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7/23/2019 Alza - Final
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Alza PharmaceuticalsAlza PharmaceuticalsNovember 06, 2003November 06, 2003
Nina PatelNina Patel
Jesus Lopez Jesus Lopez Truc Le Truc Le
Brigitte ComrieBrigitte Comrie
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Mission StatementMission Statement
As ne compoun!s emerge "romAs ne compoun!s emerge "rombiotec#nolog$ an! genetic researc#,biotec#nolog$ an! genetic researc#,
AL%A tec#nologies continue toAL%A tec#nologies continue toevolve, provi!ing uni&ue !eliver$evolve, provi!ing uni&ue !eliver$plat"orms t#at e'ten! t#e potential o"plat"orms t#at e'ten! t#e potential o"important ne t#erapies( )ear a"terimportant ne t#erapies( )ear a"ter
$ear, e !eliver results t#at bene*t$ear, e !eliver results t#at bene*t#ealt#care an! e'pan! mar+et#ealt#care an! e'pan! mar+etopportunities "or our p#armaceuticalopportunities "or our p#armaceuticalpartners(partners(
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Alza HistoryAlza History
oun!e! in -.6/oun!e! in -.6/
b$ r( Ale1an!rob$ r( Ale1an!ro
%aaroni%aaroni
ea!&uartersea!&uarters
locate! inlocate! in
4ountain 5ie,4ountain 5ie,
Cali"orniaCali"ornia
t#er "acilitiest#er "acilities
t#roug#out t#e 7(8(t#roug#out t#e 7(8(
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Alza History cont.Alza History cont.
-.93 : irst-.93 : irst
tec#nolog$ astec#nolog$ as
!evelope!; <8!evelope!; <8 -.96 : AL%A-.96 : AL%A
intro!uce! AL%=Tintro!uce! AL%=T
> smotic> smotic
PumpsPumps
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Alza History cont.Alza History cont.
-... : AL%A-... : AL%A
merges it#merges it#
8e&uus8e&uusP#armaceuticalsP#armaceuticals
200- : AL%A200- : AL%A
becomes part o"becomes part o"
Jo#nson ? Jo#nson ?
Jo#nsom "amil$ o" Jo#nsom "amil$ o"
companiescompanies
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Alza TechnologyAlza Technology
<8 ral eliver$<8 ral eliver$ @Trans Trans!ermal@Trans Trans!ermal
8T=ALT Liposomal8T=ALT Liposomal 7<8 mplant7<8 mplant =@Trans Trans!ermal=@Trans Trans!ermal
4acrou' Trans!ermal4acrou' Trans!ermal AL%A4=< epotAL%A4=< epot t#ert#er
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OROS Oral DeliveryOROS Oral Delivery
-- Commercial-- CommercialPro!uctsPro!ucts
SudafedSudafed @ 2 #our@ 2 #ourrelie" relie"
ConcertaConcerta :re!uce:re!uceA s$mptomsA s$mptoms
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OROS Oral DeliveryOROS Oral Delivery
nvestments;nvestments;
: mprove poor a&ueous solubilit$mprove poor a&ueous solubilit$
: mprove poor absorptionmprove poor absorption: <e!uce large molecular size o" pro!ucts<e!uce large molecular size o" pro!ucts
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OROS Oral DeliveryOROS Oral Delivery
Control !rug !eliver$ "or up to 2Control !rug !eliver$ "or up to 2
#ours#ours
Provi!e eDcient !rug absorptionProvi!e eDcient !rug absorption
an! en#ance! bioavailabilit$an! en#ance! bioavailabilit$
=liminate !rug absorption=liminate !rug absorptionvariabilit$ cause! b$ gastric pvariabilit$ cause! b$ gastric p
an! motilit$an! motilit$
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D-Trans TransdermalD-Trans Transdermal
9 commercial pro!ucts9 commercial pro!ucts
NicodermNicoderm ::Nicotine Patc#Nicotine Patc#
Transderm ScopTransderm Scop ::4otion 8ic+ness4otion 8ic+ness
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D-Trans TransdermalD-Trans Transdermal
nvestments;nvestments;
: ncrease !rug permeation t#roug# s+inncrease !rug permeation t#roug# s+in
: <e!uce irritation potential<e!uce irritation potential
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D-Trans TransdermalD-Trans Transdermal
rug !eliver$ - !a$rug !eliver$ - !a$to - ee+ it# oneto - ee+ it# oneapplicationapplication
Convenient, painless,Convenient, painless,cost@eectivecost@eective
=n#ance t#erapeutic=n#ance t#erapeuticeDcac$ #ileeDcac$ #ile!ecreasing si!e!ecreasing si!eeects becauseeects becauseavoi!s eects on t#eavoi!s eects on t#egastrointestinal tractgastrointestinal tract
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STEATH i!osomalSTEATH i!osomal
o'ilo'il
: ntravenous anticancer !rugntravenous anticancer !rug
: Treats re"ractor$ ovarian cancer an! Treats re"ractor$ ovarian cancer an!A8 relate! EaposiFsA8 relate! EaposiFs
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STEATH i!osomalSTEATH i!osomal
esigne! to re!uce to'icit$ o"esigne! to re!uce to'icit$ o"
intravenous !rugs it# siteintravenous !rugs it# site
speci*c targetingspeci*c targeting 4aterials4aterials
: Liposomes; li&ui! microsp#eresLiposomes; li&ui! microsp#eres
: Pol$et#$lene gl$col coatingPol$et#$lene gl$col coating
Liposomal 4icrosp#ere
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STEATH i!osomalSTEATH i!osomal
Not !etecte! b$ t#eNot !etecte! b$ t#eimmune s$stemimmune s$stem
Targets lea+$ Targets lea+$vasculature o"vasculature o"!isease! tissue "or!isease! tissue "orincrease !rugincrease !rug
concentrationconcentration Ligan@recptor bin!ingLigan@recptor bin!ing
s$stem improvess$stem improvesupta+e o" !rugupta+e o" !rug
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A"A TechnologiesA"A Technologies
D#ROS $m!lant%D#ROS $m!lant% Viadur®Viadur® : Treats Prostate Cancer Treats Prostate Cancer
E-Trans Transdermal%E-Trans Transdermal% – Capability of an IV pumps without the needleCapability of an IV pumps without the needle
Macro&u' TransdermalMacro&u' Transdermal;; : T Thin titanium screen with precisionhin titanium screen with precision
microprojectionsmicroprojections A"AMER De!ot%A"AMER De!ot%
– extended period drug deliveryextended period drug delivery
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(ommercial Products(ommercial Products
Actisite) *tetracycline+Actisite) *tetracycline+
: perio!ontal *berperio!ontal *ber
: <e!uces poc+et !ept# an! blee!ing on<e!uces poc+et !ept# an! blee!ing onprobing in patients it# a!ult perio!ontitisprobing in patients it# a!ult perio!ontitis
A"ET)A"ET)
: osmotic pumps "or laborator$ researc#(osmotic pumps "or laborator$ researc#(
,a'ter) $nusor,a'ter) $nusor
: controlle! intravenous !eliver$ o"controlle! intravenous !eliver$ o"
anticoagulants, antibiotics an!anticoagulants, antibiotics an!
c#emot#erapeutic agentsc#emot#erapeutic agents
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(ommercial Products(ommercial Products
$OME( SR) ,olus *ivermectin+$OME( SR) ,olus *ivermectin+ : control o" ma1or internal an! e'ternalcontrol o" ma1or internal an! e'ternal
parasites in cattleparasites in cattle
Ocusert) *!ilocar!ine+Ocusert) *!ilocar!ine+ : ocular t#erapeutic s$stemsocular t#erapeutic s$stems
: Controls elevate! intraocular pressureControls elevate! intraocular pressureglaucoma patientsglaucoma patients
Progestasert) *!rogesterone+Progestasert) *!rogesterone+: intrauterine contraceptive s$stem "orintrauterine contraceptive s$stem "or
localize! !eliver$ o" progesterone "or one $earlocalize! !eliver$ o" progesterone "or one $ear
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/or0ing or Alza/or0ing or Alza
4ember o" Jo#nson an! Jo#nson4ember o" Jo#nson an! Jo#nson ver 2000 emplo$ees at t#reever 2000 emplo$ees at t#ree
sites; 4ountain 5ie, CAG 5acaville,sites; 4ountain 5ie, CAG 5acaville,CAG Cas#el, relan!CAG Cas#el, relan!
HH8mall compan$ environment, big8mall compan$ environment, big
compan$ impactIcompan$ impactI ierent opportunities interns#ips,ierent opportunities interns#ips,
gra!uate positions, etc(Kgra!uate positions, etc(K
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/or0 Environment/or0 Environment
HH8mall compan$ environment, Big8mall compan$ environment, Big
compan$ impactIcompan$ impactI
Team oriente! emplo$ees Team oriente! emplo$ees e!icate! to improving t#e livese!icate! to improving t#e lives
o" people orl!i!eo" people orl!i!e
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Alza aluesAlza alues
Enole!ge, s+ills, an! t#eEnole!ge, s+ills, an! t#eabilities o" t#eir emplo$eesabilities o" t#eir emplo$ees
e!ication to creating an!e!ication to creating an!!eveloping #ig# &ualit$ pro!ucts!eveloping #ig# &ualit$ pro!ucts
Provi!ing several !ierentProvi!ing several !ierent
opportunities "or emplo$ees toopportunities "or emplo$ees toe'c#ange i!eas an! socialize it#e'c#ange i!eas an! socialize it#colleaguescolleagues
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,ene1ts,ene1ts
2ohnson and 2ohnson 2ohnson and 2ohnsonPer0sPer0s
4e!ical nsurance4e!ical nsurance ental nsuranceental nsurance
Li"e nsurance Term an!Li"e nsurance Term an!7niversalK7niversalK Acci!ent nsuranceAcci!ent nsurance 8#ort Term isabilit$8#ort Term isabilit$
coveragecoverage Long Term isabilit$Long Term isabilit$
coveragecoverage Long Term CareLong Term Care Pension PlanPension Plan 8avings Plan 0-+K8avings Plan 0-+K A!option AssistanceA!option Assistance
Additional Alza 3ene1tsAdditional Alza 3ene1ts =mplo$ee 8toc+ Purc#ase=mplo$ee 8toc+ Purc#ase
PlanPlan Tuition <eimbursement Tuition <eimbursement
5acation5acation Compan$ oli!a$sCompan$ oli!a$s Compan$ 8tores=@8toresCompan$ 8tores=@8tores ='ercise Programs='ercise Programs a$care iscountsa$care iscounts 8ervice Aar! Program8ervice Aar! Program Li"eor+s ProgramLi"eor+s Program C#aritable ContributionsC#aritable Contributions 4atc#ing Mi"t Program4atc#ing Mi"t Program
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4uestions54uestions5