Department of Marine Life Science /Marine Bio Research & Education Center  College of Natural Sciences

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Van-Tinh NguyenMarine Bioactive Substances Lab.Department of Marine Life Science

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Cancer

The Death ?11/7/2012

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Questions we will try to answer11/7/2012

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How do you get cancer?

How are cancerous cells

different than normal cells?

What is the cancer?11/7/2012

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scary

Most frequent cancer in the world

http://www.partsofthebody.net/cancer/

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http://www.healthcareatoz.com/

Causes of Cancer

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Stages of tumor development

Tumor clonality

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Development of colon carcinomas11/7/2012

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Properties of cancer cells

Density-dependent inhibition

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Autocrine growth stimulation11/7/2012

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Growth control in a normal cell

Signaling cell

Growth factor

Growth factor binds to receptor

Receptor sets off a signal cascade to

nucleus

Target cell entersS-phase and divides,eventually repairing

woundTarget cell

Nucleus

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1. Cell might produce its own growth factor

Several ways to get faulty growth control in a cancer cell

2. Mutant receptor might turn on even withoutbinding growth factor

3. Signal cascade might occur even without triggerfrom receptor

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Tumor viruses

DNA —> RNA —> protein

ss = single strand; ds = double strand.(+) RNA is the one which can function as mRNA for the synthesis of proteins.  (-) RNA cannot function as mRNA. RT = Reverse transcriptase

http://www.nlv.ch/Virologytutorials/Classification.htm

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HBV Replication cycle

Crowther R. The Leeuwenhoek lecture 2006.Microscopy goes cold: frozen viruses reveal their structural secrets. Trans. R. Soc. B 2008;363:2441-2451http://www.ibibiobase.com/projects/hepatitis/hepatitis-aB.htm

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SV40 and Polyomavirus11/7/2012

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Adenovirus11/7/2012

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The life cycle of retrovirus11/7/2012

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Proto-oncogenes11/7/2012

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Retroviral Oncogenes11/7/2012

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Oncogenes in human cancer

Point mutations in ras oncogenes

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Translocation of c-myc and abl

Translocation of c-myc

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Functions of oncogene products

Oncogenes and the ERK signaling pathway

The AP-1 transcription factor

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Functions of oncogene products

Mechanism of Tel/PDGFR oncogene activation

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Functions of oncogene products

Action of the PML/RARα oncogene

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Oncogenes and cell survival

Tumor suppressor genes

Suppression of tumorigenicity by cell fusion

Inheritance of retinoblastoma

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Suppresion of cell survival by PTEN11/7/2012

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Action of p53 in apoptosisInhibition of cell cycle progression by Rb and p16

Molecular approaches to cancer treatment

Prevention and early detection Molecular diagnosis Treatment

http://www.wwu.edu

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Thank you for listening

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