NEW DIMENSION ! NOVEL INSIGHTS

IMMUNOTHERAPY Assessing tumor immune

response with AIM chips ex vivo ORGANOTYPIC TUMOR MODELS FOR IMMUNE BLOCKADE STUDIES 1

1. Jenkins, RW., et al., Ex vivo profiling of PD-1 blockade using organotypic tumor spheroids. Cancer Discov 2018; 8(2): 196-215.

3 POWERFUL TOOL FOR DRUG DISCOVERY

MDOTS cultured in AIM chips predict the effectiveness of novel combination therapies (PD-L1 blockade + TBK1 inhibitor), as

evidenced by in vivo tests using CT26 mice

Cmpd 1 : TBK1 Inhibitor

PRESERVES IMMUNE CELLS & TUMOR MICROENVIRONMENT

RECAPITULATES THE IN VIVO IMMUNE RESPONSE

SPEEDS UP DRUG DISCOVERY & DIAGNOSTICS

Workflow to develop murine-derived /patient-derived organotypic tumor spheroids (MDOTS/PDOTS) in AIM chips

VALIDATED AGAINST ANIMAL MODELS

MDOTS cultured in AIM chips capture the in vivo responses of PD-1 sensitive MC38 and PD-1 resistant

B16F10 under PD-1 treatment

PD-1 Sensitive PD-1 Resistant

2

Tumor Biopsies

AIM 3D Cell Culture Chips

PD -1 Blockade

• Dissociation • Size Selection • Immunophenotyping

Downstream Analysis • Live Cell Imaging • Immunofluorescence • Proteomic Profiling • Genomic Profiling • Flow Cytometry

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