Kim Solez 204 years of banff spirit November 10 2017

transcript

Kim Solez World Exponential Timeline

From Homer Smith 1895 to Aug. 7, 2099

1934 Leonard Cohen

1941 Paul Simon 1945 Rod Stewart 1991 Ed Sheeran

1994 Mallory Chipman

1901 Louis Armstrong

1920 Robert Heptinstall

1943 Janis Joplin

1961 Peter Diamandis

Think Different

It is different to mix science, music, and poetry together as we have done in this presentation!

Think Different – Kim Solez sharing cyberNephrology 5B3.09 WCM HSC with

Students & Fellows

Annette Shaff / Shutterstock.com

204 Years of the Spirit of Banff 1895-2099 122 Back 82 Forward

Homer Smith, born 1895, turned Kim on to the kidney in med school 3rd yr.

Homer Smith born 1895 Turned me on to kidney in med school 3rd year .

Louis Armstrong, born 1901, Turned Kim on to the trumpet and jazz.

Robert Heptinstall, born 1920, was Kim Solez’smentor in renal pathology

Solez, Morel-Maroger, and SraerMedicine 58:362-376, 1979. Morphology of "acute tubular necrosis" in man: Analysis of 57 renal biopsies and comparison with the glycerol model. My most cited paper before coming to Edmonton as Chair of Pathology.

Solez, Morel-Maroger, and SraerMedicine 58:362-376, 1979

1. Of the 12 lesions assessed in the 57 “ATN” biopsies 10 persisted after functional recovery. Only 2 lesions correlated with function, were present when renal failure was present and absent after recovery: 1)thinning of PAS positive brush border, & 2) shedding of individual tubular epithelial cells leaving bare basement membrane.

2. Lesions which persisted after recovery of function included tubular dilation, regeneration, mitoses, casts, interstitial edema, inflammation, nucleated cells in vasa recta, dilation of Bowman’s capsule, tubularization of Bowman’s capsule epithelium, & juxtaglomerular apparatus hyperplasia. The latter two were more prominent in recovery biopsies.

3. Lumping all acute tubular injury lesions together guarantees that histology assessment will appear to be inferior to molecular assessment, since the majority of ATI lesions persist after functional recovery. Only studies which separately assess the two lesions which correlate functionally are valid. i.e. 1)thinning or absence of PAS positive brush border, & 2) shedding of individual tubular epithelial cells .

Paper still referred to in recent reviews, findings uncontested.

Basile et al., 2012

Cannot say molecules change faster than morphology until you look at these two lesions, BB loss and cell exfoliation!

Basile et al., 2012

Heptinstall called the 1979 paper ”the best that can be done with a difficult subject!”

Later work on Transplant Acute Tubular Injury Was an Important Antecedent to Banff Studies

1993 KI paper on Transplant ATI.

New insights into transplant ATN, Solez et al. 1993Brush border loss not a feature of transplant ATN.

Leonard Cohen, born 1934, turned Kim on to poetry and his style of music

Nine months after meeting Kim Solez over 3 day weekend in 2005 Leonard wrote song inspired by

their discussion of Banff borderline changes.

Ten years later Leonard removed all but one of the borderlines and the song became the popular

“Treaty” on the 2016 You Want It Darker album.“I wish there was a treaty we could sign

I do not care who takes this bloody hill …

I wish there was a treaty we could sign

It’s over now the water and the wine

We were broken then but now we’re borderline

I wish there was a treaty

Between your love and mine”

The notebook pages showing this ten year song transition were the only such pages reproduced in the program for the “Tower of Song” Tribute Concert in Montreal at the Bell Centre November 6th, 2017.

Paul Simon, born 1941, has inspired Kim with his lyrics for a long time

Janis Joplin, born 1943, inspired Kim and was a friend of Leonard Cohen

Rod Stewart, born 1945, inspired Kim Solez and Lorraine Racusen

Kim Solez, born 1946, already plotting things at age 3 seen here with father.

His first memory of event impacting outside world, age 7: Hearing Queen Elizabeth Coronation on

Radio in 1953

The Origin of Kim’s Diversity Beliefs at Age 7, Yasmini.

Which Led to This 2008 Essay

Ray Kurzweil, born 1948, co-founder of Singularity University, is Kim Solez’s most important technology

influence.

Peter Diamandis, co-founder of Singularity University born in 1961, is an important technology

influence.

Ed Sheeran, born in 1991, is an important musical influence on Kim.

Banff Transplant Pathology Classification Began at The

TransCanada Pipeline Pavilion at the Banff Centre for Conferences in 1991

Banff meeting slide box mentioned in first Banff abstract in 1991 is in itself

also an important player in story .

Ironically the last Banff classification workshop in which these slides were

used was in 2004 in Aleppo, Syria.

Mallory Chipman, born 1994, is an important musical collaborator in

technology&Leonard Cohen events!

Kim&Mallory initiated Technology&AllThat Jazz Project to broaden the reach

of important ideas in science.

We had our own “Stanley meets Livingstone” moment when Tori Sheldon and Mallory met in June 2017. They will be working together at the TERMIS International Congress in Kyoto in September 2018.

So where will it end? The farthest future date in song Kim Solez can

conceptualize is Aug. 7, 2099

We have ended the timeline with Aug. 7, 2099, and will create an event page but then again there is also this song!

So maybe we have to push our imaginations to 5555. Kim Solez can

imagine that Banff will still be remembered in 2525, but not in 5555!

Kim Solez, MD

Pennan, Scotland near Banff is where classic 1983 movie “Local Hero” was shot

Kim Solez with meeting coordinator Michele Hales in 2002 in Pennan.

2003 image from Aberdeen Banff meeting. Lorraine Racusen is in the center and Michele Hales is beside her. Phil Halloran is behind Michele. Jake Demetris is at far left.

Tori Sheldon and Akshatha Raghuveer. In 2007 we lost our funding from the NKF and student staffing

began.

Many students have contributed extensively to Banff meetings.

Video has become an important part of meetings, Patricia Bacus, Banff 2017

Nikki Olson was important part of early video efforts and creation of Tech&Future of Medicine

course

Laurie Bennett also provided early videography assistance to Kim Solez

In recent years Tatiana Zagorac has become main videography advisor to Kim Solez

Another important local hero is the local Banff meeting director, like Daniel Seron in

Banff 2017. The subject of another ppt!

Kim Solez, MD

In 1991 Kim Solez and Lorraine Racusen Directed the First Banff Meeting Which Created the Banff Classification of Transplant Pathology and Banff Consensus Process

Classification established, lesion scoring, diagnostic categories, physician-led consensus

BANFF CLASSIFICATION STANDARD FOR TRANSPLANT BIOPSY INTERPRETATION

Began in kidney (Solez et al. 1993), and was then extended to liver, pancreas, composite tissue grafts etc. Meetings also consider heart, lung, small bowel.

Uses semiquantitative lesion scoring 0-3+ and diagnostic categories. A pathologic classification of all pathologic changes, not just rejection.

1993 Meeting was joint with Canadian Association of Pathologists – Future Consortium was Important Antecedent

1993 Meeting - Liver classification, chronic rejection, first presentation on molecular pathology approaches, CAP Future of Pathology Consortium consensus discussions 1988-94 were an important antecedent to Banff consensus discussions .

1995 Banff meeting at Banff Centre for Conferences Group Picture of Liver Attendees

1995 Shot - Bruce McManus in Center, Pekka HayryBehind, Fred Sanfillipo in Doorway - Who Else Can You Identify?

More 1995 Shots Kim Solez and Lorraine Racusen

1995 Meeting - Pancreas classification, glomerulitis, first international medical meeting on CD-ROM, first Banff conference with microscope sessions. Lesion scoring normalized with CADI.

1997 Meeting – Banff Springs Hotel

1997 Meeting - Merging of Banff and CCTT classifications, establishing basis for current Banff classification, post-transplant lymphoproliferative disorder, first Banff conference with posters.

1999 Meeting - Larry Hunsicker, Agnes Fogo, and Elaine Solez

1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines. First conference supported by an NIH grant.

1999 Meeting – Michael Kashgarian and Agnes Fogo

1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines. First conference supported by an NIH grant.

1999 Meeting – Glomerulitis Study Group with Kiril Trpkov

1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines. First conference supported by an NIH grant. Glomerulitis study group.

1999 Meeting – Agnes Fogo

1999 Meeting – Larry Hunsicker, Elaine Solez, and Agnes Fogo

2001 Meeting – Larry Hunsicker, Agnes Fogo, Kim Solez and Bob Colvin

2001 Meeting - AMR, donor biopsies, genomics, CAN, heart transplantation

2001 Meeting – Parmjeet Randhawa and Volker Nickeleit

2001 Meeting – Peter Furness

2001 Meeting – Lorraine Racusen

2001 Meeting –David Rush and Denis Glotz

2003 Meeting –J. Stewart Cameron and Andrew Rees

2003 Meeting - C4d, macrophages, tolerance, accommodation, immunodepletion

2003 Meeting –Andrew Rees

2003 Meeting –Doug Wilson

2003 Meeting –Sony Aibo Robotic Dog

2003 Meeting –Michele Hales and Janice McDonald

2003 Meeting –Lorraine Racusen and Family

2005 Meeting – Phil Halloran, Ginny Halloran,Vido Ramassar

2005 Meeting - Genomics and molecular markers, B cells, chronic allograft injury with elimination of CAN, establishment of criteria for chronic rejection.

2005 – Janice McDonald, Charlene Hunter, Banu Sis, Michele Hales

2005 – Kim Solez and Banu Sis

2007 Meeting – Michele Hales and Eduardo Martul

2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas

2007 Meeting – Kunio Morozumi and Michael Mihatsch

2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.

2007 Meeting – Banu Sis

2007 Meeting – Ian Gibson

2007 Meeting – Roz Mannon

2007 Meeting – Michael Mengel

2007 Meeting – Eduardo and Lorraine

2007 Meeting – Nikki Olson and Kim Solez

2007 Meeting – Tori Sheldon, Nikki Olson and Paula Blanco

2007 Meeting – Michael Mengel

2007 Meeting – Tori Sheldon and Nikki Olson

2007 Meeting –Nikki Olson

2007 Meeting –Eduardo and Lorraine and Richard Racusen

2007 Meeting – Dinner in Castle, Nikki Olson, Tori Sheldon, and Bob Colvin

2009 Meeting – Jubilant Tori and AkshathaReturn to Edmonton!

2009 Meeting - Viruses, quality assurance, AMR in kidney, heart, and pancreas, liver allograft accommodation, endothelial cells, surrogate markers. Working groups.

2009 Meeting – Lorraine Racusen and Michael Mengel

2009 Meeting – Mark Haas

2009 Meeting – Jubilant Dar, Akshatha and Tori Head Back to Edmonton!

2011 Meeting – Banu Sis Isolated V

2011 Sensitized patient, C4d, isolated v-lesion, the future, genomics, glomerulitis, epithelial injury/epithelial mesenchymal transformation, operational tolerance monitoring in liver grafts.

2013, 2015, and 2017 – Recent so you have your own favorite images!

Kim Solez’s favorite image from Banff 2017 capturing the spirit of Banff!

Banff 2019 and 2021 will be in Pittsburgh, USA and Banff, Canada. Banff 2019 will have a regenerative medicine/tissue engineering themed pre-meeting.

New Kinnear Conference Center holding 470 people at the Banff Centre for Conferences!

From Kinnear Centre Where We Will Be in 2021 Can See TransCanada Pipeline Pavilion out the Window!

Can see our original site for Banff 1991, 1993, and 1995 out the window!!

Kim Solez 204 years of banff spirit November 10 2017

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