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National Cheng Kung University

Department of Chemical Engineering

Research Summary

1

Introduction History The Department traced its root back to 1931 The original

institution Department of Applied Chemistry of Tainan

Technical College was founded by the Japanese authority

After the Restoration of Taiwan it was reorganized and

officially renamed as Department of Chemical Engineering in

1947 The Department has offered the Bachelor of Science

degree since its establishment Graduate studies including

Master of Science (MS) and Doctor of Philosophy (PhD)

degrees were initiated in 1964 and 1970 respectively

Faculty

There are currently 37 faculty members in our department

including 27 professors 4 associate professors 5 assistant

professors and 1 lecturer

RESEARCH Our faculty members are active in various research areas The vigorous research program is reflected by its outstanding outcomes Each year the faculty members publish more than one hundred and seventy research papers in renowned journals They also obtain many patents and offer technology transfer to local industries The major research topics in the department can be roughly categorized into four fields 1 Biotechnology and biochemical engineering 2 Optoelectronic materials and nanotechnology 3 Polymer materials and engineering 4 Energy technology and process systems

engineering

Student Each year we enroll around 145 freshmen 106 master students and 32 PhD students Undergraduate Program For undergraduate students the minimum credits for graduation is 144 including general courses required by the University and the Department (109~111 credits) and elective courses (no less than 34~36 credits) Graduate Program Minimum credits required for MS degree is 24 plus 6 credits of MS thesis Minimum credits required for PhD degree is 18 plus 12 credits of PhD thesis Students in PhD program are required to pass a qualifying examination before the end of the third year in the program The PhD candidate shall complete and defend hisher thesis as well as present the thesis work in public

2

Table of Contents

吳 文 騰 Wen-Teng Wu 3

陳 志 勇 Chuh-Yuan Chen 5

楊 毓 民 Yu-Min Yang 7

劉 瑞 祥 Jui-Hsiang Liu 9

鍾 賢 龍 Shyan-Lung Chung 11

溫 添 進 Ten-Chin Wen 13

陳 雲 Yun Chen 15

郭 炳 林 Ping-Lin Kuo 17

吳 逸 謨 Eamor M Woo 19

陳 進 成 Chin-Cheng Chen 21

張 玨 庭 Chuei-Tin Chang 23

黃 世 宏 Shyh-Hong Hwang 25

洪 昭 南 Frankin Chau-Nan Hong 27

許 梅 娟 Mei-Jywan Syu 29

鄧 熙 聖 Hsisheng Teng 31

張 鑑 祥 Chien-Hsiang Chang 33

王 紀 Chai Wang 35

張 嘉 修 Jo-Shu Chang 37

林 睿 哲 Jui-Che Lin 39

陳 東 煌 Dong-Hwang Chen 41

陳 慧 英 Huey-Ing Chen 43

李 玉 郎 Yuh-Lang Lee 45

楊 明 長 Ming-Chang Yang 47

吳 季 珍 Jjih-Jen Wu 49

陳 炳 宏 Bing-Hung Chen 51

黃 耀 輝 Yao-Hui Huang 53

吳 煒 Wei Wu 55

鄭 智 元 Chu-Yuan Cheng 57

魏 憲 鴻 Wei-Hsien Hung 59

侯 聖 澍 Sheng-Shu Hou 61

莊 怡 哲 Yi-Je Juang 63

羅 介 聰 Chieh-Tsung Lo 65

詹 正 雄 Jeng-Shiung Jan 67

王 翔 郁 Hsiang-Yu Angie Wang 69

陳 美 瑾 Mei-Chin Chen 71

吳 文 中 Wen-Chung Wu 73

林 建 功 Chien-Kung Lin 75

3

Studies on lipid production from microalgae

Nannochloropsis oculata The proposed photo-bioreactor

Batch culture at different urea concentrations Semi-continuous cultivatoin

Immobilization of cellulase for hydrolysis the cell wall of microalgae

Wen-Teng Wu (吳文騰教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1968

MS Chemical Engineering National Cheng

Kung University Taiwan

1970

PhD Chemical Engineering National Cheng

Kung University Taiwan

1975

Email wtwumailnckuedutw

Tel 06-2757575-62001

Office Room 93915 Chemical Engineering Building

4

Electrospinning Reactor

Immobilization time (min)

20 40 60 80 100 120 140

Prot

ein

load

ing

(mg

prot

ein

g m

ater

ial)

0

20

40

60

80

100

120

140

Rel

ativ

e sp

ecif

ic a

ctiv

ity

()

0

20

40

60

80

100

120

Time (hr)

0 20 40 60 80 100

Con

cent

rati

on o

f re

duci

ng s

ugar

(g

L)

10

15

20

25

30

35

Effect of enzyme concentration Time course of cellulase to

on protein loading and relative specific hydrolysis the cell wall of microalgae activity

Immobilization of Lipase on Chitosan PVA Electrospinning membrane for Biodiesel Production

SEM photograph of the electrospun chitosan fibers

3wt chitosan PVA PVA

5wt chitosan PVA 5wt chitosan PVA with

1MNaOH treatment

5

Chuh-Yung Chen (陳志勇)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1981

MS Chemical Engineering National

Cheng Kung University Taiwan

1977

PhD Chemical Engineering National

Cheng Kung University Taiwan

1975

Email ccy7ccmailnckuedutw

Tel (06)-2757575 - 62643

Office Room 93B15 Chemical Engineering Building

6

Materials for Green Energy Technology Functional Polymers

CNT Nanocomposite Living Polymerization

Electrospinning

7

Nano-Colloidal Domain - where physics chemistry biology and technology meet

Recent developments in many modern nano-technologies involve new materials or

processes in which interfaces (or surfaces) and colloids play a crucial role They reveal the

interaction of a spectrum of disciplines in which physics chemistry biology and technology

intersect Understanding and utilizing the special properties of molecules at interfaces constitutes

goal of our research These include some of the themes in nano-colloid science self-assembly

construction of supramolecular architecture nanoconfinement and compartmentalization

superhydrophobic superhydrophilic surface patterning and adsorption at nanocystalline surface

A few of our current research topics which exemplify the breadth of our interests follows

Preparation of catanionic vesicles and its applications in drug and gene delivery

Novel liposome-like vesicular systems as carriers

for drug and gene delivery

Time (hr)

01 1 10 100 1000

Rel

ease

(

)

0

20

40

60

80

100

5 EtOH10 EtOH20 EtOH30 EtOH

10mM DeTMA-TS + 10mM CHOL

Surface Science and Engineering Nano-Colloid Lab Research Group

Yu-Min Yang (楊毓民教授)

Professor BS Chemical Engineering Tatung

Institute of Technology Taiwan

1977

MS Chemical Engineering National

Cheng Kung University Taiwan

1979

PhD Chemical Engineering National

Cheng Kung University Taiwan

1983

8

Creation of multifunctional surfaces by using layer-by-layer assembly strategy

By means of Langmuir-Blodgett deposition electrostatic assembly and self assembly nanoparticulate thin films with high transmittance superhydrophobicity superhydropholicity and photocatalysis characteristics can be fabricated for potential applications in self-cleaning microfluidics and biomedical materials

Mixed and sequential adsorption of dye sensitizers on nanocrystalline photoelectrodes of dye sensitized solar cells (DSSCs)

Molecular co-sensitizaton of organic dyes for DSSCs by dye cocktails and bandgap cascade approaches

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

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(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

1

Introduction History The Department traced its root back to 1931 The original

institution Department of Applied Chemistry of Tainan

Technical College was founded by the Japanese authority

After the Restoration of Taiwan it was reorganized and

officially renamed as Department of Chemical Engineering in

1947 The Department has offered the Bachelor of Science

degree since its establishment Graduate studies including

Master of Science (MS) and Doctor of Philosophy (PhD)

degrees were initiated in 1964 and 1970 respectively

Faculty

There are currently 37 faculty members in our department

including 27 professors 4 associate professors 5 assistant

professors and 1 lecturer

RESEARCH Our faculty members are active in various research areas The vigorous research program is reflected by its outstanding outcomes Each year the faculty members publish more than one hundred and seventy research papers in renowned journals They also obtain many patents and offer technology transfer to local industries The major research topics in the department can be roughly categorized into four fields 1 Biotechnology and biochemical engineering 2 Optoelectronic materials and nanotechnology 3 Polymer materials and engineering 4 Energy technology and process systems

engineering

Student Each year we enroll around 145 freshmen 106 master students and 32 PhD students Undergraduate Program For undergraduate students the minimum credits for graduation is 144 including general courses required by the University and the Department (109~111 credits) and elective courses (no less than 34~36 credits) Graduate Program Minimum credits required for MS degree is 24 plus 6 credits of MS thesis Minimum credits required for PhD degree is 18 plus 12 credits of PhD thesis Students in PhD program are required to pass a qualifying examination before the end of the third year in the program The PhD candidate shall complete and defend hisher thesis as well as present the thesis work in public

2

Table of Contents

吳 文 騰 Wen-Teng Wu 3

陳 志 勇 Chuh-Yuan Chen 5

楊 毓 民 Yu-Min Yang 7

劉 瑞 祥 Jui-Hsiang Liu 9

鍾 賢 龍 Shyan-Lung Chung 11

溫 添 進 Ten-Chin Wen 13

陳 雲 Yun Chen 15

郭 炳 林 Ping-Lin Kuo 17

吳 逸 謨 Eamor M Woo 19

陳 進 成 Chin-Cheng Chen 21

張 玨 庭 Chuei-Tin Chang 23

黃 世 宏 Shyh-Hong Hwang 25

洪 昭 南 Frankin Chau-Nan Hong 27

許 梅 娟 Mei-Jywan Syu 29

鄧 熙 聖 Hsisheng Teng 31

張 鑑 祥 Chien-Hsiang Chang 33

王 紀 Chai Wang 35

張 嘉 修 Jo-Shu Chang 37

林 睿 哲 Jui-Che Lin 39

陳 東 煌 Dong-Hwang Chen 41

陳 慧 英 Huey-Ing Chen 43

李 玉 郎 Yuh-Lang Lee 45

楊 明 長 Ming-Chang Yang 47

吳 季 珍 Jjih-Jen Wu 49

陳 炳 宏 Bing-Hung Chen 51

黃 耀 輝 Yao-Hui Huang 53

吳 煒 Wei Wu 55

鄭 智 元 Chu-Yuan Cheng 57

魏 憲 鴻 Wei-Hsien Hung 59

侯 聖 澍 Sheng-Shu Hou 61

莊 怡 哲 Yi-Je Juang 63

羅 介 聰 Chieh-Tsung Lo 65

詹 正 雄 Jeng-Shiung Jan 67

王 翔 郁 Hsiang-Yu Angie Wang 69

陳 美 瑾 Mei-Chin Chen 71

吳 文 中 Wen-Chung Wu 73

林 建 功 Chien-Kung Lin 75

3

Studies on lipid production from microalgae

Nannochloropsis oculata The proposed photo-bioreactor

Batch culture at different urea concentrations Semi-continuous cultivatoin

Immobilization of cellulase for hydrolysis the cell wall of microalgae

Wen-Teng Wu (吳文騰教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1968

MS Chemical Engineering National Cheng

Kung University Taiwan

1970

PhD Chemical Engineering National Cheng

Kung University Taiwan

1975

Email wtwumailnckuedutw

Tel 06-2757575-62001

Office Room 93915 Chemical Engineering Building

4

Electrospinning Reactor

Immobilization time (min)

20 40 60 80 100 120 140

Prot

ein

load

ing

(mg

prot

ein

g m

ater

ial)

0

20

40

60

80

100

120

140

Rel

ativ

e sp

ecif

ic a

ctiv

ity

()

0

20

40

60

80

100

120

Time (hr)

0 20 40 60 80 100

Con

cent

rati

on o

f re

duci

ng s

ugar

(g

L)

10

15

20

25

30

35

Effect of enzyme concentration Time course of cellulase to

on protein loading and relative specific hydrolysis the cell wall of microalgae activity

Immobilization of Lipase on Chitosan PVA Electrospinning membrane for Biodiesel Production

SEM photograph of the electrospun chitosan fibers

3wt chitosan PVA PVA

5wt chitosan PVA 5wt chitosan PVA with

1MNaOH treatment

5

Chuh-Yung Chen (陳志勇)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1981

MS Chemical Engineering National

Cheng Kung University Taiwan

1977

PhD Chemical Engineering National

Cheng Kung University Taiwan

1975

Email ccy7ccmailnckuedutw

Tel (06)-2757575 - 62643

Office Room 93B15 Chemical Engineering Building

6

Materials for Green Energy Technology Functional Polymers

CNT Nanocomposite Living Polymerization

Electrospinning

7

Nano-Colloidal Domain - where physics chemistry biology and technology meet

Recent developments in many modern nano-technologies involve new materials or

processes in which interfaces (or surfaces) and colloids play a crucial role They reveal the

interaction of a spectrum of disciplines in which physics chemistry biology and technology

intersect Understanding and utilizing the special properties of molecules at interfaces constitutes

goal of our research These include some of the themes in nano-colloid science self-assembly

construction of supramolecular architecture nanoconfinement and compartmentalization

superhydrophobic superhydrophilic surface patterning and adsorption at nanocystalline surface

A few of our current research topics which exemplify the breadth of our interests follows

Preparation of catanionic vesicles and its applications in drug and gene delivery

Novel liposome-like vesicular systems as carriers

for drug and gene delivery

Time (hr)

01 1 10 100 1000

Rel

ease

(

)

0

20

40

60

80

100

5 EtOH10 EtOH20 EtOH30 EtOH

10mM DeTMA-TS + 10mM CHOL

Surface Science and Engineering Nano-Colloid Lab Research Group

Yu-Min Yang (楊毓民教授)

Professor BS Chemical Engineering Tatung

Institute of Technology Taiwan

1977

MS Chemical Engineering National

Cheng Kung University Taiwan

1979

PhD Chemical Engineering National

Cheng Kung University Taiwan

1983

8

Creation of multifunctional surfaces by using layer-by-layer assembly strategy

By means of Langmuir-Blodgett deposition electrostatic assembly and self assembly nanoparticulate thin films with high transmittance superhydrophobicity superhydropholicity and photocatalysis characteristics can be fabricated for potential applications in self-cleaning microfluidics and biomedical materials

Mixed and sequential adsorption of dye sensitizers on nanocrystalline photoelectrodes of dye sensitized solar cells (DSSCs)

Molecular co-sensitizaton of organic dyes for DSSCs by dye cocktails and bandgap cascade approaches

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

2

Table of Contents

吳 文 騰 Wen-Teng Wu 3

陳 志 勇 Chuh-Yuan Chen 5

楊 毓 民 Yu-Min Yang 7

劉 瑞 祥 Jui-Hsiang Liu 9

鍾 賢 龍 Shyan-Lung Chung 11

溫 添 進 Ten-Chin Wen 13

陳 雲 Yun Chen 15

郭 炳 林 Ping-Lin Kuo 17

吳 逸 謨 Eamor M Woo 19

陳 進 成 Chin-Cheng Chen 21

張 玨 庭 Chuei-Tin Chang 23

黃 世 宏 Shyh-Hong Hwang 25

洪 昭 南 Frankin Chau-Nan Hong 27

許 梅 娟 Mei-Jywan Syu 29

鄧 熙 聖 Hsisheng Teng 31

張 鑑 祥 Chien-Hsiang Chang 33

王 紀 Chai Wang 35

張 嘉 修 Jo-Shu Chang 37

林 睿 哲 Jui-Che Lin 39

陳 東 煌 Dong-Hwang Chen 41

陳 慧 英 Huey-Ing Chen 43

李 玉 郎 Yuh-Lang Lee 45

楊 明 長 Ming-Chang Yang 47

吳 季 珍 Jjih-Jen Wu 49

陳 炳 宏 Bing-Hung Chen 51

黃 耀 輝 Yao-Hui Huang 53

吳 煒 Wei Wu 55

鄭 智 元 Chu-Yuan Cheng 57

魏 憲 鴻 Wei-Hsien Hung 59

侯 聖 澍 Sheng-Shu Hou 61

莊 怡 哲 Yi-Je Juang 63

羅 介 聰 Chieh-Tsung Lo 65

詹 正 雄 Jeng-Shiung Jan 67

王 翔 郁 Hsiang-Yu Angie Wang 69

陳 美 瑾 Mei-Chin Chen 71

吳 文 中 Wen-Chung Wu 73

林 建 功 Chien-Kung Lin 75

3

Studies on lipid production from microalgae

Nannochloropsis oculata The proposed photo-bioreactor

Batch culture at different urea concentrations Semi-continuous cultivatoin

Immobilization of cellulase for hydrolysis the cell wall of microalgae

Wen-Teng Wu (吳文騰教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1968

MS Chemical Engineering National Cheng

Kung University Taiwan

1970

PhD Chemical Engineering National Cheng

Kung University Taiwan

1975

Email wtwumailnckuedutw

Tel 06-2757575-62001

Office Room 93915 Chemical Engineering Building

4

Electrospinning Reactor

Immobilization time (min)

20 40 60 80 100 120 140

Prot

ein

load

ing

(mg

prot

ein

g m

ater

ial)

0

20

40

60

80

100

120

140

Rel

ativ

e sp

ecif

ic a

ctiv

ity

()

0

20

40

60

80

100

120

Time (hr)

0 20 40 60 80 100

Con

cent

rati

on o

f re

duci

ng s

ugar

(g

L)

10

15

20

25

30

35

Effect of enzyme concentration Time course of cellulase to

on protein loading and relative specific hydrolysis the cell wall of microalgae activity

Immobilization of Lipase on Chitosan PVA Electrospinning membrane for Biodiesel Production

SEM photograph of the electrospun chitosan fibers

3wt chitosan PVA PVA

5wt chitosan PVA 5wt chitosan PVA with

1MNaOH treatment

5

Chuh-Yung Chen (陳志勇)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1981

MS Chemical Engineering National

Cheng Kung University Taiwan

1977

PhD Chemical Engineering National

Cheng Kung University Taiwan

1975

Email ccy7ccmailnckuedutw

Tel (06)-2757575 - 62643

Office Room 93B15 Chemical Engineering Building

6

Materials for Green Energy Technology Functional Polymers

CNT Nanocomposite Living Polymerization

Electrospinning

7

Nano-Colloidal Domain - where physics chemistry biology and technology meet

Recent developments in many modern nano-technologies involve new materials or

processes in which interfaces (or surfaces) and colloids play a crucial role They reveal the

interaction of a spectrum of disciplines in which physics chemistry biology and technology

intersect Understanding and utilizing the special properties of molecules at interfaces constitutes

goal of our research These include some of the themes in nano-colloid science self-assembly

construction of supramolecular architecture nanoconfinement and compartmentalization

superhydrophobic superhydrophilic surface patterning and adsorption at nanocystalline surface

A few of our current research topics which exemplify the breadth of our interests follows

Preparation of catanionic vesicles and its applications in drug and gene delivery

Novel liposome-like vesicular systems as carriers

for drug and gene delivery

Time (hr)

01 1 10 100 1000

Rel

ease

(

)

0

20

40

60

80

100

5 EtOH10 EtOH20 EtOH30 EtOH

10mM DeTMA-TS + 10mM CHOL

Surface Science and Engineering Nano-Colloid Lab Research Group

Yu-Min Yang (楊毓民教授)

Professor BS Chemical Engineering Tatung

Institute of Technology Taiwan

1977

MS Chemical Engineering National

Cheng Kung University Taiwan

1979

PhD Chemical Engineering National

Cheng Kung University Taiwan

1983

8

Creation of multifunctional surfaces by using layer-by-layer assembly strategy

By means of Langmuir-Blodgett deposition electrostatic assembly and self assembly nanoparticulate thin films with high transmittance superhydrophobicity superhydropholicity and photocatalysis characteristics can be fabricated for potential applications in self-cleaning microfluidics and biomedical materials

Mixed and sequential adsorption of dye sensitizers on nanocrystalline photoelectrodes of dye sensitized solar cells (DSSCs)

Molecular co-sensitizaton of organic dyes for DSSCs by dye cocktails and bandgap cascade approaches

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

3

Studies on lipid production from microalgae

Nannochloropsis oculata The proposed photo-bioreactor

Batch culture at different urea concentrations Semi-continuous cultivatoin

Immobilization of cellulase for hydrolysis the cell wall of microalgae

Wen-Teng Wu (吳文騰教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1968

MS Chemical Engineering National Cheng

Kung University Taiwan

1970

PhD Chemical Engineering National Cheng

Kung University Taiwan

1975

Email wtwumailnckuedutw

Tel 06-2757575-62001

Office Room 93915 Chemical Engineering Building

4

Electrospinning Reactor

Immobilization time (min)

20 40 60 80 100 120 140

Prot

ein

load

ing

(mg

prot

ein

g m

ater

ial)

0

20

40

60

80

100

120

140

Rel

ativ

e sp

ecif

ic a

ctiv

ity

()

0

20

40

60

80

100

120

Time (hr)

0 20 40 60 80 100

Con

cent

rati

on o

f re

duci

ng s

ugar

(g

L)

10

15

20

25

30

35

Effect of enzyme concentration Time course of cellulase to

on protein loading and relative specific hydrolysis the cell wall of microalgae activity

Immobilization of Lipase on Chitosan PVA Electrospinning membrane for Biodiesel Production

SEM photograph of the electrospun chitosan fibers

3wt chitosan PVA PVA

5wt chitosan PVA 5wt chitosan PVA with

1MNaOH treatment

5

Chuh-Yung Chen (陳志勇)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1981

MS Chemical Engineering National

Cheng Kung University Taiwan

1977

PhD Chemical Engineering National

Cheng Kung University Taiwan

1975

Email ccy7ccmailnckuedutw

Tel (06)-2757575 - 62643

Office Room 93B15 Chemical Engineering Building

6

Materials for Green Energy Technology Functional Polymers

CNT Nanocomposite Living Polymerization

Electrospinning

7

Nano-Colloidal Domain - where physics chemistry biology and technology meet

Recent developments in many modern nano-technologies involve new materials or

processes in which interfaces (or surfaces) and colloids play a crucial role They reveal the

interaction of a spectrum of disciplines in which physics chemistry biology and technology

intersect Understanding and utilizing the special properties of molecules at interfaces constitutes

goal of our research These include some of the themes in nano-colloid science self-assembly

construction of supramolecular architecture nanoconfinement and compartmentalization

superhydrophobic superhydrophilic surface patterning and adsorption at nanocystalline surface

A few of our current research topics which exemplify the breadth of our interests follows

Preparation of catanionic vesicles and its applications in drug and gene delivery

Novel liposome-like vesicular systems as carriers

for drug and gene delivery

Time (hr)

01 1 10 100 1000

Rel

ease

(

)

0

20

40

60

80

100

5 EtOH10 EtOH20 EtOH30 EtOH

10mM DeTMA-TS + 10mM CHOL

Surface Science and Engineering Nano-Colloid Lab Research Group

Yu-Min Yang (楊毓民教授)

Professor BS Chemical Engineering Tatung

Institute of Technology Taiwan

1977

MS Chemical Engineering National

Cheng Kung University Taiwan

1979

PhD Chemical Engineering National

Cheng Kung University Taiwan

1983

8

Creation of multifunctional surfaces by using layer-by-layer assembly strategy

By means of Langmuir-Blodgett deposition electrostatic assembly and self assembly nanoparticulate thin films with high transmittance superhydrophobicity superhydropholicity and photocatalysis characteristics can be fabricated for potential applications in self-cleaning microfluidics and biomedical materials

Mixed and sequential adsorption of dye sensitizers on nanocrystalline photoelectrodes of dye sensitized solar cells (DSSCs)

Molecular co-sensitizaton of organic dyes for DSSCs by dye cocktails and bandgap cascade approaches

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

4

Electrospinning Reactor

Immobilization time (min)

20 40 60 80 100 120 140

Prot

ein

load

ing

(mg

prot

ein

g m

ater

ial)

0

20

40

60

80

100

120

140

Rel

ativ

e sp

ecif

ic a

ctiv

ity

()

0

20

40

60

80

100

120

Time (hr)

0 20 40 60 80 100

Con

cent

rati

on o

f re

duci

ng s

ugar

(g

L)

10

15

20

25

30

35

Effect of enzyme concentration Time course of cellulase to

on protein loading and relative specific hydrolysis the cell wall of microalgae activity

Immobilization of Lipase on Chitosan PVA Electrospinning membrane for Biodiesel Production

SEM photograph of the electrospun chitosan fibers

3wt chitosan PVA PVA

5wt chitosan PVA 5wt chitosan PVA with

1MNaOH treatment

5

Chuh-Yung Chen (陳志勇)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1981

MS Chemical Engineering National

Cheng Kung University Taiwan

1977

PhD Chemical Engineering National

Cheng Kung University Taiwan

1975

Email ccy7ccmailnckuedutw

Tel (06)-2757575 - 62643

Office Room 93B15 Chemical Engineering Building

6

Materials for Green Energy Technology Functional Polymers

CNT Nanocomposite Living Polymerization

Electrospinning

7

Nano-Colloidal Domain - where physics chemistry biology and technology meet

Recent developments in many modern nano-technologies involve new materials or

processes in which interfaces (or surfaces) and colloids play a crucial role They reveal the

interaction of a spectrum of disciplines in which physics chemistry biology and technology

intersect Understanding and utilizing the special properties of molecules at interfaces constitutes

goal of our research These include some of the themes in nano-colloid science self-assembly

construction of supramolecular architecture nanoconfinement and compartmentalization

superhydrophobic superhydrophilic surface patterning and adsorption at nanocystalline surface

A few of our current research topics which exemplify the breadth of our interests follows

Preparation of catanionic vesicles and its applications in drug and gene delivery

Novel liposome-like vesicular systems as carriers

for drug and gene delivery

Time (hr)

01 1 10 100 1000

Rel

ease

(

)

0

20

40

60

80

100

5 EtOH10 EtOH20 EtOH30 EtOH

10mM DeTMA-TS + 10mM CHOL

Surface Science and Engineering Nano-Colloid Lab Research Group

Yu-Min Yang (楊毓民教授)

Professor BS Chemical Engineering Tatung

Institute of Technology Taiwan

1977

MS Chemical Engineering National

Cheng Kung University Taiwan

1979

PhD Chemical Engineering National

Cheng Kung University Taiwan

1983

8

Creation of multifunctional surfaces by using layer-by-layer assembly strategy

By means of Langmuir-Blodgett deposition electrostatic assembly and self assembly nanoparticulate thin films with high transmittance superhydrophobicity superhydropholicity and photocatalysis characteristics can be fabricated for potential applications in self-cleaning microfluidics and biomedical materials

Mixed and sequential adsorption of dye sensitizers on nanocrystalline photoelectrodes of dye sensitized solar cells (DSSCs)

Molecular co-sensitizaton of organic dyes for DSSCs by dye cocktails and bandgap cascade approaches

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

5

Chuh-Yung Chen (陳志勇)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1981

MS Chemical Engineering National

Cheng Kung University Taiwan

1977

PhD Chemical Engineering National

Cheng Kung University Taiwan

1975

Email ccy7ccmailnckuedutw

Tel (06)-2757575 - 62643

Office Room 93B15 Chemical Engineering Building

6

Materials for Green Energy Technology Functional Polymers

CNT Nanocomposite Living Polymerization

Electrospinning

7

Nano-Colloidal Domain - where physics chemistry biology and technology meet

Recent developments in many modern nano-technologies involve new materials or

processes in which interfaces (or surfaces) and colloids play a crucial role They reveal the

interaction of a spectrum of disciplines in which physics chemistry biology and technology

intersect Understanding and utilizing the special properties of molecules at interfaces constitutes

goal of our research These include some of the themes in nano-colloid science self-assembly

construction of supramolecular architecture nanoconfinement and compartmentalization

superhydrophobic superhydrophilic surface patterning and adsorption at nanocystalline surface

A few of our current research topics which exemplify the breadth of our interests follows

Preparation of catanionic vesicles and its applications in drug and gene delivery

Novel liposome-like vesicular systems as carriers

for drug and gene delivery

Time (hr)

01 1 10 100 1000

Rel

ease

(

)

0

20

40

60

80

100

5 EtOH10 EtOH20 EtOH30 EtOH

10mM DeTMA-TS + 10mM CHOL

Surface Science and Engineering Nano-Colloid Lab Research Group

Yu-Min Yang (楊毓民教授)

Professor BS Chemical Engineering Tatung

Institute of Technology Taiwan

1977

MS Chemical Engineering National

Cheng Kung University Taiwan

1979

PhD Chemical Engineering National

Cheng Kung University Taiwan

1983

8

Creation of multifunctional surfaces by using layer-by-layer assembly strategy

By means of Langmuir-Blodgett deposition electrostatic assembly and self assembly nanoparticulate thin films with high transmittance superhydrophobicity superhydropholicity and photocatalysis characteristics can be fabricated for potential applications in self-cleaning microfluidics and biomedical materials

Mixed and sequential adsorption of dye sensitizers on nanocrystalline photoelectrodes of dye sensitized solar cells (DSSCs)

Molecular co-sensitizaton of organic dyes for DSSCs by dye cocktails and bandgap cascade approaches

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

6

Materials for Green Energy Technology Functional Polymers

CNT Nanocomposite Living Polymerization

Electrospinning

7

Nano-Colloidal Domain - where physics chemistry biology and technology meet

Recent developments in many modern nano-technologies involve new materials or

processes in which interfaces (or surfaces) and colloids play a crucial role They reveal the

interaction of a spectrum of disciplines in which physics chemistry biology and technology

intersect Understanding and utilizing the special properties of molecules at interfaces constitutes

goal of our research These include some of the themes in nano-colloid science self-assembly

construction of supramolecular architecture nanoconfinement and compartmentalization

superhydrophobic superhydrophilic surface patterning and adsorption at nanocystalline surface

A few of our current research topics which exemplify the breadth of our interests follows

Preparation of catanionic vesicles and its applications in drug and gene delivery

Novel liposome-like vesicular systems as carriers

for drug and gene delivery

Time (hr)

01 1 10 100 1000

Rel

ease

(

)

0

20

40

60

80

100

5 EtOH10 EtOH20 EtOH30 EtOH

10mM DeTMA-TS + 10mM CHOL

Surface Science and Engineering Nano-Colloid Lab Research Group

Yu-Min Yang (楊毓民教授)

Professor BS Chemical Engineering Tatung

Institute of Technology Taiwan

1977

MS Chemical Engineering National

Cheng Kung University Taiwan

1979

PhD Chemical Engineering National

Cheng Kung University Taiwan

1983

8

Creation of multifunctional surfaces by using layer-by-layer assembly strategy

By means of Langmuir-Blodgett deposition electrostatic assembly and self assembly nanoparticulate thin films with high transmittance superhydrophobicity superhydropholicity and photocatalysis characteristics can be fabricated for potential applications in self-cleaning microfluidics and biomedical materials

Mixed and sequential adsorption of dye sensitizers on nanocrystalline photoelectrodes of dye sensitized solar cells (DSSCs)

Molecular co-sensitizaton of organic dyes for DSSCs by dye cocktails and bandgap cascade approaches

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

7

Nano-Colloidal Domain - where physics chemistry biology and technology meet

Recent developments in many modern nano-technologies involve new materials or

processes in which interfaces (or surfaces) and colloids play a crucial role They reveal the

interaction of a spectrum of disciplines in which physics chemistry biology and technology

intersect Understanding and utilizing the special properties of molecules at interfaces constitutes

goal of our research These include some of the themes in nano-colloid science self-assembly

construction of supramolecular architecture nanoconfinement and compartmentalization

superhydrophobic superhydrophilic surface patterning and adsorption at nanocystalline surface

A few of our current research topics which exemplify the breadth of our interests follows

Preparation of catanionic vesicles and its applications in drug and gene delivery

Novel liposome-like vesicular systems as carriers

for drug and gene delivery

Time (hr)

01 1 10 100 1000

Rel

ease

(

)

0

20

40

60

80

100

5 EtOH10 EtOH20 EtOH30 EtOH

10mM DeTMA-TS + 10mM CHOL

Surface Science and Engineering Nano-Colloid Lab Research Group

Yu-Min Yang (楊毓民教授)

Professor BS Chemical Engineering Tatung

Institute of Technology Taiwan

1977

MS Chemical Engineering National

Cheng Kung University Taiwan

1979

PhD Chemical Engineering National

Cheng Kung University Taiwan

1983

8

Creation of multifunctional surfaces by using layer-by-layer assembly strategy

By means of Langmuir-Blodgett deposition electrostatic assembly and self assembly nanoparticulate thin films with high transmittance superhydrophobicity superhydropholicity and photocatalysis characteristics can be fabricated for potential applications in self-cleaning microfluidics and biomedical materials

Mixed and sequential adsorption of dye sensitizers on nanocrystalline photoelectrodes of dye sensitized solar cells (DSSCs)

Molecular co-sensitizaton of organic dyes for DSSCs by dye cocktails and bandgap cascade approaches

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

8

Creation of multifunctional surfaces by using layer-by-layer assembly strategy

By means of Langmuir-Blodgett deposition electrostatic assembly and self assembly nanoparticulate thin films with high transmittance superhydrophobicity superhydropholicity and photocatalysis characteristics can be fabricated for potential applications in self-cleaning microfluidics and biomedical materials

Mixed and sequential adsorption of dye sensitizers on nanocrystalline photoelectrodes of dye sensitized solar cells (DSSCs)

Molecular co-sensitizaton of organic dyes for DSSCs by dye cocktails and bandgap cascade approaches

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

9

Electro-Optical Polymer Materials Laboratory

Chiral compounds and liquid crystal devices

We are attempting to synthesize a series of novel chiral compounds and photoisomerizable derivatives from camphor These compounds can be used as dopants to adjust the optical properties of liquid crystal devices We have also been investigating the fabrication and characterization of the PSCT cells The pictures on the right show the ONOFF states of PSCT cells fabricated in our lab Brightness enhancement films polarizers and aligning polymers are all our investigation targets

ldquoOFFrdquo state

ldquoONrdquo state

Photoimageable Cholesteric liquid crystal cell

Brightness enhancement liquid crystal film

JUI-HSIANG LIU (劉瑞祥教授)

Professor BS Feng-Chia Univ 197606

MS OSAKA Univ 198103

PhD OSAKA Univ 198403

Email jhliumailnckuedutw

Tel 06-2757575-62646

Office Room 93C11 Chemical Engineering Building

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

10

Inclusion Complexes Linear monomers threaded with

β-cyclodextrin (CD) were found to reveal self assembly properties Fibrous structures could be seen under SEM Highly ordered SAM molecules were confirmed using POM The novel monomer clusters are expected to be used in MEMS to improve the physical properties of the micro devices

Holographic recording Photosensitive polymer was synthesized

and applied in the field of holography Photosensitive refractive index

modulation film The figure above shows the

reproduction of light grating The film was fabricated using photosensitive polymers synthesized in our lab

Gradient refractive index (GRIN) plastic rodsGRIN optical lenses have been used widely in the field of image transmission

systems and high density information transmitting systems We have developed some novel processes for the preparation of GRIN rods The development of novel processes increasing of the refractive index and high numerical aperture (NA) are all our research targets The above left picture shows the inverted image transmitted through a GRIN rod fabricated in our lab The picture on the above right shows the application of rod array on a copy machine

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

11

ON GOING RESEARCH PROJECTS Development of Key Materials and Technologies for Nanocrystalline Photo-Electrochemical Solar Cells Synthesis of High-Performance Phosphor Materials for LED Solid State Lighting Synthesis of Nano-Powder and Nano-Structured Material for Solar-Energy harvesting Process Development for Synthesis of High Thermal Conductivity AlN Powder Microwave Sintering of AlN Substrates for High Power Electronic and Opto-Electronic Applications Process Development for Low Temperature Cofiring AlNCeramic Composites for Microelectronic Applications Process Development for high thermal conductivity AlNPolymer Composites

Development of Materials and Technology for Hot-Repairing of Steel-Making Furnaces A High Thermal Conductivity Materials Developed by LAMSA

AlN powder and sintered specimen synthesized and fabricated by LAMSA

0 10 20 30 40 50 60 70 800

2

4

6

8

10

12

14

16

18

Th

erm

al C

ond

uct

ivity

(W

mK

)

Filler Content (vol)

AlN powder (C) AlN powder (H)

Kanari equation

Thermal conductivities of the sintered AlN specimens and AlNepoxy composites developed by LAMSA

Shyan-Lung Chung Professor

BS Chem Engr National Cheng Kung University

Tainan Taiwan ROC

1977

MS Chem Engr National Taiwan University

Taipei Taiwan ROC

1980

PhD Chem Engr The Johns Hopkins University

Baltimore MD USA

1985

Phone 06-2757575 x62654

Email slchungmailnckuedutw

Office Room 93A16 Chemical Engineering Building

Labs 93A17-20 Laboratory for Advanced Materials Synthesis and

Applications (LAMSA)

microwave sintering microstructure

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

12

Green Compact

AlNglass LTCC and LED chip submount manufactured by LAMSA B Nitride Phosphors Developed by LAMSA Ca2Si5N8Eu

CaAlSiN3Eu

C TiO2 Photocatalyst and Dye-Sensitized Solar Cell Developed by LAMSA

3 0 0 4 0 0 5 0 0 6 0 0 70 0

0 3

0 6

0 9

1 2

1 5

Abs

W a v e le n g th (n m )

S C -T iO2

P 2 5

Absorption spectra of LAMSA TiO2 Degradation capability of LAMSA TiO2

Type of TiO2 Source BET SA (m2g) Band gap eV Voc(V) Jsc(mAcm-2) Fill factor η()

P25 Germany 50 31 076 81 060 370

ST01 Japan 300 32 074 50 064 236

LAMSA-001 NCKU Taiwan 120 27 057 09 057 213

LAMSA-002 NCKU Taiwan 120 29 075 117 058 543

Performance of DSSC fabricated with LAMSA TiO2

LAMSA

P25

W pad

W layer

AlN

Sintered Body

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

13

Modification of anode via self-assembly technique in PLED Influence of hole injection capacity with SAMs in PLEDs

App Phys Lett 2007 Org Eletro 2008

Ten-Chin Wen (溫添進講座教授)

Chair Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1977

MS Chemical Engineering

National Taiwan University Taiwan

1979

PhD Chemical Engineering

Lamar University Texas Taiwan

1986

Email tcwenmailnckuedutw

Tel 06-2385487

Office Room 93913 Chemical Engineering Building

Research filed Organic Light Emitting Diode Plastic Solar Cell

Anode modification of Direct Methanol Fuel Cell

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

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Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

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555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

14

Novel hole transporting layer applying to organic electro-optical device

PLED application Solar cell application

Polymer 2008 J Mater Chem 2008

Anode electrode modification of Direct Methanol Fuel Cell and methanol sensing PlatinumPolyaniline derivative composite electrode

J Power Sources 2007 J Power Sources 2008

PtPDMA PtPSSPAN

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

15

Specialty Polymer Chemistry Electroluminescent Polymers Photoluminescent Chemosensory Polymers Polymeric Nanomaterials

Research Interests

Yun Chen (陳 雲 教授)

Professor BS Chemical Engineering Tunghai University 1972

MS Polymer National Tsing Hua University 1984

PhD Synthetic Chemistry University of Tokyo 1987

Phone 886-6-2757575 ext 62657 886-6-2085843

E-mail yunchenmailnckuedutw

Office Room 93C15 Chemical Engineering Building

Electroluminescent (EL) Copolymers Molecular design of fully-conjugated and isolated electroluminescent copolymers preparation

and characterization electrochemical properties and fabrication of Polymeric Light-Emitting

Diodes (PLED) to investigate their optoelectronic properties

Photoluminescent Chemosensory Compounds and Polymers Molecular design of low MW and polymeric photoluminescent materials with recognition

groups for sensory applications The structures of receptor and transducer are varied to

investigate the sensitivity and selectivity

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

Wavelength (nm)

350 400 450 500 550 600 650 700 750 800

Nor

mal

ized

EL

Int

ents

ity

(au

)

00

02

04

06

08

10

12

White Light

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

16

Applied voltage (V)

0 2 4 6 8L

umin

ance

(cd

m2 )

0

1000

2000

3000

4000

Cur

rent

den

sity

(m

Ac

m2 )

0

100

200

300

400

500

600

P1 V-LP1 V-I

R1= hexyl

R2= oxadiazole

R1 R1

R1R1

R1

R1R2

R2

x

y

z

R2

R2 R2

(I0-

I)I 0

-010

-005

000

005

010

015

020

Metal ions

Ge4+ Ru3+ Fe3+ Cu2+ Zn2+ Sb3+ Na+ Cd2+ Ce3+ Ca2+Li+

o088 A

o124 A

o134 A

o136 A

o16 A

o166 A

o18 A

o196 A

o198 A

o204 A

o208 A

Our Members

Hyperbranched Conjugated Polymers for EL Devices Synthesis and characterization of hyperbranched polymers using newly designed monomers

The structure-property relationship of these polymers and the luminescent characteristics of

their PLED devices are studied to elucidate the influence of molecular structures

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

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Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

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MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

17

Polymer electrolytes for fuel cell and Li-ion battery

Ping-Lin Kuo (郭炳林教授)

Professor BS Chemistry National Cheng Kung

University Taiwan

196809 to

197206

MS amp PhD Applied Chemistry Osaka

University Japan

197804 to

198303

Email plkuomailnckuedutw

Tel06-2757575-62658

Office Room 93C07 Chemical Engineering Building

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

18

Nanoparticles and Pt nano-catalysts for DMFC

Silicone and non-silicone type of functional water-soluble polymers

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

19

Research InterestsSpecialty

-Polymer morphology crystallization thermal properties -Polymer blends miscibility

engineering plastics structure-property characterization -Epoxy networks cure kinetics

-Polymers for microelectronics Advanced and nano-composites biodegradable polymers

DMA (molecular relaxation analysis)

FT-IR (molecular structures analysis)

Eamor M Woo (吳逸謨)

Professor (NCKU Endowed Chair) BS Dept Chemical Engineering National

Cheng Kung University Taiwan

MS School of Chemical Engineering Georgia Inst Tech Atlanta GA USA

PhD Dept Chemical Engineering Univ of Texas at Austin Austin TX USA

Postdoc Dept ChE Univ of Washington Seattle WA USA

Email emwoomailnckuedutw

Tel06-275 7575 ext 62670

Office Room 93B13 Chemical Engineering Building

1800 1760 1720 1680 1640

Wavenumber (cm-1)

Abs

orba

nce

(off

set

scal

e)

neat PEA

9010

8020

7030

6040

4060

3070

2080

neat TA

1090

1737

(B)

gtC=O

1718C=O stretching of TA

C=O stretching region

3800 3600 3400 3200 3000

Wavenumber (cm-1)

Ab

sorb

ance

(of

fset

sca

le)

neat PEA

90108020

7030

6040

5050

4060

3070

2080

1090

neat TA

(A) OH-stretching

3360 3216free hydroxyl groups

inter-associated hydroxyl groups

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

0 100 200 300 400

Temperature(oC)

1E+005

1E+006

1E+007

1E+008

1E+009

1E+010

E(

Pa)

E(

Pa)

0

01

02

03

04

05

tan

BTDA PI film (as-prepared sample)

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

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111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

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111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

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333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

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29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

20

X-Ray diffractometer (crystal structures determination)

OpticalAtomic-Force microscopes etc (Morphology)

growing direction

POM = dark POM = bright

growing direction

POM = dark POM = bright

Differential scanning calorimeter (Thermal analysis)

PEOPHBPLLA=303535

Tmax=190oC Tc=100oC

5 10 15 20 25 30 35

2(degree)

Inte

nsit

y (a

u)

70oC 12hr

60oC 4hr

50oC 2hr

40oC 2hr

158

176

214

230

PHepT melt-crystallized at various temperatures with Tmax=150oC

10 15 20 25 30 35

2 (degree)

Inte

nsit

y (a

u)

WAXD patterns of PHepT melt-crystallized at various temperatures with Tmax=110oC

Tc=35oC

Tc=45oC

Tc=55oC

Tc=65oC

Tc=70oC

200

220

243

10 15 20 25 30 35

2 (degree)In

tens

ity (

au

)

200

220243

Tmax=100oC

Tmax=120oC

176

Tmax=150oC

Tmax=110oC

Tmax=130oC

Tmax=140oC

158

214

230

Poly(3‐hydroxybutyrate)

Tmax=220oC Tc=25oC

50m

Poly(nonamethylene terephthalate)

Tc=70oC

60 70 80 90 100 110Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

Tmax=

140oC

130oC

110oC

100oC

150oC

120oC

Tc=55oC

P1 P2

P1+P1

P2+P3

P2

P1

P2+P3

PHepT

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLA

0 50 100 150 200

1000

1090

PMMA(Mw=53500)PLLA=0100

Temperature (oC)

End

othe

rmic

Hea

t Flo

w (

offs

et s

cale

)

9010802070306040

5050

4060

3070

2080

PMMA1PLLAPMMA-100kPLLA

=0100

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

21

The phenomena of nucleation of vapor on chargedneutral nanoparticles

Chin-Cheng Chen Professor PhD Johns Hopkins University 1979-1985

MS National Cheng Kung University 1977-1979

BS National Cheng Kung University 1973-1977

Email ccchenmailnckuedutw

Tel 06-2757575-62655

Office Chemical Engineering Building

Room 93A15

The size distribution of nanoparticle by the

electrospray system

The effect of charge on the

supersaturation required for the

heterogeneous nucleation of water

on SiO2 nanoparticles

The figure for Electrospray

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

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222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

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444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

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555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

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FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

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222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

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333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

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444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

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29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

22

Ⅱ-Ⅵ Light emitting semiconducting thin film

Preparation of CdS and CdS-Cu Semiconductor Thin Film

Semiconductor thin film gas sensor

CdSCuCdS thin‐film diode

co‐evaporation method spin‐coating method thermal evaporation

SEM photography of the surface morphology for Ga2O3 that oxidizing with water vapor

( (

Schematic illustration of heat treatment

SEM images of CdS thin film for fixed heat

treatment time at (a)as-prepared (b)100(c)

200(d) 300(e) 500

SEM images of CdS thin film at fixed heat

treatment temperature for (a)as-prepared

(b)30min (c)60min (d)90min (e)120min

SEM images of the surface of Cu-CdS film

deposited by spin-coating

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

23

Process Synthesis and Design Our researches are mostly concerned with the design of optimal

structures for water-using networks heat recovery and utility systems in chemical processes In

recent years we are also interested in developing (1) design and maintenance strategies for

control and instrumentation systems in industrial plants (2) process integration methods for

waste minimization and cleaner production and (3) optimal scheduling strategies for batch

azeotropic distillation networks

Process Safety Assessment The main thrust of our effort is to automate several widely-adopted

safety assessment procedures We have successfully integrated FTAFMEAHAZOP into a

digraph-based generic software Recently we also have developed mathematical programs for

designing multi-layer protective systems with optimal maintenance schedules

Batch azeotropic distillation network Ethanol-water-toluene system State-Task Network represents the order

of operation (left) Operating line represents the mass balance and process condition (right)

Chuei-Tin Chang (張玨庭 教授)

Professor BS National Taiwan University Taipei City 1976

MS Columbia University New York City 1979

PhD Columbia University New York City 1982

Email ctchangmailnckuedutw

Tel +886-6-275-7575 ext 62663

Office Room 93611 Chemical Engineering Building

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

24

Fault Detection and Diagnosis These issues are critical in enhancing operational safety in

chemical plants Our interests are diversified eg (1) the application of EKF neural network

fuzzy logic and digraph in fault diagnosis (2) the synthesis of optimal alarm logics and (3) the

development of multi-variate run rules for statistical process control etc

Supply Chain Management The management of a large network of interconnected production

and transportation units is an important issue for the petrochemical industries In recent years

we have developed a generic mixed-integer linear program (MILP) to synthesize the best

multi-period planning strategy for any given petroleum supply chain to satisfy the specified

supplies and demands

Fault evolution sequences Flow diagram of a single-tank storage system with feed-forward level-control loop

(left) The corresponding SDG model (right)

Supply chain in petrochemical industries A typical single-train BTX supply chain

Multilayer protective systems General framework of a protected process (left) A CSTR with multilayer

protective system (right)

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

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(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

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444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

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555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

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FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

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333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

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TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

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555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

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29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

25

Shyh-Hong Hwang (黃世宏教授)

Professor BS Chemical Engineering National

Taiwan University

1980

MS Chemical Engineering Kansas State

University USA

1984

PhD Chemical Engineering University of

Houston USA

1987

E-mail shhwangmailnckuedutw

Tel 886-6-2757575 ext 62661

Office Room 93812 Chemical Engineering Building

Process Control Process Systems Engineering Modeling and Control of Microsystems Microfluidic Transport

Identification and Monitoring of Stochastic Systems

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(a)

Par

am

ete

r e

stim

ate

s

Sample number

-2

-15

-1

-05

0

05

1

15

0 100 200 300 400 500

(b)

Pa

ram

ete

r e

stim

ate

s

Sample number Real-time estimation results for a second-order process under feedback control by (a) the proposed on-line

algorithm (b) the recursive AFCLOE method (Ind Eng Chem Res 2008)

-03

-02

-01

0

01

02

03

04

05

0 25 50 75 100

(a)

UCL

LCL

EW

MA

of v

(k)

Sample number

-015

-01

-005

0

005

01

015

02

0 25 50 75 100 125 150

(b)

EW

MA

of x

(k)

Sample number

UCL

LCL

Monitoring of a second-order process based on EWMA control charts of (a) noise v(k) (b) prediction errors x(k)

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

26

0

02

04

06

08

1

12

14

0 20 40 60 80 100

(a)

Actual steady-state curveMethod of Harris et alHammerstein identificationWiener identification

CB

F

Critical operation point

06

08

1

12

14

16

18

2

0 01 02 03 04 05

(b)

Actual responseHammerstein predictionWiener predictionLinear prediction

CB

Time Identification results of a CSTR (a) approximations of the steady-state curve (b) model predictions versus the

actual response to step-input changes (Ind Eng Chem Res 2009)

Facilitated particle trapping at the stagnation point due to an attractive non-divergence-free force from the

bottom surface

Particle sorting by mobility via a limit cycle trap (Physical Review E 2010)

Experimental setup for microfluidic chips

Particle assembly observed in a micro-electrode design

Nonlinear Identification and Control

Dynamic Particle Trapping Release and Sorting by Micro-Vortices

Particle Assembly in Microfluidic Systems

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

27

NNNaaannnooodddeeevvviiiccceee---FFFaaabbbrrriiicccaaatttiiiooonnn TTTeeeccchhhnnnooolllooogggiiieeesss

(((OOOppptttooo---)))EEEllleeeccctttrrrooonnniiicccsss aaannnddd IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 LLLaaarrrgggeee---AAArrreeeaaa FFFlllaaattt PPPaaannneeelll DDDiiisssppplllaaayyy NNNaaannnooowwwiiirrreee TTTrrraaannnsssiiissstttooorrrsss

((HHiigghh MMoobbiilliittyy AAttmmoosspphheerriicc MMaannuuffaaccttuurree TTrraannssppaarreenntt))

222 NNNaaannnooowwwiiirrreee LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeeesss

((LLooww CCoosstt RRoobbuusstt LLaarrggee AArreeaa))

333 LLLiiiggghhhttt---EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDiiisssppplllaaayyysss

((UUllttiimmaattee DDiissppllaayyss ndashndash LLoonngg LLiiffee HHiigghh BBrriigghhttnneessss VVeerryy TThhiinn))

333 FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss

((RRFFIIDD EE--PPaappeerr FFlleexxiibbllee DDiissppllaayyss eettcc))

444 NNNaaannnooowwwiiirrreee SSSooolllaaarrr CCCeeellllllsss

((RRoobbuusstt HHiigghh EEffffiicciieennccyy CChheeaapp GGrreeeenn))

555 OOOppptttoooeeellleeeccctttrrrooonnniiiccc IIInnnttteeegggrrraaattteeeddd CCCiiirrrcccuuuiiitttsss (((OOOEEEIIICCC)))

((CCoommbbiinnaattiioonn ooff IIIIII--VV ((IInnGGaaNN)) aanndd SSii iinn aa ssiinnggllee cchhiipp))

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss aaannnddd DDDiiisssppplllaaayyysss TTTeeeccchhhnnnooolllooogggiiieeesss

Franklin Chau-Nan Hong (洪昭南教授)

BS Industrial Chemistry National Tsing Hua University Hsinchu Taiwan

1978

MS Chemical Engineering Northwestern University Evanston IL USA

1981

PhD Chemical Engineering Northwestern University Evanston IL USA

1984

Email hongmailnckuedutw

Tel 886-6-2757575-62662

Office Room 93C16 Chemical Engineering Building

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

28

MMMooobbbiiillleee IIInnnfffooorrrmmmaaatttiiiooonnn IIInnnddduuussstttrrryyy

111 RRRooollllll---tttooo---RRRooollllll PPPrrriiinnntttiiinnnggg TTTeeeccchhhnnnooolllooogggyyy fffooorrr PPPaaatttttteeerrrnnniiinnnggg ooofff

FFFllleeexxxiiibbbllleee DDDeeevvviiiccceeesss ((FFlleexxiibbllee DDiissppllaayyss RRFFIIDD EE--PPaappeerr eettcc))

222 SSSeeelllfff---AAAsssssseeemmmbbblllyyy TTTeeeccchhhnnnooolllooogggyyy fffooorrr SSSeeeaaammmllleeessssss IIImmmppprrriiinnnttt

MMMooolllddd FFFaaabbbrrriiicccaaatttiiiooonnn ((LLooww CCoosstt aanndd EEaassyy FFaabbrriiccaattiioonn))

333 TTTrrraaannnssspppaaarrreeennnttt CCCooonnnddduuuccctttiiivvveee PPPlllaaassstttiiiccc FFFiiilllmmm

((BBeennddaabbllee EEnndduurraabbllee LLooww CCoosstt HHiigghh CCoonndduuccttiivviittyy ampamp

TTrraannssppaarreennccyy))

444 OOOrrrgggaaannniiiccc LLLiiiggghhhttt EEEmmmiiittttttiiinnnggg DDDiiiooodddeee DDDeeevvviiiccceeesss aaannnddd FFFllleeexxxiiibbbllleee

MMMeeemmmooorrryyy DDDeeevvviiiccceeesss ((SSiinnggllee--llaayyeerr OOrrggaanniiccss HHiigghh EEffffiicciieennccyy))

555 AAAnnntttiiirrreeefffllleeeccctttiiivvveee OOOppptttiiicccaaalll FFFiiilllmmmsss aaannnddd BBBiiiooommmiiimmmeeetttiiiccc DDDeeevvviiiccceeesss

PPPlllaaasssmmmaaa TTTeeeccchhhnnnooolllooogggiiieeesss aaannnddd TTThhhiiinnn FFFiiilllmmm DDDeeepppooosssiiitttiiiooonnn

IIInnnfffooorrrmmmaaatttiiiooonnn MMMeeeccchhhaaannniiicccaaalll OOOppptttiiicccsss aaannnddd EEEnnneeerrrgggyyy IIInnnddduuussstttrrriiieeesss

111 AAAtttmmmooosssppphhheeerrriiiccc PPPlllaaasssmmmaaa ((DDeeppoossiittiioonn TTrreeaattmmeenntt ampamp EEttcchhiinngg))

222 NNNooovvveeelll HHHiiiggghhh---DDDeeennnsssiiitttyyy PPPlllaaasssmmmaaa GGGeeennneeerrraaatttiiiooonnn ((LLooww CCoosstt

LLaarrggee AArreeaa aanndd EEaassyy FFaabbrriiccaattiioonn))

333 FFFuuunnnccctttiiiooonnnaaalll TTThhhiiinnn FFFiiilllmmmsss ((SSuuppeerr--ttoouugghh NNaannooccoommppoossiittee FFiillmmss

CCaarrbboonn NNaannoottuubbeess SSiilliiccoonn CCaarrbbiiddee CCuubbiicc BBoorroonn NNiittrriiddee

DDiiaammoonndd--LLiikkee CCaarrbboonn NNaannooddiiaammoonndd eettcc))

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

29550 600 650 700 750 800

0

500

1000

1500

2000

2500

3000

4-methylamino-N-allylnaphthalimide4-bromo-N-allylnaphthalimide4-bromo-18-naphthalic anhydrideblank (DMSO)

Inte

nsity

Wavelength (nm)

Bin

din

g ca

pac

ity

(mg

g M

IP)

00

04

08

12

16

20

Crn Crn CrnCr N P

Crn Cr N P

(I0-

I)I

0

000

002

004

006

008

010

N N‐hydroxysuccinimideP 2‐pyrrolidinone Crn creatinine Cr creatine

Time (s)

5400 6000 6600 7200 7800

Res

pons

e cu

rren

t den

sity

(A

cm

2 )

0

5

10

15

20

25

30Test 1Test 2

Biomaterials and Biosensing Lab The major research topics of this lab are

outlined as follows 1 synthesis modification characterization and

applications of molecularly imprinted materials

2 biosensing chip and system 3 synthesis of biocompatible nanomaterials

for the loading and release of anticancer drugs

4 Biofuel cell system Biocompatible molecularly imprinted materials and biosensing To achieve an ultimate goal of micro biosensing chip system with binding specificity towards the target molecules

0 1000 2000 3000 4000-120

-90

-60

-30

0

30

F (

Hz)

Time (s)

typical QCM signal from the detection of bilirubin

binding of creatinine from MIP in two‐compound mixture

synthesis of fluorescent monomer with high intensity for the preparation of MIP with fluorescene

the fluorescent monomer

Creatinine caused the largest fluorescence quenching

Sensing of bilirubin from the MIP (imprinted poly(AMPS‐co‐EGDMA)) CNTAu electrode sample

solvent

Mei-Jywan Syu (許梅娟教授) Professor

BS Chemical Engineering Purdue University USA

1985

MS Chemical Engineering National Taiwan University Taiwan

1987

PhD Chemical Engineering National Cheng Kung University Taiwan

1991

Email syumeibioenggmailcom Tel 06-2757575-62631 Office Room 93717 7th floor Chemical Engineering Building

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

30

Potential (V)

00 04 08 12 16

Cur

rent

(A

)

-20

0

20

40

60

80

100

5 mVs10 mVs30 mVs50 mVs70 mVs

Scanning rate (mVs)0 20 40 60 80

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

00 01 02 03 04 050

10

20

30

40

Pow

er d

ensi

ty (W

cm

2 )

Operation voltage (V)

Ani o-PD = 81 CNTs

Diameter (nm)

Per

cen

tage

(

)

0

5

10

15

20

25

90 95 100 105 110 115 120

Time (sec)

0 40 80 120 160

Pot

enti

al (

mV

)

-150

-100

-50

0

50

100

150

385 x 10-3 M

122 x 10-3 M

385 x 10-4 M

122 x 10-4 M

385 x 10-5 M

385 x 10-6 M

122 x 10-6 M

Urea concentration (LogM)

-6 -5 -4 -3 -2

Pote

ntia

l cha

nge

(mV

)

0

50

100

150

200

250

calibration liney = 5243x + 320R2 = 09926

Time (day)

5 10 15 20 25 30 35 40 45

Pot

enti

al c

hang

e (m

V)

0

50

100

150

200

Immobilized enzyme electrode for biosensing

Biofuel cell system

Biocompatible nanomaterials for drug loading and release

60 90 120 150 180 210 24000

01

02

03

04

05

Ope

ratio

n vo

ltage

(V

)

Current density (Acm2)

Ani o-PD = 81 CNTs

Rh‐(P3MTGOx) x 10000

polypyrrole nanotubes x 60000

maximum power density of 38 Wcm2 was achieved at current stage

Schematic biofuel cell device

chitosan nanoparticles PLGA microspheres PLGA scaffold x 500 PLGA nanoparticlesx2000

small unilamellar liposome vesicles

bare nanomagnetic particles multilamellar PEG‐DMPE

liposome vesicles multilamellar PEG‐DMPE liposome vesicles

silica oxide coated nanomagnetic particles

Calibration curve Storage of electrode stability

Potentiometric sensing of urea

I‐V curve

CV curves at different scanning rates

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

31

Perovskite‐like NaTaO3 powders obtained from different synthesis methods are different

in their TaOTa bond angle which affects the photoluminescence intensity and the photocatalytic activity in water splitting of NaTaO3

Photocatalysts for Hydrogen Generation from Water Splitting

With instantaneous contact with n‐type WO3 particles electrodeposited derived p‐type Cu2O particles were capable of catalyzing H2 evolution from aqueous solutions under visible‐light illumination

Hsisheng Teng (鄧熙聖 教授)

Professor

BS Chemical Engineering Cheng Kung

University

1984

MS Engineering Brown University 1991

PhD Engineering Brown University 1992

Email htengmailnckuedutw Phone 886-6-2757575-62640 Office Room 93A12 Chemical Engineering Building

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

32

Nanocrystalline TiO2 Films for Dye-sensitized Solar Cells

Nanostructured Carbons for Supercapacitors

A high‐purity and structure intact TiO2 anatase derived from a titanate is used as the

electrode substrate for sensitization and the resulting dye‐sensitized solar cells exhibits a

cell performance Dye‐sensitized solar cells

Trap states resulting the trappingdetrapping process and retard electron transport

Minimization of the defect states of TiO2 films can facilitate electron transport and reduce

electron transit time

Trappingdetrapping process

The larger deviation of coordination number

displays that more trap states exist in TiO2

Sputtering deposition of Ni catalyst particles leads to a uniform growth of CNTs on the carbon fiber surface through the tip‐growth mechanism The performance is examined by using ac impedance spectrum analyzer in an aqueous solution

The SEM image of the CNT‐grafted and bare fiber

The TEM image of the CNT and Ni catalyst

Nyquist impedance plots of the carbon electrode

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

33

‐60 ‐40 ‐20 0 2 4 60

1

2

3

4

5excess

DNA

excess

vesicle

Zeta potential mV

Preparations and applications of charged drug delivery carriers

Catanionic vesicles with reasonable stability and specific charge characteristics are prepared from catanionic

surfactants or ion pair amphiphiles with a proper process in order to be used as drug delivery carriers Moreover

the feasibility of using the stable catanionic vesicles with positive charges in the gene delivery applications is

examined

‐150 ‐100 ‐50 0 5 10 150

5

1

1

2

Intensity

Zeta potential mV Time day1 1 10

Ave size distribution n

m

10

10

10

Intensity

zeta potential and size stability of positively charged catanionic vesicles zeta potentials

of vesicleDNA complexes

Cationic surfactant

Anionicsurfactant

Ion Pair Amphiphile

Catanionicvesicle

Counterions

Negatively

charged DNA

Positively charged catanionic vesicle

Gene delivery applications

+

Chien-Hsiang Chang (張鑑祥教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering

Purdue University

1993

Email changchmailnckuedutw

Tel (+) 886-6-2757575 ext 62671

Fax (+) 886-6-2344496

Office Room 93620 Chemical Engineering Building

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

34

Investigation of mixed lipidprotein layer behavior at airliquid interfaces

Brewster angle microscopy (BAM) and infrared reflection-absorption spectroscopy (IRRAS)

techniques are used to analyze the monolayer morphology and molecular arrangement at

airliquid interfaces in order to investigate the mechanisms involved in the plasma

protein-induced inhibition of the dynamic surface activity of lung surfactant systems

Brewster angle microscopy infrared reflection-absorption spectroscopy Fabrications and applications of ultra-thin films

Langmuir-Blodgett (LB) deposition technique is applied to transfer a monolayer from the

airliquid interface onto a solid substrate in order to fabricate organized monolayer or multilayer

thin films

Applications of electroosmosis in microchannels

By applying an electric field in a microchannel fabricated by polymer or glass an

electroosmotic flow is induced as a driving force to transport samples in the microchannel and is

used to estimate the zeta potentials of the microchannel surfaces with a current monitoring

method

Brewster angle

Principle ndash with p-polarized light

Air

Liquid

Upward

Substrate

LB deposition

AFM image of a LB film

Electroosmotic flow in a microchannel Estimation of zeta potentials of microchannel surfaces

from the induced electroosmotic flow with a current monitoring method

U1

U2

time

0 50 100 150 200

cu

rren

t

06

07

08

09

10

11

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

35

Research interests 1Development of electrospinning process for polymer nanofibers

Chi Wang (王 紀 教授)

Professor BS Chemical Eng National Taiwan

University

1984

MS Chemical Eng National Taiwan

University

1986

PhD Polymer Eng University of Akron

(USA)

1992

Email chiwangmailnckuedutw

Tel 886-6-2757575-62645

Office Room 93621 Chemical Engineering Building

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

36

2Rheological properties of polymer fluids

aT (rads)

10-1 100 101 102 103 104 105 106 107 108 109

G

G

(Pa)

100

101

102

103

104

105

106

107

tan

10-1

100

101

102

103

G G tan

lnaT (rads)

0 5 10 15 20 25

G

(Pa)

x10

-6

0

005

010

015

020

loading (wt)

0 1 2 3 4 5 6 7

G (

Pa)

10-3

10-2

10-1

100

101

reduced mass fraction (m-mcG)mcG

1 10 100G

(P

a)

10-1

100

101

102

rads

01 1 10 100 1000

G

Pa-s

10-3

10-2

10-1

100

101

102

103

13 nylon1phr 5phr3phr 7phr 01 phr

3Morphological features of polymers and polymer nanocomposites

ARES rheometer used in this lab PLA volume fraction dependence of the specific solution viscosity

Master curves of Grsquo Grdquo and tan for PLA

Plot of Grdquo vs log curve for obtaining GN

0 of PLA by integration method

Grsquo of the CNCNylon solutions as a function of CNC loading The inset shows the log-log plot of Grsquo vs reduced mass fraction

Grsquo of CNCNylon solutions with various CNC loadings

Typical morphology for sPSiPS 5050 blend at 300oC observed by OM The inset shows the FFT pattern

TEM micrograph of sPSCNC=955 nanocomposites The inset shows the primary CNC particle with a diameter of ~50 nm

Typical Hv scattering patterns for iPS or sPS observed by small-angle light scattering

TEM micrograph of sPS nanofibers The inset shows the corresponding ED pattern

Small-angle X-ray scattering (SAXS) pattern of sPS with rdquo and rsquocrystal forms

Typical iPS spherulite observed by POM

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

37

Bioenergy production from cellulosic feedstock

Microbial fuel cell

Jo-Shu Chang (張嘉修教授)

Professor BS ChemicalBiochemical Engineering

University of California Irvine USA

1993

MS Chemical Engineering

University of Colorado Boulder USA

1987

PhD Chemical Engineering

Tunghai University Taiwan

1983

Email changjsmailnckuedutw

Tel 06-2757575-62651

Office Room 93816 Chemical Engineering Building

Microalgal energy and CO2 reduction

Biodiesel production

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

38

Biohydrogen integration system without CO2 emission

Biosurfactant production

Applications of biosurfactants on

bioremediation of oil contaminated soil

Heavy metals biosorption and biosensing

Natural anticancer drug

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

39

Jui-Che Lin (林睿哲教授)

BS Chemical Engineering National Cheng Kung University Taiwan

1987

MS ---- 1964

PhD Chemical Engineering University of Wisconsin-Madison USA 1994

Email jclinmailnckuedutw

Tel 886-6-2757575-62665

Office Room 93C16 Chemical Engineering Building

BBiioommaatteerriiaallss BBiioommeeddiiccaall EEnnggiinneeeerriinngg PPhhyyssiiccaall CChheemmiissttrryy ooff PPoollyymmeerr SSuurrffaacceess

The research activities in our laboratory focus mainly in two areas (1) study of the

interactions between the biological environment and biomaterial surface with an aim to

improve materials biocompatibility (2) molecular design synthesis and characterization of

new biocompatible materials or biodegradable polymers

Study of the interactions between the biomaterial surface and proteins or platelets

In order to elucidate the relationships between the biological responses and surface

properties of biomaterials our lab has synthesized a series of novel alkanethiols with various

bio-inspired terminal functional groups to form a self-assembled monolayer (SAM) with

well-defined chemical configuration Various surface analysis techniques such as ATR-FTIR

ESCA AFM and contact angle measurement are utilized to characterize the SAM substrates

In addition several in situ techniques including a home-designed flow cell with ATR-FTIR

analysis capability for semi-quantitative analysis of protein adsorption radioactive tracer

technique and in vitro platelet adhesion assay are employed to study the dynamic

interactions between blood and biomaterials surface

The Chemical Configuration of SAM

Au substrate Ra=37nm

Zmax=336nm SAMs with ndashSO3H terminal

functionality Ra=32nm

Zmax=344nm

Surface group Alkyl or

derivatized-alkyl group

Chemisorption at the

Surface‐active

Interchain van der Waals and

electrostatic interactions

‐OH‐COOH ndashSO3H

‐CH3‐PO3H2

phospholipid

Au

Au

Atomic Force Microscopy

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

40

Synthesis of Novel Biomaterials

Surface immobilization of antithrombogenic biomolecules such as hirudin thrombomodulin

or heparin and surface grafting of various functionalities are performed to improve

materials biocompatibility or blood compatibility In addition a novel polyurtheane is

proposed as a potential candidate for biliary stent application to improving its patency

leading to a reduction in reoccurrence in obstructive jaundice These two projects are closely

cooperated with the clinical and basic medicine professionals

Synthesis and Chemical Modification of Biodegradable Polymer Chitosan

Since chitosan the second most abundant polysaccharide on earth can be safely metabolized

within the human body as well as carry a wide range of bacteriostatic capability our lab has

greatly involved in the synthesis and modification of this novel biomaterial with an aim to

improve its hemocompatibility and its solubility within biosafe organic solvents This effort

has led to a development of novel photocrosslinked drug delivery vehicle and tissue scaffold

Publications

39 papers have been published in peer reviewed international journals

Biliary Stent

Insertion of

Biliary Stent

In vitro Platelet Adhesion Assay

Au control ‐COOH ‐SO3H ‐CH3 ‐OH ‐PO3H2

The SEM micrographs of adhered platelets on SAMs with various terminal functionalities -OH (17plusmn05) lt -CH3 (21plusmn35) lt -PO3H2 (33plusmn11) -SO3H (35plusmn26) lt -COOH (41plusmn33) Au (44plusmn29) (platelets1000mm2)

Gel Chitosan Liquid

UV irradiation

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

41

water-soluble blue photoluminescent Si nanocrystals with oxide surface passivation

Nanoparticles FeAu NiAu Fe3O4

Functional nanoparticles preparation characterization self-assembly and applications

Polymer-coated magnetic nano-adsorbent

Biomoleculedrug-nanoparticle conjugates

Flurescent nanoparticle

high adsorption capacity fast adsorptiondesorption rates can be magnetically manipulated particularly useful for macromolecules recoverable catalyst support

enzyme immobilization bio-detection biolabeling bio-separation drug deliverytargeting - pH-triggered release - two-photo triggered release

Biomoleculesdrugs proteins enzymes DNA drugs

biolabeling two-photo excitation

green photoluminescent Fe2Si nanocrystals

Dong-Hwang Chen (陳東煌 特聘教授)

Distinguished Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1985

PhD Chemical Engineering National

Cheng Kung University Taiwan

1992

Emailchendhmailnckuedutw

Tel06-2757575-62680

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

42

Dual-frequency EM wave absorption of NiAg nanoparticles

SEM images of pure AZO thin film (a) and Ag nanoparticles-containing AZO thin films with AgZn= 005(b) 010 (c) and 015 (d) at

Core-shell and alloy metal nanoparticles

Nanostructured composite films preparation and characterization

Others

Fabrication sol‐gel

dispersioncasting

layer‐by‐layer self assembly

electrophoretically deposition

Applications surface coatingsmodification optical devices (UVVISNIR) optoelectronic devices conducting devices electrochemical devices photocatalytic devices biosensors

Process RampD for nanoparticle‐dispersed functional textile

Membrane separation processes

Solvent extraction and ion exchange

optical amp magnetic properties biomedical gene transfer magnetic targeting therapy conductingEMI filler self-assembly

Low temperature PL spectra of SiSiO2 thin film

2D‐3D superlattice of Fe oxideAu nanoparticles

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

43

Various inorganic Membranes including alumina titania and Pd-based composite membranes

have been developed for uses on gas separation purification and membrane reactor

Pd membrane

N2

H2

1

2

3

1 Dissociative adsorption2 Diffusion3 Associative desorption

Hydrogen permeation through Pd membrane Palladium-based membrane reactor used in the

production of phenol from benzene

Various deposition techniques have been employed to develop semiconductor-type hydrogen

sensors based on Schottky diode and resistivity The key merits of our deposition techniques

are low temperature and low energy The resulting devices demonstrate excellent hydrogen

Inorganic Membranes Laboratory (93826R)

Synthesis and Application of Inorganic Membranes

Fabrication of Hydrogen Sensors

Huey-Ing Chen (陳慧英 教授)

Professor BS Chemical Engineering

National Cheng Kung University Taiwan 1979

MS Chemical Engineering

National Cheng Kung University Taiwan 1981

PhD Chemical Engineering

National Cheng Kung University Taiwan 1994

Email hueyingmailnckuedutw

Tel 886-6-2757575-62667

Office Room 93818 Chemical Engineering Building

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

44

sensing performances with high sensitivity wide detection range and rapid response rate

Multi-gas and multi-functional sensors are currently developed in this laboratory

Hydrogen Sensor

Sensing ComponentsPd Films

AuGe Ohmic Contact

Pd Schottky Contact

GaAs

InP

GaAs

InP

Various kinds of nanoparticles have been developed in this laboratory such as metal (Cu Ni

Pd Ag PdAg) metal oxides (TiO2 CeO2) and semiconductors (CdSe CdTe)The

preparation characterization and application of the nanoparticles are investigated

In order to exploit green and sustainable energy the generation of hydrogen from water via

photoelectrochemical (PEC) reaction has been developed The TiO2Ti-b ased materials are

prepared as photoanodes The photoconversion efficiency is so far estimated up to 20

Solar utilization on Hydrogen Generation

Morphology of TiO2Ti nanotubes

Schematic diagram of PEC system

Photoefficiency curves for

Pt‐TiO2Ti photoelectrodes

Preparation and Application of Nanoparticles

CeO2 nanoparticles (a) needle‐like

(b) particulate

CO oxidation conversion with different

catalysts

(a) (b)

450 500 550 600 650Wavelength (nm)

0

100

200

300

400

500

600

Inte

nsi

ty (

au

)

10min

40min120min240min

360min720min

1080min1440min

Enhancement of PL efficiency of CdSe

nanoparticles

-04 00 04 08 12 16

Eapp (V)

0

4

8

12

16

20

Pho

toco

nve

rsio

n e

ffic

ien

cy

(

)

Pt (0 wt)

Pt (015 wt)

Pt (011 wt)Pt (009 wt)

Pt (003 wt)

Pt (006 wt)

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

0 200 400 600 800 1000 1200 1400

Time (sec)

00

02

04

06

08

10

Cu

rren

t de

nsit

y (m

Ac

m2 ) 0V

05V1VPt(006wt)-TiO2Ti

TiO2Ti

UV-off UV-on UV-off UV-off UV-offUV-off UV-off

Photocurrent response curves for

Pt‐TiO2Ti photoelectrodes

-15 -1 -05 0 05 1 15Applied Voltage (V)

1x10-9

1x10-8

1x10-7

1x10-6

1x10-5

1x10-4

1x10-3

1x10-2

1x10-1

1x100

1x101

1x102

Cu

rren

t D

ensi

ty (

Ac

m2 )

T=423KAir5ppm50ppm100ppm200ppm500ppm1000ppm10000ppm

I‐V characteristic

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

45

Langmuir-Blodgett Film Deposition

Spreading the molecules or particles at airliquid interface compression to an organized

state then transferring to a solid substrate

SiO2 nanoparticles LB film Au nanoparticles LB film

Layer-by-Layer assembly of raspberry-like particulate film

Yuh-Lang Lee (李玉郎 教授)

Professor BS Chemical Engineering National Cheng

Kung University Taiwan

1984

MS Chemical Engineering National Cheng

Kung University Taiwan

1986

PhD Chemical Engineering National Cheng

Kung University Taiwan

1991

Email ylleemailnckuedutw

Tel 06-2757575-62693

Office Room 93612 Chemical Engineering Building

20nm

Barrier

(J colloid Interfacial Sci 2007)

Raspberry-like particulate film on

SAM

Substrate

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

46

Quantum Dots-Sensitized Nanocrystilline Photoelectrodes for DSSC and Water Splitting

In-Situ Scanning Tunneling Microscopy-Electrochemical mode

Raspberry-like particulate film on

SAM

Highly-ordered C60 Monolayer Self-Assembled on Au(111)

HS-C6-OH on Au(111) Complexation of Fullerenes on a Pentacene-Modified Au(111) Surface

(Langmuir 2007)

H2 generation rate220 umolecm2h

(536 ml cm2h)

(Langmuir 2008)

(Nanotechnology 2008) (Chem Mater 2007)

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)ZnSAu

1

23

1 2

3

TiO2CdS(3)CdSe(4)Pt

TiO2CdS(3)CdSe(4)ZnSPtTiO2CdS(3)CdSe(4)ZnSAu

η()422

(Langmuir 2007)

(Adv Fun Mater 2008)

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

47

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

volta

ge (

V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

0 20 40 60 80 100 120 140 160 180 200 2200

5

10

15

20

25

30

35

po

we

r d

ensi

ty (

mW

cm

2)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Proton Exchange Membrane Fuel Cell

cell

Current density (mAcm2)

0 100 200 300 400 500

Vol

tag

e (V

)

00

01

02

03

04

05

06

07

08

09

10

11

12

pure H2

25ppm COH2

100ppm COH2

2 O2 + 100ppm COH2

cathode

anode

Current density (mAcm2)

0 100 200 300 400 500

An

ode

or

Cat

hod

e V

olta

ge

(V)

-01

00

01

02

03

04

05

06

07

08

09

10

11 pure H2(cathode)25ppm COH2(cathode)100ppm COH2(cathode)2O2 + 100ppm COH2(cathode)pure H2(anode)25ppm COH2(anode)100ppm COH2(anode)2O2 + 100ppm COH2(anode)

Direct Methanol Fuel Cell

Mesoporous carbon as the catalyst support

Ming-Chang Yang (楊明長教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1980

MS Chemical Engineering Case Western

Reserve University USA

1984

PhD Chemical Engineering Case Western

Reserve University USA

1990

Email mcyangmailnckuedutw

Tel 06-2757575 ext 62666

Office Room 93908 Chemical Engineering Building

The application of reference electrode during cell discharging

MEA Pt‐RuC

0 20 40 60 80 100 120 140 160 180 200 220 24000

01

02

03

04

05

06

07

08

09

volta

ge

(V)

current density (mAcm2)

Vulcan XC-72 CNT MC5 ETEK JM

Cathode

Anode

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

48

β‐estradiolcholesterol

Various content in mobile phase

β‐estradiolcholesterol

Various temperature

Molecularly Imprinting Polymer

Sol‐gel method for cholesterol‐MIP

00

01

02

03

04

05

06

07

08

09

Non-MIPNon-MIPNon-MIP MIPMIPMIPsol-gelpolymer

hydrogen-bondpolymer

hydrophobicpolymer

cholesterol testosterone

am

oun

t of

adso

rptio

n (m

ole

)

0

200

400

600

800

1000

1200

13000

13500

14000

00

01

02

03

04

05

06

07

[NH4OH]=10-2M

MIP Non-MIP

[NH4OH]=10-4M[HCl]=10

-5M[HCl]=10-4M[HCl]=10

-2M[HCl]=5x10-2M

am

oun

t of a

dso

rptio

n(

mo

le)

Concentration of catalyst in sol-gel solution

-100

IPB

(

)

Suspension polymerization to fabricate Cholesterol‐MIP for Chromatography

Carbon Monoxide Sensors

LaF3 electrolyte for CO and O2 low temperature sensor

Nafion‐base CO sensor

0 50 100 150 200 250

-160

-120

-80

-40

0

20 40

60 80 100

10

Po

tent

ial

mV

Time min

09 11 13 15 17 19 2140

60

80

100

120

140

160

180

200

80 mlmin 70 mlmin 60 mlmin 50 mlmin

Pot

ent

ial d

iffe

ren

ce m

V

log([O2] )

10 μm

18 20 22 24 26 28 3040

50

60

70

80

90

100

sensitivity= 546 mVdecade

Pot

entia

l diff

eren

ce m

V

log([CO] ppm)

0 50 100 150 200 250 300 350 400-200

-180

-160

-140

-120

-100

-80

700 ppm

500 ppm

300 ppm

200 ppm

100 ppm

Pot

entia

l m

V

Time min

Pt

Al2O3

Pt

Au

0 100 200 300 400 500 600 700 800 900 1000 110000

05

10

15

20

25

30

35

40

45

50

S=224

S=336

S=38

S=437 PtSn in N

2

PtSn in Air Pt in N

2

Pt in Air

Cu

rre

nt

CO concentration ppm

0 100 200 300 400 500 600 700 800 900 1000 1100 120000

05

10

15

20

25

30

35

40

S=047

S=100

S=188

S=336

33 RH

58 RH

75 RH

100 RH

Se

nsi

ng

Cu

rre

nt

CO Concentration ppm

30 40 50 60 70 80 90 10000

05

10

15

20

25

30

35

Sen

sitiv

ity n

Ap

pm

Gas relative humidity (RH)

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

49

Jih-Jen Wu (吳季珍教授)

Professor BS Chemical Engineering National

Cheng Kung University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

1997

Emailwujjmailnckuedutw

Tel06-2757575-62694

Office Room 93A08 Chemical Engineering Building

ZnO Nanorods (Adv Mater amp JPCB 2002)

TiO2 Nanorods (JPCB 2004)

One‐Dimensional Semiconductor Nanostructures

ZnO Nanotubes (APL 2002)

nncc--SSiiSSiiOOxx CCoommppoossiittee NNaannoorrooddss ((AAddvv MMaatteerr 22000022 ampamp AAddvv FFuunncctt MMaatteerr 22000055))

ZnO nanorodsZnO film (Adv Funct Mater 2004)

Ga2O3 Nanowires (Adv Mater 2004)

EELS Mapping Image Ga

100 nm

TEM Image EELS Mapping Image Ti

Ga2O3-TiO2 Nano-Barcodes (Adv Mater 2005)

Room‐temperature Ferromagnetism in Well‐Aligned Zn1‐xCoxO Nanorods (APL 2004) (Appl Phys Lett 2004)

Photocatalytic Properties of the nc‐AuZnO Nanorod Composites (Appl Catal B 2006)

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

50

Determination of the Carrier Concentrations of the ZnO Nanorods using Impedance

Spectroscopy (Adv Mater 2007)

ZnO Nanowire ArrayNanoparticle Composite Dye‐Sensitized Solar Cells

(Appl Phys Lett 2007 Nanotechnology 2007 Cryst Growth amp Design 2008)

Fast‐Switching Photovoltachromic Cells with Tunable Transmittance

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

51

Our research interests are mainly focused on various applications and properties of

surfactants electroless plating techniques and catalysts for renewable energy production

Phase Behavior of Surfactants and Its Associated Applications

Application in Microanalysis and Preconcentration

Nph Flr Acp Pnt Ant Fla Pyr Baa Pel Bap

Pre

conc

entr

atio

n F

acto

r

0

50

100

150

200

25029 wt NaCl56 wt NaCl

Aqueous

Phase

Micellar solution

Bing-Hung Chen (陳炳宏教授)

Professor BS Chemical Engineering National

Taiwan University

1990

PhD Chemical Engineering Rice

University Houston Texas USA

1998

Email bkchenmailnckuedutw

Tel (06) 275 ndash 7575 Ext 62695

Office Room 93B08 Chemical Engineering Building

Liquid Crystalline L Phase (Myelins)

Monomer

PAH

Cloud‐point

Extraction

Surfactant‐rich Phase

Performance of the L3‐phase extraction on hydrophobic solutes such as polycyclic aromatic hydrocarbons (PAHs)

Cloud‐point Extraction (CPE)

L phase

W W+L L L2

Typical Aqueous Phase Sequence of Surfactant

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

52

Applications in Enhanced Drug Delivery using Emulsion Formulations

Catalysts for Renewable Energy Production

Electroless Plating Techniques

Selected Publications

(1) D Carr PR Garrett D Giles G Pierre‐Louis E Staples C A Miller B‐H Chen ldquoSolubilization of Triolein by Microemulsions Containing C12E4HexadecaneWater Equilibrium and Dynamicsrdquo Journal of Colloid and Interface Science 325(2) 508ndash515 (2008)

(2) JndashL Li BndashH Chen ldquoEffect of Nonionic Surfactants on Biodegradation of Phenanthrene by a Marine Bacteria of Neptunomonas naphthovoransrdquo J Hazardous Materials 162(1) 66ndash73 (2009)

(3) JndashL Li D Bai BndashH Chen ldquoEffects of Additives on the Cloud Points of Selected Nonionic Linear Ethoxylated Alcohol Surfactantsrdquo Colloids and Surfaces A 346 237ndash243 (2009)

(4) J‐T Lo B‐H Chen T‐M Lee J Han J‐L Li ldquoSelf‐Emulsifying OW Formulations of Paclitaxel Prepared from Mixed Nonionic Surfactantsrdquo J Pharm Sci 99(5) 2320ndash2332 (2010)

(5) CndashL Hsueh CndashH Liu BndashH Chen MndashS Lee CndashY Chen YndashW Lu F H Tsau JndashR Ku ldquoA novel design of solid‐state NaBH4 composite as a hydrogen source for 2W PEMFC applicationsrdquo Journal of Power Sources 196(7) 3530ndash3538 (2011)

Paclitaxel as the model drug Good shelf stability over 10 months containing 1000 ppm Taxol in OW emulsions was obtained using food‐grade surfactants and lipids

20 nm

Surfactant can reduce void (pit) formation on electroless Ni thin films

20 nm

Schematic of electroless plating technique

2 W

Biodiesel made from transesterification of triglycerides over acid‐modified mordenites A cellular phone recharged from a 2W PEMFC

powered by H2 produced from NaBH4 hydrolysis over synthesized light‐weight Co catalyst

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

53

Our research group is interested in water purification and wastewater treatment processes We

mainly focus on advanced chemical oxidation In Taiwan many industrial wastewater treatment

plants must add advanced treatment units to meet the effluent standards Advanced oxidation

processes (AOPs) which involve the generation of hydroxyl radical (OH) are widely being used

for treating not only industrial wastewater but also drinking water and domestic sewage AOPs

are concerned as the technology for treating non‐biodegradable organics or toxic industrial

organic compounds Advanced oxidation

processes comprise a variety of reactions

such as ozoneultraviolet ozonehydrogen

peroxide Fenton oxidation and sonolysis etc

depending on the way of producing OH

Among various advanced oxidation processes

Fentonrsquos reagent (H2O2Fe2+) has been known

to be effective The major drawback of

Fentonrsquos reaction however is the production

of substantial amount of sludge that requires

further disposal To address this problem our

research group has studied and developed a

series of modified Fenton technologies These

technologies herein termed ldquoFenton Family

Technologiesrdquo not only reduce the iron sludge

but also improve the COD removal efficiency

The outer view of FBR‐Fenton reactor

Huang Yao-Hui (黃耀輝 教授)

Professor BS National Cheng-Kung University 1983 MS National Cheng-Kung University 1986 PhD National Cheng-Kung University 1991

Email yhhuangmailnckuedutw Tel 886-6-2757575-62636 Office Room 93B13 Chemical Engineering Building

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

54

The outer view of Electro‐Fenton reactor

Theory of FBR-Fenton process

0 40 80 120 160 200 240Time (min)

20

40

60

80

100

Fe

rev

(

)

Fe2+ 20ppmSi 300gLSiG 300gL

Si pH 6Si pH 7Si pH 8SiG pH 6SiG pH 7SiG pH 8

3420 3440 3460 3480 3500 3520 3540

FeOOH

SiG2

FeOOH

SiG2

dark

Irradiation

Magnetic Field (G)

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

55

Heat integration Simulation and Optimization of Reforming-based Fuel Cell Systems

CH4

H2O Anode

Cathode

Internal reforming HEX

Catalytic Combustor

Heating Jacket

Steam

Air (O2)

CO2 H2O

Professor Wei Wu (吳煒教授)

BS Chemical Engineering Feng Chia University Taiwan

1988

MS Chemical Engineering National Taiwan University of Science and Technology

1990

PhD Chemical Engineering National Taiwan University of Science and Technology

1995

Email weiwumailnckuedutw

Tel 886-6-2757575-62689

Office Room 93A13 Chemical Engineering Building

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

56

Process Design Simulation and Control of Hybrid Renewable Energy Systems

Process Design Simulation and Optimization of Industrial Hydrogen Production Processes Subject to Energy-saving and CO2 Reduction

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

57

Investigating the Formation of Inclusion Body in Recombinant Escherichia coli with a Bioimaging System

Fig 1 Visualization of G7 protein fluorescence emitted by E coli giant protoplasts Panel (a)

corresponds to fluorescence microscopy under white light panel (b) corresponds to fluorescence microscopy under UV light both with 400‐fold magnification P1 is the protoplast without fluorescence P2 and P3 are the protoplasts emitting blue fluorescence

Chu-Yuan Cheng (鄭智元副教授)

Associate Professor

MS Chemical Engineering

TokyoUniversity Japan

1984

PhD Chemical Engineering

TokyoUniversity Japan

1989

Emailcychengmailnckuedutw

Tel06-2757575-62664

Office Room 93711 Chemical Engineering Building

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

58

Fig 2 Visualization of the inclusion bodies of G7 protein The left series correspond to fluorescence microscopy under white light the right series correspond to fluorescence microscopy under UV light both with 400‐fold magnification The inclusion bodies recovered by detergent treatment are shown in (a) and (b) The inclusion bodies recovered by osmosis shock are shown in (c) and (d) The inclusion bodies recovered by sonication shock are shown in (e) and (f)

Time after induction (h)

0 2 4 6 8 10

Fra

ctio

n o

f in

clu

sion

bod

ies

()

0

20

40

60

80

100

Fig 3 Effect of temperature on the formation of inclusion bodies in E coli giant protoplasts E coli protoplasts were incubated at pH 70 IPTG was added with a final concentration of 05

mM Symbols close circles 30C close squares 25C close triangles 20C

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

59

My research is aimed at understanding and exploiting fluid motion colloidal assembly and

dynamics of macromolecules under the influence of various forces so as to design control and

manipulate processes at small scales As phenomena typically occur within 10nm-100m there

often involve interplays among different mechanisms with more than one lengthtime scale Our

efforts first combine theoretical and experimental approaches to unravel the natures of

phenomena and then apply the knowledge to design microfluidic devices for fulfilling desired

functions The current research interests are focused on the following subjects

Directed Assembly of Colloids and Macromolecules with AC Electric Fields

When an object is placed in an AC field especially at high frequencies it often undergoes

charge polarization far from Poisson-Boltzmann equilibrium Such polarization can cause

induced dipoles aligned to the applied field and hence furnishes the advantages of guiding fluids

or suspended colloids at small scales Our efforts are not only to understand a variety of the

field-induced polarization phenomena but also to explore rich dynamic assembly behavior of

polarized colloids in the presence of AC electrokinetic flow This research further enables us to

design robust microfluidic devices for concentrating dilute DNA solutions and rapid assembly of

submicron colloids

Rapid focusing of DNA molecules with ac electric fields

Hsien-Hung Wei (魏憲鴻副教授)

Associate Professor BS Chemical Engineering National

Taiwan University Taiwan

1991

PhD Chemical Engineering 2000

Emailhhweimailnckuedutw

Tel06-2757575-62691

Office Room 93916 Chemical Engineering Building

(a) (b) (c) (d)

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

60

Dynamic assembly of colloids in an oblique electrode array subjected to ac signals

Dynamic Manipulation of Single DNA Molecules within Interfacial Confinement

We devise a new microfluidic approach capable of achieving a diversity of manipulations of

DNA with electric fields It invokes the formation of a submicron film using a closely fitting

microdroplet creating a natural confinement for rendering conformation changes of DNA

underneth the droplet We find that a confined DNA can undergo entropic trap chain

stretchingrelaxation and cyclic stick-slip motion In addition with the aid of surface

modification effects DNA molecules can be combed onto the channel surface and undergo

long-range self aggregation after the removal of the applied field Currently we are developing

theoretical models in concert with Brownian dynamics simulations to account for the observed

phenomena

Electric‐field‐driven stretch of confined DNA beneath a closely fitting microdroplet

(a) (b)

(c) (d)

E

Stationary Oil SlugDNA

E

Stationary Oil SlugDNA

10μmt=1672s 10μmt=1672s t=20s 10μmt=20s 10μm t=2219s 10μmt=2219s 10μm

10μmt=1407s 10μmt=1407s

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

61

Research Interests Polymer-Surfactant Interactions NMR and Polymers Polymer-Stabilized Quantum Dots

Polymer-Surfactant Interactions Provided that the polymer interacts with the surfactant surfactant molecules form micelle‐like aggregates at a

well‐define concentration (cac) which is always lower than the regular cmc of the surfactant

The cac of the surfactant in the presence of polymer can be detected

using pyrene fluorescence

NMR and Polymers

Sheng-Shu Hou (侯聖澍副教授)

Associate Professor BS Chemistry National Cheng Kung

University Taiwan

1991

MS ----- -------

PhD Chemical Engineering National

Cheng Kung University Taiwan

2001

Email sshoumailnckuedutw

Tel06-2757575-62641

Office Room 93B11 Chemical Engineering Building

[I1I3]Py

poly(N‐vinylformamide)

PNVF

SDS CMC (8 mM)

CAC

3 mM

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

62

The two‐dimensional NOESY NMR experiment is an effective tool to elucidate the supramolecular structure of the polymer‐surfactant complex

Polymer-Stabilized Quantum Dots The color of poly(vinylamine)‐stabilized CdS quantum dots can be tuned either by changing solution

composition or pH

20nm

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

3 () 29 () 29

10

36

2 3 5 7 9 11

0

02

04

06

08

52 () 78 () 44 () 32 34

46 () 68 () 42 36 3 32

42 () 6 () 38 32 3 3

38 () 42 36 32 3 3

44 () 32 32 3 28 3

10

30 () 29 () 29

UV irradiation

pH of cosolvent pH of cosolvent

Bright field Fluorescence

Met

hano

l vol

ume

frac

tion

20nm

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

63

MMMiiicccrrrooonnnaaannnooofffaaabbbrrriiicccaaatttiiiooonnn aaannnddd MMMiiicccrrrooonnnaaannnooofffllluuuiiidddiiicccsss LLLaaabbb (((MMMampampampMMM)))

The main research themes in my lab are micronanofabrication

micronanofluidics and BioMEMS Besides developing novel polymer

micronanofabrication techniques and understandingestablishing

the relationship between processing conditions material properties

and product quality we also utilize various lithographic methods

and soft lithography to fabricate micronanofluidic chips and

micronanostructured templates which are intended for not only the

fluidic studies but the applications in biomedical area and

nanoelectronics as well

Yi-Je Juang (莊怡哲副教授)

Associate Professor BS Chemical Engineering

National Taiwan University Taiwan

1993

MS Chemical and Biomolecular Engineering

The Ohio State University USA

1997

PhD Chemical and Biomolecular Engineering

The Ohio State University USA

2001

Emailyjjuangmailnckuedutw

Tel06-2757575-62653

Office Room 93715 Chemical Engineering Building

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

64

If your research does not generate papers it might just as well not have been done ldquoInteresting

and unpublishedrdquo is equivalent to ldquonon‐existentrdquo

‐‐by Prof George M Whitesides from Harvard University

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

65

Self-organization of magnetic objects in organic or biological templates and scaffolds offers a

powerful route to design novel materials However fabricating the densely packed and

unidirectional arrays of these objects exists considerable challenges We are developing hybrid

organic-inorganic composites with magnetic nanoparticles and nanorods aligned in polymer

matrix Our synthetic route exploits the rich phase behavior of block copolymers at nanometer

length scale for dispersing and controlling magnetic particles location and patterns By

thermodynamically induced microphase separation of block copolymers these novel composites

can form unique

morphologies We are

optimizing the processing

of polymermagnetic

nanoparticle and nanorod

composites at a molecular

level by studying the

effects of loading of the

particles with different

size and concentration

surface energy and the

surface chemical

treatment on the phase

behavior of the block

copolymers

Chieh-Tsung Lo (羅介聰助理教授)

Assistant Professor BS Chemical Engineering National Tsing

Hua University Taiwan

1998

MS Chemical Engineering National Tsing

Hua University Taiwan

2000

PhD Chemical Engineering Iowa State

University USA

2005

Emailtsunglomailnckuedutw

Tel06-2757575-62647

20 nm

Fe3O4 nanoparticles

20 30 40 50 60 70 80

0

20

40

60

80

100

(440)

(511)

(100)

(400)

Inte

nsi

ty

2

(220)

XRD pattern of Fe3O4 nanoparticles

300

PS-PVP neat block copolymer

200

PS-PVP1 Fe3O4 particles

300

PS-PVP10 Fe3O4 particles

Magnetic ParticleDiblock Copolymer Composites

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

66

Orienting the Microphase Separated Neat Block Copolymer and Its Composites in Thin Film Architecture

Synthesis and Magnetic Properties of Magnetic Nanorods

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Effect of THF solvent annealing on neat block copolymer and its compositePS-PVP PS-PVP1 Fe3O4

Q ~ 15mgcm3

Q ~ 30 mgcm3

Q ~ 20mgcm3

2 m

2 m

2 m

1 m

1 m

1 m0

0

0 0

0

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

Optical microscopy of neat block copolymer and its composite thin films

under solvent annealing

Q ~ 15 mgcm3 Q ~ 30 mgcm3

200 m

PS-PVP

200 m200 m

PS-PVP

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP1 Fe3O4

200 m200 m

PS-PVP1 Fe3O4

200 m

PS-PVP

200 m200 m

PS-PVP

Swelling coefficient

Effect of solvent annealing time on the morphology of block copolymer

thin film (Q ~ 20 mgcm3)

t = 0 h t = 05 h

t = 1 h t = 3 h

t = 6 h t = 12 h

40 nm

40 nm

40 nm

One time injection

Six times injection Eight times injection

Multiple injections of the precursor

to synthesize magnetic nanorods

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

67

Formation of supramolecular assembly by polypeptide-based copolymers and biomedical

application as carriers encapsulants scaffolds (Jan Chen Ju 2011 in preparation Yang

Huang and Jan in preparation Huang Arham and Jan Soft Matter 2011 Gaspard Silas

Shantz and Jan Supramol Chem 2010)

A simple concept to synthesize inorganic materials under benign conditions I Porous oxide and metal nanoparticlemesoporous oxide materials Synthesize porous oxide materials with different morphology using secondary structures (eg ndashhelix and ndashsheet) adopted by polypeptides polypeptide assemblies or assembled block copolypeptides as templates (Jan Chuang Chen and Teng Langmuir 2011 Jan Chen and Ho JCIS 2011 Chuang Lin Wen and Jan J Nanosci Nanotech 2011 Jan and Shantz Adv Mater 2007 Jan and Shantz Chem Commun 2005)

Jeng-Shiung Jan Assistant Professor

BS Chemical Engineering National

Taiwan University Taiwan

1994

MS Chemical Engineering National

Taiwan University Taiwan

1996

PhD Chemical Engineering Texas AampM

University Texas USA

2006

Emailjsjanmailnckuedutw

Tel06-2757575-62660

Office Room 93815 Chemical Engineering Building

Biomimetic Synthesis of Inorganic Materials

Polypeptide-Based Copolymers Self-Assembly and Biomedical Applications

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

68

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

1 m1 mm

Condition I

1 m1 mm

Condition I

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition II

200 nm200 nm200 nm

Condition III

200 nm200 nm200 nm

Condition III

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

700

600

500

400

300

200

100

0

v(cm

3g

-ST

P)

100806040200s

300

250

200

150

100

50

0

v(cm

3g

-ST

P)

100806040200s

Condition IV = 0Platelets

Condition IIV = 006 cm3gPlatelets

Condition IIIV = 017 cm3gSpheres

pp0 pp0 pp0

II Nanostuctures Synthesize silica AgBrsilica core shell hollow spheres and hollow tubes using assembled

block copolypeptides or polypeptide assemblies as templates (Jan Chuang Chen and Teng

Langmuir 2011 Jan Lee Carr and Shantz Chem Mater 2005)

20 nm20 nm 100 nm100 nm 100 nm100 nm

Particle tracking microrheology is a technique that measures the viscosity response (eg

chain size and conformation) of solutes in solution so it is suited for studies such as

polyelectrolyte-counterion interactions and foldingunfolding of proteins (Jan and

Breedveld Macromolecules 2008)

Sheet-like polypeptide assemblies templated silica

Microrheology

Block copolypeptide templated silica

Silica spheres AgBrsilica core shell Silica hollow spheres Silica hollow tubes

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

69

Our lab focuses on the development of lab-on-a-chip systems for biological and medical applications as well as alternative energy research There are three main areas that we are interested in fluid controlsample injection sample treatment and detection In the last few years we have establish several continuous flow techniques including specific delivering of reagents into cells using laminar flow flow through electroporation and microfluidic chemical cytometer In additional to the continuous flow analysis we have also established microfluidic droplet systems for controlling reaction conditions and micro-particle generations Furthermore electroporation has been applied to facilitate the transport of fluorogenic probe into the microalgae for lipid quantification ensuring that the microalgae strain was a suitable candidate for producing biodiesel Last but not least we have developed a near-infrared Raman detection system that was able to characterize cell components in vivo and in real time We are working toward a lab-on-a-chip system capable of conducting multiple analyses in series or in parallel for monitoring the cell responses

Fluid control Microfluidic droplet generation and applications

Hsiang-Yu Angie Wang (王翔郁 助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

MS Chemical Engineering National Taiwan University Taiwan

2002

PhD Chemical Engineering Purdue University USA

2007

Email hywangmailnckuedutw

Tel 886-6-2757575-62648

Office Room 93712 Chemical Engineering Building

Vcm (c)

Water

Soybean

oil

outlet

Control size and geometry of

droplets by adjusting

dimensionless numbers

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

70

Sample treatment Enhance of lipid labeling in microalgae using electroporation Detection Near-infrared Raman

(d)

Extraction of hydrophobicorganic components along the serpentine channel

Real-time monitoring

indicated that the signal

intensity was proportional to

the lipid abundance

Different microalgae contents

produce lights with various

wave lengths

Laser

microalgae

Electric field breaks down the cell membrane and

facilitates the entering of fluorescence probe into cells

Micro-electrodeMicro-electrode

Higher electric field induced

stronger fluorescence

electroporation

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

71

Our lab is centered on biomaterials which can be applied in drug controlled release and tissue engineering There are three main topics that we are interested in polymeric microneedle patches nanoparicles and electrospun nanofibers Polymeric Microneedle Patches for Transdermal Delivery of Biomacromolecules

Mei-Chin Chen (陳美瑾 助理教授)

Assistant Professor

BS Chemical and Materials Engineering National Central University Taiwan

2002

MS Chemical Engineering National Tsing Hua University Taiwan

2004

PhD Chemical Engineering National Tsing Hua University Taiwan

2008

Email kokolamailnckuedutw

Tel 886-6-2757575-62696

Office Room 93912 Chemical Engineering Building

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

72

Electrospun Superparamagnetic Yarns for Tissue Engineering Applications

Myotube Formation of C2C12 Cells

Electrospinning

Myoblasts on Superparamagnetic

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

73

Our lab is focused on the synthesis of new polymers with special functionalities and on their applications in the fields of biomedicine and optoelectronic devices The main topics we are interested in include (1) the utilization of polymeric micelles as nanocarriers for the studies of cancer treatment biosensing and bioimaging (2) stimuli-responsive polymers for controlled drug release and target delivery (3) synthesis of conjugated polymers and their application in optoelectronic devices

Applications of Nanocarriers in Biomedical Fields

Wen-Chung Wu (吳文中助理教授)

BS Chemical Engineering National Taiwan University Taiwan

2000

PhDChemical Engineering National Taiwan University Taiwan

2006

Email wcwumailnckuedutw

Tel 886-6-2757575-62643

Office Room 93C08 Chemical Engineering Building

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

74

Self‐assembly of Amphiphilic Block Copolymers and Formation of Polymeric

Micelles

Applications of Polymeric Micelles in Photodynamic Therapy

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

75

Proton exchange membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) are considered promising alternative power source for portable electronic device to stationary applications because of the high efficiency high power density low emissions low operation temperature and low noise Polymer electrolyte membranes (PEMs) are one of the key components of FCs systems However commercial applications of these membranes are limited due to their high cost high methanol crossover and difficult synthesis and processing Up to now we are making efforts in the following two topics of PEMs

In PEMFCs a low-cost PTFE-reinforced integral NafionregPTFE membrane to improve the cell performance at low humidity condition is investigating The mechanical strength chemical stability duration of the ultra-thin NafionregPTFE membrane is improved The high tensile strength makes the back diffusion distance of product water from the cathode to the anode decreases at low humidity condition and shows high power high efficiency low cost and minimize system volume with self humidification ability by tailoring the MEA structures

In DMFCs novel aromatic polymers such as sulphonated poly(ether ether ketone)s (SPEEKs) and sulphonated polyethersulphones (SPESs) that contain sulphonic acid groups along the polymer chain and format of a well-defined nano-phase separated morphology to replace commercial Nafions The results observed in these studies suggest that novel aromatic polymers with improved nano-phase separation may improve FC applications by more than approximately 20 thus the lower water diffusivity methanol permeability electro-osmotic drag coefficient and high cell performance indicated that novel aromatic polymers are promising candidate for DMFC applications

1 NafionregPTFE membrane for low humidity proton exchange membrane fuel cell

Chien-Kung Lin (林建功)

BS Chemical Engineering National

Cheng Kung University Taiwan

1989

MS Chemical Engineering National

Cheng Kung University Taiwan

1992

PhD Chemical Engineering National

Cheng Kung University Taiwan

2000

Email nickelmailnckuedutw

Tel 886-6-2757575-62681-287

Office Room 93C17 Chemical Engineering Building

Research interests

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

76

The SEM micrograph of the surface of (a) porous PTFE and (b) NafionregPTFE photograph of (c) NafionregPTFE and cell performance of (d) NafionregPTFE

(a) (b)

(c) (d)

2 Preparation of sulfonated poly(ether ether ketone) membranes for direct methanol fuel cell applications

Water flux across Nafionreg 117 and MS-SPEEK under DMFC single-cell test at 80degC

The performance curves of Nafionreg 117 and MS-SPEEKs at (a) 60degC and (b) 80degC

(a) (b)

  • cover
  • Esum-1
  • Esum-2
  • Esum-3
  • Esum-4
  • Esum-5

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