Esophageal Strictures

William Stanford – Leader & BSACDaniel Frost – BWIG

Thomas Fleming – Communicator

Client:Dr. Mark Reichelderfer, MD

Advisor:Professor John Webster

Presentation Outline

•Problem Statement

•Background Information

•Current Methods

•Design Constraints

•Possible Designs

•Future Work

Background Information•Esophageal Stricture

•Stomach acid reflux into esophagus forms stricture•Also from cancer, lung problems, and genetics•Causes heartburn

•Treatment•Surgery and dilation

•Surgery is complicated and risky•Dilation is more safe

•Inflatable balloon inside the esophagus

Background Information

•Stricture Size and Compliance

•Compliance = Volume/Pressure

•Little work has been done involving compliance

•Compliance gives information about scar tissue

•Can lead to better treatment options

•Potential correlation between stricture types

Problem Statement

Device should:

•Measure pressure in balloon

•Measure change in volume of syringe

•Graph volume/pressure curve in real time

•Be aesthetically pleasing for hospital setting

•Eventually be commercially available

Design Constraints

•Work with current dilation procedure

•Provide real time data

•Provide warning of esophageal perforation

•Software that runs on hospital computers

•Compliance accurate to three significant figures

•Compact enough for hospital setting

•Safety

Current Prototype•Syringe is filled with saline

•Pressure measured with pressure transducer

•Volume measured with linear potentiometer

•Outputs are connected to an amplifier circuit

•Circuit connects to computer

Design 1: LabViewAdvantages:

•Real time graphing•Reads two inputs•Automatically converts units•Simple inputs•Image oriented programming

Disadvantages:•Complicated•Time consuming to learn•Relatively expensive

Design 2: BioBench

Advantages:•No programming required•Has a playback mode•Multiple inputs•Less expensive

Disadvantages:•No real time graphing•No automatic unit conversion•Data has to be exported in Microsoft Excel

Design 3: PascoAdvantages:•Real time graphing•Data can be entered into equations•Easy to use•Two inputs•Least expensive

Disadvantages:•No support for saline pressure sensor

Design MatrixWeight (out of 100)

LabView BioBench Pasco

Graphing Capability

70 70 10 60

Ease of Use 5 2 3 4

Inputs 10 9 9 0

Unit Conversion

10 8 1 6

Cost 5 1 2 5

Total 100 90 25 75

Future Work

•Write software program for graphing

•Develop amplification circuit

•Testing

•Aesthetic finalization

•Gain IRB approval

•Human testing

References

•http://sine.ni.com/nips/cds/view/p/lang/en/nid/1454

•http://en.wikipedia.org/wiki/Image:Labview-logo.png

•http://www.pasco.com

•Hale, A. et. al. (2002). Barostat to Measure Esophageal Strictures.

•Kirking, H. et. al. (2002). Barostat to Measure Esophageal Strictures.

•Seashore, K. et. al. (2006). Device for Dilating Esophageal Strictures.