Post on 26-May-2015
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Immune system
Histophysiology
Innate Immunity
The innate immunity system is what we are born with
It is nonspecific
All antigens are attacked equally.
It is genetically based
We pass it on to our offspring.
Surface Barriers or Mucosal Immunity1.The first the most important barrier is the skin and mucosa. 2. Secretion on surface of skin and mucosa3. Epithelial barrier4. Macrophages, mast cells5. Blood cells: platelets, Nph, Eo, NK
Cells mediating immunity
Antigen presenting cells
Antigen processing and presentation
Diversity of dendritic cells
Organs of immune system
Central organs:
-Red bone marrow
- Thymus
Peripheral
-Spleen
- Lymph nodes
- MALT
Red bone marrow
Myeloid tissue-Hematopoietic cells-Microenvironment
Key morphological features
1. Sinusoidal capillaries
2. Megakaryocytes
3. Adipocytes
4. Many immature and
maturing cells
Cells maturation and kinetics in RBM
Thymus
1. Type of structure is parenchymal lobulated
2. Parenchyme is lymphoid tissue.
3. Each lobule consists of cortex and medulla.
4. In medulla there are Hassal`s bodies
Selection of lymphocytes in thymus
Types of T-lymphocytes
Regulatory T cells: friend or foe in immunity to infection?
Spleen
1. Type of structure is parenchymal
2. Stroma is composed by capsule and trabecules (DCT +SM + ElF)
3. Parenchyme includes red and white pulp.
3. White pulp is lymphoid tissue, forms LSh and LF.
4. Red pulp includes sinusoids and cords.
Spleen
Spleen
Lymph nodes
Lymph node
1. Type of structure is parenchymal
2. Stroma is composed by capsule and trabecules (DCT)
3. Parenchyme includes cortex and medulla.
4. Cortex includes LFs and paracortical zone.
5. Medulla includes sinuses and medullary cords.
Lymph node
Funny humoral immunity