p p p p e p p f f f f f f p f f r p p f p f p f

p e p p p p f f f f f p p p p cf cf p p f f f p f

p p p f p f p e p f f w r f r cf p f p f p f p e

p p p p p e p p p cl cl w w r e p p p f f p f e r

p p p p e f p p w w f p f r e p p p f f f f f r

p p p p e p p p p p p p f p p f f p p f f f f f

p p p p p p p p p p p p f p p p f p p p f p f p

p p p p p p p p p p p p p p p f f p f p e p f f

p p p p p p p p p p p p p p p f p p p p p p p p

p p p p p f p p p p p p p p p p f p p p f p f p

p f f p p p p p p p p p p p p p p p p p e e f f

p p e p p f p p p p p f p p p p p p p p f p p p

p p f p f f f p p p p p p p p p e e p f p p p p

p p p p p p f p p p p p p p e p f e r f p p p p

p p p p p p p p e p p p p p e f p p r p p p p p

p e p p p p p p w p p f p p e e f p p p p p p p

111111

FibrinCholesterol Mix Cell-Fibrin

LeukocytesErytrocytesPlatelet

Exemple = 1 Image

LIMITATIONS

1- Analysis of the main aspirated piece of the thrombus only

2- Potential distortion during thrombo-aspiration

3- Younger thrombus could be superimposed with an older one

4- No increase of the % of erythrocytes with time (“Red Thrombi”)

A crucial role for early anti-thrombotic treatment

Platelet and thrombin inhibition with fast acting drugs especially in early presenters <3 hours

Conclusion

First human confirmation of the generally accepted pathogenesis of clot formation in vivo in patients presenting an acute coronary thrombosis (STEMI).

(n=911)

A potential prognostic marker that is linked to short and long-term mortality in previous study (Kramer et al. Circulation 2009)

Did not impact reperfusion in this limited size mechanistic study

Highlight the crucial role of fast-acting platelet and thrombin inhibitor in STEMI presenters