Post on 26-Mar-2015
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BUSINESS OPPORTUNITIES IN BIOTECHNOLOGY IN INDIA
P. K. Ghosh, Ph DManaging Director
KEE GAD Biogen Pvt. Ltd., New Delhi
(Former Adviser DBT, GOI)
pkghosh@keepharma.com
March 06, 2009
INDIAN EFFORTS TO SUSTAIN EMINENCE IN BIOTECHNOLOGY: MOSTLY A GOVERNMENT EFFORT
Government Departments DBT DST DSIR DRDO DOE & Others
Autonomous Institutions CSIR ICAR ICMR UGC/AICTE Institutions Other Institutions
P. K. Ghosh
INDIAN BIOTECH IN GLOBAL CONTEXT
Publications and Patents filings on the rise
Leadership in innovation is yet narrow
R&D Institutes & Universities low in Global ranking
Research in Industry not significant yet
Innovation and Application not strongly linked
Academia not ready to take risk for a venture
P. K. Ghosh
HEALTH & WEALTH: INDEX FOR DEVELOPMENT
A Country is highly developed if it has……
Break through remedies for major diseases like:
Cardiovascular diseases
Cancer
Viral Diseases
Killer Bacterial Diseases
Abundant availability of Clothing, Food & Drinking water
Sound Knowledge and Practice of good Hygiene
High Quality Jobs
Technologically Advanced Industries
In all the above areas Biotech can make a contribution….
P. K. Ghosh
SKILLS THAT REVOLUTIONIZED BIOTECHNOLOGY
rDNAs & MAbs
Microscopy and Imaging
Proteins & Nucleotide sequencing
PCR Technology
LC-MS & MALDI-TOP
Flow-cytometry & Cell Sorting Techniques
Chromatography & Electrophoresis
Protein & DNA Chips & Microarrays
Bio-Informatics
P. K. Ghosh
TOP CONCERNS OF INDIAN BIOTECH INDUSTRY
Scarce availability of leaders for company specific needs
Inadequate availability of skilled work force
Limited resources for research- Internal & External
Maintenance of Confidentiality
Issues of Intellectual Property
Bridging issues between R&D Institutions & Industry
Demanding statutory requirements
Biased concerns about products by opinion makers
Limited linkage between Industry need & Public research
P. K. Ghosh
BENEFITS OF TECHNOLOGY TRANSFER BY R&D INSTITUTES
To push discovery into the market
To attract Funding & Industrial Partnership
Budding skills can be placed into rewarding projects
To earn rewards through income & fame
Obliged to be transparent by disclosers – Projects, Employees, Sponsors etc.
Economic development and Societal uplift
P. K. Ghosh
BIOTECH APPLICATIONS
Health Care Agriculture
Environment Industry
GM- Planting Mats. & Hybrids
Micro-propagation
Bio-fertilizers & Bio-pesticides
Animal Improvement
r-DNA Products, Vaccines & Diagnostics Monoclonal Antibodies
Stem CellsTissue Specific delivery methods
Enzymes Fermentation based Products & Food
Biotech Instruments & Equipment Bio-energy & Bio-fuel
BioinformaticsBio-mining
Soil & Water remediationBio-safety & GMOs
P. K. Ghosh
BUSINESS OPPORTUNITIES: HEALTH CARE
rDNA Products & MAbs Cloning, Cell multiplication, Product separation & Formulations
Choice of technologies
Stem Cell Manipulation Isolation, purification & multiplication of tissue specific stem cells
Expertise in Cell re-programming to pluripotency
Over expression of certain Genes for Cell re-programming
Retro & Non-retroviral means of over expression of target genes
Tissue Specific Delivery Technologies Choice of Bio-degradable polymers & modification methods
Choice of technologies for production of precise Nano-particles
P. K. Ghosh
BUSINESS OPPORTUNITIES: AGRICULTURE
GM- Seeds: Varieties & Hybrids Choice of right materials
Cloning, Micro-propagation & Field Testing
Generation of Food & Environmental Safety Information
Extensive Public-Private Collaboration involving Opining Makers
Animal Improvement Land & Aquatic Animals Identification for Multiplication
Choice of Exotic Animal germplasm & Multiplication methods
Feed & Fodder Production technologies
P. K. Ghosh
BUSINESS OPPORTUNITIES: INDUSTRY & ENVIRONMENT
Industry r-DNA methods of producing Enzymes
Fermented Food & Beverages
Software Development for use in Biotech operations
Biotech Instruments through Electronics, Software & New Materials
Biomass Multiplication & Bio-fuel
Environment Biosafety Information generation for commercial use of GMOs
Degraded/ Polluted Soil & Water Remediation methods
P. K. Ghosh
BIOTECH PRODUCT DEVELOPMENT TREND
Drugs & Pharmaceuticals for Human
Isolating/Developing & Multiplying Totipotent Stem Cells
Genetically Modified Seeds for Agriculture
Instruments for Biotechnology
Bioinformatics
P. K. Ghosh
Biotech drugs innovation process
New Idea/ Research
Proof of Concept
Pilot Development
Production Unit setting up &
implementation into valuable form
Marketing feedback analysis
Animal Studies
Phase I, II, III Studies
Marketing Strategy
Time (Years)
Act
ors
05 10 15
R&D Institutes
Technology Development & Transfer
Strong Industry Motivation for Success
Regulatory Approval
Mon
ey S
pent
WHAT ARE THE SURVIVAL LANES?
To Intensify Basic Research
To Develop Novel Methods for Bio-generics
Mass Production of Multivalent Vaccines
Mass Production of Cheap Diagnostics
Novel Drug Delivery & Nanotechnology
GM Varieties from Public Institutions
Micro-propagation of elites
Industrial Enzymes by r-DNA technology
Mass Composting of wastes
Enzyme Enriched Food & Neutraceuticals
Bio-energy & Bio-fuels
P. K. Ghosh
THANK YOU
Turbulence ahead…
P. K. Ghosh