2 pt

transcript

REACTIVITYNAME THAT ANTIBODY COLDS GENETICS

MNSs SYSTEM

Antigens and antibodies of the Kidd blood group system can be detected in this phase of testing.

When this antibody reacts with the target antigen, the

reaction appears to be mixed-field, and the

agglutinates appear to sparkle when examined

microscopically.

Anti-Sda

This tapeworm by-product can be used to neutralize

anti-P1.

Hydatid cyst fluid

Although the Sda antigen is found in most body fluids, it will be found in the greatest

concentration here.

This IgG antibody may bind complement, then dissociate from the RBC, leaving the

complement behind. (i.e. It is a complement- dependant

antibody.)

Anti-Jka

This antibody accounts for two-thirds of all non-Rh

immune antibodies.

Anti-K

This usually cold reacting antibody will sometimes

react at 37C, causing hemolysis.

Anti-Lea or –Leb

anti-P1

The antibodies in this system are notorious for

causing delayed hemolytic transfusion reactions.

DAILY DOUBLE

This antibody rarely causes hemolytic transfusion

reactions because it can be neutralized by antigens found

in the plasma.

Parasitic infections, early abortions, and PCH have all

been associated with antibodies in this blood group.

Antibodies in these blood group systems generally react

at room temperature and below.

(LIMP)

This system’s antigens are not true red blood cell antigens, but are absorbed from the

plasma.

This antigen is found almost exclusively on red blood cells

from cord blood.

When antigens and antibodies in this system react, the agglutinates are

said to be fragile, and appear to look like clusters

of grapes.

This autoantibody reacts with all antibody screen and panel cells, and is commonly found

in the serum of Group A1 individuals.

Anti-H

(or anti-IH)

This is the most common form of inheritance for blood group antigens.

Codominant

Inheritance of this gene results in the absence of

Kidd antigens on the RBCs.

In(Jk)

[or Jk if inherited homozygously]

This Duffy phenotype is found in 68% of the black

population, but is NOT found in the white population.

Fy (a-b-)

The genes that control expression of this blood

group system are located on chromosome 1.

If a patient has homozygous inheritance of

Le, se, H and O genes, these antigens will be present in his saliva.

Lea only

Anti-M will sometimes react stronger with an RBC that has

homozygous antigen expression rather than a cell with

heterozygous antigen expression.

This is the term that describes that characteristic.

Dosage

Because MN antigens are well developed at birth, in

the past they have been useful in determining this.

Paternity

Patients undergoing renal dialysis may develop this

antibody.

Anti-N

Typing a patient’s RBCs for this antigen may not be possible. By proving the RBCs are S-s-, one

can establish the probability they are also negative for this

antigen.

This antibody has examples that react best at

a pH of 6.5.

Anti-M

2 pt

Documents