FIGURE 1

FIGURE 2

PATTERNS IN HISTOPATHOLOGY

PRESENTER- DR. ANKITA BAGHELMODERATOR- DR. HEMALATHA A.

OBJECTIVES

• By the end of this session you should be able to differentiate between most of the patterns in histopathology.

HOPEFULLY!!!!

WHAT IS TRABECULAE?

• A small supporting beam or bar.

• Any of the supporting strands of connective tissue projecting into an organ and constituting part of the framework of that organ.

• Any of the fine spicules forming a network in cancellous bone.

TRABECULAR PATTERN

• In cord-like arrays separated by fibrous septa in Long nests and cords of cell groups

• Two cell-thick (microtrabecular pattern)

• Eight to Ten cell-thick (macrotrabecular pattern)

• Cells arranged perpendicular to the longest axis.

EXAMPLES?

HCC HTA

WHAT IS A SYNCYTIUM?

• a multinucleate mass of cytoplasm resulting from fusion of cells.

SYNCYTIAL PATTERN

• Having cytoplasmic continuity between the constituent cells.

• Looks like a collection of nuclei without recognizable borders.

EXAMPLES?

MTC MENINGIOMA

WHAT IS ALVEOLUS?

• a small cavity or pit• a socket in the jaw for a tooth• a small air-containing compartment of the lungs in

which the bronchioles terminate and from which respiratory gases are exchanged with the pulmonary capillaries

• an acinus of a compound gland• a cell of a honeycomb

ALVEOLAR PATTERN• Tumor cells grow in nests or clusters separated by fibrous

septa

• In little sacs or nests or nested structure

ASPS A-RMS

WHAT IS HERRING?

• name given to a type of fish found in the shallow waters of north pacific and north atlantic.

HERRING BONE

• The Herring Bone is nothing but the name given to the skeleton of the Herring fish

HERRING BONE PATTERN

• arrangement in columns of short parallel lines with all the lines in one column sloping one way and lines in adjacent columns sloping the other way.

HERRINGBONE PATTERN

• Shows bundles intersecting in a zig-zag array

FIBROSARCOMA FIBROMA

WHAT IS STORIFORM?

• having an irregularly whorled pattern somewhat like that of a straw mat.

• Having a cartwheel pattern, such as spindle cells having elongated nuclei radiating from a center.

STORIFORM PATTERN

• Cartwheel pattern - spindle cells with elongated nuclei radiating from a center point

• Cellular spindled lesion with whorls as opposed to parallel fasicles or right angle bundles

MFH

WHAT IS A FASCICLE?

• a section of a book or set of books being published in installments as separate pamphlets or volumes.

• a small bundle, tight cluster, or the like.

• a close cluster, as of flowers or leaves.

• a small bundle of nerve or muscle fibers.

FASICULAR• Bundles of elongated spindly cells streaming in polarized

arrays

LEIOMYOMA

GLANDULAR PATTERN• Forming gland structures with lumens having polarized

cells radiating around a lumen

WHAT IS CRIBRIFORM?

• Sieve-like; containing many perforations.• describing a structure with many perforations or

punctures, as in the cribriform plate of the ethmoid bone.

• descriptive term referring to a sieve-like histologic pattern, in which sheets of epithelial cells are punctuated by gland-like spaces

CRIBRIFORM PATTERN• Perforated• Appearance: Well-formed holes within a glandular lumen

ADENOID CYSTIC BREAST DCIS

WHAT IS TUBULE?

• a minute tube, especially as an anatomical structure.

TUBULAR PATTERN

• Crowded small round tubules lined by single to multiple layers of cuboidal to low columnar cells

TUBULAR CA TUBULAR ADENOMA

WHAT IS PAPPILAE?

• any small, nipplelike process or projection.• one of certain small protuberances concerned with

the senses of touch,taste, and smell: the papillae of the tongue.

• a small vascular process at the root of a hair.• a papule or pimple.

PAPILLARY PATTERN

• complex, branching, and randomly oriented, with a central fibrovascular core and a single or stratified lining

PTC INSITU PAPILLARY CA

MICROPAPILLARY

• Papillary-shaped epithelial projections without true fibrovascular cores

• medusa-head appearance

SEROUS CARCINOMA BREAST

WHAT IS INDIAN FILE?

• a line of persons or things arranged one behind the other.

• in a line: to walk single file

INDIAN FILE PATTERN

• Cells in a single line one after the other

LOBULAR CA-INDIAN FILE

HOBNAIL PATTERN

• Resembling a large headed nail used for shoes

• Epithelial or endothelial cells round up and protrude into the lumen as little bumps.

ANGIOSARCOMA

WHAT IS ROSSETTE?• an ornament usually made of material gathered or pleated so as to

resemble a rose and worn as a badge of office, as evidence of having won a decoration (as the Medal of Honor), or as trimming

• a disk of foliage or a floral design usually in relief used as a decorative motif

• a cluster of leaves in crowded circles or spirals arising basally from a crown (as in the dandelion) or apically from an axis with greatly shortened internodes (as in many tropical palms)

• rose windows found in gothic cathedrals

ROSSETTE IN PATHOLOGY

• A rosette is halo or "spoke-wheel" arrangement of cells around a central structure (which can be a lumen or cytoplasmic processes).

CARCINOID

YOLK SAC TUMOUR

MICROCYSTIC PATTERN

• consisting of a loose network of cystic spaces lined by flattened epithelial cells Resembling a network or net-like array

• Microcystic or honeycomb appearance

LYMPH NODE

WHAT IS A FOLLICLE?• A small bodily cavity or sac.• A crypt or minute cul-de-

sac or lacuna, such as the depression in the skin from which the hair emerges.

• An ovarian follicle.• A spherical mass of cells usually containing a cavity.• Botany A dry, single chambered fruit that splits along only one seam to release its seeds, as inlarkspur and milkweed.

FOLLICULAR NEOPLASM THYROID

STAGHORN PATTERN

HEMAGIOPERICYTOMA

Sheets of cellStarry sky

BURKKITS LYMPHOMA

REFERENCES

• Rosai and Ackerman surgical pathology 10th edition• www.pathologyoutlines.com• www.pathpedia.com

THANK YOU