-SV40 HYBRID VIRUSES, V. EVIDENCE FOR LINKAGE BETWEEN

ADENOVIRUS AND SV40 GENETIC MATERIALS

.By Wallace P. Rowe and Wendell E. Pugh 1126 INHIBITION OF SV40 ANTIGEN FORMATION BY INTERFERON

By Michael N. Oxman and Paul H. Black 1133 DIFFERENT EFFECTS OF CHLORAMPHENICOL, DACTINOMYCIN, AND STREPTOVITACIN A ON

TUMOR AND VTIRION ANTIGENS IN SV40 VIRUS-INFECTED CELLS

By Albert B. Sabin 1141 STUDIES OF SMALL DNA VIRUSES FOUND IN VARIOUS ADENOVIRUS PREPARATIONS:

PHYSICAL, BIOLOGICAL, AND IMMUNOLOGICAL CHAIRACTERISTICS.

.By M. David Hoggan, Neil R. Blacklow, and W. P. Rowe 1467

NNTHROPOLOGY

RECENT ADVANCES IN THE PREHIS*rORIC ARCHAEOLOGY OF FORMOSA

.By Kwang-chih Chang and Minze Stuiver 539) LATE PLEISTOCENE VEGETATION AND CLIMATE IN TAIWAN (FORMOSA)

.By Matsuo Tsukada 543

PSYCHOLOGY

VOCALIZATION AND HEARING IN THE LEOPARD LIZARD.

By Ernest Glen Wever, Marie-Claude Hepp-Reymond, and Jack A. Vernon 98 THE TRANSFER OF LEARNED BEHAVIOR FROM TRAINED TO UNTRAINED RATS BY MEANS OF

BR-AIN EXTRACTS, I . . . By Frank Rosenblatt, John T. Farrow, and Sam Rhine 548 THE TRANSFER OF LEARNED BEHAVIOR FROM TRAINED TO UNTRAINED RATS BY MEANS OF

BRAIN EXTRACTS, II . . . By Frank Rosenblatt, John T. Farrow, and Sam Rhine 787 THE OLFACTORY SENSE AND INFRARED RADIATION IN THE LARGE AMERICAN COCKROACH

By Walter R. Miles 1420 BRAIN FUNCTION AND MACROMOLECULES, I. INCORPORATION OF URIDINE INTO RNA OF

MOIJSE BRAIN DURING SHORT-TERM TRAINING EXPERIENCE .By

John TV. Zemp, John Eric Wilson, K. Schlesinger, W. 0. Boggan, and Edward Glassman 1423

BIOCHEMISTRY

INDIVIDUALITY IN NUTRITION: EFFECTS OF VITAMIN A-DEFICIENT AND OTHER

DEFICIENT DIETS ON EXPERIMENTAL ANIMALS

.By Roger J. Williams and Richard B. Pelton 126 MEMBRANE PROPERTIES OF LIVING MAMMALIAN CELLS AS STUDIED BY ENZYMATIC

HYDROLYSIS OF FLUOROGENIC ESTERS . By Boris Rotman and Ben W. Papermaster 134



CONTENTS vii

DIRECTION OF READING OF THE GENETIC MESSAGE, II . . . By Marvtin A. Smith, Margarita Salas, Wendell M. Stanley, Jr., Albert J. Wahba, and Severo Ochoa 141

N-FORMYLMETHIONYL-SRNA AS THE INITIATOR OF PROTEIN SYNTHESIS.

.By Jerry M. Adams and Mario R. Capecchi 147 In vitro PROTEIN SYNTHESIS: CHAIN INITIATION

. By Robert E. Webster, Dean L. Engelhardt, and Norton D. Zinder 155 STUDIES ON THE MECHANISM OF POLYPEPTIDE CHAIN TERMINATION IN CELL-FREE

EXTRACTS OF E. coli. By M. Clelia Ganoza and Tokumasa Nakamoto 162 ATP FORMATION CAUSED BY ACID-BASE TRANSITION OF SPINACH CHLOROPLASTS

By Andre Tridon Jagendorf and Ernest Uribe 170 ON THE RELATIONSHIP BETWEEN VITAMIN D ACTION AND ACTINOMYCIN-SENSITIVE

PROCESSES . . . . By J. Elwood Zull, E. Czarnowska-Misztal, and H. F. DeLuca 177 FRACTIONATION AND SPECIFICITIES OF Two ASPARTYL-RIBONUCLEIC ACID AND Two

PHENYLALANYL-RIBONUCLEIC ACID SYNTHETASES.

.By W. Edgar Barnett and J. L. Epler 184 CELL-FREE ACTIVITY OF A SULFATE BINDING SITE INVOLVED IN ACTIVE TRANSPORtT

By Arthur B. Pardee and Louise S. Prestidge 189 HYDRODYNAMIC CHANGES ACCOMPANYING THE THERMAL DENATURATION OF TRANSFER

RIBONUCLEIC ACID . . By David D. Henley, Tomas Lindahl, and Jacques R. Fresco 191 RECONSTITUTION OF FUNCTIONALLY ACTIVE RIBOSOMES FROM INACTIVE SUBPARTICLES AND

PROTEINS . . . By Keiichi Hosokawa, Robert K. Fujimura, and Masayasu Nomura 198 SUBUNIT ASSOCIATION AND CATALYTIC ACTIVITY OF URIDINE DIPHOSPHATE GALACTOSE-4-

EPIMERASE FROM YEAST. By Robert A. Darrow and Robert Rodstrom 205 COMPARISON OF GUANOSINE TRIPHOSPHATE SPLIT AND POLYPEPTIDE SYNTHESIS WITH A

PURIFIED E. coli SYSTEM. BY Yasutomi Nishizuka and Fritz Lipmann 212 NUCLEIC ACID AND PROTEINS ISOLATED FROM THE RAUSCHER MOUSE LEUKEMIA VIRUS

(MLV) .By Peter H. Duesberg and William S. Robinson 219 THE METABOLISM OF SPHINGOMYELIN, II. EVIDE. NCE OF AN ENZYMATIC DEFICIENCY IN

NIEMANN-PICK DISEASE.

By Roscoe 0. Brady, Julian N. Kanfer, Michael B. Mock, and Donald S. Frederickson 366 EFFECT OF ACETOXYCYCLOHEXIMIDE AND OF AN ACETOXYCYCLOHEXIMIDE-PUROMYCIN

MIXTURE ON CEREBRAL PROTEIN SYNTHESIS AND MEMORY IN MICE

By Louis B. Flexner and Josefa B. Flexner 369 A SPECULATION RELATING THE GENETIC CODE AND THE EVOLUTIONARY PROCESS .

By Ben Bloom 375 ENERGY TRANSFER IN DINUCLEOTIDES . By C. HMlAne, P. Douzou, and A. M. Michelson 376 INTERACTION OF NUCLEIC ACIDS, III. CHEMICAL LINKAGE OF THE CARCINOGEN 3,4-

BENZPYRENE TO DNA INDUCED BY X-RAY IRRADIATION-.

By S. A. Rapaport and Paul 0. P. Ts'o 381 CELL DIVISION, SH, KETOALDEHYDES, AND CANCER By L. G. Egytud and A. Szent-Gy8rgyi 388 HYDROXYLYSINE FORMATION FROM LYSINE DURING COLLAGEN BIOSYNTHESIS

. By Edwin A. Popenoe, Robert B. Aronson, and Donald D. Van Slyke 393 ON THE LIGAND FIELD OF IRON IN FERREDOXIN FROM SPINACH CHLOROPLASTS AND

RELATED NONHEME IRON ENZYMES

By Hans Brintzinger, Graham Palmer, and Richard H. Sands 397 AMINO ACID PRODUCTION BY A MITOCHONDRIAL FRACTION OF Neurospora crassa .

By J. A. Kinsey and R. P. Wagner 404 TESTOSTERONE BIOSYNTHESIS BY RABBIT TESTIS SLICES: GLUCOSE-UILC14 AS A CARBON

SOURCE FOR TESTICULAR STEROIDS AND TESTICULAR PROTEINS.

By Gerald M. Connell and Kristen B. Eik-Nes 410 THE NATURE AND LOCATION OF INTRAMOLECULAR CROSS-LINKS IN COLLAGEN

By Paul Bornstein, Andrew H. Kang, and Karl A. Piez 417 ROLE OF THE GOLGI COMPLEX IN THE INTRACELLULAR TRANSPORT OF SECRETORY

PROTEINS .By James D. Jamieson and George E. Palade 424 LINCOMYCIN, AN INHIBITOR OF AMINOACYL sRNA BINDING TO RIBOSOMES

By F. N. Chang, C. J. Sih, and B. Weisblum 431



vimi CONTENTS

NUCLEIC ACID OF THE RAUSCHER MOUSE LEUKEMIA VIRUS

By Peter T. Mora, Vivian W. McFarland, and Samuel W. Luborsky 438 DEPENDENCE OF THE CHEMICAL NATURE OF ANTIBODIES ON THE NET ELECTRICAL CHARGE

OF ANTIGENS .By Michael Sela and Edna Mozes 445 STAGES OF MEMORY FORMATION IN GOLDFISH: EVIDENCE FOR AN ENVIRONMENTAL

TRIGGER .By Roger E. Davis and Bernard W. Agranoff 555 SALT ACCUMULATION AND ADENOSINE TRIPHOSPHATE IN CARROT XYLEM TISSUE .

By M. R. Atkinson, Gail Eckermann, Mary Grant, and R. N. Robertson 560 ALTERATION OF VALYL-SRNA DURING SPORULATION OF Bacillus subtilis.

By Ichiro Kaneko and Roy H. Doi 564 SUPPRESSION OF THE SHUNT PATHWAY IN PRIMARY GOUT BY AZATHIOPRINE .

By Leif B. Sorensen 571 SYNTHESIS OF A MATERIAL WITH HIGH JUVENILE HORMONE ACTIVITY

By John H. Law, Ching Yuan, and Carroll M. Williams 576 CONFORMATIONAL DIFFERENCES AMONG PURIFIED SAMPLES OF TRANSFER RNA FROM

YEAST . . By Prem S. Sarin, Paul C. Zamecnik, Peter L. Bergquist, and Jesse F. Scott 579 THE PRESENCE OF Two MAJOR HEMOGLOBIN COMPONENTS IN AN INBRED STRAIN OF MICE

By Daniel B. Rifkin, Mary R. Rifkin, and William Konigsberg 586 STUDIES OF THE FORMATION OF TOBACCO MOSAIC VIRUS RIBONUCLEIC ACID, VII. FATE

OF TOBACCO MOSAIC VIRUS AFTER ENTERING THE HOST CELL . . By K. K. Reddi 593 AUTORADIOGRAPHY OF CHROMOSOMAL DNA FIBERS FROM CHINESE HAMSTER CELLS

.By Joel A. Huberman and Arthur D. Riggs 599 A POSSIBLE MECHANISM FOR INITIATION OF PROTEIN SYNTHESIS.

.By Tokumasa Nakamoto and Daniel Kolakofsky 606 MUTANTS OF BACTERIOPHAGE T4 UNABLE TO CAUSE BREAKDOWN OF HOST DNA .

By John S. Wiber.q 614 ENDOGENOUS INDUCTION OF THE GALACTOSE OPERON IN Escherichia coli K12

By H. C. P. Wu and H. M. Kalckar 622 ALTERED REPRESSION OF SOME ENZYMES OF SULFUR UTILIZATION IN A TEMPERATURE-

CONDITIONAL LETHAL MUTANT OF Neurospora .By Robert L. Metzenberg and Judith W. Parson 629

PARTICIPATION OF A DNA-RNA HYBRID COMPLEX IN in vivo GENETIC TRANSCRIPTION

By Marie N. Hayashi and Masaki Hayashi 635 ISOLATION AND PARTIAL CHARACTERIZATION OF METAPHASE CHROMOSOMES OF A MOUSE

ASCITES TUMOR .By Kenneth P. Cantor and John E. Hearst 642 THE STIMULATION OF GLOBIN SYNTHESIS BY HEME

By Arthur I. Grayzel, Pieter Horchner, and Irving M. London 650 GLYCOPEPTIDE TRANSPEPTIDASE AND D-ALANINE CARBOXYPEPTIDASE: PENICILLIN-

SENSITIVE ENZYMATIC REACTIONS

By Kazuo Izaki, Michio Matsuhashi, and Jack L. Strominger 656 ISOLATION OF THE DNA OF THE E. coli CHROMOSOME IN ONE PIECE . . By C. I. Davern 792 ALKYLATION OF A BRAIN TRANSPORT ADENOSINETRIPHOSPHATASE AT THE CARDIOTONIC

STEROID SITE BY STROPHANTHIDIN-3-HALOACETATES

By Lowell E. Hokin, Michael Mokotoff, and S. Morris Kupchan 797 RNA SYNTHESIS AND HISTONE ACETYLATION DURING THE COURSE OF GENE ACTIVATION

IN LYMPHOCYTES .By B. G. T. Pogo, V. G. Allfrey, and A. E. Mirsky 805 PROTEIN SYNTHESIS AND THE TEMPORAL CONTROL OF GENETIC TRANSCRIPTION DURING

SILIME MOLD DEVELOPMENT .By M. Sussman 813 ISOLATION OF HIGH-MOLECULAR-WEIGHT, P32-LABELED INFLUENZA VIRUS RIBONUCLEIC

ACID. By Hari 0. Agrawal and George Bruening 818 ON THE MECHANISM OF ANTIBODY SYNTHESIS: A SPECIES COMPARISON OF L-CHAINS

By Leroy E. Hood, William R. Gray, and William J. Dreyer 826 INHIBITION OF LYSOZYME SYNTHESIS BY ACTINOMYCIN D IN BACTERIOPHAGE T4-INFECTED

CELLS OF Escherichia coli .By Jay J. Protass and David Korn 832 SIMILARITY OF EFFECTS OF OXYGEN, SULFUR, AND SELENIUM ISOLOGS ON THE ACETYL-

CHOLINE RECEPTOR IN EXCITABLE MEMBRANES OF JUNCTIONS AND AXONS

By Philip Rosenberg, Henry G. Mautner, and David Nachmansohn 835



CONTENTS ix

INTRACELLULAR CONDITION OF Escherichia coli TRANSFER RNA. By C. D. Yegian, G. S. Stent, and E. M. Martin 839

THE y-AMINOBUTYRIC ACID SYSTEM IN RABBIT CEREBELLUM.

By Kinya Kuriyama, Bernard Haber, Betty Sisken, and Eugene Roberts 846 SERUM-INDUCED FORMATION OF LYsOSOMES IN HELA CELLS: A PROCESS SENSITIVE TO

ACTINOMYCIN D. . By Michael J. Ahearn, Terrell H. Hamilton, and John J. Biesele 852 AN RNA-IiSTONE COMPLEX IN MAMMALIAN CELLS: THE ISOLATION AND CHARACTERIZA-

TION OF A NEW RNA SPECIES

By William Benjamin, Orville A. Levander, Alfred Gellhorn, and Robert H. DeBellis 858 DEFICIENCIES OF CYSTATHIONASE AND HOMOSERINE DEHYDRATASE ACTIVITIES IN CYSTA-

THIONINURIA

By James D. Finkelstein, S. Harvey Mudd, Filadelfo Irreverre, and Leonard Laster 865 ALTERATIONS OF A MATERNALLY INHERITED MITOCHONDRIAL STRUCTURAL PROTEIN IN

RESPIRATORY-DEFICIENT STRAINS OF Neurospora. . i . . . . . . . . . . . By D. 0. Woodward and K. D. Munkres 872

STIMULATION OF FATTY ACID BIOSYNTHESIS BY PHOSPHORYLATED SUGARS

By S. J. Wakil, J. K. Goldman, 1. P. Williamson, and R. E. Toomey 880 SUSTAINED SINUSOIDAL OSCILLATIONS OF REDUCED PYRIDINE NUCLEOTIDE IN A CELL-

FREE EXTRACT OF Saccharomyces carlsbergensis .By Kendall Pye and Britton Chance 888

OPTICAL ROTATORY DISPERSION OF HEME PEPTIDE FROM CYTOCHROME C

.By David D. Ulmer 894 ACUTE DECREASE IN RNA POLYMERASE ACTIVITY OF RAT THYMUS IN RESPONSE TO

CORTISOL INJECTION .By Sachiko Nakagawa and Abraham White 900 VAN DER WAALS-LONDON INTERACTIONS AND THE CONFIGURATION OF HYDROGEN-BONDED

PURINE AND PYRIMIDINE PAIRS

By Bernard Pullman, Pierre Claverie, and Jacqueline Caillet 904 RNA CODONS AND PROTEIN SYNTHESIS, IX. SYNONYM CODON RECOGNITION BY MUL-

TIPLE SPECIES OF VALINE-, ALANINE-, AND METHIONINE-SRNA.

By D. A. Kellogg, B. P. Doctor, J. E. Loebel, and M. W. Nirenberg 912 PROLINE UPTAKCE BY AN ISOLATED CYTOPLASMIC MEMBRANE PREPARATION OF Escherichia

coli .By H. R. Kaback and E. R. Stadtman 920 A NEW FERREDOXIN-DEPENDENT CARBON REDUCTION CYCLE IN A PHOTOSYNTHETIC

BACTERIUM . . . . By M. C. W. Evans, Bob B. Buchanan, and Daniel I. Arnon 928 THE PARTICIPATION OF SRNA IN THE ENZYMATIC SYNTHESIS OF O-L-LYSYL PHOSPHATIDYL-

GLYCEROL IN Staphylococcus aureus By W. J. Lennarz, J. A. Nesbitt, III, and J. Reiss 934

RENATURATION OF TRANSFER RIBONUCLEIC ACIDS THROUGH SITE BINDING OF MAGNESIUM

By Tomas Lindahl, Alice Adams, and Jacques R. Fresco 941 Two INTERCONVERTIBLE FORMS Or TRYPTOPHANYL SRNA IN E. coli.

. . . . . . . . . . . 4 . By William J. Gartland and Noboru Sueoka 948 INDUCTION OF CELLULAR DNA SYNTHESIS BY POLYOMA VIRUS, III. INDUCTION IN PRO-

DUCTIVELY INFECTED CELLS . By Marguerite Vogt, Renato Dulbecco, and Basil Smith 956 TEMPLATE ACTIVITY OF URIDYLIC ACID-DIHYDROURIDYLIC ACID COPOLYMERS

By Fritz Rottman and Peter Cerutti 960 THE OPTICAL ROTATORY PROPERTIES OF THE 13-CONFIGURATION IN POLYPEPTIDES AND

PROTEINS .By P. K. Sarkar and Paul Doty 981 THE EFFECT OF HORMONES ON DNA. . By Melvin L. Goldberg and William A. Atchley 989 EVIDENCE FOR SEMICONSERVATIVE REPLICATION OF CIRCULAR POLYOMA DNA

... . . . . . . . . . . . . . . . . . By Bernhard Hirt 997 THE BALANCE OF PYRIDINE NUCLEOTIDES AND ATP IN ADIPOSE TISSUE

By Robert Rognstad and Joseph Katz 1148 CHEMICAL MODIFICATION OF THE ALLOSTERIC AND CATALYTIC SITES OF FRUCTOSE 1,6-

DIPHOSPHATASE. By Ora M. Rosen and Samuel M. Rosen 1156 DNA THIOLASE: THE ENZYMATIC TRANSFER OF SULFUR FROM CYSTEINE TO sRNA IN

Escherichia coli EXTRACTS . . . . By Richard S. Hayward and Samuel B. Weiss 1161 ENZYMATIC THIOLATION OF E. coli SRNA . .BBy Marie N. Lipsett and Alan Peterkofsky 1169



x (ONATENTS

OPTICAL ROTATORY IDISPERSION AND CIRCULAR DICHROISM OF THE ,-FORM OF SILK

FIBROIN IN SOLIJTION. By Eisaku lizuka and Jen 7Tsi Yang 1175 PHOSPHOPROTEIN METABOLISM IN ISOLATED LYMPHOCYTE NUCLEI

By Lewis J. Kleinsmith, Vincent G. Allfrey, and Alfred E. Mirsky 1182 REGIONAL AND TEMPORIAL CONTrROL OF GENETIC TRANSCRIPTION IN PHA.GE LAMBDA .

By A. Skalka 1190 THE AMINO-TERMINAL AMINO ACID SEQUENCES OF RABBIT IMMUNOGLOBULIN LIGHT

CHAINS. By Russell F. Doolittle 1195 A MOLECULAR MODEL FOR GENE REPRESSION

.By Jeffrey H. Miller and Henry M. Sobell 1201 PROPERTIES OF ANTIBODIES SYNTHESIZED BY CELLS in vitro IN THE PRESENCE AND AB-

SENCE OF STREPTOMYCIN. By Robert G. Krueger 1206 ELECTROKINETIC MECHANISM OF MINIATURE POSTSYNAPTIC POTENTIALS.

By L. Bass and W. J. Moore 1214 ON THE GENETICS OF ENZYME LO-CATIONAL SPECIFICITY

.By K. D. Munkres and D. 0. Woodward 1217 THE INHIBITION BY CHLORAMPHENICOL OF NASCENT PROTEIN FORMATION IN E. coli

By Michael J. Weber and J. A. DeMoss 1224 RE-EXAMINATION OF THE EFFECT OF DFP ON ELECTRICAL AND CHOLINESTERASE ACTIVITY

OF SQUID GIANT AXON . . By F. C. G. Hoskin, Philip Rosenberg, and M. Brzin 1231 THE SIZE OF THE POLYPEPTIDE PRECURSOR OF COLLAGEN HYDROXYPROLINE

By Lewis N. Lukens 1235 INTRAMITOCHONDRIAL PH CHANGES IN CATION ACCUMULATION

By Britton Chance and Leena Mela 1243 MODIFICATION OF TADPOLE LIVER CHROMATIN BY THYROXINE TREATMENT

By Ki-Han Kim and Philip P. Cohen 1251 A SEARCH FOR AN INTERMEDIATE INVOLVING A COMPLEMENT DURING SYNCHRONOUS

SYNTHESIS BY A PIURIFIED RNA REPLICASE . . By I. Haruna and S. Spiegelman 1256 REPLICATION OF VIRAL RNA, XI. SYNTHESIS OF VIRAL "MINUS" STRANDS in vitro

By Charles Weissmann and G(nter Feix 1264 THE RIBOSOME-BINDING SITES IN TURNIP YELLOW MOSAIC VIRUS RNA

.By James E. Dahlberg and Robert Haselkorn 1269 LOCATION OF A LOCAL LESION GENE IN TOBACCO MOSAIC VIRUS RNA.

By C. I. Kado and C. A. Knight 1276 RELATION OF RIBONUCLEASE AND RIBONUCLEASE INHIBITOR TO THE ISOLATION OF POLY-

SOMES FROM RAT LIVER. By Gunter Blobel and Van R. Potter 1283 Two CLASSES OF SPLEEN RIBOSOMES WITH DIFFERENT SENSITIVITIES TO CHLORAMPHENICOL

By Norman Talal and E. Dubois Exum 1288 MEMBRANES AS EXPRESSIONS OF REPEATING UNITS

.By David E. Green and James F. Perdue 1295 THE INFLUENCE OF POLYCYCLIC AROMATIC HYDROCARBONS ON BACTERIOPHAGE DEVELOP-

MENT, II By Wen-Tah Hsu, John W. Moohr, Albert Y. M. Tsai, and Samuel B. Weiss 1475

BINDING OF SPECIFIC sRNA TO 30S RIBOSOMAI SUBUNITS: EFFECT OF 50S RIBOSOMAL

SUBUNITS .By Iwao Suzuka, Hideko Kaji, and Akira Kaji 1483 ISOLATION OF THE NUCLEIC ACID OF MOUSE MAMMARY TUMOR VIRUS (MTV)

By Peter H. Duesberg and Phyllis B. Blair 1490 THE STRUCTURAL GENE FOR YEAST CYTOCHROME C .By Fred Sherman,

John W. Stewart, Emanuel Margoliash, John Parker, and Wayne Campbell 1498 PURIFICATION AND PROPERTIES OF THE REPLICATIVE INTERMEDIATE OF THE RNA

BACTERIOPHAGE R17 .By Richard M. Franklin 1504 REACTIONS OF QUININE, CHLOROQUINE, AND QUINACRINE WITH DNA AND THEIR

EFFECITS ON THE DNA AND RNA POLYMERASE REACTIONS

By Richard L. O'Brien, John G. Olenick, and Fred E. Hahn 1511 INITIATION OF E. coli PROTEINS. By Mario R. Capecchi 1517 A SOLUBLE DEOXYRIBONUCLEIC ACID IN THE MOSQUITO Aedes aegypti

By Calvin A. Lang and Frederick Meins, Jr. 1525



CONTENT'S xi

THE AMINO ACID SEQUENCE OF Clostridium butyricum FERREDOXIN.

By Ann Marie Benson, Howard F. Mower, and Kerry T. Yasunobu 1532 3-FORMING PROTEIN CHAIN IN A GLOBULAR ENZYME, DEOXYRIBONUCLEASE I .

By Ping-Yao Cheng 1535 A RATIONALE FOR AN ANALYSIS OF RNA REPLICATION

By S. Spiegelman and I. Haruna 1539 INSULIN SYNTHESIS BY RECOMBINATION OF A AND B CHAINS: A HIGHLY EFFICIENT

METHOD .By Panayotis G. Katsoyannis and Andrew Tometsko 1554 SEPARATION OF THREE MICRIOBIAL AMINO ACID POLYMERIZATION FACTORS.

By Jean Lucas-Lenard and Fritz Lipmann 1562 THE MECHANISM OF VIRAL CARCINOGENESIS BY DNA MAMMALIAN VIRUSES: VIRAL-

SPECIFIC RNA IN POLYRIBOSOMES OF ADENOVIRUS TUMOR AND TRANSFORMER) CELLS

By Kei Fujinaga and Maurice Green 1567 A RECEPTOR MOLECULE FOR ESTROGENS: ISOLATION FROM THE RAT UTERUS AND

PRELIMINARY CHARACTERIZATION .By David Toft and Jack Gorski 1574 REGULATION OF VIRUS-INDUCED DEOXYRIBONUCLEASES

By B. R. McAuslan and J. R. Kates 1581 POLYAMINES AND RNA SYNTHESIS IN A POLYAUXOTROPHIC STRAIN OF E. coli

By A. Raina and Seymour S. Cohen 1587 DIFFERENTIAL SYNTHESIS OF RIBONUCLEIC ACID IN PROSTATIC NUCLEI: EVIDENCE FOR

SELECTIVE GENE TRANSCRIPTION INDUCED BY ANDROGENS

.By Shutsung Liao, R. W. Barton, and Alice H. Lin 1593 REPLICATION AND INHERITANCE OF MITOCHONDRIAL DNA

By Edward Reich and David J. L. Luck 1600 THE SYNTHESIS OF INFECTIOUS RNA WITH A REPLICASE PURIFIED ACCORDING TO ITS

SIZE AND DENSITY .By N. R. Pace and S. Spiegeiman 1608 SOME PHYSICAL PROPERTIES OF RNA POLYMERASE . By John P. Richardson 1616

ERRATA

THE STRUCTURAL GENE FOR DEOXYRIBONUCLEIC ACID POLYMERASE IN BACTERIOPHAGES

T4 AND T5 .By A. de Waard, A. V, Paul, and I. R. Lehman 227 MOLECULAR COMPLEXES OF FLAVINS AND PHENOLS, III. FACTORS INFLUENCING SPECTRA

AND STABILITY .By Darrell E. Fleischman and Gordon Tollin 670 FACILITATION OF IMMUNE HEMOLYSIS BY AN INTERACTION BETWEEN RED CELL-SENSITIZING

ANTIBODY AND y-GLOBULIN ALLOTYPE ANTIBODY

By Eberhardt Weiler, Elsa W. Melletz, and Evelyn Breuninger-Peck 1005 A STUDY OF WATER IN BIOLOGICAL SYSTEMS BY 017 MAGNETIC RESONANCE SPECTROSCOPY,

I. PRELIMINARY STUDIES AND XENON HYDRATES . . . By Jay A. Glasel 1636

