Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen

Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

by Laura Bonifaz, David Bonnyay, Karsten Mahnke, Miguel Rivera, Michel C. Nussenzweig, and Ralph M. Steinman

JEMVolume 196(12):1627-1638

December 16, 2002

© 2002 Rockefeller University Press

Conjugation and delivery of OVA via monoclonal antibodies.

Bonifaz L et al. JEM 2002;196:1627-1638

© 2002 Rockefeller University Press

Targeting of αDEC-205:OVA to CD11c+ lymph node DCs in vitro.

Bonifaz L et al. JEM 2002;196:1627-1638

© 2002 Rockefeller University Press

Targeting of αDEC-205:OVA to lymph node CD11c+ DCs in vivo.

Bonifaz L et al. JEM 2002;196:1627-1638

© 2002 Rockefeller University Press

Maturation of DCs in vivo by agonistic αCD40 but not by αDEC-205:OVA.

Bonifaz L et al. JEM 2002;196:1627-1638

© 2002 Rockefeller University Press

Contrasting responses of OT-I T cells to αDEC-205:OVA in the presence or absence of αCD40-induced DC maturation.

Bonifaz L et al. JEM 2002;196:1627-1638

© 2002 Rockefeller University Press

Deletion of OT-I T cells in response to αDEC-205:OVA in steady state.

Bonifaz L et al. JEM 2002;196:1627-1638

© 2002 Rockefeller University Press

αDEC-205:OVA induces peripheral tolerance to OVA in the steady state.

Bonifaz L et al. JEM 2002;196:1627-1638

© 2002 Rockefeller University Press