ControlHDL

Nitrated ApoA-I

8.0

4.0

p<0.005

Cho

lest

erol

Effl

ux (%

con

trol

)

ClorinatedApoA-I

Myeloperoxidase Catalyzed Nitration and Chlorination Of ApoA-I Decreases ABCA1

Mediated Efflux

p<0.01

Nicholls SJ. et al. Trends in Cardiovascular Medicine 2005;15:212-219

Santos RD, et al. J Lipid Res 2008;49:349-357.

Homozygous Familial ApoA-I Deficiency

ABCA1 Transporter Deficiency – Tangier Disease